CN107513576A - 一种用于检测遗传性心肌疾病的试剂盒及其应用 - Google Patents

一种用于检测遗传性心肌疾病的试剂盒及其应用 Download PDF

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CN107513576A
CN107513576A CN201710969632.2A CN201710969632A CN107513576A CN 107513576 A CN107513576 A CN 107513576A CN 201710969632 A CN201710969632 A CN 201710969632A CN 107513576 A CN107513576 A CN 107513576A
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张昱
胡庆涛
高琳琳
倪悦涵
麦雪莹
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National Institute of Biological Sciences Beijin
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Abstract

本发明公开了一种遗传性心肌疾病(ARVC&DCM)检测试剂盒及其应用。本发明的ARVC&DCM检测试剂盒包括与遗传性心肌疾病：致心律失常性右室心肌病(ARVC)和扩张型心肌病(DCM)相关的12个基因相匹配的捕获探针。该试剂盒通过Tn5转座酶的方法构建DNA文库，然后利用液相杂交法捕获目标基因片段，通过第二代测序技术测序并分析过滤得到致病突变。本发明的试剂盒与以往产品相比，包含的与ARVC和DCM相关的基因数目更多更全，且与传统方法相比较，Tn5转座酶的方法更为快速简便，并且适用于大规模操作，同时也大大降低了建库的成本。

Description

一种用于检测遗传性心肌疾病的试剂盒及其应用
技术领域
本发明属于生物技术领域，具体涉及一种用于检测遗传性心肌疾病的试剂盒及其应用，特别涉及一种用于检测与致心律失常性右室心肌病和扩张型心肌病相关基因变异的试剂盒。
背景技术
心肌病是以心肌病变为主要表型的一类疾病，是造成猝死的主要原因。遗传因素是心肌病发病的重要原因之一。例如，致心律失常性右室心肌病(ARVC)和扩张型心肌病(DCM)中遗传性的病人占30-50％。揭示遗传性心肌病的分子遗传基础有助于早期诊断和精准治疗。
伴随着第二代测序技术的飞速发展，基因组测序的通量呈现指数级增长，同时测序价格也急速下降，使得通过对大规模的疾病人群测序来研究疾病的遗传基础变为现实可行的方案。其中，相对于全基因组测序或者全外显子组测序方法，候选区域捕获测序方法拥有高测序深度带来的高准确性和低数据量带来的低成本的优势。
发明内容
本发明的一个目的是提供一种用于检测或辅助检测与遗传性心肌疾病相关基因变异的试剂盒。
本发明提供的用于检测或辅助检测与遗传性心肌疾病相关基因变异的试剂盒包括用于检测G1变异的物质；
所述G1为LMNA基因、RYR2基因、CTNNA3基因、PKP2基因、TGFB3基因、JUP基因、DSC2基因、DSG2基因、DES基因、TMEM43基因、DSP基因和/或PLN基因。
上述试剂盒中，所述用于检测G1变异的物质为成套RNA探针；
所述成套RNA探针由用于检测LMNA基因的探针组1、用于检测RYR2基因的探针组2、用于检测CTNNA3基因的探针组3、用于检测PKP2基因的探针组4、用于检测TGFB3基因的探针组5、用于检测JUP基因的探针组6、用于检测DSC2基因的探针组7、用于检测DSG2基因的探针组8、用于检测DES基因的探针组9、用于检测TMEM43基因的探针组10、用于检测DSP基因的探针组11和用于检测PLN基因的探针组12组成。
上述试剂盒中，
所述成套RNA探针中的每条核酸分子的5’端和3’端分别连有接头序列。具体地，每条所述核酸分子的5’端连有的接头序列可为“GAAGCGAGGATCAACT”，3’端连有的接头序列可为“CATTGCGTGAACCGA”。
本发明也保护上述成套RNA探针中每条核酸分子转录后得到的RNA分子。
上述RNA分子中，所述每条RNA分子的UTP均进行生物素标记。
所述RNA分子的制备方法包括如下步骤：
(a1)以连有接头序列的成套RNA探针为模板，采用高保真Phusion酶，使用GCbuffer和HF buffer进行PCR扩增，得到PCR产物。
PCR反应体系如下：5x HF buffer or GC buffer 5微升、dNTPs(10mM)1微升、Oligo F(10uM)2微升、Oligo R(10uM)2微升、连有接头序列的成套RNA探针20ng、PhusionDNA polymerase 0.5微升、ddH2O至50微升。
PCR反应程序如下：98度30秒，98度5秒，55度到58度梯度15秒，72度5秒，循环数20个，最后72度5分钟。
(a2)采用体外转录试剂盒MEGAscrip Kit以步骤(a1)中的PCR产物为模板进行体外转录，得到生物素标记的RNA探针。
体外转录反应体系如下：10X反应缓冲液2微升、ATP 2微升、CTP 2微升、GTP2微升、UTP 1.5微升、生物素标记的UTP 0.5微升、酶2微升、DNA模板(PCR产物)100纳克，双蒸水至20微升。
体外转录反应程序如下：37度保持4小时后加入1微升TURBO，混合后37度保持15分钟。
上述成套RNA探针中每条所述核酸分子按照上述方法进行体外转录后得到的RNA分子中的UTP均进行生物素标记。
上述RNA分子的制备方法也属于本发明的保护范围。
本发明的第二个目的是提供上述成套RNA探针。
本发明的第三个目的是提供一种用于检测或辅助检测与遗传性心肌疾病相关基因变异的成套试剂。
本发明提供的用于检测或辅助检测与遗传性心肌疾病相关基因变异的成套试剂包括上述成套RNA探针。
上述成套试剂中，所述成套RNA探针中的每条核酸分子在所述成套试剂中的终浓度均为(1-10)×10-6pmol/ul。具体地，每条核酸分子在所述成套试剂中的终浓度均为6×10-6pmol/ul。
本发明的第四个目的是提供上述试剂盒或上述成套RNA探针或上述成套试剂的新用途。
本发明提供了上述试剂盒或上述成套RNA探针或上述成套试剂在检测或辅助检测与遗传性心肌疾病相关基因变异中的应用。
本发明还提供了上述试剂盒或上述成套RNA探针或上述成套试剂在制备检测或辅助检测与遗传性心肌疾病相关基因变异的产品中的应用。
本发明提供的第五个目的是提供一种检测或辅助检测与遗传性心肌疾病相关基因变异的方法。
本发明提供的检测或辅助检测与遗传性心肌疾病相关基因变异的方法包括如下步骤：
(1)采用Tn5转座酶方法构建目的基因组DNA文库；
(2)利用液相杂交法将上述成套RNA探针与所述DNA文库杂交，得到杂交产物；
(3)对所述杂交产物进行二代测序，根据测序结果分析目的基因组DNA的变异情况。
上述方法中，所述步骤(1)包括如下步骤：(1-1)按照实施例中表2所示的配方配制反应体系，55摄氏度保持20分钟，得到目的溶液。(1-2)向目的溶液中加入磁珠溶液采用磁珠法除去反应溶液。(1-3)采用磁珠法选择大小为360-500bp的DNA片段，得到用于PCR扩增的DNA文库。(1-4)以步骤(1-3)获得的DNA文库为模板进行PCR扩增，PCR扩增体系如实施例中表4所示，PCR扩增程序如实施例中表5所示。引物序列如实施例中表3所示。
上述方法中，所述步骤(1)和所述步骤(2)之间还包括纯化的步骤。
上述方法中，所述步骤(2)包括如下步骤：(2-1)在纯化后的DNA文库管中加入人源Cot-1DNA、鲑鱼精子DNA和文库两端接头序列的封闭DNA对DNA文库进行预处理，得到预处理文库。(2-2)向预处理文库中加入生物素标记的RNA探针和Superase-In RNA酶抑制剂，得到探针溶液。(2-3)将预处理文库与探针溶液进行杂交。具体步骤如下：A、在一个EP管中加入预热到65℃的杂交缓冲液；B、将一个热块加热到98℃，另一个热块加热到65℃，然后将DNA文库98℃中变性5分钟后迅速将其移入65℃热块中平衡5分钟；C、当DNA文库平衡2.5分钟的时候，将探针溶液放入65℃热块中预热；D、当探针溶液预热2.5分钟的时候，在DNA文库中加入预热的杂交缓冲液，然后加入探针溶液，每条探针在反应体系中的终浓度均为6×10- 6pmol/ul；E、将DNA文库用封口膜封紧，放入65℃杂交箱中过夜。(2-4)过夜杂交完成以后，将DNA文库加入链霉亲和素标记的磁珠中，捕获DNA/RNA杂合链。(2-5)变性DNA/RNA杂合链，得到捕获DNA。(2-6)利用实施例中表7所示的PCR反应体系对捕获DNA进行扩增，得到PCR扩增产物，并用磁珠纯化PCR扩增产物。
上述试剂盒或上述成套试剂或上述应用中，所述遗传性心肌疾病为致心律失常性右室心肌病(ARVC)和/或扩张型心肌病(DCM)。
上述试剂盒或上述成套试剂或上述应用中，所述与遗传性心肌疾病相关基因为LMNA基因、RYR2基因、CTNNA3基因、PKP2基因、TGFB3基因、JUP基因、DSC2基因、DSG2基因、DES基因、TMEM43基因、DSP基因和/或PLN基因。
本发明提供的用于检测或辅助检测与遗传性心肌疾病相关基因变异的试剂盒包括与遗传性心肌疾病：致心律失常性右室心肌病和扩张型心肌病相关的12个基因相匹配的捕获探针。该试剂盒通过Tn5转座酶的方法构建DNA文库，然后利用液相杂交法捕获目标基因片段，通过第二代测序技术测序并分析过滤得到致病突变。本发明的试剂盒与以往产品相比，包含的与ARVC和DCM相关的基因数目更多更全，且与传统方法相比较，Tn5转座酶的方法更为快速简便，并且适用于大规模操作，同时也大大降低了建库的成本。
附图说明
图1为Sanger测序结果和捕获测序结果。A为纯合突变的测序结果；B为杂合突变的测序结果。
图2为目标区域覆盖均一性评估数据。横坐标为read覆盖的重数，纵坐标为占目标区域的百分比。
具体实施方式
下述实施例中所使用的实验方法如无特殊说明，均为常规方法。
下述实施例中所用的材料、试剂等，如无特殊说明，均可从商业途径得到。
下述实施例中的定量试验，均设置三次重复实验，结果取平均值。
下述实施例中的5x TAPS-DMF溶液配方如下：50mM TAPS-NaOH(pH8.5)，25mMMgCl2，体积分数为50％的DMF。
下述实施例中的Assembled Tn5是将18ul浓度为1ug/ul的Tn5溶液和2ul浓度为100uM的Pre-annealed引物MEDA-U2溶液混匀得到的，其中，Tn5的终浓度为0.9ug/ul，Pre-annealed引物MEDA-U2的终浓度为10uM。Tn5记载于如下文献“Tn5transposase andtagmentation procedures for massively scaled sequencing projects”中，公众可从北京生命科学研究所获得。Pre-annealed引物MEDA-U2溶液的制备方法如下：(1)将10ul浓度为200uM的Tn5MErev([phos]CTGTCTCTTATACACATCT)溶液与10ul浓度为200uM的Tn5ME-A(TCGTCGGCAGCGTCAGATGTGTATAAGAGACAG)溶液混匀，经热处理后，得到MEDS-UA溶液；热处理条件如下95度10分钟，五个循环的95度1秒(其中每个循环下降2度)，300个循环的85度1秒(其中每个循环下降0.2度)，25度保持1分钟；(2)将10ul浓度为200uM的Tn5MErev([phos]CTGTCTCTTATACACATCT)与10ul浓度为200uM Tn5ME-B(TCGTCGGCAGCGTCAGATGTGTATAAGAGACAG)溶液混匀，经热处理后，得到MEDS-UB溶液；热处理条件同步骤(1)；(3)将MEDS-UA溶液与MEDS-UB溶液等体积混匀，得到Pre-annealed引物MEDA-U2溶液。
下述实施例中的磁珠溶液的制备方法如下：吸出1毫升SpeedBeads(GE货号65152105050250)放置磁力架2分钟，去上清液，加入TE溶液震荡混匀后再放置磁力架上静置2分钟，去上清液，反复清洗2次，最后beads混合在1毫升TE溶液中，得到TE溶液洗过的SpeedBeads；称量9克PEG8000至50毫升Falcon管中，然后加入10毫升5摩尔氯化钠溶液、500微升1摩尔Tris-HCl(pH 8.0)缓冲溶液和100微升0.5摩尔EDTA溶液，加入双蒸水至约49毫升再加入1毫升TE溶液洗过的SpeedBeads，最后加入27.5微升Tween20。
下述实施例中的杂交缓冲液(1.5ml)的配方如下：500ul 20×SSPE(thermo，AM9767)、240ul去离子水、20ul 50×Denhardt’s溶液(thermo，750018)、20ul 10％SDS(amresco，0227-1kg)和20ul 0.5M EDTA(thermo，AM9260G)。
下述实施例中的冲洗缓冲液(25ml)的配方如下：19.7ml去离子水、5ml 5M NaCl溶液(thermo，AM9759)、250ul 1M Tris-HCl溶液(thermo，15567027)、50ul 0.5M EDTA溶液(thermo，AM9260G)。
下述实施例中的low-stringency缓冲液(25ml)的配方如下：23.5ml去离子水、1.25ml 20×SSC(thermo，AM9765)、250ul 10％SDS(amresco，0227-1kg)。
下述实施例中的high-stringency缓冲液(25ml)的配方如下：24.6ml去离子水、125ul 20×SSC(thermo，AM9765)、250ul 10％SDS(amresco，0227-1kg)。
实施例1、遗传性心肌疾病(ARVC&DCM)检测试剂盒及使用方法
一、遗传性心肌疾病(ARVC&DCM)检测试剂盒
本发明的遗传性心肌疾病(ARVC&DCM)检测试剂盒包括与遗传性心肌疾病：致心律失常性右室心肌病(Arrhythmogenic right ventricu-lar cardiomyopathy，ARVC)和扩张型心肌病(Dilatedcardiomyopathy，DCM)相关的12个基因相匹配的捕获探针。
1、捕获探针的设计
选择与遗传性心肌疾病：致心律失常性右室心肌病(ARVC)和扩张型心肌病(DCM)相关的12个候选基因，并确定其在染色体上的物理位置。本发明选择的12个候选基因包括4个与ARVC和DCM相关的基因和8个与ARVC相关的基因。具体信息如表1所示。
表1、12个候选基因
捕获探针的设计方法如下：利用IDT公司的在线探针设计工具(https://sg.idtdna.com/sessionTimeout.aspx)，参数为2X tilling和118个核苷酸长度。同时使用Illumina公司在线探针设计工具进行设计；根据两个公司设计的探针，手动调整目标区域的探针数量，达到每个区域都有探针覆盖，并且对难以捕获的区域使用更多的探针；对设计的所有探针进行全基因组比对，确定是否有脱靶，如果发现有脱靶，则重新设计该探针；加入内参探针。
2、捕获探针序列的制备
(1)捕获探针序列
本文(包括发明内容和实施例)根据目标基因设计的捕获探针序列均指权利要求书中的权利要求2所示的成套RNA探针，其由用于检测LMNA基因的探针组1、用于检测LMNA基因的探针组2、用于检测RYR2基因的探针组3、用于检测CTNNA3基因的探针组4、用于检测PKP2基因的探针组5、用于检测TGFB3基因的探针组6、用于检测JUP基因的探针组7、用于检测DSC2基因的探针组7、用于检测DSG2基因的探针组8、用于检测DES基因的探针组9、用于检测TMEM43基因的探针组10、用于检测DSP基因的探针组11和用于检测PLN基因的探针组12组成。
上述成套RNA探针中的每条核酸分子的5’端均连有接头序列“GAAGCGAGGATCAACT”，3’端均连有接头序列“CATTGCGTGAACCGA”。
(2)生物素标记的RNA探针的制备
A、探针模板的扩增
分别以连有接头序列的RNA探针为模板，采用高保真Phusion酶(thermo F-530L)，分别使用GC buffer和HF buffer进行PCR扩增，分别得到PCR产物。
PCR反应体系如下：5x HF buffer or GC buffer(life，F-518)5微升、dNTPs(10mM)(genatar，A113-01)1微升、Library-F(10uM)(擎科嘉美)2微升、Library-R(10uM)(擎科嘉美)2微升、合成的DNA oligo 20ng、Phusion DNA polymerase(life，F-530L)0.5微升、ddH2O至50微升。
Oligo F:CATACGATTTAGGTGACACTATAGAAGCGAGGATCAACT；
Oligo R:GAGCTTCGGTTCACGCAATG。
PCR反应程序如下：98度30秒，98度5秒，55度到58度梯度15秒，72度5秒，循环数20个，最后72度5分钟。
PCR结束后混合PCR产物，用qiagen胶回收试剂盒(qiagen 28606)回收，回收后的产物测量浓度后用于体外转录反应的DNA模板。
B、体外转录RNA
采用体外转录试剂盒MEGAscrip Kit(thermo AM1330)，以步骤A中的DNA模板为模板进行体外转录，获得生物素标记的RNA探针。
