CN107735073A - Cosmetic cosmetic composition comprising layer structure - Google Patents
Cosmetic cosmetic composition comprising layer structure Download PDFInfo
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- CN107735073A CN107735073A CN201680038423.XA CN201680038423A CN107735073A CN 107735073 A CN107735073 A CN 107735073A CN 201680038423 A CN201680038423 A CN 201680038423A CN 107735073 A CN107735073 A CN 107735073A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
This specification is related to the cosmetic cosmetic composition of the oil-in-water form comprising aqueous phase and oil phase, the oil-in-water type cosmetic cosmetic composition includes the inorganic powder for being dispersed in the aqueous phase and being surface-treated with hydrophily coating agent, and also includes the multilayer laminar structure containing ceramide.Excellent preparation stability is had according to the cosmetic cosmetic composition of one aspect of the invention, and admirably makes its moisturizing after application to skin.
Description
Technical field
Present disclosure is related to cosmetic cosmetic composition, and wherein ceramide is by using with hydrophily coating agent table
The inorganic powder of face processing is stablized.
Background technology
Ceramide accounts at least 40% of lipid between the keratinocyte to form cuticula, be to be formed cutin Rotating fields or
Show the required composition of cutin layer function, and the effect strengthened with excellent moistening effect and barrier function.However, as god
When being incorporated into large quantities in cosmetic formulations through acid amides, it is microsolubility, and is therefore made after its particle size reduces
With.But in this case, preparation can undergo stability decline and gelation.
When ceramide with packing forms use to solve problems when, a large amount of encapsulants be present causes ceramide
The shortcomings that actually available content reduces and the encapsulant based on sugar or polymer is using feeling to be deteriorated.
Therefore, by by multilayer laminar liquid crystal increase particle size with the surface of stability can come prevent ceramide because
Gelation caused by grain coalescence.Now, when introducing the powder effective for cosmetic into gained particle, the particle becomes the not phase
Hope unstable.
Present disclosure, which is related to, provides cosmetic cosmetic composition, and it is by using the powder handled with silica surface
End is to remain liquid crystal while stabilization.
[bibliography]
(patent document 1) KR10-2011-0093634A
The content of the invention
Technical problem
The present disclosure technical problem to be solved is to provide oil-in-water type cosmetic cosmetic composition, and it is included
Stable layered liquid crystal prevents ceramide gelation simultaneously.
Present disclosure another to be solved technical problem is to provide the oil-in-water type cosmetic comprising aqueous phase and oil phase
Composition, the composition include the inorganic powder being surface-treated with hydrophily coating agent, and with containing the more of ceramide
Laminate.
Present disclosure another to be solved technical problem, which is to provide to make up for preparing oil-in-water type, to apply some make up group
The method of compound, the composition includes the inorganic powder being surface-treated with hydrophily coating agent, and has multilayer nerve acyl
Amine layer structure.
Technical scheme
In in terms of the generality, there is provided the oil-in-water type cosmetic cosmetic composition comprising aqueous phase and oil phase,
The composition includes the inorganic powder for being surface-treated and being dispersed in the aqueous phase with hydrophily coating agent, and with containing god
Multilayer laminar structure through acid amides.
According to an embodiment, hydrophily coating agent includes at least one selected from silica and cellulose.
According to another embodiment, multilayer laminar structure includes glucoside surfactant.Especially, glucoside surface
Activating agent can be at least one selected from behenyl alcohol, arachidic alcohol, arachidic alcohol glucoside, C14-22 alcohol and C12-20 alkyl glucosides
Kind.
According to another embodiment, ceramide can be at least one selected from natural ceramide and pseudoceramide
Kind.
According to another embodiment, natural ceramide can be selected from Cer EOS, Cer NS, ceramide
3rd, at least one of ceramide 4, ceramide 5, Cer AP, ceramide 7 and ceramide 8.
According to another embodiment, pseudoceramide can be selected from compound shown in formula 1 below to 6 at least
It is a kind of：
[chemical formula 1]
(wherein R is C9-C21 saturations or undersaturated aliphatic chain)
[chemical formula 2]
(wherein n is 1 or 2；And R and R ' are respectively C9-C21 saturations or undersaturated aliphatic chain)
[chemical formula 3]
[wherein m and n it is identical or different and each represent 1 to 3 integer；
K and l it is identical or different and each represent 1 or 2；
J is 0 or 1；
R and R ' is identical or different and each represents the saturation or not with or without the C1-C31 straight or brancheds of hydroxyl
The alkyl of saturation；
A1、A2And A3It is identical or different and each represent the following structures of H or any shown in substituent, on condition that A1、A2
And A3H can not be represented simultaneously：
(wherein M, M1And M2It each is selected from alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium- 4, polyquaternium -6, polyquaternium -7, Polyquaternium-10, polyquaternium -11, polyquaternium -16,
Lauryl dimethyl benzyl ammonium chloride and stearalkonium chloride, and L is alkaline-earth metal)]
[chemical formula 4]
[wherein R and R ' it is identical or different and each represent with or without hydroxyl C10-C32 straight or brancheds it is full
And/or unsaturated alkyl；
R3And R4It is identical or different and each represent H or C1-C4 alkyl or hydroxy alkyl；And
R5For-A or-CH2CH2OA, wherein A are substituent shown in any following structure：
(wherein M, M1And M2Each be selected from alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-
4th, polyquaternium -6, polyquaternium -7, Polyquaternium-10, polyquaternium -11, polyquaternium -16, lauryl dimethyl benzyl
Ammonium chloride and stearalkonium chloride, and L is alkaline-earth metal)]
[chemical formula 5]
[wherein m and n it is identical or different and it is respective represent 1 to 4 integer；R and R ' it is identical or different and it is respective expression contain
Or the not saturation or unsaturated alkyl of the C1-C31 straight or brancheds of hydroxyl；And A1And A2It is identical or different and each represent H
Or substituent shown in any following structure：
(wherein M, M1And M2Selected from alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium -4, poly-
Quaternary ammonium salt -6, polyquaternium -7, Polyquaternium-10, polyquaternium -11, polyquaternium -16, lauryl dimethyl benzyl chlorination
Ammonium and stearalkonium chloride, and L is alkaline-earth metal)]
[chemical formula 6]
[wherein m and n it is identical or different and each represent 1 to 3 integer；
K and l it is identical or different and each represent 1 or 2；
J is 0 or 1；
A1、A2And A3It is identical or different and each represent the following structures of H or any shown in substituent：
(wherein M, M1And M2Respectively alkali metal or nitrogenous organic base, and L is alkaline-earth metal)；
R is the substituent with following structure：
(wherein B is the methyl of 5-, 7- or 8- position of tocopherol, and m is 1 to 3 integer, and D is-CH2(CH3)-CH- or-CH
(CH3)=C-)].
