CN107582613A - One seed ginseng stilbene chewable tablets and preparation method thereof - Google Patents
One seed ginseng stilbene chewable tablets and preparation method thereof Download PDFInfo
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- CN107582613A CN107582613A CN201710831638.3A CN201710831638A CN107582613A CN 107582613 A CN107582613 A CN 107582613A CN 201710831638 A CN201710831638 A CN 201710831638A CN 107582613 A CN107582613 A CN 107582613A
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- chewable tablets
- ginseng stilbene
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- radix astragali
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Abstract
The invention provides a seed ginseng stilbene chewable tablets, raw material includes Radix Codonopsis, the Radix Astragali, rock sugar and auxiliary material.Its preparation method is first to add water to cook Radix Codonopsis, the Radix Astragali, fine powder and rock sugar, auxiliary materials and mixing obtained by being spray-dried after water decoction concentration, granulation, tabletting, is produced.Instant invention overcomes it is existing ginseng stilbene soft extract quality stability it is poor, be not easy to store the shortcomings that, medicament contg is accurate, stability is high, carrying it is convenient to take, mouthfeel is good.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to seed ginseng stilbene chewable tablets and preparation method thereof.
Background technology
Ginseng stilbene cream is made up of Radix Codonopsis and the Radix Astragali through decocting, and has the effect of reinforcing the spleen to benefit the lung, available for spleen-lung Qi deficiency, easily
Breathe heavily weary, weakness of limbs, deficiency of food is indigestion and loss of appetite, diarrhea with loose stool.
At present, the preparation method for joining stilbene cream is collecting decoction after adding water to cook Radix Codonopsis, the Radix Astragali three times, is filtered, and filtrate is dense
Shorten the clear cream of relative density 1.20 (20 DEG C) into；Separately take rock sugar, preservative, add clear cream appropriate, stirring make it is molten, filtration, add
Remaining clear cream, is stirred evenly, and is condensed into relative density 1.34 (20 DEG C), is produced.The obtained ginseng stilbene cream product stability of prior art is poor,
It is not easy to store, medicament contg is inaccurate, and inconvenience is taken in carrying, and Con trolling index is low in quality index, and no key component contains
Amount control.
The content of the invention
It is an object of the invention to provide seed ginseng stilbene chewable tablets and preparation method thereof, the ginseng stilbene chewable tablets steady quality, medicine
Thing content is accurate, and carrying is convenient to take, and mouthfeel is good.
The technical solution adopted by the present invention is as follows：
One seed ginseng stilbene chewable tablets, including the following raw material by weight：100~200 parts of Radix Codonopsis, the Radix Astragali 120~210
Part, 50~100 parts of rock sugar, 10~20 parts of auxiliary material.
Preferably, the auxiliary material is one or more of mixing in mannitol, PVP K30, starch or PEG4000
Thing.
The preparation method of above-mentioned ginseng stilbene chewable tablets, comprises the following steps：
Step 1, Radix Codonopsis, the Radix Astragali are added water to cook three times, the 1st, 2 time each 2 hours, the 3rd time 1 hour, water consumption is respectively
10 times, 8 times, 8 times of medicinal material weight, collecting decoction, filtration, filtrate are condensed into the clear cream of 5 ° of Be (80 DEG C), precipitate 24 hours, filter
Supernatant is taken, is concentrated into the clear cream of 18 ° of Be (80 DEG C)；
Step 2, fine powder is made by step 1 gained clear cream is spray-dried；
Step 3, by step 2 gained fine powder and rock sugar, auxiliary materials and mixing, granulation；
Step 4, by step 3 gained granulation, produce.
Preferably, spray dryer inlet temperature is 170~205 DEG C in step 2, and outlet temperature is 85~105 DEG C.
Join stilbene chewable tablets because of its chewable tablets, while soft extract help curative effect is retained, because of its steady quality, medicament contg
Accurately, patient when in use, can accurately control taking dose.
Compared with prior art, its advantage is the present invention：(1) ginseng stilbene chewable tablets amount of the invention is stable, and medicine contains
Amount is accurate, and patient when in use, can accurately control taking dose.(2) this product remains soft extract help curative effect, meanwhile, take
With convenient to take, mouthfeel is good.
