CN107668718A - A kind of preparation method of fritillary bulb tabletting - Google Patents
A kind of preparation method of fritillary bulb tabletting Download PDFInfo
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- CN107668718A CN107668718A CN201711120873.6A CN201711120873A CN107668718A CN 107668718 A CN107668718 A CN 107668718A CN 201711120873 A CN201711120873 A CN 201711120873A CN 107668718 A CN107668718 A CN 107668718A
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- fritillary bulb
- tabletting
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- decoction
- preparation
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- 241000935235 Fritillaria meleagris Species 0.000 title claims abstract description 106
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000000706 filtrate Substances 0.000 claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000002245 particle Substances 0.000 claims abstract description 20
- 238000001914 filtration Methods 0.000 claims abstract description 19
- 238000000643 oven drying Methods 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 7
- 238000012545 processing Methods 0.000 claims abstract description 7
- 235000020985 whole grains Nutrition 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 18
- 244000175448 Citrus madurensis Species 0.000 claims description 12
- 235000017317 Fortunella Nutrition 0.000 claims description 12
- 241000287420 Pyrus x nivalis Species 0.000 claims description 12
- 241000605372 Fritillaria Species 0.000 claims description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 9
- 239000008101 lactose Substances 0.000 claims description 9
- 235000019359 magnesium stearate Nutrition 0.000 claims description 9
- 229940041616 menthol Drugs 0.000 claims description 9
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 229920002774 Maltodextrin Polymers 0.000 claims description 5
- 239000005913 Maltodextrin Substances 0.000 claims description 5
- 229940035034 maltodextrin Drugs 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- 235000004936 Bromus mango Nutrition 0.000 claims description 3
- 235000005979 Citrus limon Nutrition 0.000 claims description 3
- 244000131522 Citrus pyriformis Species 0.000 claims description 3
- 244000060011 Cocos nucifera Species 0.000 claims description 3
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 3
- 240000007228 Mangifera indica Species 0.000 claims description 3
- 235000014826 Mangifera indica Nutrition 0.000 claims description 3
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 3
- 235000009184 Spondias indica Nutrition 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- 239000001630 malic acid Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- 239000004376 Sucralose Substances 0.000 claims description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 2
- 235000019408 sucralose Nutrition 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 240000002853 Nelumbo nucifera Species 0.000 claims 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 15
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 238000003860 storage Methods 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 description 9
- 230000001953 sensory effect Effects 0.000 description 6
- 235000015170 shellfish Nutrition 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000002932 luster Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241001547125 Fritillaria thunbergii Species 0.000 description 1
- 241001644291 Fritillaria ussuriensis Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- VQKFNUFAXTZWDK-UHFFFAOYSA-N alpha-methylfuran Natural products CC1=CC=CO1 VQKFNUFAXTZWDK-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000003864 humus Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of preparation method of fritillary bulb tabletting, comprise the following steps：Pretreatment：Fritillary bulb is cleaned with flowing water, then dried；Weigh：Claim to prefetch the fritillary bulb 50g after processing；Decoct：Add the water of 10 times of volumes of fritillary bulb for the first time, decoct 1h, filtering, retain filtrate and the dregs of a decoction；Second plus 6 times of volume of water of fritillary bulb, 1h is decocted, filtering, retains filtrate and the dregs of a decoction；Third time plus 5 times of water of fritillary bulb, 15min is decocted, filtering, retains filtrate and the dregs of a decoction；Merge concentration:It filtrate will merge three times, and be concentrated into 20g thick pastes；The dregs of a decoction are broken into after fine powder and are well mixed with thick paste, are pelletized after 20 mesh sieve net filtrations, then with oven drying, whole grain, obtain fritillary bulb particle；Auxiliary material mixing is added to adjust mouthfeel；Tabletting obtains fritillary bulb tabletting.The fritillary bulb tabletting of the present invention by improving existing method, manufactured tabletting, the small content of its drug dose is high, and mouthfeel is more preferable, take, be easy to carry, good effect, beneficial to quantitatively taking, beneficial to storage and transport.
Description
Technical field
The invention belongs to technical field of health care food, is related to a kind of preparation method of fritillary bulb tabletting.
