CN107648452A - Pharmaceutical composition of low fever and preparation method thereof after a kind of gynemetrics's iatrotechnics - Google Patents

Pharmaceutical composition of low fever and preparation method thereof after a kind of gynemetrics's iatrotechnics Download PDF

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CN107648452A
CN107648452A CN201711137017.1A CN201711137017A CN107648452A CN 107648452 A CN107648452 A CN 107648452A CN 201711137017 A CN201711137017 A CN 201711137017A CN 107648452 A CN107648452 A CN 107648452A
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parts
gynemetrics
iatrotechnics
powder
pharmaceutical composition
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张云祥
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Hangzhou Guang Kai medical science and Technology Development Co., Ltd.
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Beijing Yu Splendid Technology Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract

The invention discloses a kind of pharmaceutical composition of low fever after gynemetrics's iatrotechnics, it is made up of the raw material of following parts by weight：6 10 parts of the Radix Astragali, 7 12 parts of radix pseudostellariae, 39 parts of the bighead atractylodes rhizome, 5 10 parts of sweet wormwood, 39 parts of the root of straight ladybell, 8 12 parts of the tuber of dwarf lilyturf, 26 parts of the fruit of Chinese magnoliavine, 7 12 parts of the root bark of Chinese wolf-berry.The medicine of the present invention can effectively treat post gynecologic operation low fever, substantially reduce the rehabilitation duration of patient, have no side effect, and medicine cost is relatively low, effectively improves the fitness and quality of life of patient.

