CN107699443B - Application of spartina alterniflora extract in preparation of functional product of cordial for reducing hyperuricemia - Google Patents
Application of spartina alterniflora extract in preparation of functional product of cordial for reducing hyperuricemia Download PDFInfo
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- 239000000284 extract Substances 0.000 title claims abstract description 26
- 235000020354 squash Nutrition 0.000 title claims abstract description 22
- 201000001431 Hyperuricemia Diseases 0.000 title description 10
- 238000002360 preparation method Methods 0.000 title description 4
- 241000982152 Kosteletzkya virginica Species 0.000 claims abstract description 29
- 239000000843 powder Substances 0.000 claims description 23
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 13
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 13
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention belongs to the technical field of plant-derived cordial products. In particular to application of spartina alterniflora and kosteletzkya virginica root tuber in preparing functional cordial. The invention adds the above-ground part of the spartina alterniflora raw grass or spartina alterniflora extract, the kosteletzkya virginica root tuber or the extract thereof into the white spirit according to a certain proportion to prepare the liqueur. The research of the invention shows that the spartina alterniflora-kosteletzkya virginica cordial has bright yellow color and pleasant flavor, and has the effects of resisting gout, helping sleep, sobering and the like.
Description
Technical Field
The invention belongs to the technical field of plant-derived cordial products. In particular to the application of spartina alterniflora or the extract thereof and Kosteletzkya virginica root tuber or the extract thereof in preparing cordial with certain functions.
Background
Spartina alterniflora and Kosteletzkya virginica are native to the United states and introduced into China in 1979 and 1993, respectively. Kosteletzkya virginica root tuber and leaf or leaf extract as salt-tolerant economic plant has been used for preparing liqueur, and has light yellow color and flavor peculiar to kosteletzkya virginica. In the resource utilization of spartina alterniflora, no report is made on the development of functional cordial with flavor.
The over-ground raw grass of spartina alterniflora contains 10.52 percent of total polysaccharide, 4.46 percent of total saponin and 0.81 percent of total flavone; the Kosteletzkya virginica root tuber contains 28.32 percent of total polysaccharide, 3.45 percent of total saponin and 0.48 percent of total flavone. Related researches find that the extracts of the spartina alterniflora and the kosteletzkya virginica have the effects of improving the immunity of animals and human beings, reducing blood fat, resisting inflammation and the like.
Disclosure of Invention
The invention provides a new application of spartina alterniflora, kosteletzkya virginica and extracts thereof in preparing cordial products, and develops a crowd study on the activity of spartina alterniflora-kosteletzkya virginica cordial.
The specific technical scheme of the invention is as follows:
use of spartina alterniflora in the preparation of functional liqueur products. The functional product is a food or a health product.
The spartina alterniflora can be raw grass or an extract thereof, the extract is preferably a water extract, and can be prepared into a concentrated solution or a dry product after being dried.
The spartina alterniflora extract is prepared by the following method: collecting aerial parts of spartina alterniflora, leaching with water, and concentrating into concentrated solution for later use; or further drying the concentrated solution.
The aqueous extract of spartina alterniflora can be prepared using the protocol disclosed in application No. 201510266409.2.
The application of the invention can also prepare the functional product of the cordial by using the spartina alterniflora and the kosteletzkya virginica root tuber together. The Kosteletzkya virginica root tuber is a dry root tuber or an extract thereof. The extract is preferably water extract, and can be made into concentrated solution or dried product.
The Kosteletzkya virginica root tuber extract is prepared by adopting the following method: collecting Kosteletzkya virginica root tuber, cleaning, air drying, slicing, further oven drying, pulverizing into powder, further extracting with water, and concentrating to obtain concentrated solution; or further drying the concentrated solution.
Another object of the present invention is to provide a functional cordial containing spartina alterniflora or an extract thereof.
The above cordial may also contain Kosteletzkya virginica root tuber or its extract.
The cordial provided by the invention has the weight ratio of the spartina alterniflora or the kosteletzkya virginica root tuber to the base wine of 1:10, and the weight ratio of the spartina alterniflora extract or the kosteletzkya virginica root tuber extract to the base wine of 1: 100.
Hyperuricemia (HUA) refers to a condition of two fasting blood uric acid levels higher than 420. mu. mol/L in men and higher than 360. mu. mol/L in women under normal purine diet, which is called hyperuricemia.