Background technology
Fritillary bulb is liliaceous plant fritillary bulb Fritillaria ussuriensis Maxim. dry bulb.Flat shellfish
Female also known as level ground shellfish, fritillaria, flat shellfish.There are clearing heat and moistening lung, relieving cough and reducing sputum effect, be a kind of conventional Chinese medicine, with bulbus fritillariae cirrhosae, fritillaria thunbergii
Belong to Fritillaria together, but pharmaceutically have certain difference, be distributed mainly on Changbai Mountain arteries and veins and the Xiaoxinanlin Mountains south mountain of the Northeast
Area, main product Heilungkiang, Jilin, Liaoning and Shanxi, Shaanxi, Hebei etc. save.It is more long to plant history, present many areas start to plant
Training, benefit are rich.Wild flat shellfish likes the gas for the moistening that cools, and is grown in mountain area sylvan life more and river two sides humus is abundant, loose
Fertile, relatively moistening place；The flat shellfish of artificial cultivation likes loose fertile sandy loam, and clayed ground, sandy ground and low-lying land should not plant.
Fritillary bulb has a good clearing heat and moistening lung, relieving cough and reducing sputum effect, but the problem of due to extracting method, it is of the prior art flat
What the mouthfeel and drug effect of fritillaria tabletting played is not fine.
The content of the invention
The technical problems to be solved by the invention are in view of the shortcomings of the prior art, there is provided a kind of preparation of fritillary bulb tabletting
Method.The preparation method of the fritillary bulb tabletting of the present invention is by improving existing method, and manufactured tabletting, its drug dose is small to be contained
Amount is high, and mouthfeel is more preferable, take, be easy to carry, good effect, beneficial to quantitatively taking, beneficial to storage and transport.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of preparation method of fritillary bulb tabletting, comprises the following steps：
(1) pretreatment：Fritillary bulb is cleaned with flowing water, then dried；
(2) weigh：Claim to prefetch the fritillary bulb 50g after processing；
(3) decoct：Add the water of 10 times of volumes of fritillary bulb for the first time, decoct 1h, filtering, retain filtrate and the dregs of a decoction；It is for the second time plus flat
6 times of volume of water of fritillaria, 1h is decocted, filtering, retains filtrate and the dregs of a decoction；Third time plus 5 times of water of fritillary bulb, 15min is decocted, filtered,
Retain filtrate and the dregs of a decoction；
(4) concentration is merged:It filtrate will merge three times, and be concentrated into 20g thick pastes；The dregs of a decoction are broken into after fine powder and are well mixed with thick paste,
It is placed in wet granulator and is pelletized after 20 mesh sieve net filtrations, then with oven drying, whole grain, obtains fritillary bulb particle；
(5) plus auxiliary material is placed in mixing 15-25 minutes in three-dimensional motion mixer, adjusts mouthfeel；
(6) and then using rotary pelleting machine tabletting fritillary bulb tabletting is obtained.
As preferable technical scheme：
Preferably, step（6）In, when obtained fritillary bulb tabletting is fritillary bulb pyrus nivalis tabletting, each group in fritillary bulb pyrus nivalis tabletting
Point amount be：Fritillary bulb particle 8g, microcrystalline cellulose 50g, pyrus nivalis powder 12g, menthol 0.02g, lactose 90g, magnesium stearate
0.2g, green lemon powder 5g, citric acid 0.03g, maltodextrin 35g, malic acid 0.01g.
Preferably, step（6）In, when obtained fritillary bulb tabletting is fritillary bulb kumquat tabletting, in fritillary bulb kumquat tabletting
The amount of each component is：Fritillary bulb particle 9g, kumquat powder 13g, microcrystalline cellulose 76g, lactose 60g, malt paste 30g, mango 5g, three
Chlorine sucrose 0.04g, banaina 5g, coconut powder 2g, menthol 0.02g, magnesium stearate 0.2g.
Preferably, step（6）In, when obtained fritillary bulb tabletting is fritillary bulb apple tabletting, in fritillary bulb apple tabletting
The amount of each component is：Fritillary bulb particle 16g, microcrystalline cellulose 74g, maltodextrin 30g, lactose 70g, citric acid 0.04g, apple
Powder 10g, magnesium stearate 0.4g, menthol 0.02g.
