CN107648393A - Chinese medicine composition, preparation method and applications and Chinese medicine preparation and preparation method thereof - Google Patents
Chinese medicine composition, preparation method and applications and Chinese medicine preparation and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention discloses a kind of Chinese medicine composition, preparation method and applications and Chinese medicine preparation and preparation method thereof；The traditional Chinese medicine composite includes：5~40 parts of pseudo-ginseng, 5~40 parts of safflower, 10~45 parts of Asian puccoon, 10~45 parts of giant knotweed, 5~40 parts of rheum officinale, 5~40 parts of the Radix Astragali, 5~40 parts of rhizoma atractylodis, 5~40 parts of the root bark of shaggy-fruited dittany, 5~40 parts of Chinese gall, 5~40 parts of golden cypress, 5~40 parts of folium artemisiae argyi, 5~40 parts of kuh-seng, 5~40 parts of frutus cnidii；The Chinese medicine composition and Chinese medicine preparation can effectively alleviate burn and scald, and quick, significant effect；Simultaneously, additionally it is possible to alleviate sore stubborn dermatitis, traumatism and bleeding and pruitus；In addition, have no toxic side effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition, preparation method and applications and Chinese medicine
Preparation and preparation method thereof.
Background technology
Burn and scald, is common unexpected injury in life, and boiling water, rolling congee, deep fat, the burning of vapours is scalded can often occur
Thing.To some burn and scalds, if processing is timely, bad consequence would not be caused.And the medicine of existing various treatment burn and scalds
Product, mostly Western medicine, cost is high, and side effect is big, and is taken effect slowly after.
The content of the invention
In view of this, this application provides a kind of Chinese medicine composition, preparation method and applications and Chinese medicine preparation and its system
Preparation Method；The Chinese medicine composition and Chinese medicine preparation can effectively alleviate burn and scald, and quick, significant effect；Simultaneously, moreover it is possible to
Enough alleviate sore stubborn dermatitis, traumatism and bleeding and pruitus；In addition, have no toxic side effect.
To solve above technical problem, technical scheme provided by the invention is a kind of Chinese medicine composition, in parts by weight, institute
Stating traditional Chinese medicine composite includes：5~40 parts of pseudo-ginseng, 5~40 parts of safflower, 10~45 parts of Asian puccoon, 10~45 parts of giant knotweed, rheum officinale
5~40 parts, 5~40 parts of the Radix Astragali, 5~40 parts of rhizoma atractylodis, 5~40 parts of the root bark of shaggy-fruited dittany, 5~40 parts of Chinese gall, 5~40 parts of golden cypress, folium artemisiae argyi 5
~40 parts, kuh-seng 5~4 0 part, 5~40 parts of frutus cnidii.
Preferably, in parts by weight, the traditional Chinese medicine composite includes：10~30 parts of pseudo-ginseng, 10~30 parts of safflower,
15~35 parts of Asian puccoon, 15~35 parts of giant knotweed, 10~30 parts of rheum officinale, 10~30 parts of the Radix Astragali, 10~30 parts of rhizoma atractylodis, the root bark of shaggy-fruited dittany 10~30
Part, 10~30 parts of Chinese gall, 10~30 parts of golden cypress, 10~30 parts of folium artemisiae argyi, 10~30 parts of kuh-seng, 10~30 parts of frutus cnidii.It is preferred that
, in parts by weight, the traditional Chinese medicine composite includes：It is 20 parts of pseudo-ginseng, 20 parts of safflower, 23 parts of Asian puccoon, 23 parts of giant knotweed, big
Yellow 20 parts, 20 parts of the Radix Astragali, 20 parts of rhizoma atractylodis, 20 parts of the root bark of shaggy-fruited dittany, 20 parts of Chinese gall, 20 parts of golden cypress, 20 parts of folium artemisiae argyi, 20 parts of kuh-seng, snake
20 parts of machine tool.
Preferably, in parts by weight, the traditional Chinese medicine composite also includes：1~5 part of borneol, 1~5 part of menthol.
Preferably, in parts by weight, the traditional Chinese medicine composite also includes：3 parts of borneol, 3 parts of menthol.
Present invention also offers a kind of preparation method of Chinese medicine composition, comprise the following steps：In parts by weight, pseudo-ginseng is taken
5~40 parts, 5~40 parts of safflower, 10~45 parts of Asian puccoon, 10~45 parts of giant knotweed, 5~40 parts of rheum officinale, 5~40 parts of the Radix Astragali, rhizoma atractylodis 5
~40 parts, 5~40 parts of the root bark of shaggy-fruited dittany, 5~40 parts of Chinese gall, 5~40 parts of golden cypress, 5~40 parts of folium artemisiae argyi, 5~40 parts of kuh-seng, frutus cnidii
5~40 parts of crushing, mixing, solvent extraction, filterings, both.
Preferably, the solvent extracting process is specially：With the closed immersion of ethanol.
Preferably, the solvent extracting process is specially：With the closed immersion of 75% ethanol 14 days.
Preferably, the step is specially：
1) take 5~40 parts of pseudo-ginseng, 5~40 parts of safflower, 10~45 parts of Asian puccoon, 10~45 parts of giant knotweed, 5~40 parts of rheum officinale,
5~40 parts of the Radix Astragali, 5~40 parts of rhizoma atractylodis, 5~40 parts of the root bark of shaggy-fruited dittany, 5~40 parts of Chinese gall, 5~40 parts of golden cypress, 5~40 parts of folium artemisiae argyi,
5~40 parts of kuh-seng, frutus cnidii 5~40 parts of crushing, mixing, solvent extraction, filterings, obtain first material；
2) 1~5 part of 1~5 part of borneol, menthol dissolving are taken, obtains second material；
3) first material and the second material are mixed, both.
Preferably, the step 2) is specially：1~5 part of 1~5 part of borneol, menthol ethanol dissolving are taken, obtains the second thing
Material.
Preferably, the step 3) is specially：The first material and the second material are mixed, standing takes supernatant,
Both.
Preferably, the standing process time of repose is more than 12h.
Present invention also offers the Chinese medicine composition according to prepared by above-mentioned Chinese medicine composition or above-mentioned preparation method
Prepare alleviate burn and scald, sore stubborn dermatitis, traumatism and bleeding, pruitus medicine in application.
Present invention also offers a kind of Chinese medicine preparation, the above-mentioned Chinese medicine composition of the Chinese medicine preparation and pharmaceutically acceptable
Auxiliary material be made.
Preferably, the formulation of the Chinese medicine preparation is paste, liniment or spray.
Present invention also offers a kind of preparation method of Chinese medicine preparation, comprise the following steps：
1) 5~40 parts of pseudo-ginseng, 5~40 parts of safflower, 10~45 parts of Asian puccoon, 10~45 parts of giant knotweed, big in parts by weight, is taken
Yellow 5~40 parts, 5~40 parts of the Radix Astragali, 5~40 parts of rhizoma atractylodis, 5~40 parts of the root bark of shaggy-fruited dittany, 5~40 parts of Chinese gall, 5~40 parts of golden cypress, Chinese mugwort
5~40 parts of leaf, 5~40 parts of kuh-seng, frutus cnidii 5~40 parts of crushing, mixing, solvent extraction, filterings, both；
2) 1~5 part of borneol, 1~5 part of menthol, 1~6 part of mixing of Tween 80, dissolving are taken, adds flavoring essence 1~2
Part, obtain second material；
3) first material and the second material are mixed, both.
Pseudo-ginseng：It is using the root of plant pseudo-ginseng as medicinal effects, there is the effect of dissipate stasis of blood hemostasis, detumescence ding-tong, cure mainly
Spitting of blood, spit blood, bleeding from five sense organs or subcutaneous tissue, have blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, fall servant's swelling and pain.
Safflower：It is a kind of iridaceous flowering perennial, there is calmness, eliminating the phlegm, spasmolysis, for stomach trouble, menstruation regulating, fiber crops
Rash, heating, the treatment of jaundice, hepatosplenomegaly
Asian puccoon：Have cool blood for the plant of Boraginaceae Lithospermum, invigorate blood circulation, detoxify promoting eruption the effect of, for blood-heat and toxin exuberance, macula
Purple black, measles without adequate eruption, sore, eczema, scald.
Giant knotweed：It is a kind of polygonaceae plant, for jaundice with damp-heat pathogen, stranguria with turbid discharge, under band, arthralgia pain due to rheumatism, carbuncle sore tumefacting virus, extreme misery scalds
Wound, Amenorrhea, abdominal mass, instep play damage, the treatment of cough with lung heat.
Rheum officinale：It is being collectively referred to as the perennial plant of a variety of polygonaceae Rheums, cures mainly real heat constipation；The thermojunction feeling of stuffiness in chest；It is damp and hot to rush down
Dysentery；Jaundice；Gonorrhoea；Oedema abdomen is expired；Difficult urination；Hot eyes；Abscess of throat；Aphthae；Gastropyretic vomiting；Spit blood；Spitting of blood；Nosebleed
Blood；Have blood in stool；Hematuria；Store blood；Amenorrhea；Postpartum stasis of blood；Lumps in the chest and abdomen；Traumatic injury；Heat toxin large carbuncle；Erysipelas；Scald.
The Radix Astragali：There are enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and antibacterial action.
Rhizoma atractylodis：Rhizoma atractylodis root-like stock is used as medicine, and to transport spleen medicine, Wen Xinlie bitter in taste, has eliminating dampness, changes turbid, analgesic effect.
Chinese gall：It is that times aphid colonizes in the insect gall formed in host's Anacardiaceae plant leaf tissue and grown up, cures mainly
Chronic cough of deficiency lung；Spontaneous sweating；Protracted dysentery chronic diarrhea；Prolapse of the anus；Seminal emission；Gonorrhoea；Various bleedings；Carbuncle swells boil.
Golden cypress：For the dry bark of rutaceae wampee or cork tree, hot dysentery is cured mainly, diarrhea, is quenched one's thirst, jaundice , crippling wilts,
Nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leukorrhea, hectic fever due to yin labor heat, red eye, swell pain, aphthae, sore swollen toxin.
Folium artemisiae argyi：For spitting blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, menorrhalgia, blood under threatened abortion, few abdomen crymodynia, through uncomfortable, uterus cold infertile of trembling with fear；
Control pruitus outside.Vinegar Chinese mugwort charcoal warming channel for arresting bleeding, for deficient cold type bleeding.
Folium artemisiae argyi folium artemisiae argyi folium artemisiae argyi folium artemisiae argyi kuh-seng：For the dry root of legume kuh-seng, there are heat-clearing and damp-drying drug, desinsection, the work(of diuresis.
For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy, control trichomonad outside
Property vaginitis.
Frutus cnidii：Cure mainly eliminating dampness, wind-dispelling, desinsection, warming kidney and enhancing body.For impotence, Gong Leng, morbid leucorrhoea duye, arthritis with fixed pain caused by dampness pain in the back；Outside
Control eczema of vulva, married woman's pruritus vulvae, trichomonas vaginitis.
Borneol：Acrid flavour, hardship, are slightly cold；The thoughts of returning home, liver, lung channel；Delicate fragrance a surname dissipate, has inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison, and improving eyesight is moved back
The effect of screen, cure mainly high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, apoplexy coma due to blocking of the respiratory system shies epilepsy, summer-heat and damp blinds clear key, throat deafness, aphtha tooth swells, sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites
Hemorrhoid, red eye, swell pain, pterygium.
Menthol：Menthol is acted on skin or mucous membrane, is there is refrigerant antipruritic work by being extracted in the leaf and stem of peppermint
With；It is for oral administration to be used as carminative, for headache and nose；Pharynx；Laryngitis etc..
Compared with prior art, its detailed description is as follows by the application：
The present invention provides a kind of Chinese medicine composition, preparation method and applications and Chinese medicine preparation and preparation method thereof.In this
Drug composition material is compounded according to monarch, and interaction, raw material includes：It is pseudo-ginseng, safflower, Asian puccoon, giant knotweed, big
Huang, the Radix Astragali, rhizoma atractylodis, the root bark of shaggy-fruited dittany, Chinese gall, golden cypress, folium artemisiae argyi, kuh-seng, frutus cnidii, it is further that borneol, menthol can be may also include
Curative effect is improved, can effectively alleviate burn and scald, and quick, significant effect；Simultaneously, additionally it is possible to alleviate sore stubborn dermatitis, wound goes out
Blood and pruitus；In addition, have no toxic side effect.
Embodiment
In order that those skilled in the art more fully understands technical scheme, with reference to specific embodiment pair
The present invention is described in further detail.
Embodiment 1
A kind of Chinese medicine composition, the traditional Chinese medicine composite include：Pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed
23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, root bark of shaggy-fruited dittany 20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, cnidium monnieri
Sub- 20g.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
Take pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed 23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, the root bark of shaggy-fruited dittany
20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, frutus cnidii 20g are crushed, mixed, soaking 14 with 75% ethanol is closed
My god, filtering, both.
Embodiment 2
A kind of Chinese medicine composition, the traditional Chinese medicine composite include：Pseudo-ginseng 5g, safflower 5g, Asian puccoon 10g, giant knotweed
10g, rheum officinale 5g, Radix Astragali 5g, rhizoma atractylodis 5g, root bark of shaggy-fruited dittany 5g, Chinese gall 5g, golden cypress 5g, folium artemisiae argyi 55g, kuh-seng 5g, frutus cnidii 5g.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
Take pseudo-ginseng 5g, safflower 5g, Asian puccoon 10g, giant knotweed 10g, rheum officinale 5g, Radix Astragali 5g, rhizoma atractylodis 5g, root bark of shaggy-fruited dittany 5g, five times
Sub- 5g, golden cypress 5g, folium artemisiae argyi 5g, kuh-seng 5g, frutus cnidii 5g are crushed, mixed, soaking 14 days, filtering with 75% ethanol is closed, both.
Embodiment 3
A kind of Chinese medicine composition, the traditional Chinese medicine composite include：Take pseudo-ginseng 10g, safflower 10g, Asian puccoon 15g, tiger
Cane 15g, rheum officinale 10g, Radix Astragali 10g, rhizoma atractylodis 10g, root bark of shaggy-fruited dittany 10g, Chinese gall 10g, golden cypress 10g, folium artemisiae argyi 10g, kuh-seng 10g, snake
Machine tool 10g.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
Take pseudo-ginseng 10g, safflower 10g, Asian puccoon 15g, giant knotweed 15g, rheum officinale 10g, Radix Astragali 10g, rhizoma atractylodis 10g, the root bark of shaggy-fruited dittany
10g, Chinese gall 10g, golden cypress 10g, folium artemisiae argyi 10g, kuh-seng 10g, frutus cnidii 10g are crushed, mixed, soaking 14 with 75% ethanol is closed
My god, filtering, both.
Embodiment 4
A kind of Chinese medicine composition, the traditional Chinese medicine composite include：Take pseudo-ginseng 30g, safflower 30g, Asian puccoon 35g, tiger
Cane 35g, rheum officinale 30g, Radix Astragali 30g, rhizoma atractylodis 30g, root bark of shaggy-fruited dittany 30g, Chinese gall 30g, golden cypress 30g, folium artemisiae argyi 30g, kuh-seng 30g, snake
Machine tool 30g.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
Take pseudo-ginseng 30g, safflower 30g, Asian puccoon 35g, giant knotweed 35g, rheum officinale 30g, Radix Astragali 30g, rhizoma atractylodis 30g, the root bark of shaggy-fruited dittany
30g, Chinese gall 30g, golden cypress 30g, folium artemisiae argyi 30g, kuh-seng 30g, frutus cnidii 30g are crushed, mixed, soaking 14 with 75% ethanol is closed
My god, filtering, both.
Embodiment 5
A kind of Chinese medicine composition, the traditional Chinese medicine composite include：Take pseudo-ginseng 10g, safflower 10g, Asian puccoon 15g, tiger
Cane 15g, rheum officinale 10g, Radix Astragali 10g, rhizoma atractylodis 10g, root bark of shaggy-fruited dittany 10g, Chinese gall 10g, golden cypress 10g, folium artemisiae argyi 10g, kuh-seng 10g, snake
Machine tool 10g.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
Take pseudo-ginseng 40g, safflower 40g, Asian puccoon 45g, giant knotweed 45g, rheum officinale 40g, Radix Astragali 40g, rhizoma atractylodis 40g, the root bark of shaggy-fruited dittany
40g, Chinese gall 40g, golden cypress 40g, folium artemisiae argyi 40g, kuh-seng 40g, frutus cnidii 40g are crushed, mixed, soaking 14 with 75% ethanol is closed
My god, filtering, both.
Embodiment 6
A kind of Chinese medicine composition, the traditional Chinese medicine composite include：Pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed
23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, root bark of shaggy-fruited dittany 20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, cnidium monnieri
Sub- 20g, borneol 3g, menthol 3g.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
1) pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed 23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, the root bark of shaggy-fruited dittany
20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, frutus cnidii 20g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) borneol 3g, menthol 3g mixing, the dissolving of 95% ethanol are taken, obtains second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 7
A kind of Chinese medicine composition, the traditional Chinese medicine composite include：Pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed
23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, root bark of shaggy-fruited dittany 20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, cnidium monnieri
Sub- 20g, borneol 1g, menthol 1g.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
1) pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed 23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, the root bark of shaggy-fruited dittany
20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, frutus cnidii 20g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) borneol 1g, menthol 1g mixing, the dissolving of 95% ethanol are taken, obtains second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 8
A kind of Chinese medicine composition, the traditional Chinese medicine composite include：Pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed
23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, root bark of shaggy-fruited dittany 20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, cnidium monnieri
Sub- 20g, borneol 5g, menthol 5g.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
1) pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed 23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, the root bark of shaggy-fruited dittany
20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, frutus cnidii 20g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) borneol 5g, menthol 5g mixing, the dissolving of 95% ethanol are taken, obtains second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 9
Chinese medicine preparation is made up of the Chinese medicine composition and pharmaceutically acceptable auxiliary material of embodiment 1.
Auxiliary material is：1~6g of Tween 80,1~2g of flavoring essence.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps：
1) pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed 23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, the root bark of shaggy-fruited dittany are taken
20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, frutus cnidii 20g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) take 1~6g95% of Tween 80 ethanol to dissolve, add 1~2g of flavoring essence, obtain second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 10
Chinese medicine preparation is made up of the Chinese medicine composition and pharmaceutically acceptable auxiliary material of embodiment 2.
Auxiliary material is：1~6g of Tween 80,1~2g of flavoring essence.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps：
1) pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed 23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, the root bark of shaggy-fruited dittany are taken
20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, frutus cnidii 20g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) take 1~6g95% of Tween 80 ethanol to dissolve, add 1~2g of flavoring essence, obtain second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 11
Chinese medicine preparation is made up of the Chinese medicine composition and pharmaceutically acceptable auxiliary material of embodiment 3.
Auxiliary material is：1~6g of Tween 80,1~2g of flavoring essence.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps：
1) pseudo-ginseng 10g, safflower 10g, Asian puccoon 15g, giant knotweed 15g, rheum officinale 10g, Radix Astragali 10g, rhizoma atractylodis 10g, the root bark of shaggy-fruited dittany are taken
10g, Chinese gall 10g, golden cypress 10g, folium artemisiae argyi 10g, kuh-seng 10g, frutus cnidii 10g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) take 1~6g95% of Tween 80 ethanol to dissolve, add 1~2g of flavoring essence, obtain second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 12
Chinese medicine preparation is made up of the Chinese medicine composition and pharmaceutically acceptable auxiliary material of embodiment 4.
Auxiliary material is：1~6g of Tween 80,1~2g of flavoring essence.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps：
1) pseudo-ginseng 30g, safflower 30g, Asian puccoon 35g, giant knotweed 35g, rheum officinale 30g, Radix Astragali 30g, rhizoma atractylodis 30g, the root bark of shaggy-fruited dittany are taken
30g, Chinese gall 30g, golden cypress 30g, folium artemisiae argyi 30g, kuh-seng 30g, frutus cnidii 30g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) take 1~6g95% of Tween 80 ethanol to dissolve, add 1~2g of flavoring essence, obtain second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 13
Chinese medicine preparation is made up of the Chinese medicine composition and pharmaceutically acceptable auxiliary material of embodiment 5.
Auxiliary material is：1~6g of Tween 80,1~2g of flavoring essence.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps：
1) pseudo-ginseng 40g, safflower 40g, Asian puccoon 45g, giant knotweed 45g, rheum officinale 40g, Radix Astragali 40g, rhizoma atractylodis 40g, the root bark of shaggy-fruited dittany are taken
40g, Chinese gall 40g, golden cypress 40g, folium artemisiae argyi 40g, kuh-seng 40g, frutus cnidii 40g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) take the ethanol of 1~6g of Tween 80 95% to dissolve, add 1~2g of flavoring essence, obtain second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 14
Chinese medicine preparation is made up of the Chinese medicine composition and pharmaceutically acceptable auxiliary material of embodiment 6.
Auxiliary material is：1~6g of Tween 80,1~2g of flavoring essence.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps：
1) pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed 23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, the root bark of shaggy-fruited dittany are taken
20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, frutus cnidii 20g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) borneol 5g, menthol 5g, 1~6g of Tween 80 mixing, the dissolving of 95% ethanol are taken, adds 1~2g of flavoring essence,
Obtain second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 15
Chinese medicine preparation is made up of the Chinese medicine composition and pharmaceutically acceptable auxiliary material of embodiment 7.
Auxiliary material is：1~6g of Tween 80,1~2g of flavoring essence.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps：
1) take pseudo-ginseng 5g, safflower 5g, Asian puccoon 10g, giant knotweed 10g, rheum officinale 5g, Radix Astragali 5g, rhizoma atractylodis 5g, root bark of shaggy-fruited dittany 5g,
Chinese gall 5g, golden cypress 5g, folium artemisiae argyi 5g, kuh-seng 5g, frutus cnidii 5g removal of impurities, crush, mixing, with 75% ethanol it is closed immersion 14 days,
Filtering, first material.
2) borneol 1g, menthol 1g, 1~6g of Tween 80 mixing, the dissolving of 95% ethanol are taken, adds 1~2g of flavoring essence,
Obtain second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 16
Chinese medicine preparation is made up of the Chinese medicine composition and pharmaceutically acceptable auxiliary material of embodiment 8.
Auxiliary material is：1~6g of Tween 80,1~2g of flavoring essence.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps：
1) pseudo-ginseng 20g, safflower 20g, Asian puccoon 23g, giant knotweed 23g, rheum officinale 20g, Radix Astragali 20g, rhizoma atractylodis 20g, the root bark of shaggy-fruited dittany are taken
20g, Chinese gall 20g, golden cypress 20g, folium artemisiae argyi 20g, kuh-seng 20g, frutus cnidii 20g are cleaned, crush, are mixed, be closed with 75% ethanol
Soak 14 days, filtering, first material.
2) borneol 5g, menthol 5g, 1~6g of Tween 80 mixing, the dissolving of 95% ethanol are taken, adds 1~2g of flavoring essence,
Obtain second material；
3) first material and the second material are mixed, adds 150~250g of water to stand more than 12h and takes supernatant, both
.
Embodiment 17
Chinese medicine preparation
Chinese medicine composition made from Example 1~8, customary adjuvant is added, mixed, conventionally, Chinese medicine is made
Paste；It is calculated in mass percent, Chinese medicine composition content described in the Chinese medicinal ointment is 70%.
Embodiment 18
Chinese medicine preparation
Chinese medicine composition made from Example 1~8, customary adjuvant is added, mixed, conventionally, Chinese medicine is made
Liniment；It is calculated in mass percent, Chinese medicine composition content described in the Chinese medicinal liniment is 50%.
Embodiment 19
Chinese medicine preparation
Chinese medicine composition made from Example 1~8, customary adjuvant is added, mixed, conventionally, Chinese medicine is made
Spray；It is calculated in mass percent, Chinese medicine composition content described in the Traditional Chinese medicinal spray is 20%.
Embodiment 20
Physical and chemical index detection is carried out to Chinese medicine composition prepared by embodiment 1~8, the results are shown in Table 1.
Table 1
| Project | Index |
| Lead (in terms of pb) mg/kg≤ | 1.5 |
| Arsenic (in terms of As) mg/kg≤ | 1.0 |
| Total mercury (in terms of Hg) mg/kg≤ | 0.3 |
Testing result shows, by Chinese medicine composition made from preparation method provided by the invention, reducing lead, total
The content of the heavy metals such as arsenic, total mercury, the content of lead is controlled within 1.5mg/kg, the content control of total arsenic 1.0mg/kg with
Interior, the content of total mercury is controlled within 0.3mg/kg, and human body is had no toxic side effect.
Embodiment 21
Acute toxicity maximum resistance test
According to embodiments of the present invention 9~19 Chinese medicine preparations prepared carry out acute toxicity maximum resistance test to animal, right
The day maximal tolerance dose of mouse administration is 420 times of adult's consumption per day, does not observe what the present invention was prepared under this dosage
The toxic reaction of preparation.Embodiment 22
Pharmacological evaluation
Experimental animal：Male Wistar Rats, 250 ± 20g of body weight.
Experimental group：The Chinese medicine preparation obtained in embodiment 9~16, difference label experimental group 1~8；
Positive control：MEIBAO SHIRUN SHAOSHANG GAO；
Therapeutic administratp：
220 rats are randomly divided into normal group 20, modeling group 200, rat back shaving (4cm × 4cm), modeling
8s is scalded in group rat shaving region with 100 DEG C of gauzes, continuous 3 times, causes deep II degree burn wound model.
Scald modeling group is randomly divided into model group, experimental group 1~8 and positive controls, each group 20.Respectively at modeling
The Chinese medicine preparation and positive drug MEIBAO SHIRUN SHAOSHANG GAO obtained in embodiment 9~16 is smeared at place, once a day, continuous 14 days, end
Rat is put to death after secondary administration, takes skin at back burns, carries out pathology detection.
Result of the test：Each group Ii _ i_iLLci _ i_ number of cases distribution results are shown in Table 2.
Table 2
| No inflammation | Mild inflammation | Light moderate inflammation | Moderate inflammation | Hyperphlogosis | |
| Normal group | 20 | 0 | 0 | 0 | 0 |
| Model group | 0 | 0 | 0 | 0 | 20 |
| Positive drug group | 0 | 0 | 7 | 7 | 6 |
| Experimental group 1 | 0 | 7 | 7 | 5 | 1 |
| Experimental group 2 | 0 | 5 | 8 | 5 | 2 |
| Experimental group 3 | 0 | 6 | 8 | 6 | 1 |
| Experimental group 4 | 0 | 6 | 7 | 5 | 1 |
| Experimental group 5 | 0 | 6 | 6 | 6 | 2 |
| Experimental group 6 | 0 | 8 | 7 | 5 | 0 |
| Experimental group 7 | 0 | 7 | 7 | 6 | 0 |
| Experimental group 8 | 0 | 7 | 8 | 5 | 0 |
As shown in Table 2, it is significantly higher than MEIBAO SHIRUN SHAOSHANG GAO using containing present invention offer Chinese medicine preparation alleviation scald
Therapeutic effect, Chinese medicine composition provided by the invention and the Chinese medicine preparation containing present invention offer Chinese medicine composition can be alleviated boiling hot
Wound, and significant effect.
Embodiment 23
Pharmacological evaluation
Pharmacological evaluation
Experimental animal：SD rats.
Experimental group：The Chinese medicine preparation obtained in embodiment 9~16, difference label experimental group A~H；
Positive controls：Sulfadiazine Silver Cream；
Blank control group：Purified water.
Therapeutic administratp：
SD rats 100 are chosen, are randomly divided into 10 groups, i.e. experimental group A~H, positive controls (Sulfadiazine Silver Cream)
And blank control group.24h sloughs the hair of mouse back with the vulcanized sodium of hair remover 10% before experiment, after etherization, is put
(2cm × 2cm apertures are cut on cardboard in advance) on millboard, and make depilation position face aperture.0.3mL is taken to mix with suction pipe
Fuel is coated in exposed place, and ignition 20s causes rat dorsum skin eschar burn model.Burnt degree naked eyes are seen, outside early stage skin
See whiter or pale brown.
Smear and be administered in burned part respectively after the 0.5h that burns, continuous 8h, keep surface of a wound moistening, later daily administration 2
It is secondary, continuous 20d.All fall de-, new skin with incrustation to grow for healing standard, observe wound healing time and healing animal number.
Result of the test：It the results are shown in Table 3.
Table 3
As shown in Table 3, it is significantly higher than Sulfadiazine Silver Cream using containing present invention offer Chinese medicine preparation alleviation burn
Therapeutic effect, Chinese medicine composition provided by the invention and the Chinese medicine preparation containing present invention offer Chinese medicine composition can alleviate burning
Wound, and significant effect.
Embodiment 24
Chinese medicine composition provided by the invention, Chinese medicine preparation treatment example
Case 1：
Name：Mr. Wang, sex：Man, age：48 years old, with sore stubborn dermatitis, therebetween once with multi-medicament, physical treatment, effect
Fruit is undesirable, and the Chinese medicinal ointment that the application embodiment of the present invention 17 provides is in affected part, daily 3~4 times, per minor tick 3~4 hours,
Cure within 15~20 days.
Case 2：
Name：Lee, sex：Female, age：45 years old, with sore stubborn dermatitis, therebetween once with multi-medicament, physical treatment, effect
Fruit is undesirable, and the Chinese medicinal ointment that the application embodiment of the present invention 17 provides, Chinese medicinal ointment is in affected part, daily 3~4 times, per minor tick 3
Remission after~4 hours, 6~8 days, non-evident sympton after 15~20 days.
Case 3：
Name：Xiong, sex：Female, age：54 years old, with pruitus caused by dermatitis and eczema, therebetween once with a variety of medicines
Thing, physical treatment, effect is undesirable, using the Chinese medicinal ointment that the embodiment of the present invention 17 provides in affected part, daily 3~4 times, every time
Interval remission after 3~4 hours, 6~8 days, non-evident sympton after 15~20 days.
Case 4：
Name：Zhao, sex：Man, age：57 years old, with pruitus caused by bite by mosquitos, therebetween once with a variety of medicines
Thing, physical treatment, effect is undesirable, using the liniment that the embodiment of the present invention 18 provides in affected part, daily 3~4 times, and per minor tick
Remission after 3~4 hours, 6~8 days, non-evident sympton after 15~20 days.
Case 5：
Name：Lee, sex：Man, age：57 years old, pruitus caused by acne tinea pedis, use the embodiment of the present invention 19
Traditional Chinese medicinal spray is in affected part, daily 3~4 times, per minor tick remission after 3~4 hours, 7 days, without obvious disease after 15~20 days
Shape.
Case 6：
Name：Chen, sex：Female, age：37 years old, with traumatism and bleeding caused by superficial incised injury, using of the invention real
The Chinese medicinal ointment of example 17 is applied in affected part, daily 3~4 times, per minor tick remission after 3~4 hours, 7 days, without bright after 15~20 days
Aobvious symptom.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition, it is characterised in that in parts by weight, the traditional Chinese medicine composite includes：Pseudo-ginseng 5~40
Part, 5~40 parts of safflower, 10~45 parts of Asian puccoon, 10~45 parts of giant knotweed, 5~40 parts of rheum officinale, 5~40 parts of the Radix Astragali, rhizoma atractylodis 5~40
Part, 5~40 parts of the root bark of shaggy-fruited dittany, 5~40 parts of Chinese gall, 5~40 parts of golden cypress, 5~40 parts of folium artemisiae argyi, 5~40 parts of kuh-seng, frutus cnidii 5~
40 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that in parts by weight, the traditional Chinese medicine composite
Including：10~30 parts of pseudo-ginseng, 10~30 parts of safflower, 15~35 parts of Asian puccoon, 15~35 parts of giant knotweed, 10~30 parts of rheum officinale, the Radix Astragali
10~30 parts, 10~30 parts of rhizoma atractylodis, 10~30 parts of the root bark of shaggy-fruited dittany, 10~30 parts of Chinese gall, 10~30 parts of golden cypress, folium artemisiae argyi 10~30
Part, 10~30 parts of kuh-seng, 10~30 parts of frutus cnidii.
3. Chinese medicine composition according to claim 1, it is characterised in that in parts by weight, the traditional Chinese medicine composite
Also include：1~5 part of borneol, 1~5 part of menthol.
4. Chinese medicine composition according to claim 1, it is characterised in that in parts by weight, the traditional Chinese medicine composite
Also include：3 parts of borneol, 3 parts of menthol.
5. a kind of preparation method of Chinese medicine composition, it is characterised in that comprise the following steps：In parts by weight, pseudo-ginseng 5~40 is taken
Part, 5~40 parts of safflower, 10~45 parts of Asian puccoon, 10~45 parts of giant knotweed, 5~40 parts of rheum officinale, 5~40 parts of the Radix Astragali, rhizoma atractylodis 5~40
Part, 5~40 parts of the root bark of shaggy-fruited dittany, 5~40 parts of Chinese gall, 5~40 parts of golden cypress, 5~40 parts of folium artemisiae argyi, 5~40 parts of kuh-seng, frutus cnidii 5~
40 parts of crushing, mixing, solvent extraction, filterings, both.
6. Chinese medicine composition preparation method according to claim 5, it is characterised in that the step is specially：
1) 5~40 parts of pseudo-ginseng, 5~40 parts of safflower, 10~45 parts of Asian puccoon, 10~45 parts of giant knotweed, 5~40 parts of rheum officinale, the Radix Astragali 5 are taken
~40 parts, 5~40 parts of rhizoma atractylodis, 5~40 parts of the root bark of shaggy-fruited dittany, 5~40 parts of Chinese gall, 5~40 parts of golden cypress, 5~40 parts of folium artemisiae argyi, kuh-seng 5
~40 parts, frutus cnidii 5~40 parts of crushing, mixing, solvent extraction, filterings, obtain first material；
2) 1~5 part of borneol, 1~5 part of mixing of menthol, dissolving are taken, obtains second material；
3) first material and the second material are mixed, both.
7. the preparation side described in Chinese medicine composition or any one of claim 5~6 according to any one of claims 1 to 3
Chinese medicine composition prepared by method prepare alleviate burn and scald, sore stubborn dermatitis, traumatism and bleeding, pruitus medicine in should
With.
8. a kind of Chinese medicine preparation, it is characterised in that the Chinese medicine preparation is as the Chinese traditional medicine composition described in any one of Claims 1 to 4
Thing and pharmaceutically acceptable auxiliary material are made.
9. Chinese medicine preparation according to claim 8, it is characterised in that the formulation of the Chinese medicine preparation be paste, liniment or
Spray.
10. a kind of preparation method of Chinese medicine preparation, it is characterised in that comprise the following steps：
1) 5~40 parts of pseudo-ginseng, 5~40 parts of safflower, 10~45 parts of Asian puccoon, 10~45 parts of giant knotweed, rheum officinale 5 in parts by weight, are taken
~40 parts, 5~40 parts of the Radix Astragali, 5~40 parts of rhizoma atractylodis, 5~40 parts of the root bark of shaggy-fruited dittany, 5~40 parts of Chinese gall, 5~40 parts of golden cypress, folium artemisiae argyi 5
~40 parts, 5~40 parts of kuh-seng, frutus cnidii 5~40 parts of crushing, mixing, solvent extraction, filterings, both；
2) 1~5 part of borneol, 1~5 part of menthol, 1~6 part of mixing of Tween 80, dissolving are taken, 1~2 part of flavoring essence is added, obtains
To second material；
3) first material and the second material are mixed, both.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519335A (en) * | 2017-10-10 | 2017-12-29 | 金得成 | A kind of liquid medicine for treating empyrosis |
| CN113350437A (en) * | 2021-05-24 | 2021-09-07 | 平顶山宙斯生物科技有限公司 | Traditional Chinese medicine gauze for rapid healing of burn and scald wound surfaces and preparation method thereof |
| CN114533800A (en) * | 2022-02-19 | 2022-05-27 | 甘肃中医药大学 | Traditional Chinese medicine composition with antibacterial function and method for preparing hand cream by using same |
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| CN104873774A (en) * | 2015-05-14 | 2015-09-02 | 苏桂枝 | Ointment for treating burns and scalds as well as preparation and application methods of ointment |
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- 2017-10-17 CN CN201710967265.2A patent/CN107648393A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104873774A (en) * | 2015-05-14 | 2015-09-02 | 苏桂枝 | Ointment for treating burns and scalds as well as preparation and application methods of ointment |
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| 杨晓国等: "三色膏治疗Ⅱ度烧伤", 《中国乡村医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519335A (en) * | 2017-10-10 | 2017-12-29 | 金得成 | A kind of liquid medicine for treating empyrosis |
| CN113350437A (en) * | 2021-05-24 | 2021-09-07 | 平顶山宙斯生物科技有限公司 | Traditional Chinese medicine gauze for rapid healing of burn and scald wound surfaces and preparation method thereof |
| CN114533800A (en) * | 2022-02-19 | 2022-05-27 | 甘肃中医药大学 | Traditional Chinese medicine composition with antibacterial function and method for preparing hand cream by using same |
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