CN103987403B - 用于治疗无效性红细胞生成的方法和组合物 - Google Patents

用于治疗无效性红细胞生成的方法和组合物 Download PDF

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Publication number
CN103987403B
CN103987403B CN201280061672.2A CN201280061672A CN103987403B CN 103987403 B CN103987403 B CN 103987403B CN 201280061672 A CN201280061672 A CN 201280061672A CN 103987403 B CN103987403 B CN 103987403B
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actriib
purposes
amino acid
gdf trap
polypeptide
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CN201280061672.2A
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Chinese (zh)
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CN103987403A (zh
Inventor
J.斯拉
R.S.皮萨尔
R.库马
N.V.S.R.苏拉加尼
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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Priority to CN201711069431.3A priority Critical patent/CN107837390A/zh
Priority to CN201711069457.8A priority patent/CN107693776A/zh
Publication of CN103987403A publication Critical patent/CN103987403A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201280061672.2A 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物 Active CN103987403B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201711069431.3A CN107837390A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物
CN201711069457.8A CN107693776A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161547932P 2011-10-17 2011-10-17
US61/547932 2011-10-17
PCT/US2012/060650 WO2013059347A1 (en) 2011-10-17 2012-10-17 Methods and compositions for treating ineffective erythropoiesis

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201711069431.3A Division CN107837390A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物
CN201711069457.8A Division CN107693776A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

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CN103987403A CN103987403A (zh) 2014-08-13
CN103987403B true CN103987403B (zh) 2017-12-01

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CN201711069431.3A Pending CN107837390A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物
CN201280061672.2A Active CN103987403B (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物
CN201711069457.8A Pending CN107693776A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

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US (4) US20130243743A1 (enExample)
EP (3) EP2797620B1 (enExample)
JP (4) JP6092883B2 (enExample)
KR (4) KR102079482B1 (enExample)
CN (3) CN107837390A (enExample)
AU (4) AU2012326207B2 (enExample)
BR (3) BR112014009528B1 (enExample)
CA (1) CA2852683A1 (enExample)
DK (2) DK3875104T3 (enExample)
EA (2) EA034563B1 (enExample)
ES (3) ES3010483T3 (enExample)
HK (2) HK1250341A1 (enExample)
WO (1) WO2013059347A1 (enExample)

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US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
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JP6649895B2 (ja) * 2014-04-18 2020-02-19 アクセルロン ファーマ， インコーポレイテッド 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法
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US20170137791A1 (en) 2017-05-18
US20170327800A1 (en) 2017-11-16
AU2017201580A1 (en) 2017-03-30
EP3520805B1 (en) 2021-03-10
CN107693776A (zh) 2018-02-16
EP2797620A4 (en) 2015-05-20
AU2017201580B2 (en) 2018-07-12
CN103987403A (zh) 2014-08-13
BR122019023166B1 (pt) 2021-02-23
US20130243743A1 (en) 2013-09-19
JP6796626B2 (ja) 2020-12-09
DK3520805T3 (da) 2021-04-19
AU2018247262B2 (en) 2020-12-24
CN107837390A (zh) 2018-03-27
EA202090053A2 (ru) 2020-04-30
EA202090053A3 (ru) 2020-06-30
BR112014009528B1 (pt) 2020-12-29
HK1203413A1 (en) 2015-10-30
KR20220075438A (ko) 2022-06-08
AU2012326207A1 (en) 2014-05-15
EA201490809A1 (ru) 2014-09-30
EP3520805A1 (en) 2019-08-07
EP2797620A1 (en) 2014-11-05
AU2020286229A1 (en) 2021-01-07
KR102079482B1 (ko) 2020-02-19
BR122019023174B1 (pt) 2021-02-23
KR20190105113A (ko) 2019-09-11
BR112014009528A8 (pt) 2019-12-10
EP2797620B1 (en) 2019-04-24
EA034563B1 (ru) 2020-02-20
WO2013059347A1 (en) 2013-04-25
JP2014530253A (ja) 2014-11-17
JP2020186277A (ja) 2020-11-19
ES3010483T3 (en) 2025-04-03
US20210207107A1 (en) 2021-07-08
AU2012326207B2 (en) 2016-12-15
JP6092883B2 (ja) 2017-03-08
EP3875104B1 (en) 2025-01-22
HK1252940A1 (zh) 2019-06-06
AU2018247262A1 (en) 2018-11-01
ES2869168T3 (es) 2021-10-25
DK3875104T3 (da) 2025-02-03
CA2852683A1 (en) 2013-04-25
KR20140084211A (ko) 2014-07-04
KR20200019261A (ko) 2020-02-21
JP6383821B2 (ja) 2018-08-29
ES2741477T3 (es) 2020-02-11
JP2018165287A (ja) 2018-10-25
HK1250341A1 (zh) 2018-12-14
JP2017101060A (ja) 2017-06-08
EP3875104A1 (en) 2021-09-08
BR112014009528A2 (pt) 2017-05-09

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