CN107580596B - 用于治疗和预防病毒感染的新的磺亚氨酰基嘌呤酮化合物和衍生物 - Google Patents

用于治疗和预防病毒感染的新的磺亚氨酰基嘌呤酮化合物和衍生物 Download PDF

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Publication number
CN107580596B
CN107580596B CN201680026493.3A CN201680026493A CN107580596B CN 107580596 B CN107580596 B CN 107580596B CN 201680026493 A CN201680026493 A CN 201680026493A CN 107580596 B CN107580596 B CN 107580596B
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purin
methyl
amino
compound
oxo
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Chinese (zh)
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CN107580596A (zh
Inventor
梁春根
苗坤
王剑平
贠红英
郑秀芳
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680026493.3A 2015-05-08 2016-05-04 用于治疗和预防病毒感染的新的磺亚氨酰基嘌呤酮化合物和衍生物 Active CN107580596B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2015078507 2015-05-08
CNPCT/CN2015/078507 2015-05-08
CN2016078785 2016-04-08
CNPCT/CN2016/078785 2016-04-08
PCT/EP2016/059961 WO2016180695A1 (en) 2015-05-08 2016-05-04 Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection

Publications (2)

Publication Number Publication Date
CN107580596A CN107580596A (zh) 2018-01-12
CN107580596B true CN107580596B (zh) 2020-07-14

Family

ID=55910966

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CN201680026493.3A Active CN107580596B (zh) 2015-05-08 2016-05-04 用于治疗和预防病毒感染的新的磺亚氨酰基嘌呤酮化合物和衍生物

Country Status (32)

Country Link
US (3) US9708325B2 (OSRAM)
EP (1) EP3294740B1 (OSRAM)
JP (1) JP6738352B2 (OSRAM)
KR (1) KR102690131B1 (OSRAM)
CN (1) CN107580596B (OSRAM)
AR (1) AR104528A1 (OSRAM)
AU (3) AU2016260683B2 (OSRAM)
BR (1) BR112017023959B1 (OSRAM)
CA (1) CA2982704C (OSRAM)
CL (1) CL2017002745A1 (OSRAM)
CO (1) CO2017009994A2 (OSRAM)
CR (1) CR20170496A (OSRAM)
DK (1) DK3294740T3 (OSRAM)
ES (1) ES2753777T3 (OSRAM)
HR (1) HRP20191942T1 (OSRAM)
HU (1) HUE045906T2 (OSRAM)
IL (2) IL254947B (OSRAM)
LT (1) LT3294740T (OSRAM)
MX (2) MX393198B (OSRAM)
MY (1) MY182353A (OSRAM)
NZ (2) NZ775222A (OSRAM)
PE (1) PE20171620A1 (OSRAM)
PH (1) PH12017502009A1 (OSRAM)
PL (1) PL3294740T3 (OSRAM)
PT (1) PT3294740T (OSRAM)
RS (1) RS59435B1 (OSRAM)
RU (1) RU2745269C2 (OSRAM)
SG (1) SG10202108841YA (OSRAM)
SI (1) SI3294740T1 (OSRAM)
TW (2) TWI706954B (OSRAM)
UA (1) UA120450C2 (OSRAM)
WO (1) WO2016180695A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ775222A (en) * 2015-05-08 2024-09-27 Hoffmann La Roche Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
IL284255B (en) 2016-08-29 2022-07-01 Hoffmann La Roche 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection
TWI720250B (zh) * 2016-09-13 2021-03-01 瑞士商赫孚孟拉羅股份公司 利用tlr7促效劑及hbv蛋白殼組裝抑制劑之組合治療
CN111699187A (zh) 2018-02-12 2020-09-22 豪夫迈·罗氏有限公司 用于治疗和预防病毒感染的新的砜化合物和衍生物
JP7089596B2 (ja) * 2018-02-28 2022-06-22 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 肝がんの治療及び予防のための７位置換スルホンイミドイルプリノン化合物及び誘導体
CN111072667A (zh) * 2018-10-22 2020-04-28 罗欣药业(上海)有限公司 五元或六元杂环并嘧啶类化合物及其用途
WO2020168017A1 (en) * 2019-02-12 2020-08-20 Ambrx, Inc. Compositions containing, methods and uses of antibody-tlr agonist conjugates
EP4031544B1 (en) 2019-09-20 2024-02-28 Syngenta Crop Protection AG Pesticidally active heterocyclic derivatives with sulfur and sulfoximine containing substituents
WO2021154662A1 (en) * 2020-01-27 2021-08-05 Bristol-Myers Squibb Company 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
JP7684316B2 (ja) * 2020-01-27 2025-05-27 ブリストル－マイヤーズ スクイブ カンパニー トール様受容体７（ＴＬＲ７）アゴニストとしての１Ｈ－ピラゾロ［４，３－ｄ］ピリミジン化合物
EP4554678A1 (en) 2022-07-14 2025-05-21 F. Hoffmann-La Roche AG Phosphorylpurinone compounds for the treatment of cancer
CN118724963A (zh) * 2023-03-30 2024-10-01 浙江养生堂天然药物研究所有限公司 含磷或含硫的大环化合物及其用途

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2006117670A1 (en) * 2005-05-04 2006-11-09 Pfizer Limited 2-amido-6-amino-8-oxopurine derivatives as toll-like receptor modulators for the treatment of cancer and viral infections, such as hepatitis c
US20100143301A1 (en) * 2008-12-09 2010-06-10 Gilead Sciences, Inc. Modulators of toll-like receptors

Family Cites Families (9)

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JP4189048B2 (ja) * 1997-12-26 2008-12-03 大日本住友製薬株式会社 複素環化合物
CN101239980B (zh) 2008-02-18 2011-06-22 靳广毅 免疫受体调节剂偶联体前体和偶联体及其应用
US20110150836A1 (en) 2009-12-22 2011-06-23 Gilead Sciences, Inc. Methods of treating hbv and hcv infection
TWI555737B (zh) 2011-05-24 2016-11-01 拜耳知識產權公司 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺
EP2776439B1 (en) * 2011-11-09 2018-07-04 Janssen Sciences Ireland UC Purine derivatives for the treatment of viral infections
BR112015024411B1 (pt) 2013-03-29 2022-02-22 Janssen Sciences Ireland Uc Desaza-purinonas macrocíclicas para o tratamento de infeções virais e composição farmacêutica que os compreende
AU2015303558B2 (en) 2014-08-15 2018-07-12 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Pyrrolopyrimidine compounds used as TLR7 agonist
NZ775222A (en) * 2015-05-08 2024-09-27 Hoffmann La Roche Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
IL284255B (en) * 2016-08-29 2022-07-01 Hoffmann La Roche 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006117670A1 (en) * 2005-05-04 2006-11-09 Pfizer Limited 2-amido-6-amino-8-oxopurine derivatives as toll-like receptor modulators for the treatment of cancer and viral infections, such as hepatitis c
US20100143301A1 (en) * 2008-12-09 2010-06-10 Gilead Sciences, Inc. Modulators of toll-like receptors

Also Published As

Publication number Publication date
IL280769B1 (en) 2023-03-01
KR20180003612A (ko) 2018-01-09
HK1247925A1 (zh) 2018-10-05
CA2982704A1 (en) 2016-11-17
SI3294740T1 (sl) 2019-12-31
TWI768467B (zh) 2022-06-21
US20200109144A1 (en) 2020-04-09
PT3294740T (pt) 2019-10-29
IL254947A0 (en) 2017-12-31
RS59435B1 (sr) 2019-11-29
CR20170496A (es) 2017-12-05
WO2016180695A1 (en) 2016-11-17
MX2020010949A (es) 2022-06-16
AU2016260683A1 (en) 2017-10-12
CA2982704C (en) 2023-10-24
AU2020256348B2 (en) 2022-06-16
CL2017002745A1 (es) 2018-05-18
MX376761B (es) 2025-03-07
US9708325B2 (en) 2017-07-18
AU2020256348A1 (en) 2020-11-12
EP3294740A1 (en) 2018-03-21
SG10202108841YA (en) 2021-09-29
ES2753777T3 (es) 2020-04-14
KR102690131B1 (ko) 2024-07-31
CO2017009994A2 (es) 2018-02-20
PH12017502009A1 (en) 2018-03-26
HRP20191942T1 (hr) 2020-01-10
TW201716410A (zh) 2017-05-16
JP6738352B2 (ja) 2020-08-12
TWI706954B (zh) 2020-10-11
TW202108584A (zh) 2021-03-01
LT3294740T (lt) 2019-11-25
US20160326177A1 (en) 2016-11-10
PE20171620A1 (es) 2017-11-02
RU2745269C2 (ru) 2021-03-22
MY182353A (en) 2021-01-20
RU2017142577A3 (OSRAM) 2019-10-31
NZ775222A (en) 2024-09-27
IL280769A (en) 2021-04-29
IL280769B2 (en) 2023-07-01
UA120450C2 (uk) 2019-12-10
NZ735648A (en) 2023-06-30
IL254947B (en) 2021-02-28
BR112017023959A2 (pt) 2018-07-17
EP3294740B1 (en) 2019-09-04
AR104528A1 (es) 2017-07-26
PL3294740T3 (pl) 2020-03-31
US20170275286A1 (en) 2017-09-28
AU2016260683B2 (en) 2020-10-29
DK3294740T3 (da) 2019-11-04
US10399983B2 (en) 2019-09-03
RU2017142577A (ru) 2019-06-10
BR112017023959B1 (pt) 2023-05-02
AU2022204666A1 (en) 2022-07-21
US11242345B2 (en) 2022-02-08
HUE045906T2 (hu) 2020-01-28
JP2018515509A (ja) 2018-06-14
MX2017014033A (es) 2018-03-01
CN107580596A (zh) 2018-01-12
MX393198B (es) 2025-03-19

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