CN107569237A - The measuring method and device of Non-invasive detection hemoglobin level - Google Patents
The measuring method and device of Non-invasive detection hemoglobin level Download PDFInfo
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- CN107569237A CN107569237A CN201710844101.0A CN201710844101A CN107569237A CN 107569237 A CN107569237 A CN 107569237A CN 201710844101 A CN201710844101 A CN 201710844101A CN 107569237 A CN107569237 A CN 107569237A
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- 102000001554 Hemoglobins Human genes 0.000 title claims abstract description 26
- 108010054147 Hemoglobins Proteins 0.000 title claims abstract description 26
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- 238000001228 spectrum Methods 0.000 claims abstract description 22
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Abstract
The invention discloses a kind of Non-invasive detection hemoglobin device.The present invention proposes the content of the hemoglobin in the method detection blood based on dynamic spectrum.The problem of overcoming the cyanmethemoglobin detection method having pointed out and real-time test method (POCT) two methods be invasive and the shortcomings that infection risk be present, while overcoming above two method to monitor in real time using noninvasive compound Dynamic spectrum；The precision for the non-invasive monitoring method having pointed out is improved by using light emitting diode and the corresponding operating circuit of improvement simultaneously, overcomes its problem of signal attenuation caused by circulating sampling.So as to which the present invention proposes, a kind of precision is high, and stability is good, and cost is low, and small volume is easy to monitor in real time, can obtain the noninvasive hemoglobin detection device of photoelectric sphyg ripple and dynamic spectrum simultaneously.
Description
Technical field
The invention belongs to non-invasive medical diagnostics field, is related to a kind of method using dynamic spectrum and carries out detection hemoglobin
Horizontal measuring method and device.
Background technology
Human body hemoglobin concentration is diagnosis anemia (Hb is relatively low) and true property Hyperhemoglobinemia (Hb is higher)
One of reliable basis.On the other hand, the concentration level of hemoglobin also reflects the presence of some diseases, such as heart and lung diseases, kidney
Dirty disease, tumor disease, chronic plateau sickness etc..Decreased hemoglobin is with increasing the phase for all reflecting measured in health status
It should change, detection hemoglobin concentration can be used for analyzing the health condition of measured.Therefore the side of hemoglobin concentration is detected
Method has increasingly caused the concern of people.The method currently existed has two kinds：Cyanmethemoglobin detection method and immediately
Method of inspection (POCT).There is the deficiency of many for the two methods having pointed out.Such as, it has been suggested that two methods need to tested
Person carries out taking blood to sample, and is invasive detection method, and such method has the risk of infection.
Another deficiency of the above method is, it has been suggested that two methods exist between blood collection and analysis process
Delay, it is difficult to monitored in real time to patient with severe symptoms.
Simultaneously it has been proposed that a kind of non-invasive detection methods, the method that this method utilizes composite light source spectrum, will be collected
Signal pass through amplifying circuit successively again by analog switch after opto-electronic conversion, signal is sent into AD after bandwidth-limited circuit
It is last in conversion equipment to reach host computer by embedded system.Carried out successively using the light of different fixed wave length through sample pool
Detection.
Method set forth above can not also reach the required accuracy well, and its reason is that AD multichannel collectings needs are each
Channel cycle gathers, so for some passage, during this conversion, signal is decay.If AD conversion
Quickly, fast 10 times or higher of change of the speed of conversion than signal in itself, then attenuation amplitude is smaller, and high-speed AD cost compared with
It is high.If AD speed is not high, it is necessary to which sampling is kept.In the AD multichannel circulating sampling times, sampling is kept inevitably
Generation voltage declines, and the speed and the quality of circuit capacitance that voltage declines have relation, so as to generation system error.After sampling is kept
Voltage sample value reduces, and the reason for causing signal errors is exactly the poll time of AD multichannel collectings.
So propose that a kind of precision meets clinical criteria, and instrument miniaturization, it is easy to what is monitored in real time, cost is low, surely
Qualitative good hemoglobin non-invasive detector has very important significance.
The content of the invention
The invention aims to improve and enrich non-invasive medical diagnostics field, overcome the cyaniding high ferro having pointed out blood red
Protein assay and real-time test method (POCT) two methods are invasive and the shortcomings that infection risk be present, while overcome above two
The problem of method can not monitor in real time；The precision for the non-invasive monitoring method having pointed out is improved, overcomes it caused by circulating sampling
Signal errors problem and propose that a kind of precision is high, stability is good, and cost is low, and small volume is easy to the noninvasive blood monitored in real time
Lactoferrin detection means.The present invention is detected using Dynamic spectrum.
When light beam incident medium, output intensity is relevant with incident intensity, concentration of medium and equivalent optical path length.Therefore,
The key detected using spectroscopic methodology is accurate absorption spectrum of the extraction based on hemoglobin absorption effect.Accurately to be moved
The absorption spectrum of arteries and veins blood, it is proposed that the concept of dynamic spectrum.It can show that primary-Bill of youth of amendment is fixed by theory deduction
Rule, can obtain the conclusion that the absorbance component of absorption and the scattering of non-arterial blood and each layer tissue has all been eliminated, therefore
The difference of absorbance when artery is full and during arterial contraction is only by other absorptions such as hemoglobin in arterial blood and arterial blood
Partial contribution, mainly reflect the Change of absorption of arterial blood.Hemoglobin has good absorption to the light of specific wavelength,
So it can be weighed well using the dynamic spectrum extracted corresponding to each Single wavelength in single photoelectric sphyg wave period blood red
The concentration level of albumen.The detection of the dynamic spectrum of the present invention based on photoplethysmography by being detected.
The photoplethysmographic under different monochromatic light actions is extracted, therefrom extracts dynamic spectrum information.Due to the detection of dynamic spectrum
It is to be carried out for just penetrating the instantaneous value of light intensity, (about 1 second) spectrum must be repeatedly swept within a pulse cycle time
Retouch, there is the characteristics of time resolution, but the method for existing spectral detection generally use long-time integration detects to improve at present
Precision, the measurement of pulse wave is not appropriate for, therefore the present invention proposes that a kind of AC compounent that can extract dynamic spectrum (characterizes
Arterial portions amplitude) spectral method of detection lift the diagnostic accuracy to pulse wave, this common spectrum for being also and having pointed out
One of main distinction of detection method.
The detection of dynamic spectrum typically has two kinds of light splitting schemes, i.e. time domain optical spectroscopy and spatial domain optical spectroscopy.Time domain optical spectroscopy
Referring to, by light-splitting device, tested tissue is incided in timesharing to the light that wideband light source is sent one by one before by sample cell, in order that
Hemoglobin noninvasive detection device minimizes, and portability is of the present invention to be replaced using the light emitting diode that specific wavelength occur
It is divided for traditional AOTF, overcomes the shortcomings that space needed for AOTF light splitting is big, and cost is higher.
What the present invention was realized in：The present invention be by photoelectric conversion module, Signal-regulated kinase, signal acquisition module,
What communication module and host computer formed.
Wherein photoelectric conversion module is made up of light source generator and source collectors.In order to increase accuracy of detection, the present invention
Eight fingers are detected simultaneously, the corresponding photoelectric conversion device of each finger, each photoelectric conversion device correspond to
The coloured light of different wave length, so as to obtain the same time of eight fingers different wave length photoelectric sphyg ripple and dynamic spectrum.For
Hemoglobin noninvasive detection device is allowed to minimize, portability, light source of the invention uses the light emitting diode of specific wavelength.Together
When, the AOTF crystal output optical signal that the emergent light of light emitting diode is relatively conventional is stronger, and this is also more embodied from luminous
The superiority of diode.Source collectors select photodiode, and I/V change-over circuits can reach the voltage output of certain amplitude.
There are respective signal conditioning circuit, signal acquisition module after per opto-electronic conversion all the way.The method that the present invention uses dynamic spectrum,
The loss of signal is reduced, improves measuring accuracy.
Signal-regulated kinase is passed through according to different ripples by amplifying circuit, the gain of bandwidth-limited circuit, wherein amplifying circuit
The power of long signal is adjusted correspondingly, and does not require the strict conformance of gain, reduces the requirement to circuit, while can increase
To the accuracy of detection of low energy wavelength signals.For bandwidth-limited circuit, the present invention rejects pulse using the method for wavelet transformation
Unusual ripple in ripple, reduce the pulse wave caused by factor such as the change by environmental factor, the activity of the consciousness of people, position chanP
Rapid distortion, greatly improve the accuracy of detection.
Signal acquisition module uses 16 AD, gathers photoelectric sphyg ripple DC component and AC compounent two paths of signals, this hair
It is bright that a/d converter, and the general module by a/d conversion device with corresponding CPU as each passage are controlled using corresponding CPU
To reach the purpose for making to reach matching and coordination between each passage of whole system.
Communication module includes slave computer and host computer.The Photoelectric Pulse Wave Signal collected can be uploaded to by slave computer
Position machine.Host computer can either carry out communicating with slave computer obtains photoelectric sphyg ripple, and and can carries out letter to multichannel photoelectric sphyg ripple
Number processing, which obtains, dynamic optical spectrogram and to be shown.The communication modes of wherein host computer and slave computer it is wired with wireless two kinds, wherein
Wired mode can utilize CAN, I2C, serial ports, parallel port, wireless mode can utilize WI-FI, bluetooth, infrared, microwave etc.
Other forms.
Host computer, mainly receive data, processing and show.
Brief description of the drawings
Fig. 1 is the detecting system schematic diagram that Non-invasive detection hemoglobin device of the present invention uses light emitting diode.
Fig. 2 is Non-invasive detection hemoglobin apparatus system schematic diagram of the present invention.
Fig. 3 is Non-invasive detection hemoglobin device CPU control flow charts of the present invention.
In figure：A, light source generator, using light emitting diode B, source collectors, turned using photodiode C, photoelectricity
Change module D, Signal-regulated kinase E, signal acquisition module.
Embodiment
The present invention will be further described below in conjunction with the accompanying drawings.
Fig. 1 provides the detecting system schematic diagram that Non-invasive detection hemoglobin device of the present invention uses light emitting diode.
Wherein A is light source generator, and the present invention is using light emitting diode.The light emitting diode that the present invention uses has
Can launch the feature of the coloured light of fixed wave length, corresponding eight fingers of eight light emitting diodes launch 660 respectively, 730,735,
760th, 805,810, the 850, coloured light of 940nm fixed wave length.Because eight fingers detect simultaneously, i.e., the coloured light of eight different wave lengths
Trigger simultaneously, the problem of measurement accuracy caused by overcoming the method for having pointed out caused signal weakening due to poll is relatively low.Fig. 1
In B be source collectors, its role is to receive to pass through the coloured light of sample, then convert optical signal into after electric signal is easy to
Continuous processing.The source collectors of the present invention use photodiode, with the illumination of the coloured light irradiated suffered by photodiode
The change of intensity, the electric current of photodiode also change therewith, the conversion through I/V conversion circuits, can be by the electric current of change
Signal is converted into the output of voltage.The purpose for converting optical signal into the electric signal for being easy to processing is thus reached.
Fig. 2 gives Non-invasive detection hemoglobin apparatus system schematic diagram of the present invention.D is Signal-regulated kinase, per all the way
By amplifying circuit, bandwidth-limited circuit is formed, totally eight tunnels, i.e., each finger is corresponding all the way.Obtained due to photoelectric conversion module
Electrical signal intensity is smaller, so the present invention uses amplifying circuit, the ultra-weak electronic signal collected is amplified, is easy to subsequently locate
Reason.Because the present invention synchronizes measurement to eight fingers, per corresponding the coloured light of different wavelength all the way, it is possible to root
Different amplifying circuit gains is set according to different wavelength coloured light, so as to without requiring the strict conformance of every road gain amplifier, reach
The purpose reduced to circuit requirement is arrived, while this design can be very good purposefully to increase and low energy signal is put
Big effect, effectively improves the degree of accuracy of measurement.Due to the change of external environment, the variation of the position figure of people and people's
The activity of ideology can impact to measurement result, so in order to eliminate such influence, the present invention proposes bandpass filtering
The method that circuit is filtered out to the signal not in the frequency range of measurement target, the method is to pass through wavelet analysis realization
's.Wavelet decomposition is carried out to obtained signal, can decompose to obtain the signal in the range of different frequency, then filter out non-targeted institute
The signal of the frequency needed, eliminates influence of the different factors to measurement result, enhances the confidence level of measurement result.E is signal
Acquisition module, 16 AD have data acquisition, the function that bus uploads on piece.16 AD driving light emitting diodes start work on piece
Make, and examine the signal that collects whether be needed for fixed wave length coloured light signal, worked on if needed for obtaining, if
Light emitting diode is then closed to undesired signal, and feeds back to control CPU and carries out alert operation flow as shown in Figure 3.Meanwhile this
The itd is proposed host computer of invention has the function of recording photoelectricity pulse wave and dynamic spectrum simultaneously.It can be examined what is obtained
Disconnected result combines with dynamical spectral property carries out disease forecasting by neutral net, and base is laid for follow-up functions expanding
Plinth, while also extend the function to other diseases diagnosis.
Claims (4)
1. a kind of method using compound dynamic spectrum detect the measuring method and device of hemoglobin level, its feature exists
In：The different wave length coloured light that is sent by light emitting diode while finger tip or ear-lobe position are irradiated to, are then received by photosensitive tube.Energy
Enough systematic errors effectively removed caused by sampling is kept.
2. a kind of method using compound dynamic spectrum as claimed in claim 1 detect the measurement side of hemoglobin level
Method and device is characterized in that：Light source is used as by the use of the light emitting diode for the coloured light that can launch fixed wave length.
3. a kind of method using compound dynamic spectrum as claimed in claim 1 detect the measurement side of hemoglobin level
Method and device is characterized in that：Signal noise caused by a variety of change of external conditions is removed using the method for wavelet analysis.
4. a kind of method using compound dynamic spectrum as claimed in claim 1 detect the measurement side of hemoglobin level
Method and device is characterized in that：It is acquired and communicates using single single-chip microcomputer per photosignal all the way.
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| CN106073716A (en) * | 2016-06-28 | 2016-11-09 | 丹阳慧创医疗设备有限公司 | A kind of multicenter near-infrared spectrum cerebral function formation method of intelligence frequency-division modulation |
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|---|---|---|---|---|
| US6397093B1 (en) * | 1996-12-05 | 2002-05-28 | Essential Medical Devices, Inc. | Non-invasive carboxyhemoglobin analyzer |
| WO2012032536A2 (en) * | 2010-09-06 | 2012-03-15 | Abhishek Sen | System and method for non-invasive determination of hemoglobin concentration in blood |
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