CN107648596A - A kind of fruit stem cell drugs and preparation method thereof - Google Patents
A kind of fruit stem cell drugs and preparation method thereof Download PDFInfo
- Publication number
- CN107648596A CN107648596A CN201711010971.4A CN201711010971A CN107648596A CN 107648596 A CN107648596 A CN 107648596A CN 201711010971 A CN201711010971 A CN 201711010971A CN 107648596 A CN107648596 A CN 107648596A
- Authority
- CN
- China
- Prior art keywords
- fruit
- dendrobium candidum
- extract
- stem cell
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
- C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
- C12Y115/01001—Superoxide dismutase (1.15.1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of fruit stem cell drugs, including following raw material：Fruit extract, TSPG, dendrobium candidum, Moringa extract, lycium ruthenicum extract, Glucophage, Xi Gelieting.Fruit stem cell drugs provided by the invention have promote the production of body fluid to quench thirst, nourishing and suppressing Yang, kidney-supplementing liver-boosting, strengthening spleen and nourishing stomach, antiviral, Green Tea Extract, lipid-loweringing, decompression, hypoglycemic, drop urine, depressor muscle acid anhydride, anticancer the effect of；Spices and preservative are not added in product, the nutrition of raw material in itself is kept, is easily absorbed by the body；It is simple for production and sweet mouthfeel is tasty；Present invention increase fruit stem cell, can improve Metformin hydrochloride and secondary damages and side effect of the phosphoric acid Xi Gelieting to human body.
Description
Technical field
The present invention relates to a kind of medicine, specifically a kind of fruit stem cell drugs and preparation method thereof.
Background technology
There is following disease with the change of rhythm of life, many moderns with the improvement of living standards：High fat of blood, high blood
Pressure, fatty liver, hyperglycaemia, high creatinine, high lithemia, high enzyme system, high immune system disorder, high cancer tendency, referred to as " nine is high ".
In the ten big causes of death of Chinese, the death rate related to metabolic disease is just up to 35.7%, the dead people related to " nine is high "
It is also to rise year by year that number, which accounts for total death toll ratio,.Research for " nine is high " treatment is very urgent.High controlled for nine at present
Treatment relies primarily on Western medicine or Chinese medicine to treat, and because Western medicine side effect is big, many side effects usually occurs, and easily occur simultaneously
Send out disease；Metformin hydrochloride tablet can reduce the incidence of many cancers, also have preventive effect to heart disease and senile dementia；Salt
Sour diformin tablet is effective for treating diabetes, but it has stool abnormity, hypoglycemia, myalgia, giddy, dizziness, chest not
The side effects such as suitable, shiver with cold, palpitaition, weight loss.Phosphoric acid Xi Gelieting is insulin sensitizer, and it can cause the serious kidney function of patient
Can be impaired.And Chinese medicine is poor due to mouthfeel, it is more difficult to adhere to, be unable to reach preferable therapeutic effect.Therefore, the present invention provides one and helped
Fruit stem cell drugs and preparation method thereof.
The content of the invention
It is an object of the invention to provide a kind of fruit stem cell drugs and preparation method thereof, to solve above-mentioned background technology
The problem of middle proposition.
To achieve the above object, the present invention provides following technical scheme：
A kind of fruit stem cell drugs, including following raw material：Fruit extract, TSPG, dendrobium candidum, Moringa extraction
Thing, lycium ruthenicum extract, Glucophage, Xi Gelieting.
As the further scheme of the present invention：Include the raw material of following parts by weight：15~25 parts of fruit extract, ginseng
10~30 parts of Total saponin, 10~30 parts of dendrobium candidum, 30~60 parts of Moringa extract, 5~15 parts of lycium ruthenicum extract, Glucophage
5~25 parts, 5~25 parts of Xi Gelieting.
As the further scheme of the present invention：The fruit extract includes the component of following parts by weight：Ellagic acid 0.1
~1 part, 1~2 part of anthocyanidin, 0.1~1 part of superoxide dismutase, 0.1~1 part of B B-complex, 0.5~2 part of salicylic acid,
0.1~1 part of fruit flavones, 0.2~2 part of fruit cellulose.
As the further scheme of the present invention：Also include calcium and magnesium.
