CN107683283B - Bace1抑制剂 - Google Patents

Bace1抑制剂 Download PDF

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Publication number
CN107683283B
CN107683283B CN201680031828.0A CN201680031828A CN107683283B CN 107683283 B CN107683283 B CN 107683283B CN 201680031828 A CN201680031828 A CN 201680031828A CN 107683283 B CN107683283 B CN 107683283B
Authority
CN
China
Prior art keywords
fluorophenyl
thiazin
trimethyl
oxo
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201680031828.0A
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English (en)
Chinese (zh)
Other versions
CN107683283A (zh
Inventor
比约恩·巴特尔斯
科西莫·多伦特
沃尔夫冈·古帕
沃尔夫冈·哈普
乌尔丽克·奥布斯特·森德
沃尔特·维凡
托马斯·沃尔特林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN107683283A publication Critical patent/CN107683283A/zh
Application granted granted Critical
Publication of CN107683283B publication Critical patent/CN107683283B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680031828.0A 2015-08-12 2016-08-08 Bace1抑制剂 Expired - Fee Related CN107683283B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15180767.4 2015-08-12
EP15180767 2015-08-12
PCT/EP2016/068830 WO2017025491A1 (en) 2015-08-12 2016-08-08 Bace1 inhibitors

Publications (2)

Publication Number Publication Date
CN107683283A CN107683283A (zh) 2018-02-09
CN107683283B true CN107683283B (zh) 2021-05-18

Family

ID=53835951

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680031828.0A Expired - Fee Related CN107683283B (zh) 2015-08-12 2016-08-08 Bace1抑制剂

Country Status (5)

Country Link
US (2) US10246468B2 (enExample)
EP (1) EP3334742B1 (enExample)
JP (1) JP6895424B2 (enExample)
CN (1) CN107683283B (enExample)
WO (1) WO2017025491A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10246468B2 (en) * 2015-08-12 2019-04-02 Hoffmann-La Roche Inc. BACE1 inhibitors
CN118846110A (zh) 2018-09-06 2024-10-29 第一三共株式会社 抗体药物偶联物
US11452848B2 (en) 2019-04-17 2022-09-27 Bard Access Systems, Inc. Catheter securement device including extended anchor pad and release liner clasping features
CN112791078B (zh) 2019-11-13 2022-12-06 润佳（苏州）医药科技有限公司 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途
KR20250168210A (ko) 2023-02-16 2025-12-02 가셔브룸 바이오, 인크. 헤테로시클릭 glp-1 효능제

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013174781A1 (en) * 2012-05-24 2013-11-28 F. Hoffmann-La Roche Ag 5-amino[1,4]thiazines as bace 1 inhibitors
WO2014114532A1 (en) * 2013-01-22 2014-07-31 F. Hoffmann-La Roche Ag Fluoro-[1,3]oxazines as bace1 inhibitors
WO2014150331A1 (en) * 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. S-imino-s-oxo iminothiazine compounds as bace inhibitors, compositions, and their use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2014111055A (ru) * 2011-08-22 2015-09-27 Мерк Шарп И Доум Корп. 2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение
CN104507950B (zh) * 2012-05-21 2017-03-22 拜耳医药股份有限公司 噻吩并嘧啶
US9605006B2 (en) * 2013-12-20 2017-03-28 Hoffmann-La Roche Inc. 5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines
CN106661053B (zh) * 2014-07-25 2019-07-12 豪夫迈·罗氏有限公司 吡啶基-三氮杂二环类化合物
JP6568937B2 (ja) * 2014-10-10 2019-08-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂａｃｅ１阻害剤
WO2016071211A1 (en) * 2014-11-03 2016-05-12 F. Hoffmann-La Roche Ag Bace1 inhibitors
US10246468B2 (en) * 2015-08-12 2019-04-02 Hoffmann-La Roche Inc. BACE1 inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013174781A1 (en) * 2012-05-24 2013-11-28 F. Hoffmann-La Roche Ag 5-amino[1,4]thiazines as bace 1 inhibitors
WO2014114532A1 (en) * 2013-01-22 2014-07-31 F. Hoffmann-La Roche Ag Fluoro-[1,3]oxazines as bace1 inhibitors
WO2014150331A1 (en) * 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. S-imino-s-oxo iminothiazine compounds as bace inhibitors, compositions, and their use

Also Published As

Publication number Publication date
CN107683283A (zh) 2018-02-09
US10246468B2 (en) 2019-04-02
JP2018522915A (ja) 2018-08-16
US20190270757A1 (en) 2019-09-05
JP6895424B2 (ja) 2021-06-30
EP3334742B1 (en) 2019-05-08
US20190002476A1 (en) 2019-01-03
US10696691B2 (en) 2020-06-30
EP3334742A1 (en) 2018-06-20
WO2017025491A1 (en) 2017-02-16

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