CN107519377A - A kind of inhibiting bacteria and diminishing inflammation composition and preparation method thereof and oral health care product - Google Patents
A kind of inhibiting bacteria and diminishing inflammation composition and preparation method thereof and oral health care product Download PDFInfo
- Publication number
- CN107519377A CN107519377A CN201710772076.XA CN201710772076A CN107519377A CN 107519377 A CN107519377 A CN 107519377A CN 201710772076 A CN201710772076 A CN 201710772076A CN 107519377 A CN107519377 A CN 107519377A
- Authority
- CN
- China
- Prior art keywords
- parts
- diminishing inflammation
- inhibiting bacteria
- raw material
- jasmine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Insects & Arthropods (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to oral health care technical field, the healthcare products of more particularly to a kind of inhibiting bacteria and diminishing inflammation composition and preparation method thereof and regulation microenvironment.In parts by weight, the inhibiting bacteria and diminishing inflammation composition is made up of the following raw material：3~10 parts of spider freeze-drying powder, 10~20 parts of honeysuckle, 8~12 parts of the coptis, 25~35 parts of gypsum, 10~14 parts of the wind-weed, 4~8 parts of asarum, 10~20 parts of the dried rhizome of rehmannia, 10~14 parts of the root bark of tree peony, 10~20 parts of Chinese herbaceous peony, 10~14 parts of radix scrophulariae, 8~12 parts of holy basil, 3~7 parts of Jasmine.Inhibiting bacteria and diminishing inflammation composition of the present invention can effectively suppress the growth of bacterium；Oral health care product of the present invention can play the effect such as anti-inflammatory, antibacterial, analgesia, hemostasis, fresh breath, to alleviating people oral cavity malaise symptoms, keeping the good Tiny ecosystem in oral cavity to have significant curative effect.
Description
Technical field
The present invention relates to oral health care technical field, more particularly to a kind of inhibiting bacteria and diminishing inflammation composition and preparation method thereof
With oral health care product.
Background technology
With the continuous improvement of living standards of the people quality, the rhythm of life of people is more and more faster, work dinner party or kith and kin
Good friend's party turns into extremely usual thing, and oral peculiar smell perplexs into one in human communication is big.Do not focus on for a long time
The people of oral cleaning, contained food residual easily grows the growth of streptococcus mutans in oral cavity in oral cavity, and food residual is easy
Harmful dental plaque acid is fermented into, eventually causes carious tooth.With carious tooth, gingivitis, periodontitis, portacaval mucositis and decayed tooth, tooth
The people of the mouth diseases such as all diseases, easy breed bacteria, especially anaerobic bacteria in its oral cavity, its decomposition have produced sulfide, send out
Go out the taste of corruption, and produce halitosis.
Gingivitis, bleeding, swelling and aching of gum are typical periodontal disease symptoms, and China has 97 percent according to statistics
There is periodontal disease in crowd, periodontal disease is one of the main reason for crowd lost tooth in more than 35 years old.Gingivitis is normal
The periodontal tissue disease seen, it is due to not pay attention to oral hygiene, tooth is formed by the thing such as swill, bacterium around tooth
Long-time stimulus caused by soft tartar and the dental calculus of hard, and the reason such as incorrect tooth-brushing habit, hypovitaminosis institute
Cause.Improve oral healthy condition has turned into that China's oral hygiene one is important and difficult task.Therefore, there is anti-inflammatory
Effect, the oral health care product that can effectively remove halitosis become hot-sale products.
