CN107536938A - A kind of vital energy regualting and blood circulation-promoting preparation is preparing the application in treating or preventing renal damage medicine - Google Patents
A kind of vital energy regualting and blood circulation-promoting preparation is preparing the application in treating or preventing renal damage medicine Download PDFInfo
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Abstract
The invention discloses a kind of application of vital energy regualting and blood circulation-promoting preparation in treatment or prevention renal damage medicine is prepared, vital energy regualting and blood circulation-promoting preparation of the invention is made up of Fructus cinnamomi camphorae, Longstamen Onion Bulb, Ligusticum wallichii and borneol four traditional Chinese medicine；The vital energy regualting and blood circulation-promoting preparation of the present invention has obvious downward effect to serum creatinine caused by renal damage (Scr), urea nitrogen (BUN) and MDA rise, and there is obvious up-regulation to act on to SOD activity decreases caused by renal damage.Clinical test shows that vital energy regualting and blood circulation-promoting preparation of the present invention is used to treat the efficient height of renal damage, and good effect, the treatment for renal damage provides new therapy approach and expanded the clinical practice of vital energy regualting and blood circulation-promoting preparation.
Description
Technical field
The invention belongs to pharmaceutical technology field, is specifically related to a kind of vital energy regualting and blood circulation-promoting preparation and is preparing treatment or prevention kidney damage
Application in evil medicine.
Technical background
Kidney is the important excretory organs of human body.Renal damage refers to the glomerulus as caused by many factors and renal tubular function
Property, structural infringement, the very big reduction of the main double renal excretions filtering body waste abilities of performance is clinically a kind of common
Disease.The main pathogenic factor of acute renal injury (AKI) is that renal perfusion amount is reduced, and causes glomerular filtration rate(GFR to reduce, so as to draw
Play renal ischemia and reperfusion injury.Renal lesion is had no in this process early stage, can be inverse if intervention can be carried out in time
Turn the infringement of haemodynamics, renal function is recovered rapidly.The acute renal injury incidence of disease is still in very high level at present.Slowly
Property kidney trouble (CKD) is chronic Renal Structure and dysfunction as caused by a variety of causes, and various kidney troubles are such as without having
Effect treatment, occurs chronicity and is developed to chronic renal failure.CKD is seriously endanger human health and life common
Disease, due to a lack of earlier evaluations and the index of monitoring, it drastically influence CKD treatment and prognosis.Renal blood flow enriches, and is important
Drug metabolism place, and the excretory organs of most drug and its metabolin.Due to dissection and physiologically the characteristics of, kidney
It is particularly susceptible to the infringement of dealed with medicine went.According to statistics, 20% adult acute's renal failure is drug-induced.
Drug-induced renal impairment refer to be exposed to after toxicity or genotoxic potential medicine, cause double kidneys or one of infringement, there is urine examination
Abnormal (showing as blood urine, albuminuria and cylindruria), Pathological textural anomaly (renal cells denaturation, oedema, necrosis
Deng) and renal dysfunction (serum creatinine raise or glomerular filtration rate(GFR reduce) disease.Drug-induced renal impairment incidence in recent years
Gradually step up, it has also become the whole world causes one of major reason of death, increasingly attracts people's attention.
Vital energy regualting and blood circulation-promoting preparation is to extract it by Fructus cinnamomi camphorae, Longstamen Onion Bulb, Ligusticum wallichii and borneol for primary raw material to have medicinal valency
Manufactured preparation, patent CN03135734.2, entitled " treatment coronary heart disease, the heart are made as active ingredient for the extract of value
The Chinese medicine preparation and preparation method of angina " and patent CN201010562944.x, a kind of entitled " coronary disease and angina pectoris for the treatment of
Pharmaceutical composition and its preparation method and preparation " disclose vital energy regualting and blood circulation-promoting preparation prescription with and preparation method thereof.
For the principle of reatment of renal damage clinically based on expectant treatment, therapeutic purposes are to protect functional to greatest extent
Nephridial tissue, the overwhelming majority take non-operative treatment.Vital energy regualting and blood circulation-promoting preparation is main by Fructus cinnamomi camphorae, Longstamen Onion Bulb, Ligusticum wallichii and borneol
Raw material is made, and has the effect of Wen Yangkuan chests, vital energy regualting and blood circulation-promoting, is used clinically for coronary heart disease stable type angina pectoris I, II
Level deficiency of heart-YANG, heart blood silt, symptoms include uncomfortable in chest, pectoralgia, palpitaition, shortness of breath, shape are trembled with fear, and tongue nature is light or dark, and tongue fur is white, deep thready pulse.
Research shows that vital energy regualting and blood circulation-promoting preparation has analgesia, the calm, pharmacological action of resist oxygen lack.But so far, have no that qi-regulating is lived
Blood preparation is used for research and the report for treating and preventing injury of kidney related fields.The applicant has found in subsequent research, manages
Gas Huoxue preparation can be also used for preventing or treat renal damage disease.
The content of the invention
It is an object of the invention to provide a kind of vital energy regualting and blood circulation-promoting preparation to prepare the application in treating or preventing renal damage medicine.
A kind of application of the vital energy regualting and blood circulation-promoting preparation of the present invention in treatment or prevention renal damage medicine is prepared includes：Reason
Gas Huoxue preparation is preparing the application in treating or preventing acute renal injury, Chronic Kidney Disease, drug-induced renal impairment medicine.
The vital energy regualting and blood circulation-promoting preparation of the present invention is made up of Fructus cinnamomi camphorae, Longstamen Onion Bulb, Ligusticum wallichii and borneol, in parts by weight
Calculate, vital energy regualting and blood circulation-promoting preparation of the present invention is by weight ratio：Fructus cinnamomi camphorae 350-600 parts, Longstamen Onion Bulb 25-50 parts, river
Rhizome of chuanxiong 250-500 parts, borneol 4-15 parts.