As the further scheme of the present invention：Include the raw material of following parts by weight：0.1~1 part of calcium, 0.1~1 part of magnesium.
As the further scheme of the present invention：Active ingredient in the dendrobium candidum is：Dendrobium candidum element A, iron sheet stone
Dry measure used in former times element B, dendrobium candidum element C, dendrobium candidum element D, dendrobium candidum element E, dendrobium candidum element F, dendrobium candidum element G, dendrobium candidum element
H, dendrobium candidum element I, dendrobium candidum element J, dendrobium candidum element K, dendrobium candidum element L, dendrobium candidum element M, dendrobium candidum element N, iron
Skin stem of noble dendrobium element O, dendrobium candidum element P and dendrobium candidum element Q.
As the further scheme of the present invention：The fruit extract is from one kind in card nurse fruit, A Sayi fruits and raspberry
Or a variety of middle extractions；The TSPG extracts from American Ginseng.
As the further scheme of the present invention：The extraction of the fruit flavones, comprises the following steps：A. by card nurse fruit, Ah
Dry, be stored in standby at drying immediately after one or more harvestings in Say fruit and raspberry；B. by card nurse fruit, A Sayi fruits
Crushed with the one or more in raspberry, then add in the sodium hydroxide solution that mass fraction is 0.4~0.6%, be heated to
70~90 DEG C, it is incubated 1 hour；Extraction 3 times, preceding 1~2h of time twice, third time extraction time is 30min, will extraction after extraction
Liquid merges, and then filters；C. the extract solution after filtering is concentrated, when concentration reaches 40~50%, 3 is added into concentrate
95% second ferment of times volume, makes solution alcohol content reach 70%；Refrigeration, makes most of starch, pectin, protein, mucilaginous substance
Precipitation, is refiltered；D. the alcoholic solution after filtering is distilled, reclaims ethanol, the condensed cream of gained is fruit flavones.
A kind of preparation method of fruit stem cell drugs, comprises the following steps：（1）By fruit extract, TSPG,
Dendrobium candidum, Moringa extract, lycium ruthenicum extract, Glucophage and Xi Gelieting mixing, it is pre- at a temperature of being placed in -50~-30 DEG C
Freeze 2 hours；- 35~-20 DEG C are then heated to, carries out the drying sublimation process of lyophilized medicine, absolute pressure is 4~7Pa, is dried
Temperature 60 C, total 18 hours drying times；Then >=room temperature is gradually heating to, adds calcium and magnesium, is well mixed；（2）Tabletting, pressure
Envionmental humidity during sheetmolding is controlled below 60%；（3）It is filling, sterilizing, produce.
Compared with prior art, the beneficial effects of the invention are as follows：
Fruit stem cell drugs provided by the invention have promote the production of body fluid to quench thirst, nourishing and suppressing Yang, antiviral, Green Tea Extract, blood lipid-reducing blood sugar-decreasing
The effect of；Spices and preservative are not added in product, the nutrition of raw material in itself is kept, is easily absorbed by the body；And mouthfeel
Sweet and sour taste, it is simple for production, it is antiviral, Green Tea Extract lipid-loweringing workable for Chinese 2.97 hundred million cardiovascular and cerebrovasculars, diabetic
The active drug of hypoglycemic；And present invention increase fruit stem cell, Metformin hydrochloride can be improved with phosphoric acid Xi Gelieting to human body
Secondary damage and side effect；In addition, the present invention is high for nine（High fat of blood, hypertension, fatty liver, hyperglycaemia, high creatinine, height
Uric acid, high enzyme system, high immune system disorder, high cancer tendency）There is the effect of certain.
Embodiment
The technical scheme of this patent is described in more detail with reference to embodiment.