Mouthwash is the oral-cavity article of people's daily life cleaning and health care, be mainly used in keeping oral cavity and cleaning of teeth,
Promote breath freshening, nurse gum, safeguard good microenvironment in oral cavity etc..The species of mouthwash mainly includes gargling for fluoride
Water, anti-tooth mycoderm mouthwash, suppress tooth mycoderm mouthwash, anti-sensitive mouthwash, Chinese herbal medicine class mouthwash etc..Contain Chinese herbal medicine at present
The mouthwash of composition is particularly subject to the favor of consumer.The patent of the mouthwash containing medicinal herb componentses also compares more, such as disclosure/bulletin
Number CN104688850A invention provides a kind of Chinese medicine mouth wash, and raw material consists predominantly of radix scutellariae, honeysuckle, the coptis, the capsule of weeping forsythia, wood
Sugar alcohol, 95% ethanol, the ratio of selected raw material use radix scutellariae：Honeysuckle：The coptis：The capsule of weeping forsythia：Xylitol is 1：1：0.8：0.8：1,
Four kinds of selected Chinese medicines of extraction, obtain the extract solution of radix scutellariae, honeysuckle, the coptis, the capsule of weeping forsythia, and sterilization treatment, root are carried out to extract solution
Xylitol is added according to ratio to be allocated, and is finally made mouthwash./ notification number CN104083662A disclosure of the invention is and for example disclosed
A kind of mouthwash and preparation method for eliminating stomatitis type halitosis, takes the primary raw material of following weight proportions to be prepared：Bamboo
10~15 parts of salt, sweet clover 6-12 parts, honeysuckle 15-20 parts, 4~10 parts of lophatherum gracile, 5~15 parts of radix glycyrrhizae, 2~9 parts of the coptis are thin
15~25 parts of lotus, 5~10 parts of the dried rhizome of rehmannia.These patented products have been imitated to fresh breath, nursing gum, improvement oral environment etc.
Fruit, but in antibacterial, anti-inflammatory, analgesia, detumescence hemostasis etc. less effective.Therefore, develop a with inhibiting bacteria and diminishing inflammation, analgesia
Stop blooding and prevent to alleviate the herbal mixture oral health care product of all kinds of oral inflammations, for alleviating people oral cavity uncomfortable diseases
Shape, keep the good Tiny ecosystem in oral cavity, slow down human communication pressure etc., it is significant.
The content of the invention
In view of this, the invention provides a kind of inhibiting bacteria and diminishing inflammation composition and preparation method thereof and oral health nursing production
Product.The inhibiting bacteria and diminishing inflammation composition can effectively suppress the growth of bacterium, and can play anti-inflammatory, analgesia, anastalsis, to alleviating people
Oral cavity malaise symptoms, keep the good Tiny ecosystem in oral cavity there is significant curative effect.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The invention provides a kind of inhibiting bacteria and diminishing inflammation composition, in parts by weight, it is made up of the following raw material：
3~10 parts of spider freeze-drying powder, 10~20 parts of honeysuckle, 8~12 parts of the coptis, 25~35 parts of gypsum, the wind-weed 10~14
Part, 4~8 parts of asarum, 10~20 parts of the dried rhizome of rehmannia, 10~14 parts of the root bark of tree peony, 10~20 parts of Chinese herbaceous peony, 10~14 parts of radix scrophulariae, holy basil 8~12
Part, 3~7 parts of Jasmine.
Preferably, in parts by weight, it is made up of the following raw material：
7 parts of spider freeze-drying powder, 15 parts of honeysuckle, 10 parts of the coptis, 30 parts of gypsum, 12 parts of the wind-weed, 6 parts of asarum, 15 parts of the dried rhizome of rehmannia,
12 parts of the root bark of tree peony, 15 parts of Chinese herbaceous peony, 12 parts of radix scrophulariae, 10 parts of holy basil, 5 parts of Jasmine.
In an embodiment provided by the invention, in parts by weight, it is made up of the following raw material：
3 parts of spider freeze-drying powder, 10 parts of honeysuckle, 12 parts of the coptis, 25 parts of gypsum, 14 parts of the wind-weed, 4 parts of asarum, 20 parts of the dried rhizome of rehmannia,
10 parts of the root bark of tree peony, 20 parts of Chinese herbaceous peony, 10 parts of radix scrophulariae, 12 parts of holy basil, 3 parts of Jasmine.
In another embodiment provided by the invention, in parts by weight, it is made up of the following raw material：
10 parts of spider freeze-drying powder, 20 parts of honeysuckle, 8 parts of the coptis, 35 parts of gypsum, 10 parts of the wind-weed, 8 parts of asarum, 10 parts of the dried rhizome of rehmannia,
14 parts of the root bark of tree peony, 10 parts of Chinese herbaceous peony, 14 parts of radix scrophulariae, 8 parts of holy basil, 7 parts of Jasmine.
Present invention also offers the preparation method of the inhibiting bacteria and diminishing inflammation composition, by raw material spider freeze-drying powder, honeysuckle, Huang
Company, gypsum, the wind-weed, asarum, the dried rhizome of rehmannia, the root bark of tree peony, Chinese herbaceous peony, radix scrophulariae, holy basil, Jasmine mixing, alcohol extracting, filtering, obtain antibacterial disappear
Scorching composition.