Preferably proportioning is：Fructus cinnamomi camphorae 400-500 parts, Longstamen Onion Bulb 30-40 parts, Ligusticum wallichii 300-400 parts, borneol 8-11
Part.
More preferably proportioning is：450 parts of Fructus cinnamomi camphorae, 36 parts of Longstamen Onion Bulb, 360 parts of Ligusticum wallichii, 9 parts of borneol.
Foregoing vital energy regualting and blood circulation-promoting preparation be tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule,
Soft capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, paste, sublimed preparation, supensoid agent, pulvis, solution, note
Penetrate agent, suppository, spray, pill, patch.
Preferably, foregoing vital energy regualting and blood circulation-promoting preparation is pill.
Foregoing vital energy regualting and blood circulation-promoting preparation containing conventional excipient, such as adhesive, filler, tablet agent, diluent,
Wetting agent, disintegrant, colouring agent, flavor enhancement, wetting agent and medicinal carrier material.
Vital energy regualting and blood circulation-promoting preparation of the present invention is made up of Fructus cinnamomi camphorae, Longstamen Onion Bulb, Ligusticum wallichii and borneol, and Fructus cinnamomi camphorae is again
Name rice is withered, is the dry fruit of Lauraceae cinnamon, and it has the higher volatile oil of content, and its chemical composition is mainly monoterpene or again
Half terpene；The property of medicine taste：It is pungent-warm, nontoxic；With eliminating cold to remove dampness, promoting qi circulation and relieving pain effect.Longstamen Onion Bulb is Liliaceae allium rootlet
Garlic or the dry bulb of Chinese onion；Nature and flavor acrid, bitter, warm, has middle benefit gas to activate yang, the wide chest of qi-regulating, the effect of activating yang and removing abstruction.Ligusticum wallichii is Umbelliferae
The rhizome of Jehol Ligusticum Rhizome platymiscium Ligusticum wallichii, warm-natured, acrid flavour, slight bitter, for conventional Chinese medicine promoting blood circulation and removing blood stasis its contain volatile oil, alkaloid,
Phenolic substance, organic acid, phthalide lactone and other etc. composition；The effect of with blood-activating and qi-promoting, wind-expelling pain-stopping.Borneol is kapur
The processed goods of section's plant Borneolum Syntheticum resin, or the crystallization of feverfew Blumea balsamifera leaf extraction, or with turpentine oil, camphor etc. for raw material
Highly finished product through being chemically synthesized；The main component of borneol is d-Bomeol, and L-Borneol is mainly L-Borneol, borneol
It is pungent, bitter, be slightly cold.The thoughts of returning home, spleen, lung channel, there is the effect of inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.Vital energy regualting and blood circulation-promoting preparation by Fructus cinnamomi camphorae,
Longstamen Onion Bulb, Ligusticum wallichii and borneol composition, have the effect of Wen Yangkuan chests, vital energy regualting and blood circulation-promoting, are clinically used for coronary heart disease stable type labor
Tired property angina pectoris I, II grade of deficiency of heart-YANG, heart blood silt.The applicant has found that vital energy regualting and blood circulation-promoting preparation may be used also by experimental study
For preparing the medicine for treating or preventing renal damage.
In order that those of ordinary skill in the art are better understood from the present invention, this is expanded on further below by way of experimental example
The composition and preparation method of invention vital energy regualting and blood circulation-promoting preparation, and vital energy regualting and blood circulation-promoting preparation is in treatment or prevention renal damage medicine is prepared
Experimental study.It should be noted that：Following examples are only to explain the present invention, rather than the limitation present invention.
Test example 1：Protective effect of the vital energy regualting and blood circulation-promoting preparation to test-type renal damage
1.1 test material
1.1.1 medicine and reagent
Vital energy regualting and blood circulation-promoting dripping pill：It is derived from embodiment 1-7 vital energy regualting and blood circulation-promoting dripping pills as made from different prescriptions proportioning；Ligustrazine Hydrochloride
Parenteral solution：Henan Furen Huaiqingtang Pharmaceutical Co., Ltd. produces；Doxorubicin hydrochloride：Haizheng Medicine Stock Co., Ltd., Zhejiang Prov gives birth to
Production, is measured as 10mg/ml；Creatinine detection reagent box, Urea nitrogen detection reagent box, MDA detection kit, superoxides discrimination
Change enzyme detection kit, glutathione peroxidase detection kit：Nanjing Ju Li bioengineering Co., Ltd provides.
1.1.2 experimental animal
Wistar male rats, body weight 180-220g, provided by Medical School of Zhengzhou University Experimental Animal Center.
1.1.3 instrument
721 type spectrophotometers：The analytical instrument factory of Shanghai the 3rd；Liquid flash mixer:The types of YKH-II：Jiangxi medical treatment
Apparatus factory；Constant water bath box：Xiamen medical electronics factory；Normal speed centrifuge：Beijing Medical Instruments factory.
1.2 test method
1.2.1 prepared by experimental animal model and packet is administered
Improved on the basis of Bertarnim, after rat rests 5, in the state of not anaesthetizing, disposable tail vein
Inject doxorubicin hydrochloride 6.5mgkg-1, prepare adriamycin and cause rat kidney infringement model.
Wistar male rats 100 are taken, are randomly divided into normal group (without any processing), (NS groups, give physiological saline group
Pharmaceutical quantities NS4mL), Ligustrazine Hydrochloride Injection group (positive controls, dosage 0.4g。kg-1·d-1, be injected intraperitoneally to
Medicine), vital energy regualting and blood circulation-promoting dripping pill group (treatment group, dosage are 3 balls, are treatment group 1-7 by embodiment 1-7 points, gastric infusion),
It is administered daily 1 time, continuous 5d, all animals anaesthetize down-sampling on 6th after the 1st administration in yellow Jackets.
1.2.2 the preparation of sample
The preparation of blood cytolysate：With syringe (heparin moistening) from femoral artery blood drawing 1mL, 10mL centrifuge tubes are added
It is interior, 5min (2000rmin are centrifuged after gently being rinsed with 5mL physiological saline-1), suck supernatant and add normal saline to rush again
Wash, centrifuge, be so repeated 3 times.Take the μ L of red blood cell 20 after washing to add in 3mL distilled waters fully after haemolysis, it is standby to put 4 DEG C of refrigerators
With.
The preparation of serum:Femoral artery takes blood 4mL, after blood clotting, centrifuges 10min (3000rmin-1), take serum to put
4 DEG C of refrigerators are standby.
The preparation of lipid peroxicition homogenate:Cut open the belly it is rapid take out kidney, put that -30 DEG C of refrigerators are quick-frozen, will be quick-frozen after kidney
Take out, lipid peroxicition 0.5g is cut under ice bath, add 4.5mL PBS liquid and (pH7.4,0.1mM, it is pre- to add preposition 4 DEG C of refrigerators
It is cold), put in tissue homogenizer and grind repeatedly, 10% lipid peroxicition homogenate is made, it is standby to put 4 DEG C of refrigerators.
1.2.3 the measure of sample
Scr measure uses picric acid method, and BUN measure uses diacetyl monoxime method, and MDA measure is using vulcanization barbiturates
(TBA) method, SOD determinations of activity are operated by kit.
1.3 result of the test
1.3.1 to blood serum Bun, the influence of BUN contents
NS groups Scr, BUN compared with normal group is significantly raised, there were significant differences (P<0.05) modeling success, is shown；Treatment
Group 2-7, positive controls Scr, BUN compared with NS groups are substantially reduced, there were significant differences (P<0.05), show treatment group 2-7 and
Positive controls can protect renal damage；Treatment group 1 is low component, and Scr, BUN reduce unobvious compared with NS groups, and difference does not show
Write (P>0.05)；Reduction effects of the treatment group 2-7 to Scr, BUN is better than positive controls；Drops of the treatment group 2-4 to Scr, BUN
Low effect is significantly strengthened, and reduction effects of the treatment group 4-6 to Scr, BUN is slowly strengthened, and treatment group 6 is right compared with treatment group 7
Scr, BUN reduction effect are almost no longer strengthened；Accordingly, it is preferred that component proportion is Fructus cinnamomi camphorae 350-600 parts, Longstamen Onion Bulb
25-50 parts, Ligusticum wallichii 250-500 parts, borneol 4-15 parts.
The blood serum Bun of table 1 and BUN testing results (x ± s, n=10)
| Component | Scr(μmol/L) | BUN(mmol/L) |
| Normal group | 22.83±1.72 | 6.43±0.96 |
| NS groups | 40.25±1.56 | 19.25±1.42 |
| Positive controls | 28.38±1.64 | 12.24±0.49 |
| Treatment group 1 (embodiment 1) | 33.23±2.01 | 14.56±1.04 |
| Treatment group 2 (embodiment 2) | 27.56±0.89 | 11.22±0.73 |
| Treatment group 3 (embodiment 3) | 25.43±1.42 | 9.47±0.93 |
| Treatment group 4 (embodiment 4) | 24.08±1.16 | 7.25±0.64 |
| Treatment group 5 (embodiment 5) | 23.56±0.97 | 6.54±0.78 |
| Treatment group 6 (embodiment 6) | 22.89±1.25 | 6.09±0.63 |
| Treatment group 7 (embodiment 7) | 22.72±1.34 | 6.01±0.79 |
1.3.2 to the influence of erythrocyte sod activity and Content of MDA
NS groups Content of MDA compared with normal group is significantly raised, and erythrocyte sod activity is obvious to be reduced, and there were significant differences
(P<0.05)；Treatment group 2-7, the positive controls Content of MDA compared with NS groups substantially reduce, and erythrocyte sod activity is obvious
Rise, there were significant differences (P<0.05)；Treatment group 1 is low component, and Content of MDA reduces unobvious compared with NS groups, red thin
Born of the same parents SOD activity rise unobvious, the not notable (P of difference>0.05)；Treatment group 2-7 is reduced to Content of MDA, erythrocyte sod is lived
Property rise effect be better than positive controls；Treatment group 2-4 reduces to Content of MDA, the rise of erythrocyte sod activity acts on significantly
Degree is strengthened, and treatment group 4-6 reduces to Content of MDA, erythrocyte sod activity rise effect is slowly strengthened, treatment group 6 and treatment
Group 7 is compared, and Content of MDA is reduced, erythrocyte sod activity rise effect is almost no longer strengthened；Accordingly, it is preferred that group distribution
Than for Fructus cinnamomi camphorae 350-600 parts, Longstamen Onion Bulb 25-50 parts, Ligusticum wallichii 250-500 parts, borneol 4-15 parts.
The erythrocyte sod of table 2 activity and Content of MDA (x ± s, n=10)
1.3.3 to the influence of lipid peroxicition SOD activity and MDA contents
NS groups MDA contents compared with normal group are significantly raised, and SOD activity is obvious to be reduced, there were significant differences (P<0.05)；Control
Treatment group 2-7, positive controls the MDA contents compared with NS groups substantially reduce, SOD activity is significantly raised, and there were significant differences (P<
0.05)；Treatment group 1 is low component, and MDA contents reduce unobvious, SOD activity rise unobvious compared with NS groups, and difference does not show
Write (P>0.05)；Treatment group 2-7 reduces to MDA contents, SOD activity rise effect is better than positive controls；2-4 pairs for the treatment of group
MDA contents reduce, SOD activity rise effect is significantly strengthened, and treatment group 4-6 reduces to MDA contents, the rise of SOD activity acts on
Slowly strengthen, treatment group 6 reduces, SOD activity rise effect is almost no longer strengthened compared with treatment group 7 to MDA contents；Therefore,
Preferable component proportion is Fructus cinnamomi camphorae 350-600 parts, Longstamen Onion Bulb 25-50 parts, Ligusticum wallichii 250-500 parts, borneol 4-15 parts.
The lipid peroxicition SOD of table 3 activity and Content of MDA (x ± s, n=10)
1.4 conclusion (of pressure testing)
Positive drug Ligustrazine Hydrochloride Injection and vital energy regualting and blood circulation-promoting dripping pill (being made by embodiment 2-6) energy increased SOD activity,
MDA, Scr, BUN content are reduced, shows that vital energy regualting and blood circulation-promoting preparation of the present invention has renal damage protective effect.
Test example 2：Vital energy regualting and blood circulation-promoting preparation for treating renal damage clinical research
2.1 case selection
100 are diagnosed as Patients with Renal Damage, Chronic Kidney Disease patient 10, acute renal injury patient 50, Drug kidney damage
Evil patient 40.Wherein male 70, women 30, age 25-90 year, average age 59.25 years old.Younger group 9 (9%),
Middle age group 20 (20%), old age group 71 (71%).It is divided into two groups by random parallel method, treatment group 55, control group
45.Two groups of patient ages compare, no significant difference (P>0.05).
2.2 treatment method
The oral vital energy regualting and blood circulation-promoting dripping pill for the treatment of group patient, 10 ball every time, 3 times a day.The oral Function of Yishen Jiedu Capsule of control group, often
Secondary 8, three times per day.Continuously take two weeks.
2.3 observation index and clinical efficacy criterion
The 14th day ratio (MAB/C) for checking microdose urine protein and creatinine, urine N- acetyl-β-D- aminoglucoses after treatment
The ratio (NAG/C) of glycosidase, blood urea nitrogen (BUN), serum creatinine (Scr) index.
It is effective：Clinical symptoms substantially mitigate or disappeared, and the ratio (MAB/C) of microdose urine protein and creatinine, urine N- acetyl-
The ratio (NAG/C) of β-D- UNAGs declines >=30%, and blood urea nitrogen (BUN), serum creatinine (Scr) decline >=
20%.Effectively：Ratio (MAB/C), the urine N- acetyl-β-D- aminoglucoses of clinical symptom relief, microdose urine protein and creatinine
The ratio (NAG/C) of glycosidase declines >=20%, and blood urea nitrogen (BUN), serum creatinine (Scr) decline >=10%. are invalid：Clinical condition
Shape is without improving or aggravate, the ratio (MAB/C) of microdose urine protein and creatinine, guanoside drugs
Ratio (NAG/C) declines<20%, blood urea nitrogen (BUN), serum creatinine (Scr) decline<10%.
All data are handled using the statistical softwares of SPSS 11.0.Two groups of patient ages and DDP amounts are examined using t, MAB/C,
Urinary NAG/C significant difference uses rank test, and BUN, SCr change use X2Examine.
2.4 result
Treatment group's total effective rate is 94.55%, and control group total effective rate is 82.22%, and treatment group is efficient higher than control
Group is efficient.
The comparison of 4 two groups of clinical efficacies of table
| Group | Number of cases | It is effective | Effectively | It is invalid |
| Treatment group | 55 | 23 (41.82%) | 29 (52.73%) | 3 (5.45%) |
| Control group | 45 | 15 (33.33%) | 22 (48.89%) | 8 (17.78%) |
2.5 conclusion
Vital energy regualting and blood circulation-promoting dripping pill is better than Function of Yishen Jiedu Capsule to the therapeutic effect of renal damage, and effective percentage shows up to 94.55%
Vital energy regualting and blood circulation-promoting dripping pill treatment renal damage has the effect of good and potential therapeutic value.
Embodiment：
Embodiment 1：The preparation technology (low component) of vital energy regualting and blood circulation-promoting dripping pill
Prescription：Fructus cinnamomi camphorae 300g, Longstamen Onion Bulb 20g, Ligusticum wallichii 200g, borneol 3g；
(1), rice is withered is ground into coarse powder, crosses 24 mesh sieves, adds 8 times of amount 75% ethanol immersions, and soak time is：7 hours, surpass
Sound wave extracts 80 minutes, filters, and collects filtrate, and vapor steams the solvent in filtrate, obtains Cinnamoman Migao H.W.Li, and the dregs of a decoction are standby；
(2), Ligusticum wallichii is ground into coarse powder, crosses 24 mesh sieves, adds 10 times of 70% ethanol of amount and soaks 2 hours, is heated to reflux 3 times,
Each extraction time be 3 hours, the 2nd time and the ethanol consumption of number be 8 times of medicinal material weight later, filters, merging filtrate, filters
It is 1.15~1.25 that liquid, which is concentrated into the relative density under the conditions of 50~70 DEG C, adds ethanol to make alcohol content be 60%, stands 48 hours,
Make precipitation, merge, reclaim ethanol, be condensed into thick paste, it is 1-5 that concentrate, which adds water to the ratio between every gram of every milliliter of volume and medicinal material amount:
5-1, filtering, filtrate crosses large pore resin absorption column, is first eluted with water to the reaction of sugar and is negative, then with 35% ethanol elution, receives
Collect eluent, reclaim ethanol, concentrate, filtration, it is standby to obtain extract, collects the dregs of a decoction, standby；
(3), take the dregs of a decoction of (1) and (2) to add the water of 15 times of amounts, extract 3 times, 3 hours every time, close under the conditions of 50~60 DEG C
And extract solution, filtering, merging filtrate, the medicinal extract that relative density is 1.10~1.25 is concentrated into, it is standby；
(4), Longstamen Onion Bulb crushes, and crosses 24 mesh sieves, and adding 70% ethanol makes alcohol content be 50%, places 48 hours, makes precipitation, mistake
Filter, supernatant is taken, reclaim ethanol, and it is 1.10~1.20 to be concentrated into relative density under the conditions of 60~70 DEG C, is concentrated into thick paste；
(5), merge extract, the medicinal extract of (3) and the thick paste of (4) of (2), be well mixed, dry, pulverize, add
(1) volatile oil and borneol, mix, add in the polyethylene glycol M6000 of molten condition, stir, it is uniformly dispersed, insulation is standby
With；By well mixed melting matrix as in attemperator pill dripping machine and keeping matrix to be instiled in stirring, start, liquid is used
Body paraffin or silicone oil do the cooling agent of dripping pill shaping.Manufactured dripping pill is taken out from cooling agent, carried out with a small amount of absolute ethyl alcohol
The forced air drying under the conditions of 30~40 DEG C in the disk of stand is placed in after Rapid Cleaning, picks ball, glazing, packaging.Produce pill 1000.
Embodiment 2：The preparation technology of vital energy regualting and blood circulation-promoting dripping pill
Prescription：Fructus cinnamomi camphorae 350g, Longstamen Onion Bulb 25g, Ligusticum wallichii 250g, borneol 4g；
(1), rice is withered is ground into coarse powder, crosses 24 mesh sieves, adds 8 times of amount 75% ethanol immersions, and soak time is：7 hours, surpass
Sound wave extracts 80 minutes, filters, and collects filtrate, and vapor steams the solvent in filtrate, obtains Cinnamoman Migao H.W.Li, and the dregs of a decoction are standby；
(2), Ligusticum wallichii is ground into coarse powder, crosses 24 mesh sieves, adds 10 times of 70% ethanol of amount and soaks 2 hours, is heated to reflux 3 times,
Each extraction time be 3 hours, the 2nd time and the ethanol consumption of number be 8 times of medicinal material weight later, filters, merging filtrate, filters
It is 1.15~1.25 that liquid, which is concentrated into the relative density under the conditions of 50~70 DEG C, adds ethanol to make alcohol content be 60%, stands 48 hours,
Make precipitation, merge, reclaim ethanol, be condensed into thick paste, it is 1-5 that concentrate, which adds water to the ratio between every gram of every milliliter of volume and medicinal material amount:
5-1, filtering, filtrate crosses large pore resin absorption column, is first eluted with water to the reaction of sugar and is negative, then with 35% ethanol elution, receives
Collect eluent, reclaim ethanol, concentrate, filtration, it is standby to obtain extract, collects the dregs of a decoction, standby；
(3), take the dregs of a decoction of (1) and (2) to add the water of 15 times of amounts, extract 3 times, 3 hours every time, close under the conditions of 50~60 DEG C
And extract solution, filtering, merging filtrate, the medicinal extract that relative density is 1.10~1.25 is concentrated into, it is standby；
(4), Longstamen Onion Bulb crushes, and crosses 24 mesh sieves, and adding 70% ethanol makes alcohol content be 50%, places 48 hours, makes precipitation, mistake
Filter, supernatant is taken, reclaim ethanol, and it is 1.10~1.20 to be concentrated into relative density under the conditions of 60~70 DEG C, is concentrated into thick paste；
(5), merge extract, the medicinal extract of (3) and the thick paste of (4) of (2), be well mixed, dry, pulverize, add
(1) volatile oil and borneol, mix, add in the polyethylene glycol M6000 of molten condition, stir, it is uniformly dispersed, insulation is standby
With；By well mixed melting matrix as in attemperator pill dripping machine and keeping matrix to be instiled in stirring, start, liquid is used
Body paraffin or silicone oil do the cooling agent of dripping pill shaping.Manufactured dripping pill is taken out from cooling agent, carried out with a small amount of absolute ethyl alcohol
The forced air drying under the conditions of 30~40 DEG C in the disk of stand is placed in after Rapid Cleaning, picks ball, glazing, packaging.Produce pill 1000.
Embodiment 3：The preparation technology of vital energy regualting and blood circulation-promoting dripping pill
Prescription：Fructus cinnamomi camphorae 400g, Longstamen Onion Bulb 30g, Ligusticum wallichii 300g, borneol 8g；
(1), rice is withered is ground into coarse powder, crosses 24 mesh sieves, adds 8 times of amount 75% ethanol immersions, and soak time is：7 hours, surpass
Sound wave extracts 80 minutes, filters, and collects filtrate, and vapor steams the solvent in filtrate, obtains Cinnamoman Migao H.W.Li, and the dregs of a decoction are standby；
(2), Ligusticum wallichii is ground into coarse powder, crosses 24 mesh sieves, adds 10 times of 70% ethanol of amount and soaks 2 hours, is heated to reflux 3 times,
Each extraction time be 3 hours, the 2nd time and the ethanol consumption of number be 8 times of medicinal material weight later, filters, merging filtrate, filters
It is 1.15~1.25 that liquid, which is concentrated into the relative density under the conditions of 50~70 DEG C, adds ethanol to make alcohol content be 60%, stands 48 hours,
Make precipitation, merge, reclaim ethanol, be condensed into thick paste, it is 1-5 that concentrate, which adds water to the ratio between every gram of every milliliter of volume and medicinal material amount:
5-1, filtering, filtrate crosses large pore resin absorption column, is first eluted with water to the reaction of sugar and is negative, then with 35% ethanol elution, receives
Collect eluent, reclaim ethanol, concentrate, filtration, it is standby to obtain extract, collects the dregs of a decoction, standby；
(3), take the dregs of a decoction of (1) and (2) to add the water of 15 times of amounts, extract 3 times, 3 hours every time, close under the conditions of 50~60 DEG C
And extract solution, filtering, merging filtrate, the medicinal extract that relative density is 1.10~1.25 is concentrated into, it is standby；
(4), Longstamen Onion Bulb crushes, and crosses 24 mesh sieves, and adding 70% ethanol makes alcohol content be 50%, places 48 hours, makes precipitation, mistake
Filter, supernatant is taken, reclaim ethanol, and it is 1.10~1.20 to be concentrated into relative density under the conditions of 60~70 DEG C, is concentrated into thick paste；
(5), merge extract, the medicinal extract of (3) and the thick paste of (4) of (2), be well mixed, dry, pulverize, add
(1) volatile oil and borneol, mix, add in the polyethylene glycol M6000 of molten condition, stir, it is uniformly dispersed, insulation is standby
With；By well mixed melting matrix as in attemperator pill dripping machine and keeping matrix to be instiled in stirring, start, liquid is used
Body paraffin or silicone oil do the cooling agent of dripping pill shaping.Manufactured dripping pill is taken out from cooling agent, carried out with a small amount of absolute ethyl alcohol
The forced air drying under the conditions of 30~40 DEG C in the disk of stand is placed in after Rapid Cleaning, picks ball, glazing, packaging.Produce pill 1000.
Embodiment 4：The preparation technology of vital energy regualting and blood circulation-promoting dripping pill
Prescription：Fructus cinnamomi camphorae 450g, Longstamen Onion Bulb 36g, Ligusticum wallichii 360g, borneol 9g；
(1), rice is withered is ground into coarse powder, crosses 24 mesh sieves, adds 8 times of amount 75% ethanol immersions, and soak time is：7 hours, surpass
Sound wave extracts 80 minutes, filters, and collects filtrate, and vapor steams the solvent in filtrate, obtains Cinnamoman Migao H.W.Li, and the dregs of a decoction are standby；
(2), Ligusticum wallichii is ground into coarse powder, crosses 24 mesh sieves, adds 10 times of 70% ethanol of amount and soaks 2 hours, is heated to reflux 3 times,
Each extraction time be 3 hours, the 2nd time and the ethanol consumption of number be 8 times of medicinal material weight later, filters, merging filtrate, filters
It is 1.15~1.25 that liquid, which is concentrated into the relative density under the conditions of 50~70 DEG C, adds ethanol to make alcohol content be 60%, stands 48 hours,
Make precipitation, merge, reclaim ethanol, be condensed into thick paste, it is 1-5 that concentrate, which adds water to the ratio between every gram of every milliliter of volume and medicinal material amount:
5-1, filtering, filtrate crosses large pore resin absorption column, is first eluted with water to the reaction of sugar and is negative, then with 35% ethanol elution, receives
Collect eluent, reclaim ethanol, concentrate, filtration, it is standby to obtain extract, collects the dregs of a decoction, standby；
(3), take the dregs of a decoction of (1) and (2) to add the water of 15 times of amounts, extract 3 times, 3 hours every time, close under the conditions of 50~60 DEG C
And extract solution, filtering, merging filtrate, the medicinal extract that relative density is 1.10~1.25 is concentrated into, it is standby；
(4), Longstamen Onion Bulb crushes, and crosses 24 mesh sieves, and adding 70% ethanol makes alcohol content be 50%, places 48 hours, makes precipitation, mistake
Filter, supernatant is taken, reclaim ethanol, and it is 1.10~1.20 to be concentrated into relative density under the conditions of 60~70 DEG C, is concentrated into thick paste；
(5), merge extract, the medicinal extract of (3) and the thick paste of (4) of (2), be well mixed, dry, pulverize, add
(1) volatile oil and borneol, mix, add in the polyethylene glycol M6000 of molten condition, stir, it is uniformly dispersed, insulation is standby
With；By well mixed melting matrix as in attemperator pill dripping machine and keeping matrix to be instiled in stirring, start, liquid is used
Body paraffin or silicone oil do the cooling agent of dripping pill shaping.Manufactured dripping pill is taken out from cooling agent, carried out with a small amount of absolute ethyl alcohol
The forced air drying under the conditions of 30~40 DEG C in the disk of stand is placed in after Rapid Cleaning, picks ball, glazing, packaging.Produce pill 1000.
Embodiment 5：The preparation technology of vital energy regualting and blood circulation-promoting dripping pill
Prescription：Fructus cinnamomi camphorae 500g, Longstamen Onion Bulb 40g, Ligusticum wallichii 400g, borneol 11g；
(1), rice is withered is ground into coarse powder, crosses 24 mesh sieves, adds 8 times of amount 75% ethanol immersions, and soak time is：7 hours, surpass
Sound wave extracts 80 minutes, filters, and collects filtrate, and vapor steams the solvent in filtrate, obtains Cinnamoman Migao H.W.Li, and the dregs of a decoction are standby；
(2), Ligusticum wallichii is ground into coarse powder, crosses 24 mesh sieves, adds 10 times of 70% ethanol of amount and soaks 2 hours, is heated to reflux 3 times,
Each extraction time be 3 hours, the 2nd time and the ethanol consumption of number be 8 times of medicinal material weight later, filters, merging filtrate, filters
It is 1.15~1.25 that liquid, which is concentrated into the relative density under the conditions of 50~70 DEG C, adds ethanol to make alcohol content be 60%, stands 48 hours,
Make precipitation, merge, reclaim ethanol, be condensed into thick paste, it is 1-5 that concentrate, which adds water to the ratio between every gram of every milliliter of volume and medicinal material amount:
5-1, filtering, filtrate crosses large pore resin absorption column, is first eluted with water to the reaction of sugar and is negative, then with 35% ethanol elution, receives
Collect eluent, reclaim ethanol, concentrate, filtration, it is standby to obtain extract, collects the dregs of a decoction, standby；
(3), take the dregs of a decoction of (1) and (2) to add the water of 15 times of amounts, extract 3 times, 3 hours every time, close under the conditions of 50~60 DEG C
And extract solution, filtering, merging filtrate, the medicinal extract that relative density is 1.10~1.25 is concentrated into, it is standby；
(4), Longstamen Onion Bulb crushes, and crosses 24 mesh sieves, and adding 70% ethanol makes alcohol content be 50%, places 48 hours, makes precipitation, mistake
Filter, supernatant is taken, reclaim ethanol, and it is 1.10~1.20 to be concentrated into relative density under the conditions of 60~70 DEG C, is concentrated into thick paste；
(5), merge extract, the medicinal extract of (3) and the thick paste of (4) of (2), be well mixed, dry, pulverize, add
(1) volatile oil and borneol, mix, add in the polyethylene glycol M6000 of molten condition, stir, it is uniformly dispersed, insulation is standby
With；By well mixed melting matrix as in attemperator pill dripping machine and keeping matrix to be instiled in stirring, start, liquid is used
Body paraffin or silicone oil do the cooling agent of dripping pill shaping.Manufactured dripping pill is taken out from cooling agent, carried out with a small amount of absolute ethyl alcohol
The forced air drying under the conditions of 30~40 DEG C in the disk of stand is placed in after Rapid Cleaning, picks ball, glazing, packaging.Produce pill 1000.
Embodiment 6：The preparation technology of vital energy regualting and blood circulation-promoting dripping pill
Prescription：Fructus cinnamomi camphorae 600g, Longstamen Onion Bulb 50g, Ligusticum wallichii 500g, borneol 15g；
(1), rice is withered is ground into coarse powder, crosses 24 mesh sieves, adds 8 times of amount 75% ethanol immersions, and soak time is：7 hours, surpass
Sound wave extracts 80 minutes, filters, and collects filtrate, and vapor steams the solvent in filtrate, obtains Cinnamoman Migao H.W.Li, and the dregs of a decoction are standby；
(2), Ligusticum wallichii is ground into coarse powder, crosses 24 mesh sieves, adds 10 times of 70% ethanol of amount and soaks 2 hours, is heated to reflux 3 times,
Each extraction time be 3 hours, the 2nd time and the ethanol consumption of number be 8 times of medicinal material weight later, filters, merging filtrate, filters
It is 1.15~1.25 that liquid, which is concentrated into the relative density under the conditions of 50~70 DEG C, adds ethanol to make alcohol content be 60%, stands 48 hours,
Make precipitation, merge, reclaim ethanol, be condensed into thick paste, it is 1-5 that concentrate, which adds water to the ratio between every gram of every milliliter of volume and medicinal material amount:
5-1, filtering, filtrate crosses large pore resin absorption column, is first eluted with water to the reaction of sugar and is negative, then with 35% ethanol elution, receives
Collect eluent, reclaim ethanol, concentrate, filtration, it is standby to obtain extract, collects the dregs of a decoction, standby；
(3), take the dregs of a decoction of (1) and (2) to add the water of 15 times of amounts, extract 3 times, 3 hours every time, close under the conditions of 50~60 DEG C
And extract solution, filtering, merging filtrate, the medicinal extract that relative density is 1.10~1.25 is concentrated into, it is standby；
(4), Longstamen Onion Bulb crushes, and crosses 24 mesh sieves, and adding 70% ethanol makes alcohol content be 50%, places 48 hours, makes precipitation, mistake
Filter, supernatant is taken, reclaim ethanol, and it is 1.10~1.20 to be concentrated into relative density under the conditions of 60~70 DEG C, is concentrated into thick paste；
(5), merge extract, the medicinal extract of (3) and the thick paste of (4) of (2), be well mixed, dry, pulverize, add
(1) volatile oil and borneol, mix, add in the polyethylene glycol M6000 of molten condition, stir, it is uniformly dispersed, insulation is standby
With；By well mixed melting matrix as in attemperator pill dripping machine and keeping matrix to be instiled in stirring, start, liquid is used
Body paraffin or silicone oil do the cooling agent of dripping pill shaping.Manufactured dripping pill is taken out from cooling agent, carried out with a small amount of absolute ethyl alcohol
The forced air drying under the conditions of 30~40 DEG C in the disk of stand is placed in after Rapid Cleaning, picks ball, glazing, packaging.Produce pill 1000.
Embodiment 7：The preparation technology (high component) of vital energy regualting and blood circulation-promoting dripping pill
Prescription：Fructus cinnamomi camphorae 650g, Longstamen Onion Bulb 55g, Ligusticum wallichii 550g, borneol 16g；
(1), rice is withered is ground into coarse powder, crosses 24 mesh sieves, adds 8 times of amount 75% ethanol immersions, and soak time is：7 hours, surpass
Sound wave extracts 80 minutes, filters, and collects filtrate, and vapor steams the solvent in filtrate, obtains Cinnamoman Migao H.W.Li, and the dregs of a decoction are standby；
(2), Ligusticum wallichii is ground into coarse powder, crosses 24 mesh sieves, adds 10 times of 70% ethanol of amount and soaks 2 hours, is heated to reflux 3 times,
Each extraction time be 3 hours, the 2nd time and the ethanol consumption of number be 8 times of medicinal material weight later, filters, merging filtrate, filters
It is 1.15~1.25 that liquid, which is concentrated into the relative density under the conditions of 50~70 DEG C, adds ethanol to make alcohol content be 60%, stands 48 hours,
Make precipitation, merge, reclaim ethanol, be condensed into thick paste, it is 1-5 that concentrate, which adds water to the ratio between every gram of every milliliter of volume and medicinal material amount:
5-1, filtering, filtrate crosses large pore resin absorption column, is first eluted with water to the reaction of sugar and is negative, then with 35% ethanol elution, receives
Collect eluent, reclaim ethanol, concentrate, filtration, it is standby to obtain extract, collects the dregs of a decoction, standby；
(3), take the dregs of a decoction of (1) and (2) to add the water of 15 times of amounts, extract 3 times, 3 hours every time, close under the conditions of 50~60 DEG C
And extract solution, filtering, merging filtrate, the medicinal extract that relative density is 1.10~1.25 is concentrated into, it is standby；
(4), Longstamen Onion Bulb crushes, and crosses 24 mesh sieves, and adding 70% ethanol makes alcohol content be 50%, places 48 hours, makes precipitation, mistake
Filter, supernatant is taken, reclaim ethanol, and it is 1.10~1.20 to be concentrated into relative density under the conditions of 60~70 DEG C, is concentrated into thick paste；
(5), merge extract, the medicinal extract of (3) and the thick paste of (4) of (2), be well mixed, dry, pulverize, add
(1) volatile oil and borneol, mix, add in the polyethylene glycol M6000 of molten condition, stir, it is uniformly dispersed, insulation is standby
With；By well mixed melting matrix as in attemperator pill dripping machine and keeping matrix to be instiled in stirring, start, liquid is used
Body paraffin or silicone oil do the cooling agent of dripping pill shaping.Manufactured dripping pill is taken out from cooling agent, carried out with a small amount of absolute ethyl alcohol
The forced air drying under the conditions of 30~40 DEG C in the disk of stand is placed in after Rapid Cleaning, picks ball, glazing, packaging.Produce pill 1000.
Claims (8)
1. a kind of vital energy regualting and blood circulation-promoting preparation is preparing the application in treating or preventing renal damage medicine.
2. a kind of vital energy regualting and blood circulation-promoting preparation according to claim 1 is preparing the application in treating or preventing renal damage medicine,
It is characterized in that：Vital energy regualting and blood circulation-promoting preparation is preparing treatment or prevention Chronic Kidney Disease, acute renal injury, drug-induced renal impairment medicine
In application.
3. according to a kind of any described vital energy regualting and blood circulation-promoting preparations of claim 1-2 in treatment or prevention renal damage medicine is prepared
Using, it is characterised in that：The vital energy regualting and blood circulation-promoting preparation is by the Fructus cinnamomi camphorae of 350-600 parts by weight, the Longstamen Onion Bulb of 25-50 parts by weight,
The Ligusticum wallichii of 250-500 parts by weight, the borneol extraction of 4-15 parts by weight are prepared.
4. a kind of vital energy regualting and blood circulation-promoting preparation according to claim 3 is preparing the application in treating or preventing renal damage medicine,
It is characterized in that：The vital energy regualting and blood circulation-promoting preparation is by the Fructus cinnamomi camphorae of 400-500 parts by weight, the Longstamen Onion Bulb of 30-40 parts by weight, 300-
The Ligusticum wallichii of 400 parts by weight, the borneol extraction of 8-11 parts by weight are prepared.
5. a kind of vital energy regualting and blood circulation-promoting preparation according to claim 4 is preparing the application in treating or preventing renal damage medicine,
It is characterized in that：The vital energy regualting and blood circulation-promoting preparation is by the Fructus cinnamomi camphorae of 450 parts by weight, the Longstamen Onion Bulb of 36 parts by weight, the river of 360 parts by weight
Rhizome of chuanxiong, the borneol extraction of 9 parts by weight are prepared.
6. according to a kind of any described vital energy regualting and blood circulation-promoting preparations of claim 1-2 in treatment or prevention renal damage medicine is prepared
Using, it is characterised in that：Described vital energy regualting and blood circulation-promoting preparation is tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard
It is capsule, soft capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, paste, sublimed preparation, supensoid agent, pulvis, molten
Liquor, injection, suppository, spray, pill, patch.
7. a kind of vital energy regualting and blood circulation-promoting preparation according to right 6 is preparing the application in treating or preventing renal damage medicine, it is special
Sign is：Described vital energy regualting and blood circulation-promoting preparation is pill.
8. according to a kind of any described vital energy regualting and blood circulation-promoting preparations of right 1-2 answering in treatment or prevention renal damage medicine is prepared
With, it is characterised in that：Described vital energy regualting and blood circulation-promoting preparation containing conventional excipient, such as adhesive, filler, tablet agent,
Diluent, wetting agent, disintegrant, colouring agent, flavor enhancement, wetting agent and medicinal carrier material.
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| CN114073740A (en) * | 2020-08-12 | 2022-02-22 | 贵州益佰制药股份有限公司 | Preparation method of dripping pills for regulating qi and activating blood circulation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114073740A (en) * | 2020-08-12 | 2022-02-22 | 贵州益佰制药股份有限公司 | Preparation method of dripping pills for regulating qi and activating blood circulation |
| CN114073740B (en) * | 2020-08-12 | 2022-11-15 | 贵州益佰制药股份有限公司 | Preparation method of dripping pills for regulating qi and activating blood circulation |
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