Embodiment 1
A kind of fruit stem cell drugs, include the raw material of following parts by weight：15 parts of fruit extract, 10 parts of TSPG,
10 parts of dendrobium candidum, 30 parts of Moringa extract, 5 parts of lycium ruthenicum extract, 5 parts of Glucophage, 5 parts of Xi Gelieting, 0.1 part of calcium, magnesium
0.1 part.The fruit extract includes the component of following parts by weight：0.1 part of ellagic acid, 1 part of anthocyanidin, superoxide dismutase
0.1 part of enzyme, 0.1 part of B B-complex, 0.5 part of salicylic acid, 0.1 part of fruit flavones, 0.2 part of fruit cellulose.The iron sheet stone
Active ingredient in dry measure used in former times is：Dendrobium candidum element A, dendrobium candidum element B, dendrobium candidum element C, dendrobium candidum element D, dendrobium candidum element E,
Dendrobium candidum element F, dendrobium candidum element G, dendrobium candidum element H, dendrobium candidum element I, dendrobium candidum element J, dendrobium candidum element K, iron sheet
Stem of noble dendrobium element L, dendrobium candidum element M, dendrobium candidum element N, dendrobium candidum element O, dendrobium candidum element P and dendrobium candidum element Q.The fruit
Extract extracts from card nurse fruit.The TSPG extracts from American Ginseng.
The extraction of fruit flavones, comprises the following steps：A. dry, be stored in standby at drying immediately after card nurse fruit is plucked
With；B. it is card nurse fruit powder is broken, then add in the sodium hydroxide solution that mass fraction is 0.4%, be heated to 70 DEG C, insulation 1 is small
When, flavone compound is fully dissolved into water；Extraction 3 times, preceding time 1h twice, third time extraction time is 30min, is carried
Extract solution is merged after taking, then filtered；C. the extract solution after filtering is concentrated, when concentration reaches 40%, to concentrate
The middle 95% second ferment for adding 3 times of volumes, makes solution alcohol content reach 70% or so；Refrigeration, makes most of starch, pectin, egg
White matter, mucilaginous substance etc. precipitate, and refilter；D. the alcoholic solution after filtering is distilled, reclaims ethanol, the condensed cream of gained is fruit
Flavones.
Points for attention：Solubility of the materials such as flavonoids in acid or weakly acidic solution is typically small, easily in filtering
Remove, the pH value of solution should be adjusted to alkalescent；It also can first be extracted with 75% alcohol reflux in production, then filtered while hot, with
Exempt from flavones to separate out to the cold；Distillating filtering liquid, reclaim ethanol, can also will distillation residue with hot water dissolving, then filter, to remove
Wax lipid impurities, the flavones aqueous solution of filtering are extracted repeatedly with ethyl acetate again, to remove water-soluble polysaccharide, recycling solvent,
Get product.
A kind of preparation method of fruit stem cell drugs, comprises the following steps：（1）By fruit extract, TSPG,
Dendrobium candidum, Moringa extract, lycium ruthenicum extract, Glucophage and Xi Gelieting mixing, pre-freeze 2 is small at a temperature of being placed in -50 DEG C
When；- 35 DEG C are then heated to, the drying sublimation process of lyophilized medicine is carried out, absolute pressure 4Pa, 60 DEG C of drying temperature, always does
The dry 18 hours time；Then 40 DEG C are gradually heating to（Higher than 25 DEG C of room temperature）, calcium and magnesium are added, is well mixed；（2）Tabletting, pressure
Envionmental humidity during sheetmolding is controlled below 60%；（3）It is filling, sterilizing, produce.
Embodiment 2
A kind of fruit stem cell drugs, include the raw material of following parts by weight：25 parts of fruit extract, 30 parts of TSPG,
30 parts of dendrobium candidum, 60 parts of Moringa extract, 15 parts of lycium ruthenicum extract, 25 parts of Glucophage, 25 parts of Xi Gelieting, 1 part of calcium, magnesium
1 part.The fruit extract includes the component of following parts by weight：1 part of ellagic acid, 2 parts of anthocyanidin, superoxide dismutase 1
Part, 1 part of B B-complex, 2 parts of salicylic acid, 1 part of fruit flavones, 2 parts of fruit cellulose.Active ingredient in the dendrobium candidum
For：Dendrobium candidum element A, dendrobium candidum element B, dendrobium candidum element C, dendrobium candidum element D, dendrobium candidum element E, dendrobium candidum element F, iron
Skin stem of noble dendrobium element G, dendrobium candidum element H, dendrobium candidum element I, dendrobium candidum element J, dendrobium candidum element K, dendrobium candidum element L, iron sheet stone
Dry measure used in former times element M, dendrobium candidum element N, dendrobium candidum element O, dendrobium candidum element P and dendrobium candidum element Q.The fruit extract is from card nurse fruit
Extracted with A Sayi fruits.The TSPG extracts from American Ginseng.