According to another embodiment, the inorganic powder being surface-treated with hydrophily coating agent, which includes, to be selected from hydrophily bag
By at least one of the titanium dioxide of agent surface treatment and the ferriferous oxide being surface-treated with hydrophily coating agent.
According to another embodiment, the inorganic powder being surface-treated with hydrophily coating agent is with total based on the composition
The 0.01 of weight to 25wt% amount uses.
According to another embodiment, ceramide is made with the amount of 0.01 based on the composition total weight to 20wt%
With.
According to another embodiment, the size of layer structure is 2 μm to 30 μm.
In in terms of another generality, there is provided the method for preparing oil-in-water type cosmetic cosmetic composition,
It comprises the following steps：Prepare the oil phase comprising ceramide and glucoside surfactant；By aqueous phase with being coated with hydrophily
The inorganic powder of agent surface treatment is mixed so that the powder disperses；Prepared oil phase is mixed to form mixing with the aqueous phase
Thing；And the mixture is set to be stood at 45 DEG C to 60 DEG C.
In in terms of another generality, there is provided the method for preparing oil-in-water type cosmetic cosmetic composition,
It comprises the following steps：Prepare the oil phase comprising ceramide and glucoside surfactant；Prepare aqueous phase；By prepared oil
Mutually mixed with the aqueous phase to form mixture；The mixture is set to be stood at 45 DEG C to 60 DEG C；And by the mixture
Mixed with the inorganic powder being surface-treated with hydrophily coating agent so that the powder disperses.
Beneficial effect
Excellent preparation stability is had according to the cosmetic cosmetic composition of the one side of present disclosure.
Inorganic powder is included according to the cosmetic cosmetic composition of the one side of present disclosure and simultaneously comprising steady
Fixed ceramide layered liquid crystal.
Shown according to the cosmetic cosmetic composition of the one side of present disclosure after application to skin excellent
Moistening effect.
Recovery is shown after application to skin according to the cosmetic cosmetic composition of the one side of present disclosure
The effect of barrier function.
Improvement is shown after application to skin according to the cosmetic cosmetic composition of the one side of present disclosure
The excellent effect of dry skin.
Best mode
Exemplary will be described more fully below now so that present disclosure will be to art technology
Personnel fully pass on scope of the present disclosure.
According on one side, there is provided the oil-in-water type cosmetic cosmetic composition comprising aqueous phase and oil phase, described group
Compound includes the inorganic powder for being surface-treated and being dispersed in the aqueous phase with hydrophily coating agent, and has and contain ceramide
Multilayer laminar structure.
According to an embodiment, in order to provide the cosmetic with excellent moistening effect and barrier function recovery effects
Cosmetic compositions, ceramide layer structure includes glucoside surfactant, and hydrophily coating agent includes silica
With at least one of cellulose.
According to another embodiment, silica and cellulose can be those obtained by conventional method.However,
It will be apparent to those skilled in the art that silica is not limited to particular category, as long as it is scope of the present disclosure interior
.
According to another embodiment, there is provided oil-in-water type cosmetic cosmetic composition, wherein being coated with hydrophily
It is 2 to the 15wt% coating agent based on inorganic powder weight that the inorganic powder of agent surface treatment, which can include amount,.
Especially, the inorganic powder being surface-treated with hydrophily coating agent can include the coating agent of following amount：At least
2wt%, at least 3wt%, at least 4wt%, at least 5wt%, at least 6wt%, at least 7wt%, at least 8wt%, at least 9wt% or
At least 10wt%.
In addition, the inorganic powder being surface-treated with hydrophily coating agent can include the coating agent of following amount：At most 12wt%,
At most 11wt%, at most 10wt%, at most 9wt%, at most 8wt%, at most 7wt%, at most 6wt%, at most 5wt%, at most
4wt% or at most 3wt%.
When using the coating agent in above range, cosmetic cosmetic composition can include inorganic powder simultaneously comprising steady
Fixed ceramide layered liquid crystal.
