CN107568731A - A kind of Co-Q10 fish oil nanoemulsions and preparation method and application - Google Patents
A kind of Co-Q10 fish oil nanoemulsions and preparation method and application Download PDFInfo
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Abstract
The present invention relates to a kind of Co-Q10 fish oil nanoemulsions and preparation method and application.The present invention uses nanoscale science and technology, oil-in-water type nanoscale milk particle is made in fish oil and Co-Q10, fish oil and cozymase Q 10 nano milk particle can be directly by oral cavities, the mucous membranes such as nasal cavity, small intestine directly absorb, so as to increase substantially absorption of the human body to fish oil and Co-Q10, then effect becomes apparent the elderly especially to have been failed to metabolic function.
Description
Technical field
The present invention relates to a kind of Co-Q10 fish oil nanoemulsions and preparation method and application, belong to food technology of preparing
Field.
Background technology
Fish oil contains omega-fatty acid needed by human --- EPA and DHA.EPA --- unimpeded blood vessel：Help to maintain blood
Manage unimpeded, pre- preventing thrombosis generation, the generation of prevention apoplexy or miocardial infarction；The fat accumulated in blood is removed, prevention of arterial is hard
The generation for changing and preventing peripheral vessel to block.DHA --- brain tonic and intelligence development：It is that brain cell forms, develops and operate indispensable
Material base, can promote, coordinate the conduction of neural circuit, to maintain the normal operation of brain cell.It is overstrain one's nerves
Student and working clan suitably supplement DHA can strengthen memory, focus on improve understandability, and the elderly supplement
DHA then contributes to active thinking, prevents senile dementia.Improve mood：It is a large amount of clinical experiments have proved that people's phase with not liking to eat fish
Than, love eat fish person face the difficulty showed with pressure to obtain it is more positive optimistic because the EPA contained in fish and DHA also changes
The effect of kind mood.
Supplement Co-Q10 contributes to：(1) cardioprotection：Coenzyme q-10 helps to provide sufficient oxygen, pre- protrusion-dispelling for cardiac muscle
Hair property heart disease, Co-Q10 plays key effect especially during myocardial anoxia.(2) promote energy conversion, lift energy：
It is energy (such as ATP) necessary to cells survival that coenzyme q-10, which is helped food conversion, cell is kept optimum state, makes one to feel
Energy is more abundant；(3) immunity, anti-aging are improved：Coenzyme q-10 is the caused natural of cell itself, can be prevented
The formation of free radical, help to safeguard the normal operation of immune system and anti-aging.
In existing food technology, the listing formulation that fish oil or Co-Q10 are commonly used is entirely soft capsule.Due to fish oil
Contain six unsaturated double-bonds in DHA molecular structure, therefore to oxygen, light and heat are all extremely sensitive, and oxygen easily occurs
Change, DHA oxidations are exactly to cause content to reduce first, its effect is affected, and secondly, oxidation product is harmful to health, take in body
It is interior to cause lipid peroxidation, induce various physically different so as to triggering disease.And Co-Q10 is a kind of fat-soluble anti-oxidant
Agent.See that light easily decomposes.In order to control DHA oxidation, its stability is improved, it is conveniently applied to normal food and health care food
In product, the measure taken at present mainly uses antioxidant.
The content of the invention
It is an object of the invention to overcome the shortcomings of Co-Q10 fish oil soft capsule formulation on the market, there is provided a kind of
Water oil-packaging type micro-emulsion drink and preparation method thereof, it can provide human body two kinds of beneficial complement agent simultaneously.Its emulsifier compared with
Small, simple using food grade emulsifier, edible safety, preparation method, milk particle is uniformly dispersed, and particle diameter reaches nanoscale, stability
Preferably, good absorbing.Water oil-packaging type micro-emulsion can preferably cover the distinctive smell of fish oil, and protect fish oil and coenzyme well
Q10 influences from undesirable element in environment, and so as to produce harmful oxidation product, less milk particle can improve biology
Availability.Then effect becomes apparent the elderly especially to have been failed to metabolic function.
According to technical solution of the present invention, using nanoscale science and technology, oil-in-water type nanoscale is made in fish oil and Co-Q10
Milk particle, fish oil and cozymase Q 10 nano milk particle directly can directly be absorbed by the mucous membrane such as oral cavity, nasal cavity, small intestine, so as to increase substantially
Absorption of the human body to fish oil and Co-Q10, then effect becomes apparent the elderly especially to have been failed to metabolic function.
Technical solution of the present invention is as follows.
A kind of Co-Q10 fish oil nanoemulsions, its pH are 6.0-8.0, contain following components with bulking value densimeter：
Co-Q10 0.02%-25%,
Fish oil 0%-20%,
Emulsifying agent 0.5%-5%,
Vegetable oil 0-20%,
Flavouring 0-10%,
Antioxidant 0-0.5%,
Preservative 0-0.5%,
Appropriate pH adjusting agent,
Purified Water q. s；
Wherein, it is that oil-in-water type nanoscale milk particle is made in fish oil and Co-Q10.
Further, the particle diameter (average grain diameter) of the oil-in-water type nanoscale milk particle is less than or equal to 600nm, is preferably
200-400nm。
Further, the Zeta potential of the Co-Q10 fish oil nanoemulsions is -20mV to -40mV.
Further, the content of the Co-Q10 is 0.02%-12%, preferably 0.02%-6%.
Further, the content of the fish oil is 0.5%-15%, preferably 0.5%-10%.
Further, the content of the emulsifying agent is 1.0%-3.0%, preferably 1.5%.
Further, the pH adjusting agent includes sodium hydroxide.2% sodium hydrate aqueous solution can be used.
Further, the fish oil includes the one or more in tuna, salmon, sturgeon, sardine, trout etc..
In addition to Co-Q10 and fish oil, remaining each component can carry out dosage adjustment according to being actually needed.
The emulsifying agent include soybean lecithin, phosphatide, sapn (SPAN), tween (TWEEN) class, succinylated monoglyceride,
One or more in sucrose fatty ester etc..
Further, the flavouring includes the one or more in glucose, fructose, ammonium glycyrrhetate, steviol glycoside etc..
Further, the vegetable oil includes the one or more in linseed oil, soybean oil, corn oil, algae oil etc..
Further, the antioxidant includes the one or more in ascorbyl palmitate, vitamin E etc..
Further, the preservative includes ethyl-para-hydroxybenzoate, sodium benzoate, potassium sorbate etc..
Preferably embodiment of the invention is that a kind of Co-Q10 fish oil nanoemulsions, its pH is 6.0-8.0, with weighing body
Product densimeter contains following components：
Co-Q10 0.4%,
Fish oil 10%,
Phosphatide or soybean lecithin 1.5%,
Ammonium glycyrrhetate 0.01%,
Vitamin E 0.02%,
Potassium sorbate 0.05%,
Appropriate pH adjusting agent,
Purify water surplus；
Wherein, it is that oil-in-water type nanoscale milk particle is made in fish oil and Co-Q10, the oil-in-water type nanoscale milk particle
Particle diameter (average grain diameter) is 200-400nm.
The present invention also provides the preparation method of above-mentioned Co-Q10 fish oil nanoemulsions, comprises the following steps：
1) aqueous phase is prepared：Emulsifying agent is added in alkaline purified water, or further can also add water-soluble component for example
Flavouring, preservative etc.；Under nitrogen protection, shearing is to being uniformly dispersed；
2) oil phase is prepared：By fish oil and Co-Q10, it is well mixed；Or it further can also add water insoluble component example
Such as vegetable oil, antioxidant, it is well mixed；
3) oil phase is added in aqueous phase, colostrum, regulation system pH value to 6.0-8.0 is made in shearing；
4) high-pressure homogeneous, obtained nanoemulsions are carried out to colostrum using gradient boost mode.
Further, the pH value of step 1) the alkaline purified water is 8-12,2% sodium hydrate aqueous solution can be used to carry out
Regulation.
Further, step 1) controls water temperature as 45~55 DEG C during preparing aqueous phase.
Further, step 2) prepares 45-55 DEG C of control system temperature during oil phase.
Further, the step 4) gradient boost is：First carry out 200-400bar low pressure recycle processing, then 500-
The processing of 700bar cycle of higher pressure；The temperature control of the homogenization is at 40~60 DEG C.
Low pressure recycle processing is first carried out, the purpose is to which the larger particle of particle diameter is crushed, prevents from damaging under high pressure
High pressure homogenizer；Then cycle of higher pressure processing increases the stability of milk particle again.
Present invention also offers application of the Co-Q10 fish oil nanoemulsions in food, field of health care products.According to real
Border demand, it can be made into formulation conventional in food and field of health care products, such as oral liquid.
Present invention mainly solves the problem of be that a nanometer micro emulsion is made in Co-Q10 fish oil, using food grade emulsifier, pass through
Appropriate emulsifier, suitable pH value, solves fish oil and Co-Q10 is oxidizable, and milk particle stablizes the problem of poor.It is more beneficial for
The elderly that raising metabolic function has failed is to fish oil and Co-Q10 degree of absorbing.
The present invention has found without using mixed surfactant by experimental study, uses a small amount of single edible surface
Activating agent soybean lecithin or phosphatide etc. make emulsifying agent, the preferred 1.0-3.0% of dosage of emulsifying agent.By controlling ph value of emulsion model
Enclose, optimal ph scope is 6.0-8.0, is pelletized using two-step method, and the oil-in-water type Co-Q10 fish oil that can be made stable is oral
Emulsion.
Fish oil and Co-Q10 solution not soluble in water, it is to be dispersed in Co-Q10 particle of fish oil by a small amount of emulsifying agent
A kind of oil in water dispersion system formed in water.By improving solution ph, two-step method granulation, increase charge particles lotus amount
Add, add the stability of preparation, avoid fish oil and Co-Q10 is oxidized problem.
Advantages of the present invention：
Using nanoscale science and technology, nanoscale milk particle is made in Co-Q10 fish oil, Co-Q10 fish oil nanometer milk particle can be straight
Connect and directly absorbed by mucous membranes such as oral cavity, nasal cavity, small intestines, so as to increase substantially absorption of the human body to Co-Q10 fish oil, especially
Then effect becomes apparent the elderly to have been failed to metabolic function.
It is an object of the invention to for Co-Q10 fish oil soft capsule formulation on the market, there is provided a kind of brand-new
The preparation method of the water oil-packaging type micro-emulsion drink of Co-Q10 fish oil.It can provide human body two kinds of beneficial complement agent simultaneously.Its breast
Agent dosage is smaller, simple using food grade emulsifier, edible safety, preparation method, and particle is uniformly dispersed, and particle diameter reaches nanometer
Level, stability are preferable so that micro emulsion can preferably cover the distinctive smell of fish oil, and protect fish oil and coenzyme well
Q10 influences from undesirable element in environment, and so as to produce harmful oxidation product, less particle can improve biology
Availability.It can arbitrarily be dissolved each other with milk, beverage etc. simultaneously, facilitate old people garment to use.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.It is unreceipted specific in embodiment
Technology or condition person, carried out according to the technology or condition described by document in the art, or according to product description.It is used
Reagent or the unreceipted production firm person of instrument, it is the conventional products that can be commercially available by regular distributor.
Zeta current potentials are also known as surface potential, be microparticle surfaces electrically charged quantity sign, the stability with microparticle system
It is relevant, zeta current potentials can be it is just or negative, with auxiliary material it is relevant, the fat fat breast surface as made from making emulsifying agent with phosphatide is electric
Position is negative.General Zeta potential absolute value is higher, and its interparticle electrostatic repulsion is also bigger, and physical stability is also better.
Zeta potential as described below is detected using this area conventional method.
Embodiment 1
A kind of Co-Q10 fish oil nanoemulsions, its pH are 6.8, and its Zeta potential is -23.75mV, with bulking value concentration
Meter contains following components：
Co-Q10 0.4%,
Fish oil 10%,
Phosphatidase 1 .5%,
Ammonium glycyrrhetate 0.01%,
Vitamin E 0.02%,
Potassium sorbate 0.05%,
Appropriate pH adjusting agent,
Purify water surplus；
Wherein, it is that oil-in-water type nanoscale milk particle, its average grain diameter 387nm is made in fish oil and Co-Q10.
Embodiment 2
A kind of preparation method of Co-Q10 fish oil nanoemulsions, its composition of raw materials is same as Example 1, including following step
Suddenly：
1) aqueous phase is prepared：The purified water of recipe quantity is taken, it is 8-12 to adjust purified water pH value with 2% sodium hydroxide solution, will
Emulsifying agent is added to the water, and adds water-soluble component flavouring, potassium sorbate, under nitrogen protection, extremely divides in 45~55 DEG C of shearings
Dissipate uniform；
2) oil phase is prepared：Fish oil, Co-Q10 and other water insoluble component vegetable oil, antioxidant are mixed；Heating is stirred
Mix, control at 45~55 DEG C, mix；
3) oil phase is added in aqueous phase, colostrum, regulation system pH value to 6.8 is made in shearing；
4) high-pressure homogeneous, obtained nanoemulsions are carried out to colostrum using gradient boost mode；The gradient boost is specially：
200-400bar low pressure recycle processing is first carried out, the purpose is to which the larger particle of particle diameter is crushed, prevents from damaging under high pressure
Bad high pressure homogenizer；Then 500-700bar cycle of higher pressure is handled again, and the purpose is to increase the stability of milk particle.At the homogeneous
The temperature control of reason is at 40~60 DEG C.
Embodiment 3
A kind of Co-Q10 fish oil nanoemulsions, it is differed only in embodiment 1：Its pH is 7.6, its Zeta potential
For -26.97mV, the average grain diameter 321nm of oil-in-water type nanoscale milk particle is made up of fish oil and Co-Q10.
The preparation method of the Co-Q10 fish oil nanoemulsions is same as Example 2, differs only in：Step 3) adjusts body
It is pH value to 7.6；And appropriate set-up procedure 4) high-pressure homogeneous condition.
Embodiment 4
A kind of Co-Q10 fish oil nanoemulsions, it is differed only in embodiment 1：Its emulsifying agent is 1.5% soybean phosphorus
Fat, its pH are 7.2, and its Zeta potential is -22.83mV, and being averaged for oil-in-water type nanoscale milk particle is made by fish oil and Co-Q10
Particle diameter 359nm.
The preparation method of the Co-Q10 fish oil nanoemulsions is same as Example 2, differs only in：Step 3) adjusts body
It is pH value to 7.2；And appropriate set-up procedure 4) high-pressure homogeneous condition.
Embodiment 5
A kind of Co-Q10 fish oil nanoemulsions, it is differed only in embodiment 1：Its emulsifying agent is 1.5% soybean phosphorus
Fat, its pH are 7.9, and its Zeta potential is -27.18mV, and being averaged for oil-in-water type nanoscale milk particle is made by fish oil and Co-Q10
Particle diameter 302nm.
The preparation method of the Co-Q10 fish oil nanoemulsions is same as Example 2, differs only in：Step 3) adjusts body
It is pH value to 7.9；And appropriate set-up procedure 4) high-pressure homogeneous condition.
Comparative example 1
A kind of Co-Q10 fish oil nanoemulsions, it is differed only in embodiment 1：Its pH is 5.5, its Zeta potential
For -17.25mV, the average grain diameter 528nm of oil-in-water type nanoscale milk particle is made up of fish oil and Co-Q10.
The preparation method of the Co-Q10 fish oil nanoemulsions is same as Example 2, differs only in：Step 3) adjusts body
It is pH value to 5.5；And appropriate set-up procedure 4) high-pressure homogeneous condition.
Comparative example 2
A kind of Co-Q10 fish oil nanoemulsions, it is differed only in embodiment 4：Its pH is 4.8, its Zeta potential
For -16.12mV, the average grain diameter 515nm of oil-in-water type nanoscale milk particle is made up of fish oil and Co-Q10.
The preparation method of the Co-Q10 fish oil nanoemulsions is same as Example 2, differs only in：Step 3) adjusts body
It is pH value to 4.8；And appropriate set-up procedure 4) high-pressure homogeneous condition.
Experimental example
Conventional Co-Q10 fish oil formulation is soft capsule, and formulation of the invention is nanoemulsions；Micro emulsion of the present invention can be fine
Protect fish oil, Co-Q10 to be influenceed from undesirable element in environment.Less particle can improve human bioavailability.Together
When can arbitrarily be dissolved each other with milk, beverage etc., facilitate old people garment to use.By preferred emulsifier dosage, control ph value of emulsion is being ground
In the range of studying carefully, pelletized using two-step method, highly stable product can be made.
Embodiment 1,3-5 and comparative example 1-2 Co-Q10 fish oil nanoemulsions are detected respectively, as a result see the table below 1.
The different pH value Co-Q10 fish oil milk particle footpaths of table 1 and Zeta potential
Stability test is carried out to embodiment 3,5 and comparative example 1-2 Co-Q10 fish oil nanoemulsions respectively, as a result seen below
Table 2.
Different pH value Co-Q10 fish oil breast Zeta (mV) the current potentials long-time stability of table 2 investigate result
It was found from upper table 2, the absolute value of embodiment pH7.6 Zata current potentials differs 0.85mV after 12 months with initial value,
The absolute value of embodiment pH7.9 Zata current potentials differs 0.59mV after 12 months with initial value；And comparative example pH5.5 Zata electricity
The absolute value of position differ 4.13mV with initial value after 12 months, the absolute values of comparative example pH4.8 Zata current potentials after 12 months and
Initial value differs 4.96mV.Therefore, pH value is higher, and Co-Q10 fish oil breast Zeta changes are smaller, illustrate that emulsion is more stable.This hair
It is stable that bright Co-Q10 fish oil breast, which investigates milk particle for long-term 12 months,.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
- A kind of 1. Co-Q10 fish oil nanoemulsions, it is characterised in that its pH is 6.0-8.0, with bulking value densimeter contain with Lower component：Co-Q10 0.02%-25%,Fish oil 0%-20%,Emulsifying agent 0.5%-5%,Vegetable oil 0-20%,Flavouring 0-10%,Antioxidant 0-0.5%,Preservative 0-0.5%,Appropriate pH adjusting agent,Purified Water q. s；Wherein, it is that oil-in-water type nanoscale milk particle is made in fish oil and Co-Q10.
- 2. Co-Q10 fish oil nanoemulsions according to claim 1, it is characterised in that the oil-in-water type nanoscale breast The particle diameter of grain is less than or equal to 600nm, preferably 200-400nm.
- 3. Co-Q10 fish oil nanoemulsions according to claim 1 or 2, it is characterised in that the Co-Q10 fish oil is received The Zeta potential of rice milk liquid is -20mV to -40mV.
- 4. the Co-Q10 fish oil nanoemulsions according to claim any one of 1-3, it is characterised in that the Co-Q10 Content is 0.02%-12%, preferably 0.02%-6%；And/orThe content of the fish oil is 0.5%-15%, preferably 0.5%-10%；And/orThe content of the emulsifying agent is 1.0%-3.0%, preferably 1.5%.
- 5. the Co-Q10 fish oil nanoemulsions according to claim any one of 1-4, it is characterised in that the pH adjusting agent Including sodium hydroxide；And/orThe fish oil includes the one or more in tuna, salmon, sturgeon, sardine, trout；And/orThe emulsifying agent includes one in soybean lecithin, phosphatide, sapn, Tweens, succinylated monoglyceride, sucrose fatty ester Kind is several；And/orThe flavouring includes the one or more in glucose, fructose, ammonium glycyrrhetate, steviol glycoside；And/orThe vegetable oil includes the one or more in linseed oil, soybean oil, corn oil, algae oil；And/orThe antioxidant includes the one or more in ascorbyl palmitate, vitamin E；And/orThe preservative includes the one or more in ethyl-para-hydroxybenzoate, sodium benzoate, potassium sorbate.
- 6. Co-Q10 fish oil nanoemulsions according to claim 1, it is characterised in that its pH is 6.0-8.0, with weight Volumetric concentration meter contains following components：Co-Q10 0.4%,Fish oil 10%,Phosphatide or soybean lecithin 1.5%,Ammonium glycyrrhetate 0.01%,Vitamin E 0.02%,Potassium sorbate 0.05%,Appropriate pH adjusting agent,Purify water surplus；Wherein, it is that oil-in-water type nanoscale milk particle, the particle diameter of the oil-in-water type nanoscale milk particle is made in fish oil and Co-Q10 For 200-400nm.
- 7. a kind of preparation method of Co-Q10 fish oil nanoemulsions, it is characterised in that comprise the following steps：1) aqueous phase is prepared：Emulsifying agent is added in alkaline purified water, or further can also add water-soluble component；Nitrogen is protected Under, shearing is to being uniformly dispersed；2) oil phase is prepared：By fish oil and Co-Q10, it is well mixed；Or water insoluble component further can be also added, mixing is equal It is even；3) oil phase is added in aqueous phase, colostrum, regulation system pH value to 6.0-8.0 is made in shearing；4) high-pressure homogeneous, obtained nanoemulsions are carried out to colostrum using gradient boost mode.
- 8. preparation method according to claim 7, it is characterised in thatThe pH value of step 1) the alkaline purified water is 8-12；And/orStep 1) controls water temperature as 45~55 DEG C during preparing aqueous phase；And/orStep 2) prepares 45-55 DEG C of control system temperature during oil phase；And/orStep 4) the gradient boost is：200-400bar low pressure recycle processing is first carried out, then at 500-700bar cycle of higher pressure Reason；The temperature control of the homogenization is at 40~60 DEG C；And/orDescribed Co-Q10 fish oil nanoemulsions are identical with any one of claim 1-6.
- 9. Co-Q10 fish oil nanoemulsions prepared by the methods described of claim 7 or 8.
- 10. application of any one of claim 1-6,9 the Co-Q10 fish oil nanoemulsions in food, field of health care products.
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| CN107568731B (en) | 2020-09-29 |
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Address after: 321016 No.398, Xianhua North Street, Wucheng District, Jinhua City, Zhejiang Province Patentee after: Li Hong Patentee after: Zhejiang Shangyao Jiuxu Pharmaceutical Co.,Ltd. Address before: 321016 No.398, Xianhua North Street, Wucheng District, Jinhua City, Zhejiang Province Patentee before: Li Hong Patentee before: ZHEJIANG JIUXU PHARMACEUTICAL Co.,Ltd. |