CN107693776A - 用于治疗无效性红细胞生成的方法和组合物 - Google Patents

用于治疗无效性红细胞生成的方法和组合物 Download PDF

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Publication number
CN107693776A
CN107693776A CN201711069457.8A CN201711069457A CN107693776A CN 107693776 A CN107693776 A CN 107693776A CN 201711069457 A CN201711069457 A CN 201711069457A CN 107693776 A CN107693776 A CN 107693776A
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CN
China
Prior art keywords
actriib
gdf trap
seq
polypeptide
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711069457.8A
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English (en)
Chinese (zh)
Inventor
J.斯拉
R.S.皮萨尔
R.库马
N.V.S.R.苏拉加尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acceleron Pharma Inc
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Acceleron Pharma Inc
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Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of CN107693776A publication Critical patent/CN107693776A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201711069457.8A 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物 Pending CN107693776A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161547932P 2011-10-17 2011-10-17
US61/547932 2011-10-17
CN201280061672.2A CN103987403B (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280061672.2A Division CN103987403B (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

Publications (1)

Publication Number Publication Date
CN107693776A true CN107693776A (zh) 2018-02-16

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201280061672.2A Active CN103987403B (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物
CN201711069457.8A Pending CN107693776A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物
CN201711069431.3A Pending CN107837390A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

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CN201711069431.3A Pending CN107837390A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

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Country Link
US (4) US20130243743A1 (enExample)
EP (3) EP2797620B1 (enExample)
JP (4) JP6092883B2 (enExample)
KR (4) KR102079482B1 (enExample)
CN (3) CN103987403B (enExample)
AU (4) AU2012326207B2 (enExample)
BR (3) BR122019023166B1 (enExample)
CA (1) CA2852683A1 (enExample)
DK (2) DK3875104T3 (enExample)
EA (2) EA202090053A3 (enExample)
ES (3) ES2741477T3 (enExample)
HK (2) HK1250341A1 (enExample)
WO (1) WO2013059347A1 (enExample)

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SG10201913747PA (en) 2015-04-22 2020-03-30 Biogen Ma Inc Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases
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Also Published As

Publication number Publication date
WO2013059347A1 (en) 2013-04-25
KR102079482B1 (ko) 2020-02-19
HK1252940A1 (zh) 2019-06-06
BR122019023174B1 (pt) 2021-02-23
US20170137791A1 (en) 2017-05-18
BR112014009528B1 (pt) 2020-12-29
EP2797620A4 (en) 2015-05-20
AU2018247262A1 (en) 2018-11-01
EP2797620B1 (en) 2019-04-24
KR20140084211A (ko) 2014-07-04
JP2020186277A (ja) 2020-11-19
JP2014530253A (ja) 2014-11-17
AU2017201580A1 (en) 2017-03-30
JP6796626B2 (ja) 2020-12-09
EA201490809A1 (ru) 2014-09-30
BR112014009528A8 (pt) 2019-12-10
EP3875104A1 (en) 2021-09-08
HK1203413A1 (en) 2015-10-30
CN107837390A (zh) 2018-03-27
JP6383821B2 (ja) 2018-08-29
JP2017101060A (ja) 2017-06-08
EP2797620A1 (en) 2014-11-05
KR20190105113A (ko) 2019-09-11
DK3875104T3 (da) 2025-02-03
AU2017201580B2 (en) 2018-07-12
JP2018165287A (ja) 2018-10-25
DK3520805T3 (da) 2021-04-19
KR20220075438A (ko) 2022-06-08
CA2852683A1 (en) 2013-04-25
BR122019023166B1 (pt) 2021-02-23
AU2020286229A1 (en) 2021-01-07
US20210207107A1 (en) 2021-07-08
AU2012326207A1 (en) 2014-05-15
CN103987403B (zh) 2017-12-01
BR112014009528A2 (pt) 2017-05-09
EP3875104B1 (en) 2025-01-22
HK1250341A1 (zh) 2018-12-14
US20130243743A1 (en) 2013-09-19
JP6092883B2 (ja) 2017-03-08
ES2869168T3 (es) 2021-10-25
EA202090053A2 (ru) 2020-04-30
EA034563B1 (ru) 2020-02-20
AU2018247262B2 (en) 2020-12-24
KR20200019261A (ko) 2020-02-21
EP3520805A1 (en) 2019-08-07
AU2012326207B2 (en) 2016-12-15
CN103987403A (zh) 2014-08-13
ES2741477T3 (es) 2020-02-11
EA202090053A3 (ru) 2020-06-30
US20170327800A1 (en) 2017-11-16
ES3010483T3 (en) 2025-04-03
EP3520805B1 (en) 2021-03-10

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