CN107663238A - 筛选方法及其应用 - Google Patents

筛选方法及其应用 Download PDF

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Publication number
CN107663238A
CN107663238A CN201710970655.5A CN201710970655A CN107663238A CN 107663238 A CN107663238 A CN 107663238A CN 201710970655 A CN201710970655 A CN 201710970655A CN 107663238 A CN107663238 A CN 107663238A
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CN
China
Prior art keywords
ligand
mrow
ligands
msub
construct
Prior art date
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Pending
Application number
CN201710970655.5A
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English (en)
Chinese (zh)
Inventor
比约恩·弗伦多斯
詹妮·马特森
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Bioinvent International AB
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Bioinvent International AB
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Publication of CN107663238A publication Critical patent/CN107663238A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Oncology (AREA)
CN201710970655.5A 2011-09-22 2012-09-20 筛选方法及其应用 Pending CN107663238A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1116364.9 2011-09-22
GBGB1116364.9A GB201116364D0 (en) 2011-09-22 2011-09-22 Screening methods and uses thereof
CN201280046053.6A CN103827302A (zh) 2011-09-22 2012-09-20 筛选方法及其应用

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280046053.6A Division CN103827302A (zh) 2011-09-22 2012-09-20 筛选方法及其应用

Publications (1)

Publication Number Publication Date
CN107663238A true CN107663238A (zh) 2018-02-06

Family

ID=44937671

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201710970655.5A Pending CN107663238A (zh) 2011-09-22 2012-09-20 筛选方法及其应用
CN201280046053.6A Pending CN103827302A (zh) 2011-09-22 2012-09-20 筛选方法及其应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280046053.6A Pending CN103827302A (zh) 2011-09-22 2012-09-20 筛选方法及其应用

Country Status (17)

Country Link
US (1) US10191049B2 (https=)
EP (1) EP2758532B1 (https=)
JP (2) JP6370220B2 (https=)
KR (1) KR102024125B1 (https=)
CN (2) CN107663238A (https=)
AU (1) AU2012311542B2 (https=)
CA (1) CA2848932C (https=)
DK (1) DK2758532T3 (https=)
ES (1) ES2690783T3 (https=)
GB (1) GB201116364D0 (https=)
HU (1) HUE040567T2 (https=)
IN (1) IN2014DN01795A (https=)
PL (1) PL2758532T3 (https=)
PT (1) PT2758532T (https=)
RU (1) RU2622089C2 (https=)
SI (1) SI2758532T1 (https=)
WO (1) WO2013041643A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2392723B (en) 2002-09-04 2005-01-12 Bioinvent Int Ab Screening methods
WO2011140241A2 (en) 2010-05-04 2011-11-10 The General Hospital Corporation Methods and compositions for preserving tissues and organs
GB201116364D0 (en) 2011-09-22 2011-11-02 Bioinvent Int Ab Screening methods and uses thereof
JP6465407B2 (ja) * 2013-11-22 2019-02-06 株式会社Ｍｏｌｃｕｒｅ 標的分子に結合するポリペプチドの決定方法及び決定システム
EP3698628A1 (en) 2014-08-07 2020-08-26 The General Hospital Corporation Stabilization of whole blood samples
CN109651506B (zh) * 2017-10-11 2021-12-07 上海交通大学 一种快速获得抗原特异性抗体的方法
CN119384696A (zh) * 2022-06-13 2025-01-28 生物发明国际公司 分离反配体的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004023140A1 (en) * 2002-09-04 2004-03-18 Bioinvent International Ab Method for screening anti-ligand libraries for identifying anti-ligands specific for differentially and infrequently expressed ligands

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US5366862A (en) 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
AU8081491A (en) 1990-06-01 1991-12-31 Cetus Corporation Compositions and methods for identifying biologically active molecules
AU1378495A (en) 1993-12-27 1995-07-17 Hamilton Civic Hospitals Research Development, Inc. Methods and compositions for inhibiting thrombogenesis
US6794128B2 (en) 1998-04-24 2004-09-21 The Regents Of The University Of California Methods of selecting internalizing antibodies
WO2000052054A2 (en) 1999-03-01 2000-09-08 Genentech, Inc. Antibodies for cancer therapy and diagnosis
US7135287B1 (en) 1999-10-02 2006-11-14 Biosite, Inc. Human antibodies
AU2002220236A1 (en) 2000-11-09 2002-05-21 Bionova Pharmaceutials, Inc. A method for identifying the proteome of cells using an antibody library microarray
CN100575489C (zh) 2003-05-14 2009-12-30 多曼蒂斯有限公司 从多肽全能文库恢复可逆可解折叠多肽的方法
US20090005257A1 (en) 2003-05-14 2009-01-01 Jespers Laurent S Process for Recovering Polypeptides that Unfold Reversibly from a Polypeptide Repertoire
GB0422431D0 (en) * 2004-10-08 2004-11-10 Affitech As Method
EP2254909A4 (en) 2007-12-21 2012-05-02 Ca Nat Research Council NON-AGGREGATING HUMANS VH DOMAINS
GB201116364D0 (en) 2011-09-22 2011-11-02 Bioinvent Int Ab Screening methods and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004023140A1 (en) * 2002-09-04 2004-03-18 Bioinvent International Ab Method for screening anti-ligand libraries for identifying anti-ligands specific for differentially and infrequently expressed ligands

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GLANVILLE J等: "Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire", 《PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES》 *
REDDY S T等: "Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells", 《NATURE BIOTECHNOLOGY》 *

Also Published As

Publication number Publication date
EP2758532A1 (en) 2014-07-30
KR102024125B1 (ko) 2019-09-23
RU2622089C2 (ru) 2017-06-09
JP2018154627A (ja) 2018-10-04
HK1200486A1 (en) 2015-08-07
KR20140080504A (ko) 2014-06-30
PT2758532T (pt) 2018-11-07
PL2758532T3 (pl) 2018-12-31
EP2758532B1 (en) 2018-07-11
ES2690783T3 (es) 2018-11-22
HUE040567T2 (hu) 2019-03-28
US20140227249A1 (en) 2014-08-14
CA2848932A1 (en) 2013-03-28
AU2012311542B2 (en) 2017-09-21
DK2758532T3 (en) 2018-10-22
WO2013041643A1 (en) 2013-03-28
US10191049B2 (en) 2019-01-29
AU2012311542A1 (en) 2014-03-20
JP2015501289A (ja) 2015-01-15
GB201116364D0 (en) 2011-11-02
IN2014DN01795A (https=) 2015-05-15
CA2848932C (en) 2020-12-29
SI2758532T1 (sl) 2018-12-31
RU2014115956A (ru) 2015-10-27
CN103827302A (zh) 2014-05-28
JP6370220B2 (ja) 2018-08-08

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