Product specification of the present invention is 0.33g/ pieces, two times a day, one time 3, every containing the Radix Astragali with Astragaloside IV
(C41H68O14) meter, it should must not be less than 0.26mg.With the effect that reinforces the spleen to benefit the lung.For spleen-lung Qi deficiency, weary, weakness of limbs is breathed heavily easily,
Deficiency of food is indigestion and loss of appetite, diarrhea with loose stool.
Embodiment
The present invention is further described in detail below by specific embodiment, but is not limited to this.
Embodiment 1
One seed ginseng stilbene chewable tablets, including the following raw material by weight：100 parts of Radix Codonopsis, 100 parts of the Radix Astragali, 50 parts of rock sugar,
10 parts of starch, 2 parts of PEG4000.
Its preparation method, comprise the following steps：
Step 1, Radix Codonopsis, the Radix Astragali are added water to cook three times, the 1st, 2 time each 2 hours, the 3rd time 1 hour, water consumption is respectively
10 times, 8 times, 8 times of medicinal material weight, collecting decoction, filtration, filtrate are condensed into the clear cream of 5 ° of Be (80 DEG C), precipitate 24 hours, filter
Supernatant is taken, is concentrated into the clear cream that mother-in-law U.S. degree is about 18 ° of Be (80 DEG C), it is standby；
Step 2, dry：Clear cream is spray dried to fine powder.Spray dryer inlet temperature is 175 DEG C, and outlet temperature is
It is 95 DEG C, standby；
Step 3, by spray dried powder and rock sugar add starch, PEG4000 mix, be made can tabletting particle；
Step 4, by granulation, punch dieScrobicula, average piece weight was checked once every 15 minutes in tableting processes,
Check hardness, outward appearance etc. simultaneously.
The present embodiment product every is containing the Radix Astragali with Astragaloside IV (C41H68O14) meter, it is 0.34mg.
Embodiment 2
One seed ginseng stilbene chewable tablets, including the following raw material by weight：150 parts of Radix Codonopsis, 160 parts of the Radix Astragali, 80 parts of rock sugar,
5 parts of mannitol, 2 parts of PVP K30,8 parts of starch.
Its preparation method, comprise the following steps：
Step 1, Radix Codonopsis, the Radix Astragali are added water to cook three times, the 1st, 2 time each 2 hours, the 3rd time 1 hour, water consumption is respectively
10 times, 8 times, 8 times of medicinal material weight, collecting decoction, filtration, filtrate are condensed into the clear cream of 5 ° of Be (80 DEG C), precipitate 24 hours, filter
Supernatant is taken, is concentrated into the clear cream that mother-in-law U.S. degree is about 18 ° of Be (80 DEG C), it is standby；
Step 2, dry：Clear cream is spray dried to fine powder.Spray dryer inlet temperature is 185 DEG C, and outlet temperature is
It is 90 DEG C, standby；
Step 3, by spray dried powder and rock sugar add mannitol, PVP K30, starch mix, be made can tabletting particle；
Step 4, by granulation, punch dieScrobicula, average piece weight was checked once every 15 minutes in tableting processes,
Check hardness, outward appearance etc. simultaneously.
The present embodiment product every is containing the Radix Astragali with Astragaloside IV (C41H68O14) meter, it is 0.31mg.
Embodiment 3
One seed ginseng stilbene chewable tablets, including the following raw material by weight：180 parts of Radix Codonopsis, 190 parts of the Radix Astragali, 90 parts of rock sugar,
4 parts of PVP K30,12 parts of starch.
Its preparation method, comprise the following steps：
Step 1, Radix Codonopsis, the Radix Astragali are added water to cook three times, the 1st, 2 time each 2 hours, the 3rd time 1 hour, water consumption is respectively
10 times, 8 times, 8 times of medicinal material weight, collecting decoction, filtration, filtrate are condensed into the clear cream of 5 ° of Be (80 DEG C), precipitate 24 hours, filter
Supernatant is taken, is concentrated into the clear cream that mother-in-law U.S. degree is about 18 ° of Be (80 DEG C), it is standby；
Step 2, dry：Clear cream is spray dried to fine powder.Spray dryer inlet temperature is 185 DEG C, and outlet temperature is
It is 90 DEG C, standby；
Step 3, by spray dried powder and rock sugar add PVP K30, starch mix, be made can tabletting particle；
Step 4, by granulation, punch dieScrobicula, average piece weight was checked once every 15 minutes in tableting processes,
Check hardness, outward appearance etc. simultaneously.
The present embodiment product every is containing the Radix Astragali with Astragaloside IV (C41H68O14) meter, it is 0.32mg.
Stability test is carried out to embodiment 1~3, result of the test is as shown in table 1~3.
Claims (5)
- A 1. seed ginseng stilbene chewable tablets, it is characterised in that：Including the following raw material by weight：100~200 parts of Radix Codonopsis, the Radix Astragali 120~210 parts, 50~100 parts of rock sugar, 10~20 parts of auxiliary material.
- 2. ginseng stilbene chewable tablets according to claim 1, it is characterised in that：The auxiliary material is mannitol, PVP class 30, formed sediment One or more of mixtures in powder, PEG4000.
- 3. the preparation method of the ginseng stilbene chewable tablets described in claim 1, it is characterised in that：Comprise the following steps：Step 1, Radix Codonopsis, the Radix Astragali are added water to cook three times, collecting decoction, filtered, filtrate is condensed into 80 DEG C of 5 ° of Be clear cream, precipitates 24 hours, leaching supernatant, it is concentrated into 80 DEG C of 18 ° of Be clear cream；Step 2, fine powder is made by step 1 gained clear cream is spray-dried；Step 3, by step 2 gained fine powder and rock sugar, auxiliary materials and mixing, granulation；Step 4, by step 3 gained granulation, produce.
- 4. the preparation method of ginseng stilbene chewable tablets according to claim 3, it is characterised in that：Radix Codonopsis, the Radix Astragali are added in step 1 The the 1st, 2 time each 2 hours three times are boiled in decocting, and the 3rd time 1 hour, water consumption was respectively 10 times, 8 times, 8 times of medicinal material weight.
- 5. the preparation method of ginseng stilbene chewable tablets according to claim 3, it is characterised in that：Spray dryer enters in step 2 Mouth temperature is 170~205 DEG C, and outlet temperature is 85~105 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710831638.3A CN107582613A (en) | 2017-09-14 | 2017-09-14 | One seed ginseng stilbene chewable tablets and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710831638.3A CN107582613A (en) | 2017-09-14 | 2017-09-14 | One seed ginseng stilbene chewable tablets and preparation method thereof |
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| CN107582613A true CN107582613A (en) | 2018-01-16 |
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| CN201710831638.3A Pending CN107582613A (en) | 2017-09-14 | 2017-09-14 | One seed ginseng stilbene chewable tablets and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602890A (en) * | 2018-12-28 | 2019-04-12 | 山西兰花太行中药有限公司 | A kind of Radix Codonopsis chewable tablets and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550630A (en) * | 2013-11-08 | 2014-02-05 | 山东阿如拉药物研究开发有限公司 | Medlar thirst-eliminating chewable tablet as well as preparation method and application thereof |
| CN106176901A (en) * | 2016-08-25 | 2016-12-07 | 刘根喜 | A kind of astragalus chewable tablets and preparation method thereof |
-
2017
- 2017-09-14 CN CN201710831638.3A patent/CN107582613A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550630A (en) * | 2013-11-08 | 2014-02-05 | 山东阿如拉药物研究开发有限公司 | Medlar thirst-eliminating chewable tablet as well as preparation method and application thereof |
| CN106176901A (en) * | 2016-08-25 | 2016-12-07 | 刘根喜 | A kind of astragalus chewable tablets and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郑美凤: "《中医名家谈秋季养生》", 30 June 2000, 上海中医药大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602890A (en) * | 2018-12-28 | 2019-04-12 | 山西兰花太行中药有限公司 | A kind of Radix Codonopsis chewable tablets and preparation method thereof |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180116 |
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| RJ01 | Rejection of invention patent application after publication |