In embodiment provided by the invention, alcohol extracting is：It is soaked in ethanol water 10~20 days.
In a specific embodiment provided by the invention, the time of alcohol extracting is 15 or 20 days.
Preferably, the volumn concentration of ethanol is 50%~70% in ethanol water.
In an embodiment provided by the invention, the volumn concentration of ethanol is 55% or 60% in ethanol water.
Preferably, in terms of g/mL, the amount ratio of raw material and ethanol water is (100~200)：1000.
Preferably, in terms of g/mL, the amount ratio of raw material and ethanol water is (140~150)：1000.
Present invention also offers a kind of oral health care product, includes inhibiting bacteria and diminishing inflammation composition of the invention, and medicine
Acceptable auxiliary material in or bromatology.
Preferably, the formulation of oral health care product be oral cleansing lotion, chewing gum, toothpaste, tooth gel, tooth powder,
Mouthwash or tablet.
In an embodiment provided by the invention, the formula of oral health care product is：7 parts of spider freeze-drying powder, gold and silver
Spend 15 parts, 10 parts of the coptis, 30 parts of gypsum, 12 parts of the wind-weed, 6 parts of asarum, 15 parts of the dried rhizome of rehmannia, 12 parts of the root bark of tree peony, 15 parts of Chinese herbaceous peony, radix scrophulariae 12
Part, 10 parts of holy basil, 5 parts of Jasmine, 70%vol ethanol 1000mL.
The invention provides a kind of inhibiting bacteria and diminishing inflammation composition and preparation method thereof and oral health care product.With parts by weight
Meter, the inhibiting bacteria and diminishing inflammation composition are made up of the following raw material：3~10 parts of spider freeze-drying powder, 10~20 parts of honeysuckle, the coptis 8~12
Part, 25~35 parts of gypsum, 10~14 parts of the wind-weed, 4~8 parts of asarum, 10~20 parts of the dried rhizome of rehmannia, 10~14 parts of the root bark of tree peony, Chinese herbaceous peony 10~20
Part, 10~14 parts of radix scrophulariae, 8~12 parts of holy basil, 3~7 parts of Jasmine.The technique effect that the present invention has is：
1st, inhibiting bacteria and diminishing inflammation composition of the present invention can effectively suppress the growth of bacterium；
2nd, oral health care product of the present invention can play a part of anti-inflammatory, antibacterial, analgesia, hemostasis, to alleviating people's mouth
Chamber malaise symptoms, keep the good Tiny ecosystem in oral cavity that there is significant curative effect.
3rd, inhibiting bacteria and diminishing inflammation composition and oral health care product of the present invention are prepared simple, are adapted to industrialized production.
Embodiment
The invention discloses a kind of inhibiting bacteria and diminishing inflammation composition and preparation method thereof and oral health care product, this area skill
Art personnel can use for reference present disclosure, be suitably modified technological parameter realization.In particular, all similar replacements and
Change apparent to those skilled in the art, they are considered as being included in the present invention.The present invention method and
Using being described by preferred embodiment, related personnel can substantially not depart from present invention, spirit and scope
It is interior that method described herein and application are modified or suitably changed with combining, to realize and using the technology of the present invention.
In embodiments of the present invention, the preparation method of spider freeze-drying powder is：1st, take and freezed more than 48 hours at -80 DEG C
Spider is placed in rustless steel cylinder and smashed to pieces；2nd, the spider after smashing to pieces is inverted into pulverizer, Freezing smashing about 30 seconds；3rd, spider powder
Through the freeze-drying of 48 hours, then it is vacuum-packed；4th, freezer of the spider freeze-drying powder that vacuum packet installs at -18 DEG C is stored up
Deposit.
In the present invention, it is the effect of ingredients in prescription：
Spider freeze-drying powder：It is cold in nature, bitter, ceases wind antispastic, subdhing swelling and detoxicating, dispelling wind and eliminating dampness, remove obstruction in channels to relieve pain.
