CN107616175B - Composition containing ZJ10520 and pyridine bactericide - Google Patents
Composition containing ZJ10520 and pyridine bactericide Download PDFInfo
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Abstract
The invention discloses a composition containing ZJ10520 and pyridine bactericide and the bactericide thereof, the sterilization effect of the composition is obviously improved compared with that of a single bactericide, the composition has the advantages of treatment and protection effects, good sterilization effect and low medication cost, and can slow down the generation of resistance and prolong the service life of the bactericide.
Description
Technical Field
The invention belongs to the field of pesticides, and relates to a bactericidal composition for preventing and treating agricultural diseases.
Background
In agricultural production processes, fungal diseases are a major factor affecting yield and quality. In order to improve the yield and quality of crops, pesticides for preventing and treating diseases need to be used, and a bactericide is one of the pesticides. Commonly used bactericides can be classified into amides, dihydroxy imides, strobilurins, triazoles, imidazoles, oxazoles, thiazoles, morpholines, pyrroles, pyridines, pyrimidines, quinolines, carbamates, organophosphates, antibiotics and the like according to the chemical structure type. The pyridine bactericide is a variety with a large using amount, and mainly comprises fluazinam and boscalid.
Fluazinam (Fluazinam), chemical name: 3-chloro-N- (3-chloro-5-trifluoromethyl-2-pyridyl) -a, a, a-trifluoro-2, 6-dinitro-p-toluidine has broad-spectrum bactericidal activity, has special effect on a plurality of gray mold caused by botrytis cinerea, and has good activity on diseases caused by pathogenic bacteria such as alternaria, phytophthora, monascus, sclerotinia, cladosporium and the like. Has no cross resistance with benzimidazoles, dicarboxyl imides and the existing bactericides on the market at present.
Boscalid (Boscalid), chemical name: 2-chloro-N- (4' -chloro diphenyl-2-yl) nicotinamide belongs to succinate coenzyme Q reductase inhibitors in mitochondrial respiratory chain, has strong inhibition capability on spore germination, and can be used for preventing and treating powdery mildew, gray mold, various rot diseases, brown rot, root rot and the like. Has no cross resistance with other bactericides.
However, long-term use of the same variety of bactericide can cause the pesticide resistance of the pathogenic bacteria of the crops to be generated and reduce the control effect. For example, crop pathogens have developed some resistance to fluazinam and boscalid. In order to cope with the drug resistance of pathogenic bacteria, the sterilization active compounds with different action mechanisms are compounded to be a better method.
Therefore, the compounding of the pyridine bactericide and other bactericides is a way to solve the drug resistance of germs.
Disclosure of Invention
The invention aims to provide a composition which has the characteristics of good sterilization effect, low medication cost and difficult generation of drug resistance.
The invention provides the following technical scheme:
a composition comprises two active ingredients, wherein the first active ingredient is ZJ10520, and the second active ingredient is selected from pyridine bactericides.
The first active ingredient used in the present invention is ZJ10520, whose chemical name is: 3- (difluoromethyl) -5-fluoro-1-methyl-N- [2- (2-chloro-4-trifluoromethyl-phenoxy) phenyl ] pyrazole-4-carboxamide.
The second active ingredient used in the present invention is selected from the group consisting of pyridine fungicides. The pyridine bactericide is a pyridine bactericide commonly used in the industry.
Preferably, the pyridine bactericide is at least one selected from fluazinam and boscalid. When the pyridine bactericide is fluazinam, the composition contains ZJ10520 and fluazinam. When the pyridine bactericide is boscalid, the composition contains ZJ10520 and boscalid. When the pyridine bactericide is fluazinam and boscalid, the composition contains ZJ10520, fluazinam and boscalid.
The composition provided by the invention does not need to be specially matched with the two active ingredients.
Preferably, the mass ratio of the first active ingredient to the second active ingredient is 60: 1-1: 60.
More preferably, the mass ratio of the first active ingredient to the second active ingredient is 20: 1-1: 20.
More preferably, the mass ratio of the first active ingredient to the second active ingredient is 6: 1-1: 6.
Most preferably, the mass ratio of the first active ingredient to the second active ingredient is 3: 1-1: 3.
