CN109588728A - A kind of oral complete nutritional composition - Google Patents
A kind of oral complete nutritional composition Download PDFInfo
- Publication number
- CN109588728A CN109588728A CN201710913813.3A CN201710913813A CN109588728A CN 109588728 A CN109588728 A CN 109588728A CN 201710913813 A CN201710913813 A CN 201710913813A CN 109588728 A CN109588728 A CN 109588728A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- fat
- composition
- emulsifier
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000004615 ingredient Substances 0.000 claims abstract description 22
- 239000000470 constituent Substances 0.000 claims abstract description 18
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 229940088594 vitamin Drugs 0.000 claims abstract description 16
- 229930003231 vitamin Natural products 0.000 claims abstract description 16
- 235000013343 vitamin Nutrition 0.000 claims abstract description 16
- 239000011782 vitamin Substances 0.000 claims abstract description 16
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 14
- 235000015097 nutrients Nutrition 0.000 claims abstract description 9
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 9
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 9
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 7
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000011575 calcium Substances 0.000 claims abstract description 7
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 7
- 239000011574 phosphorus Substances 0.000 claims abstract description 7
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 6
- 239000008213 purified water Substances 0.000 claims abstract description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000011591 potassium Substances 0.000 claims abstract description 4
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 4
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 4
- 239000011669 selenium Substances 0.000 claims abstract description 4
- 239000011734 sodium Substances 0.000 claims abstract description 4
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 3
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims abstract description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000000460 chlorine Substances 0.000 claims abstract description 3
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 3
- 239000010949 copper Substances 0.000 claims abstract description 3
- 229910052802 copper Inorganic materials 0.000 claims abstract description 3
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 3
- 239000011630 iodine Substances 0.000 claims abstract description 3
- 229910052742 iron Inorganic materials 0.000 claims abstract description 3
- 239000011777 magnesium Substances 0.000 claims abstract description 3
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 3
- 229910052748 manganese Inorganic materials 0.000 claims abstract description 3
- 239000011572 manganese Substances 0.000 claims abstract description 3
- 239000011701 zinc Substances 0.000 claims abstract description 3
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 26
- 239000003995 emulsifying agent Substances 0.000 claims description 26
- 239000002562 thickening agent Substances 0.000 claims description 23
- 150000001875 compounds Chemical class 0.000 claims description 21
- 239000000839 emulsion Substances 0.000 claims description 21
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 19
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 18
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 14
- 229930003316 Vitamin D Natural products 0.000 claims description 14
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 14
- 235000019166 vitamin D Nutrition 0.000 claims description 14
- 239000011710 vitamin D Substances 0.000 claims description 14
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 14
- 229940046008 vitamin d Drugs 0.000 claims description 14
- 235000019486 Sunflower oil Nutrition 0.000 claims description 13
- 229930003427 Vitamin E Natural products 0.000 claims description 13
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 13
- 239000001527 calcium lactate Substances 0.000 claims description 13
- 229960002401 calcium lactate Drugs 0.000 claims description 13
- 235000011086 calcium lactate Nutrition 0.000 claims description 13
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 13
- 235000003599 food sweetener Nutrition 0.000 claims description 13
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 13
- 239000002600 sunflower oil Substances 0.000 claims description 13
- 239000003765 sweetening agent Substances 0.000 claims description 13
- 235000019165 vitamin E Nutrition 0.000 claims description 13
- 239000011709 vitamin E Substances 0.000 claims description 13
- 229940046009 vitamin E Drugs 0.000 claims description 13
- 239000005913 Maltodextrin Substances 0.000 claims description 12
- 229920002774 Maltodextrin Polymers 0.000 claims description 12
- 229940035034 maltodextrin Drugs 0.000 claims description 12
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 11
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 11
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 11
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 11
- 125000005456 glyceride group Chemical group 0.000 claims description 11
- 235000012424 soybean oil Nutrition 0.000 claims description 11
- 239000003549 soybean oil Substances 0.000 claims description 11
- 230000001954 sterilising effect Effects 0.000 claims description 11
- 235000019155 vitamin A Nutrition 0.000 claims description 11
- 239000011719 vitamin A Substances 0.000 claims description 11
- 229940045997 vitamin a Drugs 0.000 claims description 11
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 10
- 102000004407 Lactalbumin Human genes 0.000 claims description 10
- 108090000942 Lactalbumin Proteins 0.000 claims description 10
- 239000011706 ferric diphosphate Substances 0.000 claims description 10
- 235000007144 ferric diphosphate Nutrition 0.000 claims description 10
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 claims description 10
- 229940036404 ferric pyrophosphate Drugs 0.000 claims description 10
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 10
- 235000011147 magnesium chloride Nutrition 0.000 claims description 10
- 238000010008 shearing Methods 0.000 claims description 10
- 239000001509 sodium citrate Substances 0.000 claims description 10
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 10
- 239000011691 vitamin B1 Substances 0.000 claims description 10
- 239000011715 vitamin B12 Substances 0.000 claims description 10
- 239000011716 vitamin B2 Substances 0.000 claims description 10
- 239000011726 vitamin B6 Substances 0.000 claims description 10
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 10
- 229960001763 zinc sulfate Drugs 0.000 claims description 10
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 10
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 9
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 9
- 229930003268 Vitamin C Natural products 0.000 claims description 9
- 238000013019 agitation Methods 0.000 claims description 9
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 9
- 229960003512 nicotinic acid Drugs 0.000 claims description 9
- 235000001968 nicotinic acid Nutrition 0.000 claims description 9
- 239000011664 nicotinic acid Substances 0.000 claims description 9
- 235000015921 sodium selenite Nutrition 0.000 claims description 9
- 239000011781 sodium selenite Substances 0.000 claims description 9
- 229960001471 sodium selenite Drugs 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 235000019154 vitamin C Nutrition 0.000 claims description 9
- 239000011718 vitamin C Substances 0.000 claims description 9
- 210000003022 colostrum Anatomy 0.000 claims description 8
- 235000021277 colostrum Nutrition 0.000 claims description 8
- 235000018102 proteins Nutrition 0.000 claims description 8
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 7
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 7
- 229940055726 pantothenic acid Drugs 0.000 claims description 7
- 235000019161 pantothenic acid Nutrition 0.000 claims description 7
- 239000011713 pantothenic acid Substances 0.000 claims description 7
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 6
- 239000004376 Sucralose Substances 0.000 claims description 6
- 229960005069 calcium Drugs 0.000 claims description 6
- 229960000304 folic acid Drugs 0.000 claims description 6
- 235000019152 folic acid Nutrition 0.000 claims description 6
- 239000011724 folic acid Substances 0.000 claims description 6
- 229940099596 manganese sulfate Drugs 0.000 claims description 6
- 239000011702 manganese sulphate Substances 0.000 claims description 6
- 235000007079 manganese sulphate Nutrition 0.000 claims description 6
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 6
- 239000011772 phylloquinone Substances 0.000 claims description 6
- 235000007715 potassium iodide Nutrition 0.000 claims description 6
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 6
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical group O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 6
- 235000019408 sucralose Nutrition 0.000 claims description 6
- 229960002685 biotin Drugs 0.000 claims description 5
- 235000020958 biotin Nutrition 0.000 claims description 5
- 239000011616 biotin Substances 0.000 claims description 5
- 238000004090 dissolution Methods 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- 235000019198 oils Nutrition 0.000 claims description 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 4
- 235000019485 Safflower oil Nutrition 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 235000005713 safflower oil Nutrition 0.000 claims description 3
- 239000003813 safflower oil Substances 0.000 claims description 3
- 229940091258 selenium supplement Drugs 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 240000003183 Manihot esculenta Species 0.000 claims description 2
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 claims description 2
- 239000004383 Steviol glycoside Substances 0.000 claims description 2
- 229940085298 biotin 10 mg Drugs 0.000 claims description 2
- 239000005018 casein Substances 0.000 claims description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
- 235000021240 caseins Nutrition 0.000 claims description 2
- 230000001351 cycling effect Effects 0.000 claims description 2
- 235000003084 food emulsifier Nutrition 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- MBWXNTAXLNYFJB-LKUDQCMESA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-LKUDQCMESA-N 0.000 claims description 2
- 235000019411 steviol glycoside Nutrition 0.000 claims description 2
- 229930182488 steviol glycoside Natural products 0.000 claims description 2
- 150000008144 steviol glycosides Chemical class 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims 2
- 235000020238 sunflower seed Nutrition 0.000 claims 2
- 244000269722 Thea sinensis Species 0.000 claims 1
- 239000005862 Whey Substances 0.000 claims 1
- 102000007544 Whey Proteins Human genes 0.000 claims 1
- 108010046377 Whey Proteins Proteins 0.000 claims 1
- 235000019504 cigarettes Nutrition 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000008719 thickening Effects 0.000 claims 1
- 230000035764 nutrition Effects 0.000 description 11
- 239000012071 phase Substances 0.000 description 8
- 206010001497 Agitation Diseases 0.000 description 7
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
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- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000001376 precipitating effect Effects 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
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- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 2
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- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- DNISEZBAYYIQFB-PHDIDXHHSA-N (2r,3r)-2,3-diacetyloxybutanedioic acid Chemical compound CC(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(C)=O DNISEZBAYYIQFB-PHDIDXHHSA-N 0.000 description 1
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
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- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- FRYDSOYOHWGSMD-UHFFFAOYSA-N [C].O Chemical compound [C].O FRYDSOYOHWGSMD-UHFFFAOYSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 235000003132 food thickener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000013022 formulation composition Substances 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 229960002337 magnesium chloride Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 229960004839 potassium iodide Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to a kind of oral complete nutritional compositions and preparation method thereof, the composition contains liposoluble constituent and non-fat-soluble ingredient and purified water, the non-fat-soluble ingredient that every 1000mL the composition contains is protein 40-60g, carbohydrate 50-120g, sodium 0.5-2g, chlorine 0.4-2.0g, magnesium 0.01-0.6g, phosphorus 0.5-1.5g, potassium 1-4g, calcium 0.3-2g, iron 0.005-0.05g, zinc 0.001-0.05g, copper 0-0.01g, manganese 0-0.01g, selenium 0.01-0.5mg, iodine 0-1.5mg, water soluble vitamin 0.1-2g, the liposoluble constituent contained is fat 40-120g, liposoluble vitamin 0.02-1g, the present invention Involved composition is mainly used to do not have the patient of particular/special requirement to provide comprehensively and the nutritional support of equilibrium to nutrient.
Description
Technical field
The invention belongs to medical food field, it is related to a kind of oral complete nutritional composition and preparation method thereof, is mainly used for
There is no the patient of particular/special requirement to provide comprehensively and the nutritional support of equilibrium nutrient.
Background technique
With the arriving of aging society, in the Health- Ecosystem in the world, number of patients will be gradually increased, wherein greatly
Numerous diseases belong to chronic disease.Therefore, worldwide, new variation is occurring for health field, i.e., is arrived by disease
When take treatment means and be gradually transferred to and preventive treatment of disease.It is also equally, to provide for patient by the theory of science in nutraceutical field
The nutrient formulation of card treats with the common aided disease of drug, can accelerate the recovery of human body technical ability, this theory is in medical body
Play the part of more and more important role in system.Dietetic nutrition, enteral or parenteral nutritional support or nutrition is selected to mend according to patient's state of an illness
The methods of agent is filled, patient is made to obtain suitable nutrition, is the effective way for reducing complication and death.Come from market situation
It sees, enteral nutrition product are all paid attention to very much in developed countries such as America and Europes, and have the considerable market share.The enteral in China
Nutritional market share is also in reduced levels, but with to the continuous understanding of nutrient knowledge and the guidance of policy, China
The amount of consumption of enteral nutrition food is also rising year by year, but also there is a big difference with developed country ratio.From existing carbon hydrate
From the point of view of the kind and quantity of species enteral nutrition food, the several types such as having all nutrition type, assembly type, kind and quantity
It is few, and lean on import more.Therefore, enteral nutrition food in China's has very big market potential.
It has been of crucial importance by the nutrition condition that nutritional support improves clinical patients, but currently on the market
Alternative enteral nutrition food also compares shortage, therefore develops a kind of stable, easy to carry and use, preparation method phase
It is suitble to the complete nutritional composition that takes orally of patient to simple, for not have the clinical patients of particular/special requirement to provide entirely to nutrient
Face and equilibrium nutritional support it is particularly important.
Summary of the invention
It is specific as follows the invention mainly relates to a kind of oral complete nutritional composition and preparation method thereof:
A kind of oral complete nutritional composition, it is characterised in that the composition includes liposoluble constituent, non-fat-soluble ingredient
And purified water；The non-fat-soluble ingredient that composition described in every 1000mL contains is protein 40-60g, carbohydrate 50-
120g, sodium 0.5-2g, chlorine 0.4-2.0g, magnesium 0.01-0.6g, phosphorus 0.5-1.5g, potassium 1-4g, calcium 0.3-2g, iron 0.005-
0.05g, zinc 0.001-0.05g, copper 0-0.01g, manganese 0-0.01g, selenium 0.01-0.5mg, iodine 0-1.5mg, water soluble vitamin
0.1-2g, the liposoluble constituent contained are fat 40-120g, liposoluble vitamin 0.02-1g.
Further, above-mentioned composition also includes emulsifier, compound emulsion thickener and sweetener.
Further, the protein is selected from lactalbumin, casein, hydrolyzing lactoalbumin or its mixing；Carbon hydrate
Object is selected from maltodextrin, tapioca, glucose or its mixing；Fat is selected from sunflower oil, soybean oil, safflower oil or it is mixed
It closes, preferably sunflower oil, soybean oil or its mixing；Water soluble vitamin is selected from pantothenic acid, biotin, vitamin K1, folic acid, dimension life
Plain C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12Or its mixing；Liposoluble vitamin be selected from vitamin E,
Vitamin A, vitamin D or its mixing；The sweetener is selected from Sucralose, steviol glycoside or its mixing；The emulsifier choosing
From single diglyceride, citric acid fatty glyceride or its mixing, optimization citric acid fatty glyceride；The compound emulsion
Thickener is the mixing of food emulsifier and thickener, preferably microcrystalline cellulose, mono-/bis-fatty acid glyceride, gellan gum, hard
The mixing of ester acyl lactylate, diacetyl tartaric acid monodiglyceride, sodium carboxymethylcellulose, further preferred Danisco compounding
Emulsifing thickener 9566-C.
A kind of oral complete nutritional composition, it is characterised in that the composition include liposoluble constituent, non-fat-soluble ingredient,
Sweetener, emulsifier, compound emulsion thickener and purified water, the non-fat-soluble ingredient that composition described in every 1000mL contains are cream
Albumin 40-60g, maltodextrin 50-120g, dipotassium hydrogen phosphate 3-8g, sodium citrate 2-7g, calcium lactate 1.5-10g, magnesium chloride
0.1-5g, ferric pyrophosphate 15-160mg, zinc sulfate 4-222mg, sodium selenite 20-1000 μ g, potassium iodide 0-2mg, manganese sulfate 0-
40mg, copper sulphate 0-40mg, pantothenic acid 0-30mg, biotin 0-20mg, folic acid 0-20mg, vitamin K10-2mg, vitamin C
100-300mg, vitamin B11-5mg, vitamin B21-5mg, niacin 10-20mg, vitamin B60.4-10mg, vitamin
B120.0006-0.3mg, the liposoluble constituent contained are sunflower oil 20-60g, soybean oil 0-40g, vitamin E 30-80mg, tie up
Raw element A 0.1-20mg, vitamin D 20-60 μ g, sweetener 0-0.5g, emulsifier 1-4g, compound emulsion thickener 1-4g.
Further, the non-fat-soluble ingredient that composition described in every 1000mL contains is lactalbumin 55g, maltodextrin
87g, dipotassium hydrogen phosphate 4.5g, sodium citrate 3.6g, calcium lactate 2.2g, magnesium chloride 2.3g, ferric pyrophosphate 50mg, zinc sulfate
50mg, 400 μ g of sodium selenite, potassium iodide 1.3mg, manganese sulfate 2.4mg, copper sulphate 10mg, pantothenic acid 20mg, biotin 10mg, leaf
Sour 10mg, vitamin K10.5mg, vitamin C 240mg, vitamin B12mg, vitamin B22mg, niacin 18mg, vitamin B6
3mg, vitamin B120.1mg, the liposoluble constituent contained are sunflower oil 25g, soybean oil 25g, vitamin E 40mg, vitamin A
2mg, vitamin D 30 μ g, sweetener 0.2g, emulsifier 3g, compound emulsion thickener 1g.
Further, the non-fat-soluble ingredient that composition described in every 1000mL contains is lactalbumin 55g, maltodextrin
87g, dipotassium hydrogen phosphate 4.5g, sodium citrate 3.6g, calcium lactate 2.2g, magnesium chloride 0.3g, ferric pyrophosphate 50mg, zinc sulfate
60mg, 400 μ g of sodium selenite, vitamin C 240mg, vitamin B12mg, vitamin B22mg, niacin 18mg, vitamin B6
1.6mg, vitamin B120.00018mg, the liposoluble constituent contained are sunflower oil 49g, vitamin E 40mg, vitamin A
1mg, vitamin D 30 μ g, sweetener 0.2g, emulsifier 3g, compound emulsion thickener 1g.
Meanwhile the present invention provides the preparation methods of above-mentioned composition comprising the steps of:
Step 1: ingredient
A) non-fat-soluble ingredient, compound emulsion thickener and sweetener are weighed respectively by formula, for use；
B) liposoluble constituent and emulsifier are weighed respectively by formula, for use；
Step 2: dissolution
C) liposoluble constituent claimed and emulsifier heating stirring are obtained into oil-phase solution to Quan Rong；
D) the non-fat-soluble component protein matter and carbohydrate that claim is dry-mixed, with the water 50-80 for preparing total amount 60%
DEG C water temperature shear agitation is to Quan Rong；Compound emulsion thickener, shear agitation to Quan Rong is added；
E) the remaining non-fat-soluble ingredient in addition to water soluble vitamin claimed is added into step d) solution, stirs evenly；
Step 3: step c) solution is slowly added into step e) solution with high shear revolving speed, continues cycling through shearing 30min,
The water soluble vitamin of 5min addition water dissolution, shearing are uniform before shearing terminates；
Step 4: it is 6.0-7.0 that dipotassium hydrogen phosphate, which adjusts product pH,；
Step 5: being settled to preparation total volume, colostrum is made；
Step 6: by colostrum self-loopa made from step 4；It is settled to total volume, is cooled to 20 DEG C or less；
Step 7: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilizings 10~
It is 30 seconds, filling.
In addition, the invention further relates to the compositions to be used to not have nutrient patient's offer of particular/special requirement comprehensive and equal
The application of the nutritional support of weighing apparatus.
The present invention has found that the selection of emulsifier is very big on product stability influence, and emulsifier selects not in R&D process
When can then generate a large amount of precipitatings and/or oil slick, there is lamination, seriously then leads to product denaturation solidification, therefore to emulsifier
Selection has carried out experimental study:
By the emulsifier citric acid fatty glyceride filtered out and single diglyceride, thickened respectively with the emulsification of compounding
Agent is used together, and Product Status is more steady when citric acid fatty glyceride is used together with compound emulsion thickener as the result is shown
Fixed, (40 DEG C of temperature, humidity: 70%) placing 6 months products is in uniform liquid, and a small amount of precipitating is arranged at bottom, but rocks and disappear for acceleration
It loses.
In addition, the source selection of calcium is also very big to the stability influence of product, to calcium chloride, calcium carbonate, calcium monohydrogen phosphate, cream
Sour calcium carries out sample preparation screening:
By the calcium lactate filtered out and calcium monohydrogen phosphate, sample is prepared, accelerate (40 DEG C of temperature, humidity: 70%) placement 6
Month, wherein the Product Status of selection calcium lactate is uniform, the only a small amount of precipitating in Packaging Bottle bottom slightly shakes and disappears, than adding phosphorus
The product of sour hydrogen calcium is more stable.
Meanwhile in formula potassium dihydrogen phosphate content selection it is more important, it is ensured that the content of phosphorus and potassium, while to make to produce
Product pH is within prescribed limit 6.0-7.0.
Oral complete nutritional composition according to the present invention, can be more while nutritional support is provided in the treatment to patient
Patients ' recovery is helped well, reduces the generation of complication, is the full nutrient formulation composition suitable for most of clinical patients, leads to
Various nutriments needed for the modes such as oral or nasal feeding provide comprehensive, sufficient body for patient are crossed, to reach prevention or correction
Heat, protein lack caused underfed purpose, while playing enhancing patient to the tolerance of severe trauma, promote disease
The effect of people's rehabilitation.
Present composition nutrition general equilibrium is suitble to the overwhelming majority not have the patient of specific demand to nutrient, is rich in
High monounsaturated fatty acids sunflower oil, soybean oil, safflower oil or its mixing, are effectively improved glycolipid metabolism；Protein content reaches
4%, the reparation of cell and tissue can be promoted.Each component content meets regulation in composition in the present invention；Due to having selected lemon
Lemon acid fatty glyceride controls the amount of dipotassium hydrogen phosphate, makes product as emulsifier, source of the calcium lactate as calcium
Stability is high；This product is easy to carry and use simultaneously, and preparation method is simple, at low cost, is convenient for industrialized production.
Specific embodiment
Below will by embodiment, the invention will be further described, these description be not the content of present invention is made into
The restriction of one step.Those skilled in the art still falls within protection of the invention to equivalent replacement made by summary of the invention or improvement
Within the scope of.
Embodiment 1:
Preparation process:
Step 1: ingredient
1) good each non-fat-soluble material lactalbumin, maltodextrin, sodium citrate, magnesium chloride, phosphorus are weighed respectively by formula
Sour hydrogen dipotassium, calcium lactate, ferric pyrophosphate, zinc sulfate, copper sulphate, manganese sulfate, sodium selenite, potassium iodide, pantothenic acid, biotin, dimension
Raw element K1, folic acid, vitamin C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, vitamin A, vitamin D,
Vitamin E, compound emulsion thickener, Sucralose, for use；
2) weighed respectively by formula good fat-soluble material sunflower oil, soybean oil, emulsifier citric acid fatty glyceride,
Vitamin A, vitamin D, vitamin E, for use；
3) it is added in material-compound tank and prepares 60% water of total amount, for use；
Step 2: dissolution
1) by the sunflower oil weighed up, soybean oil, emulsifier citric acid fatty glyceride, vitamin A, vitamin D, dimension
Raw element E heating stirring obtains oil-phase solution to Quan Rong；
2) albumen weighed up, maltodextrin is dry-mixed good, put into material-compound tank, 70 DEG C or so water temperature shear agitations to Quan Rong；
3) compound emulsion thickener, Sucralose are put into material-compound tank again, respectively shear agitation to Quan Rong；
4) spare magnesium chloride, sodium citrate, calcium lactate, manganese sulfate, copper sulphate, potassium iodide, zinc sulfate, sub- selenium will be weighed up
Sour sodium, ferric pyrophosphate, dipotassium hydrogen phosphate, then be separately added into above-mentioned aqueous phase solution, it stirs evenly；
Step 3: water phase being set under cutter, oily phase is slowly added to high shear revolving speed, oil continues to follow after being added to
Ring shears about 30min, and for 5min by water-soluble good, the investment material-compound tank of all water soluble vitamins, shearing is equal before shearing terminates
It is even；
Step 4: being settled to preparation total volume, stir evenly obtained colostrum；
Step 5: by the colostrum obtained first self-loopa in material-compound tank, after homogeneous parameter mixes up, then homogeneous arrives another
Jar empties the feed liquid that non-homogeneous remaining in tank arrives；Above-mentioned feed liquid is settled to total volume later, is cooled to 20 DEG C or less；
Step 6: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilizings 10~
It is 30 seconds, filling.
Stability test:
Embodiment 2
Preparation process:
Step 1: ingredient
1) good each non-fat-soluble material lactalbumin, maltodextrin, sodium citrate, magnesium chloride, phosphorus are weighed respectively by formula
Sour hydrogen dipotassium, calcium lactate, ferric pyrophosphate, zinc sulfate, sodium selenite, vitamin C, vitamin B1, vitamin B2, niacin, vitamin
B6, vitamin B12, vitamin A, vitamin D, vitamin E, compound emulsion thickener, Sucralose, for use；
2) good fat-soluble material sunflower oil, emulsifier citric acid fatty glyceride, vitamin are weighed respectively by formula
A, vitamin D, vitamin E, for use；
3) it is added in material-compound tank and prepares 60% water of total amount, for use；
Step 2: dissolution
1) sunflower oil weighed up, emulsifier citric acid fatty glyceride, vitamin A, vitamin D, vitamin E are added
Thermal agitation obtains oil-phase solution to Quan Rong；
2) albumen weighed up, maltodextrin is dry-mixed good, put into material-compound tank, 70 DEG C or so water temperature shear agitations to Quan Rong；
3) compound emulsion thickener, Sucralose are put into material-compound tank again, respectively shear agitation to Quan Rong；
4) will weigh up spare magnesium chloride, sodium citrate, calcium lactate, copper sulphate, zinc sulfate, sodium selenite, ferric pyrophosphate,
Dipotassium hydrogen phosphate, then be separately added into above-mentioned aqueous phase solution, it stirs evenly；
Step 3: water phase being set under cutter, oily phase is slowly added to high shear revolving speed, oil continues to follow after being added to
Ring shears about 30min, and for 5min by water-soluble good, the investment material-compound tank of all water soluble vitamins, shearing is equal before shearing terminates
It is even；
Step 4: being settled to preparation total volume, stir evenly obtained colostrum；
Step 5: by the colostrum obtained first self-loopa in material-compound tank, after homogeneous parameter mixes up, then homogeneous arrives another
Jar empties the feed liquid that non-homogeneous remaining in tank arrives；Above-mentioned feed liquid is settled to total volume later, is cooled to 20 DEG C or less；
Step 6: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilizings 10~
It is 30 seconds, filling.
Stability test:
Embodiment 3-5
Preparation process: with embodiment 1
Stability test testing result and embodiment 1 and 2 compare within the scope of allowable error.
Claims (10)
1. a kind of oral complete nutritional composition, it is characterised in that the composition include liposoluble constituent, non-fat-soluble ingredient and
Purified water；The non-fat-soluble ingredient that composition described in every 1000mL contains be protein 40-60g, carbohydrate 50-120g,
Sodium 0.5-2g, chlorine 0.4-2.0g, magnesium 0.01-0.6g, phosphorus 0.5-1.5g, potassium 1-4g, calcium 0.3-2g, iron 0.005-0.05g, zinc
0.001-0.05g, copper 0-0.01g, manganese 0-0.01g, selenium 0.01-0.5mg, iodine 0-1.5mg, water soluble vitamin 0.1-2g, contain
Some liposoluble constituents are fat 40-120g, liposoluble vitamin 0.02-1g.
2. composition as described in claim 1, it is characterised in that also include emulsifier, compound emulsion thickener and sweetener.
3. composition as claimed in claim 1 or 2, it is characterised in that the protein is selected from lactalbumin, casein, hydrolysis
Lactalbumin or its mixing；Carbohydrate is selected from maltodextrin, tapioca, glucose or its mixing；Fat is selected from sunflower
Seed oil, soybean oil, safflower oil or its mixing；Water soluble vitamin is selected from pantothenic acid, biotin, vitamin K1, folic acid, vitamin C,
Vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12Or its mixing；Liposoluble vitamin is selected from vitamin E, dimension life
Plain A, vitamin D or its mixing；The sweetener is selected from Sucralose, steviol glycoside or its mixing；The emulsifier is selected from single
Diglyceride, citric acid fatty glyceride or its mixing；The compound emulsion thickener is food emulsifier and thickening
The mixing of agent.
4. composition as claimed in claim 3, it is characterised in that the protein is lactalbumin；The fat is sunflower seeds
Oil, soybean oil or its mixing；The emulsifier is citric acid fatty glyceride.
5. a kind of oral complete nutritional composition, it is characterised in that the composition includes liposoluble constituent, non-fat-soluble ingredient, sweet tea
Taste agent, emulsifier, compound emulsion thickener and purified water, the non-fat-soluble ingredient that composition described in every 1000mL contains are whey
Albumen 40-60g, maltodextrin 50-120g, dipotassium hydrogen phosphate 3-8g, sodium citrate 2-7g, calcium lactate 1.5-10g, magnesium chloride
0.1-5g, ferric pyrophosphate 15-160mg, zinc sulfate 4-222mg, sodium selenite 20-1000 μ g, potassium iodide 0-2mg, manganese sulfate 0-
40mg, copper sulphate 0-40mg, pantothenic acid 0-30mg, biotin 0-20mg, folic acid 0-20mg, vitamin K10-2mg, vitamin C
100-300mg, vitamin B11-5mg, vitamin B21-5mg, niacin 10-20mg, vitamin B60.4-10mg, vitamin
B120.0006-0.3mg, the liposoluble constituent contained be sunflower oil 20-60g, soybean oil 0-40g, vitamin E 30-80mg,
Vitamin A 0.1-20mg, vitamin D 20-60 μ g, sweetener 0-0.5g, emulsifier 1-4g, compound emulsion thickener 1-4g.
6. composition as claimed in claim 5, it is characterised in that the non-fat-soluble ingredient that composition described in every 1000mL contains
For lactalbumin 55g, maltodextrin 87g, dipotassium hydrogen phosphate 4.5g, sodium citrate 3.6g, calcium lactate 2.2g, magnesium chloride 2.3g,
Ferric pyrophosphate 50mg, zinc sulfate 50mg, 400 μ g of sodium selenite, potassium iodide 1.3mg, manganese sulfate 2.4mg, copper sulphate 10mg, pantothenic acid
20mg, biotin 10mg, folic acid 10mg, vitamin K10.5mg, vitamin C 240mg, vitamin B12mg, vitamin B22mg、
Niacin 18mg, vitamin B63mg, vitamin B120.1mg, the liposoluble constituent contained be sunflower oil 25g, soybean oil 25g,
Vitamin E 40mg, vitamin A 2mg, vitamin D 30 μ g, sweetener 0.2g, emulsifier 3g, compound emulsion thickener 1g.
7. composition as claimed in claim 5, it is characterised in that the non-fat-soluble ingredient that composition described in every 1000mL contains
For lactalbumin 55g, maltodextrin 87g, dipotassium hydrogen phosphate 4.5g, sodium citrate 3.6g, calcium lactate 2.2g, magnesium chloride 0.3g,
Ferric pyrophosphate 50mg, zinc sulfate 60mg, 400 μ g of sodium selenite, vitamin C 240mg, vitamin B12mg, vitamin B22mg, cigarette
Sour 18mg, vitamin B61.6mg, vitamin B120.00018mg, the liposoluble constituent contained are sunflower oil 49g, vitamin E
40mg, vitamin A 1mg, vitamin D 30 μ g, sweetener 0.2g, emulsifier 3g, compound emulsion thickener 1g.
8. the preparation method of any one of claim 1-7 composition, it is characterised in that comprise the steps of:
Step 1: ingredient
A) non-fat-soluble ingredient, compound emulsion thickener and sweetener are weighed respectively by formula, for use；
B) liposoluble constituent and emulsifier are weighed respectively by formula, for use；
Step 2: dissolution
C) liposoluble constituent claimed and emulsifier heating stirring are obtained into oil-phase solution to Quan Rong；
D) the non-fat-soluble component protein matter and carbohydrate that claim is dry-mixed, with the 50-80 DEG C of water of water for preparing total amount 60%
Warm shear agitation is to Quan Rong；Compound emulsion thickener, shear agitation to Quan Rong is added；
E) the remaining non-fat-soluble ingredient in addition to water soluble vitamin claimed is added into step d) solution, stirs evenly；
Step 3: step c) solution being slowly added into step e) solution with high shear revolving speed, continues cycling through shearing 30min, shearing
The water soluble vitamin that 5min addition is dissolved with water before terminating, shearing are uniform；
Step 4: adjusting product pH with alkali is 6.0-7.0；
Step 5: being settled to preparation total volume, colostrum is made；
Step 6: by colostrum self-loopa made from step 4；It is settled to total volume, is cooled to 20 DEG C or less；
Step 7: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilize 10~30 seconds,
It is filling.
9. preparation method according to claim 8, it is characterised in that alkali described in step 4 is dipotassium hydrogen phosphate.
10. composition of any of claims 1-8 there is no particular/special requirement to nutrient patient provide comprehensively and
The application of balanced nutritional support.
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| CN116349875A (en) * | 2023-04-07 | 2023-06-30 | 南京师范大学 | Oral total nutrient composition and preparation method thereof |
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