CN111803085A - Noninvasive hemoglobin concentration level measuring device based on color characteristics - Google Patents
Noninvasive hemoglobin concentration level measuring device based on color characteristics Download PDFInfo
- Publication number
- CN111803085A CN111803085A CN202010785166.4A CN202010785166A CN111803085A CN 111803085 A CN111803085 A CN 111803085A CN 202010785166 A CN202010785166 A CN 202010785166A CN 111803085 A CN111803085 A CN 111803085A
- Authority
- CN
- China
- Prior art keywords
- color
- concentration level
- hemoglobin concentration
- level measuring
- measuring apparatus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
- A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Artificial Intelligence (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Computation (AREA)
- Fuzzy Systems (AREA)
- Mathematical Physics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Physiology (AREA)
- Psychiatry (AREA)
- Signal Processing (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a non-invasive hemoglobin Hb (Haemoglobin) concentration level measuring device based on color characteristics, belongs to the fields of novel digital medical detection and monitoring instruments, spectral measurement, colorimetric measurement, photometric measurement and the like, and particularly relates to non-invasive measurement of the hemoglobin concentration level of a human body. The invention relates to a non-invasive hemoglobin concentration level measuring device based on color characteristics, which can quickly obtain information related to the hemoglobin concentration level of a human body in real time by measuring the colors of the finger tip, palm, limb, face, eyelid and other parts of the human body. The device can be used for designing and manufacturing a completely noninvasive hemoglobin monitoring or detecting instrument, and has the advantages of real-time rapidness, convenience, no material consumption, no adverse side effect and the like. The measuring device mainly comprises a light source assembly, a color sensor assembly, a data processing and calculating unit and the like.
Description
Technical Field
The invention belongs to the fields of novel digital medical detection instruments, photoelectric detection instruments, spectral measurement, colorimetric measurement and the like, and particularly relates to a non-invasive human hemoglobin Hb (Haemoglobin) level detection or monitoring technology.
Background
The detection or monitoring of the concentration level of human hemoglobin is one of the routine examination items of clinical diagnosis and treatment, and has higher clinical value in the aspects of anemia diagnosis, disease evaluation, treatment guidance and curative effect observation. At present, the hemoglobin concentration is clinically measured mainly by adopting an invasive laboratory detection method, the measurement result is accurate and reliable, the method is the standard of clinical hemoglobin concentration detection, but pain exists, and the analysis period is long and real-time monitoring is difficult to carry out. In recent years, with the vigorous development of spectral analysis technology, the noninvasive hemoglobin monitoring instrument is gradually applied to clinic and public at home and abroad, which is beneficial to improving medical detection and monitoring, and general investigation and prevention and treatment of anemia diseases, and has important research value and social significance.
Anemia is a clinical syndrome with a lower than normal volume of red blood cells in the systemic circulating blood, has complex pathogenic causes, and is an important clinical manifestation of hematopoietic organ diseases and even certain severe diseases. According to survey reports of the world health organization, the number of people affected by anemia diseases is up to 16 hundred million worldwide, and the number of people dying from various diseases caused by anemia is up to ten million every year. Anemia diseases become a public health problem with high global morbidity and long-term existence. The conditions facing the pregnant and newborn populations are particularly acute in anemic patients. Because of the dual requirements of the pregnant woman and the fetus on hematogenous substances during pregnancy, the pregnant woman is very easy to suffer from anemia, and related documents show that the incidence rate of pregnancy combined anemia of the pregnant woman in China is as high as 30%. The neonatal anemia is caused by insufficient acquisition of hematogenic substances during pregnancy and belongs to the chain reaction of maternal anemia. At present, about 30-40% of newborn infants suffer from anemia, seriously affect the digestive system, the immune function, the development of organs and bones of the whole body of the infant, and are easy to have the phenomena of anorexia, monophagia, low immunity, even mental retardation and the like.
In recent years, in the international, many research and development institutions or companies have been developing novel noninvasive hemoglobin level detection or monitoring technologies, including NIRO (hamamax corporation), Astrim (SYSMEX corporation, japan), radial-7 (Masimo corporation, usa), Pronto-7 (Masimo corporation, usa), and the like, which can basically realize noninvasive continuous detection or monitoring of human hemoglobin, but the detection accuracy and reliability of the technologies and products have a large space for improvement.