Description

Pharmaceutical composition of low fever and preparation method thereof after a kind of gynemetrics's iatrotechnics
Technical field
The invention belongs to gynemetrics's field of medicine preparing technology, and in particular to the medicine of low fever after a kind of gynemetrics's iatrotechnics Compositions and preparation method thereof.
Background technology
After gynaecology and obstetrics operation, in Conventional antibiotic drip-feed treatment, most patients tend to just for postoperative low 2~3 days Often, but clinically also frequently encounter some patient's wounds without it is red and swollen, blood picture is normal, and the phenomenon do not moved back slowly of generating heat, rather spine Hand.The noninfectious fever category traditional Chinese medical science " fever by internal injury " category after gynaecology and obstetrics operation, patient is specific disease population after gynaecology and obstetrics operation The phase is shorter between body, especially obstetrics' caesarean birth patient are in hospital, and extension of having to because there are the clinical symptoms of such heating is in hospital Time, it is ob-gyn's more stubborn problem.
Patent 201510791380.X discloses a kind of Chinese medicine for treating post gynecologic operation low fever.This kind treats gynemetrics The Chinese medicine of postoperative low fever is by ginger, asarum, Basil, east wind tangerine, Indian Epimeredi Herb, foetid eryngo herb, rattletop, scouring rush, semen sojae germinatum, in vain The root of Dahurian angelica, erigeron breviscapus, the root bark of shaggy-fruited dittany, the bark of ash, devilpepper, butterflybush flower, common nandina leaf, rosy clouds grass, Flos Albiziae, radix glycyrrhizae, the fruit of Chinese wolfberry, longan Meat, donkey-hide gelatin, lily, radix polygonati officinalis are raw material, are formed according to certain weight proportion mixed preparing.The invention medicament categories are various, match somebody with somebody System is complicated, and side effect is big.
201510296293.7 disclose a kind of pharmaceutical composition for treating post gynecologic operation low fever, the drug regimen The bulk drug of thing is by turtle shell, field pennycress, rattletop, Momordica grosvenori, reticulate millettia, sweet wormwood, fritillaria, Paris polyphylla, Herba Andrographitis, the root of kudzu vine, radix glycyrrhizae, white Chinese herbaceous peony, HERBA CIRSII, purslane, honeysuckle, hawthorn, motherwort, cassia twig, kuh-seng, Radix Angelicae Sinensis, the dried immature fruit of citron orange, oldenlandia diffusa, Chinese yam, forge it is male Oyster, bark of ash, dark plum, the fruit of Chinese magnoliavine, Ligusticum wallichii, the bark of official magnolia, jujube composition.The medicine effect is slow, patient's treatment cycle length.
The content of the invention
It is an object of the invention to provide pharmaceutical composition of low fever after a kind of gynemetrics's iatrotechnics and preparation method thereof.
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：Radix Astragali 6- 10 parts, radix pseudostellariae 7-12 parts, bighead atractylodes rhizome 3-9 parts, sweet wormwood 5-10 parts, the root of straight ladybell 3-9 parts, tuber of dwarf lilyturf 8-12 part, fruit of Chinese magnoliavine 2-6 parts, ground bone Skin 7-12 parts.
The medicine also includes radix cynanchi atrati 5-10 parts.
The medicine also includes golden cypress 3-9 parts.
The medicine also includes Charred Triplet 4-8 parts.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) Radix Astragali 6-10 parts are taken, radix pseudostellariae 7-12 parts, bighead atractylodes rhizome 3-9 parts, mixing, are clayed into power, add 4-6 times of parts by weight Several water refluxing extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) sweet wormwood 5-10 parts are taken, the root of straight ladybell 3-9 parts, tuber of dwarf lilyturf 8-12 part, is put into marmite, does not have with water logging, be heated to 70-80 DEG C, boiling 2-4 hours, 2 parts of tartaric acid, then boiling 6-8 hours are added, is cooled to room temperature, 2-4 hours is stood, takes supernatant, is steamed It is drying into powder B；
(3) fruit of Chinese magnoliavine 2-6 parts are taken, root bark of Chinese wolf-berry 7-12 parts, add 0.1-0.4 part yeast fermentation broths, 28-32 DEG C of fermentation 4-6 My god, dry or dry, clay into power, the water refluxing extraction of 3-5 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder is made C；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 3-5 × 10 in the yeast fermentation broth5cfu。
Radix cynanchi atrati 5-10 parts are additionally added in the step (1).
Golden cypress 3-9 parts are additionally added in the step (2).
Charred Triplet 4-8 parts are additionally added in the step (3).
Beneficial effects of the present invention：Post gynecologic operation low fever can be effectively treated, substantially reduces the rehabilitation duration of patient, Have no side effect, and medicine cost is relatively low, effectively improves the fitness and quality of life of patient.
Embodiment
With reference to specific embodiment, the present invention will be further described.
Embodiment 1
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, mixing, is clayed into power, adds the water backflow of 5 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 75 DEG C, boiling 3 is small When, 2 parts of tartaric acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, adds 0.3 part of yeast fermentation broth, 30 DEG C ferment 5 days, dry or dry, Clay into power, the water refluxing extraction of 4 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 4 × 10 in the yeast fermentation broth5cfu。
Embodiment 2
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 6 Part, 7 parts of radix pseudostellariae, 3 parts of the bighead atractylodes rhizome, 5 parts of sweet wormwood, 3 parts of the root of straight ladybell, 8 parts of the tuber of dwarf lilyturf, 2 parts of the fruit of Chinese magnoliavine, 7 parts of the root bark of Chinese wolf-berry.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 6 parts of the Radix Astragali is taken, 7 parts of radix pseudostellariae, 3 parts of the bighead atractylodes rhizome, mixing, is clayed into power, adds the water backflow of 4 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 5 parts of sweet wormwood is taken, 3 parts of the root of straight ladybell, 8 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 70 DEG C, boiling 2 is small When, 2 parts of tartaric acid, then boiling 6 hours are added, is cooled to room temperature, 2 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 2 parts of the fruit of Chinese magnoliavine is taken, 7 parts of the root bark of Chinese wolf-berry, adds 0.1 part of yeast fermentation broth, 28 DEG C ferment 4 days, dry or dry, Clay into power, the water refluxing extraction of 3 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 3 × 10 in the yeast fermentation broth5cfu。
Embodiment 3
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 10 Part, 12 parts of radix pseudostellariae, 9 parts of the bighead atractylodes rhizome, 10 parts of sweet wormwood, 9 parts of the root of straight ladybell, 12 parts of the tuber of dwarf lilyturf, 6 parts of the fruit of Chinese magnoliavine, 12 parts of the root bark of Chinese wolf-berry.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 10 parts of the Radix Astragali is taken, 12 parts of radix pseudostellariae, 9 parts of the bighead atractylodes rhizome, mixing, is clayed into power, the water for adding 6 times of parts by weight returns Stream extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 10 parts of sweet wormwood is taken, 9 parts of the root of straight ladybell, 12 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 80 DEG C, boiling 4 is small When, 2 parts of tartaric acid, then boiling 8 hours are added, is cooled to room temperature, 4 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 6 parts of the fruit of Chinese magnoliavine is taken, 12 parts of the root bark of Chinese wolf-berry, adds 0.4 part of yeast fermentation broth, 32 DEG C ferment 6 days, dry or dry, Clay into power, the water refluxing extraction of 5 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 5 × 10 in the yeast fermentation broth5cfu。
Embodiment 4
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry, radix cynanchi atrati 5-10 Part.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, radix cynanchi atrati 5-10 parts, mixing, is clayed into power, adds 5 times of weight The water refluxing extraction of number 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 75 DEG C, boiling 3 is small When, 2 parts of tartaric acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, adds 0.3 part of yeast fermentation broth, 30 DEG C ferment 5 days, dry or dry, Clay into power, the water refluxing extraction of 4 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 4 × 10 in the yeast fermentation broth5cfu。
Embodiment 5
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry, golden cypress 3-9 Part.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, mixing, is clayed into power, adds the water backflow of 5 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, golden cypress 3-9 parts, is put into marmite, does not have with water logging, be heated to 75 DEG C, boiling 3 hours, 2 parts of tartaric acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and be made Powder B；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, adds 0.3 part of yeast fermentation broth, 30 DEG C ferment 5 days, dry or dry, Clay into power, the water refluxing extraction of 4 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 4 × 10 in the yeast fermentation broth5cfu。
Embodiment 6
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry, Charred Triplet 4-8 Part.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, mixing, is clayed into power, adds the water backflow of 5 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 75 DEG C, boiling 3 is small When, 2 parts of tartaric acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, Charred Triplet 4-8 parts, adds 0.3 part of yeast fermentation broth, 30 DEG C of fermentations 5 My god, dry or dry, clay into power, the water refluxing extraction of 4 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 4 × 10 in the yeast fermentation broth5cfu。
Embodiment 7
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry, seven 5-10 of sand Part.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, husky seven 5-10 parts, mixing, clays into power, adds 5 times of weight The water refluxing extraction of number 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 75 DEG C, boiling 3 is small When, 2 parts of tartaric acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, adds 0.3 part of yeast fermentation broth, 30 DEG C ferment 5 days, dry or dry, Clay into power, the water refluxing extraction of 4 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 4 × 10 in the yeast fermentation broth5cfu。
Embodiment 8
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry, manyflower jasmine herb or flower 3-9 Part.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, mixing, is clayed into power, adds the water backflow of 5 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 75 DEG C, boiling 3 is small When, 2 parts of tartaric acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, manyflower jasmine herb or flower 3-9 parts, adds 0.3 part of yeast fermentation broth, 30 DEG C of fermentations 5 My god, dry or dry, clay into power, the water refluxing extraction of 4 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 4 × 10 in the yeast fermentation broth5cfu。
Embodiment 9
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, mixing, is clayed into power, adds the water backflow of 5 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 75 DEG C, boiling 3 is small When, 2 parts of tartaric acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, adds 0.3 part of Lactobacillus plantarum, 30 DEG C ferment 5 days, dry or dry, Clay into power, the water refluxing extraction of 4 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
The Lactobacillus plantarum content is 4 × 105cfu。
Comparative example 1
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, mixing, is clayed into power, adds the water backflow of 5 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 75 DEG C, boiling 3 is small When, 2 parts of tartaric acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, adds 0.3 part of acetobacter xylinum, 30 DEG C ferment 5 days, dry or dry, and grind Into powder, the water refluxing extraction of 4 times of parts by weight of addition 3 times, merging filtrate, it is evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
The acetobacter xylinum content is 4 × 105cfu。
Comparative example 2
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, mixing, is clayed into power, adds the water backflow of 5 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 75 DEG C, boiling 3 is small When, 2 parts of acetic acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, adds 0.3 part of yeast fermentation broth, 30 DEG C ferment 5 days, dry or dry, Clay into power, the water refluxing extraction of 4 times of parts by weight of addition 3 times, merging filtrate, be evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Yeast bacterial content is 4 × 10 in the yeast fermentation broth5cfu。
Comparative example 3
The pharmaceutical composition of low fever, is made up of the raw material of following parts by weight after a kind of gynemetrics's iatrotechnics：The Radix Astragali 8 Part, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, 8 parts of sweet wormwood, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, 4 parts of the fruit of Chinese magnoliavine, 10 parts of the root bark of Chinese wolf-berry.
The preparation method of the pharmaceutical composition of low fever, is carried out in accordance with the following steps after gynemetrics's iatrotechnics：
(1) 8 parts of the Radix Astragali is taken, 10 parts of radix pseudostellariae, 6 parts of the bighead atractylodes rhizome, mixing, is clayed into power, adds the water backflow of 5 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) 8 parts of sweet wormwood is taken, 6 parts of the root of straight ladybell, 10 parts of the tuber of dwarf lilyturf, is put into marmite, does not have with water logging, is heated to 75 DEG C, boiling 3 is small When, 2 parts of tartaric acid, then boiling 7 hours are added, is cooled to room temperature, 3 hours is stood, takes supernatant, be evaporated and powder B is made；
(3) 4 parts of the fruit of Chinese magnoliavine is taken, 10 parts of the root bark of Chinese wolf-berry, dries or dries, clay into power, adds the water backflow of 4 times of parts by weight Extraction 3 times, merging filtrate, is evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
Experimental example 1：
Post gynecologic operation low fever patient 1000 is selected, is divided into 10 groups, every group of 100 people, symptom is 2-3 days antibiotic veins Instil still continuous low fever, but blood picture is normal after treating.Take embodiment 1-7, embodiment 9, comparative example 1-3 medicine, daily 30g, divide 2 times and take, after taking 6, count cure rate, as shown in table 1：
Table 1
As can be seen from Table 1, embodiment 4-6 cure rate is above embodiment 1, compared with Example 1, embodiment 4-6 Other conditions it is identical with embodiment 1, it is only respectively in embodiment 4-6 to add radix cynanchi atrati, golden cypress, Charred Triplet, card more Understand common vetch, golden cypress, the effect of addition of Charred Triplet adds low fever after gynemetrics's iatrotechnics.Embodiment 7, embodiment 9 are controlled More rate is above embodiment 1, and compared with Example 1, the other conditions of embodiment 7 and 9 are identical with embodiment 1, is only It is not in embodiment 7 not add sand seven more, replace yeast fermentation broth with Lactobacillus plantarum in embodiment 9, it was demonstrated that sand seven, plant breast bar The addition of bacterium adds the effect of low fever after gynemetrics's iatrotechnics.The cure rate of comparative example 1 is less than embodiment 9, with embodiment 9 Compare, other experiment conditions are identical, and Lactobacillus plantarum only is replaced with into acetobacter xylinum, it is seen that acetobacter xylinum zymotic fluid After enhancing gynemetrics iatrotechnics the effect of low fever.The cure rate of comparative example 2 is less than embodiment 1, with the phase of embodiment 1 Than other experiment conditions are identical, and tartaric acid only is replaced with into acetic acid, it is seen that acetic acid is added in preparation process and is not had The effect of not strengthening low fever after gynemetrics's iatrotechnics.The cure rate of comparative example 3 is less than embodiment 1, compared with Example 1, Other experiment conditions are identical, only do not add yeast fermentation broth in the processing procedure of step (3), it is seen that yeast ferments The effect of low fever after gynemetrics's iatrotechnics being enhanced after liquid processing.
Experimental example 2：
The postoperative low fever patient of urological department 200 is selected, is divided into 2 groups, every group of 100 people, symptom is that 2-3 days antibiotic veins drip Still continuous low fever, but blood picture is normal after note treatment.Embodiment 1 is taken, the medicine of embodiment 8, daily 30g, divides 2 times and takes, is taken After 6 days, cure rate is counted, as shown in table 2：
Table 2
Group Every group of patient's number Cure rate
Embodiment 1 100 52%
Embodiment 8 100 74%
As can be seen from Table 1, the cure rate of embodiment 8 is significantly larger than embodiment 1, and compared with Example 1, other conditions are complete Exactly the same, only embodiment more than 8 adds manyflower jasmine herb or flower, it is seen that the addition of manyflower jasmine herb or flower is with the treatment postoperative low fever of urological department Effect.

Claims (9)

1. the pharmaceutical composition of low fever after a kind of gynemetrics's iatrotechnics, it is characterised in that by the raw material system of following parts by weight Into：Radix Astragali 6-10 parts, radix pseudostellariae 7-12 parts, bighead atractylodes rhizome 3-9 parts, sweet wormwood 5-10 parts, the root of straight ladybell 3-9 parts, tuber of dwarf lilyturf 8-12 part, fruit of Chinese magnoliavine 2- 6 parts, root bark of Chinese wolf-berry 7-12 parts.
2. according to claim 1 after gynemetrics's iatrotechnics low fever pharmaceutical composition, it is characterised in that the medicine is also Including radix cynanchi atrati 5-10 parts.
3. according to claim 1 after gynemetrics's iatrotechnics low fever pharmaceutical composition, it is characterised in that the medicine is also Including golden cypress 3-9 parts.
4. according to claim 1 after gynemetrics's iatrotechnics low fever pharmaceutical composition, it is characterised in that the medicine is also Including Charred Triplet 4-8 parts.
5. the preparation method of the pharmaceutical composition of low fever after gynemetrics's iatrotechnics described in claim 1, it is characterised in that according to Following steps are carried out：
(1) Radix Astragali 6-10 parts are taken, radix pseudostellariae 7-12 parts, bighead atractylodes rhizome 3-9 parts, mixing, are clayed into power, 4-6 times of parts by weight of addition Water refluxing extraction 3 times, merging filtrate, is evaporated and powders A is made；
(2) sweet wormwood 5-10 parts are taken, the root of straight ladybell 3-9 parts, tuber of dwarf lilyturf 8-12 part, is put into marmite, does not have with water logging, are heated to 70-80 DEG C, are steamed Boil 2-4 hours, add 2 parts of tartaric acid, then boiling 6-8 hours, be cooled to room temperature, stand 2-4 hours, take supernatant, be evaporated system Into powder B；
(3) fruit of Chinese magnoliavine 2-6 parts are taken, root bark of Chinese wolf-berry 7-12 parts, add 0.1-0.4 part yeast fermentation broths, 28-32 DEG C ferments 4-6 days, shines Dry or drying, clays into power, and the water refluxing extraction of 3-5 times of parts by weight of addition 3 times, merging filtrate, is evaporated and powder C is made；
(4) powders A, powder B, powder C are well mixed, load capsule and be made.
6. according to claim 5 after gynemetrics's iatrotechnics low-heat disease drug preparation method, it is characterised in that the yeast Yeast bacterial content is 3-5 × 10 in zymotic fluid5cfu。
7. according to claim 5 after gynemetrics's iatrotechnics low-heat disease drug preparation method, it is characterised in that the step (1) radix cynanchi atrati 5-10 parts are additionally added in.
8. according to claim 5 after gynemetrics's iatrotechnics low-heat disease drug preparation method, it is characterised in that the step (2) golden cypress 3-9 parts are additionally added in.
9. according to claim 5 after gynemetrics's iatrotechnics low-heat disease drug preparation method, it is characterised in that the step (3) Charred Triplet 4-8 parts are additionally added in.
CN201711137017.1A 2017-11-16 2017-11-16 Pharmaceutical composition of low fever and preparation method thereof after a kind of gynemetrics's iatrotechnics Withdrawn CN107648452A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108498737A (en) * 2018-06-06 2018-09-07 青岛市妇女儿童医院（青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心） Chinese medicine composition, preparation method and therapeutic device for treating post gynecologic operation low fever
CN111281896A (en) * 2020-02-14 2020-06-16 昆明加加宁生物制品有限公司 Composite microbial inoculum for adjusting micro-ecological balance of gynecology

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108498737A (en) * 2018-06-06 2018-09-07 青岛市妇女儿童医院（青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心） Chinese medicine composition, preparation method and therapeutic device for treating post gynecologic operation low fever
CN111281896A (en) * 2020-02-14 2020-06-16 昆明加加宁生物制品有限公司 Composite microbial inoculum for adjusting micro-ecological balance of gynecology

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