CN1076855A - A kind of preparation method of natural zinc tonic - Google Patents
A kind of preparation method of natural zinc tonic Download PDFInfo
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- CN1076855A CN1076855A CN92106452A CN92106452A CN1076855A CN 1076855 A CN1076855 A CN 1076855A CN 92106452 A CN92106452 A CN 92106452A CN 92106452 A CN92106452 A CN 92106452A CN 1076855 A CN1076855 A CN 1076855A
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- calamina
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- natural zinc
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Abstract
The present invention is a kind of preparation method of natural zinc tonic.With Chinese medicine Calamina calcining, be ground into powder, with after an amount of vinegar mixes,, it is fully reacted again by heating, precipitate then, filter, concentrate, dry, protection against the tide storage, standby.Except that the chemical compound that contains a large amount of soluble in water and zinc that easily absorbed by body, also contain trace element such as ferrum in this natural zinc tonic, can be used as zinc supplement, the control zinc deficiency can be prevented and treated iron deficiency anemia again.Also have, abundant raw material, preparation are simple, cheap.
Description
The invention belongs to the preparation method of Chinese medicine medicine
Traditional method is that Calamina is forged, and quench in vinegar five times is as astringency.But the Calamina of Bao Zhiing is insoluble in water in this way, and impurity is a lot, can only external, should not take orally as zinc supplement.On the other hand, medicines such as at present commercially available zinc sulfate and zinc acetate all are the simple medicines of artificial chemosynthesis, and as zinc supplement for oral administration, its toxic and side effects is more obvious.
Current in the child, especially among the child in the 2-6 of developing country year, there are 2/3rds patients that in various degree zinc deficiency is arranged.The objective of the invention is to utilize natural Calamina, prepare a kind of malicious pair and do less and contain the blended zinc supplement of various trace elements.
Preparation method
Get the raw materials ready
Calamina: produce in Qingdao, Jinan, canescence, and light weight, tasteless, putting has the absorption sense on the tongue.Contain about 90% zinc carbonate in interior
Vinegar: common vinegar, contain about 4% acetic acid in interior.
Pulverize, forge the stir-fry Calamina
Calamina is pulverized, forged stir-fry, can make the part zinc carbonate become zinc oxide, be easy to react with vinegar with cast iron pan.
With Calamina (calcined and quenched) powder and vinegar Hybrid Heating, make it abundant reaction.
The ratio of Calamina (calcined and quenched) powder and vinegar can be calculated by following formula:
125 2×60
100 X X=(100 * 2 * 60)/the 125=96(gram)
Be per 125 gram carbon vinegar zinc can with 96 gram acetic acid reactions.
Approximately contain in the Calamina that produce in Jinan or Qingdao 90% carbon vinegar zinc, so, 125 ÷ 90%=138.9(gram), contain 125 gram carbon vinegar zinc in promptly about 130 gram Calaminas.
Approximately contain 4% acetic acid in the common vinegar, therefore, contain 96 gram acetic acid (96 ÷ 4%=2400) in about 2400 gram vinegars
That is to say that about 139 gram Calaminas can fully react with about 2400 gram vinegars.
Calamina (calcined and quenched) powder and vinegar are fully mixed, place in stainless-steel pan or the cast iron pan, heated and boiled 30 to 60 minutes.
With boiling liquid precipitation, filtration.
Boiling liquid is left standstill, and room temperature precipitates 12-24 hour down, gets supernatant liquid filtering then, uses common filter funnel, adopts the filter paper filtering method to get final product.
Filtered solution is concentrated
Adopt the heating evaporation concentration method to get final product, use the rustless steel jacketed pan usually, feed Steam Heating.Make the concentrate drying, moistureproof storage is standby.
Adopt calorstat or frozen drying method all can.The dry thing of vinegar Calamina(processed) is the pitchy bulk, and is soluble in water.Salty in the mouth, acid, suffering have stimulation slightly to oral mucosa, and the moisture absorption answers protection against the tide to stock easily.
The component analysis of Calamina
| Composition | Zn(%) | Fe(%) | Ca(Hg/g) | Mg(Hg/g) | Mn(Hg/g) |
| Content | 48.7 | 0.111 | 830 | 290 | 50 |
The analysis of components of vinegar Calamina(processed)
| Composition | Organic (%) | Zn(%) | Fe(%) | Mn(%) |
| Content | 37.82 | 4.391 | 0.260 | 0.03 |
Mice median lethal dose(LD 50) (the LD of vinegar Calamina(processed)
50)
Get kunming mice male and female half and half, body weight 20 gram is made into the vinegar Calamina(processed) 25% solution and again mice is divided into 6 groups at random, each 5 of every group of male and female.25% the disposable filling stomach of Calamina solution 0.8ml/209 body weight was observed 7 days, and room temperature is 20.5-21 ℃, and water food ginseng 5 is fed, and dosage is to array distance 0.0969.Mice begins to show as the autonomic activities minimizing as a result, and limb is soft unable, and it is motionless to close one's eyes then, and final breathing is slow shallow and dead.Dissect dead Mus, perusal does not see that internal organs are unusual.