Relevant researches show that under the irradiation of visible light and near infrared light, the color presented by human blood is related to the concentration level of hemoglobin Hb (Haemoglobin) in the human blood, so that non-invasive color measurement can be performed by using the reflection and transmission characteristics of certain parts of a human body to a spectrum, and further the analysis and calculation of the hemoglobin concentration level are realized.
The invention provides a non-invasive hemoglobin concentration level measuring device based on color characteristics, which adopts light beams with certain spectral energy distribution to irradiate specific parts of a human body, such as fingers, palms, wrists, heads and faces, and then measures and analyzes standard colorimetric parameters or custom-space colorimetric parameters of transmitted or reflected light after the action of blood tissues of the human body, thereby realizing the real-time detection or monitoring of the hemoglobin concentration level of the human body. The invention can realize a non-invasive human hemoglobin level detection or monitoring device, and has the advantages of real time, rapidness, convenience, no material consumption, no side effect and the like.
In the past, many literatures at home and abroad have published some apparatuses, methods, systems and the like for measuring the level of hemoglobin without wound based on the optical principle.
Chinese patent CN208031214U, "a measuring device for non-invasive detection of hemoglobin level", which adopts multiple narrow-band light sources, and performs spectrum transmission detection on eight fingers simultaneously to obtain photoelectric pulse waves and dynamic spectra of the eight fingers at different wavelengths at the same time, and performs hemoglobin level analysis. Chinese patent CN103584870A, "non-invasive hemoglobin meter and its detection method", which uses near infrared light source to irradiate the superficial artery network of eyelid conjunctiva, collect reflected light to perform blood vessel appearance analysis and red shade analysis, and convert the analysis result into quantity and compare with the standard value to obtain the hemoglobin value. Chinese patent CN201810481778.7, the present invention discloses a near infrared non-invasive detection method for hemoglobin concentration index of human tissue, which adopts three spectral channels. Chinese patent CN201710844101.0, "a method and an apparatus for non-invasively measuring hemoglobin level", proposes a method for measuring hemoglobin content in blood based on dynamic spectroscopy.
Foreign invention patent aspect: us patent 10709366, "multi-stream data acquisition system for non-invasive detection of blood constituents," which employs a set of photodiodes, a plurality of photodetectors arranged in a particular geometry, to form a non-invasive device capable of generating an optical signal responsive to attenuation of tissue at a measurement site. Us patent 10548520, "non-invasive optical measurement of blood analytes," whose light source is wavelength tunable, and whose detector can continuously detect frequencies of the full spectrum, and likewise can be tuned to detect near infrared wavelengths or other spectra that are capable of penetrating tissue. Us patent 10568514, "enhanced visible near infrared photodiode and non-invasive physiological sensor", uses InGaAs photodiodes in combination with Si photodiodes to measure a wider range of wavelengths to detect visible and near infrared wavelength optical radiation after attenuation by tissue. Us patent 6615064, "non-invasive blood component analyzer", which simultaneously measures the absorbance of one or more specific wavelengths of visible or infrared light through a patient's finger, toe, or earlobe, and from these measurements and analysis of different absorbances and different optical path lengths, the concentration of a specific blood component can be derived.
The invention patents at home and abroad have the common characteristic that near-infrared band light is adopted to act on a human body, the transmission spectrums or the reflection spectrums of a plurality of spectrum channels are measured, and then the measurement results of the spectrums are analyzed, so that the concentration level of the hemoglobin is obtained. None of them are hemoglobin concentration measurement devices or systems based on "color characteristics".
Disclosure of Invention
The invention provides a measuring device for non-invasive hemoglobin concentration level detection and monitoring based on color characteristics. The device adopts light beams with certain spectral energy distribution to irradiate specific parts of a human body, such as fingers, palms, wrists, faces and the like, and then measures and analyzes standard chromaticity parameters (such as CIE1931 XYZ) or custom space chromaticity parameters of transmitted light or reflected light after the action of blood tissues of the human body, thereby realizing the real-time detection or monitoring of the concentration level of hemoglobin of the human body. The invention can realize the non-invasive human hemoglobin level detection or monitoring device, and has the advantages of real time, rapidness, convenience, no material consumption, no side effect and the like.
The invention is mainly characterized in that: the method adopts a multi-spectral-band illumination and measurement device comprising a visible light spectrum and a near infrared spectrum to realize the measurement and analysis of standard chromaticity parameters or custom space chromaticity parameters of specific parts of a human body, and then calculates hemoglobin concentration parameters according to the chromaticity parameters, thereby realizing the real-time detection or monitoring of the hemoglobin level.
The technical solution to implement the present invention is as follows.
A non-invasive hemoglobin concentration level measuring apparatus based on color characteristics; the device mainly comprises a light source component, a color sensor component, a data processing and calculating unit and the like, and the working principle is as follows: the light beam with fixed spectral power distribution emitted by the light source component irradiates relevant parts of a human body, such as fingers, palms, wrists, faces and the like; the light beam irradiates the relevant part of the human body and then has transmission and reflection conditions; taking a transmitted light beam as an example, the light beam contains color information related to the concentration of hemoglobin in a human body and is converted into digital color information by the color sensor assembly; the digital color information is then converted by the data processing and computing unit into information relating to the hemoglobin concentration level.
One of the characteristics of the invention is as follows: converting a light signal reflected or transmitted by a human body into a chrominance signal of a standard color space, e.g., tristimulus XYZ, chromaticity coordinates (x, y) or (L, a) of CIE1931XYZ standard space using a color sensor assembly*,b*) (ii) a Or converted to chromaticity coordinates of a custom color space.
The invention has another characteristic that: and establishing a calculation model of the human body color information and the hemoglobin concentration level by analyzing the actual human body online measurement data. The calculation model uses tristimulus value space XYZ or chromaticity space (x, y), (L, a)*,b*) Mapping to the hemoglobin concentration level space. The specific algorithm model comprises: chroma-concentration look-up tables, linear or non-linear conversion formulas, artificial neural network mapping models, and the like.
The light source component can adopt a halogen lamp, a white light LED and the like with wide spectral energy distribution. The light sources described above may also be combined with color filters to produce light sources having various spectral distribution characteristics. According to design requirements, the emitting light source can also adopt a series of LEDs, lasers and the like with fixed wavelength and bandwidth, and the LEDs, the lasers and the like are matched with the color sensor to obtain better color measurement effect.
The color sensor assembly can adopt a three-primary color sensor with the spectral tristimulus response consistent with or approximate to that of a CIEXYZ standard observer so as to directly generate a standard chrominance signal; other sensor arrays with narrow-band or broadband spectral transmission characteristics can also be used and a standardized measurement of color is achieved by spectral reconstruction.
The data processing and calculating unit comprises a chrominance parameter calculating model, a chrominance-concentration mapping model and the like; the implementation method of the 'chromaticity-concentration mapping model' comprises a 'chromaticity-concentration lookup table', 'linear or nonlinear conversion formula', 'artificial neural network mapping algorithm' and the like; they may be implemented by specific computer hardware and software.
Drawings
FIG. 1 is a schematic diagram of the principle of the composition of a non-invasive hemoglobin concentration level measuring apparatus based on color characteristics of the present invention, wherein a is a reflection device and b is a transmission device;
FIG. 2 is a schematic structural diagram of a first embodiment of a non-invasive hemoglobin concentration level measuring apparatus based on color characteristics of the present invention;
FIG. 3 is a schematic structural diagram of a second embodiment of a non-invasive hemoglobin concentration level measuring apparatus based on color characteristics according to the present invention;
reference numbers in fig. 1: 1 is light source component, 2 is measured human body position, 3 is color sensor component, 4 is data processing and calculating unit.
Detailed Description
The invention is described in detail below by way of example with reference to the accompanying drawings.
The invention provides a noninvasive hemoglobin concentration level measuring device based on color characteristics, which comprises a light source component 1, a measured human body part 2, a color sensor component 3 and a data processing and calculating unit 4, as shown in figure 1.
The working process of the noninvasive hemoglobin concentration level measuring device based on the color characteristics provided by the invention is as follows: the light beam with fixed spectral power distribution emitted by the light source component 1 is irradiated on a tested human body 2 after being collimated by the light beam, and reacts with blood tissues of the human body to generate a transmission light beam and a reflection light beam; the transmitted or reflected light beams will be received by the color sensor assembly 3 and generate the CIE standard tri-stimulus signal X, Y, Z representative of the color characteristics of the blood; the tri-stimulus signal X, Y, Z is then processed and calculated by the data processing and calculation unit 4 to obtain the hemoglobin concentration level information, which may be expressed in g/dL or kg/L.
Example 1: a non-invasive hemoglobin concentration level measuring apparatus based on color characteristics using a transmitted light beam is shown in fig. 2.
The light source component adopts a halogen lamp or LED lamp light source with continuous emission power in the range from visible light to near infrared spectrum; the light source irradiates the fingertip part of a human body after being collimated and generates a transmission beam; the transmitted beam is then received by the color sensor assembly; the color sensor assembly consists of two beam splitting prisms plus three separate X, Y, Z sensors, where the spectral sensitivity response of the X, Y, Z sensor is the same as the standard observer spectral sensitivity of the CIE1931XYZ system, so that the tristimulus XYZ signal of the CIEXYZ standard can be obtained in real time. The tristimulus XYZ signals are processed by a data processing and computing unit: first, the standard chromaticity coordinates (x, y) or (L, a) corresponding to the XYZ signal are calculated*,b*) And then determining the concentration level information of the hemoglobin by a chroma-concentration lookup table.
The light source assembly comprises a halogen lamp or an LED light source with small power (for example, less than 5 watts) so as to avoid excessive power consumption; it has a continuous spectral power distribution in both the visible and near infrared bands.
The X, Y, Z sensors all use a combination of filters with certain area and silicon (Si) detectors to receive larger beam energy; their spectral sensitivity responses are identical to the standard observer spectral sensitivity of the CIE1931XYZ system, respectively.
The data processing and calculating unit has a standard chromaticity coordinate calculating function and a function of calculating the concentration of hemoglobin by chromaticity coordinates. This embodiment will establish a set of chromaticity coordinates (x, y) or (L, a) according to a large amount of human body measurement experimental data*,b*) To a look-up table of hemoglobin concentrations. The above-described data processing and computing functions may be performed by a computer program.
Example 2: a non-invasive hemoglobin concentration level measuring apparatus based on color characteristics using a reflected light beam is shown in fig. 3.
The light source component adopts a halogen lamp with continuous emission power in the range from visible light to near infrared spectrum, and adopts a group of (total 3) XYZ filters capable of being switched rapidly; the spectral transmittance curve of the XYZ filter is the same as or similar to the spectral sensitivity curve of a standard observer of a CIE1931XYZ system; the light source is collimated and then irradiates the surface of the palm of the human body, and a reflected light beam is generated; the reflected beam is then received by a unitary photosensor whose spectral sensitivity response curve is as flat as possible in the visible spectrum, which, in combination with a light source, produces the CIEXYZ standard tristimulus XYZ signal. The tristimulus XYZ signals are processed by a data processing and computing unit: first, the standard chromaticity coordinates (x, y) or (L, a) corresponding to the XYZ signal are calculated*,b*) And then a group of artificial neural networks (BP-ANN) are used for mapping to obtain the concentration level information of the hemoglobin.
The light source assembly comprises a halogen lamp or an LED light source with small power (for example, less than 5 watts) so as to avoid excessive power consumption; it has a continuous spectral power distribution in both the visible and near infrared bands.
The photoelectric sensor adopts a combination of an optical filter with a certain area and a silicon (Si) detector to obtain a flat spectral sensitivity response curve; the spectral sensitivity response obtained by combining the photoelectric sensor and the light source is respectively the same as the spectral sensitivity of a standard observer of a CIE1931XYZ system.
The data processing and calculating unit has a standard chromaticity coordinate calculating function and a function of calculating the concentration of hemoglobin by chromaticity coordinates. This embodiment will establish a set of chromaticity coordinates (x, y) or (L, a) according to a large amount of human body measurement experimental data*,b*) An artificial neural network mapped to hemoglobin concentration; the artificial neural network is a feedforward type multilayer perception network and is trained by adopting a BP algorithm. Both the data processing and the artificial neural network functions described above may be performed by a computer program.
The two embodiments listed above are only preferred embodiments of the present invention, and are not intended to limit the scope of the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A non-invasive hemoglobin concentration level measurement apparatus based on color characteristics, characterized by: the whole device mainly comprises a light source component, a color sensor component, a data processing and calculating unit and the like.
2. The color characteristic-based noninvasive hemoglobin concentration level measuring apparatus of claim 1, wherein: the light source component adopts a halogen lamp with wide spectrum energy distribution, a white light LED and the like.
3. The color characteristic-based noninvasive hemoglobin concentration level measuring apparatus of claim 1, wherein: the light source component can also adopt a combination of a halogen lamp or other wide-band lamps and an XYZ color filter; the XYZ filter can be switched in real time to produce a spectral power emission characteristic that is consistent with or approximates the spectral tristimulus response function of a standard observer of the CIEXYZ system.
4. The color characteristic-based noninvasive hemoglobin concentration level measuring apparatus of claim 1, wherein: the light source module may also employ other color separation means in combination with a halogen lamp or other wide-band lamp, such as grating color separations, prism color separations, liquid crystal tuning device color separations, acousto-optic tuning device color separations, and the like.
5. The color characteristic-based noninvasive hemoglobin concentration level measuring apparatus of claim 1, wherein: the color sensor assembly is formed by combining XYZ three-channel sensors, the spectral sensitivities of the three-channel sensors are respectively consistent with or approximate to the spectral tristimulus response function of a standard observer of the CIEXYZ system, and a standard chrominance signal can be directly generated.
6. The color characteristic-based noninvasive hemoglobin concentration level measuring apparatus of claim 1, wherein: the color sensor assembly may also employ a unitary photosensor that cooperates with the light source assembly to form a spectral sensitivity that is consistent with or approximates the spectral tristimulus response function of a standard observer of the CIEXYZ system to produce a standard colorimetric signal.
7. The color characteristic-based noninvasive hemoglobin concentration level measuring apparatus of claim 1, wherein: the color sensor assembly may also employ a multi-element linear or area array photoelectric sensor that cooperates with the light source assembly to form a spectral sensitivity that is consistent with or similar to the spectral tristimulus response function of a standard observer of the CIEXYZ system to produce a standard chrominance signal.
8. The color characteristic-based noninvasive hemoglobin concentration level measuring apparatus of claim 1, wherein: the color sensor assembly may also employ other dispersive devices in combination with the array sensor, such as grating separations, prism separations, liquid crystal tuning device separations, acousto-optic tuning device separations, interferometric separations, and the like.
9. The color characteristic-based noninvasive hemoglobin concentration level measuring apparatus of claim 1, wherein: the data processing and calculating unit comprises a chromaticity parameter calculating model, a chromaticity-hemoglobin concentration mapping model and the like; wherein the "chromaticity parameter calculation model" can calculate CIE standard chromaticity parameters such as (x, y), (L, a) from CIE standard tristimulus values XYZ*,b*) Etc.; the 'chroma-hemoglobin concentration mapping model' comprises a 'chroma-concentration lookup table', 'linear or nonlinear conversion formula', 'artificial neural network mapping algorithm' and the like; these models can be implemented by specific computer hardware and software.
10. The color characteristic-based noninvasive hemoglobin concentration level measuring apparatus of claim 1, wherein: the part of the human body to be detected can be the finger tip, or other parts such as palm, wrist, earlobe, head face, eyelid and the like.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010785166.4A CN111803085A (en) | 2020-08-06 | 2020-08-06 | Noninvasive hemoglobin concentration level measuring device based on color characteristics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010785166.4A CN111803085A (en) | 2020-08-06 | 2020-08-06 | Noninvasive hemoglobin concentration level measuring device based on color characteristics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111803085A true CN111803085A (en) | 2020-10-23 |
Family
ID=72863102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010785166.4A Pending CN111803085A (en) | 2020-08-06 | 2020-08-06 | Noninvasive hemoglobin concentration level measuring device based on color characteristics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111803085A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288136A (en) * | 2021-07-06 | 2021-08-24 | 山东大学齐鲁医院 | Non-invasive detection device and detection method for hemoglobin concentration index of human tissue |
| CN113616189A (en) * | 2021-07-15 | 2021-11-09 | 武汉大学 | Method, device, equipment and storage medium for detecting amount of blepharoconjunctival hemoglobin |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1673743A (en) * | 2005-03-30 | 2005-09-28 | 中国科学院长春光学精密机械与物理研究所 | Chromatic evaluating method for medical biochemical analysis |
| CN103070658A (en) * | 2011-09-15 | 2013-05-01 | 富士胶片株式会社 | Endoscope system and light source device |
| CN103732116A (en) * | 2011-09-05 | 2014-04-16 | 富士胶片株式会社 | Endoscope system, processor device and image display method |
| CN104616301A (en) * | 2015-02-04 | 2015-05-13 | 上海未来伙伴机器人有限公司 | Intelligent robot color sensor based chrominance analysis method, device and system |
| CN104884937A (en) * | 2012-12-26 | 2015-09-02 | 日本电气株式会社 | Image measuring method, system, device, and program |
| CN106725263A (en) * | 2016-12-15 | 2017-05-31 | 深圳开立生物医疗科技股份有限公司 | It is applied to the imaging method of endoscopic system |
| US20180120162A1 (en) * | 2016-03-04 | 2018-05-03 | WENZHOUJIAYI INSTRUMENTS Co. Ltd. | Method for performing color measurement using standard light source color matching observation box |
| CN108024689A (en) * | 2015-09-24 | 2018-05-11 | 奥林巴斯株式会社 | Endoscope apparatus |
-
2020
- 2020-08-06 CN CN202010785166.4A patent/CN111803085A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1673743A (en) * | 2005-03-30 | 2005-09-28 | 中国科学院长春光学精密机械与物理研究所 | Chromatic evaluating method for medical biochemical analysis |
| CN103732116A (en) * | 2011-09-05 | 2014-04-16 | 富士胶片株式会社 | Endoscope system, processor device and image display method |
| CN103070658A (en) * | 2011-09-15 | 2013-05-01 | 富士胶片株式会社 | Endoscope system and light source device |
| CN104884937A (en) * | 2012-12-26 | 2015-09-02 | 日本电气株式会社 | Image measuring method, system, device, and program |
| CN104616301A (en) * | 2015-02-04 | 2015-05-13 | 上海未来伙伴机器人有限公司 | Intelligent robot color sensor based chrominance analysis method, device and system |
| CN108024689A (en) * | 2015-09-24 | 2018-05-11 | 奥林巴斯株式会社 | Endoscope apparatus |
| US20180120162A1 (en) * | 2016-03-04 | 2018-05-03 | WENZHOUJIAYI INSTRUMENTS Co. Ltd. | Method for performing color measurement using standard light source color matching observation box |
| CN106725263A (en) * | 2016-12-15 | 2017-05-31 | 深圳开立生物医疗科技股份有限公司 | It is applied to the imaging method of endoscopic system |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288136A (en) * | 2021-07-06 | 2021-08-24 | 山东大学齐鲁医院 | Non-invasive detection device and detection method for hemoglobin concentration index of human tissue |
| CN113288136B (en) * | 2021-07-06 | 2022-10-04 | 山东大学齐鲁医院 | Noninvasive detection device and detection method for hemoglobin concentration index of human tissue |
| CN113616189A (en) * | 2021-07-15 | 2021-11-09 | 武汉大学 | Method, device, equipment and storage medium for detecting amount of blepharoconjunctival hemoglobin |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Fantini et al. | Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry | |
| JP3649732B2 (en) | Non-invasive non-spectrophotometric infrared measurement of blood analyte concentration | |
| CA2494030C (en) | Method for spectrophotometric blood oxygenation monitoring | |
| JP5982364B2 (en) | Apparatus and method for identifying and monitoring components or characteristics of a measurement medium, in particular physiological blood values | |
| EP0650591B1 (en) | Non-invasive testing | |
| US7558619B2 (en) | Raman instrument for measuring weak signals in the presence of strong background fluorescence | |
| Martinez et al. | Optimal wavelength selection for noncontact reflection photoplethysmography | |
| Reddy et al. | A novel calibration-free method of measurement of oxygen saturation in arterial blood | |
| CN101933809B (en) | Multiband reflection spectrum noninvasive blood component measuring device and method | |
| JPH09503585A (en) | Non-spectrophotometric measurement of analyte concentration and optical properties of objects | |
| JP2004290544A (en) | Blood analyzer | |
| CN109154564A (en) | non-invasive blood analysis | |
| Pinto et al. | Non-invasive hemoglobin measurement using embedded platform | |
| CN111803085A (en) | Noninvasive hemoglobin concentration level measuring device based on color characteristics | |
| CN105942984B (en) | Jaundice detection method and its device | |
| US20210000391A1 (en) | A method of selecting the intensity of a light source for monitoring an analyte in blood, and a device thereof | |
| US8126527B2 (en) | Method and system for determining the contribution of hemoglobin and myoglobin to in vivo optical spectra | |
| Timm et al. | Non-invasive optical real-time measurement of total hemoglobin content | |
| Chugh et al. | Low cost calibration free Pulse oximeter | |
| CN111671436A (en) | Temperature-compensated photoacoustic noninvasive hemoglobin detection device and detection method | |
| WO2004010138A1 (en) | Measurement of an analyte concentration in a scattering medium | |
| CN108593593A (en) | Serial double infrared spectrum Woundless blood sugar measuring devices | |
| Pinto et al. | Improving hemoglobin estimation accuracy through standardizing of light-emitting diode power | |
| Damianou | The wavelength dependence of the photoplethysmogram and its implication to pulse oximetry | |
| Patil et al. | Methods and devices to determine hemoglobin non invasively: A review |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20201023 |
|
| WD01 | Invention patent application deemed withdrawn after publication |