The composition provided by the invention can further comprise a third active ingredient. The third active component can be at least one selected from triazole bactericides, imidazole bactericides, oxazole bactericides, amide bactericides, dicarboximide bactericides, thiazole bactericides, pyrrole bactericides, morpholine bactericides, methoxy acrylate bactericides, pyrimidine bactericides, quinoline bactericides, organophosphorus bactericides, carbamate bactericides and antibiotic bactericides.
The composition provided by the invention is suitable for sterilization, and is particularly suitable for agricultural sterilization.
Preferably, the compositions provided by the present invention are suitable for controlling at least one selected from the group consisting of sclerotinia, root rot, brown rot, gray mold, rot, downy mildew, anthracnose, powdery mildew, late blight, scab, leaf spot, black spot, rust, rice blast, sheath blight, spot disease and scab.
Further preferably, the composition provided by the invention is used for preventing and treating at least one selected from the group consisting of phytophthora blight of capsicum, sclerotinia rot of colza, early blight of tomato, gray mold of grape, late blight of potato, anthracnose of capsicum and clubroot of Chinese cabbage.
The invention also provides a bactericide which comprises more than 0.1% by weight of the composition.
Preferably, the bactericide contains 1 to 90% by weight of the composition.
It is further preferred that the bactericide comprises 5 to 80% by weight of the composition.
The bactericide provided by the invention can further comprise agriculturally acceptable carriers and auxiliaries besides the composition.
The carrier of the present invention may be a solid or a liquid, and any carrier commonly used for formulating agricultural pharmaceutical compositions can be used.
Suitable solid supports include: minerals, plants, synthetic fillers and inorganic salts. Wherein the minerals include silicates, carbonates, sulfates and oxides. Silicates such as kaolin, sepiolite, nacrite, montmorillonite, mica, vermiculite, pyrophyllite, talc. Carbonates such as: calcium carbonate and dolomite. Sulfates such as ammonium sulfate, sodium sulfate, calcium sulfate. Oxides such as quicklime, magnesia lime, diatomaceous earth. Plants such as: citrus pulp, corn cob cores, rice hull powder, rice hulls, soybean straw powder, tobacco powder, walnut shells and sawmilling powder. Synthetic fillers such as precipitated calcium carbonate hydrate, precipitated calcium carbonate, white carbon black. Inorganic salts such as potassium chloride, sodium chloride.
The liquid carrier includes water and an organic solvent. When the active ingredient is a suspoemulsion, the organic solvent plays a role in solubilization and freeze protection. Suitable organic solvents include aromatic hydrocarbons such as benzene, xylene, toluene, alkylbenzenes, alkylnaphthalenes, and chlorinated aromatic hydrocarbons; chlorinated aliphatic hydrocarbons such as vinyl chloride, chloroform, methylene chloride, chloroform, carbon tetrachloride and polychlorinated ethane; aliphatic hydrocarbons such as petroleum fractions, cyclohexane, light mineral oil and paraffin wax. Alcohols such as methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol, fatty alcohols, and the like; ethers such as methyl glycol ether, ethyl glycol ether, petroleum ether. Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone, and isophorone, N-methyl-pyrrolidone; the special solvent also comprises dimethylformamide, dimethyl sulfoxide, polyethylene glycol and hexanenitrile; vegetable oils and methylated vegetable oils. The organic solvents mentioned above may be used alone, or in admixture with water.
The auxiliary agent can comprise one or more of a surfactant, an antifoaming agent, a thickening agent, a suspending agent and an antifreezing agent according to needs, and can also comprise other auxiliary agents commonly used in the industry according to needs.
The surfactant can be an emulsifier, dispersant, stabilizer or wetting agent; may be ionic or non-ionic. Suitable surfactants include: sodium and calcium salts of polyacrylic acid and lignosulfonic acid; polycondensation products of fatty acids or fatty amines containing at least 12 carbon atoms in the molecule with ethylene oxide and/or propylene oxide; fatty acid esters of glycerol, dodecanol-1, tetradecanol-1, sorbitol, sucrose, or pentaerythritol; and their polycondensation products with ethylene oxide and/or propylene oxide; sulfates or sulfonates of their polycondensation products; alkali metal or alkaline earth metal salts of sulfuric acid or sulfonic acid having at least 10 carbon atoms in the molecule, preferably sodium salts such as sodium lauryl sulfate, sodium secondary alkyl sulfate, sodium salt of sulfonated castor oil, sodium alkylaryl sulfonate and sodium dodecylbenzene sulfonate; polymers of ethylene oxide, copolymers of ethylene oxide and propylene oxide.