Preferably, in step (1), even particle size, the fritillary bulb that full, color is white, mealiness is sufficient are chosen.
Preferably, in step (3), the temperature of baking oven is 60 DEG C.
Preferably, in step (3), the time of oven drying is 2-3 hours.
The tablet forming technique of fritillary bulb and existing tablet forming technique are different, filtrate will merge three times in step, and be concentrated into
20g thick pastes；The dregs of a decoction are broken into be well mixed with thick paste after fine powder and make tabletting, this side using the method for mixing the dregs of a decoction and filtrate
Method is in the prior art without it can not only make full use of the active ingredient in the fritillary bulb dregs of a decoction, reach therapeutic effect, also
The taking dose of patient can be controlled, is reduced and is wasted, be cost-effective, is adapted to large-scale production.
In addition, the fritillary bulb piece mouthfeel of in the market is more single, it is few to be applicable crowd.And it is auxiliary to add menthol, apple powder etc.
Material can adjust mouthfeel, and more patients can be allowed to receive easily, can also further be played the fritillary bulb tabletting property of medicine.
Beneficial effect
1st, process choice raw material science of the invention, production technology are advanced；
2nd, spices and preservative are not added in sheeted product of the invention, keep raw material flavor in itself and nutrition, easily quilt
Absorption of human body；
3rd, sheeted product raw material sources of the invention are extensive, add process line short, product easy processing system；
4th, extracting method of the invention fully can not only come out extracts active ingredients, and tabletting is made, and patient can determine
Amount is taken, and the advantages of storage, traffic condition is less demanding be present.
Embodiment
The invention will be further elucidated with reference to specific embodiments.It should be understood that these embodiments are merely to illustrate this hair
Bright rather than limitation the scope of the present invention.In addition, it is to be understood that after the content of the invention lectured has been read, art technology
Personnel can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited
Fixed scope.
Embodiment 1
A kind of preparation method of fritillary bulb tabletting, comprises the following steps：
（1）Pretreatment：Choose even particle size, the fritillary bulb that full, color is white, mealiness is sufficient is cleaned with flowing water, then dried；
（2）Weigh：Claim to prefetch the fritillary bulb 50g after processing；
（3）Decoct：Add the water of 10 times of volumes of fritillary bulb for the first time, decoct 1h, filtering, retain filtrate and the dregs of a decoction；It is for the second time plus flat
6 times of volume of water of fritillaria, 1h is decocted, filtering, retains filtrate and the dregs of a decoction；Third time plus 5 times of water of fritillary bulb, 15min is decocted, filtered,
Retain filtrate and the dregs of a decoction；
（3）Merge concentration:It filtrate will merge three times, and be concentrated into 20g thick pastes；The dregs of a decoction are broken into after fine powder and are well mixed with thick paste,
It is placed in wet granulator and is pelletized after 20 mesh sieve net filtrations, then with oven drying, the temperature of baking oven is 60 DEG C, and baking oven is done
The dry time is 3 hours whole grains, obtains fritillary bulb particle；
（4）Add auxiliary material to be placed in three-dimensional motion mixer to mix 15 minutes, adjust mouthfeel；
（5）Then fritillary bulb tabletting is obtained using rotary pelleting machine tabletting.When obtained fritillary bulb tabletting is fritillary bulb pyrus nivalis tabletting,
The amount of each component is in fritillary bulb pyrus nivalis tabletting：Fritillary bulb particle 8g, microcrystalline cellulose 50g, pyrus nivalis powder 12g, menthol
0.02g, lactose 90g, magnesium stearate 0.2g, green lemon powder 5g, citric acid 0.03g, maltodextrin 35g, malic acid 0.01g.
Sensory evaluation：
The result obtained below for fritillary bulb pyrus nivalis tabletting progress sensory evaluation prepared by the embodiment of the present invention 1：
Index fritillary bulb pyrus nivalis tabletting
Appearance luster is evenly distributed, and profile is complete, smooth, neat in edge, and thickness is uniform
Local flavor sour-sweet is agreeable to the taste, has the taste of pyrus nivalis
Quality hardness is moderate, organizes fine and closely woven uniform
Smoother taste, no harsh feeling
Note：Subjective appreciation is 10 people group evaluation results.
