CN107616988A - A kind of preparation method of Hypericum japonicum injection - Google Patents
A kind of preparation method of Hypericum japonicum injection Download PDFInfo
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- CN107616988A CN107616988A CN201710646174.9A CN201710646174A CN107616988A CN 107616988 A CN107616988 A CN 107616988A CN 201710646174 A CN201710646174 A CN 201710646174A CN 107616988 A CN107616988 A CN 107616988A
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- injection
- hypericum japonicum
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Abstract
The invention discloses a kind of preparation method of Hypericum japonicum injection, comprise the following steps：Take hypericum japonicum to clean, add injection boiling boiling extraction twice, extract 1h every time, filter；Filtrate, which merges, is concentrated into 1000ml, adds the ethanol of qdx 95%, is filtered to remove precipitation, reclaims ethanol；The extraction raffinate that step 2 is obtained adds acetic acid lead solution to make its precipitation, filters out precipitation；Lead is taken off with 2 equiv. sulfuric acids again, adjusts pH value to add to the full amount of water for injection, filter, embedding, sterilizing, thus obtaining the product to 56 with sodium carbonate.
Description
Technical field
The present invention relates to pharmaceutical technology field, and in particular to a kind of preparation method of Hypericum japonicum injection.
Background technology
Hypericum japonicum alias hypericum japonicum, it is annual herb；Stem is upright, very thin, herbaceous stem, high 10-30cm.Leaf is to life, stockless,
Avette or ovate lanceolata shape, long 7-10 millimeters, wide 1.5-6 millimeters, top is blunt, and base portion unobvious are heart-shaped, embraces stem, full edge, the back of the body
There is sparse black fleck in face；Base goes out vein 5.Spend summer to open, yellow, diameter about 6mm, line up basidixed cyme；
The long 5-10mm of bennet.Hypericum japonicum is the herb of Guttiferae hypericum hypericum japonicum, there is each province on the south China Yangtze river basin
Distribution, is annual herb plant, title hypericum japonicum among the people.Take orally for treating hepatitis, traumatic injury venomous snake bite, treating boil
Carbuncle, child convulsion, diarrhoea, mausoleum gas etc..Also external application can be mashed.
The content of the invention
To solve the above-mentioned problems in the prior art, the invention provides a kind of preparation side of Hypericum japonicum injection
Method, it is characterised in that comprise the following steps：
(1) take hypericum japonicum to clean, add injection boiling boiling extraction twice, extract 1h every time, filter；
(2) filtrate, which merges, is concentrated into 1000ml, adds the ethanol of qdx 95%, is filtered to remove precipitation, reclaims ethanol；
(3) add acetic acid lead solution to make its precipitation the extraction raffinate that step (2) obtains, filter out precipitation；
(4) lead is taken off with 2 equiv. sulfuric acids again, with sodium carbonate tune pH value to 5-6, adds to the full amount of water for injection, filter, embedding,
Sterilizing, thus obtaining the product.
Beneficial effects of the present invention：
A kind of preparation method for Hypericum japonicum injection that the present invention is to provide, its obtained Hypericum japonicum injection can be used for anxious
Property catarrhal jaundice, leptospirosis.
Embodiment
With reference to preferred embodiment, to according to embodiment provided by the invention, details are as follows：
Embodiment 1
A kind of preparation method of Hypericum japonicum injection, comprises the following steps：
(1) take hypericum japonicum (5000g) to clean, add injection boiling boiling extraction twice, extraction every time
1h, filtering；
(2) filtrate, which merges, is concentrated into 1000ml, adds the ethanol of qdx 95%, is filtered to remove precipitation, reclaims ethanol；
(3) add acetic acid lead solution to make its precipitation the extraction raffinate that step (2) obtains, filter out precipitation；
(4) lead is taken off with 2 equiv. sulfuric acids again, with sodium carbonate tune pH value to 5-6, adds to the full amount of water for injection, filter, embedding,
Sterilizing, thus obtaining the product.
The Hypericum japonicum injection that the method for embodiments of the invention is prepared is the sterile water solution of Herba Hyperici Japonici extract, often
Milliliter is equivalent to crude drug 5g, every 2ml.
Usage is, daily 1-2 times, each 2ml, intramuscular injection；Or 0.5-1ml makees acupoint injection therapy every time.
Beneficial effects of the present invention：
A kind of preparation method for Hypericum japonicum injection that the present invention is to provide, its obtained Hypericum japonicum injection can be used for anxious
Property catarrhal jaundice, leptospirosis.It is reported that Herba Hyperici Japonici extract is to ox type combination bacillus (five strains), the double balls of pneumonia
Bacterium, staphylococcus aureus, cholera bacilli, streptococcus etc. have different degrees of inhibitory action.
It should be noted that a kind of preparation method for Hypericum japonicum injection that embodiments of the invention provide, can also be first
With alcohol extracting, recrement extracts after with water, is then combined with the method that concentration dilutes again and prepares.
Claims (1)
1. a kind of preparation method of Hypericum japonicum injection, it is characterised in that comprise the following steps：
(1) take hypericum japonicum to clean, add injection boiling boiling extraction twice, extract 1h every time, filter；
(2) filtrate, which merges, is concentrated into 1000ml, adds the ethanol of qdx 95%, is filtered to remove precipitation, reclaims ethanol；
(3) add acetic acid lead solution to make its precipitation the extraction raffinate that step (2) obtains, filter out precipitation；
(4) lead is taken off with 2 equiv. sulfuric acids again, adjusts pH value to add to the full amount of water for injection, filter, embedding, sterilize to 5-6 with sodium carbonate
Produce.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710646174.9A CN107616988A (en) | 2017-08-01 | 2017-08-01 | A kind of preparation method of Hypericum japonicum injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710646174.9A CN107616988A (en) | 2017-08-01 | 2017-08-01 | A kind of preparation method of Hypericum japonicum injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107616988A true CN107616988A (en) | 2018-01-23 |
Family
ID=61088214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710646174.9A Pending CN107616988A (en) | 2017-08-01 | 2017-08-01 | A kind of preparation method of Hypericum japonicum injection |
Country Status (1)
| Country | Link |
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| CN (1) | CN107616988A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108324763A (en) * | 2018-03-12 | 2018-07-27 | 韩志波 | Compound Hypericum japonicum injection and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003000242A2 (en) * | 2001-06-25 | 2003-01-03 | Sky Biohealth Solutions, Inc. | Method for the treatment of lymphedema using guaifenesin |
| CN1528288A (en) * | 2003-10-21 | 2004-09-15 | 张晴龙 | Hypericum japonicum total flavone powder injection and preparing method thereof |
-
2017
- 2017-08-01 CN CN201710646174.9A patent/CN107616988A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003000242A2 (en) * | 2001-06-25 | 2003-01-03 | Sky Biohealth Solutions, Inc. | Method for the treatment of lymphedema using guaifenesin |
| CN1528288A (en) * | 2003-10-21 | 2004-09-15 | 张晴龙 | Hypericum japonicum total flavone powder injection and preparing method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 易醒等: "田基黄注射液采用吸附澄清法新工艺的研究", 《江西中医学院学报》 * |
| 武秀英等: "田基黄注射液的质量研究", 《中成药研究》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108324763A (en) * | 2018-03-12 | 2018-07-27 | 韩志波 | Compound Hypericum japonicum injection and preparation method thereof |
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180123 |
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| RJ01 | Rejection of invention patent application after publication |