Uric acid is the terminal metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia. The prevalence of the disease is influenced by various factors, and is related to heredity, sex, age, life style, dietary habits, drug treatment, economic development degree and the like. According to the reports of the prevalence rate of hyperuricemia in various places in recent years, about 1.2 hundred million hyperuricemia people in China currently account for about 10 percent of the total population, and the advanced age is middle-aged and old men and postmenopausal women, but the hyperuricemia is in a trend of being younger in recent years. Elevated blood uric acid is often found in gout, acute or chronic glomerulonephritis, renal tuberculosis, hydronephrosis, eclampsia, chronic leukemia, polycythemia, excessive intake of food containing nucleoprotein, uremic nephritis, liver disorders, chloroform and lead poisoning, hypothyroidism, multiple myeloma, leukemia, pregnancy reactions, polycythemia, etc. Therefore, the development of functional products for reducing the high blood uric acid has high clinical value.
The invention develops the crowd observation test of hyperuricemia drinking the spartina alterniflora juice wine and the spartina alterniflora-kostelezkya virginica juice wine, the blood uric acid is measured before and after the trial drinking, and the results show that the blood uric acid level of the tested crowd can be effectively reduced by drinking the spartina alterniflora juice wine and the spartina alterniflora-kostelezkya virginica juice wine according to the data before and after statistical treatment and comparison with a blank control group.
Detailed Description
The following examples illustrate specific steps of the present invention, but are not intended to limit the invention.
Terms used in the present invention generally have meanings commonly understood by those of ordinary skill in the art, unless otherwise specified.
The present invention is described in further detail below with reference to specific examples and with reference to the data. It will be understood that these examples are intended to illustrate the invention and are not intended to limit the scope of the invention in any way.
In the following examples, various procedures and methods not described in detail are conventional methods well known in the art.
Example 1 preparation of Spartina alterniflora-Kosteletzkya virginica cordial
1. Wine prepared from spartina alterniflora (L.) Merr-Kosteletzkya virginica root tuber (slice or powder)
1.1 raw materials: selecting Subei clean beach, harvesting aerial parts in 10-12 months per year, cleaning, air drying, and cutting into 2-3cm length. Selecting Kosteletzkya virginica planted in non-polluted salt soil of Subei, harvesting the Kosteletzkya virginica root tuber in 10-12 months per year, cleaning, air drying, and slicing into 2 × 3cm in size and 1cm in thickness for later use; or crushed to <100 mesh powder for use.
1.2, processing: weighing 2kg of spartina alterniflora raw grass, 2kg of the cut (or powder) of the root tuber of kosteletzkya virginica, and 40kg of 35-degree white spirit, processing and soaking for more than one week.
1.3 finished wine: filtering out the raw spartina alterniflora and the root tuber slices (or powder) of the kosteletzkya virginica to prepare the spartina alterniflora-kosteletzkya virginica alcoholic drink which is bright yellow, has special mellow flavor and is sweet and delicious.
2. Cordial prepared by dissolving refined powder of Spartina alterniflora and refined powder of Kosteletzkya virginica root tuber
2.1, raw materials: the spartina alterniflora fine powder is prepared by selecting standard spartina alterniflora raw material, extracting with water, concentrating, filtering, and spray drying to obtain powder. The Kosteletzkya virginica root tuber fine powder is prepared by selecting standard Kosteletzkya virginica root tuber slices (or powder), extracting with water, concentrating, filtering, and spray-drying to obtain powder.
2.2 dissolution: weighing 200g of spartina alterniflora fine powder, adding 200g of kosteletzkya virginica root slice fine powder, adding 40kg of 35-degree white spirit, and dissolving for 3-4 times within 2-3h to promote full dissolution.
2.3 finished wine: after 2-3h, the refined powder is completely dissolved in the wine to prepare the spartina alterniflora-kosteletzkya virginica cordial, and the wine is bright yellow, has special mellow flavor, is sweet and delicious, and has better transparency than the processed wine.
3. Independently dissolving cordial from spartina alterniflora fine powder
3.1 raw materials: refined powder of spartina alterniflora
3.2 dissolution: weighing 400g of spartina alterniflora fine powder, adding 40kg of 35-degree white spirit, and dissolving for 2.2 times.
3.3 finished wine: 2-3h later, the refined powder is completely dissolved in the wine to prepare the Spartina alterniflora juice wine, the single-component juice wine is light yellow, has light specific mellow fragrance and slightly inferior palatability to the Spartina alterniflora-Kosteletzkya virginica juice wine.