Honeysuckle：It is cold in nature, it is sweet, there is the effect of clearing heat and detoxicating, anti-inflammatory, qi-restoratives treat wind；
The coptis：Heat-clearing and damp-drying drug, purging intense heat and detonicating；
Gypsum：Sweet, pungent, Great Cold , Cheongju hot purging intense heat, relieving restlessness is quenched the thirst.For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, dyspnea and cough due to lung-heat, stomach fire
High Sheng, have a headache, toothache；
The wind-weed：Function with clearing heat-fire, fluid dryness；
Asarum：With expelling wind and clearing away cold, sensible analgesic, the effect of Wenfei of drink；
The dried rhizome of rehmannia：With clearing heat and cooling blood effect；
The root bark of tree peony：With clearing heat and cooling blood, activate blood circulation and disperse blood clots, reducing the asthenic fever and other effects；
Chinese herbaceous peony：With antispastic, ease pain, the effect of stimulating the menstrual flow；
Radix scrophulariae：Antibacterial；
Holy basil：Fragrance；
Jasmine：Acted on pungent, sweet, cool, clearing heat and detoxicating, dampness removing.
In inhibiting bacteria and diminishing inflammation composition provided by the invention and preparation method thereof and oral health care product it is raw materials used or
Auxiliary material can be bought by market.
With reference to embodiment, the present invention is expanded on further：
Embodiment 1
The raw material and dosage of the present embodiment Chinese medicine composition are as follows：
Spider freeze-drying powder 7g, honeysuckle 15g, coptis 10g, gypsum 30g, wind-weed 12g, asarum 6g, dried rhizome of rehmannia 15g, the root bark of tree peony
12g, Chinese herbaceous peony 15g, radix scrophulariae 12g, holy basil 10g, Jasmine 5g.
Preparation method is：
Raw material is standby in 55% edible ethanol soak at room temperature of 1000mL 15 days, filtering.
Embodiment 2
The raw material and dosage of the present embodiment Chinese medicine composition are as follows：
Spider freeze-drying powder 3g, honeysuckle 10g, coptis 12g, gypsum 25g, wind-weed 14g, asarum 4g, dried rhizome of rehmannia 20g, the root bark of tree peony
10g, Chinese herbaceous peony 20g, radix scrophulariae 10g, holy basil 12g, Jasmine 3g.
Preparation method is：
Raw material is standby in 60% edible ethanol soak at room temperature of 1000mL 20 days, filtering.
Embodiment 3
The raw material and dosage of the present embodiment Chinese medicine composition are as follows：
Spider freeze-drying powder 10g, honeysuckle 20g, coptis 8g, gypsum 35g, wind-weed 10g, asarum 8g, dried rhizome of rehmannia 10g, the root bark of tree peony
14g, Chinese herbaceous peony 10g, radix scrophulariae 14g, holy basil 8g, Jasmine 7g.
Preparation method is：
Raw material is standby in 55% edible ethanol soak at room temperature of 1000mL 15 days, filtering.
Comparative example 1
The raw material and dosage of this comparative example Chinese medicine composition are following (compared with Example 1, lacking spider freeze-drying powder)：
Honeysuckle 15g, coptis 10g, gypsum 30g, wind-weed 12g, asarum 6g, dried rhizome of rehmannia 15g, root bark of tree peony 12g, Chinese herbaceous peony 15g, radix scrophulariae
12g, holy basil 10g, Jasmine 5g.
Preparation method is：
Raw material is standby in 55% edible ethanol soak at room temperature of 1000mL 15 days, filtering.
Comparative example 2
The raw material and dosage of this comparative example Chinese medicine composition are following (compared with Example 1, lacking honeysuckle and radix scrophulariae)：
Spider freeze-drying powder 7g, coptis 10g, gypsum 30g, wind-weed 12g, asarum 6g, dried rhizome of rehmannia 15g, root bark of tree peony 12g, Chinese herbaceous peony 15g,
Holy basil 10g, Jasmine 5g.
Preparation method is：
Raw material is standby in 55% edible ethanol soak at room temperature of 1000mL 15 days, filtering.
Comparative example 3
The raw material and dosage of this comparative example Chinese medicine composition (compared with Example 1, lack gypsum, Chinese herbaceous peony and zero mound as follows
It is fragrant)：
Spider freeze-drying powder 7g, honeysuckle 15g, coptis 10g, wind-weed 12g, asarum 6g, dried rhizome of rehmannia 15g, root bark of tree peony 12g, radix scrophulariae
12g, Jasmine 5g.
Preparation method is：
Raw material is standby in 55% edible ethanol soak at room temperature of 1000mL 15 days, filtering.
Comparative example 4
The raw material and preparation method of this comparative example Chinese medicine composition are implemented with reference to disclosure/notification number CN104083662A inventions
Example 5：
Raw material：12 parts of bamboo salt, 9 parts of sweet clover, 18 parts of honeysuckle, 6 parts of lophatherum gracile, 10 parts of radix glycyrrhizae, 5 parts of the coptis, peppermint 20
Part, 8 parts of the dried rhizome of rehmannia.
The mouthwash preparation process for eliminating stomatitis type halitosis is as follows：
(1) lophatherum gracile is dried into rear pulverization, crosses 100 mesh sieves, obtain bamboo leaf powder；
(2) peppermint is cleaned into mashing, with 80 DEG C of hot-water soaks, filtering, obtains filtrate；
(3) sweet clover, honeysuckle, cloves, radix glycyrrhizae and the coptis are well mixed, moistened 45 minutes with three-level pure mellow wine is vexed, it is stand-by；
(4) mixture obtained by step (3) is added in filtrate obtained by step (2), after intense fire is fried open, turns to be cooked by slow fire 50 points
Clock, bamboo leaf powder obtained by step (1) is added after truce, stand 35 minutes, take supernatant stand-by；
(5) bamboo salt is added in supernatant obtained by step (4), simmers 40 minutes, after being sufficiently stirred, produce.
The extracorporeal bacteria inhibitor test of test example 1
1st, experimental strain
Bacterium：Golden glucose coccus (ATCC 6538), lactobacillus Candida albicans (ATCC 10231) bacteria suspension.
2nd, strain inoculum density
Bacterium kind inoculum density is 50~200cfu/mL bacterium solutions.
The preparation of strain suspension：Diluted respectively with sterile saline and cultivated strain, 50~200cf'u/mL is made
Bacterium suspension.
3rd, the preparation of experiment antibacterial liquid
This experiment is as antibacterial liquid, antibacterial formula of liquid from embodiment 1-3, comparative example 1-4 Chinese herbal medicine extract
Traditional Chinese medicine extraction stoste.Wherein, Chinese herbal medicine extract is with crude drug gauge.
The oral health care product sample of bacteriostatic agent blank is made simultaneously.
4th, mouthwash sample inoculation
The oral health care product of specified quantity is inoculated in above two test organisms respectively in aseptic condition, mixed
Uniformly.Sample will be vaccinated with to preserve under the conditions of 20 DEG C, respectively in 5 minutes, 30 minutes, 1 hour, 12 hours detection samples
Clump count, to judge its bacteriostasis.
5th, experimental result and discussion
(1) evaluation criterion
Fungistatic effect is used as evaluation index using the percentage that clump count declines.The calculation of the index is as follows：
Percentage (%)=(A that clump count declines0-An)/A0× 100%
In formula：A0During to be initially added microorganism in mouthwash microorganism content；AnFor different detection time microorganisms
Content.
Bacterium declines 90% in total plate count in 30 minutes, if can maintain total number of bacteria in 12 hours, is judged as sample
Fungistatic effect it is good.
(2) result of the test
The mouthwash of table 1 suppresses the experimental result of golden glucose coccus
Note：0h result is clump count when being seeded initially.
The mouthwash of table 2 suppresses the experimental result of lactobacillus Candida albicans
Note：0h result is clump count when being seeded initially.
Result of the test shows, foundation《Disposable Sanitary Accessory sanitary standard》(GB15979-2002), oral health
Under test conditions, to golden glucose coccus, the bacteriostasis rate ＞ 90% of Candida albicans, product has relatively strong suppression to care product
Bacterium acts on.
2 antibacterial clinical effectiveness of test example is studied
1st, Clinical design
(1) using double blinding, the research method of own control, in lasting 4 weeks, participant uses the mouthwash of distribution,
As requested, gargle daily 3 times.
(2) samples selection
Aspiration experimenter is recruited, volunteer's preliminary screening work is carried out within 14 days before experiment, subject is included by inclusive criteria.
All facings of supersonic cleaning.After 14 days, volunteer is screened again, takes 30 GI=0 persons to include as formal subject.Ultrasonic wave
Formal all sound of baby talk faces of subject are removed in scaling.Plaque stain, show PLI=0.Recording mouth soft tissue and mouth healthy condition,
The same day starts to test.
(3) experimental procedure and detection content
The mouthwash comprising the active ingredient of embodiment 1 is test group in Selection experiment example 1, while sets 20%vol alcohol
Solution is as control group.
