CN107596417A - Sterilization method and thimerosal of a kind of medicine equipment and preparation method thereof - Google Patents
Sterilization method and thimerosal of a kind of medicine equipment and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of fine, more particularly to a kind of sterilization method of medicine equipment and thimerosal and preparation method thereof.Each component of the thimerosal is：Eucalyptus oil, kuh-seng, honeysuckle, the bark of official magnolia, radix glycyrrhizae, Asiatic plantain, HERBA VERONICAE DILATATAE, crab seven, radix scutellariae, cordate houttuynia, Chinese prickly ash, anise, ginger, radix bupleuri, the coptis, peppermint, Ligusticum wallichii, granatum, chrysanthemum, madder, frutus cnidii, glycerine, sodium acid carbonate and surfactant.The thimerosal of the medical apparatus sterilizing of the present invention is using decocting for Chinese herbal medicine liquid as primary raw material, it can effectively suppress and kill the bacteriums such as hepatitis viruse, bacillus enteritidis, shigella dysenteriae, Escherichia coli, influenza virus, virus, play the effect of broad-spectrum antiseptic, adding anion surfactant simultaneously, there is good cleaning performance for blood stains, sweat etc., and long-term use also will not produce harmful effect to skin, use is safer, and decontamination is more thorough；The thimerosal is non-foaming, easy to use simultaneously.
Description
Technical field
The invention belongs to technical field of fine, more particularly to a kind of thimerosal of medical apparatus sterilizing and its preparation
Method.
Background technology
With the development of society, the personal medicine equipment usage amount of personal use is increasing, for personal medicine equipment
Sterilization requirement also more and more higher, while as people also increasingly pay attention to health, the flow of the people of hospital is also increasing, respectively
Kind virus, germ are also adjoint, drastically influence the health of patient and medical personnel, existing sterilization method has ultraviolet to kill
Bacterium lamp, air sterilizing apparatus etc., but it is above-mentioned be required for the sterilizing chambers special to hospital just to carry out disinfection, for personal user,
Costly, use is inconvenient, and some thimerosal smells are too big, and patient can not endure, therefore needs now a kind of to environment
Influence small.
The content of the invention
In order to solve the above problems, it is an object of the invention to provide a kind of easy to use, a variety of Chinese medicine composition is added, is had
Good bactericidal action, while the normal activity of people is not interfered with, while handled using surfactant, it is widely used in curing
Treat Chinese medicine composition of medical apparatus sterilizing of equipment and preparation method thereof.
The technical scheme is that：A kind of thimerosal of medical apparatus sterilizing, the quality of each component of the thimerosal
Number is：
Eucalyptus oil 15-20 parts, kuh-seng 4-8 parts, honeysuckle 5-9 parts, bark of official magnolia 6-8 parts, radix glycyrrhizae 5.5-7.5 parts, Asiatic plantain
4.2-6.8 parts, HERBA VERONICAE DILATATAE 2.2-5.4 parts, the 1.6-3.9 parts of crab seven, radix scutellariae 1-3 parts, cordate houttuynia 10-12 parts, Chinese prickly ash 9-12 parts,
Anistree 6-8 parts, ginger 10-12 parts, radix bupleuri 3-5 parts, coptis 2-4 parts, peppermint 5-8, Ligusticum wallichii 3-8 parts, granatum 1-5 parts, chrysanthemum 8-
12 parts, madder 3-8 parts, frutus cnidii 6-8 parts, glycerine 10-15 parts, sodium acid carbonate 2-3 parts, surfactant 3-5 parts.
