CN107648352A - 一种治疗娃娃鱼赤皮病的中药提取液及其制备方法 - Google Patents
一种治疗娃娃鱼赤皮病的中药提取液及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗娃娃鱼赤皮病的中药提取液,其是由下列质量份配比的原料药制成:槐米100份、草头50‑80份、石决明190‑220份、蒲公英180‑220份、没药180‑210份、艾草80‑110份、槐花130‑170份、栀子185‑215份、细辛105‑135份、枳壳210‑245份、牙皂105‑140份、地瓜叶235‑260份、鸡屎藤120‑150份、肿节风100‑200份。该药物中各原料配伍不存在配伍禁忌,能明显降低娃娃鱼赤皮病的发生率,并且无毒副作用,使用安全,无有害药物残留。
Description
技术领域
本发明属于娃娃鱼养殖技术领域,具体涉及一种治疗娃娃鱼赤皮病的中药提取液及其制备方法。
背景技术
大鲵隶属隐腮鲵科,大鲵属,是世界上现存最大的也是最珍贵的两栖动物;它的叫声像婴儿的哭声,因此人们又叫它“娃娃鱼”;娃娃鱼俗称“大山椒鱼”,源于其身有山椒味道;娃娃鱼是代表鱼类和爬行类的过渡类型,有古老“活化石”之称,同时其肉质洁白鲜嫩,肥而不腻,味道特鲜,含有丰富的营养物质,被誉为水中“活人参”。
野生娃娃鱼资源已濒临灭绝,开展人工规模养殖是恢复娃娃鱼自然资源,满足社会需求的必由之路;在养殖的过程娃娃鱼容易发生赤皮病,发病的娃娃鱼全身肿胀,呈充血发炎的红斑块和化脓性溃疡;病鱼体表常出现不规则的红色肿块,发病初期于红色肿块中央部位有米粒大小的浅黄色脓包,并逐渐向周周皮肤组织扩散增大;当脓包穿破后,便形成较大的溃烂病灶;解剖检查,肝脏肿大有出血点,肠糜烂,腹水增多。
现有技术中一般采用如下方法防治娃娃鱼赤皮病:1)首先在体表溃疡处涂抹氯霉素软膏,同时肌肉注射庆大霉素,连续注射七天,每天每公斤娃娃鱼体重注射15毫克庆大霉素,治愈率达93%;2)链霉素、氟哌酸有疗效;3)用增效联胺与卡那霉素内服,每公斤娃娃鱼体重用增效联胺50毫克埋入鱼块中投饲,连续5天;同时按每公斤娃娃鱼体重肌肉注射1/3亳升卡那霉素,连续5天;这些药物均为西药,容易造成药物依赖,或者影响娃娃鱼肉质,因此有必要开发一种治疗娃娃鱼赤皮病的中药提取液。
发明内容
本发明的目的在于克服现有技术的不足,提供一种治疗娃娃鱼赤皮病的中药提取液,药物中各原料配伍不存在配伍禁忌,能明显降低娃娃鱼赤皮病的发生率,对娃娃鱼赤皮病有很好的预防和治疗作用,并且无毒副作用,使用安全,无有害药物残留。
本发明解决其技术问题所采用的技术方案是:
本发明的技术方案是:一种治疗娃娃鱼赤皮病的中药提取液,其是由下列质量份配比的原料药制成:槐米100份、草头50-80份、石决明190-220份、蒲公英180-220份、没药180-210份、艾草80-110份、槐花130-170份、栀子185-215份、细辛105-135份、枳壳210-245份、牙皂105-140份、地瓜叶235-260份、鸡屎藤120-150份、肿节风100-200份。
其进一步的优选质量份配比为:槐米100份、草头50-75份、石决明190-215份、蒲公英190-215份、没药185-210份、艾草80-105份、槐花130-160份、栀子185-210份、细辛105-130份、枳壳210-240份、牙皂110-140份、地瓜叶240-260份、鸡屎藤125-150份、肿节风110-200份。