The emulsifier includes nonionic emulsifier and anionic emulsifier. The nonionic emulsifier is preferably nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, styrylphenyl polyoxyethylene ether, alkylphenol formaldehyde resin polyoxyethylene ether, hydroxyl-terminated polyoxyethylene polyoxypropylene ether, styrylphenol formaldehyde resin polyoxyethylene polyoxypropylene ether, and castor oil polyoxyethylene ether. The anionic emulsifier mainly comprises calcium dodecyl benzene sulfonate, ammonium triphenethyl phenol polyoxyethylene ether phosphate, ammonium nonylphenol polyoxyethylene ether phosphate and ammonium castor oil polyoxyethylene ether phosphate.
The dispersant of the invention comprises: one or more of acrylic acid homopolymer sodium salt, maleic acid disodium salt, naphthalene sulfonic acid formaldehyde condensate sodium salt, rosin block polyoxyethylene ether polyoxypropylene ether sulfonate, hydroxyl-terminated polyoxyethylene polyoxypropylene ether block copolymer, triphenyl ethyl phenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphoric acid and p-hydroxyphenyl lignin sulfonic acid sodium salt.
The humectants of the present invention include: one or more of fatty alcohol-polyoxyethylene ether, naphthalene sulfonate, sodium dodecyl sulfate and alkylphenol resin polyoxyethylene ether sulfate.
The thickening agent comprises one or more of xanthan gum, magnesium aluminum silicate, sodium alginate, sodium carboxymethylcellulose, Arabic gum, gelatin and polyvinyl alcohol.
The defoaming agent of the present invention is preferably: molinate, silicones, C8～10Fatty alcohol, C10～20Saturated fatty acids, amides, and the like.
The fungicide according to the present invention can be formulated into any agriculturally acceptable dosage form as required.
Preferably, the bactericide may be formulated into a powdery preparation, a granular preparation, a dispersible powdery preparation, a dispersible granular preparation, a dispersible tablet preparation, a soluble solid preparation, a soluble liquid preparation, an oil preparation, an ultra-low volume preparation, a dispersible liquid preparation, an emulsion preparation, a suspension preparation, a suspoemulsion preparation or a seed coating preparation.
Preferably, the powdered formulation is selected from a powder, a contact powder or a floating powder.
Preferably, the granular formulation is selected from granules, macrogranules, fine granules, microgranules or microencapsulated granules.
Preferably, the dispersible powder formulation is selected from a wettable powder or an oil dispersible powder.
Preferably, the dispersible granular formulation is selected from water dispersible granules, milk granules or effervescent granules.
Preferably, the dispersible tablet formulation is selected from a dispersible tablet or an effervescent tablet.
Preferably, the soluble solid formulation is selected from soluble powders, soluble granules or soluble tablets.
Preferably, the soluble liquid formulation is selected from a solubles, a water aqua, or a sol.
Preferably, the oil formulation is selected from an oil or a spreading oil.
Preferably, the ultra-low volume formulation is selected from an ultra-low volume liquid formulation or an ultra-low volume microcapsule suspension.
Preferably, the dispersible liquid formulation is selected from emulsifiable concentrates or dispersible liquid formulations.
Preferably, the emulsion formulation is selected from an aqueous emulsion, an oil emulsion or a microemulsion.
Preferably, the suspending agent is selected from a suspending agent, a microcapsule suspending agent or an oil suspending agent.
Preferably, the seed coating is selected from an aqueous suspension seed coating, a dispersible powder seed coating or a dispersible granule seed coating.