体外转录反应体系如下：10X反应缓冲液2微升、ATP 2微升、CTP 2微升、GTP2微升、UTP 1.5微升、生物素标记的UTP 0.5微升、酶2微升、DNA模板100纳克，双蒸水至20微升。
体外转录反应程序如下：37度保持4小时后加入1微升TURBO，混合后37度保持15分钟。
C、RNA探针的回收
采用水饱和酚氯仿(Solarbio w0250)回收法回收生物素标记的RNA探针。定量后分装。
二、遗传性心肌疾病(ARVC&DCM)检测试剂盒的使用方法
1、DNA建库
本发明的遗传性心肌疾病(ARVC&DCM)检测试剂盒运用Tn5转座酶的方法(SimonePicelli,et al.2014)进行基因组DNA建库。具体步骤如下：
(1)基因组DNA的质量检测
基因组DNA样品浓度大于70纳克每微升，总质量大于1.5微克，A260/A280比值大于1.8。
(2)目标溶液的制备
按照表2中的配方配制反应体系。将反应体系置于PCR仪中，55摄氏度保持20分钟，然后向反应体系中加入0.1％SDS来终止反应，混匀后室温保持5分钟，得到目标溶液。
表2、反应体系
组分 用量
5x TAPS-DMF溶液 10微升
基因组DNA 500纳克
Assembled Tn5 2微克(0.5微克每微升)
双蒸水 至50微升
(3)用磁珠法除去反应溶液(适用于8连排操作)
首先用0.1X TE溶液(Solarbio，T1120)将目标溶液体积补充至80微升，再加入1.2-1.5倍体积的磁珠溶液，吹吸混匀后室温放置10分钟，上磁力架上放置5分钟，充分吸附后吸取并去掉上清液，用新鲜配制的150微升的80％乙醇清洗，清洗两次，每次30秒，使用200微升枪头移去上清液，保持1.5微升管子在磁力架上。清洗后，敞开盖子放置室温10-15分钟，等待磁珠干燥后，用105微升双蒸水洗脱，取100微升转移到新的管子。
(4)磁珠法选择片段大小(适用于8连排操作)
采用磁珠法选择大小为360-500bp的DNA片段。具体步骤如下：向100微升上清液中加入0.6倍体积的磁珠溶液(60微升)，吹吸混匀后室温放置10分钟，上磁力架上放置5分钟，充分吸附后，转移上清液至新的管子里，再加入0.15倍原始体积的磁珠(15微升)，吹吸混匀后室温放置10分钟，上磁力架上放置5分钟，将充分吸附后，吸取并去掉上清液。再用新鲜配制的150微升的80％乙醇清洗，清洗两次，每次30秒，使用200微升枪头移去上清液，保持1.5微升管子在磁力架上。清洗后，敞开盖子放置室温10-15分钟，等待磁珠干燥后，用22微升双蒸水洗脱，等待上清澄清后，吸取20微升至新的管子中，得到用于PCR扩增的DNA文库，并用Qubit测量其浓度，所得DNA总量应在40纳克以上继续进行PCR扩增。
(5)DNA文库扩增
以步骤(4)获得的DNA文库为模板进行PCR扩增，每个样品分成两管进行扩增反应。引物序列如表3所示，PCR扩增体系如表4所示，PCR扩增程序如表5所示。
表3、引物序列
index2-i5-N501 AATGATACGGCGACCACCGAGATCTACACTAGATCGCTCGTCGGCAGCGTC
index1-i7-N701 CAAGCAGAAGACGGCATACGAGATTCGCCTTAGTCTCGTGGGCTCGG
index1-i7-N702 CAAGCAGAAGACGGCATACGAGATCTAGTACGGTCTCGTGGGCTCGG
index1-i7-N703 CAAGCAGAAGACGGCATACGAGATTTCTGCCTGTCTCGTGGGCTCGG
index1-i7-N704 CAAGCAGAAGACGGCATACGAGATGCTCAGGAGTCTCGTGGGCTCGG
index1-i7-N705 CAAGCAGAAGACGGCATACGAGATAGGAGTCCGTCTCGTGGGCTCGG
index1-i7-N706 CAAGCAGAAGACGGCATACGAGATCATGCCTAGTCTCGTGGGCTCGG
index1-i7-N707 CAAGCAGAAGACGGCATACGAGATGTAGAGAGGTCTCGTGGGCTCGG
index1-i7-N708 CAAGCAGAAGACGGCATACGAGATCCTCTCTGGTCTCGTGGGCTCGG
index1-i7-N709 CAAGCAGAAGACGGCATACGAGATAGCGTAGCGTCTCGTGGGCTCGG
index1-i7-N710 CAAGCAGAAGACGGCATACGAGATCAGCCTCGGTCTCGTGGGCTCGG
index1-i7-N711 CAAGCAGAAGACGGCATACGAGATTGCCTCTTGTCTCGTGGGCTCGG
index1-i7-N712 CAAGCAGAAGACGGCATACGAGATTCCTCTACGTCTCGTGGGCTCGG
表4、PCR扩增体系
表5、PCR反应程序
(6)纯化(适用于8连排操作)
合并两管PCR扩增产物成一管，采用磁珠法进行纯化，得到纯化后PCR产物。具体步骤如下：加入0.8倍体积的磁珠溶液，用于去除300bp以下的小片段，吹吸混匀后室温放置10分钟，上磁力架上放置5分钟，充分吸附后，上磁力架上放置5分钟，将充分吸附后，吸取并去掉上清液后，用新鲜配制的150微升的80％乙醇清洗，清洗两次，每次30秒，使用200微升枪头移去上清液，保持1.5微升管子在磁力架上。清洗后，敞开盖子放置室温10-15分钟，等待磁珠干燥后，用23微升双蒸水充分洗脱，等待上清澄清后，吸取20微升至新的管子中，得到纯化后的DNA文库，并用Qubit测量其浓度。纯化后的DNA文库总量应大于500纳克。取一微升跑8％PAGE胶，DNA文库的大小应集中在500-600bp。
2、探针捕获
(1)将步骤1中的纯化后的DNA文库首先用Qubit定量，每个文库取250纳克，一次混合20个文库，总体积不超过50微升。
(2)DNA文库和生物素标记的RNA探针杂交
A、用Qubit定量建好的全基因组文库，每个文库取250纳克，共20个文库(5ug)混合与1.5ml的EP管中，总体积不得超过50微升，如果体积过大，可用真空离心浓缩至50微升，此管标记名称为DNA文库。
B、在DNA文库管中加入25微升的浓度为1mg/ml人源Cot-1DNA(life，15279-101)、25微升的浓度为10mg/ml的鲑鱼精子DNA(thermo，15632-011)、由擎科嘉美公司合成的文库两端接头序列的封闭DNA(AATGATACGGCGACCACCGAGATCTACACNNNNNNNNTCGTCGGCAGCGTCAGATGTGTATAAGAGACAG和CAAGCAGAAGACGGCATACGAGATNNNNNNNNGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAG，其中，NNNNNNNN所表示的序列为表6所示)各加15微升(200uM)，最终体积为130微升。
表6、NNNNNNNN所表示的序列
C、在一个新的1.5ml EP管中加入20微克生物素标记的RNA探针，10微升20U/μlSuperase-In RNA酶抑制剂(life，AM2696)，用水补足至65微升，此管命名为探针。
D、在一个新的1.5ml EP管中加入140微升预热到65℃的杂交缓冲液，此管命名为杂交缓冲液。
E、将一个热块加热到98℃，另一个热块加热到65℃，将DNA文库98℃中变性5分钟，然后迅速将DNA文库移入65℃热块中平衡5分钟。
F、当DNA文库平衡2.5分钟的时候，将探针放入65℃热块中预热。
G、当探针预热2.5分钟以后，在DNA文库中加入130微升预热的杂交缓冲液，然后加入60微升的探针，最终体积为320微升，每条探针在反应体系中的终浓度均为6×10-6pmol/ul。用100微升移液器吹吸10次混匀，避免出现气泡。
H、将DNA文库用封口膜封紧，放入65℃杂交箱中过夜。
(3)准备链霉亲和素标记的M280磁珠
A、在两个1.5ml EP管中分别加入250微升链霉亲和素M-280(life，11206D)和1毫升的冲洗缓冲液，涡旋振荡30秒混匀。
B、在磁力架上静置2分钟分离磁珠，然后去掉上清。
C、加入825微升冲洗缓冲液，涡旋振荡30秒混匀。
D、重复步骤(3)中的B和C，共三次。
E、用825微升磁珠冲洗缓冲液重悬磁珠。
(4)捕获杂交的DNA/RNA
A、过夜杂交完成以后，将160微升DNA文库加入825微升的链霉亲和素标记的磁珠中，涡旋振荡10秒钟，室温翻转混匀孵育30分钟。
B、在磁力架上静置2分钟分离磁珠，然后去掉上清。
C、加入825微升low-stringency缓冲液，室温翻转混匀孵育15分钟。
D、打开杂交箱，65℃预热high-stringency缓冲液。
E、在磁力架上静置2分钟分离磁珠，然后去掉上清。
F、加入825微升65℃预热的high-stringency缓冲液，涡旋振荡10秒钟，65℃混合振荡器中10分钟。
G、在磁力架上静置2分钟分离磁珠，然后去掉上清。
H、重复步骤(4)中的F和G，共三次。
(5)变性DNA/RNA杂合链
A、加入200微升的0.1N NaOH，涡旋振荡后室温孵育10分钟。
B、在磁力架上静置2分钟分离磁珠。
C、将上清转移到新的EP管，加入200微升的1M Tris-Cl来中和NaOH。
D、用1.2倍体积的SpeedBeads磁珠纯化DNA，得到捕获的DNA，最终溶于40微升去核酸酶的双蒸水中。
(6)富集捕获的DNA
A、利用如下表7所示的PCR的反应体系对捕获的DNA进行扩增，得到PCR扩增产物。引物序列如下：library_F：caagcagaagacggcatacga；library_R：aatgatacggcgaccaccga。
表7、PCR反应体系
50微升 5.5X
5xHiFi buffer(life，F-518) 10微升 55微升
library_F(10uM)(擎科嘉美) 2微升 11微升
library_R(10uM)(擎科嘉美) 2微升 11微升
dNTP 1微升 5.5微升
Phusion(life，F-530L) 1微升 5.5微升
DNA 19微升
H2O 15微升 82.5微升
B、用1.2倍体积的SpeedBeads磁珠纯化PCR扩增产物，最终溶于20微升去核酸酶的双蒸水中。用Qubit定量然后储存在-20℃冰箱中等待测序。
3、测序及数据分析
利用Illumina公司HiSeq测序平台进行测序，每个样本测序1-1.5G的原始数据，通过BWA软件默认参数将原始数据比对到参考基因组上得到每个样本特异的变异，再通过在公共数据库中的人群频率和突变功能预测得到该样本的致病突变。
实施例2、遗传性心肌疾病(ARVC&DCM)检测试剂盒的应用
一、突变样本的检测
采用实施例1中的遗传性心肌疾病(ARVC&DCM)检测试剂盒检测118例经临床确诊为心肌病的患者样本(包括家族遗传性和散发性样本)的突变情况，并通过sanger法进行测序验证。
结果表明：本发明的试剂盒与sanger法测序结果一致率达到100％，详细结果如表8和图1所示。
表8、23个突变Sanger验证结果
二、遗传性心肌疾病(ARVC&DCM)检测试剂盒的性能检测
本发明的遗传性心肌疾病(ARVC&DCM)检测试剂盒捕获基因数目可达12，捕获碱基数目可达44.6k，外显子数目可达258，Mapping比例(hg19)可达97％，平均测序深度可达524，0.2x平均测序深度以上比例95％，目标区域数据富集程度大约为28％，覆盖的均一度较高，15x覆盖以上的区域达到98％(图2)，与Sanger测序结果的一致性可达100％(图2和表9)。
表9、遗传性心肌疾病(ARVC&DCM)检测试剂盒性能评估表
捕获基因数目 12
捕获碱基数目 44.6k
外显子数目 258
Mapping比例(hg19) 97％
目标区域数据比例 28％
平均测序深度 524
15x以上区域比例 98％
0.2x平均测序深度以上比例 95％
与Sanger测序结果的一致性 100％
序列表
<110>北京生命科学研究所
<120>一种用于检测遗传性心肌疾病的试剂盒及其应用
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<170>PatentIn version 3.5
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gaagcagcgt gagtttgaga gccggctggc ggatgcgctg caggaactgc gggcccagca 60
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cactggggta gacatgctgt acaacccttc cctggccctg acccttggac ctggttccat 60
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cgacgaggat gaggatggag atgacctgct ccatcaccac cacgtgagtg gtagccgccg 60
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gctgaggccg agcctgcact ggggccaccc agccaggcct gggggcagcc tctccccagc 60
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tagaaagtcc agaagctcta aatattatta aagaaggaca tattaaatct attatctcac 60
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<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>14
ccctctggat ttcccacagg agaaaaggtt ctgcaggacg atgagttcac ctgtgacctc 60
ttccgattcc tgcaactact ctgtgaggga cacaactcag gtttgtgagt ccccggaa 118
<210>15
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>15
gctccagggt ccttgcactg ggaatcaaca gagtttggca cacagcaggc tgtgggatgc 60
tgtggtcggc tttcttcatg tgtttgccca tatgcagatg aagctgtcgc aggtaaac 118
<210>16
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>16
ctgtggtcgg ctttcttcat gtgtttgccc atatgcagat gaagctgtcg caggtaaact 60
aactaactgc cttcctctct cttaaatgac aaactggaga ctgtaatcat cagcaaat 118
<210>17
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>17
agttggacag tgtcacatcc ctgatccaag cagccaaaaa tttaatgaat gctgtagtgc 60
aaacagtgaa aatgtcttac attgcctcaa ccaagatcat ccgaatccag agtcctgc 118
<210>18
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>18
ttggcaataa ttaacaaaac ctcctggaat aatagctctt ttttctcttt tttccctaca 60
gttggacagt gtcacatccc tgatccaagc agccaaaaat ttaatgaatg ctgtagtg 118
<210>19
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>19
aagcaaaagc tcattgaatg tgttggatga taatcaattt gtggacatct caaagaagat 60
ctatgataca attcatgata tcagatgttc agtcatgatg attcgggtaa gtttgctt 118
<210>20
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>20
tttattttaa cagtaattcc tgaatttgta acacaagtga atgttgcctt ggaagcctta 60
agcaaaagct cattgaatgt gttggatgat aatcaatttg tggacatctc aaagaaga 118
<210>21
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>21
gcgtacatgg gagaatcata tacatgtcct cactgaagcc gtagatgaca ttacaagcat 60
tgatgacttc cttgctgtat ctggtatgtt tttattcttt taatttgttt attttctc 118
<210>22
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>22
ggctgcaaga cccaaaagtc aagcggtcaa aaacaccatg gaaatgtaca agcgtacatg 60
ggagaatcat atacatgtcc tcactgaagc cgtagatgac attacaagca ttgatgac 118
<210>23
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>23
gtaatttttt caatccttat ctttatagat tattaatgct gcacttgctt tggctgcaag 60
acccaaaagt caagcggtca aaaacaccat ggaaatgtac aagcgtacat gggagaat 118
<210>24
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>24
attctctgtg ggcacacacg gaactgcatc atgcctacaa gaaggtaaga acatgaacaa 60
ggaatgtgtc atagttaaca gagccaggta ataatggccc acttgacttg accctggg 118
<210>25
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>25
tccttttctt ttcagctatg cctccaacaa agcaagtaaa gctgcttccg tccttctgta 60
ttctctgtgg gcacacacgg aactgcatca tgcctacaag aaggtaagaa catgaaca 118
<210>26
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>26
catccagaaa attatggcca ttagtgcagg cgatgcgtaa gtccttcagt tctgcccgtc 60
agctgcctcc ctttcccctc accagcctgt gtgtaaataa tccggttgtg aatgtgcg 118
<210>27
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>27
ttgaacaaca taatccaaaa cagttaccag aatgcacgcg accttctaaa caccgggggc 60
atccagaaaa ttatggccat tagtgcaggc gatgcgtaag tccttcagtt ctgcccgt 118
<210>28
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>28
ttgaacaaca taatccaaaa cagttaccag aatgcacgcg accttctaaa caccgggggc 60
atccagaaaa ttatggccat tagtgcaggc gatgcgtaag tccttcagtt ctgcccgt 118
<210>29
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>29
ctgacacagt cccgagtact gaccttctca ttgaaactac agcctctgcc tgttacacat 60
tgaacaacat aatccaaaac agttaccaga atgcacgcga ccttctaaac accggggg 118
<210>30
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>30
ctgacacagt cccgagtact gaccttctca ttgaaactac agcctctgcc tgttacacat 60
tgaacaacat aatccaaaac agttaccaga atgcacgcga ccttctaaac accggggg 118
<210>31
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>31
ttgttttttt tttcattttg tagccaaaga aactctccct gatttggttt ccatcattcc 60
tgacacagtc ccgagtactg accttctcat tgaaactaca gcctctgcct gttacaca 118
<210>32
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>32
cagcacaccc gaaagatgct gcatgttggt gacccaagtg tgaaaaagac agccatctcg 60
ctgctgagga atctgtcccg gaatctttct ctgcagaatg aaattggtga gtcggtat 118
<210>33
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>33
cagcacaccc gaaagatgct gcatgttggt gacccaagtg tgaaaaagac agccatctcg 60
ctgctgagga atctgtcccg gaatctttct ctgcagaatg aaattggtga gtcggtat 118
<210>34
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>34
cagcacaccc gaaagatgct gcatgttggt gacccaagtg tgaaaaagac agccatctcg 60
ctgctgagga atctgtcccg gaatctttct ctgcagaatg aaattggtga gtcggtat 118
<210>35
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>35
tcacaaaaca gatgccgaca tcagtggctc agacagttgt ccagaaggaa agtggcctgc 60
agcacacccg aaagatgctg catgttggtg acccaagtgt gaaaaagaca gccatctc 118
<210>36
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>36
tcacaaaaca gatgccgaca tcagtggctc agacagttgt ccagaaggaa agtggcctgc 60
agcacacccg aaagatgctg catgttggtg acccaagtgt gaaaaagaca gccatctc 118
<210>37
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>37
tcacaaaaca gatgccgaca tcagtggctc agacagttgt ccagaaggaa agtggcctgc 60
agcacacccg aaagatgctg catgttggtg acccaagtgt gaaaaagaca gccatctc 118
<210>38
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>38
tcacaaaaca gatgccgaca tcagtggctc agacagttgt ccagaaggaa agtggcctgc 60
agcacacccg aaagatgctg catgttggtg acccaagtgt gaaaaagaca gccatctc 118
<210>39
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>39
tcacaaaaca gatgccgaca tcagtggctc agacagttgt ccagaaggaa agtggcctgc 60
agcacacccg aaagatgctg catgttggtg acccaagtgt gaaaaagaca gccatctc 118
<210>40
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>40
tcacaaaaca gatgccgaca tcagtggctc agacagttgt ccagaaggaa agtggcctgc 60
agcacacccg aaagatgctg catgttggtg acccaagtgt gaaaaagaca gccatctc 118
<210>41
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>41
tctacagaaa acttaatgtt atcgtgaaat caaatacaat agcacttata ggatatgtct 60
cacaaaacag atgccgacat cagtggctca gacagttgtc cagaaggaaa gtggcctg 118
<210>42
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>42
tctacagaaa acttaatgtt atcgtgaaat caaatacaat agcacttata ggatatgtct 60
cacaaaacag atgccgacat cagtggctca gacagttgtc cagaaggaaa gtggcctg 118
<210>43
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>43
tctacagaaa acttaatgtt atcgtgaaat caaatacaat agcacttata ggatatgtct 60
cacaaaacag atgccgacat cagtggctca gacagttgtc cagaaggaaa gtggcctg 118
<210>44
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>44
tacacacaag aagcatcctt aggagctctg cagaacctca cggccggaag tggaccagtg 60
agtattgggc ctgatttcct actttttaaa ataatgatat tgtagacata cctacatt 118
<210>45
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>45
tgtggcattc cattgttata aggatgtatc tgtccttgat cgccaaaagt gtccgcaact 60
acacacaaga agcatcctta ggagctctgc agaacctcac ggccggaagt ggaccagt 118
<210>46
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>46
aactcaagaa tctcatgata acagaagcat tgcttacgct gacggagaat atcatcatcc 60
ccttttctgg gtggcctgaa ggagactacc caaaagcaaa tggtttgctc gattttga 118
<210>47
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>47
gttttcatgg taactctgtg cttttctagg tttgctgtgg aatttgtcat ctaatgacaa 60
actcaagaat ctcatgataa cagaagcatt gcttacgctg acggagaata tcatcatc 118
<210>48
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>48
tgctgaagca aaccagagac ttggagacta aaaaacaaat aacaggtagt gcttactgaa 60
cattgaagaa cctaacacat ttgcacccca gccagatgcc ttacatcatc tctttttc 118
<210>49
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>49
agacaatgac aacaaattgg aggtggctga actaaatggg gtacctcggc tgctccaggt 60
gctgaagcaa accagagact tggagactaa aaaacaaata acaggtagtg cttactga 118
<210>50
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>50
agacaatgac aacaaattgg aggtggctga actaaatggg gtacctcggc tgctccaggt 60
gctgaagcaa accagagact tggagactaa aaaacaaata acaggtagtg cttactga 118
<210>51
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>51
gttcagaatg aagacgttca gcgagctgtg tgtggggcct tgagaaactt agtatttgaa 60
gacaatgaca acaaattgga ggtggctgaa ctaaatgggg tacctcggct gctccagg 118
<210>52
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>52
tgcttcttcc ccaggttaac cagcttcgtg gcatcctcaa gcttctgcag ctcctaaaag 60
ttcagaatga agacgttcag cgagctgtgt gtggggcctt gagaaactta gtatttga 118
<210>53
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>53
gtttgtatta cattgaatgc cttgatgcca catcaaaatt aatattagaa atatgcatct 60
gcttcttccc caggttaacc agcttcgtgg catcctcaag cttctgcagc tcctaaaa 118
<210>54
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>54
cagcacgagt gcttccagaa atctgaagct cggaagaggg tgagtgtcat cttcagtcca 60
ttgcaaagcg caacacactt tcacttctat tatggtgact ttgcacactg aaaccaat 118
<210>55
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>55
cagcacgagt gcttccagaa atctgaagct cggaagaggg tgagtgtcat cttcagtcca 60
ttgcaaagcg caacacactt tcacttctat tatggtgact ttgcacactg aaaccaat 118
<210>56
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>56
gtatgctcga ggcagaccac atgctgccat ccaggatttc tgctgcagct actttcatac 60
agcacgagtg cttccagaaa tctgaagctc ggaagagggt gagtgtcatc ttcagtcc 118
<210>57
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>57
gtatgctcga ggcagaccac atgctgccat ccaggatttc tgctgcagct actttcatac 60
agcacgagtg cttccagaaa tctgaagctc ggaagagggt gagtgtcatc ttcagtcc 118
<210>58
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>58
cctcctggca tcagagctcc ttccacagca cccgcacgct gagggaagct gggcccagtg 60
tcgccgtgga ttccagcggg aggagagcgc acttgactgt cggccaggcg gccgcagg 118
<210>59