Embodiment 2
A kind of preparation method of fritillary bulb tabletting, comprises the following steps：
（1）Pretreatment：Choose even particle size, the fritillary bulb that full, color is white, mealiness is sufficient is cleaned with flowing water, then dried；
（2）Weigh：Claim to prefetch the fritillary bulb 50g after processing；
（3）Decoct：Add the water of 10 times of volumes of fritillary bulb for the first time, decoct 1h, filtering, retain filtrate and the dregs of a decoction；It is for the second time plus flat
6 times of volume of water of fritillaria, 1h is decocted, filtering, retains filtrate and the dregs of a decoction；Third time plus 5 times of water of fritillary bulb, 15min is decocted, filtered,
Retain filtrate and the dregs of a decoction；
（4）Merge concentration:It filtrate will merge three times, and be concentrated into 20g thick pastes；The dregs of a decoction are broken into after fine powder and are well mixed with thick paste,
It is placed in wet granulator and is pelletized after 20 mesh sieve net filtrations, then with oven drying, the temperature of baking oven is 60 DEG C, and baking oven is done
The dry time is 2 hours whole grains, obtains fritillary bulb particle；
（5）Add auxiliary material to be placed in three-dimensional motion mixer to mix 25 minutes, adjust mouthfeel；
（6）Then fritillary bulb tabletting is obtained using rotary pelleting machine tabletting.When obtained fritillary bulb tabletting is fritillary bulb kumquat tabletting,
The amount of each component is in fritillary bulb kumquat tabletting：Fritillary bulb particle 9g, kumquat powder 13g, microcrystalline cellulose 76g, lactose 60g, wheat
Bud pastes 30g, mango 5g, Sucralose 0.04g, banaina 5g, coconut powder 2g, menthol 0.02g, magnesium stearate 0.2g.
Sensory evaluation：
The result obtained below for fritillary bulb kumquat tabletting progress sensory evaluation prepared by the embodiment of the present invention 2：
Index fritillary bulb kumquat tabletting
Appearance luster is evenly distributed, and profile is complete, smooth, neat in edge, and thickness is uniform
Local flavor sour-sweet is agreeable to the taste, has the taste of kumquat
Quality hardness is moderate, organizes fine and closely woven uniform
Smoother taste, no harsh feeling
Note：Subjective appreciation is 10 people group evaluation results.
Embodiment 3
A kind of preparation method of fritillary bulb tabletting, comprises the following steps：
（1）Pretreatment：Choose even particle size, the fritillary bulb that full, color is white, mealiness is sufficient is cleaned with flowing water, then dried；
（2）Weigh：Claim to prefetch the fritillary bulb 50g after processing；
（3）Decoct：Add the water of 10 times of volumes of fritillary bulb for the first time, decoct 1h, filtering, retain filtrate and the dregs of a decoction；It is for the second time plus flat
6 times of volume of water of fritillaria, 1h is decocted, filtering, retains filtrate and the dregs of a decoction；Third time plus 5 times of water of fritillary bulb, 15min is decocted, filtered,
Retain filtrate and the dregs of a decoction；
（4）Merge concentration:It filtrate will merge three times, and be concentrated into 20g thick pastes；The dregs of a decoction are broken into after fine powder and are well mixed with thick paste,
It is placed in wet granulator and is pelletized after 20 mesh sieve net filtrations, then with oven drying, the temperature of baking oven is 60 DEG C, and baking oven is done
The dry time is 2.5 hours whole grains, obtains fritillary bulb particle；
（5）Add auxiliary material to be placed in three-dimensional motion mixer to mix 20 minutes, adjust mouthfeel；
（6）Then fritillary bulb tabletting is obtained using rotary pelleting machine tabletting.When obtained fritillary bulb tabletting is fritillary bulb apple tabletting,
The amount of each component is in fritillary bulb apple tabletting：Fritillary bulb particle 16g, microcrystalline cellulose 74g, maltodextrin 30g, lactose 70g,
Citric acid 0.04g, apple powder 10g, magnesium stearate 0.4g, menthol 0.02g.