According to another embodiment, when coating agent is silicon dioxide coated, titanium dioxide and Huang in inorganic powder
Color ferriferous oxide can be coated with 8 to 12wt% ratio, and red or black ferriferous oxide can be with 10 to 15wt%'s
Ratio is coated with.According to another embodiment, when coating agent is that cellulose is coated with, titanium dioxide, quantity of yellow iron oxide, red
Or black ferriferous oxide can be coated with 2 to 8wt% ratio.
According to another embodiment, there is provided oil-in-water type cosmetic cosmetic composition, wherein multilayer laminar structure
Glucoside surfactant can be included.Especially, glucoside surfactant can be selected from behenyl alcohol, arachidic alcohol, arachidic alcohol
At least one of glucoside, C14-C22 alcohol and C12-C20 alkyl glucosides.
As used in this article, multilayer ceramide layer structure can also include wax or oil.The wax can be selected from alcohol,
Aliphatic acid, vegetable wax, synthetic wax, ceresine, cetin, beeswax, at least one of lipid and lipid peptide.The oil can be with
It is ester oil, hydrocarbon ils or silicone oil.
According to another embodiment, ceramide can be at least one of natural ceramide and pseudoceramide.
Ceramide used herein can be at least one of natural ceramide and pseudoceramide.Natural nerve
Acid amides is for naturally occurring ceramide and including Cer EOS, Cer NS, Cer NP, ceramide 4, nerve
Acid amides 5, Cer AP, ceramide 7, ceramide 8 etc..Pseudoceramide includes Cer EOS 04 and Cer EOS 02.
Pseudoceramide used herein generally covers the compound of the double-strand layer structure with natural ceramide structure.
According to present disclosure, layer structure prevents gelation of the pseudoceramide in its outer layer.When being formed to have
During the thick emulsion that the more stratified layers for having two or more such layer structures surround, it can help to the stabilization of ceramide
Change and excellent gripping and salubrious use feeling are provided.
It is known when curvature reduces and radius of curvature increases, most of rod type SAA comprising ceramide are more stable.Cause
This, the thick emulsion with smaller curvature is more more stable than the low particle emulsion with greater curvature.
According to another embodiment, there is provided oil-in-water type cosmetic cosmetic composition, wherein pseudoceramide are
At least one of compound shown in formula 1 below to 6.
[chemical formula 1]
(wherein R is C9-C21 saturations or undersaturated aliphatic chain)
[chemical formula 2]
(wherein n is 1 or 2；And R and R ' are respectively C9-C21 saturations or undersaturated aliphatic chain)
[chemical formula 3]
[wherein m and n it is identical or different and each represent 1 to 3 integer；
K and l it is identical or different and each represent 1 or 2；
J is 0 or 1；
R and R ' is identical or different and each represents the saturation or not with or without the C1-C31 straight or brancheds of hydroxyl
The alkyl of saturation；
A1、A2And A3It is identical or different and each represent the following structures of H or any shown in substituent, on condition that A1、A2
And A3H can not be represented simultaneously：
(wherein M, M1And M2Each be selected from alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-
4th, polyquaternium -6, polyquaternium -7, Polyquaternium-10, polyquaternium -11, polyquaternium -16, lauryl dimethyl benzyl
Ammonium chloride and stearalkonium chloride, and L is alkaline-earth metal)]
[chemical formula 4]
[wherein R and R ' it is identical or different and each represent with or without hydroxyl C10-C32 straight or brancheds it is full
And/or undersaturated alkyl；
R3And R4It is identical or different and each represent H or C1-C4 alkyl or hydroxy alkyl；And
R5For-A or-CH2CH2OA, wherein A are substituent shown in any following structure：
(wherein M, M1And M2Each be selected from alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-
4th, polyquaternium -6, polyquaternium -7, Polyquaternium-10, polyquaternium -11, polyquaternium -16, lauryl dimethyl benzyl
Ammonium chloride and stearalkonium chloride, and L is alkaline-earth metal)]
[chemical formula 5]
[wherein m and n it is identical or different and it is respective represent 1 to 4 integer；R and R ' it is identical or different and it is respective expression contain
Or the not saturation or unsaturated alkyl of the C1-C31 straight or brancheds of hydroxyl；And A1And A2It is identical or different and each represent H
Or substituent shown in any following structure：
(wherein M, M1And M2Selected from alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium -4, poly-
Quaternary ammonium salt -6, polyquaternium -7, Polyquaternium-10, polyquaternium -11, polyquaternium -16, lauryl dimethyl benzyl chlorination
Ammonium and stearalkonium chloride, and L is alkaline-earth metal)]
[chemical formula 6]
[wherein m and n it is identical or different and each represent 1 to 3 integer；
K and l it is identical or different and each represent 1 or 2；
J is 0 or 1；
A1、A2And A3It is identical or different and each represent the following structures of H or any shown in substituent：
(wherein M, M1And M2Respectively alkali metal or nitrogenous organic base, and L is alkaline-earth metal)；
R is the substituent with following structure：
(wherein B is the methyl of 5-, 7- or 8- position of tocopherol, and m is 1 to 3 integer, and D is-CH2(CH3)-CH- or-CH
(CH3)=C-)].
Compound shown in chemical formula 1 to 6 is that have the false manifestation of vitality of excellent skin moisture-keeping and skin barrier function recovery effects
Through acid amides.
As it is used herein, multilayer ceramide layer structure (that is, multilayer laminar liquid crystal) refers to thick emulsion.It is preferred that
Ground, the average particle size particle size of multilayer ceramide layer structure (i.e. more layered liquid crystals) can be 2 μm to 30 μm.Especially, it is more
The average particle size particle size of layered liquid crystal can be at least 2 μm, at least 3 μm, at least 4 μm, at least 5 μm, at least 6 μm, at least 7 μm,
At least 8 μm, at least 9 μm, at least 10 μm, at least 11 μm, at least 12 μm, at least 13 μm, at least 14 μm, at least 15 μm, at least 16 μ
M, at least 17 μm or at least 18 μm.
In addition, the average particle size particle size of multilayer ceramide layer structure can be at most 30 μm, at most 29 μm, at most 28
μm, at most 27 μm, at most 26 μm, at most 25 μm, at most 24 μm, at most 23 μm, at most 22 μm, at most 21 μm, at most 20 μm, extremely
More 19 μm, at most 18 μm, at most 17 μm, at most 16 μm or at most 15 μm.
When the average particle size particle size of multilayer ceramide layer structure is at least 2 μm, its can stablize pseudoceramide with
Realize the specified point of the use feeling of water profit and improved moistening effect is provided.In addition, when average particle size particle size is more than 30 μm,
Stability reduces.It is therefore preferable that keep above range.
According to another embodiment, there is provided cosmetic cosmetic composition, wherein with hydrophily coating agent surface
The inorganic powder of reason, which includes, to be selected from the titanium dioxide being surface-treated with hydrophily coating agent and is surface-treated with hydrophily coating agent
Ferriferous oxide at least one.
According to another embodiment, there is provided cosmetic cosmetic composition, wherein with hydrophily coating agent surface
The inorganic powder of reason is used with the amount of 0.01 based on the composition total weight to 25wt%.
Especially, with hydrophily coating agent be surface-treated inorganic powder can with based on the composition total weight with
Lower amount uses：At least 0.01wt%, at least 0.5wt%, at least 1wt%, at least 2wt%, at least 3wt%, at least 4wt%, extremely
Few 5wt%, at least 6wt%, at least 7wt%, at least 8wt%, at least 9wt%, at least 10wt%, at least 11wt%, at least
12wt%, at least 13wt%, at least 14wt%, at least 15wt%, at least 16wt%, at least 17wt%, at least 18wt%, at least
19wt%, at least 20wt% or at least 21wt%.
In addition, the inorganic powder being surface-treated with hydrophily coating agent can be used with following amount：At most 25wt%, at most
24wt%, at most 23wt%, at most 22wt%, at most 21wt%, at most 20wt%, at most 19wt%, at most 18wt%, at most
17wt%, at most 16wt%, at most 14wt%, at most 13wt%, at most 12wt% or at most 11wt%.
When the inorganic powder being surface-treated with hydrophily coating agent amount within the above range when, it is possible to provide excellent covering
Effect is so that titanium dioxide in the limitation of its preparation, and shows less dark also less bright color.
According to another embodiment, the inorganic pigment handled with silica or cellulose surface can be by not special
The method known to those skilled in the art of limitation obtains.As a rule, inorganic pigment is disperseed, and addition thereto can be formed
The precursor (for example, tetraethoxysilane) of silica, and then by being heat-treated 1 to 6 hour at a temperature of 50 to 400 DEG C
It is hydrolyzed so that inorganic pigment can be surface-treated with silica.The particular example of inorganic pigment may include titanium dioxide
And yellow, red and black ferriferous oxide, but not limited to this.
According to another embodiment, the titanium dioxide and Huang of usable silica or cellulose surface processing
Color, red and black ferriferous oxide.In the case of the titanium dioxide handled with silica or cellulose surface, its preferred tool
Have 400 to 600nm particle size to provide coverage effect, and its preferably with 0.5 based on the composition total weight to
25wt% amount uses.When the amount is less than 0.5wt%, it is impossible to which the coverage effect of abundance is provided.When the amount is more than
During 25wt%, it is limited beyond the preparation of titanium dioxide.
In addition, what the yellow, red and the black ferriferous oxide that are handled with silica or cellulose surface were determined with color
Amount is used, and they are preferably used with the combined amount of 0.01 based on the composition total weight to 10wt%.When the amount
During less than 0.01wt%, it is impossible to realize desired color.When the amount is more than 10wt%, the composition has too deep
Therefore color is not simultaneously suitable for cosmetic composition.
According to another embodiment, there is provided cosmetic composition, wherein ceramide are with total based on the composition
The 0.01 of weight to 20wt% amount uses.
Especially, ceramide can be used with the following amount based on the composition total weight：At least 0.01wt%, extremely
Few 0.5wt%, at least 1wt%, at least 2wt%, at least 3wt%, at least 4wt%, at least 5wt%, at least 6wt%, at least
7wt%, at least 8wt%, at least 9wt%, at least 10wt%, at least 11wt%, at least 12wt%, at least 13wt%, at least
14wt%, at least 15wt%, at least 16wt% or at least 17wt%.
In addition, ceramide can be used with the following amount based on the composition total weight：At most 20wt%, at most
19wt%, at most 18wt%, at most 17wt%, at most 16wt%, at most 15wt%, at most 14wt%, at most 13wt%, at most
12wt% or at most 11wt%.
When ceramide is within the above range in use, after application to skin, it can provide excellent skin moisture-keeping effect
Fruit and improve dry skin.
In another aspect, there is provided the method for preparing oil-in-water type cosmetic cosmetic composition, it includes
Following steps：Prepare the oil phase comprising ceramide and glucoside surfactant；By aqueous phase with using hydrophily coating agent surface
The inorganic powder of processing is mixed so that the powder disperses；Prepared oil phase is mixed to form mixture with the aqueous phase；With
And the mixture is set to be stood at 45 DEG C to 60 DEG C.
In another aspect, there is provided the method for preparing oil-in-water type cosmetic cosmetic composition, it includes
Following steps：Prepare the oil phase comprising ceramide and glucoside surfactant；Prepare aqueous phase；By prepared oil phase and institute
Aqueous phase mixing is stated to form mixture；The mixture is set to be stood at 45 DEG C to 60 DEG C；And by the mixture with using parent
The inorganic powder of aqueous wrapped dose of surface treatment is mixed so that the powder disperses.
According to an embodiment, the step of standing the mixture, plays a significant role in layer structure is formed.
Especially, the step of standing the mixture, can be carried out under temperature below：At least 45 DEG C, at least 46 DEG C, extremely
It is few 47 DEG C, at least 48 DEG C, at least 49 DEG C, at least 50 DEG C, at least 51 DEG C, at least 52 DEG C, at least 53 DEG C or at least 54 DEG C.
In addition, the step of standing the mixture, can be carried out under temperature below：At most 60 DEG C, at most 59 DEG C, at most
58 DEG C, at most 57 DEG C, at most 56 DEG C, at most 55 DEG C, at most 54 DEG C, at most 53 DEG C, at most 52 DEG C, at most 51 DEG C or at most 50
℃。
When temperature within the above range when, be stably formed layer structure.
According to another embodiment, the step of standing the mixture may proceed to it is few 20 minutes, at least 25 minutes,
At least 30 minutes, at least 35 minutes, at least 40 minutes, at least 50 minutes, at least 60 minutes, at least 70 minutes, at least 80 minutes
Or at least 100 minutes.
When the time within the above range when, be stably formed layer structure.
According to another embodiment, hydrophily coating agent includes at least one selected from silica and cellulose.
According to another embodiment, glucoside surfactant is selected from following at least one：Behenyl alcohol, peanut
Alcohol, arachidic alcohol glucoside, C14-22 alcohol and C12-20 alkyl glucosides.
The oil-in-water type cosmetic base containing colouring agent can be configured to according to the cosmetic cosmetic composition of present disclosure
Matter or foundation cream, but not limited to this.
Embodiment
Hereinafter, present disclosure will be explained with reference to embodiment and comparative example.However, following examples are only used for
Illustrate purpose, it is no intended to limit the scope of the disclosure.The person skilled in the art will easily understand do not carrying on the back
Following examples and test case can be done under conditions of the spirit and scope of the present disclosure limited from appended claims
Go out modification, replace and insert.
Examples 1 and 2 and comparative example 1 and 2
Group of the oil-in-water type cosmetic cosmetic composition of Examples 1 and 2 and comparative example 1 and 2 according to table 1 below
Into preparation.(obtained with alkyl silane (obtained from Daito Kasei OTS series, in all cases with 2% coating)/silica
From JGC Catalysts and Chemicals Ltd. Sympholight series, in titanium dioxide and the feelings of quantity of yellow iron oxide
With 10% coating under condition, with 12% coating in the case of red/black ferriferous oxide)/cellulose (is obtained from Daito Kasei
C2 series, in all cases with 5% coating) surface treatment inorganic powder be commercially available prod.
[table 1]
1) oil-phase solution is prepared according to the composition of table 1 at 75 DEG C.As pseudoceramide, the double palmityls of hydroxypropyl are used
Amine MEA (Pc104) and the double lauramide MEA (Pc102) of hydroxypropyl.
2) in independent container, aqueous phase solution is prepared at 75 DEG C and mixes and is dispersed in aqueous solution with colouring agent
(in the case of the alkyl silane of comparative example 2, being mixed and dispersed in colouring agent in oil-phase solution).
3) oil-phase solution of step 1) is added to the aqueous phase solution of step 2), and stirred by using homomixer
And mix gained mixture.
4) mixture is kept about 35 minutes under about 52 DEG C of chilling temperature, is cooled to 30 DEG C, and it is then completely de-
Gas is to obtain oil-in-water type cosmetic cosmetic composition.
Embodiment 3 and 4 and comparative example 3 to 5
The oil-in-water type cosmetic cosmetic composition of embodiment 3 and 4 and comparative example 3,4 and 5 is according to table 2 below
It is prepared by composition.
[table 2]
1) oil-phase solution is prepared according to the composition of table 2 at 75 DEG C.As pseudoceramide, the double palmityls of hydroxypropyl are used
Amine MEA (Pc104) and the double lauramide MEA (Pc102) of hydroxypropyl.
2) in a separate container, aqueous phase solution is prepared at 75 DEG C.
3) oil-phase solution of step 1) is added to the aqueous phase solution of step 2), and stirred by using homomixer
With mixing gained mixture.
4) mixture is kept about 35 minutes under about 52 DEG C of chilling temperature, and colouring agent is mixed and disperses
In the mixture.
5) mixture is cooled to 3 DEG C, and be then thoroughly degassed to obtain oil-in-water type cosmetic cosmetic composition.
The comparison of [test case 1] stability
In order to determine the preparation stability of the cosmetic cosmetic composition according to present disclosure, embodiment 1 to 4 and ratio
Compared with example 1 to 5 each with 10g measure out and by each sample introduce cryostat (4 DEG C), thermostat (30 DEG C), high temperature
Kept for 24 hours in thermostat (45 DEG C) and -10 DEG C of circular chambers to 45 DEG C of temperature cycles and observe the change of preparation with true
Determine stability.As a result it is shown in table 3 below and table 4.
