CN105768109A - Vitamin D and calcium-containing microemulsion as well as preparation method and application thereof - Google Patents
Vitamin D and calcium-containing microemulsion as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN105768109A CN105768109A CN201610105829.7A CN201610105829A CN105768109A CN 105768109 A CN105768109 A CN 105768109A CN 201610105829 A CN201610105829 A CN 201610105829A CN 105768109 A CN105768109 A CN 105768109A
- Authority
- CN
- China
- Prior art keywords
- calcium
- micro emulsion
- vitamin
- oil
- emulsifying agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 57
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title claims abstract description 46
- 229930003316 Vitamin D Natural products 0.000 title claims abstract description 44
- 235000019166 vitamin D Nutrition 0.000 title claims abstract description 44
- 239000011710 vitamin D Substances 0.000 title claims abstract description 44
- 150000003710 vitamin D derivatives Chemical class 0.000 title claims abstract description 44
- 229940046008 vitamin d Drugs 0.000 title claims abstract description 44
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 43
- 239000011575 calcium Substances 0.000 title claims abstract description 43
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000000593 microemulsion method Methods 0.000 title 1
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 23
- 239000002245 particle Substances 0.000 claims abstract description 16
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 11
- 239000008158 vegetable oil Substances 0.000 claims abstract description 11
- 229960005069 calcium Drugs 0.000 claims description 40
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 230000033228 biological regulation Effects 0.000 claims description 9
- 239000012071 phase Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000003963 antioxidant agent Substances 0.000 claims description 8
- 230000003078 antioxidant effect Effects 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- 235000019198 oils Nutrition 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 7
- 230000002335 preservative effect Effects 0.000 claims description 7
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 210000003022 colostrum Anatomy 0.000 claims description 6
- 235000021277 colostrum Nutrition 0.000 claims description 6
- 229940083466 soybean lecithin Drugs 0.000 claims description 6
- 239000008346 aqueous phase Substances 0.000 claims description 5
- 125000005456 glyceride group Chemical group 0.000 claims description 5
- 239000000654 additive Substances 0.000 claims description 4
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical group [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 4
- 239000001527 calcium lactate Substances 0.000 claims description 4
- 229960002401 calcium lactate Drugs 0.000 claims description 4
- 235000011086 calcium lactate Nutrition 0.000 claims description 4
- 230000003204 osmotic effect Effects 0.000 claims description 4
- 235000012424 soybean oil Nutrition 0.000 claims description 4
- 239000003549 soybean oil Substances 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- 210000000481 breast Anatomy 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 238000010008 shearing Methods 0.000 claims description 3
- 235000005687 corn oil Nutrition 0.000 claims description 2
- 239000002285 corn oil Substances 0.000 claims description 2
- 235000021388 linseed oil Nutrition 0.000 claims description 2
- 239000000944 linseed oil Substances 0.000 claims description 2
- 239000007908 nanoemulsion Substances 0.000 claims description 2
- 230000007613 environmental effect Effects 0.000 abstract description 3
- 230000003647 oxidation Effects 0.000 abstract description 3
- 238000007254 oxidation reaction Methods 0.000 abstract description 3
- 239000006185 dispersion Substances 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 235000006708 antioxidants Nutrition 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 5
- 241000206575 Chondrus crispus Species 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 3
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 235000010987 pectin Nutrition 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 239000011647 vitamin D3 Substances 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- 229960002675 xylitol Drugs 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000007102 metabolic function Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000005282 vitamin D3 Nutrition 0.000 description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
- 229940021056 vitamin d3 Drugs 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 1
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001749 antrachitic effect Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a vitamin D and calcium-containing microemulsion as well as a preparation method and an application thereof. The microemulsion comprises the following components in percentage by weight: 0.0005-0.5% of vitamin D, 1.0-10.0% of calcium source, 0.5-3% of emulsifier and 1.0-10.0% of vegetable oil. The microemulsion is less in emulsifier dosage, simple in preparation method, high in drug-loading rate, uniform in particle dispersion and good in stability and has the advantages that the particle size reaches nanometer scale; the vitamin D can be well protected from the influence of environmental factors and oxidation products harmful to the human health cannot be produced; and the bioavailability is increased at the same time.
Description
Technical field
The present invention relates to a kind of micro emulsion containing vitamin D calcium and its preparation method and application, belong to
Health care of food product preparation field.
Background technology
Calcium is the base stock of skeleton development, in addition to directly affecting height, also to safeguarding that body is good for
Health, it is ensured that normal growth is grown and had important function.As participated in nerve, the activity of muscle and god
Release through mediator；The secretion of regulation hormone.Regulation the rhythm of the heart, reduce cardiovascular permeability,
Control inflammation and the effect such as oedema, maintenance acid-base balance.
Vitamin D is steroid derivative, has anti-rachitic effect, raw also known as rickets dimension
Element.It is now recognized that vitamin D is also a kind of steroid hormone, in vitamin D family member
Important member is VD2 (ergocalciferol) and VD3 (Vitamin D3).Vitamine D3 is made
For one of necessary vitamin of human body, play vital effect, such as regulation calcium and Bone m etabolism.
But, it is usually present dimension at the emulsion containing vitamin D and calcium disclosed in prior art raw
D is oxidizable for element, the problem that emulsion is unstable.
In view of this, spy of the present invention proposes a kind of micro emulsion containing vitamin D calcium.
Summary of the invention
The present invention provides a kind of micro emulsion containing vitamin D calcium, and its emulsifier is less, preparation
Method is simple, and drugloading rate is relatively big, and particle is uniformly dispersed, and particle diameter reaches nanoscale, and stability is relatively
Good, it is possible to preferably protection vitamin D, from such environmental effects, produces harmful
Oxidation product, improves bioavilability simultaneously.
The technical solution adopted in the present invention is as follows:
A kind of micro emulsion containing vitamin D calcium, including the component of following weight portion: vitamin D
0.0005%-0.5%, calcium source 1.0%-10.0%, emulsifying agent 0.5%-3%, vegetable oil
1.0%-10.0%.
Preferably, the described micro emulsion containing vitamin D calcium, including the component of following weight portion: dimension
Raw element D0.001%-0.2%, calcium source 2.0%-8.0%, emulsifying agent 1.0%-1.2%, vegetable oil
2.0%-8.0%.
In the described micro emulsion containing vitamin D calcium, described calcium source is selected from calcium lactate or gluconic acid
Calcium.
In the described micro emulsion containing vitamin D calcium, described emulsifying agent is by soybean lecithin and citric acid
Fatty glyceride is blended with mass ratio 1～3:1 and obtains.
In micro emulsion containing vitamin D calcium of the present invention, also include antioxidant 0.01%-0.02%,
Preservative 0.01%-0.02%, and add additives according to demand, such as flavouring is (such as grape
Sugar, xylitol etc.), osmotic pressure regulator (such as glycerine), thickener is (such as carragheen, pectin
Deng), antioxidant (such as ascorbyl palmitate) and preservative are (such as P-hydroxybenzoic acid second
Ester).
In the described micro emulsion containing vitamin D calcium, described vegetable oil selected from soybean oil, corn oil,
One or more in linseed oil.
The described micro emulsion particle diameter containing vitamin D calcium is less than 800nm, preferably smaller than 300nm；pH
Value is between 6.5-8.2, and preferable ph is 7.5.
The present invention also provides for the preparation method of a kind of micro emulsion containing vitamin D calcium, including walking as follows
Rapid:
(1) taking the purified water of recipe quantity, regulation pH value is 9～12, addition calcium source, emulsifying agent,
Under nitrogen protection, shearing emulsifier is to being uniformly dispersed, and water temperature controls, at 50～60 DEG C, to obtain water
Phase；
(2) vitamin D is added in vegetable oil, be heated to 40～50 DEG C, obtain oil phase；
(3) adding in aqueous phase by oil phase, shear and make colostrum, regulation system pH value is extremely
6.5～8.2；
(4) carrying out high-pressure homogeneous by colostrum, homogenizing temperature controls, at 40～60 DEG C, to be prepared into
To the breast grain nanoemulsions less than 800nm.
In described micro emulsion preparation method, step (1) also can add suitable additives, example
As add flavouring (such as glucose, xylitol etc.), osmotic pressure regulator (such as glycerine) with
And thickener (such as carragheen, pectin etc.).
In described micro emulsion preparation method, step (2) also can add in vegetable oil antioxidant
(such as ascorbyl palmitate), preservative (such as ethyl-para-hydroxybenzoate).
The present invention also provides for the above-mentioned micro emulsion containing vitamin D calcium in food, field of health care products
Application.
Micro emulsion containing vitamin D calcium of the present invention uses food-grade compound emulsifying agent, really
The most appropriate fixed emulsifier, suitable pH value, solve vitamin D oxidizable, emulsion due to
The addition of calcium salt and the problem that causes emulsion stability difference.Emulsion after mixing due to aqueous phase and oil phase
PH value decline by a big margin, it is therefore desirable to water oil mix after improve solution ph further,
Make charge particles lotus amount increase, and then increase the stability of preparation.In other words, Zeta potential
Absolute value is the highest, and system is the most stable.PH value additionally, micro emulsion drug carrying amount of the present invention is relatively big,
Particle is uniformly dispersed, and particle diameter reaches nanoscale, and stability is preferable so that micro emulsion can be preferably
Protection vitamin D is from such environmental effects, and then produces harmful oxidation product.
And less particle can a certain degree of raising bioavilability.
On the basis of technical scheme of the present invention, micro emulsion can be made by those skilled in the art
Oral liquid formulation, increase substantially the human body absorption to vitamin D by oral, it is to avoid existing
Inconvenience that the formulations such as some drug administration by injection are brought and the potential safety hazard that medicine brings.Of the present invention
The especially suitable the elderly then metabolic function failed of micro emulsion and metabolic function
Grow the most perfect infant.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1 (embodiment of best results)
The present embodiment provides a kind of micro emulsion containing vitamin D calcium, by the component system of following weight portion
: vitamin D30.0013%, calcium lactate 5.7%, emulsifying agent 1.2%, soybean oil 5%；Its
Middle emulsifying agent is obtained so that mass ratio 1:1 is blended by soybean lecithin and citric acid fatty glyceride.
Gained micro emulsion pH value is 7.5.
Described in the present embodiment, the micro emulsion containing vitamin D calcium is to comprise the following steps:
(1) taking the purified water of recipe quantity, regulation pH value is 11, addition calcium lactate, emulsifying agent,
Under nitrogen protection, shearing emulsifier is to being uniformly dispersed, and water temperature controls, at 60 DEG C, to obtain aqueous phase；
(2) vitamin D is added in soybean oil, be heated to 50 DEG C, obtain oil phase；
(3) oil phase is added in aqueous phase, shear and make colostrum, regulation system pH value to 7.5；
(4) carrying out high-pressure homogeneous by colostrum, homogenizing temperature controls, at 50 DEG C, to prepare and receive
Rice emulsion.
Described step (2) also can add antioxidant (such as ascorbic acid palm in vegetable oil
Acid esters), preservative (such as ethyl-para-hydroxybenzoate).
Embodiment 2
The present embodiment provides a kind of micro emulsion containing vitamin D calcium, and it is with embodiment 1 difference,
Wherein emulsifying agent by soybean lecithin and citric acid fatty glyceride so that mass ratio 3:1 is blended
?.
Embodiment 3
The present embodiment provides a kind of micro emulsion containing vitamin D calcium, and it is with embodiment 1 difference,
Described microemulsion system is 6.5.
Embodiment 4
The present embodiment provides a kind of micro emulsion containing vitamin D calcium, and it is with embodiment 1 difference,
Described microemulsion system is 8.2.
Embodiment 5
The present embodiment provides a kind of micro emulsion containing vitamin D calcium, and it is with embodiment 1 difference,
Possibly together with antioxidant 0.01%, preservative 0.01%.And add additives according to demand, such as
Flavouring (such as glucose, xylitol etc.), osmotic pressure regulator (such as glycerine), thickener (as
Carragheen, pectin etc.), antioxidant (such as ascorbyl palmitate) and preservative are (as right
Nipagin A).
Comparative example 1
This comparative example provides a kind of micro emulsion containing vitamin D calcium, and it is with embodiment 1 difference,
Wherein emulsifying agent is soybean lecithin.
Comparative example 2
This comparative example provides a kind of micro emulsion containing vitamin D calcium, and it is with embodiment 1 difference,
Described microemulsion system is 5.5.
Compliance test result
Above-described embodiment and comparative example gained micro emulsion are detected, the results are shown in Table 1, table 2.
Table 1 particle diameter and Zeta potential
| Finished product pH value | Particle diameter (nm) | Zeta potential (mV) | |
| Embodiment 1 | 7.5 | 272 | -41.16 |
| Embodiment 2 | 7.5 | 286 | -39.52 |
| Embodiment 3 | 6.5 | 466 | -26.76 |
| Embodiment 4 | 8.2 | 351 | -33.35 |
| Comparative example 1 | 7.5 | 969 | -11.32 |
| Comparative example 2 | 5.5 | 632 | -19.91 |
As shown in Table 1, under the conditions of identical pH, the kind of emulsifying agent and proportioning are to micro emulsion
Particle diameter and current potential impact are more obvious, only select soybean lecithin as single breast such as comparative example 1
Agent, its gained micro emulsion particle diameter is only-11.32mV at 969nm, current potential.And select with greatly
Fabaceous Lecithin and citric acid fatty glyceride obtain as the embodiment 1,2 of compound emulsifying agent
Good finished product, size controlling at 300nm, current potential-39.52～-41.16, gained micro emulsion grain
Footpath is less, and beneficially bioavailability improves, and the highest Zeta potential can ensure micro emulsion
More stable.
Additionally, under formula same case, also the pH value of system is investigated, find to work as
When pH value is less than 6.5, such as comparative example 2, its micro emulsion not only particle diameter is relatively big, and current potential is less,
It is only-19.91mV.And the micro emulsion that pH value is between 6.5-8.2 not only particle diameter is little, Er Qie electricity
Position absolute value is high, is more beneficial for the raising of micro emulsion bioavailability and stablizing of vitamin D.
Although, the most with a general description of the specific embodiments the present invention is made
Detailed description, but on the basis of the present invention, it can be made some modifications or improvements, this
Will be apparent to those skilled in the art.Therefore, without departing from present invention spirit
On the basis of these modifications or improvements, belong to the scope of protection of present invention.
Claims (10)
1. the micro emulsion containing vitamin D calcium, it is characterised in that include following weight portion
Component: vitamin D 0.0005%-0.5%, calcium source 1.0%-10.0%, emulsifying agent 0.5%-3%,
Vegetable oil 1.0%-10.0%.
Micro emulsion the most according to claim 1, it is characterised in that include following weight portion
Component: vitamin D 0.001%-0.2%, calcium source 2.0%-8.0%, emulsifying agent 1.0%-1.2%,
Vegetable oil 2.0%-8.0%.
Micro emulsion the most according to claim 1 and 2, it is characterised in that described calcium source is selected from
Calcium lactate or calcium gluconae.
Micro emulsion the most according to claim 1 and 2, it is characterised in that described emulsifying agent
It is blended by soybean lecithin and citric acid fatty glyceride with mass ratio 1～3:1 and obtains.
5. according to the arbitrary described micro emulsion of claim 1-4, it is characterised in that described vegetable oil
One or more in soybean oil, corn oil, linseed oil.
6. according to the arbitrary described micro emulsion of claim 1-5, it is characterised in that described raw containing dimension
The micro emulsion particle diameter of element D calcium is less than 800nm, preferably smaller than 300nm.
7. according to the arbitrary described micro emulsion of claim 1-5, it is characterised in that described raw containing dimension
The micro emulsion pH value of element D calcium is between 6.5～8.2, and preferable ph is 7.5.
8. according to the arbitrary described micro emulsion of claim 1-5, it is characterised in that described micro emulsion is also
Including antioxidant 0.01%-0.02%, preservative 0.01%-0.02%, and add additional according to demand
Agent, the preferred flavouring of described additives, osmotic pressure regulator, thickener, antioxidant, anticorrosion
Agent.
9. the preparation method of micro emulsion containing vitamin D calcium, it is characterised in that include as
Lower step:
(1) taking the purified water of recipe quantity, regulation pH value is 9～12, addition calcium source, emulsifying agent,
Under nitrogen protection, shearing emulsifier is to being uniformly dispersed, and water temperature controls, at 50～60 DEG C, to obtain water
Phase；
(2) vitamin D is added in vegetable oil, be heated to 40～50 DEG C, obtain oil phase；
(3) adding in aqueous phase by oil phase, shear and make colostrum, regulation system pH value is extremely
6.5～8.2；
(4) carrying out high-pressure homogeneous by colostrum, homogenizing temperature controls, at 40～60 DEG C, to be prepared into
To the breast grain nanoemulsions less than 800nm.
10. the arbitrary described micro emulsion containing vitamin D calcium of claim 1-8 is at food, health products
Application in field.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610105829.7A CN105768109A (en) | 2016-02-25 | 2016-02-25 | Vitamin D and calcium-containing microemulsion as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610105829.7A CN105768109A (en) | 2016-02-25 | 2016-02-25 | Vitamin D and calcium-containing microemulsion as well as preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105768109A true CN105768109A (en) | 2016-07-20 |
Family
ID=56403060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610105829.7A Pending CN105768109A (en) | 2016-02-25 | 2016-02-25 | Vitamin D and calcium-containing microemulsion as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105768109A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108935657A (en) * | 2018-08-07 | 2018-12-07 | 江油市九顶科技有限公司 | A kind of organic vegetable bio-preservative, preparation method and mating preservation method |
| CN109452369A (en) * | 2018-07-17 | 2019-03-12 | 浙江九旭药业有限公司 | It is a kind of to receive cream and its preparation method and application containing milk powder |
| CN109588728A (en) * | 2017-09-30 | 2019-04-09 | 江苏正大丰海制药有限公司 | A kind of oral complete nutritional composition |
| CN109588697A (en) * | 2017-09-30 | 2019-04-09 | 江苏正大丰海制药有限公司 | A kind of oral complete nutritional composition |
| CN111481503A (en) * | 2020-04-09 | 2020-08-04 | 暨南大学 | Vitamin D3-loaded nano calcium carbonate pickering emulsion and preparation method and application thereof |
| CN112715952A (en) * | 2019-10-29 | 2021-04-30 | 湖北真奥医药研究院有限公司 | Multi-vitamin calcium self-emulsifying composition and preparation method of preparation thereof |
| CN116172895A (en) * | 2022-12-30 | 2023-05-30 | 株式会社资生堂 | Cosmetic composition |
| CN116406796A (en) * | 2023-04-06 | 2023-07-11 | 上海迦蓝海纳米技术集团有限公司 | Vitamin C emulsion with high bioavailability and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116925A (en) * | 1994-11-30 | 1996-02-21 | 王万梅 | Cod liver oil emulsion and its preparation |
| CN1562044A (en) * | 2004-04-12 | 2005-01-12 | 沈阳药科大学 | Witamin D2 calcium levulinate freeze-dried emulsion and its preparing method |
| CN101869302A (en) * | 2009-04-24 | 2010-10-27 | 牛欣 | Micro-emulsion calcium preparation and preparation method as well as application thereof |
-
2016
- 2016-02-25 CN CN201610105829.7A patent/CN105768109A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116925A (en) * | 1994-11-30 | 1996-02-21 | 王万梅 | Cod liver oil emulsion and its preparation |
| CN1562044A (en) * | 2004-04-12 | 2005-01-12 | 沈阳药科大学 | Witamin D2 calcium levulinate freeze-dried emulsion and its preparing method |
| CN101869302A (en) * | 2009-04-24 | 2010-10-27 | 牛欣 | Micro-emulsion calcium preparation and preparation method as well as application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 候秀英等: "《新编现代实用药剂学》", 31 July 2015, 西安交通大学出版社 * |
| 孟胜男等: "《药剂学》", 31 January 2016, 中国医药科技出版社 * |
| 赵应征等: "《生物药物制剂学》", 30 June 2011, 浙江大学出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109588728A (en) * | 2017-09-30 | 2019-04-09 | 江苏正大丰海制药有限公司 | A kind of oral complete nutritional composition |
| CN109588697A (en) * | 2017-09-30 | 2019-04-09 | 江苏正大丰海制药有限公司 | A kind of oral complete nutritional composition |
| CN109452369A (en) * | 2018-07-17 | 2019-03-12 | 浙江九旭药业有限公司 | It is a kind of to receive cream and its preparation method and application containing milk powder |
| CN108935657A (en) * | 2018-08-07 | 2018-12-07 | 江油市九顶科技有限公司 | A kind of organic vegetable bio-preservative, preparation method and mating preservation method |
| CN112715952A (en) * | 2019-10-29 | 2021-04-30 | 湖北真奥医药研究院有限公司 | Multi-vitamin calcium self-emulsifying composition and preparation method of preparation thereof |
| CN111481503A (en) * | 2020-04-09 | 2020-08-04 | 暨南大学 | Vitamin D3-loaded nano calcium carbonate pickering emulsion and preparation method and application thereof |
| CN116172895A (en) * | 2022-12-30 | 2023-05-30 | 株式会社资生堂 | Cosmetic composition |
| CN116406796A (en) * | 2023-04-06 | 2023-07-11 | 上海迦蓝海纳米技术集团有限公司 | Vitamin C emulsion with high bioavailability and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105768109A (en) | Vitamin D and calcium-containing microemulsion as well as preparation method and application thereof | |
| US10568843B2 (en) | Method of preparing highly stable microcapsule powders or microparticles containing fat-soluble nutrient having increased double bonds | |
| AU2003235715B2 (en) | 25-Hydroxy vitamin D3 compositions | |
| EP1575378B1 (en) | Pulverulent phytosterol formulations | |
| RU2287981C2 (en) | Water-soluble water-free ubiquinone q10 concentrate, method for its preparing, capsule, remedy for skin care and remedy for dental care that contain it | |
| CN102525923B (en) | Preparation method of carotenoid emulsion and microcapsules | |
| CN105746730A (en) | Nano-emulsion containing vitamin D and linseed oil as well as preparation method and application of nano-emulsion | |
| CN101919453B (en) | Medium carbon chain fatty acid powder grease and preparation method thereof | |
| JP2020528746A (en) | Fat-soluble nutrient microcapsules and their manufacturing method | |
| AU2015257786B2 (en) | Formulation of fat-soluble vitamin | |
| JP5691072B2 (en) | Treatment of hyperglycemia with 25-hydroxyvitamin D3 | |
| JP2011512343A (en) | Combination of 25-hydroxy-vitamin D3 and vitamin D3 to improve bone mineral density and treat osteoporosis | |
| JP6964660B2 (en) | Antioxidant dispersion | |
| JP2020508695A (en) | Stable fat-soluble active ingredient composition, microcapsule and method for producing the same and application | |
| JP2011512342A (en) | Combination of vitamin D and 25-hydroxyvitamin D3 | |
| CN107660620A (en) | A kind of sheep base oil grease microcapsule powder and preparation method thereof | |
| JP2011511826A (en) | Treatment of hypertension with 25-hydroxyvitamin D3 | |
| CN112754000A (en) | Method for preparing nano emulsion by using soybean protein isolate-tea saponin composite emulsifier | |
| CN107568731B (en) | Coenzyme Q10 fish oil nano emulsion and preparation method and application thereof | |
| CN104719913B (en) | A kind of algae oil DHA nanosuspension and its preparation method and application | |
| CN109122921B (en) | Preparation method of functional powdered oil | |
| CN108113008A (en) | A kind of lotion for reducing fat digestion and its preparation method and application | |
| WO2018015346A1 (en) | Propyl gallate-containing vitamin preparations | |
| EP3473240B1 (en) | A primarily anhydrous composition, in particular for use as nutritional supplements | |
| WO2013031949A1 (en) | Soft capsule pharmaceutical preparation, composition for soft capsule pharmaceutical preparation, and method for producing soft capsule pharmaceutical preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160720 |
|
| RJ01 | Rejection of invention patent application after publication |