CN105746730A - Nano-emulsion containing vitamin D and linseed oil as well as preparation method and application of nano-emulsion - Google Patents
Nano-emulsion containing vitamin D and linseed oil as well as preparation method and application of nano-emulsion Download PDFInfo
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- CN105746730A CN105746730A CN201610096942.3A CN201610096942A CN105746730A CN 105746730 A CN105746730 A CN 105746730A CN 201610096942 A CN201610096942 A CN 201610096942A CN 105746730 A CN105746730 A CN 105746730A
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- 235000021388 linseed oil Nutrition 0.000 title claims abstract description 60
- 239000000944 linseed oil Substances 0.000 title claims abstract description 60
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title claims abstract description 57
- 229930003316 Vitamin D Natural products 0.000 title claims abstract description 55
- 239000007908 nanoemulsion Substances 0.000 title claims abstract description 55
- 239000011710 vitamin D Substances 0.000 title claims abstract description 55
- 235000019166 vitamin D Nutrition 0.000 title claims abstract description 55
- 150000003710 vitamin D derivatives Chemical class 0.000 title claims abstract description 55
- 229940046008 vitamin d Drugs 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 14
- 235000013305 food Nutrition 0.000 claims abstract description 11
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 10
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 10
- 239000003755 preservative agent Substances 0.000 claims abstract description 10
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- 239000002245 particle Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 230000008569 process Effects 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 7
- 235000019198 oils Nutrition 0.000 claims description 7
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 239000008346 aqueous phase Substances 0.000 claims description 6
- 210000003022 colostrum Anatomy 0.000 claims description 6
- 235000021277 colostrum Nutrition 0.000 claims description 6
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 6
- 239000012071 phase Substances 0.000 claims description 6
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 5
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 5
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 5
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 229940083466 soybean lecithin Drugs 0.000 claims description 5
- 239000008158 vegetable oil Substances 0.000 claims description 5
- 239000011782 vitamin Substances 0.000 claims description 5
- 210000000481 breast Anatomy 0.000 claims description 4
- 230000036541 health Effects 0.000 claims description 4
- 238000013019 agitation Methods 0.000 claims description 3
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims description 2
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 claims description 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 2
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 2
- 210000002969 egg yolk Anatomy 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims description 2
- 150000003904 phospholipids Chemical class 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 239000004250 tert-Butylhydroquinone Substances 0.000 claims description 2
- 235000019281 tert-butylhydroquinone Nutrition 0.000 claims description 2
- 235000010384 tocopherol Nutrition 0.000 claims description 2
- 239000011732 tocopherol Substances 0.000 claims description 2
- 229960001295 tocopherol Drugs 0.000 claims description 2
- 229930003799 tocopherol Natural products 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 2
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 238000004945 emulsification Methods 0.000 claims 1
- 239000000839 emulsion Substances 0.000 abstract description 3
- 239000002105 nanoparticle Substances 0.000 abstract description 2
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 4
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 3
- 235000004431 Linum usitatissimum Nutrition 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 241000206575 Chondrus crispus Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000208202 Linaceae Species 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000002285 corn oil Substances 0.000 description 2
- 235000005687 corn oil Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 230000007102 metabolic function Effects 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 229920001277 pectin Polymers 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 235000005282 vitamin D3 Nutrition 0.000 description 2
- 239000011647 vitamin D3 Substances 0.000 description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
- 229940021056 vitamin d3 Drugs 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- TVEXGJYMHHTVKP-UHFFFAOYSA-N 6-oxabicyclo[3.2.1]oct-3-en-7-one Chemical compound C1C2C(=O)OC1C=CC2 TVEXGJYMHHTVKP-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000006240 Linum usitatissimum Species 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 230000001749 antrachitic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000004426 flaxseed Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
- A23D9/04—Working-up
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Edible Oils And Fats (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a nano-emulsion prepared from vitamin D and linseed oil as well as a preparation method and application of the nano-emulsion. The nano-emulsion is prepared from the following raw materials by mass percent: 0.02-1% of the vitamin D, 1-10% of the linseed oil, 0.5-3% of an emulsifying agent, 0.005-0.5% of an antioxidant, 0.005-0.5% of a preservative and the balance of water. The vitamin D and the linseed oil are prepared into nanoparticles by the food grade emulsifying agent, a proper dosage of the emulsifying agent and an appropriate PH value are determined, and granulation is realized by a two-step method, so that the problems that the vitamin D and the linseed oil are easily oxidized, and emulsion particles are poor in stability can be effectively solved.
Description
Technical field
The present invention relates to a kind of nanoemulsions containing vitamin D linseed oil and preparation method thereof
With application, belong to health care of food product technical field.
Background technology
Linseed oil, also known as linseed oil or siritch, is the drying oil produced from linseed.
Linseed oil contains special nutritional labeling, especially contains alpha-linolenic acid and is up to more than 50%, tool
There are important physiological function and high nutritive value.
Vitamin D is steroid derivative, has anti-rachitic effect, raw also known as rickets dimension
Element.It is now recognized that vitamin D is also a kind of steroid hormone, in vitamin D family member
Important member is VD2 (ergocalciferol) and VD3 (Vitamin D3).
In the prior art, vitamine D3 is as a kind of liposoluble vitamin, and its solubility is low,
And processing and storage condition such as light, temperature and oxygen etc. all can cause its isomerization or oxidation,
Its chemical constitution and physiological function are adversely affected, also reduces the biology of active material simultaneously
Utilization rate.It addition, vitamine D3 solubility is low, adds in food system and often occur
A series of problem, adversely affects flavour of food products, product stability, product appearance,
Add vitamine D3 difficulty in food processing process, limit answering at field of food
With.
Summary of the invention
It is an object of the invention to provide a kind of nanoemulsions containing vitamin D linseed oil, pass through
Use food grade emulsifier that vitamin D and linseed oil are made nanoparticle, determine appropriate
Emulsifier, suitable pH value, use two-step method to pelletize, thus it is raw to efficiently solve dimension
Element D linseed oil is oxidizable, the problem of breast grain poor stability.
To achieve these goals, the present invention adopts the following technical scheme that
A kind of nanoemulsions containing vitamin D linseed oil, by the raw material of following mass percent
Prepare: vitamin D 0.02%-1%, linseed oil 1%-10%, emulsifying agent 0.5%-3%, anti-
Oxidant 0.005%-0.5%, preservative 0.005%-0.5%, surplus is water.
It is further preferred that the described nanoemulsions containing vitamin D linseed oil, by following matter
The raw material of amount percentage prepares: vitamin D 0.2-0.8%, linseed oil 2-6%, emulsifying agent
0.8-1.5%, antioxidant 0.01-0.2%, preservative 0.01-0.2%, surplus is water.
The more preferably described nanoemulsions containing vitamin D linseed oil, by following mass percent
Raw material prepare: vitamin D 0.2%-0.4%, linseed oil 5%, emulsifying agent 0.8%-1.2%,
Antioxidant 0.01%-0.02%, preservative 0.01%-0.02%, surplus is water.
Described emulsifying agent is selected from soybean lecithin or yolk phospholipid.
Described antioxidant is selected from ascorbyl palmitate, butylated hydroxy anisole, dibutyl hydroxyl
One or more in base toluene, propylgallate, tert-butylhydroquinone or tocopherol.
Described preservative is selected from ethyl-para-hydroxybenzoate, Sodium Benzoate or potassium sorbate
Plant or multiple.
In order to make nanoemulsions meet the demand of some special populations, also can in emulsion suitably
Add sweet flavouring (such as glucose, xylitol etc.), osmotic pressure regulator (such as glycerine) with
And thickener (such as carragheen, pectin etc.).
Additionally, in order to preferably promote that vitamin D dissolves, also can be at linseed oil in the application
Middle addition vegetable oil (such as corn oil, soybean oil etc.) is configured to miscella, to improve further
The dissolubility of vitamin D.Wherein, vegetable oil is 1-2:1 with the volume ratio of linseed oil.
The gained of the present invention nanoemulsions containing vitamin D linseed oil can be good at protection dimension
Raw element D, linseed oil affect from undesirable element in environment.Gained nanoemulsions particle diameter is less than
800nm, even less than 600nm, pH is 5.5-8.3, preferably 6-8.3, and Zeta potential is at-36.75V
～between-13.93.It has been investigated that, Zeta potential absolute value is the highest, and emulsion system is the most stable,
And less particle can improve bioavilability, there is good applicability simultaneously, permissible
Arbitrarily dissolve each other with milk, beverage etc., facilitate old man to take with child.
The present invention also provides for the preparation method of a kind of nanoemulsions containing vitamin D linseed oil,
Comprise the steps:
1) prepare aqueous phase: added by emulsifying agent in alkaline water, under nitrogen protection, shear to dividing
Dissipate uniformly；
2) oil phase is prepared: add in linseed oil by vitamin D, antioxidant, preservative,
Add thermal agitation, mixing；
3) oil phase is added in aqueous phase, shear and make colostrum, regulation system pH value to 5.5～8.3,
Preferably 6～8.3；
4) use gradient boost mode to carry out high-pressure homogeneous to colostrum, prepare nanoemulsions.
In the preparation method of nanoemulsions of the present invention, step 1) in, described water also may be used
Add suitable additives, the sweetest flavouring (such as glucose, xylitol etc.), osmotic pressure
Conditioning agent (such as glycerine) and thickener (such as carragheen, pectin etc.).Described shearing water temperature
Control at 50～60 DEG C.In this step, the pH value of described alkaline water is between 8-12.
In the preparation method of nanoemulsions of the present invention, step 2) in, described whipping temp
Control at 40～50 DEG C.Additionally, in order to preferably promote that vitamin D dissolves, also can be in flax
Seed oil adds vegetable oil (such as corn oil, soybean oil etc.) and is configured to miscella, with further
Improve the dissolubility of vitamin D.Wherein, vegetable oil is 1-2:1 with the volume ratio of linseed oil.
In the preparation method of nanoemulsions of the present invention, step 4) in, described gradient boost
Process particularly as follows: first carry out 200～400bar low pressure recycle, its objective is particle diameter bigger
Particle pulverize, prevent under high pressure damaging high pressure homogenizer；The most again 500～
700bar cycle of higher pressure processes, and its objective is to increase the stability of breast grain.Described homogeneous processes
Temperature control at 40～60 DEG C.
Present invention also offers described containing vitamin D linseed oil nanoemulsions food,
Application in field of health care products.According to actual demand, can be made in food and field of health care products
Conventional formulation, such as oral liquid etc..
Vitamin D and the most water insoluble solution of linseed oil, but the present invention is a small amount of single by adding
Linseed oil containing vitamin D is dispersed in water by one emulsifying agent, forms a kind of oil-in-water and divides
Prose style free from parallelism system；By control solution pH value between 6.0-8.3, use two-step method to pelletize, make particulate
Electrically charged amount increases, and prepares degree of stability higher vitamin D linseed oil nanoemulsions.Should
Method is simple to operate, and resulting dosage forms drugloading rate is relatively big, and bioavilability is high.
Gained vitamin D linseed oil nanoemulsions of the present invention provides human body two kinds useful simultaneously
Replenishers, can directly be absorbed by the mucous membrane such as oral cavity, nasal cavity, thus increase substantially human body pair
The absorption of vitamin D linseed oil, is primarily adapted for use in and needs vitamin D, DHA and EPA
Crowd, the elderly especially failed metabolic function and metabolic function are grown the completeest
Kind infant becomes apparent from.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
1 one kinds of vitamin D linseed oil nanoemulsions of embodiment
The present embodiment provides a kind of nanoemulsions containing vitamin D linseed oil, and its formula is
(being calculated in mass percent): vitamin D 0.4%, linseed oil 5%, soybean lecithin 1%,
Ascorbyl palmitate 0.02%, ethyl-para-hydroxybenzoate 0.02%, surplus is water.
The preparation method of 2 one kinds of vitamin D linseed oil nanoemulsions of embodiment
The present embodiment provides the nanoemulsions described in above-described embodiment 1 containing vitamin D linseed oil
Preparation method, comprise the steps:
1) aqueous phase is prepared: take the purified water of recipe quantity, pure with 2% sodium hydroxide solution regulation
Changing water ph value is 8～12, is added to the water by emulsifying agent, under nitrogen protection, in 50～60 DEG C
Shear to being uniformly dispersed；
2) oil phase is prepared: add in linseed oil by vitamin D, antioxidant, preservative,
Add thermal agitation, control at 40～50 DEG C, mixing；
3) oil phase is added in aqueous phase, shear and make colostrum, regulation system pH value to 6.7；
4) use gradient boost mode to carry out high-pressure homogeneous to colostrum, prepare nanoemulsions；
Described gradient boost is particularly as follows: first carry out 200～400bar low pressure recycle process, its mesh
Be that particle bigger for particle diameter is pulverized, prevent under high pressure damaging high pressure homogenizer；So
After again 500～700bar cycle of higher pressure process, its objective is to increase the stability of breast grain.Described
The temperature that homogeneous processes controls at 40～60 DEG C.
The preparation method of 3 one kinds of vitamin D linseed oil nanoemulsions of embodiment
The present embodiment uses method described in embodiment 2 to prepare the raw containing dimension of formula described in embodiment 1
The nanoemulsions of element D linseed oil, differs only in, step 3) system pH is 6.0.
4 one kinds of vitamin D linseed oil nanoemulsions of embodiment
The present embodiment uses method described in embodiment 2 to prepare the raw containing dimension of formula described in embodiment 1
The nanoemulsions of element D linseed oil, differs only in, step 3) system pH is 7.6.
The preparation method of 5 one kinds of vitamin D linseed oil nanoemulsions of embodiment
The present embodiment uses method described in embodiment 2 to prepare the raw containing dimension of formula described in embodiment 1
The nanoemulsions of element D linseed oil, differs only in, step 3) system pH is 5.5.
The preparation method of 6 one kinds of vitamin D linseed oil nanoemulsions of embodiment
The present embodiment uses method described in embodiment 2 to prepare the raw containing dimension of formula described in embodiment 1
The nanoemulsions of element D linseed oil, differs only in, step 3) system pH is 8.3.
Gained nanoemulsions particle diameter be 326nm, pH be 8.3, Zeta potential is at-29.33mV.
7 one kinds of vitamin D linseed oil nanoemulsions of embodiment
The present embodiment provide a kind of use prepared by method described in embodiment 2 containing vitamin D flax
The nanoemulsions of seed oil, difference is: fill a prescription as (being calculated in mass percent): vitamin D
0.2%, linseed oil 5%, soybean lecithin 0.5%, ascorbyl palmitate 0.02%, to hydroxyl
Yl benzoic acid ethyl ester 0.02%, surplus is water.Step 3) system pH is 6.9.
8 one kinds of vitamin D linseed oil nanoemulsions of embodiment
The present embodiment provide a kind of use prepared by method described in embodiment 2 containing vitamin D flax
The nanoemulsions of seed oil, difference is: fill a prescription as (being calculated in mass percent): vitamin D
0.2%, linseed oil 5%, soybean lecithin 3%, ascorbyl palmitate 0.02%, to hydroxyl
Yl benzoic acid ethyl ester 0.02%, surplus is water.Step 3) system pH is 7.1.
The various embodiments described above gained nanoemulsions Indexs measure result such as table 1.
Table 1
From above-described embodiment, use the nanoemulsions that scheme of the present invention prepares, electricity
Position absolute value is high, and correspondingly degree of stability is good, and drugloading rate is relatively big, because it has less grain
Footpath, can further improve its bioavilability, arbitrarily can dissolve each other with milk, beverage etc., side
Just user takes；Wherein with embodiment 4, embodiment 6 more preferably.
Although, the most with a general description of the specific embodiments the present invention is made
Detailed description, but on the basis of the present invention, it can be made some modifications or improvements, this
Will be apparent to those skilled in the art.Therefore, without departing from present invention spirit
On the basis of these modifications or improvements, belong to the scope of protection of present invention.
Claims (10)
1. the nanoemulsions containing vitamin D linseed oil, it is characterised in that by as follows
The raw material of mass percent prepares: vitamin D 0.02%-1%, linseed oil 1%-10%, breast
Agent 0.5%-3%, antioxidant 0.005%-0.5%, preservative 0.005%-0.5%, surplus is
Water.
Nanoemulsions the most according to claim 1, it is characterised in that described containing vitamin
The nanoemulsions of D linseed oil, is prepared by the raw material of following mass percent: vitamin D
0.2%-0.8%, linseed oil 2%-6%, emulsifying agent 0.8%-1.5%, antioxidant 0.
01%-0.2%, preservative 0.01%-0.2%, surplus is water.
Nanoemulsions the most according to claim 1 and 2, it is characterised in that described emulsification
Agent is selected from soybean lecithin or yolk phospholipid.
Nanoemulsions the most according to claim 1 and 2, it is characterised in that described antioxygen
Agent is selected from ascorbyl palmitate, butylated hydroxy anisole, dibutyl hydroxy toluene, no food
One or more in sub-propyl propionate, tert-butylhydroquinone or tocopherol.
Nanoemulsions the most according to claim 1 and 2, it is characterised in that described anticorrosion
One or more in ethyl-para-hydroxybenzoate, Sodium Benzoate or potassium sorbate of agent.
6. according to the arbitrary described nanoemulsions of claim 1-5, it is characterised in that in Asia
Flaxseed oil adds vegetable oil and is configured to miscella.
7. according to the arbitrary described nanoemulsions of claim 1-6, it is characterised in that described contain
The nanoemulsions particle diameter of vitamin D linseed oil is 5.5-8.3, Zeta electricity less than 600nm, pH
Position is between-36.75V～-13.93mV.
8. a preparation method for the nanoemulsions containing vitamin D linseed oil, its feature exists
In, comprise the steps:
1) prepare aqueous phase: added by emulsifying agent in alkaline water, under nitrogen protection, shear to dividing
Dissipate uniformly；
2) oil phase is prepared: add in linseed oil by vitamin D, antioxidant, preservative,
Add thermal agitation, mixing；
3) oil phase is added in aqueous phase, shear and make colostrum, regulation system pH value to 5.5-8.3；
4) use gradient boost mode to carry out high-pressure homogeneous to colostrum, prepare nanoemulsions.
The preparation method of nanoemulsions the most according to claim 8, it is characterised in that step
Rapid 4), in, described gradient boost is: first carry out 200～400bar low pressure recycle process, then 500～
700bar cycle of higher pressure processes；The temperature that described homogeneous processes controls at 40～60 DEG C.
10. the arbitrary described vitamin D linseed oil nanoemulsions that contains of claim 1-7 is at food
Application in product, field of health care products.
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