CN107663238A - 筛选方法及其应用 - Google Patents

筛选方法及其应用 Download PDF

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Publication number
CN107663238A
CN107663238A CN201710970655.5A CN201710970655A CN107663238A CN 107663238 A CN107663238 A CN 107663238A CN 201710970655 A CN201710970655 A CN 201710970655A CN 107663238 A CN107663238 A CN 107663238A
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CN
China
Prior art keywords
ligand
mrow
ligands
msub
construct
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Pending
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CN201710970655.5A
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English (en)
Chinese (zh)
Inventor
比约恩·弗伦多斯
詹妮·马特森
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Bioinvent International AB
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Bioinvent International AB
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Publication of CN107663238A publication Critical patent/CN107663238A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Oncology (AREA)
CN201710970655.5A 2011-09-22 2012-09-20 筛选方法及其应用 Pending CN107663238A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1116364.9 2011-09-22
GBGB1116364.9A GB201116364D0 (en) 2011-09-22 2011-09-22 Screening methods and uses thereof
CN201280046053.6A CN103827302A (zh) 2011-09-22 2012-09-20 筛选方法及其应用

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280046053.6A Division CN103827302A (zh) 2011-09-22 2012-09-20 筛选方法及其应用

Publications (1)

Publication Number Publication Date
CN107663238A true CN107663238A (zh) 2018-02-06

Family

ID=44937671

Family Applications (2)

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CN201710970655.5A Pending CN107663238A (zh) 2011-09-22 2012-09-20 筛选方法及其应用
CN201280046053.6A Pending CN103827302A (zh) 2011-09-22 2012-09-20 筛选方法及其应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280046053.6A Pending CN103827302A (zh) 2011-09-22 2012-09-20 筛选方法及其应用

Country Status (17)

Country Link
US (1) US10191049B2 (enExample)
EP (1) EP2758532B1 (enExample)
JP (2) JP6370220B2 (enExample)
KR (1) KR102024125B1 (enExample)
CN (2) CN107663238A (enExample)
AU (1) AU2012311542B2 (enExample)
CA (1) CA2848932C (enExample)
DK (1) DK2758532T3 (enExample)
ES (1) ES2690783T3 (enExample)
GB (1) GB201116364D0 (enExample)
HU (1) HUE040567T2 (enExample)
IN (1) IN2014DN01795A (enExample)
PL (1) PL2758532T3 (enExample)
PT (1) PT2758532T (enExample)
RU (1) RU2622089C2 (enExample)
SI (1) SI2758532T1 (enExample)
WO (1) WO2013041643A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2392723B (en) 2002-09-04 2005-01-12 Bioinvent Int Ab Screening methods
US10575515B2 (en) 2010-05-04 2020-03-03 The General Hospital Corporation Methods and compositions for preserving tissues and organs
GB201116364D0 (en) 2011-09-22 2011-11-02 Bioinvent Int Ab Screening methods and uses thereof
WO2015076355A1 (ja) * 2013-11-22 2015-05-28 株式会社Ｍｏｌｃｕｒｅ 標的分子に結合するポリペプチドの決定方法及び決定システム
EP3698628A1 (en) 2014-08-07 2020-08-26 The General Hospital Corporation Stabilization of whole blood samples
CN109651506B (zh) * 2017-10-11 2021-12-07 上海交通大学 一种快速获得抗原特异性抗体的方法
WO2023242125A1 (en) 2022-06-13 2023-12-21 Bioinvent International Ab Methods of isolating anti-ligands

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004023140A1 (en) * 2002-09-04 2004-03-18 Bioinvent International Ab Method for screening anti-ligand libraries for identifying anti-ligands specific for differentially and infrequently expressed ligands

Family Cites Families (12)

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US5366862A (en) 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
DK0600866T3 (da) 1990-06-01 1998-03-09 Chiron Corp Præparater og fremgangsmåder til identifikation af biologisk aktive molekyler
CA2180140A1 (en) 1993-12-27 1995-07-06 Jeffrey I. Weitz Methods and compositions for inhibiting thrombogenesis
US6794128B2 (en) 1998-04-24 2004-09-21 The Regents Of The University Of California Methods of selecting internalizing antibodies
IL144559A0 (en) 1999-03-01 2002-05-23 Genentech Inc Antibodies for cancer therapy and diagnosis
US7135287B1 (en) 1999-10-02 2006-11-14 Biosite, Inc. Human antibodies
US20050130320A1 (en) 2000-11-09 2005-06-16 George Shaji. T. Method for identifying the proteome of cells using an antibody library microarray
US20090005257A1 (en) * 2003-05-14 2009-01-01 Jespers Laurent S Process for Recovering Polypeptides that Unfold Reversibly from a Polypeptide Repertoire
CN101333243A (zh) 2003-05-14 2008-12-31 多曼蒂斯有限公司 从多肽全能文库恢复可逆可解折叠多肽的方法
GB0422431D0 (en) * 2004-10-08 2004-11-10 Affitech As Method
US20110052565A1 (en) 2007-12-21 2011-03-03 National Research Council Of Canada Non-aggregating human vh domains
GB201116364D0 (en) 2011-09-22 2011-11-02 Bioinvent Int Ab Screening methods and uses thereof

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2004023140A1 (en) * 2002-09-04 2004-03-18 Bioinvent International Ab Method for screening anti-ligand libraries for identifying anti-ligands specific for differentially and infrequently expressed ligands

Non-Patent Citations (2)

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GLANVILLE J等: "Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire", 《PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES》 *
REDDY S T等: "Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells", 《NATURE BIOTECHNOLOGY》 *

Also Published As

Publication number Publication date
KR102024125B1 (ko) 2019-09-23
HUE040567T2 (hu) 2019-03-28
PT2758532T (pt) 2018-11-07
CN103827302A (zh) 2014-05-28
US10191049B2 (en) 2019-01-29
EP2758532A1 (en) 2014-07-30
RU2014115956A (ru) 2015-10-27
IN2014DN01795A (enExample) 2015-05-15
RU2622089C2 (ru) 2017-06-09
AU2012311542B2 (en) 2017-09-21
GB201116364D0 (en) 2011-11-02
AU2012311542A1 (en) 2014-03-20
CA2848932C (en) 2020-12-29
HK1200486A1 (en) 2015-08-07
EP2758532B1 (en) 2018-07-11
JP6370220B2 (ja) 2018-08-08
SI2758532T1 (sl) 2018-12-31
KR20140080504A (ko) 2014-06-30
JP2015501289A (ja) 2015-01-15
PL2758532T3 (pl) 2018-12-31
DK2758532T3 (en) 2018-10-22
JP2018154627A (ja) 2018-10-04
US20140227249A1 (en) 2014-08-14
WO2013041643A1 (en) 2013-03-28
ES2690783T3 (es) 2018-11-22
CA2848932A1 (en) 2013-03-28

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