JP6895424B2 - Ｂａｃｅ１阻害剤 - Google Patents
Ｂａｃｅ１阻害剤 Download PDFInfo
- Publication number
- JP6895424B2 JP6895424B2 JP2018506862A JP2018506862A JP6895424B2 JP 6895424 B2 JP6895424 B2 JP 6895424B2 JP 2018506862 A JP2018506862 A JP 2018506862A JP 2018506862 A JP2018506862 A JP 2018506862A JP 6895424 B2 JP6895424 B2 JP 6895424B2
- Authority
- JP
- Japan
- Prior art keywords
- fluorophenyl
- trimethyl
- tetrahydro
- isothiazolo
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- -1 ii) Independently Chemical group 0.000 claims description 335
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- 125000001424 substituent group Chemical group 0.000 claims description 27
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15180767.4 | 2015-08-12 | ||
| EP15180767 | 2015-08-12 | ||
| PCT/EP2016/068830 WO2017025491A1 (en) | 2015-08-12 | 2016-08-08 | Bace1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522915A JP2018522915A (ja) | 2018-08-16 |
| JP2018522915A5 JP2018522915A5 (enExample) | 2019-09-12 |
| JP6895424B2 true JP6895424B2 (ja) | 2021-06-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506862A Expired - Fee Related JP6895424B2 (ja) | 2015-08-12 | 2016-08-08 | Ｂａｃｅ１阻害剤 |
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|---|---|
| US (2) | US10246468B2 (enExample) |
| EP (1) | EP3334742B1 (enExample) |
| JP (1) | JP6895424B2 (enExample) |
| CN (1) | CN107683283B (enExample) |
| WO (1) | WO2017025491A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10246468B2 (en) * | 2015-08-12 | 2019-04-02 | Hoffmann-La Roche Inc. | BACE1 inhibitors |
| LT3848054T (lt) | 2018-09-06 | 2025-03-25 | Daiichi Sankyo Company, Limited | Ciklinių dinukleotidų darinių antikūno ir vaisto konjugatai |
| US11452848B2 (en) | 2019-04-17 | 2022-09-27 | Bard Access Systems, Inc. | Catheter securement device including extended anchor pad and release liner clasping features |
| CN112791078B (zh) | 2019-11-13 | 2022-12-06 | 润佳（苏州）医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途 |
| CN120957993A (zh) | 2023-02-16 | 2025-11-14 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20140054295A (ko) * | 2011-08-22 | 2014-05-08 | 머크 샤프 앤드 돔 코포레이션 | Bace 억제제로서의 2-스피로-치환된 이미노티아진 및 그의 모노- 및 디옥시드, 조성물 및 그의 용도 |
| CN104507950B (zh) * | 2012-05-21 | 2017-03-22 | 拜耳医药股份有限公司 | 噻吩并嘧啶 |
| AU2013265376B2 (en) * | 2012-05-24 | 2017-07-20 | F. Hoffmann-La Roche Ag | 5-amino[1,4]thiazines as BACE 1 inhibitors |
| BR112015016315A2 (pt) * | 2013-01-22 | 2017-07-11 | Hoffmann La Roche | fluoro-[1,3]oxazinas como inibidores de bace1 |
| EP2968357B1 (en) | 2013-03-15 | 2018-07-04 | Merck Sharp & Dohme Corp. | S-imino-s-oxo iminothiazine compounds as bace inhibitors, compositions, and their use |
| CN108690052A (zh) * | 2013-12-20 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 5-芳基-1-亚氨基-1-氧代-[1,2,4]噻二嗪 |
| CN106661053B (zh) * | 2014-07-25 | 2019-07-12 | 豪夫迈·罗氏有限公司 | 吡啶基-三氮杂二环类化合物 |
| US9540397B2 (en) * | 2014-10-10 | 2017-01-10 | Hoffmann-La Roche Inc. | BACE1 inhibitors |
| EP3215514B1 (en) * | 2014-11-03 | 2018-11-21 | F. Hoffmann-La Roche AG | Bace1 inhibitors |
| US10246468B2 (en) * | 2015-08-12 | 2019-04-02 | Hoffmann-La Roche Inc. | BACE1 inhibitors |
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2016
- 2016-08-08 US US15/735,890 patent/US10246468B2/en not_active Expired - Fee Related
- 2016-08-08 JP JP2018506862A patent/JP6895424B2/ja not_active Expired - Fee Related
- 2016-08-08 WO PCT/EP2016/068830 patent/WO2017025491A1/en not_active Ceased
- 2016-08-08 EP EP16754452.7A patent/EP3334742B1/en not_active Not-in-force
- 2016-08-08 CN CN201680031828.0A patent/CN107683283B/zh not_active Expired - Fee Related
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2019
- 2019-02-13 US US16/274,911 patent/US10696691B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017025491A1 (en) | 2017-02-16 |
| CN107683283B (zh) | 2021-05-18 |
| US10696691B2 (en) | 2020-06-30 |
| US10246468B2 (en) | 2019-04-02 |
| CN107683283A (zh) | 2018-02-09 |
| US20190270757A1 (en) | 2019-09-05 |
| EP3334742B1 (en) | 2019-05-08 |
| US20190002476A1 (en) | 2019-01-03 |
| EP3334742A1 (en) | 2018-06-20 |
| JP2018522915A (ja) | 2018-08-16 |
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