CN107714525A - A kind of whitening spot-removing special efficacy Essence - Google Patents

A kind of whitening spot-removing special efficacy Essence Download PDF

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Publication number
CN107714525A
CN107714525A CN201610675303.2A CN201610675303A CN107714525A CN 107714525 A CN107714525 A CN 107714525A CN 201610675303 A CN201610675303 A CN 201610675303A CN 107714525 A CN107714525 A CN 107714525A
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parts
licorice
essence
whitening
amino acid
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CN201610675303.2A
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Chinese (zh)
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王素萍
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Individual
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Priority to CN201610675303.2A priority Critical patent/CN107714525A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin

Abstract

The invention discloses a kind of whitening spot-removing special efficacy Essence, its formula is made up of according to parts by weight the following raw material:50 60 parts of metallothionein,35 parts of Trenaxmine,13 19 parts of hyaluronic acid,5 10 parts of Hydrolyzed Collagen,Top 11 15 parts of natural whiting moisturizing factor,15 parts of amino acid humectant,8 14 parts of licorice,13 parts of olive oil,36 parts of ursin,15 parts of lecithin wax,58 parts of bigarabe flower essential oil,19 parts of brown alga gel,3 parts of Cer EOS,The cleawhite over-night essences utilizes metallothionein,Trenaxmine and hyaluronic acid,The lead of skin bottom can be excluded,Mercury,Hormone and skin rubbish toxin,The light spot of whitening effect,Anti-inflammatory anti-acne,Replenishing water and preserving moisture,Take off red reparation,The cleawhite over-night essences is using the biological enzymolysis product of licorice as main active component,Collaboration plays a role,Suppress melanin generation and migration reaches the effect of skin whitening,Contain ursin elite,Rich in abundant vitamin A,E and protein and other trace elements.