其进一步的优选质量份配比为:槐米100份、草头50-70份、石决明190-210份、蒲公英190-210份、没药190-210份、艾草90-105份、槐花140-160份、栀子190-210份、细辛110-130份、枳壳220-240份、牙皂120-140份、地瓜叶245-260份、鸡屎藤130-150份、肿节风120-190份。
其进一步的优选质量份配比为:槐米100份、草头55-70份、石决明190-205份、蒲公英195-210份、没药190-205份、艾草95-105份、槐花140-155份、栀子190-205份、细辛110-125份、枳壳220-235份、牙皂120-135份、地瓜叶245-255份、鸡屎藤135-150份、肿节风120-180份。
其进一步的优选质量份配比为:槐米100份、草头60-70份、石决明190-200份、蒲公英200-210份、没药190-200份、艾草100-105份、槐花150-155份、栀子200-205份、细辛110-120份、枳壳220-230份、牙皂130-135份、地瓜叶245-250份、鸡屎藤140-150份、肿节风130-150份。
其进一步的优选质量份配比为:槐米100份、草头60份、石决明200份、蒲公英200份、没药200份、艾草100份、槐花150份、栀子200份、细辛120份、枳壳230份、牙皂130份、地瓜叶250份、鸡屎藤140份、肿节风150份。
本发明用到的主要原料药说明如下:
槐米:槐米广义是为豆科植物槐(Sophora japonica L.)的干燥花蕾及花;槐米主产于河南、山东、山西、陕西、安徽、河北、江苏、贵州等地,近年来宁夏、甘肃等地也已有规模,越南也有大面积的栽种;夏季花未开放时采收其花蕾,称为“槐米”;花开放时采收,称为“槐花”;采收后除去花序的枝、梗及杂质,及时干燥,生用、炒用或炒炭用;本发明的槐米为金槐槐米。
石决明:为鲍科动物杂色鲍、皱纹盘鲍、耳鲍、羊鲍等的贝壳;又名真珠母(《雷公炮炙论》),鳆鱼甲(《本草经集注》),九孔螺(《日华子本草》),千里光(《纲目》),真海决、海决明、关海决、鲍鱼壳、九孔草头(《药材学》),鲍鱼皮(《山东中药手册》),金蛤蜊皮(《山东中草药》);有平肝清热,明目去翳的功效;本品为常用中药,"名医别录"列为上品;今市售品分为光底海决、毛底海决和大海决三种;光底海决原动物为九孔鲍,毛底海决原动物为盘大鲍,大海决的原动物为羊鲍;其它名称 真珠母,鳆鱼甲,九孔螺,千里光,鲍鱼皮,金蛤蜊皮。
草头:是上海、太仓、常熟等地的人对金花菜的称呼,金花菜,原名南苜蔌MedicagohispidaGaertn 有叶三齿,如倒心形,先端稍圆或凹入上部有锯齿,叶的表面呈浓绿色,茎梗极短,主根长,多分枝;茎通常直立,近无毛,高30-100厘米;复叶有3小叶,小叶倒卵形或倒披针形,长1-2厘米,宽约0.5厘米,顶端圆,中肋稍凸出,上半部叶有锯齿,基部狭楔形;托叶狭披针形,全缘;总状花序腋生,花8-25;荚果螺旋形,无刺,顶端有尖曝咀;在江浙两省生产特多;草头为豆科植物,经常食用石决明素可平衡人体的酸碱值。
蒲公英:蒲公英别名黄花地丁、婆婆丁、华花郎等;菊科多年生草本植物;头状花序,种子上有白色冠毛结成的绒球,花开后随风飘到新的地方孕育新生命。
没药:中药名,为橄榄科植物地丁树Commiphora myrrha Engl.或哈地丁树Commiphora molmol Engl.的干燥树脂;分为天然没药和胶质没药;分布于索马里、埃塞俄比亚及阿拉伯半岛南部等地;具有散瘀定痛,消肿生肌之功效;常用于胸痹心痛,胃脘疼痛,痛经经闭,产后瘀阻,癥瘕腹痛,风湿痹痛,跌打损伤,痈肿疮疡等病症的治疗。
艾草:多年生草本或略成半灌木状,植株有浓烈香气;茎单生或少数,褐色或灰黄褐色,基部稍木质化,上部萆质,并有少数短的分枝,叶厚纸质,上面被灰白色短柔毛,基部通常无假托叶或极小的假托叶;上部叶与苞片叶羽状半裂、头状花序椭圆形,花冠管状或高脚杯状,外面有腺点,花药狭线形,花柱与花冠近等长或略长于花冠;瘦果长卵形或长圆形;花果期9-10月;全草入药,有温经、去湿、散寒、止血、消炎、平喘、止咳、安胎、抗过敏等作用;艾叶晒干捣碎得“艾绒”,制艾条供艾灸用,又可作“印泥”的原料。
槐花:槐花,又名洋槐花,广义的洋槐花指豆科植物的花及花蕾,但一般将开放的花朵称为“槐花”,也称“槐蕊”,花蕾则称为“槐米”;常植于屋边、路边,中国各地普遍栽培,主要在北方,以黄土高原和华北平原为多,一般在每年4、5月开花,花期一般为10-15天左右。
栀子:别名黄栀子、山栀、白蟾、栀子花,是茜草科植物栀子的果实;属茜草科、栀子属,常绿灌木;根、叶、果实均可入药,有泻火除烦,清热利尿,凉血解毒之功效;功效主治:清肺止咳,凉血止血,泻火,主治肺热咳嗽,咯痰,肿毒,治热病虚烦不眠,黄疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛;《中药大辞典》中记载:栀子,异名:木丹(《本经》),鲜支(《上林赋》),卮子(《汉书》孟康注),越桃(《别录》),支子(《本草经集注》),山栀子(《药性论》),枝子(《新修本草》),小危子(《本草原始》),黄荑子(《闽东本草》),黄栀子(《江苏药材志》),黄栀、山黄栀、山栀(《浙江药用植物志》);为茜草科栀子属植物栀子的果实。
细辛;别名:华细辛、盆草细辛,马兜铃科、细辛属多年生草本;细辛作为药用植物,始载秦汉《神农本草经》,《神农本草经》将其列为上品;辽细辛根细、色灰黄、叶色绿,味辛辣麻舌;性温,有小毒;归心、肺、肾经;有祛风,散寒,温肺、行水,开窍的作用;治风寒头痛,鼻渊,齿痛,痰饮咳逆,风湿痹痛;此外,细辛还具有抗炎免疫、 细辛 局部麻醉、提高新陈代谢、抗菌作用,亦可用于肿瘤患者化疗和放疗所致的白细胞减少。
枳壳: 药用来源为芸香科植物酸橙及其栽培变种的干燥未成熟果实;7月果皮尚绿时采收,自中部横切为两半,晒干或低温干燥;枳壳性苦、辛、酸、温,具有理气宽中、行滞消胀的功效,主治胸胁气滞,胀满疼痛,食积不化,痰饮内停;胃下垂,脱肛,子官脱垂等病症。
牙皂:又称:猪牙皂;是豆科植物皂荚植株受伤后所结的小型果实,弯曲成月牙形;形扁长者,称为大皂荚(即皂荚);含三萜类皂甙、鞣质、蜡醇、廿九烷、豆甾醇等;有祛痰、催吐、致泻等作用。
地瓜叶:又叫红薯叶;即红薯生长过程中的茎上的叶子;红薯叶有很多用途,比如有提高免疫力,保护视力,延缓衰老,解毒等作用;一般食用的是秋天红薯成熟后地上秧茎顶端的嫩叶;红薯叶有提高免疫力、止血、降糖、解毒、防治夜盲症促进新陈代谢、通便利尿、升血小板、预防动脉硬化、阻止细胞癌变、催乳解毒等保健功能;红薯叶可使肌肤变光滑,经常食用有预防便秘、保护视力的作用,还能保持皮肤细腻、延缓衰老。
鸡屎藤:鸡屎藤一般指鸡矢藤,为茜草科植物鸡矢藤的全草,夏季采收全草,晒干;其味甘、微苦,性平;具有祛风利湿,止痛解毒,消食化积,活血消肿之功效。用于风湿筋骨痛,跌打损伤,外伤性疼痛,肝胆及胃肠绞痛,消化不良,小儿疳积,支气管炎;外用于皮炎,湿疹及疮疡肿毒。
肿节风:为金粟兰科植物草珊瑚的干燥全株;夏、秋二季采收,除去杂质,晒干;别名:接骨金粟兰、九节茶、九节花、九节风、竹节茶、接骨莲、观音茶、接骨木、九节风、驳节茶、鸭脚节、山牛膝、珍珠兰、九节草、野靛、学士茶、接骨丹、接骨草、铜脚灵仙、九节 兰、节骨茶、接骨莲、竹茶;功能主治抗菌消炎凉血清热解毒,祛风通络,活血散结;用于肺炎、阑尾炎、蜂窝组织炎属热毒壅盛证候者;以及风湿痹痛、跌扑损伤、肿瘤的辅助治疗。
本发明的药物中各原料配伍不存在配伍禁忌,能明显降低娃娃鱼赤皮病的发生率,对娃娃鱼赤皮病有很好的预防和治疗作用,并且无毒副作用,使用安全,无有害药物残留。
本发明的另一目的是提供一种上述药物的制备方法,其工艺简单,其原料药常见、便宜。
本发明药物的制备方法如下:
第一步:按配方比例计算出批次生产的原料重量;
第二步: 将计算出批次生产的原料放置于搅拌容器中,用水浸泡3-5小时,其中水的用量为中药总重的5-10倍,温火加温烧至沸腾,熬15-20分钟,然后保温3小时后,再温火加温烧至沸腾,熬25-30分钟;
第三步:进行离心过滤,过滤液经过2-3小时沉淀后,第二次离心过滤;过滤液即为本发明治疗娃娃鱼赤皮病的中药提取液。
本发明的药物使用方法:用水稀释10倍在体表涂抹。
为了更清楚地说明本发明,列举以下实施例,但其对发明的范围无任何限制。
具体实施方式
实施例1
称取槐米100g,草头60g,石决明200g,蒲公英200g,没药200g,艾草100g,槐花150g,栀子200g,细辛120g,枳壳230g,牙皂130g,地瓜叶150g,鸡屎藤140g、肿节风150份,这些原料成分均为经过晒干后的质量。
第一步:按配方比例计算出批次生产的原料重量;
第二步: 将计算出批次生产的原料放置于搅拌容器中,用水浸泡4小时,其中水的用量为中药总重的10倍;温火加温烧至沸腾,熬20分钟,然后保温3小时后,再温火加温烧至沸腾,熬30分钟;
第三步:进行离心过滤,过滤液经过2小时沉淀后,第二次离心过滤;过滤液即为本发明治疗娃娃鱼赤皮病的药物。
实施例2-12
实施例2-12除了原料质量配比与实施例1不同外,其原料种类和制备工艺步骤及使用方法与实施例1 相同,对比例1是在实施例1的基础上去掉了没药,对比例2是在实施例1的基础上去掉了槐花,实施例1-12、对比例1-2所使用的原料及质量如下面的表1所示,下面的表1示出了实施例1-12、对比例1-2所使用的原料及质量。
表1,(单位克)
。
临床试验:
(1)实验动物
选择 300只患有赤皮病的娃娃鱼成鱼,食欲减退,不愿活动。
(2)实验方法
随机分组,共分15个组,每组20 只,其中14组为实验组,分别用水稀释10倍在体表涂抹,每天1次,连续10天;另一组为对照组,使用现有技术肌肉注射庆大霉素;治疗10天之后,观察并做好记录;具体见表2。
(3) 治疗标准及观察方法
治愈:赤皮病痊愈;
有效:赤皮病得到有效缓解,有很大的缓解;
无效:赤皮病没有得到有效缓解。
表2
。
由此可知,本发明实施例的治疗效果明显优于对比例和对照组;并且1个月后,实验组为0复发,而对比组有5只复发。