Further, a kind of thimerosal of medical apparatus sterilizing, the mass fraction of each component of the thimerosal are：Eucalyptus oil
16-18 parts, kuh-seng 5-6 parts, honeysuckle 6-7 parts, bark of official magnolia 6-8 parts, radix glycyrrhizae 5.5-7.5 parts, Asiatic plantain 5-6 parts, HERBA VERONICAE DILATATAE 3-4
Part, the 2-3.5 parts of crab seven, radix scutellariae 1-3 parts, cordate houttuynia 10-12 parts, Chinese prickly ash 10-11 parts, anistree 6-8 parts, ginger 10-12 parts, radix bupleuri
3-5 parts, coptis 2-4 parts, peppermint 5-8, Ligusticum wallichii 3-8 parts, granatum 2-4 parts, chrysanthemum 8-12 parts, madder 3-8 parts, frutus cnidii 6-8
Part, glycerine 12-13 parts, sodium acid carbonate 2-3 parts, surfactant 3.5-4.5 parts.
Further, a kind of thimerosal of medical apparatus sterilizing, the mass fraction of each component of the thimerosal are：Eucalyptus oil
16th, 5 parts of part kuh-seng, 6 parts of honeysuckle, 6 parts of the bark of official magnolia, 5.5 parts of radix glycyrrhizae, 5 parts of Asiatic plantain, 3 parts of HERBA VERONICAE DILATATAE, 72 parts of crab, radix scutellariae 1
Part, 10 parts of cordate houttuynia, 10 parts of Chinese prickly ash, anistree 6 parts, 10 parts of ginger, 3 parts of radix bupleuri, coptis 2-4 parts, peppermint 5,3 parts of Ligusticum wallichii, granatum 2
Part, 8 parts of chrysanthemum, 3 parts of madder, 6 parts of frutus cnidii, 12 parts of glycerine, 2 parts of sodium acid carbonate, 3.5 parts of surfactant.
Further, a kind of thimerosal of medical apparatus sterilizing, the mass fraction of each component of the thimerosal are：
18 parts of eucalyptus oil, 8 parts of kuh-seng, 9 parts of honeysuckle, 8 parts of the bark of official magnolia, 7.5 parts of radix glycyrrhizae, 6.8 parts of Asiatic plantain, HERBA VERONICAE DILATATAE 5.4
Part, 7 3.9 parts of crab, 3 parts of radix scutellariae, 12 parts of cordate houttuynia, 12 parts of Chinese prickly ash, anistree 8 parts, ginger 10-12 parts, 5 parts of radix bupleuri, 4 parts of the coptis,
Peppermint 8,8 parts of Ligusticum wallichii, 5 parts of granatum, 12 parts of chrysanthemum, 8 parts of madder, 8 parts of frutus cnidii, 15 parts of glycerine, 3 parts of sodium acid carbonate, surface
Activating agent 4.5.
Further, the surfactant is anion surfactant LAS, K12
It is a further object of the present invention to provide a kind of above-mentioned preparation technology of the thimerosal of medical apparatus sterilizing, the technique
Specifically include following steps：
Step 1：By kuh-seng, honeysuckle, the bark of official magnolia, radix glycyrrhizae, Asiatic plantain, HERBA VERONICAE DILATATAE, crab seven, radix scutellariae, cordate houttuynia, Chinese prickly ash,
Anise, ginger, radix bupleuri, the coptis, peppermint, Ligusticum wallichii, granatum, chrysanthemum, madder, frutus cnidii mix in proportion, dry, pulverize to
100-300 mesh powder；
Step 2：The powder that step 1 is prepared is with deionized water according to 2-5:9-13 ratios mix, and are turned with 100-200
Speed persistently stirs 12-24h, is added in container, is then heated to 100-120 DEG C, is incubated 40-45min, then decoct 2- with small fire
3h, the dregs of a decoction are filtered off, 2-8min is centrifuged under 300-400r/min using centrifuge, takes supernatant, be cooled to 8-10 DEG C, then will
Supernatant mixes with glycerine, adds surfactant and is well mixed, then add sodium acid carbonate and eucalyptus oil, is well mixed i.e.
Can.