Description

A kind of whitening spot-removing special efficacy Essence
Technical field
The present invention relates to freckle removing and whitening technical field, and in particular to a kind of whitening spot-removing special efficacy Essence.
Background technology
The melanin that the colour of skin, hair color and the eye color of people mainly synthesizes with melanocyte (melanocyte) (melanin) type, quantity and distribution are relevant.It is first by the catalytic action of tyrosinase, tyrosine in melanocyte After be oxidized to DOPA and DOPA quinone, DOPA quinone further changes into dopachrome;In DHI enzymes and dopachrome interconvertible enzyme Under the difference catalytic action of DHICA oxidizing ferment, dopachrome passes through 5,6- dihydroxy indoles and 5,6- dihydroxy indole -2- carboxylics Acid is further converted to 5,6- istains and 5,6- istain -2- carboxylic acids;5,6- istains and 5,6- istain -2- carboxylic acids are last Polymerization forms melanin.Tyrosinase is the first step rate-limiting enzyme and key enzyme of B16 cell.Therefore, in most of whitening agents All contain tyrosinase inhibitor.
It is many due to forming melanin, makes product whitening effect notable, it is necessary to which Comprehensive considers The reason for melanin formation, it can only in this way design efficient whitening product.But multipath acts on the life of melanin Into and transfer process, it is necessary to consider the security, stability and outward appearance of product.Therefore, select have it is multi-functional, stably, Safety and whitening raw material of light color, play it and cooperate with whitening function, have great importance.
Influenceed because modern people's rhythm of life is fast, and by various environment, skin is often dried, intensely dark damp, appearance Easy long spot.The nti-freckle product on Cosmetic Market is largely containing preservative, bactericide, spices, synthetic dyestuff, ethanol at present Deng, consumer after long-term use of such product, allergic reaction or pigment deposition occurs in skin, makes color spot more long more, more Even Other diseases can be induced for serious.
The content of the invention
For problem above, the invention provides a kind of whitening spot-removing special efficacy Essence, the cleawhite over-night essences utilizes metal Sulfoprotein, Trenaxmine and hyaluronic acid, lead, mercury, hormone and skin rubbish toxin, the whitening effect that can exclude skin bottom are light Spot, anti-inflammatory anti-acne, replenishing water and preserving moisture, red reparation is taken off, be a pure natural skin-protection product of the high-tech imitated entirely, can effectively solve to carry on the back The problem of in scape technology.
To achieve these goals, the technical solution adopted by the present invention is as follows:A kind of whitening spot-removing special efficacy Essence, it is matched somebody with somebody Side is made up of according to parts by weight the following raw material:
Metallothionein 50-60 parts, Trenaxmine 3-5 parts are hyaluronic acid 13-19 parts, Hydrolyzed Collagen 5-10 parts, top Natural whiting moisturizing factor 11-15 parts, amino acid humectant 1-5 parts, licorice 8-14 parts, olive oil 1-3 parts, ursin 3-6 parts, lecithin wax 1-5 parts, bigarabe flower essential oil 5-8 parts, brown alga gel 1-9 parts, -3 parts of Cer EOS.
Preferably, the formula of the Essence is made up of according to parts by weight the following raw material:
50 parts of metallothionein, 3 parts of Trenaxmine, 13 parts of hyaluronic acid, 5 parts of Hydrolyzed Collagen, top natural whiting are protected Wet 11 parts of the factor, 1 part of amino acid humectant, 8 parts of licorice, 1 part of olive oil, 3 parts of ursin, 1 part of lecithin wax, bigarabe flower 5 parts of essential oil, 1 part of brown alga gel, Cer EOS part.
Preferably, the formula of the Essence is made up of according to parts by weight the following raw material:
60 parts of metallothionein, 5 parts of Trenaxmine, 19 parts of hyaluronic acid, 10 parts of Hydrolyzed Collagen, top natural whiting are protected Wet 15 parts of the factor, 5 parts of amino acid humectant, 14 parts of licorice, 3 parts of olive oil, 6 parts of ursin, 5 parts of lecithin wax, bigarabe 8 parts of flower essential oil, 9 parts of brown alga gel, Cer NP part.
The other present invention have also been devised a kind of preparation method of whitening spot-removing special efficacy Essence, comprise the following steps:
(1) according to recipe configuration raw material, top natural whiting moisturizing factor, amino acid humectant and radix glycyrrhizae extraction will be removed Other raw materials of thing are simultaneously added in reaction pot, are heated to 78-82 DEG C while stirring, until being uniformly dispersed;
(2) 48-55 DEG C is cooled to, and adds licorice, continues to obtain preliminary Essence after stirring 30-40 minutes;
(3) room temperature is cooled to, top natural whiting moisturizing factor, amino acid humectant is added, stirs, and low-grade fever 5-7 minutes, normal temperature is subsequently cooled to, obtains Essence.
Beneficial effects of the present invention:
The cleawhite over-night essences utilizes metallothionein, Trenaxmine and hyaluronic acid, can exclude the lead of skin bottom, mercury, Hormone and skin rubbish toxin, the light spot of whitening effect, anti-inflammatory anti-acne, replenishing water and preserving moisture, red reparation is taken off, the cleawhite over-night essences is with radix glycyrrhizae The biological enzymolysis product of extract is main active component, and collaboration plays a role, and suppresses melanin generation and migration reaches beautiful The effect of pale skin, contain ursin elite, rich in abundant vitamin A, E and protein and other trace elements, have Stronger infiltration repair ability, wakes up skin life, and protection rebuilds sebum film, softens thick and heavy cuticula;It can desalinate simultaneously true Pigment color spot in cortex, accelerate melanin to decompose and drain, skin whitening, be a complete so as to reduce Skin pigmentation The pure natural skin-protection product of high-tech of effect.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.
Embodiment 1:
The invention provides a kind of whitening spot-removing special efficacy Essence, its formula is made up of according to parts by weight the following raw material:
50 parts of metallothionein, 3 parts of Trenaxmine, 13 parts of hyaluronic acid, 5 parts of Hydrolyzed Collagen, top natural whiting are protected Wet 11 parts of the factor, 1 part of amino acid humectant, 8 parts of licorice, 1 part of olive oil, 3 parts of ursin, 1 part of lecithin wax, bigarabe flower 5 parts of essential oil, 1 part of brown alga gel, Cer EOS part.
Its preparation method comprises the following steps:
(1) according to recipe configuration raw material, top natural whiting moisturizing factor, amino acid humectant and radix glycyrrhizae extraction will be removed Other raw materials of thing are simultaneously added in reaction pot, are heated to 78 DEG C while stirring, until being uniformly dispersed;
(2) 48 DEG C are cooled to, and adds licorice, preliminary Essence is obtained after continuing stirring 30 minutes;
(3) room temperature is cooled to, top natural whiting moisturizing factor, amino acid humectant is added, stirs, and low-grade fever 5 minutes, normal temperature is subsequently cooled to, obtains Essence.
Embodiment 2:
The invention provides a kind of whitening spot-removing special efficacy Essence, its formula is made up of according to parts by weight the following raw material:
55 parts of metallothionein, 4 parts of Trenaxmine, 16 parts of hyaluronic acid, 8 parts of Hydrolyzed Collagen, top natural whiting are protected Wet 13 parts of the factor, 3 parts of amino acid humectant, 11 parts of licorice, 2 parts of olive oil, 5 parts of ursin, 4 parts of lecithin wax, bigarabe 6 parts of flower essential oil, 5 parts of brown alga gel, Cer NS part.
The preparation method of the special efficacy Essence comprises the following steps:
(1) according to recipe configuration raw material, top natural whiting moisturizing factor, amino acid humectant and radix glycyrrhizae extraction will be removed Other raw materials of thing are simultaneously added in reaction pot, are heated to 80 DEG C while stirring, until being uniformly dispersed;
(2) 50 DEG C are cooled to, and adds licorice, preliminary Essence is obtained after continuing stirring 35 minutes;
(3) room temperature is cooled to, top natural whiting moisturizing factor, amino acid humectant is added, stirs, and low-grade fever 6 minutes, normal temperature is subsequently cooled to, obtains Essence.
Embodiment 3:
The invention provides a kind of whitening spot-removing special efficacy Essence, its formula is made up of according to parts by weight the following raw material:
60 parts of metallothionein, 5 parts of Trenaxmine, 19 parts of hyaluronic acid, 10 parts of Hydrolyzed Collagen, top natural whiting are protected Wet 15 parts of the factor, 5 parts of amino acid humectant, 14 parts of licorice, 3 parts of olive oil, 6 parts of ursin, 5 parts of lecithin wax, bigarabe 8 parts of flower essential oil, 9 parts of brown alga gel, Cer NP part.
The preparation method of the special efficacy Essence comprises the following steps:
(1) according to recipe configuration raw material, top natural whiting moisturizing factor, amino acid humectant and radix glycyrrhizae extraction will be removed Other raw materials of thing are simultaneously added in reaction pot, are heated to 82 DEG C while stirring, until being uniformly dispersed;
(2) 55 DEG C are cooled to, and adds licorice, preliminary Essence is obtained after continuing stirring 40 minutes;
(3) room temperature is cooled to, top natural whiting moisturizing factor, amino acid humectant is added, stirs, and low-grade fever 7 minutes, normal temperature is subsequently cooled to, obtains Essence.
Application method:The immersion of face paper pure water is gone after water to pour into after a whole bottle evil spirit liquid uniformly soaks after face cleaning and spread on Facial 20--30 minutes (evening applying film can be with disposable) are applied once for every four days.
The cleawhite over-night essences provided in this experimental selection embodiment 3 carries out clinical trial.
The experiment includes 23 volunteers, and in 23-50 one full year of life, face had due to Exposure to Sunlight, operating pressure, age female age The spot Deng caused by.Tested material and all information are used according to regulations during experiment.Cleawhite over-night essences is smeared twice sooner or later daily, Test period is 4 weeks.Face image number is obtained by VISIA-CR in W0 (before use), W2 (using 2 weeks), W4 (using 4 weeks) According to, and examine its otherness with the change of SSA software analysis face particular spots L* values, and with t.Its result is as follows:
1.L value changes tables
Note:* represents difference highly significant (P < 0.01)
It can see from table, it can be seen that after two weeks, skin colourity L* values just have increase trend, and obvious big Level before use, difference have statistical significance (p < 0.01), after illustrating that face uses cleawhite over-night essences, skin face Color gradually becomes shallower as and color spot color is gradually thin out.
2. volunteer's self-assessment
Using questionnaire form, the degree changed by the skin color depth before and after subject's self-assessment product use and spot size To judge that product improves degree to skin.Wherein without improvement refer to color spot size it is unchanged/colour of skin is unchanged;Slight improve refers to Color spot slightly reduces, thin out/overall colour of skin has highlighted;Moderate, which improves, refers to that color spot is obviously reduced, and thin out/overall colour of skin is obvious Highlight.Using in sample E surroundings, subject thinks account for total number of persons 38% that blee moderate improves, is slightly improved as 54%;And in terms of color spot improvement, it is believed that moderate improve for 15%, slight improve account for 77%.
In summary, the whitening product has significant white-skinned face function, i.e., with bright color and desalinates the dual of color spot Effect.
Based on above-mentioned, it is an advantage of the current invention that the cleawhite over-night essences utilizes metallothionein, Trenaxmine and hyalomitome Acid, can exclude lead, mercury, hormone and the skin rubbish toxin of skin bottom, the light spot of whitening effect, anti-inflammatory anti-acne, replenishing water and preserving moisture, take off Red reparation, the cleawhite over-night essences are played a role using the biological enzymolysis product of licorice as main active component, collaboration, suppression Melanin generation and migration processed reach the effect of skin whitening, contain ursin elite, rich in abundant vitamin A, E and albumen Matter and other trace elements, have stronger infiltration repair ability, wake up skin life, and sebum film is rebuild in protection, and softening is thick Weight cuticula;The pigment color spot in skin corium can be desalinated simultaneously, accelerate melanin to decompose and drain, so as to reduce skin pigment Deposition, skin whitening, is a pure natural skin-protection product of the high-tech imitated entirely.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention All any modification, equivalent and improvement made within refreshing and principle etc., should be included in the scope of the protection.