Every kind of 30 bottles of mouthwash is numbered, and is divided into two groups of A, B.Take out a kind of mouthwash from every group of bottle at random, every 2 kinds
Mouthwash composition is a, totally 30 parts, is respectively put into 30 cartons.By 30 subjects, it is affixed at random on carton.Subject's root
Arbitrarily taken in corresponding carton 1 bottle of mouthwash according to the numbering of oneself, start to test.During experiment, stop all mechanical cleanings
Measure, containing the corresponding mouthwash numberings of PLI are recorded after gargling 4d, reclaim mouthwash.Mouthwash surplus is checked, judges compliance,
Substantially poor person excludes experiment to compliance.Then recover daily cleaning measure, continue 10d, may be deposited with excluding former mouthwash
Residual action and influence.Thorough scaling, plaque stain again after 10d, show PLI=0, subject takes other one bottle again to gargle
Saliva is identical with former using process.All mouthwash numbering revealed secretss are reduced to test group, control group by numbering personnel,
Count every group of corresponding PLI.
(4) subject voluntarily uses the guidance of mouthwash
Specified mouthwash supplies it use at home when issuing subject's packet.The dosage for instructing their mouthwashes is 20 millis
Rise, 3 times a day, 30 seconds every time.Not dietary restriction and smoking.
(5) recipient site and test stone
Recipient site：#11, #16, #26, #31 buccal labial surface, #36, #46 lingual surface.Test stone：With 2% Basic Fuchsin in Aqueous Solution
To being dyed by inspection facing, using improvement Qiugley-Hein methods record plaque index (plaqueindex, PLI).
2nd, the result of study of bacterial plaque is suppressed
Plaque index inspection result (the unit of table 3：)
| Group | 0 degree | 1 degree | 2 degree | 3 degree | 4 degree | 5 degree |
| Experimental group | 62 | 76 | 25 | 9 | 3 | 5 |
| Control group | 0 | 28 | 22 | 56 | 52 | 22 |
The testing result of 30 subject's plaque indexs is shown：Experimental group can significantly inhibit tooth bacterium compared with control group
Spot re-forms (P<0.001).
Test example 3 treats the clinical test of halitosis
In in September, 2016 in July, 2017,400 patients, max age 65 years old, minimal ages 18 are screened in 5 hospitals
In year, the halitosis disease caused by stomatitis is all suffered from, sufferer is randomly divided into two groups, the people of experimental group 200, the people of control group 200, tested
Group uses the obtained mouthwash for including the active ingredient of embodiment 1 in test example 1, and control group uses the easypro mouth of three nine-day periods after the winter solstice mouth cleaner antibacterial
Liquid, 3 days time limits are observed, 1 day symptom to patient is comprehensively checked before experiment, periodically checks inquiry patient body during experiment
Situation and impression, and make a record.
Application method：To make the present invention reach optimum therapeuticing effect, first gargled using before mouthwash with clear water, then contain and gargle
Saliva, gargle more than 1 minute, not gargled again with clear water after having gargled.Advised and the concrete condition of oneself is every according to abiding by for doctor
Its selection is a course for the treatment of using 4 times, each 20mL, 3 days.Therapeutic effect is counted after 3 days, the judgment criteria of therapeutic effect is：
Effectively：Malaise symptoms mitigate or partial disappearance；
Cure：Malaise symptoms disappear, and without recurrence；
It is invalid：Malaise symptoms are unchanged or recur.
As a result it is as shown in the table：
To the therapeutic effect of halitosis after the use mouthwash of table 4
| Group | Total number of cases | Age | Cure number of cases | Effective number of cases | Invalid number of cases | Total effective rate |
| Experimental group | 200 | 18~65 | 128 | 68 | 4 | 93.00 |
| Control group | 200 | 18~65 | 96 | 69 | 35 | 82.50 |
Other products are significantly better than by the therapeutic effect of the mouthwash of the results showed that present invention of table 4.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of inhibiting bacteria and diminishing inflammation composition, it is characterised in that in parts by weight, be made up of the following raw material：
3~10 parts of spider freeze-drying powder, 10~20 parts of honeysuckle, 8~12 parts of the coptis, 25~35 parts of gypsum, 10~14 parts of the wind-weed, carefully
Pungent 4~8 parts, 10~20 parts of the dried rhizome of rehmannia, 10~14 parts of the root bark of tree peony, 10~20 parts of Chinese herbaceous peony, 10~14 parts of radix scrophulariae, 8~12 parts of holy basil, jasmine
3~7 parts of jasmine.
2. inhibiting bacteria and diminishing inflammation composition according to claim 1, it is characterised in that in parts by weight, be made up of the following raw material：
7 parts of spider freeze-drying powder, 15 parts of honeysuckle, 10 parts of the coptis, 30 parts of gypsum, 12 parts of the wind-weed, 6 parts of asarum, 15 parts of the dried rhizome of rehmannia, the root bark of tree peony
12 parts, 15 parts of Chinese herbaceous peony, 12 parts of radix scrophulariae, 10 parts of holy basil, 5 parts of Jasmine.
3. inhibiting bacteria and diminishing inflammation composition according to claim 1, it is characterised in that in parts by weight, be made up of the following raw material：
3 parts of spider freeze-drying powder, 10 parts of honeysuckle, 12 parts of the coptis, 25 parts of gypsum, 14 parts of the wind-weed, 4 parts of asarum, 20 parts of the dried rhizome of rehmannia, the root bark of tree peony
10 parts, 20 parts of Chinese herbaceous peony, 10 parts of radix scrophulariae, 12 parts of holy basil, 3 parts of Jasmine.
4. inhibiting bacteria and diminishing inflammation composition according to claim 1, it is characterised in that in parts by weight, be made up of the following raw material：
10 parts of spider freeze-drying powder, 20 parts of honeysuckle, 8 parts of the coptis, 35 parts of gypsum, 10 parts of the wind-weed, 8 parts of asarum, 10 parts of the dried rhizome of rehmannia, the root bark of tree peony
14 parts, 10 parts of Chinese herbaceous peony, 14 parts of radix scrophulariae, 8 parts of holy basil, 7 parts of Jasmine.
5. the preparation method of inhibiting bacteria and diminishing inflammation composition as any one of Claims 1-4, it is characterised in that by raw material spider
Spider freeze-dried powder, honeysuckle, the coptis, gypsum, the wind-weed, asarum, the dried rhizome of rehmannia, the root bark of tree peony, Chinese herbaceous peony, radix scrophulariae, holy basil, Jasmine mixing, alcohol
Carry, filter, obtain inhibiting bacteria and diminishing inflammation composition.
6. preparation method according to claim 5, it is characterised in that the alcohol extracting is：It is soaked in 10 in ethanol water
~20 days.
7. preparation method according to claim 6, it is characterised in that the volume basis of ethanol contains in the ethanol water
Measure as 50%~70%.
8. the preparation method according to claim 6 or 7, it is characterised in that in terms of g/mL, the raw material and ethanol water
Amount ratio be (100~200)：1000.
9. a kind of oral health care product, it is characterised in that including inhibiting bacteria and diminishing inflammation group any one of Claims 1-4
Acceptable auxiliary material on compound, and pharmacy or bromatology.
10. oral health care product according to claim 9, it is characterised in that the oral health care product
Formulation is oral cleansing lotion, chewing gum, toothpaste, tooth gel, tooth powder, mouthwash or tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710772076.XA CN107519377B (en) | 2017-08-31 | 2017-08-31 | Antibacterial and anti-inflammatory composition, preparation method thereof and oral health care product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710772076.XA CN107519377B (en) | 2017-08-31 | 2017-08-31 | Antibacterial and anti-inflammatory composition, preparation method thereof and oral health care product |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107519377A true CN107519377A (en) | 2017-12-29 |
| CN107519377B CN107519377B (en) | 2021-04-06 |
Family
ID=60683148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710772076.XA Active CN107519377B (en) | 2017-08-31 | 2017-08-31 | Antibacterial and anti-inflammatory composition, preparation method thereof and oral health care product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107519377B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010046291A2 (en) * | 2008-10-24 | 2010-04-29 | Henkel Ag & Co. Kgaa | Use of hydroxycinnamic acids and derivatives thereof and/or of plant extracts for treating body odor |
| CN102526597A (en) * | 2012-02-14 | 2012-07-04 | 张秀兰 | Medicament for treating ozostomia and preparation method thereof |
| CN104083662A (en) * | 2014-07-19 | 2014-10-08 | 陈鸿雁 | Mouthwash for eliminating ozostomia caused by stomatitis and preparation method of mouthwash |
| CN104688850A (en) * | 2013-12-04 | 2015-06-10 | 肖峰 | Traditional Chinese medicine mouthwash |
| CN107029021A (en) * | 2017-06-16 | 2017-08-11 | 刘晓梅 | It is a kind of to have oral nursing liquid of therapeutic efficiency and preparation method thereof concurrently |
-
2017
- 2017-08-31 CN CN201710772076.XA patent/CN107519377B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010046291A2 (en) * | 2008-10-24 | 2010-04-29 | Henkel Ag & Co. Kgaa | Use of hydroxycinnamic acids and derivatives thereof and/or of plant extracts for treating body odor |
| CN102526597A (en) * | 2012-02-14 | 2012-07-04 | 张秀兰 | Medicament for treating ozostomia and preparation method thereof |
| CN104688850A (en) * | 2013-12-04 | 2015-06-10 | 肖峰 | Traditional Chinese medicine mouthwash |
| CN104083662A (en) * | 2014-07-19 | 2014-10-08 | 陈鸿雁 | Mouthwash for eliminating ozostomia caused by stomatitis and preparation method of mouthwash |
| CN107029021A (en) * | 2017-06-16 | 2017-08-11 | 刘晓梅 | It is a kind of to have oral nursing liquid of therapeutic efficiency and preparation method thereof concurrently |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107519377B (en) | 2021-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2324472C2 (en) | Composition and methods of care of oral cavity based on morinda citrifolia | |
| CN105770191B (en) | With the composition and its preparation method and application for reducing Periodontal Pathogens active function | |
| CN103536497B (en) | A kind of Traditional Chinese medicinal compound collutory and preparation method thereof | |
| CN109528601B (en) | Compound traditional Chinese medicine mouth wash and preparation method thereof | |
| CN103520502A (en) | Chinese medicinal preparation for treating gingivitis and preparation method thereof | |
| CN104244912A (en) | Natural antibacterial toothpaste composition having effects of alleviating oral pain, killing oral bacteria, and calming nerves | |
| CN107441014A (en) | A kind of evening clothing toothpaste of American-cockroach-extract-containing and preparation method thereof | |
| CN110731931B (en) | Health toothpaste containing miracle fruit effective component | |
| RU2635509C1 (en) | Phytocomposition for oral care | |
| CN102000333B (en) | Immunoglobulin (IgY) antibody oral spray for preventing decayed teeth | |
| CN110731935A (en) | toothpaste for diminishing inflammation and relieving pain | |
| CN107397805B (en) | Improve oral hygiene, prevention and the composition and preparation method for the treatment of mouth disease | |
| CN1234389C (en) | Chinese traditional medicine for treating oral disease and its preparing process | |
| CN106692755B (en) | Traditional Chinese medicine composition with hemostatic, anti-inflammatory and antibacterial functions and preparation method and application thereof | |
| Goadby | The buccal secretions and dental caries | |
| CN107485584A (en) | A kind of oral care composition | |
| CN104258092B (en) | A kind of gargle for treating RAU and periodontosis and preparation method thereof | |
| CN107519377A (en) | A kind of inhibiting bacteria and diminishing inflammation composition and preparation method thereof and oral health care product | |
| CN104955462A (en) | Compositions, uses and methods for treating or preventing dental caries | |
| Duke | Oral sepsis in its relationship to systemic disease | |
| Wahyuningtyas | The Graptophyllum pictum extract effect on acrylic resin complete denture plaque growth | |
| Aldowsari et al. | Clinical efficacy of single use of three different mouthrinses on the level of Streptococcus mutans in saliva | |
| KR20180098048A (en) | Mouthwash containing green tea | |
| JP2001131019A (en) | Carbonized matter of ganoderma lucidum and its use | |
| CN105663017A (en) | Composition for oral caring and preparation method of composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 570100 room 2707, Xinda business building, 48 Guomao Avenue, Haikou City, Hainan Province Applicant after: Hainan spider king Biotechnology Co.,Ltd. Address before: 570000 room 1101, Xinda commercial building, Huafu Road, Longhua District, Haikou City, Hainan Province Applicant before: HAINAN ZHUWANG PHARMACEUTICAL Co.,Ltd. |
|
| CB02 | Change of applicant information | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210315 Address after: 570100 room 2707, Xinda business building, 48 Guomao Avenue, Haikou City, Hainan Province Applicant after: Hainan spider king Biotechnology Co.,Ltd. Applicant after: Zhu Yiqiang Address before: 570100 room 2707, Xinda business building, 48 Guomao Avenue, Haikou City, Hainan Province Applicant before: Hainan spider king Biotechnology Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |