CN107647852A - A kind of System and method for being imaged in bio-tissue - Google Patents
A kind of System and method for being imaged in bio-tissue Download PDFInfo
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- CN107647852A CN107647852A CN201711138938.XA CN201711138938A CN107647852A CN 107647852 A CN107647852 A CN 107647852A CN 201711138938 A CN201711138938 A CN 201711138938A CN 107647852 A CN107647852 A CN 107647852A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0097—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying acoustic waves and detecting light, i.e. acoustooptic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
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Abstract
The present invention provides a kind of System and method for being imaged in bio-tissue, and its system includes：Ultrasound unit, for output ultrasonic wave and produce the optical signal of sonoluminescence, quantum dot, for optical signal caused by the sonoluminescence to be converted into infrared signal, the quantum dot is embedded in inside bio-tissue in advance, detection unit, for being detected and being recorded to infrared signal, complete three-dimensional imaging；The present invention triggers emperor's body organization internal to produce the optical signal of sonoluminescence by ultrasonic probe, and the optical signal is converted into infrared light, by gathering infrared light, completes the three-dimensional imaging to organization internal；The present invention while ensureing to fathom, can reach higher resolution ratio when to bio-tissue internal imaging.
Description
Technical field
The present invention relates to medical device fields, more particularly to a kind of System and method for being imaged in bio-tissue.
Background technology
Bio-tissue, therefore can not direct imaging to its inside due to its opaque and inhomogenous property.Spread light
Learn tomography and also known as diffuse optical tomography (Diffuse Optical tomography or Optical
Diffusion Tomography, DOT/ODT), can be by developing highly sensitive near-infrared photon detecting instrument and based on life
The Image Reconstruction Technology of thing tissue photon transport model, spread the time of light from excitation lower surface, be spatially and spectrally distributed
The distributed in three dimensions of inverting organizer internal opticses characterisitic parameter in metrical information, and it is allowed to related to the physiological status of the tissue
Connection, and X ray, ultrasound are compared with conventional image forming process such as magnetic resonance, in the sensitivity changed to function of organization, specificity and are moved
The state property and security used, portability and cost performance etc. have obvious advantage.
At present, prior art means have fluorescence diffusing reflection tomography (Fluorescence diffuse optical
Tomography, FDOT).The advantages of this technology is that the organization internal as deep as several centimeters can be imaged, but this method
Resolution ratio it is again not satisfactory enough, therefore, need a kind of new technological means badly, the situation of depth and resolution ratio can ensured
Under, organization internal is imaged.
The content of the invention
In view of the above the shortcomings that prior art, the present invention provides a kind of system being imaged in bio-tissue and side
Method, to solve above-mentioned technical problem.
The system provided by the invention being imaged in bio-tissue, including：
Ultrasound unit, for output ultrasonic wave and produce the optical signal of sonoluminescence；
Quantum dot, for optical signal caused by the sonoluminescence to be converted into infrared signal, the quantum dot is set in advance
It is placed in inside bio-tissue；
Detection unit, for being detected and being recorded to infrared signal, complete three-dimensional imaging.
Further, in addition to：
Collecting unit, for gathering infrared signal；
The collecting unit includes optical fiber, lens group and photomultiplier, the output end of the optical fiber and lens group it is defeated
Enter end connection, light is focused at the receiving plane of photomultiplier, the photoelectricity times by optical fiber and lens group by the infrared signal
The input of the output end and detection unit that increase pipe connects.
Further, in addition to：
Signal generator, for sending control signal to ultrasound unit and detection unit；
The output end of the signal generator is connected with the input and detection unit of power amplifier unit respectively, the power amplifier list
The output end of member and the input of ultrasound unit connect；
Power amplifier unit, for control signal to be amplified；
The output end of the power amplifier unit and the input of ultrasound unit connect.
Further, the lens group includes optical filter, for being filtered to veiling glare in infrared signal.
Further, the ultrasound unit is aggregation ultrasonic probe, and the ultrasound unit is set according to signal generator
Control parameter be operated, the control parameter comprise at least signal frequency and dutycycle
The present invention also provides a kind of method being imaged in bio-tissue, including：
Quantum dot is pre-set inside bio-tissue；
Output ultrasonic wave simultaneously triggers the optical signal that sonoluminescence is produced in bio-tissue；
Optical signal caused by the sonoluminescence is converted to by infrared signal by quantum dot；
Infrared signal is detected and recorded, completes three-dimensional imaging.
Further, infrared signal is focused to the receiving plane of photomultiplier by optical fiber and lens group, passes through photoelectricity times
Increasing pipe, which is amplified to infrared signal and inputted to detection unit, to be detected.
Further, while to power amplifier unit and detection unit synchronous triggering signal is sent, will be triggered and believed by power amplifier unit
Number it is amplified and triggers ultrasound unit output ultrasonic wave, triggers the optical signal that sonoluminescence is produced inside bio-tissue,
And detection is synchronized by detection unit.
Further, filtration treatment is carried out to infrared signal, filters out the veiling glare in infrared signal.
Further, output different frequency and the high-frequency ultrasonic of dutycycle are triggered according to default control parameter, passes through shifting
The position of dynamic ultrasound unit, completes the three-dimensional imaging inside bio-tissue.
Beneficial effects of the present invention：The System and method for being imaged in bio-tissue in the present invention, visited by ultrasound
Head triggers emperor's body organization internal to produce the optical signal of sonoluminescence, and the optical signal is converted into infrared light, infrared by gathering
Light, complete the three-dimensional imaging to organization internal；The present invention can ensure to fathom when to bio-tissue internal imaging
While, higher resolution ratio can be reached.
Brief description of the drawings
Fig. 1 is the system structure diagram being imaged in bio-tissue of the embodiment of the present invention.
Fig. 2 is the method flow schematic diagram being imaged in bio-tissue of the embodiment of the present invention.
Embodiment
Illustrate embodiments of the present invention below by way of specific instantiation, those skilled in the art can be by this specification
Disclosed content understands other advantages and effect of the present invention easily.The present invention can also pass through specific realities different in addition
The mode of applying is embodied or practiced, the various details in this specification can also be based on different viewpoints with application, without departing from
Various modifications or alterations are carried out under the spirit of the present invention.It should be noted that in the case where not conflicting, following examples and implementation
Feature in example can be mutually combined.
It should be noted that the diagram provided in following examples only illustrates the basic structure of the present invention in a schematic way
Think, only show the component relevant with the present invention in schema then rather than according to component count, shape and the size during actual implement
Draw, kenel, quantity and the ratio of each component can be a kind of random change during its actual implementation, and its assembly layout kenel
It is likely more complexity.
As shown in figure 1, the system being imaged in bio-tissue in the present embodiment, including：
Ultrasound unit, for output ultrasonic wave and produce the optical signal of sonoluminescence；
Quantum dot, for optical signal caused by the sonoluminescence to be converted into infrared signal, the quantum dot is embedded in advance
Inside bio-tissue；
Detection unit, for being detected and being recorded to infrared signal, complete three-dimensional imaging.
As shown in figure 1, in the present embodiment, for bio-tissue using imitative body, it is with bio-tissue property to imitate body
Model, an internal pre-buried pipeline for imitating blood vessel simultaneously inject quantum dot (quantum dots, QD), this implementation inside pipeline
The effect of quantum dot in example is that the optical signal of sonoluminescence is converted into near infrared signal, and this kind of optical signal is not easy in organism
Dissipate, can be detected by the detector outside tissue in tissue, pass through sonoluminescence light caused by ultrasound unit aggregation ultrasound
Signal can be converted near infrared light (NIR) in vivo, and the wavelength of this light is longer, the ultrasonic wave list in the present embodiment
Member, focused ultrasonic transducer can be used, by the position of mobile focused ultrasonic transducer, complete the process to organization internal imaging.
Quantum dot has good water solubility and biocompatibility, further, since the particle very little (nano-scale) of quantum dot, is dissolved in water
When can be by the capillary of organism, and blood vessel almost spreads over the major organs and tissue of organism, therefore, this reality
Apply and inject quantum dot in example by the way of by intravascular injection, naturally it is also possible to be pre-set at organism using other modes
In tissue, its purpose is to eventually through the near infrared light of collection quantum dot come complete inside bio-tissue it is three-dimensional into
Picture.
In the present embodiment, in addition to：Collecting unit, for gathering infrared signal；Collecting unit mainly include optical fiber, thoroughly
The input of microscope group and photomultiplier, the output end of the optical fiber and lens group connects, the infrared signal by optical fiber and
Light is focused at the receiving plane of photomultiplier by lens group, and the output end of the photomultiplier and the input of detection unit connect
Connect.NIR can pass through imitative body tissue, be focused at by optical fiber and lens group on photomultiplier (PMT) receiving plane.Optical fiber leads to
This mode of tension adhesion body surface is obtained with optical signal, and photomultiplier is examined optical signal amplification by detection means
Survey and record, it is preferable that in order to ensure the intensity of the signal collected, optical fiber and ultrasound unit in the present embodiment keep synchronous
It is mobile.Wherein, optical filter F1 is included in lens group, for filtering out the veiling glare in addition to infrared signal.Focused on by mobile
The position of ultrasonic probe, complete the process of the three-dimensional imaging to organization internal.
In the present embodiment, in addition to signal generator and power amplifier unit, the output end of the signal generator respectively with
The input of power amplifier unit connects with detection unit, for sending trigger signal, the output end and ultrasound unit of power amplifier unit
Input connection, signal generator be used for drive power amplifier unit and detection unit, the letter exported after being amplified by power amplifier unit
Focused ultrasonic transducer number can be made to send high-frequency ultrasonic, trigger imitative internal portion to produce the optical signal of sonoluminescence, this kind of light quilt
Quantum dot is absorbed, and launches near infrared light, and triggering letter is sent simultaneously to power amplifier unit and detection unit simultaneously from signal generator
Number, detection record is carried out to the near infrared light emitted by detection unit, completes three-dimensional imaging.Signal hair in the present embodiment
Raw device produces the electric signal that can drive ultrasound unit and detection detection, it is preferable that the signal of multichannel can be used to occur
Being delayed of the different passages of device, the persistently function such as triggering, it is " only triggering power amplifier, to produce individually pulsedly to trigger ultrasonic transducer
NIR light, then persistently receive signal and carry out detection record ".Signal generator can be controlled with the frequency of setting signal, dutycycle etc.
Parameter, ultrasound unit is controlled to send the high-frequency ultrasonic specified by control parameter.
Correspondingly, the present embodiment also provides a kind of method being imaged in bio-tissue, including：
Quantum dot is embedded in inside bio-tissue in advance；
Output ultrasonic wave simultaneously triggers the optical signal that sonoluminescence is produced in bio-tissue；
Optical signal caused by the sonoluminescence is converted to by infrared signal by quantum dot；
Infrared signal is detected and recorded, completes three-dimensional imaging.
In the present embodiment, by the way that infrared signal to be focused to the receiving plane of photomultiplier by optical fiber and lens group,
Infrared signal is amplified by photomultiplier and inputted to detection unit and is detected, while to power amplifier unit and detection
Unit sends synchronous triggering signal, is amplified trigger signal by power amplifier unit and triggers output high-frequency ultrasonic, triggers
The optical signal of sonoluminescence is produced inside bio-tissue, and detection is synchronized by detection unit.
In the present embodiment, during optical signal is gathered, it is also necessary to carry out filtration treatment to infrared signal, filter out red
Veiling glare in external signal, to improve the resolution ratio of imaging, by the position of mobile focused ultrasonic transducer, complete in tissue
The process of the three-dimensional imaging in portion, it is preferable that optical fiber and ultrasound unit in the present embodiment keep synchronizing moving, it is ensured that collection
The intensity of the signal arrived.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (10)
- A kind of 1. system being imaged in bio-tissue, it is characterised in that including：Ultrasound unit, for output ultrasonic wave and produce the optical signal of sonoluminescence；Quantum dot, for optical signal caused by the sonoluminescence to be converted into infrared signal, the quantum dot is pre-set at Inside bio-tissue；Detection unit, for being detected and being recorded to infrared signal, complete three-dimensional imaging.
- 2. the system according to claim 1 being imaged in bio-tissue, it is characterised in that also include：Collecting unit, for gathering infrared signal；The collecting unit includes optical fiber, lens group and photomultiplier, the output end of the optical fiber and the input of lens group Light is focused at the receiving plane of photomultiplier, the photomultiplier by optical fiber and lens group by connection, the infrared signal Output end and detection unit input connect.
- 3. the system according to claim 2 being imaged in bio-tissue, it is characterised in that also include：Signal generator, for sending control signal to ultrasound unit and detection unit；The output end of the signal generator is connected with the input and detection unit of power amplifier unit respectively, the power amplifier unit The input of output end and ultrasound unit connects；Power amplifier unit, for control signal to be amplified；The output end of the power amplifier unit and the input of ultrasound unit connect.
- 4. the system according to claim 3 being imaged in bio-tissue, it is characterised in that the lens group includes filter Mating plate, for being filtered to veiling glare in infrared signal.
- 5. the system according to claim 4 being imaged in bio-tissue, it is characterised in that the ultrasound unit is Assemble ultrasonic probe, the control parameter that the ultrasound unit is set according to signal generator is operated, the control parameter Including at least the frequency and dutycycle of signal.
- A kind of 6. method being imaged in bio-tissue, it is characterised in that including：Quantum dot is pre-set inside bio-tissue；Output ultrasonic wave simultaneously triggers the optical signal that sonoluminescence is produced in bio-tissue；Optical signal caused by the sonoluminescence is converted to by infrared signal by quantum dot；Infrared signal is detected and recorded, completes three-dimensional imaging.
- 7. the method according to claim 6 being imaged in bio-tissue, it is characterised in that infrared signal is passed through into light Fine and lens group is focused at the receiving plane of photomultiplier, and infrared signal is amplified by photomultiplier and inputted to inspection Unit is surveyed to be detected.
- 8. the method according to claim 7 being imaged in bio-tissue, it is characterised in that at the same to power amplifier unit and Detection unit sends synchronous triggering signal, is amplified trigger signal by power amplifier unit and to trigger ultrasound unit output super Sound wave, trigger the optical signal that sonoluminescence is produced inside bio-tissue, and detection is synchronized by detection unit.
- 9. the method according to claim 8 being imaged in bio-tissue, it is characterised in that carried out to infrared signal Filter is handled, and filters out the veiling glare in infrared signal.
- 10. the method according to claim 9 being imaged in bio-tissue, it is characterised in that according to default control The high-frequency ultrasonic of parameter triggering output different frequency and dutycycle, by the position of mobile ultrasound unit, complete organism The three-dimensional imaging of organization internal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711138938.XA CN107647852B (en) | 2017-11-16 | 2017-11-16 | System and method for imaging in organism tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711138938.XA CN107647852B (en) | 2017-11-16 | 2017-11-16 | System and method for imaging in organism tissue |
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| Publication Number | Publication Date |
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| CN107647852A true CN107647852A (en) | 2018-02-02 |
| CN107647852B CN107647852B (en) | 2020-05-12 |
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| CN201711138938.XA Expired - Fee Related CN107647852B (en) | 2017-11-16 | 2017-11-16 | System and method for imaging in organism tissue |
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Cited By (2)
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| CN108577810A (en) * | 2018-03-21 | 2018-09-28 | 华北电力大学（保定） | Solve the intravascular photoacoustic image rebuilding method and system of velocity of sound problem of non-uniform |
| IT202100005123A1 (en) | 2021-03-04 | 2022-09-04 | Torino Politecnico | METHOD AND APPARATUS FOR CONTRAST IMAGE IN SONOLUMINESCENCE ASSISTED BY NANOPARTICLES IN THE MEDICAL DIAGNOSTIC FIELD, IN PARTICULAR ONCOLOGY |
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| WO2007130001A2 (en) * | 2005-03-28 | 2007-11-15 | The University Of Akron | Multi-spectral mixed radiation, polarmetric systems |
| CN102743770A (en) * | 2012-06-18 | 2012-10-24 | 申宝忠 | Targeting molecular imaging probe and living molecular imaging method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108577810A (en) * | 2018-03-21 | 2018-09-28 | 华北电力大学（保定） | Solve the intravascular photoacoustic image rebuilding method and system of velocity of sound problem of non-uniform |
| IT202100005123A1 (en) | 2021-03-04 | 2022-09-04 | Torino Politecnico | METHOD AND APPARATUS FOR CONTRAST IMAGE IN SONOLUMINESCENCE ASSISTED BY NANOPARTICLES IN THE MEDICAL DIAGNOSTIC FIELD, IN PARTICULAR ONCOLOGY |
| WO2022185208A1 (en) | 2021-03-04 | 2022-09-09 | Politecnico Di Torino | Method and apparatus for nanoparticle-assisted sonoluminescence contrast imaging in medical diagnostics, particularly oncology |
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| CN107647852B (en) | 2020-05-12 |
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