Claims (4)

1. a kind of whitening spot-removing special efficacy Essence, it is characterised in that its formula is made up of according to parts by weight the following raw material:
Metallothionein 50-60 parts, Trenaxmine 3-5 parts are hyaluronic acid 13-19 parts, Hydrolyzed Collagen 5-10 parts, top natural Skin whitening, moisturizing factor 11-15 parts, amino acid humectant 1-5 parts, licorice 8-14 parts, olive oil 1-3 parts, ursin 3-6 Part, lecithin wax 1-5 parts, bigarabe flower essential oil 5-8 parts, brown alga gel 1-9 parts, -3 parts of Cer EOS.
2. a kind of whitening spot-removing special efficacy Essence according to claim 1, it is characterised in that it is formulated according to parts by weight It is made up of the following raw material:
50 parts of metallothionein, 3 parts of Trenaxmine, 13 parts of hyaluronic acid, 5 parts of Hydrolyzed Collagen, top natural whiting moisturizing because 11 parts of son, 1 part of amino acid humectant, 8 parts of licorice, 1 part of olive oil, 3 parts of ursin, 1 part of lecithin wax, bigarabe flower essential oil 5 parts, 1 part of brown alga gel, Cer EOS part.
3. a kind of whitening spot-removing special efficacy Essence according to claim 1, it is characterised in that it is formulated according to parts by weight It is made up of the following raw material:
60 parts of metallothionein, 5 parts of Trenaxmine, 19 parts of hyaluronic acid, 10 parts of Hydrolyzed Collagen, top natural whiting moisturizing because 15 parts of son, 5 parts of amino acid humectant, 14 parts of licorice, 3 parts of olive oil, 6 parts of ursin, 5 parts of lecithin wax, bigarabe anthosin 8 parts of oil, 9 parts of brown alga gel, Cer NP part.
4. a kind of whitening spot-removing special efficacy Essence according to claim 1, it is characterised in that its preparation method includes as follows Step:
(1) according to recipe configuration raw material, by except top natural whiting moisturizing factor, amino acid humectant and licorice Other raw materials are simultaneously added in reaction pot, are heated to 78-82 DEG C while stirring, until being uniformly dispersed;
(2) 48-55 DEG C is cooled to, and adds licorice, continues to obtain preliminary Essence after stirring 30-40 minutes;
(3) room temperature is cooled to, top natural whiting moisturizing factor, amino acid humectant is added, stirs, and low-grade fever 5-7 Minute, normal temperature is subsequently cooled to, obtains Essence.
CN201610675303.2A 2016-08-11 2016-08-11 A kind of whitening spot-removing special efficacy Essence Pending CN107714525A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108837145A (en) * 2018-08-21 2018-11-20 武汉麦考勒斐林生物科技有限公司 A kind of compound metallothionein pill of lead discharging mercury and preparation method thereof
CN108852898A (en) * 2018-08-21 2018-11-23 武汉麦考勒斐林生物科技有限公司 Compound metallothionein lightening compositions and preparation method thereof
CN110090169A (en) * 2019-05-27 2019-08-06 广州瑞诗生物科技有限公司 A kind of hyaluronic acid nti-freckle gel
CN110547974A (en) * 2019-10-25 2019-12-10 张赞红 beauty essence prepared from composite mineral water and preparation method thereof
CN111249203A (en) * 2020-03-31 2020-06-09 重庆程熙医疗美容研究有限公司 Skin care composition formula
CN111840150A (en) * 2019-04-28 2020-10-30 郑子玉 Spot-fading acne-removing skin care powder
CN114601770A (en) * 2022-04-24 2022-06-10 广州市白云莱茵化妆品厂 Skin care product with acne removing and whitening effects

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108837145A (en) * 2018-08-21 2018-11-20 武汉麦考勒斐林生物科技有限公司 A kind of compound metallothionein pill of lead discharging mercury and preparation method thereof
CN108852898A (en) * 2018-08-21 2018-11-23 武汉麦考勒斐林生物科技有限公司 Compound metallothionein lightening compositions and preparation method thereof
CN111840150A (en) * 2019-04-28 2020-10-30 郑子玉 Spot-fading acne-removing skin care powder
CN110090169A (en) * 2019-05-27 2019-08-06 广州瑞诗生物科技有限公司 A kind of hyaluronic acid nti-freckle gel
CN110547974A (en) * 2019-10-25 2019-12-10 张赞红 beauty essence prepared from composite mineral water and preparation method thereof
CN111249203A (en) * 2020-03-31 2020-06-09 重庆程熙医疗美容研究有限公司 Skin care composition formula
CN114601770A (en) * 2022-04-24 2022-06-10 广州市白云莱茵化妆品厂 Skin care product with acne removing and whitening effects

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Application publication date: 20180223