Each is organized mortality rate and sees the following form:
Group mice (only) dosage (mg/20g) dosage logarithm death (only) mortality rate
1 10 200.0 2.3010 10 1.0
2 10 160.0 2.2041 9 0.9
3 10 128.0 2.1072 9 0.9
4 10 102.4 2.0103 3 0.3
5 10 81.8 1.9134 1 0.1
6 10 65.5 1.8165 0 0
According to last table statistics, press Sun Shi improvement karber's method and calculate gained LD
50=5.474g/kg.
Again according to clinic trial dosage prediction equation: least effective dose (LED) is 5.474 * (1/10) * 60 * 0.11=3.612(gram), maximal effective dose is 5.474 * (1/3) * 60 * 0.11=11.922(gram) (0.11 in the formula is mice and people's conversion coefficient).
The content of several heavy metal species in the vinegar Calamina(processed)
| Project | Plumbous (pb) | Cobalt (Co) | Cadmium (Cd) | Chromium (Cr) |
| Content (vg/g) | 25 | 1.25 | 0.75 | 1.7 |
According to measurement result, in the contained several heavy metal species of vinegar Calamina(processed), plumbous content is the highest, in promptly every gram vinegar Calamina(processed) leaded 0.025 milligram.Oral vinegar Calamina(processed), the adult measures available 3-10 gram every day, if in maximal effective dose 10 grams be, then the plumbous amount of absorption every day is 0.25 milligram.
Regulation in " food hygienic standard " of Ministry of Public Health promulgation, in drink, milk powder, sweet breast, Sal, the monosodium glutamate, the lead tolerance of per kilogram must not be above 1 milligram; In liquor spirituous and system wine, vinegar, the soy sauce, every liter content is no more than 5 milligrams.This shows that every day, oral 3-5 gram even 10 gram vinegar Calamina(processed) at all needn't be worried too much to saturnine problem.
Use-case
The child of the third world especially in the child of 2-6 between year, suffers from zinc deficiency person in various degree, unexpectedly up to more than 2/3rds.The cardinal symptom of zinc deficiency has inappetence, even anorexia, refusing to eat, growth retardation, repeated infection, allotriophagy, recurrent oral ulceration and mucocutaneous place ulcer, intestinal originality acrodermatitis.Rheumatoid arthritis, poor wound healing etc.Chemical drugss such as the zinc sulfate of current clinical use, zinc acetate, toxic and side effects is bigger.
We once got 600 milligrams of vinegar Calamina(processed), and sugaring 20 grams add water to 100 milliliters again, make zinc-contained syrup, and name is said " my child's think of ", and each oral 10 milliliters, every day 3 times.By clinical preliminary observation, child's zinc deficiency symptom be improved significantly, do not find any untoward reaction, also can be used as food additive, treatment child zinc deficiency.
Claims (5)
1, a kind of preparation method of natural zinc tonic, it is characterized in that utilizing natural top grade Calamina and vinegar hybrid reaction, heating and temperature control is at 100 ℃, response time was respectively 30-60 minute, through precipitation, filtration, drying, be prepared into the vinegar Calamina(processed) that is rich in natural zinc compound soluble in water.
2, the preparation method of a kind of natural zinc tonic according to claim 1 it is characterized in that the reaction of Calamina and vinegar Hybrid Heating is preceding fully calcined with Calamina, and pulverizing is powder.
3, the preparation method of a kind of natural zinc tonic according to claim 1 is characterized in that Calamina and vinegar Hybrid Heating utensil are stainless-steel pan or cast iron pan.
4, the preparation method of a kind of natural zinc tonic according to claim 1 is characterized in that reacting by heating boiled 30-60 minute.
5, the preparation method of a kind of natural zinc tonic according to claim 1 is characterized in that boiling liquid precipitation about 24 hours, gets behind the supernatant liquid filtering dryly again, and protection against the tide is stocked.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92106452A CN1076855A (en) | 1992-03-30 | 1992-03-30 | A kind of preparation method of natural zinc tonic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92106452A CN1076855A (en) | 1992-03-30 | 1992-03-30 | A kind of preparation method of natural zinc tonic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1076855A true CN1076855A (en) | 1993-10-06 |
Family
ID=4942123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92106452A Pending CN1076855A (en) | 1992-03-30 | 1992-03-30 | A kind of preparation method of natural zinc tonic |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1076855A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1321646C (en) * | 2005-05-18 | 2007-06-20 | 浙江大学 | Oral zinc reinforcing agent using hydrotalcite as carrier, its preparation and using method thereof |
-
1992
- 1992-03-30 CN CN92106452A patent/CN1076855A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1321646C (en) * | 2005-05-18 | 2007-06-20 | 浙江大学 | Oral zinc reinforcing agent using hydrotalcite as carrier, its preparation and using method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |