CN105582299A - Traditional Chinese medicine composition for treating diabetes mellitus - Google Patents

Traditional Chinese medicine composition for treating diabetes mellitus Download PDF

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CN105582299A
CN105582299A CN201610107984.2A CN201610107984A CN105582299A CN 105582299 A CN105582299 A CN 105582299A CN 201610107984 A CN201610107984 A CN 201610107984A CN 105582299 A CN105582299 A CN 105582299A
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parts
medicine composition
chinese medicine
radix
diabetes
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朱怀安
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

The invention relates to a traditional Chinese medicine composition for treating diabetes mellitus. The traditional Chinese medicine composition is prepared from the following substances in parts by weight: 25 parts of puerarin, 20 parts of rhizoma anemarrhenae, 25 parts of radix trichosanthis, 12 parts of coptis chinensis, 60 parts of dried rehamnnia roots, 20 parts of hairyvein agrimony, 25 parts of radix polygonati officinalis, 20 parts of polygonatum kingianum, 20 parts of wolfberries, 20 parts of mulberry leaves, 30 parts of common yam rhizome, 15 parts of scrophularia ningpoensis, 25 parts of astragalus membranaceus, 30 parts of gypsum, 20 parts of white peony roots, 15 parts of jujube kernel, 15 parts of ganoderma lucidum, 20 parts of codonopsis pilosula, 15 parts of salviae miltiorrhizae, 12 parts of schisandra chinensis, 12 parts of rhizoma atractylodis, 12 parts of rhizoma atractylodis macrocephalae, 15 parts of chinemys reevesii, 30 parts of hawthorn, 15 parts of pulp of cornus and 30 parts of radix pseudostellariae. According to the traditional Chinese medicine composition provided by the invention, scientific and reasonable combination can be carried out according to the principles of 'monarch, minister, assistant and guide'; the traditional Chinese medicine composition has the effects of invigorating the spleen, supplementing qi, warming yin and tonifying the kidneys, and is capable of effectively reducing blood sugar and blood fat of a patient and reducing or relieving complications after being taken by people with diabetes.

Description

A kind of Chinese medicine composition for the treatment of diabetes
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of Chinese medicine composition for the treatment of diabetes.
Background technology
Diabetes are one of the world's three large difficult and complicated illness, and in decades, countries in the world have been carried out long-term and unremitting grinding one after anotherStudy carefully and exploitation. in treatment diabetes history, there is twice important breakthrough: be the 1950's for the first time, first Chinese is artificialInsulin synthesis, makes a stir all over the world; Be the appearance of biguanides and sulfonylureas OHA for the second time, make diabetic's blood sugarBe able to temporary transient control. reach tens of kinds for clinical treatment Chinese and Western medicine used at present, but due to diabetes pathology, the cause of disease are groundStudy carefully and also there is no so far substantial breakthrough, treatment diabetes still increase the stage and prevent comprehensively concurrent in control blood sugar, glucose in urineThe conceptual phase of disease. in addition, patient's long-term taking Western medicine, can bring side effect to internal organs such as kidney, liver, the heart, spleen, stomaches. and therefore, existingThere is technology to need further improvement and develop.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of diabetes.
In order to realize object of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of diabetes, it comprises followingThe material of weight portion: 25 parts of the roots of kudzu vine, 20 parts of the wind-weeds, 25 parts of roots of Chinese trichosanthes, 12 parts of the coptiss, 60 parts of radix rehmanniae recens, 20 parts of hairyvein agrimonies, radix polygonati officinalis25 parts, 20 parts of sealworts, 20 parts of structure Qis, 20 parts, mulberry leaf, 30 parts of Chinese yam rhizomes, 15 parts of radix scrophulariaes, 25 parts of the Radixs Astragali, 30 parts, gypsum, the root of herbaceous peony 20Part, 15 parts of jujube kernels, 15 parts of glossy ganodermas, 20 parts of Radix Codonopsis, 15 parts of the reds sage root, 12 parts, the fruit of Chinese magnoliavine, 12 parts of rhizoma atractylodis, 12 parts of the bighead atractylodes rhizomes, Colla Plastri Testudinis 1530 parts of part, 30 parts of hawthorn, 15 parts of dogwood fruits and radix pseudostellariaes.
Preferably, the Chinese medicine composition for the treatment of diabetes of the present invention also comprises the material of following weight portion: 0.1 partThe material with following structural:
More preferably, described Chinese medicine composition can be lotion, ointment or pulvis.
The present invention also provides the purposes of the material with following structural in the medicine of preparation treatment diabetes:
The present invention also provides the purposes of the material with following structural in the medicine of preparation treatment diabetes B:
Chinese medicine composition of the present invention can carry out scientific and reasonable compatibility according to the principle of " monarch ", hasStrengthening the spleen and replenishing qi, the effect of warm cloudy kidney tonifying, after diabetic takes, can effectively reduce patient's blood sugar, blood fat, reduces or alleviatesComplication.
Detailed description of the invention
Further illustrate the present invention below by embodiment. It should be understood that embodiments of the invention are for explanationThe present invention instead of limitation of the present invention. the simple modifications that essence according to the present invention is carried out the present invention all belongs to the present inventionClaimed scope. except as otherwise noted, otherwise percentage in the present invention is percetage by weight.
Embodiment 1
Take 25 grams of the roots of kudzu vine, 20 grams of the wind-weeds, 25 grams of roots of Chinese trichosanthes, 12 grams of the coptiss, 60 grams of radix rehmanniae recens, 20 grams of hairyvein agrimonies, radix polygonati officinalis25 grams, 20 grams of sealworts, 20 grams of matrimony vines, 20 grams, mulberry leaf, 30 grams of Chinese yam rhizomes, 15 grams of radix scrophulariaes, 25 grams of the Radixs Astragali, 30 grams, gypsum, the root of herbaceous peony 20Gram, 15 grams of jujube kernels, 15 grams of glossy ganodermas, 20 grams of Radix Codonopsis, 15 grams of the reds sage root, 12 grams, the fruit of Chinese magnoliavine, 12 grams of rhizoma atractylodis, 12 grams of the bighead atractylodes rhizomes, Colla Plastri Testudinis 15Gram, 30 grams of 30 grams of hawthorn, 15 grams of dogwood fruits and radix pseudostellariaes, pulverize, cross 100 mesh sieves and get final product.
Embodiment 2
Compound has following structural:
Test example
Diabetes B Establishment of Rat Model
SPF level SD male rat, body weight (140 ± 10) g, feeding environment temperature is 20-25 DEG C, relative humidity 50%-60%, 12/12h round the clock rule feeds. conventional raising 1 week, then separate at random normal group, and 10 animals of normal group, give generalLogical feed, other animals give high lipid food. and high lipid food is purchased from Beijing HFK Bio-Technology Co., Ltd., SCXK(capital) 2009-0004, maintains feedstuff composition by lard, yolk powder, sucrose, basis.
Buffer preparation: the citric acid-sodium citrate buffer of preparation pH4.4-4.6, approximately every 100ml cushioning liquidIn contain 1.07g citric acid and 1.44g natrium citricum, 4 DEG C save backup;
1% Streptozotocin (STZ) preparation: use above-mentioned cushioning liquid, be dissolved in 100ml cushioning liquid by 1gSTZ and joinSystem, matching while using, lucifuge, low-temperature operation;
STZ prerun: during high fat is fed, make in advance with STZ dosage 25mg/kg, 30mg/kg, 35mg/kg, 40mg/kgMould, the optimal dosage that is specified to mould is 30mg/kg;
Injection STZ: high fat is fed 8 weeks, and fasting is after 12 hours, and high fat group rat gives lumbar injection by STZ30mg/kg, 6After hour, supplementary 5% G/W 12 hours, changes thereafter with light water;
Blood sugar test: after one week, adopt Abbott Laboratories' blood glucose meter and supporting blood sugar test paper, to the fasting overnight high fat of 10 hoursGroup rat fasting blood-glucose value detects, if blood glucose value >=11.1mmol/L is modeling success;
Complement SZT: the rat that fasting blood-glucose is not reached to 11.1mmol/L carries out complement STZ, after one week, if blood glucose value >=11.1mmol/L, Cheng Mo enters group, does not reach person yet, gives up.
According to fasting blood sugar with body weight to becoming mould rat to carry out random packet, be divided into five groups, 10 every group, the equal nothing of body weightSignificant difference (P > 0.05): respectively group dosage is as follows for normal group, model group, administration group 1, administration group 2, administration group 3.: normalGroup and model group, give physiological saline gavage 1mL/100g body weight; Administration group 1, the powder 10g of embodiment 1 adds 1000mL physiologySalt solution is mixed with suspension, gives gavage 1mL/100g body weight; Administration group 2, the compound of 0.01g adds 1000mL physiological saline and joinsMake suspension, give gavage 1mL/100g body weight; Administration group 3, the powder 5g of embodiment 1 and the compound of 0.005g add1000mL physiological saline is mixed with suspension, gives gavage 1mL/100g body weight .1 times/day, and successive administration records blood glucose value for 6 weeks,The results are shown in following table.
Group Blood glucose value (mmol/L)
Normal group 5.81±1.16 2 -->
Model group 18.17±1.81
Administration group 1 12.62±1.52
Administration group 2 9.61±0.97
Administration group 3 10.85±1.13
As seen from the above table, through treatment, the blood glucose value of administration group all declines with respect to model group.

Claims (5)

1. a Chinese medicine composition for the treatment of diabetes, is characterized in that, the material that it comprises following weight portion: 25 parts of the roots of kudzu vine,20 parts of the wind-weeds, 25 parts of roots of Chinese trichosanthes, 12 parts of the coptiss, 60 parts of radix rehmanniae recens, 20 parts of hairyvein agrimonies, 25 parts of radix polygonati officinalis, 20 parts of sealworts, matrimony vine 20Part, 20 parts, mulberry leaf, 30 parts of Chinese yam rhizomes, 15 parts of radix scrophulariaes, 25 parts of the Radixs Astragali, 30 parts, gypsum, 20 parts of the root of herbaceous peonys, 15 parts of jujube kernels, 15 parts of glossy ganodermas,20 parts of Radix Codonopsis, 15 parts of the reds sage root, 12 parts, the fruit of Chinese magnoliavine, 12 parts of rhizoma atractylodis, 12 parts of the bighead atractylodes rhizomes, 15 parts of Colla Plastri Testudinis, 30 parts of hawthorn, 15 parts of dogwood fruitsWith 30 parts of radix pseudostellariaes.
2. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that, it also comprises following weight portionMaterial: the material with following structural of 0.1 part:
。
3. the Chinese medicine composition for the treatment of diabetes according to claim 3, is characterized in that, described Chinese medicine composition is passableLotion, ointment or pulvis.
4. the purposes of the material with following structural in the medicine of preparation treatment diabetes:
。
5. the purposes of the material with following structural in the medicine of preparation treatment diabetes B:
。
CN201610107984.2A 2016-02-29 2016-02-29 Traditional Chinese medicine composition for treating diabetes mellitus Pending CN105582299A (en)

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CN107898914A (en) * 2018-01-09 2018-04-13 王道繁 A kind of tea bag for prophylactic treatment diabetes and preparation method thereof
CN108403951A (en) * 2018-05-24 2018-08-17 大连根特生物工程技术有限公司 A method of utilizing cordyceps fermenting and producing hypoglycemic health-care product
CN108853380A (en) * 2018-09-28 2018-11-23 周天元 The pharmaceutical composition and its preparation method and application for treating diabetes

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* Cited by examiner, † Cited by third party
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CN107898914A (en) * 2018-01-09 2018-04-13 王道繁 A kind of tea bag for prophylactic treatment diabetes and preparation method thereof
CN108403951A (en) * 2018-05-24 2018-08-17 大连根特生物工程技术有限公司 A method of utilizing cordyceps fermenting and producing hypoglycemic health-care product
CN108853380A (en) * 2018-09-28 2018-11-23 周天元 The pharmaceutical composition and its preparation method and application for treating diabetes
CN108853380B (en) * 2018-09-28 2021-04-13 周天元 Pharmaceutical composition for treating diabetes and preparation method and application thereof

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