[table 3]
Result such as table 3 can be seen that comparative example 1 and show bad stability, because the layer structure is not coated with
(not being surface-treated) inorganic powder destroy, cause deemulsification.Be coated with the comparative example 2 of hydrophobic alkyl silane due to
Inversion of phases during preparation causes its preparation can not be formed in itself.It is coated with the embodiment 1 of hydrophilic cellulose and silica
The multilayer laminar liquid crystal that particle size is 2 μm or bigger is formed with 2, but it is somewhat unstable in terms of the long-time stability at 45 DEG C
It is fixed.
[table 4]
Multilayer laminar liquid crystal is prepared using distinct methods, it is by the way that reactant mixture is maintained at about 52 DEG C about 35 minutes
And different types of pigment is dispersed therein.As a result it is shown in Table 4.It can be seen that comparative example 3 shows low yield thing value, because
The multilayer laminar structure being previously formed is destroyed by the inorganic powder of vntreated and particle size excessively reduces, and causes 45
Gelation at DEG C.Comparative example 4 does not have product value, because the inorganic powder for being coated with hydrophobic alkyl silane is forming oil-in-water type
It is introduced into after emulsion and the powder is not uniformly dispersed in emulsion.On the contrary, it is coated with hydrophilic cellulose and titanium dioxide
The embodiment 3 and 4 of silicon keeps the multilayer laminar liquid crystal being previously formed and stablized 6 months at 45 DEG C, and thus it is shown that excellent
Different phase stability.This shows to use the inorganic powder being surface-treated with hydrophilic material in the composition containing pseudoceramide
Provide the excellent effect for preventing pseudoceramide gelation while keeping multilayer laminar liquid crystal.
Comparative example 5 is stable and does not have gelation, because it is free of ceramide.
The evaluation of [test case 2] skin moisture-keeping confining force
In order to determine the skin moisture-keeping confining force after cosmetic cosmetic composition is applied once, make 80 30
Adult male and women up to more than 40 are to applying on its face and inner forearm according to embodiment 3 and 4 and comparative example 5
Each of cosmetic cosmetic composition.Then, using transepidermal water tester (corneometer) (CM820 courage
Khazaka electronic GmbH, Germany) measure skin water content 24 hours.Before each composition is applied, in advance in perseverance
The value for measuring skin water content using transepidermal water tester under gentle constant humidity condition (24 DEG C, humidity 40%) and measuring as
Reference.In addition, after administration immediately, 2 hours after administration, after administration 4 hours and after administration 8 hours survey
Measure the change of skin water content.As a result it is shown in table 5 below.
<Transepidermal water tester measures>
Principle：It is present in the water in epiderm skin and ionic strength in water is measured by using sensor, by ionic strength
Digitlization and calculate the amount of water and determine, so that it is determined that moistening effect.
1) transepidermal water tester probe is placed in the skin site that will be determined.
2) when probe compressing is leaned against on skin, the electric capacity of skin by sensor digital and is shown on screen.
3) after determining once, sensor is wiped with paper handkerchief (such as Kim Wipe), and use it in different positions
Upper replication.
[table 5]
It can be seen from the result of table 5 compared with the comparative example 5 not comprising ceramide, according to the bag of present disclosure
The cosmetic cosmetic composition of embodiment 3 and 4 containing ceramide shows that skin water content is higher immediately after administration
Raising, and such raising skin moisturization keep at least 8 hours.
In addition, after completion of testing, test group is investigated and is using each cosmetic cosmetic combinations to check
Improve the effect of dry skin after thing.The average value (5 points of systems) of evaluation result is shown in table 6 below.
[table 6]
The result of table 6 shows, compared with comparative example 5, cosmetic cosmetic composition (the wherein neural acyl of embodiment 3 and 4
Amine is by using the inorganic powder being surface-treated with hydrophilic material come stable) show the significantly higher of improvement dry skin
Effect.
Claims (14)
1. the oil-in-water type cosmetic cosmetic composition comprising aqueous phase and oil phase, the composition include and use hydrophily coating agent
The inorganic powder for being surface-treated and being dispersed in the aqueous phase, and there is the multilayer laminar structure containing ceramide.
2. oil-in-water type cosmetic cosmetic composition according to claim 1, wherein the hydrophily coating agent includes
At least one selected from silica and cellulose.
3. oil-in-water type cosmetic cosmetic composition according to claim 1, wherein with hydrophily coating agent surface
The inorganic powder of reason includes the coating agent of 2 based on the inorganic powder gross weight to 15wt% ratios.
4. oil-in-water type cosmetic cosmetic composition according to claim 1, wherein the multilayer laminar structure includes
Glucoside surfactant.
5. oil-in-water type cosmetic cosmetic composition according to claim 4, wherein the glucoside surfactant
For at least one selected from behenyl alcohol, arachidic alcohol, arachidic alcohol glucoside, C14-22 alcohol and C12-20 alkyl glucosides.
6. oil-in-water type cosmetic cosmetic composition according to claim 1, wherein the ceramide is selected from day
At least one of right ceramide and pseudoceramide.
7. oil-in-water type cosmetic cosmetic composition according to claim 6, wherein the natural ceramide is choosing
From Cer EOS, Cer NS, Cer NP, ceramide 4, ceramide 5, Cer AP, ceramide 7 and nerve
At least one of acid amides 8.
8. oil-in-water type cosmetic cosmetic composition according to claim 6, wherein the pseudoceramide be selected from
At least one of compound shown in formula 1 below to 6：
[chemical formula 1]
(wherein R is C9-C21 saturations or undersaturated aliphatic chain)
[chemical formula 2]
(wherein n is 1 or 2；And R and R ' are respectively C9-C21 saturations or undersaturated aliphatic chain)
[chemical formula 3]
[wherein m and n it is identical or different and each represent 1 to 3 integer；
K and l it is identical or different and each represent 1 or 2；
J is 0 or 1；
R and R ' is identical or different and each represents the saturation or unsaturation of the C1-C31 straight or brancheds with or without hydroxyl
Alkyl；
A1、A2And A3It is identical or different and each represent the following structures of H or any shown in substituent, on condition that A1、A2And A3
H can not be represented simultaneously：
(wherein M, M1And M2It each is selected from alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium -4, poly-
Quaternary ammonium salt -6, polyquaternium -7, Polyquaternium-10, polyquaternium -11, polyquaternium -16, lauryl dimethyl benzyl chlorination
Ammonium and stearalkonium chloride, and L is alkaline-earth metal)]
[chemical formula 4]
[wherein R and R ' it is identical or different and each represent with or without the C10-C32 straight or brancheds of hydroxyl saturation or
Unsaturated alkyl；
R3And R4It is identical or different and each represent H or C1-C4 alkyl or hydroxy alkyl；And
R5For-A or-CH2CH2OA, wherein A are substituent shown in any following structure：
(wherein M, M1And M2It each is selected from alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium -4, poly-
Quaternary ammonium salt -6, polyquaternium -7, Polyquaternium-10, polyquaternium -11, polyquaternium -16, lauryl dimethyl benzyl chlorination
Ammonium and stearalkonium chloride, and L is alkaline-earth metal)]
[chemical formula 5]
[wherein m and n it is identical or different and it is respective represent 1 to 4 integer；R and R ' is identical or different and respective expression contains or not
The saturation or unsaturated alkyl of the C1-C31 straight or brancheds of hydroxyl；And A1And A2Identical or different and respective expression H appoints
Substituent shown in a kind of following structure：
(wherein M, M1And M2Selected from alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium -4, polyquaternary amine
Salt -6, polyquaternium -7, Polyquaternium-10, polyquaternium -11, polyquaternium -16, lauryl dimethyl benzyl ammonium chloride and
Stearalkonium chloride, and L is alkaline-earth metal)]
[chemical formula 6]
[wherein m and n it is identical or different and each represent 1 to 3 integer；
K and l it is identical or different and each represent 1 or 2；
J is 0 or 1；
A1、A2And A3It is identical or different and each represent the following structures of H or any shown in substituent：
(wherein M, M1And M2Respectively alkali metal or nitrogenous organic base, and L is alkaline-earth metal)；
R is the substituent with following structure：
(wherein B is the methyl of 5-, 7- or 8- position of tocopherol, and m is 1 to 3 integer, and D is-CH2(CH3)-CH- or-CH (CH3)
=C-)].
9. oil-in-water type cosmetic cosmetic composition according to claim 1, wherein with hydrophily coating agent surface
The inorganic powder of reason, which includes, is selected from the titanium dioxide that is surface-treated with hydrophily coating agent and with hydrophily coating agent surface
At least one of the ferriferous oxide of processing.
10. oil-in-water type cosmetic cosmetic composition according to claim 1, wherein with hydrophily coating agent surface
The inorganic powder of reason is used with the amount of 0.01 based on the composition total weight to 25wt%.
11. oil-in-water type cosmetic cosmetic composition according to claim 1, wherein the ceramide is with based on institute
0.01 to the 20wt% amount for stating composition total weight uses.
12. oil-in-water type cosmetic cosmetic composition according to claim 1, wherein the size of layered structure is
2 μm to 30 μm.
13. the method for preparing the oil-in-water type cosmetic cosmetic composition according to any one of claim 1 to 12,
It comprises the following steps：
Prepare the oil phase comprising ceramide and glucoside surfactant；
Aqueous phase is mixed so that the powder disperses with the inorganic powder being surface-treated with hydrophily coating agent；
Prepared oil phase is mixed to form mixture with the aqueous phase；And
The mixture is set to be stood at 45 DEG C to 60 DEG C.
14. the method for preparing the oil-in-water type cosmetic cosmetic composition according to any one of claim 1 to 12,
It comprises the following steps：
Prepare the oil phase comprising ceramide and glucoside surfactant；
Prepare aqueous phase；
Prepared oil phase is mixed to form mixture with the aqueous phase；
The mixture is set to be stood at 45 DEG C to 60 DEG C；And
The mixture is mixed so that the powder disperses with the inorganic powder being surface-treated with hydrophily coating agent.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| KR10-2015-0093317 | 2015-06-30 | ||
| KR1020150093317A KR102418097B1 (en) | 2015-06-30 | 2015-06-30 | Makeup cosmetic composition comprising lamellar structure |
| PCT/KR2016/006681 WO2017003129A1 (en) | 2015-06-30 | 2016-06-23 | Makeup cosmetic composition comprising lamella structure |
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| CN107735073A true CN107735073A (en) | 2018-02-23 |
| CN107735073B CN107735073B (en) | 2021-03-05 |
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| CN201680038423.XA Active CN107735073B (en) | 2015-06-30 | 2016-06-23 | Cosmetic composition for making up comprising a layered structure |
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| Country | Link |
|---|---|
| KR (1) | KR102418097B1 (en) |
| CN (1) | CN107735073B (en) |
| HK (1) | HK1248553A1 (en) |
| TW (1) | TWI701051B (en) |
| WO (1) | WO2017003129A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010083A (en) * | 2018-09-07 | 2018-12-18 | 广州华玺生物科技有限公司 | A kind of carbon dioxide composite facial mask composition of layered structure and preparation method thereof constituted with amphiphilic substance |
| CN112566612A (en) * | 2018-08-10 | 2021-03-26 | 株式会社资生堂 | Multi-layer cosmetic |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102453889B1 (en) * | 2017-09-29 | 2022-10-11 | (주)아모레퍼시픽 | emulsion cosmetic composition |
| KR102576017B1 (en) * | 2021-10-07 | 2023-09-07 | 성균관대학교산학협력단 | Water-dispersible ceramide particles, manufacturing method thereof, and emulsion composition comprising the same |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101014316A (en) * | 2004-09-07 | 2007-08-08 | 株式会社Lg生活健康 | Cosmetic powder, its preparing method and make-up cosmetic composition comprising the same |
| JP2010047293A (en) * | 2008-08-22 | 2010-03-04 | Denso Corp | Box and method of packaging honeycomb structure |
| CN101674798A (en) * | 2007-04-26 | 2010-03-17 | 株式会社资生堂 | Oil-in-water emulsion composition and method for producing the same |
| KR20110076076A (en) * | 2009-12-29 | 2011-07-06 | 웅진코웨이주식회사 | Water-in-silicone type emulsion composition having liquid-crystal in waterphase and use thereof |
| CN103796641A (en) * | 2011-09-16 | 2014-05-14 | 株式会社爱茉莉太平洋 | Composition for skin external use containing ceramide |
| KR20140142412A (en) * | 2013-06-03 | 2014-12-12 | (주)네오팜 | Complex coating powder for cosmetics and the cosmetics containing the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010047493A (en) * | 2008-08-19 | 2010-03-04 | Septem Soken:Kk | Microcapsule and skin external preparation containing the same |
| KR101762246B1 (en) * | 2009-11-26 | 2017-08-01 | (주)아모레퍼시픽 | Oil in water type cosmetic composition containing the inorganic pigments coated silica |
| KR101196115B1 (en) | 2011-01-31 | 2012-10-30 | 주식회사백상 | The Methods and Facilities for the Load Adjustment of the Sling Rods and Pipe Hangers |
| KR20160019855A (en) * | 2014-08-12 | 2016-02-22 | 주식회사 엘지생활건강 | Oil-based makeup cosmetic composition comprising base composition containing polydatin with antioxidant activity |
-
2015
- 2015-06-30 KR KR1020150093317A patent/KR102418097B1/en active IP Right Grant
-
2016
- 2016-06-20 TW TW105119262A patent/TWI701051B/en not_active IP Right Cessation
- 2016-06-23 WO PCT/KR2016/006681 patent/WO2017003129A1/en active Application Filing
- 2016-06-23 CN CN201680038423.XA patent/CN107735073B/en active Active
-
2018
- 2018-06-27 HK HK18108265.1A patent/HK1248553A1/en unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101014316A (en) * | 2004-09-07 | 2007-08-08 | 株式会社Lg生活健康 | Cosmetic powder, its preparing method and make-up cosmetic composition comprising the same |
| CN101674798A (en) * | 2007-04-26 | 2010-03-17 | 株式会社资生堂 | Oil-in-water emulsion composition and method for producing the same |
| JP2010047293A (en) * | 2008-08-22 | 2010-03-04 | Denso Corp | Box and method of packaging honeycomb structure |
| KR20110076076A (en) * | 2009-12-29 | 2011-07-06 | 웅진코웨이주식회사 | Water-in-silicone type emulsion composition having liquid-crystal in waterphase and use thereof |
| CN103796641A (en) * | 2011-09-16 | 2014-05-14 | 株式会社爱茉莉太平洋 | Composition for skin external use containing ceramide |
| KR20140142412A (en) * | 2013-06-03 | 2014-12-12 | (주)네오팜 | Complex coating powder for cosmetics and the cosmetics containing the same |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112566612A (en) * | 2018-08-10 | 2021-03-26 | 株式会社资生堂 | Multi-layer cosmetic |
| CN112566612B (en) * | 2018-08-10 | 2023-09-05 | 株式会社资生堂 | Multi-layer cosmetic |
| CN109010083A (en) * | 2018-09-07 | 2018-12-18 | 广州华玺生物科技有限公司 | A kind of carbon dioxide composite facial mask composition of layered structure and preparation method thereof constituted with amphiphilic substance |
| CN109010083B (en) * | 2018-09-07 | 2021-11-02 | 广州华玺生物科技有限公司 | Carbon dioxide composite facial mask composition with layered structure composed of amphiphilic substances and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20170003097A (en) | 2017-01-09 |
| WO2017003129A1 (en) | 2017-01-05 |
| HK1248553A1 (en) | 2018-10-19 |
| TWI701051B (en) | 2020-08-11 |
| TW201713303A (en) | 2017-04-16 |
| CN107735073B (en) | 2021-03-05 |
| KR102418097B1 (en) | 2022-07-08 |
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