Compared with the prior art, the composition and the bactericide have the following advantages:
(1) the two active ingredients in the composition are compounded to show excellent synergistic effect, the sterilization effect of the mixed composition is obviously improved compared with that of a single agent, and the composition has good sterilization effect and treatment and protection effects;
(2) the dosage and the cost are reduced;
(3) the two active ingredients are reasonably mixed by different action modes and different action mechanisms, so that the service life of the bactericide is prolonged, the generation of resistance is slowed down, the safety to crops is good, and the safety requirement of pesticide preparations is met.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to limit the invention to these embodiments. It will be appreciated by those skilled in the art that the present invention encompasses all alternatives, modifications and equivalents as may be included within the scope of the claims.
First, bioassay example
Example 1, indoor virulence determination of the Compound pairing of ZJ10520 and fluazinam to Phytophthora capsici
Test subjects: phytophthora capsici (Phytophthora capsicii) is preserved in the unit strain room.
The test method comprises the following steps: refer to the hypha growth rate method of agricultural industry Standard NY/T1156.2-2006 of the people's republic of China. Each medicament is respectively treated by 5 dosages according to the content of effective components, the pathogenic bacteria are cultured by a PDA culture medium, when bacterial colonies grow to a culture dish, a puncher with the diameter of 5mm is used for punching bacterial blocks at the edges of the bacterial colonies, the bacterial blocks are moved to the center of a prepared toxic PDA culture medium by an inoculation needle, and then the bacterial blocks are placed in a 25 ℃ culture box for culture, and the treatment is repeated for 4 times. According to the growth condition of CK colonies, the diameter cm of each treated colony is measured by a caliper by adopting a cross method, and the corrected inhibition percentage is calculated. The EC of each drug was determined by linear regression analysis between the probability of inhibition and the logarithm of the series of concentrations50The co-toxicity coefficient (CTC) was then calculated according to the Sun cloud Peel method.
And (3) calculating the drug effect: two diameters were cross-measured per colony, and the average was used to represent colony size. The colony growth inhibition rate was determined according to the following formula: the colony growth inhibition ratio ═ g (blank colony growth diameter-agent-treated colony growth diameter) × 100/blank colony growth diameter.
The results were subjected to data analysis and statistics using the 3.11 professional edition to determine a regression line, EC50, and a correlation coefficient. EC50 for each treatment was converted to the Actual Toxicity Index (ATI) by the Sun cloud Peel (Y-P Sun); obtaining a Theoretical Toxicity Index (TTI) according to the mixture ratio of the mixture, and calculating the co-toxicity coefficient (CTC) of the mixture according to the following formula.
Theoretical virulence index of the mix (TTI) ═ A virulence index x A content in the mix (%)
+ B virulence index x B content in the mix (%)
If the co-toxicity coefficient is more than 120, the synergistic effect is shown; if the concentration is obviously lower than 100%, antagonism is indicated; between 100 and 120, the additive effect is shown.
Table 1, indoor toxicity test results of compound pairing of ZJ10520 and fluazinam on pepper phytophthora blight
| Medicament | EC50(μg/mL) | ATI | TTI | Co-toxicity coefficient CTC |
| ZJ10520(A) | 22.41 | 100.00 | / | / |
| Fluazinam (B) | 0.27 | 8300.00 | / | / |
| A+B(20：1) | 3.24 | 691.67 | 490.48 | 141.02 |
| A+B(16：1) | 2.45 | 914.69 | 582.35 | 157.07 |
| A+B(12：1) | 1.79 | 1251.96 | 730.77 | 171.32 |
| A+B(6：1) | 0.83 | 2700.00 | 1271.43 | 212.36 |
| A+B(3：1) | 0.41 | 5465.85 | 2150.00 | 254.23 |
| A+B(1：1) | 0.19 | 11794.74 | 4200.00 | 280.83 |
| A+B(1：3) | 0.18 | 12450.00 | 6250.00 | 199.20 |
| A+B(1：6) | 0.16 | 14006.25 | 7128.57 | 196.48 |
| A+B(1：12) | 0.18 | 12450.00 | 7669.23 | 162.34 |
| A+B(1：16) | 0.22 | 10186.36 | 7817.65 | 130.30 |
| A+B(1：20) | 0.23 | 9743.48 | 7909.52 | 123.19 |
Example 2 indoor toxicity determination of compounding ZJ10520 and fluazinam on pepper anthracnose
Test subjects: colletotrichum capsicium (Colletotrichum capsicii) is preserved in the unit strain chamber. Test methods and drug efficacy calculation methods refer to example 1.