The extraction of the fruit flavones, comprises the following steps：A. it will immediately dry, store after card nurse fruit and the harvesting of A Sayi fruits
It is stored in standby at drying；B. it is card nurse fruit and A Sayi fruit powders is broken, then add the sodium hydroxide solution that mass fraction is 0.6%
In, 90 DEG C are heated to, 1 hour is incubated, flavone compound is fully dissolved into water；Extraction 3 times, preceding time 2h twice, the
Extraction time is 30min three times, merges extract solution after extraction, then filters；C. the extract solution after filtering is concentrated, it is dense
When degree reaches 50%, 95% second ferment of 3 times of volumes is added into concentrate, solution alcohol content is reached 70% or so；Refrigeration,
Most of starch, pectin, protein, mucilaginous substance etc. are precipitated, is refiltered；D. the alcoholic solution after filtering is distilled, reclaims ethanol,
The condensed cream of gained is fruit flavones.
A kind of preparation method of fruit stem cell drugs, comprises the following steps：（1）By fruit extract, TSPG,
Dendrobium candidum, Moringa extract, lycium ruthenicum extract, Glucophage and Xi Gelieting mixing, pre-freeze 2 is small at a temperature of being placed in -30 DEG C
When；- 20 DEG C are then heated to, the drying sublimation process of lyophilized medicine is carried out, absolute pressure 7Pa, 60 DEG C of drying temperature, always does
The dry 18 hours time；Then 25 DEG C of room temperature is gradually heating to, adds calcium and magnesium, is well mixed；（2）Tabletting, during compression molding
Envionmental humidity is controlled below 60%；（3）It is filling, sterilizing, produce.
Embodiment 3
A kind of fruit stem cell drugs, include the raw material of following parts by weight：20 parts of fruit extract, 18 parts of TSPG,
22 parts of dendrobium candidum, 55 parts of Moringa extract, 10 parts of lycium ruthenicum extract, 18 parts of Glucophage, 20 parts of Xi Gelieting, 0.5 part of calcium,
0.5 part of magnesium.The fruit extract includes the component of following parts by weight：0.5 part of ellagic acid, 1.2 parts of anthocyanidin, superoxides
0.5 part of mutase, 0.2 part of B B-complex, 0.6 part of salicylic acid, 0.3 part of fruit flavones, 1 part of fruit cellulose.The iron sheet
Active ingredient in the stem of noble dendrobium is：Dendrobium candidum element A, dendrobium candidum element B, dendrobium candidum element C, dendrobium candidum element D, dendrobium candidum element
E, dendrobium candidum element F, dendrobium candidum element G, dendrobium candidum element H, dendrobium candidum element I, dendrobium candidum element J, dendrobium candidum element K, iron
Skin stem of noble dendrobium element L, dendrobium candidum element M, dendrobium candidum element N, dendrobium candidum element O, dendrobium candidum element P and dendrobium candidum element Q.The water
Berry extract extracts from card nurse fruit, A Sayi fruits and raspberry.The TSPG extracts from ginseng extract.
The extraction of the fruit flavones, comprises the following steps：A. shone immediately after plucking card nurse fruit, A Sayi fruits and raspberry
It is dry, it is stored in standby at drying；B. card nurse fruit, A Sayi fruits and raspberry are crushed, then adds the hydrogen that mass fraction is 0.5%
In sodium hydroxide solution, 80 DEG C are heated to, 1 hour is incubated, flavone compound is fully dissolved into water；Extraction 3 times, it is preceding twice
Time 1.6h, third time extraction time are 30min, merge extract solution after extraction, then filter；C. by the extract solution after filtering
Concentrated, when concentration reaches 45%, 95% second ferment of 3 times of volumes is added into concentrate, reaches solution alcohol content
70% or so；Refrigeration, most of starch, pectin, protein, mucilaginous substance etc. are precipitated, is refiltered；D. by the alcoholic solution after filtering
Distillation, ethanol is reclaimed, the condensed cream of gained is fruit flavones.
A kind of preparation method of fruit stem cell drugs, comprises the following steps：（1）By fruit extract, TSPG,
Dendrobium candidum, Moringa extract, lycium ruthenicum extract, Glucophage and Xi Gelieting mixing, pre-freeze 2 is small at a temperature of being placed in -40 DEG C
When；- 25 DEG C are then heated to, the drying sublimation process of lyophilized medicine is carried out, absolute pressure 5Pa, 60 DEG C of drying temperature, always does
The dry 18 hours time；Then >=room temperature is gradually heating to, adds calcium and magnesium, is well mixed；（2）Tabletting, ring during compression molding
Border relative humidity control is below 60%；（3）It is filling, sterilizing, produce.
The theoretical foundation of the present invention：
First, lycium ruthenicum, it is sweet, mild-natured, rich in protein, fat, carbohydrate, free amino acid, organic acid, mineral matter, micro member
The various nutritional ingredients such as element, alkaloid, vitamin C, B1, B2；Especially contain with remove free radical, anti-oxidation function it is natural
Anthocyanin element, especially OPC（OPC）More than blueberry（Black fruit fructus lycii 3690mg/100g containing OPC；Blueberry containing OPC330~
3380 mg/100g）, wild lycium ruthenicum is to find the very high wild fruit of OPC contents so far, and effective day
Right antioxidant, its effect are 20 times of Vc, 50 times of VE, tonic effect, and liver protection hypoglycemic is powerful；In lycium ruthenicum extract
Active ingredient includes OPC；
2nd, TSPG is the active ingredient in ginseng extract in the present invention, has following characteristic：Dissolubility：In water
Dissolving, is soluble in methanol or ethanol；Shape of product：Canescence is to grey powder；Product efficacy：Anti-aging, yang-tonifying enriching yin；Mainly
Composition：Ginseng extract mainly contains a variety of Saponins, mainly have Rb1, Rb2, Rd, Rc, Re, Ro, Re, Rf, Rg1,
Rg2, Rg3, Rh1, Rh2 etc., also containing a small amount of cupreol, flavonoids Kaempferol, trifolin, panasenoside and sweet-scented osmanthus
The plain glycoside of grass, panaxoside total content is typically between 80-90%.Clinical practice：The disease 1. vigour is collapsed.The product can be mended greatly
Vigour, veins takes off admittedly, to save danger emergency treatment of collapse key medicine.Suitable for because of profuse sweating, greatly rush down, lose blood greatly or serious disease, prolonged illness caused by vigour fictitious pole
It is intended to take off, shortness of breath and tired spirit, the danger disease again of feeble and impalpable pulse.It is alone effective, such as Du Shen Tang（《Jing Yue's complete work》）.If the deficiency of vital energy is intended to de- simultaneous see
Sweating, cold limbs person, should with the monkshood of recuperating depleted yang with using, with invigorating qi for relieving desertion and recuperating depleted yang, often with Moringa seed extract,
Iron sheet rice dry measure used in former times extract compatibility, with boosting qi and nourishing yin Jiangtang Bushen.2. the lung spleen heart kidney qi chronic diseases marked by deficiency of vital energy.The product are tonifying lung key medicine, can be improved
Lose heart syndrome characterized by dyspnea, lazy speech sound is micro- to wait decline of lung-QI symptom.Control lung qi cough and asthma, abundant expectoration person.Using：1st, applied to medicines and health protection industry,
The health food of antifatigue, anti-aging and brain tonic can be configured to；2nd, applied to cosmetics industry, can be configured to dispel
Spot, reduce wrinkle, activating skin cells, the cosmetics for strengthening skin elasticity；3rd, food additives can also be used as.
3rd, ellagic acid high content then can killing cancer cell；
4th, salicylic acid, diaphoretic can be used as, be treatment flu, influenza, the good drop medicine of a warm nature of sphagitis.It can also play certain
Regulation blood fat, cardioprotection, prevent and improve hypertension, the effect of the brittle rupture of vascular wall atherosis, the cerebrovascular；
5th, superoxide dismutase（SOD）It is best body street cleaner, harmful free radicals in human body can be removed, can be effective
Ground prevents damage of the free radical to brain, and improves the blood and oxygen supply of brain, so as to have the function that brain tonic and intelligence development；
6th, anthocyanidin：Oxygen radical present in blood is removed, helps body to prevent the generation of free radical, strengthens vascular wall
Integrality.Prevent the degradation of clostridiopetidase A and elastoser to connective tissue.Thus be advantageous to keep the elasticity of skin, hair
The effect of waving anti aging effect.The microcirculation of eye ground capillary and four limbs tip capillary can be strengthened.Pass through dimension
Hold the health of blood vessel and improve microcirculation, each organ and tissue is obtained more sufficient nutrition supply.
7th, certain kind of berries class fruit ketone：Fat combustion can be promoted, certain kind of berries ketone can directly act on adipocyte, stimulate human body adiponectin
（The hormone that inducing adipocyte decomposes）Secretion, accelerate the decomposition combustion of fat and produce energy, while suppress enteron aisle to fat
The absorption of class, it is disorderly so as to effectively control lipid-loweringing, hypoglycemic, hypotensive, elimination fatty liver and enzyme system.
8th, certain kind of berries class fruit fiber element：Help to prevent and treat heart disease, can also reduce the cholesterol in blood, it is soluble fine
Dimension element also contributes to prevent and treat diabetes, reduces carbon dioxide and enters blood, to maintain the balance of glucose in blood, reaches preventing and treating
The effect of diabetes.
Fruit stem cell drugs provided by the invention have promote the production of body fluid to quench thirst, nourishing and suppressing Yang, antiviral, Green Tea Extract, lipid-loweringing
The effect of hypoglycemic；Spices and preservative are not added in product, the nutrition of raw material in itself is kept, is easily absorbed by the body；And
Sweet mouthfeel is tasty, simple for production, is antiviral, Green Tea Extract workable for Chinese 2.97 hundred million cardiovascular and cerebrovasculars, diabetic
The active drug of blood lipid-reducing blood sugar-decreasing；Using science abstraction technique, it is highly enriched degree fruit flavones, while rich in compound vitamin C, E, B,
The biotic component such as the multivitamins such as PP, enzyme and coenzyme, mineral matter, cellulose, natural SOD；Present invention increase fruit stem cell,
Metformin hydrochloride and secondary damages and side effect of the phosphoric acid Xi Gelieting to human body can be improved；In addition, the present invention is high for nine
（High fat of blood, hypertension, fatty liver, hyperglycaemia, high creatinine, high lithemia, high enzyme system, high immune system disorder, high cancer tendency）
There is the effect of certain.
The better embodiment of this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party
Formula, can also be on the premise of this patent objective not be departed from one skilled in the relevant art's possessed knowledge
Make a variety of changes.
Claims (9)
1. a kind of fruit stem cell drugs, it is characterised in that including following raw material：Fruit extract, TSPG, iron sheet stone
Dry measure used in former times, Moringa extract, lycium ruthenicum extract, Glucophage, Xi Gelieting.
2. fruit stem cell drugs according to claim 1, it is characterised in that include the raw material of following parts by weight：Water
15~25 parts of berry extract, 10~30 parts of TSPG, 10~30 parts of dendrobium candidum, 30~60 parts of Moringa extract, black Chinese holly
5~15 parts of Qi extract, 5~25 parts of Glucophage, 5~25 parts of Xi Gelieting.
3. fruit stem cell drugs according to claim 1 or 2, it is characterised in that the fruit extract includes following
The component of parts by weight：0.1~1 part of ellagic acid, 1~2 part of anthocyanidin, 0.1~1 part of superoxide dismutase, B B-complex
0.1~1 part, 0.5~2 part of salicylic acid, 0.1~1 part of fruit flavones, 0.2~2 part of fruit cellulose.
4. fruit stem cell drugs according to claim 3, it is characterised in that also including calcium and magnesium.
5. fruit stem cell drugs according to claim 4, it is characterised in that include the raw material of following parts by weight：Calcium
0.1~1 part, 0.1~1 part of magnesium.
6. fruit stem cell drugs according to claim 4, it is characterised in that the active ingredient in the dendrobium candidum
For：Dendrobium candidum element A, dendrobium candidum element B, dendrobium candidum element C, dendrobium candidum element D, dendrobium candidum element E, dendrobium candidum element F, iron
Skin stem of noble dendrobium element G, dendrobium candidum element H, dendrobium candidum element I, dendrobium candidum element J, dendrobium candidum element K, dendrobium candidum element L, iron sheet stone
Dry measure used in former times element M, dendrobium candidum element N, dendrobium candidum element O, dendrobium candidum element P and dendrobium candidum element Q.
7. fruit stem cell drugs according to claim 4, it is characterised in that the fruit extract from card nurse fruit, Ah
Extracted in one or more in Say fruit and raspberry；The TSPG extracts from American Ginseng.
8. fruit stem cell drugs according to claim 4, it is characterised in that the extraction of the fruit flavones, including with
Lower step：A. it will immediately dry, be stored in standby at drying after one or more harvestings in card nurse fruit, A Sayi fruits and raspberry
With；B. the one or more in card nurse fruit, A Sayi fruits and raspberry are crushed, it is 0.4~0.6% then to add mass fraction
In sodium hydroxide solution, 70~90 DEG C are heated to, is incubated 1 hour；Extraction 3 times, preceding 1~2h of time twice, when third time is extracted
Between be 30min, extract solution is merged after extraction, then filtered；C. the extract solution after filtering being concentrated, concentration reaches 40~
When 50%, 95% second ferment of 3 times of volumes is added into concentrate, solution alcohol content is reached 70%；Refrigeration, makes most of shallow lake
Powder, pectin, protein, mucilaginous substance precipitation, are refiltered；D. the alcoholic solution after filtering is distilled, reclaims ethanol, the condensed cream of gained
As fruit flavones.
9. a kind of preparation method of fruit stem cell drugs as claimed in claim 4, it is characterised in that comprise the following steps：
（1）By fruit extract, TSPG, dendrobium candidum, Moringa extract, lycium ruthenicum extract, Glucophage and Xi Gelieting
Mixing, pre-freeze 2 hours at a temperature of being placed in -50~-30 DEG C；- 35~-20 DEG C are then heated to, drying for lyophilized medicine is carried out and rises
Chinese workers' sequence, absolute pressure are 4~7Pa, 60 DEG C of drying temperature, total 18 hours drying times；Then >=room temperature is gradually heating to, is added
Enter calcium and magnesium, be well mixed；（2）Tabletting, envionmental humidity during compression molding are controlled below 60%；（3）It is filling, sterilizing,
Produce.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711010971.4A CN107648596A (en) | 2017-10-26 | 2017-10-26 | A kind of fruit stem cell drugs and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711010971.4A CN107648596A (en) | 2017-10-26 | 2017-10-26 | A kind of fruit stem cell drugs and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107648596A true CN107648596A (en) | 2018-02-02 |
Family
ID=61119299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711010971.4A Pending CN107648596A (en) | 2017-10-26 | 2017-10-26 | A kind of fruit stem cell drugs and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107648596A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1463725A (en) * | 2002-06-11 | 2003-12-31 | 于炳信 | A pharmaceutical compound for treating diabetes and insuline resistance syndrome |
| CN1524543A (en) * | 2003-02-26 | 2004-09-01 | 天津市长生基因生物工程有限公司 | Medicament formulation for preventing and treating diabetes complication and preparation method therefor |
| CN1788755A (en) * | 2004-12-14 | 2006-06-21 | 北京市农林科学院 | Framberry leaf extract effective part and its composition and uses |
| CN103142720A (en) * | 2013-02-27 | 2013-06-12 | 辽宁大学 | Application of black raspberry extract in preparing anti-diabetic medicine |
| US20150366863A1 (en) * | 2013-03-28 | 2015-12-24 | Wockhardt Limited | Solid oral pharmaceutical compositions comprising fixed dose combination of metformin and sitagliptin or salts thereof |
| CN105535553A (en) * | 2016-03-10 | 2016-05-04 | 厦门塔斯曼生物工程有限公司 | Formula for regulating blood sugar of human body |
-
2017
- 2017-10-26 CN CN201711010971.4A patent/CN107648596A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1463725A (en) * | 2002-06-11 | 2003-12-31 | 于炳信 | A pharmaceutical compound for treating diabetes and insuline resistance syndrome |
| CN1524543A (en) * | 2003-02-26 | 2004-09-01 | 天津市长生基因生物工程有限公司 | Medicament formulation for preventing and treating diabetes complication and preparation method therefor |
| CN1788755A (en) * | 2004-12-14 | 2006-06-21 | 北京市农林科学院 | Framberry leaf extract effective part and its composition and uses |
| CN103142720A (en) * | 2013-02-27 | 2013-06-12 | 辽宁大学 | Application of black raspberry extract in preparing anti-diabetic medicine |
| US20150366863A1 (en) * | 2013-03-28 | 2015-12-24 | Wockhardt Limited | Solid oral pharmaceutical compositions comprising fixed dose combination of metformin and sitagliptin or salts thereof |
| CN105535553A (en) * | 2016-03-10 | 2016-05-04 | 厦门塔斯曼生物工程有限公司 | Formula for regulating blood sugar of human body |
Non-Patent Citations (4)
| Title |
|---|
| 孟宪军等: "《中国小浆果深加工技术》", 31 August 2012, 中国轻工业出版社 * |
| 方闯烈等: "《神奇珠峰 魅力定日》", 31 March 2016, 上海人民出版社 * |
| 盛军: "《现代辣木学》", 31 January 2015, 云南科技出版社 * |
| 谢东浩等: "《常用治疗肿瘤中药》", 31 October 2015, 中国医药科技出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103750328B (en) | A kind of freeze drying compound berry Ultramicro-powder and production method thereof | |
| CN104920687A (en) | Health-maintenance jasmine black tea and processing method thereof | |
| CN108391774A (en) | A kind of drinks of antigout and preparation method thereof | |
| CN107319086A (en) | A kind of matrimony vine spun gold emperor chrysanthemum pressed candy and preparation method thereof | |
| CN102657278A (en) | Asparagus healthcare tea | |
| CN106562413A (en) | Oral thick paste for immunity enhancement and preparation method thereof | |
| CN104323281A (en) | Aqueous piny flower and poria cocos composition as well as preparation method and application of aqueous piny flower and poria cocos composition | |
| CN107873915A (en) | A kind of matrimony vine ginger jujube tea and preparation method thereof | |
| CN102204610B (en) | Gingko health-care tea | |
| CN107333926A (en) | A kind of Seabuckthorn healthcare tea and its preparation technology | |
| CN109223908A (en) | Composition and purposes rich in green-tea extract and Chinese medical extract | |
| CN105532991A (en) | Composite dark green tea with functions of maintaining beauty and caring skin and preparation method thereof | |
| CN105495620A (en) | Plant extract composition simultaneously having immunological enhancement and blood fat reducing functions | |
| CN109043055A (en) | A kind of herbal tea improving sub-health state | |
| CN105707888A (en) | Nutritious oatmeal capable of clearing away heat and toxic materials and preparation method thereof | |
| CN107648596A (en) | A kind of fruit stem cell drugs and preparation method thereof | |
| CN103168878A (en) | Three leaf tea containing Rosa roxburghii | |
| CN104474406A (en) | Health traditional Chinese medicine wine for nourishing yin and moistening lung and preparation method of health traditional Chinese medicine wine | |
| CN104383265A (en) | Codonopsis pilosulae-ginseng traditional Chinese medicine wine for tonifying qi and preserving health and preparation method of codonopsis pilosulae-ginseng traditional Chinese medicine wine | |
| KR20210041387A (en) | A natural tea removing the effect of hangover contained the extract material in arrowroot blossoms and Plantago ovata | |
| CN110050934A (en) | A kind of pueraria lobata pawpaw solid beverage and preparation method thereof | |
| CN104371892A (en) | Fleece-flower root hair-blacking traditional Chinese medicine wine and preparation method thereof | |
| CN105326755B (en) | Additive-free mung bean anti-acne maintenance face paper and its Green production method | |
| CN109170052A (en) | A kind of dendrobium nobile stomach-nourishing health tea and preparation method thereof | |
| CN108783443A (en) | A kind of tablet and preparation method thereof for internal organs conditioning |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180202 |