所以本发明不局限于作为治疗娃娃鱼赤皮病的中药提取液,只要是原料配方与本发明相同或者等同的药物就落在本发明的保护范围之内;将与本发明的治疗娃娃鱼赤皮病的中药提取液相同配方的原料制成任何一种中药制剂也落在本发明的保护范围之内,即只要原料配方与本发明相同的药物就落在本发明的保护范围之内。
Claims (7)
1.一种治疗娃娃鱼赤皮病的中药提取液,其特征在于,由下列质量份配比的原料药制成:槐米100份、草头50-80份、石决明190-220份、蒲公英180-220份、没药180-210份、艾草80-110份、槐花130-170份、栀子185-215份、细辛105-135份、枳壳210-245份、牙皂105-140份、地瓜叶235-260份、鸡屎藤120-150份、肿节风100-200份。
2.根据权利要求1所述的治疗娃娃鱼赤皮病的中药提取液,其特征在于:槐米100份、草头50-75份、石决明190-215份、蒲公英190-215份、没药185-210份、艾草80-105份、槐花130-160份、栀子185-210份、细辛105-130份、枳壳210-240份、牙皂110-140份、地瓜叶240-260份、鸡屎藤125-150份、肿节风110-200份。
3.根据权利要求1所述的治疗娃娃鱼赤皮病的中药提取液,其特征在于:槐米100份、草头50-70份、石决明190-210份、蒲公英190-210份、没药190-210份、艾草90-105份、槐花140-160份、栀子190-210份、细辛110-130份、枳壳220-240份、牙皂120-140份、地瓜叶245-260份、鸡屎藤130-150份、肿节风120-190份。
4.根据权利要求1所述的治疗娃娃鱼赤皮病的中药提取液,其特征在于:槐米100份、草头55-70份、石决明190-205份、蒲公英195-210份、没药190-205份、艾草95-105份、槐花240-255份、栀子190-205份、细辛110-125份、枳壳220-235份、牙皂120-135份、地瓜叶145-155份、鸡屎藤135-150份、肿节风120-180份。
5.根据权利要求1所述的治疗娃娃鱼赤皮病的中药提取液,其特征在于:槐米100份、草头60-70份、石决明190-200份、蒲公英200-210份、没药190-200份、艾草100-105份、槐花150-155份、栀子200-205份、细辛110-120份、枳壳220-230份、牙皂130-135份、地瓜叶245-250份、鸡屎藤140-150份、肿节风130-150份。
6.根据权利要求1所述的治疗娃娃鱼赤皮病的中药提取液,其特征在于:槐米100份、草头60份、石决明200份、蒲公英200份、没药200份、艾草100份、槐花150份、栀子200份、细辛120份、枳壳230份、牙皂130份、地瓜叶250份、鸡屎藤140份。
7.根据权利要求1所述治疗娃娃鱼赤皮病的中药提取液的制备方法,其特征在于包括如下步骤:
第一步:按配方比例计算出批次生产的原料重量;
第二步: 将计算出批次生产的原料药放置于搅拌容器中,用水浸泡3-5小时,其中水的用量为中药总重的5-10倍,温火加温烧至沸腾,熬15-20分钟,然后保温3小时后,再温火加温烧至沸腾,熬25-30分钟;
第三步:进行离心过滤,过滤液经过2-3小时沉淀后,第二次离心过滤;过滤液即为治疗娃娃鱼赤皮病的中药提取液。
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