Table 2, indoor toxicity test results of the combination of ZJ10520 and fluazinam on pepper anthracnose
Example 3, indoor virulence determination of ZJ10520 in combination with fluazinam for potato late blight
Test subjects: potato late blight bacteria (Phytophthora infestans) are preserved in the unit strain chamber. Test methods and calculation of drug efficacy in reference example 1, the medium used was rye sucrose agar medium.
Table 3, ZJ10520 and fluazinam compound pair potato late blight indoor toxicity determination result
| Medicament | EC50(μg/mL) | ATI | TTI | Co-toxicity coefficient CTC |
| ZJ10520(A) | 10.33 | 100.00 | / | / |
| Fluazinam (B) | 0.45 | 2295.56 | / | / |
| A+B(20：1) | 3.68 | 280.71 | 204.55 | 137.23 |
| A+B(16：1) | 3.11 | 332.15 | 229.15 | 144.95 |
| A+B(12：1) | 2.36 | 437.71 | 268.89 | 162.79 |
| A+B(6：1) | 1.35 | 765.19 | 413.65 | 184.98 |
| A+B(3：1) | 0.85 | 1215.29 | 648.89 | 187.29 |
| A+B(1：1) | 0.43 | 2402.33 | 1197.78 | 200.56 |
| A+B(1：3) | 0.33 | 3130.30 | 1746.67 | 179.22 |
| A+B(1：6) | 0.28 | 3689.29 | 1981.91 | 186.15 |
| A+B(1：12) | 0.31 | 3332.26 | 2126.67 | 156.69 |
| A+B(1：16) | 0.32 | 3228.13 | 2166.41 | 149.01 |
| A+B(1：20) | 0.34 | 3038.24 | 2191.01 | 138.67 |
Example 4 indoor virulence determination of Botrytis cinerea compounded by ZJ10520 and boscalid
Test subjects: botrytis cinerea (Botrytis cinerea), which is preserved in the unit seed room. Test methods and calculation methods refer to example 1.
Table 4, indoor toxicity measurement results of grape gray mold compounded by ZJ10520 and boscalid
Example 5, indoor toxicity determination of ZJ10520 and boscalid on tomato early blight
Test subjects: tomato early blight pathogen (Alternaria solani), which is preserved by the unit bacterial chamber. Test methods and calculation methods refer to example 1.
Table 5, indoor toxicity determination results of compounding ZJ10520 and boscalid on tomato early blight
| Medicament | EC50(μg/mL) | ATI | TTI | Co-toxicity coefficient CTC |
| ZJ10520(A) | 13.05 | 100.00 | / | / |
| Boscalid (B) | 7.08 | 184.32 | / | / |
| A+B(20：1) | 7.58 | 172.16 | 104.02 | 165.52 |
| A+B(16：1) | 7.12 | 183.29 | 104.96 | 174.63 |
| A+B(12：1) | 6.55 | 199.24 | 106.49 | 187.10 |
| A+B(6：1) | 5.77 | 226.17 | 112.05 | 201.85 |
| A+B(3：1) | 4.85 | 269.07 | 121.08 | 222.23 |
| A+B(1：1) | 4.06 | 321.43 | 142.16 | 226.10 |
| A+B(1：3) | 4.03 | 323.82 | 163.24 | 198.37 |
| A+B(1：6) | 4.12 | 316.75 | 172.27 | 183.86 |
| A+B(1：12) | 4.36 | 299.31 | 177.83 | 168.31 |
| A+B(1：16) | 4.61 | 283.08 | 179.36 | 157.83 |
| A+B(1：20) | 5.11 | 255.38 | 180.30 | 141.64 |
Example 6 determination of indoor toxicity of combination of ZJ10520 and boscalid on sclerotinia rot of colza
Test subjects: sclerotinia sclerotiorum (sclerotitiorum) was stored in the laboratory. Test methods and calculation methods refer to example 1.