The beneficial effects of the invention are as follows：Due to using above-mentioned technical proposal, the sterilization of medical apparatus sterilizing of the invention
Liquid using decocting for Chinese herbal medicine liquid as primary raw material, can effectively suppress and kill hepatitis viruse, bacillus enteritidis, shigella dysenteriae, large intestine bar
The bacteriums such as bacterium, influenza virus, virus, the effect of broad-spectrum antiseptic is played, while adding anion surfactant, for blood
Dirt, sweat etc. have good cleaning performance, and long-term use also will not produce harmful effect to skin, and use is safer, goes
It is dirty more thorough；The thimerosal is non-foaming, easy to use simultaneously.
Embodiment
Technical scheme is described further with reference to specific implementation.
A kind of thimerosal of medical apparatus sterilizing of the present invention, the mass fraction of each component of the thimerosal are：
Eucalyptus oil 15-20 parts, kuh-seng 4-8 parts, honeysuckle 5-9 parts, bark of official magnolia 6-8 parts, radix glycyrrhizae 5.5-7.5 parts, Asiatic plantain
4.2-6.8 parts, HERBA VERONICAE DILATATAE 2.2-5.4 parts, the 1.6-3.9 parts of crab seven, radix scutellariae 1-3 parts, cordate houttuynia 10-12 parts, Chinese prickly ash 9-12 parts,
Anistree 6-8 parts, ginger 10-12 parts, radix bupleuri 3-5 parts, coptis 2-4 parts, peppermint 5-8, Ligusticum wallichii 3-8 parts, granatum 1-5 parts, chrysanthemum 8-
12 parts, madder 3-8 parts, frutus cnidii 6-8 parts, glycerine 10-15 parts, sodium acid carbonate 2-3 parts, surfactant 3-5 parts.
A kind of thimerosal of medical apparatus sterilizing, the mass fraction of each component of the thimerosal are：Eucalyptus oil 15-20
Part, kuh-seng 5-6 parts, honeysuckle 6-7 parts, bark of official magnolia 6-8 parts, radix glycyrrhizae 5.5-7.5 parts, Asiatic plantain 5-6 parts, HERBA VERONICAE DILATATAE 3-4 parts, crab
Seven 2-3.5 parts, radix scutellariae 1-3 parts, cordate houttuynia 10-12 parts, Chinese prickly ash 10-11 parts, anistree 6-8 parts, ginger 10-12 parts, radix bupleuri 3-5 parts,
Coptis 2-4 parts, peppermint 5-8, Ligusticum wallichii 3-8 parts, granatum 2-4 parts, chrysanthemum 8-12 parts, madder 3-8 parts, frutus cnidii 6-8 parts, glycerine
12-13 parts, sodium acid carbonate 2-3 parts, surfactant 3.5-4.5 parts.A kind of system of the thimerosal of above-mentioned medical apparatus sterilizing
Standby technique, the technique specifically include following steps：
Step 1：By kuh-seng, honeysuckle, the bark of official magnolia, radix glycyrrhizae, Asiatic plantain, HERBA VERONICAE DILATATAE, crab seven, radix scutellariae, cordate houttuynia, Chinese prickly ash,
Anise, ginger, radix bupleuri, the coptis, peppermint, Ligusticum wallichii, granatum, chrysanthemum, madder, frutus cnidii mix in proportion, dry, pulverize to
100-300 mesh powder；
Step 2：The powder that step 1 is prepared is with deionized water according to 2-5:9-13 ratios mix, and are turned with 100-200
Speed persistently stirs 12-24h, is added in container, is then heated to 100-120 DEG C, is incubated 40-45min, then decoct 2- with small fire
3h, the dregs of a decoction are filtered off, 2-8min is centrifuged under 300-400r/min using centrifuge, takes supernatant, be cooled to 8-10 DEG C, then will
Supernatant mixes with glycerine, adds surfactant and is well mixed, then add sodium acid carbonate, is well mixed.
Embodiment 1：A kind of thimerosal of medical apparatus sterilizing, the mass fraction of each component of the thimerosal are：Folium eucalypti
Oily 16 parts, 5 parts of kuh-seng, 6 parts of honeysuckle, 6 parts of the bark of official magnolia, 5.5 parts of radix glycyrrhizae, 5 parts of Asiatic plantain, 3 parts of HERBA VERONICAE DILATATAE, 72 parts of crab, radix scutellariae
1 part, 10 parts of cordate houttuynia, 10 parts of Chinese prickly ash, anistree 6 parts, 10 parts of ginger, 3 parts of radix bupleuri, coptis 2-4 parts, peppermint 5,3 parts of Ligusticum wallichii, granatum
2 parts, 8 parts of chrysanthemum, 3 parts of madder, 6 parts of frutus cnidii, 12 parts of glycerine, 2 parts of sodium acid carbonate, 3.5 parts of surfactant.
A kind of preparation technology of the thimerosal of above-mentioned medical apparatus sterilizing, the technique specifically include following steps：
Step 1：By kuh-seng, honeysuckle, the bark of official magnolia, radix glycyrrhizae, Asiatic plantain, HERBA VERONICAE DILATATAE, crab seven, radix scutellariae, cordate houttuynia, Chinese prickly ash,
Anise, ginger, radix bupleuri, the coptis, peppermint, Ligusticum wallichii, granatum, chrysanthemum, madder, frutus cnidii mix in proportion, dry, pulverize to
300 mesh powder；
Step 2：The powder that step 1 is prepared is with deionized water according to 2:9 ratios mix, and are persistently stirred with 200 rotating speeds
Mix 24h, be added in container, be then heated to 115 DEG C, be incubated 45min, then 2.5h is decocted with small fire, filter off the dregs of a decoction, using from
Scheming centrifuges 6min under 400r/min, takes supernatant, is cooled to 9 DEG C, then mixes supernatant with glycerine, adds surface and lives
Property agent be well mixed, then add sodium acid carbonate, be well mixed.
Embodiment 2：A kind of thimerosal of medical apparatus sterilizing, the mass fraction of each component of the thimerosal are：
18 parts of eucalyptus oil, 8 parts of kuh-seng, 9 parts of honeysuckle, 8 parts of the bark of official magnolia, 7.5 parts of radix glycyrrhizae, 6.8 parts of Asiatic plantain, HERBA VERONICAE DILATATAE 5.4
Part, 7 3.9 parts of crab, 3 parts of radix scutellariae, 12 parts of cordate houttuynia, 12 parts of Chinese prickly ash, anistree 8 parts, ginger 10-12 parts, 5 parts of radix bupleuri, 4 parts of the coptis,
Peppermint 8,8 parts of Ligusticum wallichii, 5 parts of granatum, 12 parts of chrysanthemum, 8 parts of madder, 8 parts of frutus cnidii, 15 parts of glycerine, 3 parts of sodium acid carbonate, surface
Activating agent 4.5.A kind of preparation technology of the thimerosal of above-mentioned medical apparatus sterilizing, the technique specifically include following steps：
Step 1：By kuh-seng, honeysuckle, the bark of official magnolia, radix glycyrrhizae, Asiatic plantain, HERBA VERONICAE DILATATAE, crab seven, radix scutellariae, cordate houttuynia, Chinese prickly ash,
Anise, ginger, radix bupleuri, the coptis, peppermint, Ligusticum wallichii, granatum, chrysanthemum, madder, frutus cnidii mix in proportion, dry, pulverize to
100 mesh powder；
Step 2：The powder that step 1 is prepared is with deionized water according to 5:13 ratios mix, and are persistently stirred with 200 rotating speeds
Mix 20h, be added in container, be then heated to 1120 DEG C, be incubated 45min, then 3h is decocted with small fire, filter off the dregs of a decoction, using from
Scheming centrifuges 8min under 400r/min, takes supernatant, is cooled to 10 DEG C, then mixes supernatant with glycerine, adds surface
Activating agent is well mixed, and then adds sodium acid carbonate, is well mixed.
Embodiment 3：
A kind of thimerosal of medical apparatus sterilizing, the mass fraction of each component of the thimerosal are：
18 parts of eucalyptus oil, 8 parts of kuh-seng, 9 parts of honeysuckle, 8 parts of the bark of official magnolia, 7.5 parts of radix glycyrrhizae, 6.8 parts of Asiatic plantain, HERBA VERONICAE DILATATAE 5.4
Part, 7 3.9 parts of crab, 3 parts of radix scutellariae, 12 parts of cordate houttuynia, 12 parts of Chinese prickly ash, anistree 8 parts, ginger 10-12 parts, 5 parts of radix bupleuri, 4 parts of the coptis,
Peppermint 8,8 parts of Ligusticum wallichii, 5 parts of granatum, 12 parts of chrysanthemum, 8 parts of madder, 8 parts of frutus cnidii, 15 parts of glycerine, 3 parts of sodium acid carbonate, surface
Activating agent 4.5.
A kind of preparation technology of the thimerosal of above-mentioned medical apparatus sterilizing, the technique specifically include following steps：
Step 1：By kuh-seng, honeysuckle, the bark of official magnolia, radix glycyrrhizae, Asiatic plantain, HERBA VERONICAE DILATATAE, crab seven, radix scutellariae, cordate houttuynia, Chinese prickly ash,
Anise, ginger, radix bupleuri, the coptis, peppermint, Ligusticum wallichii, granatum, chrysanthemum, madder, frutus cnidii mix in proportion, dry, pulverize to
100 mesh powder；
Step 2：The powder that step 1 is prepared is with deionized water according to 5:9 ratios mix, and are persistently stirred with 150 rotating speeds
12h is mixed, is added in container, is then heated to 100 DEG C, is incubated 40min, then 2h is decocted with small fire, the dregs of a decoction is filtered off, uses centrifugation
Machine centrifuges 3min under 300r/min, takes supernatant, is cooled to 8 DEG C, then mixes supernatant with glycerine, adds surface-active
Agent is well mixed, and then adds sodium acid carbonate, is well mixed.
Claims (7)
1. a kind of sterilization method of medicine equipment, it is characterised in that specifically include following steps：
Step 1：Used apparatus is disassembled first；
Step 2：By thimerosal and water according to 1：5 ratio is diluted, and the sterilization after dilution is carried out into mist by atomising device
Change, the part of the apparatus after dismounting is placed in into nebulization region carries out disinfection processing；
Step 3：Device element after carrying out disinfection is moved between ozonization and carries out secondary sterilization and drying；
Step 4：It will be assembled, and overhauled under pollution-free environment by the apparatus disinfected twice；
Step 5：The apparatus assembled is packed with plastic bag sealing, is sent into storehouse.
2. the sterilization method of medicine equipment according to claim 1, it is characterised in that each component of described thimerosal
Mass fraction is：
Eucalyptus oil 15-20, kuh-seng 4-8 parts, honeysuckle 5-9 parts, bark of official magnolia 6-8 parts, radix glycyrrhizae 5.5-7.5 parts, Asiatic plantain 4.2-6.8
Part, HERBA VERONICAE DILATATAE 2.2-5.4 parts, the 1.6-3.9 parts of crab seven, radix scutellariae 1-3 parts, cordate houttuynia 10-12 parts, Chinese prickly ash 9-12 parts, anistree 6-8
Part, ginger 10-12 parts, radix bupleuri 3-5 parts, coptis 2-4 parts, peppermint 5-8, Ligusticum wallichii 3-8 parts, granatum 1-5 parts, chrysanthemum 8-12 parts, madder
Careless 3-8 parts, frutus cnidii 6-8 parts, glycerine 10-15 parts, sodium acid carbonate 2-3 parts, surfactant 3-5 parts.
3. the sterilization method of medicine equipment according to claim 2, it is characterised in that the quality of each component of the thimerosal
Number is：
Eucalyptus oil 16-18 parts, kuh-seng 5-6 parts, honeysuckle 6-7 parts, bark of official magnolia 6-8 parts, radix glycyrrhizae 5.5-7.5 parts, Asiatic plantain 5-6 parts,
HERBA VERONICAE DILATATAE 3-4 parts, the 2-3.5 parts of crab seven, radix scutellariae 1-3 parts, cordate houttuynia 10-12 parts, Chinese prickly ash 10-11 parts, anistree 6-8 parts, ginger 10-
12 parts, radix bupleuri 3-5 parts, coptis 2-4 parts, peppermint 5-8, Ligusticum wallichii 3-8 parts, granatum 2-4 parts, chrysanthemum 8-12 parts, madder 3-8 parts,
Frutus cnidii 6-8 parts, glycerine 12-13 parts, sodium acid carbonate 2-3 parts, surfactant 3.5-4.5 parts.
4. the thimerosal of the medical apparatus sterilizing according to Claims 2 or 3, it is characterised in that each group of the thimerosal
Point mass fraction be：16 parts of eucalyptus oil, 5 parts of kuh-seng, 6 parts of honeysuckle, 6 parts of the bark of official magnolia, 5.5 parts of radix glycyrrhizae, 5 parts of Asiatic plantain, water is climing
Blue or green 3 parts, 72 parts of crab, 1 part of radix scutellariae, 10 parts of cordate houttuynia, 10 parts of Chinese prickly ash, anistree 6 parts, 10 parts of ginger, 3 parts of radix bupleuri, coptis 2-4 parts,
Peppermint 5,3 parts of Ligusticum wallichii, 2 parts of granatum, 8 parts of chrysanthemum, 3 parts of madder, 6 parts of frutus cnidii, 12 parts of glycerine, 2 parts of sodium acid carbonate, surface are lived
Property agent 3.5.
5. the thimerosal of the medical apparatus sterilizing according to Claims 2 or 3, it is characterised in that each group of the thimerosal
Point mass fraction be：
18 parts of eucalyptus oil, 8 parts of kuh-seng, 9 parts of honeysuckle, 8 parts of the bark of official magnolia, 7.5 parts of radix glycyrrhizae, 6.8 parts of Asiatic plantain, 5.4 parts of HERBA VERONICAE DILATATAE, crab
7 3.9 parts of crab, 3 parts of radix scutellariae, 12 parts of cordate houttuynia, 12 parts of Chinese prickly ash, anistree 8 parts, ginger 10-12 parts, 5 parts of radix bupleuri, 4 parts of the coptis, peppermint
8th, 8 parts of Ligusticum wallichii, 5 parts of granatum, 12 parts of chrysanthemum, 8 parts of madder, 8 parts of frutus cnidii, 15 parts of glycerine, 3 parts of sodium acid carbonate, surface-active
4.5 parts of agent.
6. according to the thimerosal of medical apparatus sterilizing described in claim 2-5 any one claims, it is characterised in that institute
It is anion surfactant LAS or K12 to state surfactant.
7. according to the preparation technology of the thimerosal of medical apparatus sterilizing described in claim 2-5 any one claims, its
It is characterised by, the technique specifically includes following steps：
Step 1：By kuh-seng, honeysuckle, the bark of official magnolia, radix glycyrrhizae, Asiatic plantain, HERBA VERONICAE DILATATAE, crab seven, radix scutellariae, cordate houttuynia, Chinese prickly ash, anise,
Ginger, radix bupleuri, the coptis, peppermint, Ligusticum wallichii, granatum, chrysanthemum, madder, frutus cnidii mix in proportion, and dry, pulverize to 100-
300 mesh powder；
Step 2：The powder that step 1 is prepared is with deionized water according to 2-5:9-13 ratios mix, and are held with 100-200 rotating speeds
Continuous stirring 12-24h, is added in container, is then heated to 100-120 DEG C, is incubated 40-45min, then decocts 2-3h with small fire,
The dregs of a decoction are filtered off, 2-8min is centrifuged under 300-400r/min using centrifuge, takes supernatant, be cooled to 8-10 DEG C, then will be upper
Clear liquid mixes with glycerine, adds surfactant and is well mixed, then add sodium acid carbonate and eucalyptus oil, is well mixed.
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Application publication date: 20180119 |
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