Sensory evaluation：
The result obtained below for fritillary bulb apple tabletting progress sensory evaluation prepared by the embodiment of the present invention 3：
Index fritillary bulb apple tabletting
Appearance luster is evenly distributed, and profile is complete, smooth, neat in edge, and thickness is uniform
Local flavor sour-sweet is agreeable to the taste, has the taste of apple
Quality hardness is moderate, organizes fine and closely woven uniform
Smoother taste, no harsh feeling
Note：Subjective appreciation is 10 people group evaluation results.
The tablet forming technique and existing tablet forming technique of the fritillary bulb of the present invention are different, filtrate will be closed three times in step
And it is concentrated into 20g thick pastes；The dregs of a decoction are broken into be well mixed with thick paste after fine powder and made using the method for mixing the dregs of a decoction and filtrate
Tabletting, the method are in the prior art without it can not only make full use of the active ingredient in the fritillary bulb dregs of a decoction, reach and control
Therapeutic effect, the taking dose of patient can also be controlled, reduce and waste, be cost-effective, be adapted to large-scale production.
Claims (7)
1. a kind of preparation method of fritillary bulb tabletting, it is characterized in that, comprise the following steps：
(1) pretreatment：Fritillary bulb is cleaned with flowing water, then dried；
(2) weigh：Claim to prefetch the fritillary bulb 50g after processing；
Decoct：Add the water of 10 times of volumes of fritillary bulb for the first time, decoct 1h, filtering, retain filtrate and the dregs of a decoction；Second plus fritillary bulb
6 times of volume of water, 1h is decocted, filtering, retains filtrate and the dregs of a decoction；Third time plus 5 times of water of fritillary bulb, 15min is decocted, filtered, retained
Filtrate and the dregs of a decoction；
(3) concentration is merged:It filtrate will merge three times, and be concentrated into 20g thick pastes；The dregs of a decoction are broken into after fine powder and are well mixed with thick paste,
Pelletized after 20 mesh sieve net filtrations, then with oven drying, whole grain, obtain fritillary bulb particle；
(4) plus mouthfeel is adjusted in auxiliary material mixing；
(5) tabletting obtains fritillary bulb tabletting.
2. a kind of preparation method of fritillary bulb tabletting according to claim 1, it is characterized in that, step（6）In, it is obtained flat
When fritillaria tabletting is fritillary bulb pyrus nivalis tabletting, the amount of each component is in fritillary bulb pyrus nivalis tabletting：Fritillary bulb particle 8g, microcrystalline cellulose
Plain 50g, pyrus nivalis powder 12g, menthol 0.02g, lactose 90g, magnesium stearate 0.2g, green lemon powder 5g, citric acid 0.03g, malt
Dextrin 35g, malic acid 0.01g.
3. a kind of preparation method of fritillary bulb tabletting according to claim 1, it is characterized in that, step（6）In, it is obtained flat
When fritillaria tabletting is fritillary bulb kumquat tabletting, the amount of each component is in fritillary bulb kumquat tabletting：Fritillary bulb particle 9g, kumquat powder
13g, microcrystalline cellulose 76g, lactose 60g, malt paste 30g, mango 5g, Sucralose 0.04g, banaina 5g, coconut powder 2g are thin
Lotus brain 0.02g, magnesium stearate 0.2g.
4. a kind of preparation method of fritillary bulb tabletting according to claim 1, it is characterized in that, step（6）In, it is obtained flat
When fritillaria tabletting is fritillary bulb apple tabletting, the amount of each component is in fritillary bulb apple tabletting：Fritillary bulb particle 16g, crystallite are fine
Tie up plain 74g, maltodextrin 30g, lactose 70g, citric acid 0.04g, apple powder 10g, magnesium stearate 0.4g, menthol 0.02g.
5. a kind of preparation method of fritillary bulb tabletting according to claim 1, it is characterized in that, in step (1), choose particle
Fritillary bulb uniform in size, full, color is white, mealiness is sufficient.
6. a kind of preparation method of fritillary bulb tabletting according to claim 1, it is characterized in that, in step (3), the temperature of baking oven
Spend for 60 DEG C.
7. a kind of preparation method of fritillary bulb tabletting according to claim 6, it is characterized in that, in step (3), oven drying
Time be 2-3 hours.
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