Example 2 test of the population on the trial drinking of Spartina alterniflora-Kosteletzkya virginica juice wine
A30 ginseng additional test is performed on male volunteer test drinkers with common drinking habits and high blood uric acid in Liuhe district of Nanjing, wherein 10 people drink the spartina alterniflora fine powder prepared by the method 2 in the embodiment 1 of the invention, namely the Kosteletzkya virginica root tuber fine powder to dissolve the cordial, 10 people drink the spartina alterniflora fine powder prepared by the method 3 in the embodiment 1 of the invention to dissolve the cordial alone (each person drinks 2-2.5 cordial every day), and 10 people drink other white spirit according to the common habits (each person is advised to drink 2-2.5 white spirit) for 45 days, wherein the common diet is kept during the test drinking, and no medicine is taken. Two kinds of liqueurs (liqueurs) were used for the test and were provided by the Nanjing Dongyuan winery. The trial drinker measures the blood uric acid once before and after drinking, and counts and processes the observation data.
1. Design of test groups
(1) Control group (regular drinking) 10 persons;
(2) drinking the spartina alterniflora juice group for 10 persons;
(3) the group of the spartina alterniflora-kosteletzkya virginica alcoholic drink was drunk for 10 persons.
2. The determination uses a Beckmann LX20 full-automatic biochemical analyzer to determine the blood uric acid index.
3. Statistical processing all data were processed through the Spss11.5 software package using one-way analysis of variance expressed as mean. + -. standard deviation (x. + -.s).
4. Results of the experiment
Blood uric acid measurement result of crowd drinking test-drinking spartina alterniflora-kosteletzkya virginica juice wine
Tests show that the serum uric acid level of both the group drinking the Spartina alterniflora juice and the group drinking the Spartina alterniflora-Kosteletzkya virginica juice are significantly reduced in the test time, while the control group in the experiment has no significant change before and after the test (the results are shown in Table 1).
TABLE 1 influence of drinking Spartina alterniflora-Kosteletzkya virginica juice wine on blood uric acid of trial drinking crowd
P < 0.01%, with very significant differences between the two previous and subsequent basic knowledge.
Claims (5)
1. The application of the spartina alterniflora extract in preparing functional products of the cordial for reducing the uric acid in high blood levels is characterized in that the spartina alterniflora extract is prepared by the following method: collecting aerial parts of spartina alterniflora, leaching with water, and concentrating into concentrated solution for later use; or further drying the concentrated solution.
2. The use according to claim 1, characterized in that the functional product is a food or health product.
3. Use according to claim 1 or 2, characterized in that the extract of spartina alterniflora is used together with the root tuber of kosteletzkya virginica to produce a functional liqueur product.
4. Use according to claim 3, characterized in that the Kosteletzkya virginica root tuber is a dried root tuber or an extract thereof.
5. The use as claimed in claim 4, wherein said kosteletzkya virginica root tuber extract is prepared by the following method: collecting Kosteletzkya virginica root tuber, cleaning, air drying, slicing, further oven drying, pulverizing into powder, further extracting with water, and concentrating to obtain concentrated solution; or further drying the concentrated solution.
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| CN110669621A (en) * | 2019-10-17 | 2020-01-10 | 南京迪维奥医药科技有限公司 | Rice straw biological mineral liquid kudzu root wine and preparation method thereof |
| CN110713873A (en) * | 2019-11-13 | 2020-01-21 | 陈琳 | Preparation method of bio-mineral liquor nitraria tangutorum bobr fruit wine containing rice grass |
| CN113278488A (en) * | 2021-05-19 | 2021-08-20 | 中酌酒业(江苏)股份有限公司 | Spartina alterniflora spleen-tonifying and stomach-nourishing dried orange peel wine medicine-decocting pot and preparation process thereof |
| CN113293083A (en) * | 2021-05-19 | 2021-08-24 | 中酌酒业(江苏)股份有限公司 | Spartina alterniflora immune liver-protecting ganoderma lucidum wine medicine decocting pot and preparation process thereof |
| CN113308327A (en) * | 2021-05-19 | 2021-08-27 | 中酌酒业(江苏)股份有限公司 | Spartina alterniflora yin-nourishing and yang-tonifying dendrobium wine medicine decocting pot and preparation process thereof |
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| CN105837345A (en) * | 2016-05-31 | 2016-08-10 | 博白县那林镇菌兴家庭农场 | Auricularia polytricha culture medium and preparation method thereof |
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| CN103540491A (en) * | 2012-07-14 | 2014-01-29 | 南京大学连云港高新技术研究院 | Fresh Kosteletzkya virginica root tuber wine and preparation method thereof |
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