Table 6, indoor toxicity test results of boscalid and ZJ10520 on sclerotinia rot of colza
| Medicament | EC50(μg/mL) | ATI | TTI | Co-toxicity coefficient CTC |
| ZJ10520(A) | 5.03 | 100.00 | / | / |
| Boscalid (B) | 2.87 | 175.26 | / | / |
| A+B(20：1) | 3.66 | 137.43 | 103.58 | 132.68 |
| A+B(16：1) | 3.21 | 156.70 | 104.43 | 150.05 |
| A+B(12：1) | 2.75 | 182.91 | 105.79 | 172.90 |
| A+B(6：1) | 2.46 | 204.47 | 110.75 | 184.62 |
| A+B(3：1) | 2.05 | 245.37 | 118.82 | 206.51 |
| A+B(1：1) | 1.61 | 312.42 | 137.63 | 227.00 |
| A+B(1：3) | 1.53 | 328.76 | 156.45 | 210.14 |
| A+B(1：6) | 1.49 | 337.58 | 164.51 | 205.21 |
| A+B(1：12) | 1.63 | 308.59 | 169.47 | 182.09 |
| A+B(1：16) | 2.11 | 238.39 | 170.83 | 139.54 |
| A+B(1：20) | 2.31 | 217.75 | 171.68 | 126.84 |
Example 7: indoor toxicity determination method for strawberry gray mold through ternary compounding of ZJ10520, boscalid and pyraclostrobin
Test subjects: botrytis cinerea, which is stored in the laboratory. Test methods and drug efficacy calculations refer to example 1.
Table 7, ZJ10520, boscalid and pyraclostrobin ternary combination indoor toxicity determination results for strawberry gray mold
Second, preparation examples
The preparation method of the suspending agent comprises the following steps: mixing the effective components, wetting agent, dispersant, antifreezing agent, etc. homogeneously, grinding in sand mill to certain size and filtering. Adding the prepared xanthan gum and stirring uniformly to obtain the suspending agent.
Example 8, 40% ZJ 10520. fluazinam suspension
10% of ZJ10520, 30% of fluazinam, 4% of acrylic acid homopolymer sodium salt, 1% of fatty alcohol-polyoxyethylene ether, 3% of propylene glycol, 0.3% of organic silicone oil, 0.2% of potassium sorbate, 0.15% of xanthan gum and water to make up to 100%.
Example 9, 10% ZJ10520 suspension
10 percent of ZJ10520, 4 percent of acrylic acid homopolymer sodium salt, 1 percent of fatty alcohol-polyoxyethylene ether, 3 percent of propylene glycol, 0.3 percent of organic silicone oil, 0.2 percent of potassium sorbate, 0.15 percent of xanthan gum and water to be supplemented to 100 percent
Third, field application example
Example 10 field efficacy test for controlling cabbage clubroot
The test site is Hangzhou warehouse front base, the test agent, the control agent and the blank control are arranged in random block groups, and the area of the cell is 25m2And repeating for 4 times, spraying the soil in the whole field or the planting holes before sowing or planting the Chinese cabbages, and then uniformly mixing the soil by 10-15 cm. Investigating the disease degree of the underground parts of the Chinese cabbages 35 times after the last pesticide application, sampling 5 points in each cell, investigating 8 plants in each point, and calculating the disease index and the prevention and treatment effect according to the grading standard.
The classification criteria are as follows:
level 0: no clubroot attachment;
level 1: the clubroot is only attached to the lateral roots, and the quantity of the clubroot accounts for 1 to 25 percent of the total root system;
and 2, stage: the main root is attached with the clubroot, and the number of the clubroot on the lateral root accounts for more than 25 percent of the total root system;
and 3, level: the root system with 50-75% of the number of clubroots is attached to the main root;
4, level: the number of clubroots accounts for over 75 percent of the root system, and clubroots are attached to the main root.
Disease index [ sigma (number of diseased plants at each stage × relative stage)/(total number of investigated plants × 4) ] × 100
The preventing and treating effect is [ (disease index in blank control area-treating disease index)/disease index in blank control area ] × 100
TABLE 8 field test results of efficacy of 40% ZJ10520 fluazinam suspension for controlling clubroot of Chinese cabbage
From the above embodiments, the composition provided by the invention can well prevent and treat pepper phytophthora blight, rape sclerotinia rot, tomato early blight, grape gray mold, potato late blight, pepper anthracnose and Chinese cabbage clubroot, the activity and the bactericidal effect of the composition are not simple superposition of the activities of all components, but have obvious synergistic effect, and meanwhile, the composition can also slow down the generation of resistance, is safe for crops, and meets the safety requirement of pesticide preparations.
Claims (11)
1. A composition characterized in that it comprises two active ingredients, the first active ingredient being ZJ10520, chemically named: the composition comprises 3- (difluoromethyl) -5-fluoro-1-methyl-N- [2- (2-chloro-4-trifluoromethyl-phenoxy) phenyl ] pyrazole-4-formamide and a second active ingredient, wherein the second active ingredient is selected from a pyridine bactericide, the mass ratio of the first active ingredient to the second active ingredient is 60: 1-1: 60, and the pyridine bactericide is selected from at least one of fluazinam and boscalid.
2. The composition according to claim 1, wherein the mass ratio of the first active ingredient to the second active ingredient is 20: 1-1: 20.
3. The composition according to claim 2, wherein the mass ratio of the first active ingredient to the second active ingredient is 6:1 to 1: 6.
4. The composition according to claim 3, wherein the mass ratio of the first active ingredient to the second active ingredient is 3:1 to 1: 3.
5. A fungicide characterized by containing, by weight, more than 0.1% of the composition according to any one of claims 1 to 4.
6. The fungicide according to claim 5, characterized in that said fungicide contains said composition in an amount of 1% to 90% by weight.
7. The fungicide according to claim 6, characterized in that said fungicide contains 5% to 80% by weight of said composition.
8. The fungicide according to claim 5, characterized in that the fungicide is formulated into a powdery preparation, a granular preparation, a dispersible powdery preparation, a dispersible granular preparation, a dispersible tablet preparation, a soluble solid preparation, a soluble liquid preparation, an oil preparation, an ultra-low volume preparation, a dispersible liquid preparation, an emulsion preparation, a suspension preparation, a suspoemulsion preparation or a seed coating preparation.
9. The bactericide as claimed in claim 8, wherein: the powdery preparation is selected from powder, contact powder or floating powder, the granular preparation is selected from granules, large granules, fine granules, micro granules or micro capsule granules, the dispersible powdery preparation is selected from wettable powder or oil dispersible powder, the dispersible granular preparation is selected from water dispersible granules, emulsion granules or effervescent granules, the dispersible tablet preparation is selected from dispersible tablets or effervescent tablets, the soluble solid preparation is selected from soluble powder, soluble granules or soluble tablets, the soluble liquid preparation is selected from soluble solution, water aqua or soluble gum agent, the oil preparation is selected from oil solution or film-spreading oil solution, the ultra-low volume preparation is selected from ultra-low volume liquid preparation or ultra-low volume micro capsule suspension, the separable liquid preparation is selected from missible oil or dispersible solution, the emulsion preparation is selected from emulsion in water, oil emulsion or microemulsion, the suspension preparation is selected from suspension, oil emulsion in water, or microemulsion, The microcapsule suspension or oil suspension is selected from water suspension seed coating, dispersible powder seed coating or dispersible granule seed coating.
10. Use of a composition according to claim 1, characterized in that the composition is used for controlling at least one selected from the group consisting of sclerotinia, root rot, brown rot, gray mold, rot, downy mildew, anthracnose, late blight, scab, leaf spot, black spot, rust, rice blast, sheath blight, spot disease and scab.
11. Use of a composition according to claim 10, characterized in that the composition is used for controlling at least one selected from the group consisting of phytophthora capsici, sclerotinia rot of colza, early blight of tomato, gray mold of grape, late blight of potato, anthracnose of capsicum, and clubroot of chinese cabbage.
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| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
| CN104557709A (en) * | 2013-10-23 | 2015-04-29 | 华中师范大学 | Pyrazole amide compound containing diphenyl ether, and application and pesticide composition of pyrazole amide compound |
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
| CN104557709A (en) * | 2013-10-23 | 2015-04-29 | 华中师范大学 | Pyrazole amide compound containing diphenyl ether, and application and pesticide composition of pyrazole amide compound |
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| CN107616175A (en) | 2018-01-23 |
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