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>59
cgggcaggtc aggccgctgg tgcccctgca gcccgtcact cagaacaggg cttccaggtc 60
ctcctggcat cagagctcct tccacagcac ccgcacgctg agggaagctg ggcccagt 118
<210>60
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>60
agccgcagca tgggcaacct cttggagaag gagaactacc tgacggcagg gctcactgtc 60
gggcaggtca ggccgctggt gcccctgcag cccgtcactc agaacagggc ttccaggt 118
<210>61
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>61
ccgtttttga cagcatccct gccaacccgg ccctgctcac gtaccccagg ccagggacca 60
gccgcagcat gggcaacctc ttggagaagg agaactacct gacggcaggg ctcactgt 118
<210>62
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>62
ccttgctgcg tgccccagga cctggagccc ctgaccatcc tgtactatgt tgggaggacc 60
cccaaagtgg agcagctctc caacatggtg gtgaagtctt gtaaatgtag ctgagacc 118
210>63
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>63
atgtcccttc ccaggtgctg ggactgtaca acactctgaa ccctgaagca tctgcctcgc 60
cttgctgcgt gccccaggac ctggagcccc tgaccatcct gtactatgtt gggaggac 118
<210>64
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>64
atcgaaatgg tgaaaggagg acaccagacc tcggaatcct gccggggggc tggccaccat 60
cacaccctgg actcctgcag gggaggacac acggaggtgg acaactgcag atacactt 118
<210>65
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>65
ctgctcaggg agtttgtggc accgtgggat caggaatcaa aaacggaggt caggagacca 60
tcgaaatggt gaaaggagga caccagacct cggaatcctg ccggggggct ggccacca 118
<210>66
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>66
tgatttagcc cagcagaacc taattgtatc aaacacagaa gctcctggag atgacaaagt 60
ggtaagtagt ctggcttttt aaataaatac aaaggatgaa ttcgcttata atgcgtat 118
<210>67
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>67
ctgtttacgc tggtctgtgg ggcttctggg acgtctaaac aaccaaaagt aattcctgat 60
gatttagccc agcagaacct aattgtatca aacacagaag ctcctggaga tgacaaag 118
<210>68
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>68
atgcatccaa ctacaggcgt gatcaccaca acatcatctc agctagacag agaggtaaca 60
taaacaataa aacctgatta taacgtggct attcaatagt acctgtataa ctcctgta 118
<210>69
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>69
acacacgcct gaagtactcc atcattgggc aggtgccacc atcacccacc ctattttcta 60
tgcatccaac tacaggcgtg atcaccacaa catcatctca gctagacaga gaggtaac 118
<210>70
<211>118
<212>DNA
<213>人工序列(Artificial Sequence)
<400>70
ctaaagaaaa agttctaagg cgcgccaaga gaagatgggc tccaattcct tgttcgatgc 60
tagaaaactc cttgggtcct tttccacttt tccttcaaca ggtaccgttt tctttctt 118

Claims (10)

1.一种用于检测或辅助检测与遗传性心肌疾病相关基因变异的试剂盒，其包括用于检测G1变异的物质；
所述G1为LMNA基因、RYR2基因、CTNNA3基因、PKP2基因、TGFB3基因、JUP基因、DSC2基因、DSG2基因、DES基因、TMEM43基因、DSP基因和/或PLN基因。
2.根据权利要求1所述的试剂盒，其特征在于：
所述用于检测G1变异的物质为成套RNA探针；
所述成套RNA探针由用于检测LMNA基因的探针组1、用于检测LMNA基因的探针组2、用于检测RYR2基因的探针组3、用于检测CTNNA3基因的探针组4、用于检测PKP2基因的探针组5、用于检测TGFB3基因的探针组6、用于检测JUP基因的探针组7、用于检测DSC2基因的探针组7、用于检测DSG2基因的探针组8、用于检测DES基因的探针组9、用于检测TMEM43基因的探针组10、用于检测DSP基因的探针组11和用于检测PLN基因的探针组12组成；
所述探针组1由如下核酸分子组成：
GCACTCCGACTCCGAGCAGTCTCTGTCCTTCGACCCGAGCCCCGCGCCCTTTCCGGGACCCCTGCCCCGCGGGCAGCGCTGCCAACCTGCCGGCCATGGAGACCCCGTCCCAGCGGCG；CCCTGCCCCGCGGGCAGCGCTGCCAACCTGCCGGCCATGGAGACCCCGTCCCAGCGGCGCGCCACCCGCAGCGGGGCGCAGGCCAGCTCCACTCCGCTGTCGCCCACCCGCATCACCC；CGCCACCCGCAGCGGGGCGCAGGCCAGCTCCACTCCGCTGTCGCCCACCCGCATCACCCGGCTGCAGGAGAAGGAGGACCTGCAGGAGCTCAATGATCGCTTGGCGGTCTACATCGAC；GGCTGCAGGAGAAGGAGGACCTGCAGGAGCTCAATGATCGCTTGGCGGTCTACATCGACCGTGTGCGCTCGCTGGAAACGGAGAACGCAGGGCTGCGCCTTCGCATCACCGAGTCTGA；CGTGTGCGCTCGCTGGAAACGGAGAACGCAGGGCTGCGCCTTCGCATCACCGAGTCTGAAGAGGTGGTCAGCCGCGAGGTGTCCGGCATCAAGGCCGCCTACGAGGCCGAGCTCGGGG；AGAGGTGGTCAGCCGCGAGGTGTCCGGCATCAAGGCCGCCTACGAGGCCGAGCTCGGGGATGCCCGCAAGACCCTTGACTCAGTAGCCAAGGAGCGCGCCCGCCTGCAGCTGGAGCTG；ATGCCCGCAAGACCCTTGACTCAGTAGCCAAGGAGCGCGCCCGCCTGCAGCTGGAGCTGAGCAAAGTGCGTGAGGAGTTTAAGGAGCTGAAAGCGCGGTGAGTTCGCCCAGGTGGCTG；AGCAAAGTGCGTGAGGAGTTTAAGGAGCTGAAAGCGCGGTGAGTTCGCCCAGGTGGCTGCGTGCCTGGCGGGGAGTGGAGAGGGCGGCGGGCCGGCGCCCCTGGCCGGCCGCAGGAAG；GGGAGACAGGAAATGCCCAGGGGCTGGGAGACCCTCTGCTCTTCTGCTCCCTTCCTGTGTGCTGCCTGGCAATGGGGAACTCTGAGGGCTGGTGAGCAGGGCTGCTGAGGAGTGGGTC；TGCTGCCTGGCAATGGGGAACTCTGAGGGCTGGTGAGCAGGGCTGCTGAGGAGTGGGTCTAAGGAGTCCCTGCAGGGCTGGGCCAGCTCCTCCACCTCCCCTTTGTCTTCCCCTCCCA；CCCCTCTCTTCCCTCTTTCTGAGATCAGATTTGCCAGTGATGGGAAGAGTTAGAAACAGGATGCCCAGCCCTTCTCGCCTCAAGAGGCCACTGGGATGCAGCCACTCCTGTGCTTGGG；GATGCCCAGCCCTTCTCGCCTCAAGAGGCCACTGGGATGCAGCCACTCCTGTGCTTGGGGAACCTGGAGGATGCAAGGGAAAGGACTGGCACTCTGCTGGCACAGCACCCGGCCTGGG；GAACCTGGAGGATGCAAGGGAAAGGACTGGCACTCTGCTGGCACAGCACCCGGCCTGGGGCAGGACACGGGCGAAGCCAGGGTCTCCCCTGTGAGCACTAGAGGATTTCCCGACCCCT；GCAGGACACGGGCGAAGCCAGGGTCTCCCCTGTGAGCACTAGAGGATTTCCCGACCCCTGCCCGGGTATTGTGTGCCTGAGCATGAGTCACCTGAGGGGCCCAGGTTCCCACCCTTCC；CCTGGGAGCCTGGCACTGTCTAGGCACACAGACTCCTTCTCTTAAATCTACTCTCCCCTCTCTTCTTTAGCAATACCAAGAAGGAGGGTGACCTGATAGCTGCTCAGGCTCGGCTGAA；CTCTTCTTTAGCAATACCAAGAAGGAGGGTGACCTGATAGCTGCTCAGGCTCGGCTGAAGGACCTGGAGGCTCTGCTGAACTCCAAGGAGGCCGCACTGAGCACTGCTCTCAGTGAGA；GGACCTGGAGGCTCTGCTGAACTCCAAGGAGGCCGCACTGAGCACTGCTCTCAGTGAGAAGCGCACGCTGGAGGGCGAGCTGCATGATCTGCGGGGCCAGGTGGCCAAGGTGAGGCCA；AGCGCACGCTGGAGGGCGAGCTGCATGATCTGCGGGGCCAGGTGGCCAAGGTGAGGCCACCCTGCAGGGCCCACCCATGGCCCCACCTAACACATGTACACTCACTCTTCTACCTAGG；CCAGTTCTTGTGTTCTGTGACCCCTTTTCCTCATCTCTGCCTGCTTCCTCACAGCTTGAGGCAGCCCTAGGTGAGGCCAAGAAGCAACTTCAGGATGAGATGCTGCGGCGGGTGGATG；GGCAGCCCTAGGTGAGGCCAAGAAGCAACTTCAGGATGAGATGCTGCGGCGGGTGGATGCTGAGAACAGGCTGCAGACCATGAAGGAGGAACTGGACTTCCAGAAGAACATCTACAGT；CTGAGAACAGGCTGCAGACCATGAAGGAGGAACTGGACTTCCAGAAGAACATCTACAGTGAGGTGGGGACTGTGCTTTGCAAGCCAGAGGGCTGGGGCTGGGTGATGACAGACTTGGG；GAGGTGGGGACTGTGCTTTGCAAGCCAGAGGGCTGGGGCTGGGTGATGACAGACTTGGGCTGGGCTAGGGGGGACCAGCTGTGTGCAGAGCTCGCCTTCCTGAGTCCCTTGCCCTAGT；TCTTGGCCTCCCAGGAACTAATTCTGATTTTGGTTTCTGTGTCCTTCCTCCAACCCTTCCAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGG；CAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGCGTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGC；GAAGCAGCGTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGAAGACTTATTCTGCCAAGGTG；ATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGAAGACTTATTCTGCCAAGGTGCTTGCTCTCGATTGGTTCCCTCACTGCCTCTGCCCTTGGCAGCCCTACCCTTACCCACG；GGCTGTAGCAGTGATGCCCAACTCAGGCCTGTGCCTCCACCCCTCCCAGTCACCACAGTCCTAACCCTTTGTCCTCCCCTCCAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACA；CCTAACCCTTTGTCCTCCCCTCCAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGTCGCGCATCCGCATCGACAGC；GCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGTCGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGGTGATACCCCACCTCACCCCTCTCTC；CTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGGTGATACCCCACCTCACCCCTCTCTCCAGGGGCCTAGAGTCTGGGCCGGATGCAGGCTGGAAGCCCAGGGTTGGGGGTGGGGGTG；CCCACGTCCCTCCTTCCCCATACTTAGGGCCCTTGGGAGCTCACCAAACCCTCCCACCCCCCTTCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGGACTCACTGGCCCGT；CCCTTCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGGACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCG；GAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGCAGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCC；GGCAAGGATGCAGCAGCAGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGGAGAGGTGGGCT；TGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGGAGAGGTGGGCTGGGGAGACGTCGGGGAGGTGCTGGCAGTGTCCTCTGGCCGGCAACTGGCCTTGACTAGA；CTGGCAGTGTCCTCTGGCCGGCAACTGGCCTTGACTAGACCCCCACTTGGTCTCCCTCTCCCCAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCT；CCCCAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCGTCACCAAAAAGCGCAAACTGGAGTCC；CTCACTCATCCCAGACACAGGGTGGGGGCAGCGTCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGA；ACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGGTGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGTAGGCT；GGAGGTGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGTAGGCTCCTGCTCAGGGTCTAAGGGGATACAGCTGCATCAGGGAGAGAGTGGCAAGACAGAAGGA；GCAAGATACACCCAAGAGCCTGGGTGAGCCTCCCCGACCTTCCTCTTCCCTATCTTCCCGGCAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAGATGATCCCTTG；GGCAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAGATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGGTGAG；CTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGGTGAGTGGCAGGGCGCTTGGGACTCTGGGGAGGCCTTGGGTGGCGATGGGAGCGCTGGGGTAAG；GACGGTGAGTGGCAGGGCGCTTGGGACTCTGGGGAGGCCTTGGGTGGCGATGGGAGCGCTGGGGTAAGTGTCCTTTTCTCCTCTCCAGATCTGGGCTGCAGGAGCTGGGGCCACCCAC；TGGGGTAAGTGTCCTTTTCTCCTCTCCAGATCTGGGCTGCAGGAGCTGGGGCCACCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCT；AGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTGGGGAAGTAAGTAGGCCTGGGCCTGGCTGCTTGC；GCGTACGGCTCTCATCAACTCCACTGGGGAAGTAAGTAGGCCTGGGCCTGGCTGCTTGCTGGACGAGGCTCCCCCTGATGGCCAACATCGGAGCCAGCTGCCCCCAACCCAAGTTTGC；CACTGGGGTAGACATGCTGTACAACCCTTCCCTGGCCCTGACCCTTGGACCTGGTTCCATGTCCCCACCAGGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGA；TGTCCCCACCAGGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACCACCACGTGAGTGGTAGCCGCC；CGACGAGGATGAGGATGGAGATGACCTGCTCCATCACCACCACGTGAGTGGTAGCCGCCGCTGAGGCCGAGCCTGCACTGGGGCCACCCAGCCAGGCCTGGGGGCAGCCTCTCCCCAG；GCTGAGGCCGAGCCTGCACTGGGGCCACCCAGCCAGGCCTGGGGGCAGCCTCTCCCCAGCCTCCCCGTGCCAAAAATCTTTTCATTAAAGAATGTTTTGGAACTTTACTCGCTGGCCT；CTGGAGCCTGGTTGGGCCTGAGTGGTCAGTCCCAGACTCGCCGTCCCGCCTGAGCCTTGTCTCCCTTCCCAGGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAACCTGC；TCTCCCTTCCCAGGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAACCTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTGCCGACAAGGCATCTGCCAGC；GCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTGCCGACAAGGCATCTGCCAGCGGCTCAGGAGCCCAGGTGGGCGGACCCATCTCCTCTGGCTCTTCTGCCTCCAGTGTCAC；GGCTCAGGAGCCCAGGTGGGCGGACCCATCTCCTCTGGCTCTTCTGCCTCCAGTGTCACGGTCACTCGCAGCTACCGCAGTGTGGGGGGCAGTGGGGGTGGCAGCTTCGGGGACAATC；GGTCACTCGCAGCTACCGCAGTGTGGGGGGCAGTGGGGGTGGCAGCTTCGGGGACAATCTGGTCACCCGCTCCTACCTCCTGGGCAACTCCAGCCCCCGAACCCAGGTGAGTTGTCTC；TGGTCACCCGCTCCTACCTCCTGGGCAACTCCAGCCCCCGAACCCAGGTGAGTTGTCTCTGCTTTGTCTCCAAATCCTGCAGGCGGGTCCCTGGTCATCGAGGGGTAGGACGAGGTGG；CTACCTCCCTTCTAGGGGCCAGGGGAGGGAGGGTCTGGGTCCAGGCCCTGCTGCTCACACCTCTCTCCTCTGTTTTCTCTCTTAGAGCCCCCAGAACTGCAGCATCATGTAATCTGGG；CCTCTCTCCTCTGTTTTCTCTCTTAGAGCCCCCAGAACTGCAGCATCATGTAATCTGGGACCTGCCAGGCAGGGGTGGGGGTGGAGGCTTCCTGCGTCCTCCTCACCTCATGCCCACC；CCCCAGCCCCGGGGTGAGTCCATTCTCCCAGGTACCAGCTGCGCTTGCTTTTCTGTATTTTATTTAGACAAGAGATGGGAATGAGGTGGGAGGTGGAAGAAGGGAGAAGAAAGGTGAG；TTATTTAGACAAGAGATGGGAATGAGGTGGGAGGTGGAAGAAGGGAGAAGAAAGGTGAGTTTGAGCTGCCTTCCCTAGCTTTAGACCCTGGGTGGGCTCTGTGCAGTCACTGGAGGTT；TTTGAGCTGCCTTCCCTAGCTTTAGACCCTGGGTGGGCTCTGTGCAGTCACTGGAGGTTGAAGCCAAGTGGGGTGCTGGGAGGAGGGAGAGGGAGGTCACTGGAAAGGGGAGAGCCTG；
所述探针组2由如下核酸分子组成：
GAAGGCAGCGCCAGGGGCCGCCGCCGCCGCCGAGCTCCGCGGGGCTCGGGAGCCGGCCCCGGCGAGGAGGCGCGGAACCATGGCCGATGGGGGCGAGGGCGAAGACGAGATCCAGTTC；CGGCGAGGAGGCGCGGAACCATGGCCGATGGGGGCGAGGGCGAAGACGAGATCCAGTTCCTGCGAACTGTAAGCGCCGTGCGTCGCGTGTGCTGTCAGGGGAAGGGGGCGTCAGGGC；CTAAAATAATGTTCTTCAAGATATGATTTGGACTGTGCAGTCATGTCACGTCTCACTTATTTTTCCCTCTCTTTCTCCCCCTTTGCAGGATGATGAAGTGGTTCTGCAGTGCACCGCA；TTTTTCCCTCTCTTTCTCCCCCTTTGCAGGATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACT；ACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGGTGGGATGAAGTCTTTCAAGGCTATTCA；TTGTTTCTTGGAGTCCACTTCCAATTCCAAGGTGGGATGAAGTCTTTCAAGGCTATTCAAATATGCAAGTTTTACTAGTGGCATTGAAGTTATTTATGAGCTCTCTACTATTTTCTGT；AGGTAAGCTGGGTCTGGATGCTTGATGAAGATGATGCTGCTGACTGCTCTTCCTCTTTCTGTGCAGAATGTGCCCCCAGACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCT；TGTGCAGAATGTGCCCCCAGACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGGCAAGT；CTGTCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGGCAAGTACCCAATTTATGTAGACTTGTAGTATTTTAATGAGCTCAGCTACTATAGGAACAATTTC；TTCATTTAAATGACAGTAATTGAAACATTGCTAGGTATTTGTTTGTTTGTTATTTATTTTGGCTTTTTCTTTCCACAGCAAGTTGATGTGGAAAAATGGGTATGTGTTTCCATGTATT；TGGCTTTTTCTTTCCACAGCAAGTTGATGTGGAAAAATGGGTATGTGTTTCCATGTATTTGCAAAGAAATTGTGATCTAAAAGTGCATGCTTGCTCTCGCCTCTAATCTTTCATTTTG；TTGTTTACATAGCTCCATTTAGGATAACGGAGTCTTTATAAATAAGAGATATTTTTAAGGAAGTCTTTGAGATCGTGTCTATTTAATGTTTCCTCTCTTTTCCTTATGCCCCTACAGA；TATTTTTAAGGAAGTCTTTGAGATCGTGTCTATTTAATGTTTCCTCTCTTTTCCTTATGCCCCTACAGAAATTCATGATGAAGGTAAGACATCTTAATATATATGCTATGTATATATA；AGAGAGTATTTTATCAACTTGGTTAAGTTACTCTTTTGTGTTTTTCTCTCTTGTTCTCCTTTTTTCTCTTCTCTCTAAAGACTGCTCAAGGTGGTGGTCATCGAACACTCCTCTACGG；TTTTTTCTCTTCTCTCTAAAGACTGCTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGCCATTCCTATAGTGGCATGGTGAGTAGGCATTTGATTTCAT；ACATGCCATATTGCTGCGCCATTCCTATAGTGGCATGGTGAGTAGGCATTTGATTTCATCTCCCTGTGGTCATGCTGATCCATTTGGGGGTACATGGTCTGCAAATGCTGGTAGCATC；CAGAGCAACCTTGTCTCAAACACAAACAACAGACGAACAAAACCTCTACTTACAACTACTGATTTTGTACTTTGTAGTATCTGTGCTGCCTGTCCACCTCCCGGTCTTCAACTGATAA；TGATTTTGTACTTTGTAGTATCTGTGCTGCCTGTCCACCTCCCGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGTAAGCATCTTGTGCTGCGGG；GCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGTAAGCATCTTGTGCTGCGGGAAGCCAGGTTCAGAGAGAACCCTGCAGGGGTTGGATTGGAAGAAGCCGGGAAATACGAT；AAAGAAAATAGATTTTAATTAAGAGGAACTTTTTCATGTTTCACATATCCGTATATCTGCAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCTAAGCAGCGATCAGAAGGAGAA；CAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGGT；AAAGTACGAGTTGGAGATGACCTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGGTAAGTGTGGAAAGTAGGATCATGTATCTGCTGATATGCTAAATGACAAGTCAATAAAATG；CTAGAAGCACTTACATGTTACAGCTTACCAGAGCCTGAAGTGATGCCTCCTTTTGCCTCTTGATACAGCACTTGTCTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCA；TTGATACAGCACTTGTCTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGTAAAAACT；GACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGTAAAAACTCCACTTCAATTAGAGGGCCTGTCCTTGCTGCAAAGTTGACAGTCATCTTTGGAATTGTG；GGCTATCAGCACCTGACACTGACAGTCCAGACCTGAATGATTTTTTATCCTTACAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGACGAGTGTCTCACT；ATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAGCGGAGGTTAGTACCTGAGCTCATTGCATT；GTCCCTTCAGGAGAACATGGTGAAGAGCAGCGGAGGTTAGTACCTGAGCTCATTGCATTGAGACTTGCACTCTTTTGCCTTGATGTAATGTTTTAAAAACTAGGGATCTATTCATTCA；AATTAGCTTCAAAAAATTAGAGTCCAAAGAATGAAACATGTTTAACTCACATTTGGGCTTTTGTTTGTTTGTTGAAACAGAACTGTTCATTATGAAGGTGGCGCTGTGTCTGTTCATG；TTTGTTTGTTTGTTGAAACAGAACTGTTCATTATGAAGGTGGCGCTGTGTCTGTTCATGCACGTTCCCTTTGGAGACTAGAGACGCTAAGAGTTGCGTAAGTAGAACTTCTAAACACA；CACGTTCCCTTTGGAGACTAGAGACGCTAAGAGTTGCGTAAGTAGAACTTCTAAACACAGCCTAATGCACCAAGTGTACCAAATAGCTCAGCGTTGTGCTTCTGTGTCAGCCTGTGAT；ATATGTTTTAATAGCTACTCCTTCTGTGATTGTGGGTGCTATTGGATCAAGTCCTAACTGTTTTCATTAGGTGGAGTGGAAGCCACATAAGATGGGGACAGCCATTCCGACTACGCCA；GTTTTCATTAGGTGGAGTGGAAGCCACATAAGATGGGGACAGCCATTCCGACTACGCCATGTCACAACAGGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTCTACTCATGGACA；TGTCACAACAGGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTCTACTCATGGACAAAGAGAAAGCTGATGTAAAATCAACAGCATTTACCTTCCGGTCTTCCAAGGTGAGACAG；AAGAGAAAGCTGATGTAAAATCAACAGCATTTACCTTCCGGTCTTCCAAGGTGAGACAGAAAATATTTTGGGTTTCCTATAAATGTTACCCGGTCATATTTCCTTTGATGTTAGAAAG；ATTCTATTGCCATACACTAGTATTTTTGAAATGTTTACTGACCTTTTTTTCCTCCTCTCCCCTTAGGAAAAATTGGATGTAGGGGTGAGAAAAGAAGTAGATGGCATGGGAACATCTG；CCCTTAGGAAAAATTGGATGTAGGGGTGAGAAAAGAAGTAGATGGCATGGGAACATCTGAAATAAAATACGGTGACTCAGTATGCTATATACAACATGTAGACACAGGCCTATGGCTT；AAATAAAATACGGTGACTCAGTATGCTATATACAACATGTAGACACAGGCCTATGGCTTACTTACCAGTCTGTGGACGTGAAATCCGTGAGAATGGGATCTATACAACGTAAGGTAAG；ACTTACCAGTCTGTGGACGTGAAATCCGTGAGAATGGGATCTATACAACGTAAGGTAAGGTGATAGAAAAAAACATAATTTATAGAAGTAATTTTTTATGAATACACAAGCACAAGTC；GCTCAGCTGTTTGAGTACACATCTCCCTAACTCTAGTTTGGAAAAGAGACGTTGGGAGTAATGGCCTTATTTTTGCTTTCTTACAGGCTATTATGCATCATGAAGGCCACATGGATGA；AATGGCCTTATTTTTGCTTTCTTACAGGCTATTATGCATCATGAAGGCCACATGGATGATGGCATAAGTTTGTCGAGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGGA；TGGCATAAGTTTGTCGAGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGGAGCACAGTCTTCCTTTTCAATAGATTTATAAGGTACTTTTTCTTTTGTAGGCGTAGTTGT；GCACAGTCTTCCTTTTCAATAGATTTATAAGGTACTTTTTCTTTTGTAGGCGTAGTTGTTTGATACTTCATTTTCATTTCTTTATTGGATATGCAAATAGACAATTTAAAAGTATGCT；ATTAATGCCTGAAATCATCTATAAATGGAAAAATGATAAAATTGTGAATCACTGACAATAGAGAAATGTTTATGGTTTATTTTAGGGGCCTTGATGCTCTCAGCAAGAAAGCGAAGGC；AGAGAAATGTTTATGGTTTATTTTAGGGGCCTTGATGCTCTCAGCAAGAAAGCGAAGGCTTCCACAGTCGATTTGCCTATAGAGTCCGTAAGCCTAAGTCTGCAGGATCTCATTGGCT；TTCCACAGTCGATTTGCCTATAGAGTCCGTAAGCCTAAGTCTGCAGGATCTCATTGGCTACTTCCACCCCCCAGATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGAGCC；ACTTCCACCCCCCAGATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGAGCCCTGAAGAATCGGCAAAATCTCTTCCAGGAAGAGGTCCGTTTCTATCAACACTCATTTCT；CTGAAGAATCGGCAAAATCTCTTCCAGGAAGAGGTCCGTTTCTATCAACACTCATTTCTCTTCTGTTATTCTCTTGTAAAAACAGCTTCTTGGTTGGGAAAATTTTCCATCTATTTTG；CAACTTAGCATTTTTAGTCTGTAAGCAGAATGACAGTTTTGGATGTCTGATTGTGATTTTTTTTTTTTTTAACGTTCCAGGGAATGATCAACCTCGTGCTTGAGTGCATAGACCGTTT；TTTTTTTTTTTAACGTTCCAGGGAATGATCAACCTCGTGCTTGAGTGCATAGACCGTTTGCACGTCTACAGCAGTGCAGCACACTTTGCTGATGTTGCTGGGCGAGAAGCAGGAGAGT；GCACGTCTACAGCAGTGCAGCACACTTTGCTGATGTTGCTGGGCGAGAAGCAGGAGAGTCTTGGAAATCCATTCTGAATTCTCTGTATGAGTTGCTGGGTAAGAAGCATGATTGGGTT；CTTGGAAATCCATTCTGAATTCTCTGTATGAGTTGCTGGGTAAGAAGCATGATTGGGTTCATAGCAACAGAGTTATCTATTTAAAATGTCCATAAATGGACTAGGTGTGATGGCTCAT；GCATATTAGCTTATCTCAATTTTCGAGCTAGAAAATCACATAAAGGTGAAATCTATTTCTTCTTTTGCAGCGGCTCTAATTAGAGGAAATCGTAAAAACTGTGCTCAATTTTCTGGCT；TTCTTTTGCAGCGGCTCTAATTAGAGGAAATCGTAAAAACTGTGCTCAATTTTCTGGCTCCCTCGACTGGTTGATCAGCAGATTGGAAAGACTGGAAGCTTCTTCAGGTATGTTTTCT；CCCTCGACTGGTTGATCAGCAGATTGGAAAGACTGGAAGCTTCTTCAGGTATGTTTTCTAGTTTTTTCCTTGTTGTGATAGATCACTCCTATTTTTCTTTGCTTCGTATCCTTTAAGA；ATGCACCTATGTAGAAAAAGGAAGACACTGGTCATTGTACACCAATTAATCATGTGTTTTTTTTCCTCTTTCTTTGTTTTATCTTTAGGCATTCTGGAAGTTTTACACTGTGTTTTAG；TTTTTCCTCTTTCTTTGTTTTATCTTTAGGCATTCTGGAAGTTTTACACTGTGTTTTAGTAGAAAGTCCAGAAGCTCTAAATATTATTAAAGAAGGACATATTAAATCTATTATCTCA；TAGAAAGTCCAGAAGCTCTAAATATTATTAAAGAAGGACATATTAAATCTATTATCTCACTTTTAGACAAACATGGAAGAAATCACAAGGTAAATGAACTATTTTATTTCCCTGAATG；CTTTTAGACAAACATGGAAGAAATCACAAGGTAAATGAACTATTTTATTTCCCTGAATGAATTCTCAAATCCTTTTAGATATATTTTTAAATACAATAACTTTTAAAAAGTGTGTCAA；GGGAAGGAAGGAAGGGAGGGAGGGAGGGAGGGAAAGCAGGGAGGGAGGGAGGATCAGCTGAAAGTAATTTCTCTTTTCAGGTTCTGGATGTCTTGTGCTCACTCTGTGTTTGCCACGG；GAAAGTAATTTCTCTTTTCAGGTTCTGGATGTCTTGTGCTCACTCTGTGTTTGCCACGGGGTTGCAGTCCGTTCTAACCAGCATCTCATCTGTGACAATCTCCTACCAGGAAGAGACT；GGTTGCAGTCCGTTCTAACCAGCATCTCATCTGTGACAATCTCCTACCAGGAAGAGACTTGTTATTGCAGACACGTCTTGTGAACCATGTCAGCAGGTAAATTCAGACAGACAATGTC；TGTTATTGCAGACACGTCTTGTGAACCATGTCAGCAGGTAAATTCAGACAGACAATGTCACCTGACAGGTACCATAATAAAAGAATTAATGTTCTTGCCCTGTAGCTGATACTATATG；TACACAAGTGAAATTGTGAGATGTAAATGAAAACAATGAAAGGTTTTTTTGGACTTTCCTTACATGTGATTCCCGTCTCTTTAAAGCATGAGACCCAATATTTTTCTGGGCGTCAGTG；TTACATGTGATTCCCGTCTCTTTAAAGCATGAGACCCAATATTTTTCTGGGCGTCAGTGAAGGTTCTGCTCAGTATAAGAAATGGTACTATGAATTGATGGTGGACCACACAGAGCCC；AAGGTTCTGCTCAGTATAAGAAATGGTACTATGAATTGATGGTGGACCACACAGAGCCCTTTGTGACAGCTGAAGCAACTCACCTGCGAGTGGGCTGGGCTTCCACTGAAGGATATTC；TTTGTGACAGCTGAAGCAACTCACCTGCGAGTGGGCTGGGCTTCCACTGAAGGATATTCTCCCTACCCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGATGATCTCTTCT；TCCCTACCCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGATGATCTCTTCTCCTATGGATTTGATGGCCTTCATCTCTGGTCAGGTACGTACTATCCATTTTCTTTCACC；CCTATGGATTTGATGGCCTTCATCTCTGGTCAGGTACGTACTATCCATTTTCTTTCACCGTGTTCCAGAAGATCTTTTGCTGGGCATTTCTGAAAGCTATTGGTGCTGCTTCCATTAG；AAATCTTTTGACTTTGGCTCTGAAGCTGATTCTCTGAGATAAAAAAATACATGACCTTCCTTAATGTTTTCCCCCCAATAGGTTGTATTGCTCGTACTGTAAGCTCACCAAACCAACA；CTTAATGTTTTCCCCCCAATAGGTTGTATTGCTCGTACTGTAAGCTCACCAAACCAACATCTGTTAAGAACTGATGATGTCATCAGTTGCTGTTTAGATCTGAGTGCCCCAAGCATCT；TCTGTTAAGAACTGATGATGTCATCAGTTGCTGTTTAGATCTGAGTGCCCCAAGCATCTCGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAGAATTTCAACATCGATGGC；CGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAGAATTTCAACATCGATGGCCTCTTCTTTCCAGTCGTTAGTTTCTCTGCAGGAATAAAGTTAGTATGTCTATGTTTTTT；CTCTTCTTTCCAGTCGTTAGTTTCTCTGCAGGAATAAAGTTAGTATGTCTATGTTTTTTGGTCTCTTTCCTTTCTCATTTCTCATACCTCCACAGAAGACTCTGCACTGCCATTGCCC；GATTTTGTGAATTAGAAAACTTTAATGTACACCAGAGATAAAATTGACTCTAACGTGCATCCTCTTTAGAGTACGCTTTCTGCTTGGAGGGCGACATGGAGAATTCAAATTTCTTCCT；TCCTCTTTAGAGTACGCTTTCTGCTTGGAGGGCGACATGGAGAATTCAAATTTCTTCCTCCACCTGGGTATGCTCCTTGTTATGAAGCTGTTCTGCCAAAAGAAAAGTTGAAAGTGGA；CCACCTGGGTATGCTCCTTGTTATGAAGCTGTTCTGCCAAAAGAAAAGTTGAAAGTGGAACACAGCCGAGAGTACAAGCAAGAAAGAACTTACACACGCGACCTGCTGGGCCCCACAG；ACACAGCCGAGAGTACAAGCAAGAAAGAACTTACACACGCGACCTGCTGGGCCCCACAGTTTCCCTGACGCAAGCTGCCTTCACACCCATCCCTGTGGATACCAGCCAGGTACCAAGA；TTTCCCTGACGCAAGCTGCCTTCACACCCATCCCTGTGGATACCAGCCAGGTACCAAGATCCACTCGAATGGCAATCACTGGTATTGCAGTCATGCTGATACACAGTGGCTTTACACT；GACTGTTGGCACTGCATCTTATTGCATTTGTTTCTGATGTGTCTTTTTTCTTTTTGTAAATTTTAGATCGTGTTGCCTCCTCATCTAGAAAGAATAAGAGAAAAACTGGCAGAGAATA；ATTTTAGATCGTGTTGCCTCCTCATCTAGAAAGAATAAGAGAAAAACTGGCAGAGAATATCCATGAACTCTGGGTTATGAATAAAATTGAGCTTGGCTGGCAGTATGGTCCGGTATGT；TCCATGAACTCTGGGTTATGAATAAAATTGAGCTTGGCTGGCAGTATGGTCCGGTATGTAATTTTGAAATTTATTTTCAGATTCTGTGAATACATCTTTCTGAAAACATAACTTTTTC；GTTGAATTCCATTGCTAGTGCCTGGCATTGGAGACTATTTTATGTCAATTTCCTGTCCTGTTTCAGGTTAGAGATGACAACAAGAGACAACACCCATGCCTGGTGGAGTTCTCCAAGC；GTTTCAGGTTAGAGATGACAACAAGAGACAACACCCATGCCTGGTGGAGTTCTCCAAGCTGCCTGAACAGGAGCGCAATTACAACTTACAAATGTCGCTTGAGACCCTGAAGTGAGTT；TGCCTGAACAGGAGCGCAATTACAACTTACAAATGTCGCTTGAGACCCTGAAGTGAGTTTCTTAACTTTTTCTATTTTCCAACCTGCCTTCCCTGAAAAAAAAAAAAAAAAAAAAAAA；TGCTACTGCTGCTGTCTTGGGTTATTCTGGACATAGAGAAGAAATGATCACACTTATCTCTGGTTTTGTTTTCCAGGACTTTGTTGGCATTAGGATGTCATGTGGGTATATCAGATGA；CTGGTTTTGTTTTCCAGGACTTTGTTGGCATTAGGATGTCATGTGGGTATATCAGATGAACATGCTGAAGACAAGGTGAAAAAAATGAAGCTACCCAAGAAGTAAGTTGAATGACTAA；ACATGCTGAAGACAAGGTGAAAAAAATGAAGCTACCCAAGAAGTAAGTTGAATGACTAAGCAATATTAAATAATCTGTGTAGAGATTTAGTGCAACCAAATAACTCTTGATGGACACA；AATGATATTTACAGAGATTTTTATGAAAAGGCCAATTATACACAAATTTCTTTGTCTCTGATTTGTAGTTACCAGCTGACAAGTGGATACAAGCCTGCCCCTATGGACCTGAGCTTTA；GATTTGTAGTTACCAGCTGACAAGTGGATACAAGCCTGCCCCTATGGACCTGAGCTTTATCAAACTCACCCCATCACAAGAAGCAATGGTGGACAAGTTGGCAGAAAATGCACATAAT；TCAAACTCACCCCATCACAAGAAGCAATGGTGGACAAGTTGGCAGAAAATGCACATAATGTGTGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATCCAACAGGTACATGG；GTGTGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATCCAACAGGTACATGGGAATTAGCATTTGGTCTGAGACTTACTTAAGTGGGAATTAGCATAATTTGTAACAGGAA；ATGTATTTGGTAGCTACTTATTTCTAAAAGCCCTTGGTATTGCTTTGACGGCTGCACCCTGTGTTTTCCTGCAGGACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCTACACTCT；TGTGTTTTCCTGCAGGACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCTACACTCTTCTGGATGACCGAACCAAGAAATCCAACAAGGACAGCCTCCGCGAGGCTGTGCGCACGC；TCTGGATGACCGAACCAAGAAATCCAACAAGGACAGCCTCCGCGAGGCTGTGCGCACGCTGCTGGGGTACGGCTACAACTTGGAAGCACCAGATCAAGATCATGGTATTTTGGTTTTA；TGCTGGGGTACGGCTACAACTTGGAAGCACCAGATCAAGATCATGGTATTTTGGTTTTACTTTCCTCTTCTTCGGTTGCAAGATGATGTAGTAGTTCTTTAAAGCCAAATAAATGAAT；TTATTTATGATATCTTTCCTTCTCTTTCACCTCCCCATCCAATGACCACCAGAAATCTCTGTCCATTTCCCAGCAGCCAGAGCCGAAGTGTGCAGCGGCACCGGGGAAAGGTTCCGAA；TGTCCATTTCCCAGCAGCCAGAGCCGAAGTGTGCAGCGGCACCGGGGAAAGGTTCCGAATCTTCCGTGCCGAGAAGACCTATGCAGTGAAGGCCGGACGGTGGTATTTTGAATTTGAG；TCTTCCGTGCCGAGAAGACCTATGCAGTGAAGGCCGGACGGTGGTATTTTGAATTTGAGACGGTCACTGCTGGAGACATGAGGGTTGGTTGGAGTCGTCCTGGTTGTCAACCGGATCA；ACGGTCACTGCTGGAGACATGAGGGTTGGTTGGAGTCGTCCTGGTTGTCAACCGGATCAGGAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTCAAGGTGAGTGGACTTT；GGAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTCAAGGTGAGTGGACTTTGTCCTGTGCCAGTCATCTGTACGTGCTGGAGGCTCATCTCCTCTGCTGTTCCTCTTGGT；GGGTGGGTGCGATTTTCCTGGCTTAGTCTGTGACAAGGGACTTTTCTGTCCTCTGTATAGGCCCAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCTCTTGGCAAGCAGGCGATG；GGCCCAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCTCTTGGCAAGCAGGCGATGTCGTGGGGTGTATGGTTGACATGAACGAACACACCATGATGTTCACACTGAATGGTGAA；TCGTGGGGTGTATGGTTGACATGAACGAACACACCATGATGTTCACACTGAATGGTGAAATCCTTCTTGATGATTCAGGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGG；ATCCTTCTTGATGATTCAGGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGGTAAGTCTACTATGTTTTGTGTTTTTTTTAAGTTTGCAGCACAAGGAAGCTTTCATCCTG；TATGTTTGATAATTCTATACTAACAGGATCATATACTAATGGTACTAAAACTTGATTTTTTTTTTCTTCCCAGGATTCATACCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGA；TTTTTTCTTCCCAGGATTCATACCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGATGAACTTTGGAAAGGATGTCAGCACCTTGAAATATTTCACCATCTGTGGCTTACAAGAG；TGAACTTTGGAAAGGATGTCAGCACCTTGAAATATTTCACCATCTGTGGCTTACAAGAGGGCTATGAACCATTTGCCGTTAATACAAACAGGGATATTACCATGTGGCTGAGCAAGAG；GGCTATGAACCATTTGCCGTTAATACAAACAGGGATATTACCATGTGGCTGAGCAAGAGGCTTCCTCAGTTTCTTCAAGTTCCATCAAACCATGAACATATAGAGGTTTGCTTTTTCT；GCTTCCTCAGTTTCTTCAAGTTCCATCAAACCATGAACATATAGAGGTTTGCTTTTTCTTTAAAAATCAGGCCATTTCTAAAAAGCAGGAAAAGAATATCTTTATACAAAGGAACTTC；TAGAATCAGGAAATTGACAATGGTGATTGGAATGTGAACTATCGCTTCTTCGTTTGCTAGGTGACCAGAATAGACGGCACCATAGACAGTTCCCCATGTTTAAAGGTCACTCAGAAGT；GGTGACCAGAATAGACGGCACCATAGACAGTTCCCCATGTTTAAAGGTCACTCAGAAGTCTTTTGGTTCTCAGAACAGCAACACTGATATCATGTTTTATCGCCTGAGCATGCCGATC；CTTTTGGTTCTCAGAACAGCAACACTGATATCATGTTTTATCGCCTGAGCATGCCGATCGAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGAGGGCTCCCTGGGGCTGGCCTTTT；GAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGAGGGCTCCCTGGGGCTGGCCTTTTTGGGCCCAAGAATGACTTGGAAGATTATGATGCTGATTCTGACTTTGAGGTTCTGATGA；TGGGCCCAAGAATGACTTGGAAGATTATGATGCTGATTCTGACTTTGAGGTTCTGATGAAGACAGCTCATGGCCATCTAGTGCCCGATCGTGTTGACAAAGACAAAGAAGCTACTAAA；AGACAGCTCATGGCCATCTAGTGCCCGATCGTGTTGACAAAGACAAAGAAGCTACTAAACCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAGCCCTCTCGTCTGAAACAAAG；CCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAGCCCTCTCGTCTGAAACAAAGGTTACTAATTTATACGCTGTGATTTTAAATTTGTAGTTATGTGAGGAAGGTTACAGTCC；TATTTGAAGTAGACAGAACATTTTAATGTTGCTTATTGTTAGTCCTCTGAAATATTTCAGATTTTTGCTTAGAAGAACAAAGCCAGATTACAGCACAAGCCATTCTGCAAGACTCACC；GATTTTTGCTTAGAAGAACAAAGCCAGATTACAGCACAAGCCATTCTGCAAGACTCACCGAAGATGTCCTTGCTGATGATCGGGATGACTATGATTTCTTGATGCAAACGTCCACGGT；GAAGATGTCCTTGCTGATGATCGGGATGACTATGATTTCTTGATGCAAACGTCCACGGTATGAGGTTGCAGCTTTTGTCGTTTATTTCTATCTGTCACTCATTATGTTTTACATCTCC；GATTGCAAATCCAAGTTTTGTTTTGTTTAGTTTTACTTTGCCAATATTTGGTTCTGCTATCTTCACAGTACTATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAATGTCTG；TCTTCACAGTACTATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAATGTCTGGGTGGGCTGGATTACATCAGATTTCCATCAGTATGACACAGGCTTTGACTTGGACAGAG；GGTGGGCTGGATTACATCAGATTTCCATCAGTATGACACAGGCTTTGACTTGGACAGAGTTCGCACAGTAACAGTTACTCTAGGAGATGAAAAAGGAAAAGTGCATGAAAGGTTAGTT；TTCGCACAGTAACAGTTACTCTAGGAGATGAAAAAGGAAAAGTGCATGAAAGGTTAGTTTTCCTCAATTTTTTGCAAGAATGACATGTGAAAAAAATATTGGTGAACCTAGCTATTCC；GCAAGATATACCTGCTTTCTCTTTTATCTGTGGTTGTACAAAGATAAAAATGTTCTTTTGAAATTCAGCATCAAACGCAGCAACTGCTATATGGTATGTGCGGGTGAGAGCATGAGCC；GAAATTCAGCATCAAACGCAGCAACTGCTATATGGTATGTGCGGGTGAGAGCATGAGCCCCGGGCAAGGACGCAACAATAATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCAGC；CCGGGCAAGGACGCAACAATAATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCAGCGGGCTGCTCACATTCATTGCCAATGGCAAGGAACTGAGCACATACTATCAGGTACGCGG；GGGCTGCTCACATTCATTGCCAATGGCAAGGAACTGAGCACATACTATCAGGTACGCGGTCAGTGATGATATCAGTCTTCTAGGGAGGAAGACTTCTTTCCCCCATTAAAGGAAAACA；TTGTTATAAAGAAAAACTTTTTCCCTTGTCTTGTTTCATTACTAACATTATTAAATTCATTAAATGTATTTCAGGTGGAACCGAGTACAAAATTATTTCCTGCGGTTTTTGCACAAGC；TTAAATGTATTTCAGGTGGAACCGAGTACAAAATTATTTCCTGCGGTTTTTGCACAAGCTACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATAAAGGTAATAAAACTTATTC；TACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATAAAGGTAATAAAACTTATTCCTGGTATTGTATTTGTATTTTTTCTATTAGGATATAGCATTGATTTATTCTGAAATGAA；ATTACTTTGTGAACCCCAAGGGATGTTCTACATTTATTCTTTTTCTGCCTCCCCATCCGCTAGAATGTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGCACAAGAACCCCGTGC；CTAGAATGTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGCACAAGAACCCCGTGCCGCAGTGCCCCCCGCGCCTCCACGTGCAGTTCCTGTCACACGTCCTGTGGAGCAGAATG；CGCAGTGCCCCCCGCGCCTCCACGTGCAGTTCCTGTCACACGTCCTGTGGAGCAGAATGCCCAACCAGTTTTTGAAGGTAGATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGT；CCCAACCAGTTTTTGAAGGTAGATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGTGCAGTGTTTGGATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGGAAAACAGGTCAG；GCAGTGTTTGGATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGGAAAACAGGTCAGCCCCAGTGAATCCCTGACATTCTGATTGGGACGCTTGGGATTAGCCTGCTGCCCGGGGC；TTCTCCTCTGATTCAGATTTTAAAAAATCATTCATTTCTAATCTTACTACCACTCTCCTCCCTTCTACAGATCTGTTGACATCTTAGAGTTGACAGAGCAGGAGGAATTGCTGAAATT；CCCTTCTACAGATCTGTTGACATCTTAGAGTTGACAGAGCAGGAGGAATTGCTGAAATTTCACTATCACACTCTCCGGCTCTACTCAGCCGTCTGTGCTCTTGGGAACCACCGGGTGG；TCACTATCACACTCTCCGGCTCTACTCAGCCGTCTGTGCTCTTGGGAACCACCGGGTGGCCCATGCCCTGTGCAGCCATGTGGATGAACCTCAGCTCCTCTATGCCATTGAGAACAAG；CCCATGCCCTGTGCAGCCATGTGGATGAACCTCAGCTCCTCTATGCCATTGAGAACAAGTACATGCCTGGTTTGCTGCGTGCTGGCTACTATGACCTGCTGATTGACATCCACCTGAG；TACATGCCTGGTTTGCTGCGTGCTGGCTACTATGACCTGCTGATTGACATCCACCTGAGCTCCTATGCCACTGCCAGGCTCATGATGAACAACGAGTACATTGTCCCCATGACGGAGG；CTCCTATGCCACTGCCAGGCTCATGATGAACAACGAGTACATTGTCCCCATGACGGAGGAGACGAAGAGCATCACCCTGTTCCCTGATGAGAACAAAAAACACGGCCTTCCAGGGATC；AGACGAAGAGCATCACCCTGTTCCCTGATGAGAACAAAAAACACGGCCTTCCAGGGATCGGCCTCAGCACCTCCCTCAGGCCACGGATGCAGTTTTCCTCCCCCAGTTTTGTAAGCAT；GGCCTCAGCACCTCCCTCAGGCCACGGATGCAGTTTTCCTCCCCCAGTTTTGTAAGCATTAGTAATGAATGTTACCAGTACAGTCCAGAGTTCCCACTGGACATCCTCAAGTCCAAAA；TAGTAATGAATGTTACCAGTACAGTCCAGAGTTCCCACTGGACATCCTCAAGTCCAAAACCATACAGATGCTGACAGAAGCTGTTAAAGAGGGCAGTCTTCATGCCCGGGACCCAGTT；CCATACAGATGCTGACAGAAGCTGTTAAAGAGGGCAGTCTTCATGCCCGGGACCCAGTTGGAGGGACTACTGAATTCCTCTTTGTACCTCTCATCAAGCTTTTCTATACCCTGCTGAT；GGAGGGACTACTGAATTCCTCTTTGTACCTCTCATCAAGCTTTTCTATACCCTGCTGATCATGGGCATCTTTCACAACGAGGACTTGAAGCACATCTTGCAGTTGATTGAGCCCAGTG；CATGGGCATCTTTCACAACGAGGACTTGAAGCACATCTTGCAGTTGATTGAGCCCAGTGTGTTTAAAGAAGCTGCCACTCCGGAGGAGGAGAGTGACACGCTGGAGAAAGAGCTCAGT；TGTTTAAAGAAGCTGCCACTCCGGAGGAGGAGAGTGACACGCTGGAGAAAGAGCTCAGTGTGGACGATGCAAAGCTGCAAGGAGCTGGTGAGGAAGAAGCCAAGGGGGGCAAGCGGCC；GTGGACGATGCAAAGCTGCAAGGAGCTGGTGAGGAAGAAGCCAAGGGGGGCAAGCGGCCCAAGGAAGGCCTGCTCCAAATGAAACTGCCAGAGCCAGTTAAATTGCAGGTAATCAGAA；CAAGGAAGGCCTGCTCCAAATGAAACTGCCAGAGCCAGTTAAATTGCAGGTAATCAGAACAAGAGACTTGAGTGAATTTCAGAATTGCTAAGCATTAAGGTATTAGAACATGCCTTTG；TACCACAGATTATGATTTCATACACATTATTAAAGGATTTAGAAATTAAATTTGGTGTCTTTTTAATGGTCTCTTAGATGTGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCG；TTTTTAATGGTCTCTTAGATGTGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCGGCACCGGATAGAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTAAGCTCCAAGACA；GCACCGGATAGAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTAAGCTCCAAGACAATCAACGTTTCCGATACAACGAAGTCATGCAAGCCTTAAACATGTCAGCTGCACTCACA；ATCAACGTTTCCGATACAACGAAGTCATGCAAGCCTTAAACATGTCAGCTGCACTCACAGCCAGGAAGACAAAGGAATTTAGATCACCACCTCAAGAACAGGTACAGAAATGAAATGA；GCCAGGAAGACAAAGGAATTTAGATCACCACCTCAAGAACAGGTACAGAAATGAAATGAAAATTCTTCGTATTTATGTTGGCTTTTAGTCATTCAGGATCTCTGCCTTGCAAAATTAT；CCATTCTTGAATTCACCTTTCTTTTCTTCCTCCTTCTTCCTCTTTCTTGTTTTTCAAACTTTCAGATCAATATGCTTCTCAATTTTAAGGATGACAAAAGTGAATGTCCATGTCCAGA；TTTCAGATCAATATGCTTCTCAATTTTAAGGATGACAAAAGTGAATGTCCATGTCCAGAAGAAATTCGTGACCAACTATTGGATTTCCATGAAGATTTGATGACACATTGTGGTAAGG；AGAAATTCGTGACCAACTATTGGATTTCCATGAAGATTTGATGACACATTGTGGTAAGGTCTTTTTGATTAAAAGCTTTTATTAATTGTATGTTTTTAATCCATATATCCTGAGACGA；TTACAAGGCCTCAGAATTATTTGCCCAAGTGTATTCTTTAAATATTTTTTTCTGCCTCTCTGTTTTTTTATACTAGGAATTGAGCTGGATGAAGATGGGTCTCTGGATGGAAACAGTG；CTGTTTTTTTATACTAGGAATTGAGCTGGATGAAGATGGGTCTCTGGATGGAAACAGTGATTTAACAATTAGAGGGCGTCTGCTATCCCTGGTAGAAAAGGTGACATATCTGAAGAAG；ATTTAACAATTAGAGGGCGTCTGCTATCCCTGGTAGAAAAGGTGACATATCTGAAGAAGAAGCAAGCAGAAAAACCAGTTGAGAGTGACTCCAAAAAGTCCTGTAAGCAGTATGAGAG；AAGCAAGCAGAAAAACCAGTTGAGAGTGACTCCAAAAAGTCCTGTAAGCAGTATGAGAGTGCACTGGCAGAATGACCCAACTGCTGACACTTAACTCATCCTTTGAACGAATGTTTTA；GACTTGAAATGTCCAACTGATTTGTCTTCTCTTATTTTTCTTTTAAAAAATATCCATAATGACTTTGCAGCCACTCTGCAGCAGCTGATTTCTGAGACCATGGTCCGATGGGCTCAGG；TGACTTTGCAGCCACTCTGCAGCAGCTGATTTCTGAGACCATGGTCCGATGGGCTCAGGAGTCTGTCATTGAAGACCCCGAGCTGGTGAGGGCCATGTTTGTGTTGCTCCATCGGCAG；AGTCTGTCATTGAAGACCCCGAGCTGGTGAGGGCCATGTTTGTGTTGCTCCATCGGCAGTATGACGGCATTGGGGGTCTTGTTCGGGCCCTGCCAAAGACCTACACGATAAATGGTGT；TATGACGGCATTGGGGGTCTTGTTCGGGCCCTGCCAAAGACCTACACGATAAATGGTGTGTCCGTGGAGGACACCATCAACCTGCTGGCATCCCTTGGTCAGATTCGGTCCCTGCTGA；GTCCGTGGAGGACACCATCAACCTGCTGGCATCCCTTGGTCAGATTCGGTCCCTGCTGAGTGTGAGAATGGGCAAAGAAGAAGAGAAGCTCATGATTCGTGGATTAGGGTAAATTATT；GTGTGAGAATGGGCAAAGAAGAAGAGAAGCTCATGATTCGTGGATTAGGGTAAATTATTTAACTACTACAACCCTTTGTCTCGTAAATGTTTTCTAATTGTTATACCTATAGAGCAGT；TTGGTTAACTATTTAGATGTTGCTCTGAGCTTTACCCCATACGTCCATTGTCCTTTCTAGGGATATTATGAATAACAAAGTGTTTTACCAGCACCCTAATCTCATGAGGGCACTGGGG；GGGATATTATGAATAACAAAGTGTTTTACCAGCACCCTAATCTCATGAGGGCACTGGGGATGCACGAGACTGTGATGGAGGTCATGGTGAACGTCCTTGGAGGTGGAGAGTCCAAGGT；ATGCACGAGACTGTGATGGAGGTCATGGTGAACGTCCTTGGAGGTGGAGAGTCCAAGGTAACGTCTTTGATTCCTGAGATGCTATTTAGTATCATCTCCTGGAGTATATAGATTGATA；GATGTGATTGAGACCTCAACGTATGAACTCAATTTTATAAAGGTCGTTTGCTTTCAGCAGCTAATGACATGCTTTATCTGTAGGAAATCACCTTTCCCAAGATGGTGGCCAACTGTTG；GCTAATGACATGCTTTATCTGTAGGAAATCACCTTTCCCAAGATGGTGGCCAACTGTTGCCGTTTTCTCTGTTACTTCTGTCGTATAAGTAGGCAGAATCAAAAAGCTATGTTTGATC；CCGTTTTCTCTGTTACTTCTGTCGTATAAGTAGGCAGAATCAAAAAGCTATGTTTGATCATCTCAGTTATTTACTGGAAAACAGCAGTGTTGGTCTTGGTAAGTAAATGACTTTTATT；ATCTCAGTTATTTACTGGAAAACAGCAGTGTTGGTCTTGGTAAGTAAATGACTTTTATTTCATCTTTAAGGTTGAAATAATATAATATTACATTTAAAAAGCAAACGTTTTGTTAAA；TTTTTGTATGGAGTTTATAGTTACAGCACGATCCAGGTTATATTTCATCTTCATTTGAATTAATAGCCTCCCCAGCTATGAGAGGTTCAACACCACTGGATGTGGCTGCAGCTTCGGT；TTAATAGCCTCCCCAGCTATGAGAGGTTCAACACCACTGGATGTGGCTGCAGCTTCGGTGATGGATAATAATGAACTAGCATTAGCTCTGCGTGAGCCGGATCTAGAAAAGGTGAGCA；GATGGATAATAATGAACTAGCATTAGCTCTGCGTGAGCCGGATCTAGAAAAGGTGAGCAATGTTCCTGCCCTGTGTGTTTGTCTGAATTATGCTTTTTCACGGTTTTCTCAATATTTT；TGTCATTTATTGTATCCAATGTAAGCATCTAATGAGTTTTCAGCCAAGGGATAACTCTTTGTTAATCATGTTGTTTGCAGGTAGTTCGTTATTTGGCTGGTTGTGGACTGCAAAGTTG；TGTTAATCATGTTGTTTGCAGGTAGTTCGTTATTTGGCTGGTTGTGGACTGCAAAGTTGCCAGATGCTGGTGTCTAAGGGCTATCCAGACATTGGGTGGAACCCAGTTGAAGGAGAGA；CCAGATGCTGGTGTCTAAGGGCTATCCAGACATTGGGTGGAACCCAGTTGAAGGAGAGAGATATCTTGACTTTCTTAGATTTGCTGTCTTCTGTAATGGTAGGACTTGATTTCTTGAG；GATATCTTGACTTTCTTAGATTTGCTGTCTTCTGTAATGGTAGGACTTGATTTCTTGAGGTCTTTTGAGTTATCATTAAAACTGCATAGAGATATAATAAGGATTCATCTCAGCACTT；AGGAAATGATTAGTATAACATTTATTTGTTCAGAACTTCCATATAATCATATTTGTTTACTTATCTTCCCCATTCTACTTTAGGGGAGAGTGTGGAGGAAAATGCAAATGTCGTGGTG；CTTATCTTCCCCATTCTACTTTAGGGGAGAGTGTGGAGGAAAATGCAAATGTCGTGGTGAGATTGCTCATTCGGAGGCCTGAGTGTTTTGGTCCTGCTTTGAGAGGAGAAGGTGGGAA；AGATTGCTCATTCGGAGGCCTGAGTGTTTTGGTCCTGCTTTGAGAGGAGAAGGTGGGAATGGGCTTCTTGCAGCAATGGAAGAAGCCATCAAAATCGCCGAGGATCCTTCCCGAGATG；TGGGCTTCTTGCAGCAATGGAAGAAGCCATCAAAATCGCCGAGGATCCTTCCCGAGATGGTCCCTCACCAAATAGCGGATCCAGTAAAACACTGTAGGTCTAATATACACACCCTCAC；GTCCCTCACCAAATAGCGGATCCAGTAAAACACTGTAGGTCTAATATACACACCCTCACGAGTGATCCATACTACTTGATGTGAAATTTTATAAAATATATTCTGCATCCTATGAATT；TGTAATAAACATGAAATGTCAGTTATCCCATTTGCTTTCTCTTTCTTTTGAAACATTCATGAAAGTGACACAGAGGAGGAGGAAGATGACACTATCCACATGGGGAACGCGATCATGA；TGAAAGTGACACAGAGGAGGAGGAAGATGACACTATCCACATGGGGAACGCGATCATGACCTTCTATTCAGCTTTGATTGACCTCTTGGGACGCTGTGCTCCTGAGATGCATGTGAGT；CCTTCTATTCAGCTTTGATTGACCTCTTGGGACGCTGTGCTCCTGAGATGCATGTGAGTTTCTGGGAGTTCAGGAGCAGCAATCCTGATTTCTCTGTGTTAAGACATCTATAGCTGTC；CTTGGATTCCAATACTTCAGATTTCCTAGACAGAATTGTAACATTGATGTCACAAAGTTGTTCTAATGTTTTTTTTTCCCCTGTATAGTTGATTCATGCCGGGAAGGGAGAAGCCATC；GTTCTAATGTTTTTTTTTCCCCTGTATAGTTGATTCATGCCGGGAAGGGAGAAGCCATCAGAATTAGGTCCATTTTGAGATCCCTCATTCCCCTGGGAGATTTGGTGGGCGTTATCAG；AGAATTAGGTCCATTTTGAGATCCCTCATTCCCCTGGGAGATTTGGTGGGCGTTATCAGCATCGCTTTTCAGATGCCAACAATAGCCAAAGGTAAGGCCAACTTCAATTTGTCCTAAT；CATCGCTTTTCAGATGCCAACAATAGCCAAAGGTAAGGCCAACTTCAATTTGTCCTAATTCAGTAGGATGTTGGATGACATCATGTTCTAAAGAATGTTTTCCGTACTCAACATCCCA；ATTTGTAATCTATCCTGTATATGACACAGCCATTGACACCAAAATTCACTTCTCTCTTTTAGATGGGAATGTGGTGGAACCTGACATGTCTGCGGGGTTTTGCCCAGATCACAAGGCA；TAGATGGGAATGTGGTGGAACCTGACATGTCTGCGGGGTTTTGCCCAGATCACAAGGCAGCCATGGTTTTATTCCTTGACAGGGTCTATGGGATTGAGGTTCAAGACTTCCTCCTCCA；GCCATGGTTTTATTCCTTGACAGGGTCTATGGGATTGAGGTTCAAGACTTCCTCCTCCATCTTCTTGAGGTTGGCTTTCTGCCAGATCTCCGGGCGGCTGCTTCTTTAGATACGGTGA；TCTTCTTGAGGTTGGCTTTCTGCCAGATCTCCGGGCGGCTGCTTCTTTAGATACGGTGAGATTGGAGCGATGGACTTCCTCCTCTCTTGACTCTTCACTCTGTGCCTTATGATGTTCT；GTTAATCCCTTTGAAGATTATCTACTGCCAAACACAAATGGCCTTCTACTCTCTGATTCTTTTTCAGGCAGCTTTGAGTGCTACAGACATGGCCTTGGCCCTCAATCGGTACCTTTGC；TTTTTCAGGCAGCTTTGAGTGCTACAGACATGGCCTTGGCCCTCAATCGGTACCTTTGCACAGCCGTCTTGCCATTGTTAACAAGATGTGCTCCTCTCTTTGCTGGCACAGAGCACCA；ACAGCCGTCTTGCCATTGTTAACAAGATGTGCTCCTCTCTTTGCTGGCACAGAGCACCACGCTTCTCTCATTGACTCATTACTTCATACTGTGTATAGACTTTCTAAGGGCTGTTCAC；CGCTTCTCTCATTGACTCATTACTTCATACTGTGTATAGACTTTCTAAGGGCTGTTCACTTACCAAAGCTCAGCGGGATTCCATAGAAGTTTGTTTACTCTCTATTTGTGGGTGAGTG；TTACCAAAGCTCAGCGGGATTCCATAGAAGTTTGTTTACTCTCTATTTGTGGGTGAGTGGATAACAAATTCTATTCCGGCTTCTTCTTTAAAAAACAGAATTTACAATGTGGCCTTTG；TTATTCTAATGAATGATCTACTTAGTTTAGAAACATTTCTTGGCATTATGAACATTAGCTTTGTTCCAACAGACAACTGAGACCTTCTATGATGCAGCACTTACTCAGAAGATTAGTA；TTTGTTCCAACAGACAACTGAGACCTTCTATGATGCAGCACTTACTCAGAAGATTAGTATTTGATGTTCCATTATTAAATGAACACGCAAAGATGCCTCTTAAAGTAAGTATAGGAAA；TTTGATGTTCCATTATTAAATGAACACGCAAAGATGCCTCTTAAAGTAAGTATAGGAAATGTTTGTAGATATTTGATTACTGGCTTCTCTGACTTTATTTTCTATGACAACATATACA；TGTGATATGAGGAGAAATGAAAAAAAAATATAAAAGGTTTTGATAGCTCATTGCTTTTATAATTGTTTTCCCACATAGCTGCTGACAAATCATTATGAAAGATGCTGGAAATATTACT；TAATTGTTTTCCCACATAGCTGCTGACAAATCATTATGAAAGATGCTGGAAATATTACTGCCTGCCTGGAGGGTGGGGAAACTTTGGTGCTGCCTCAGAAGAAGAACTTCATTTATCA；GCCTGCCTGGAGGGTGGGGAAACTTTGGTGCTGCCTCAGAAGAAGAACTTCATTTATCAAGAAAGTTGTTCTGGGGCATTTTTGATGCCCTGTCTCAAAAGGTAATTTAATGGTTTGT；AGAAAGTTGTTCTGGGGCATTTTTGATGCCCTGTCTCAAAAGGTAATTTAATGGTTTGTGGGTTTGTTTGTATCAATAAAATGGTATAGAGCCACACATTCTTAGTAAGATAGTATTC；CTGATGATCATGCTGACAACTTTTGCCATATAGTAATTTTTTTTTTTGGTCCTCCATTTTTCCCAGAAATATGAACAAGAACTTTTCAAACTGGCACTGCCTTGCCTGAGTGCAGTTG；TTCCCAGAAATATGAACAAGAACTTTTCAAACTGGCACTGCCTTGCCTGAGTGCAGTTGCGGGAGCTTTGCCTCCAGACTACATGGAGTCAAATTATGTCAGTATGATGGAAAAACAG；CGGGAGCTTTGCCTCCAGACTACATGGAGTCAAATTATGTCAGTATGATGGAAAAACAGTCATCAATGGATTCTGAAGGGAACTTTAACCCACAACCTGTTGATACCTCAAAGTATGG；TCATCAATGGATTCTGAAGGGAACTTTAACCCACAACCTGTTGATACCTCAAAGTATGGACTCTTTCTATTGCAGCAGATTTTTATTGTAAATGATGTGTGAAGTCTGAAATTGAATA；AGCTGTGAGTAAATTATTAATATGATTTCCTGTAAATTCTGTGAAAATCAAGCTCTTTTGTCTTTACTTTTCTCATAGTATTACAATTCCTGAGAAATTGGAATACTTCATTAACAAA；GTCTTTACTTTTCTCATAGTATTACAATTCCTGAGAAATTGGAATACTTCATTAACAAATATGCAGAACACTCCCATGACAAATGGTCAATGGACAAGGTAAAAAGAGTATTACATTC；TATGCAGAACACTCCCATGACAAATGGTCAATGGACAAGGTAAAAAGAGTATTACATTCTAATTCAGTAGTCATTATTAATGACTGGTCACTGTTCAAATATTTCTGACCATGACAGT；TAAACACCTGCATATCTACAATCTCTAAAATTAACACGTGTAAAACAATTTTTAATGTTTGCCTTTTTTTAAGTTGGCAAATGGATGGATTTATGGAGAAATATATTCAGACTCTTCT；TGCCTTTTTTTAAGTTGGCAAATGGATGGATTTATGGAGAAATATATTCAGACTCTTCTAAGGTTCAGCCATTAATGAAGCCATATAAGCTATTGTCTGAAAAGGTAAGGATTTTTTG；AAGGTTCAGCCATTAATGAAGCCATATAAGCTATTGTCTGAAAAGGTAAGGATTTTTTGTTTGTTTTAGTTTGTAAAGTTTTTATTCTTTTGAAAAATGTGTTTTTTGGTTATATTTT；ATTTTAGAGCAAAGCGTTACTTAACATTTTTATTTACATTCATAATATATCTGTTGTTTCTTGTTTTTTCTTCTCTAGGAAAAAGAAATTTATCGCTGGCCAATCAAAGAATCTTTAA；CTTGTTTTTTCTTCTCTAGGAAAAAGAAATTTATCGCTGGCCAATCAAAGAATCTTTAAAAACTATGCTGGCTTGGGGCTGGAGAATTGAAAGAACTCGGGAGGGAGACAGCATGGCC；AAACTATGCTGGCTTGGGGCTGGAGAATTGAAAGAACTCGGGAGGGAGACAGCATGGCCCTTTACAACCGGACTCGTCGTATTTCTCAGACAAGCCAGGTAAGAATTCATCACGGTGA；CTTTACAACCGGACTCGTCGTATTTCTCAGACAAGCCAGGTAAGAATTCATCACGGTGATGAATCAACTGTTTATGTTATGGATTAAATAATTTTTTAAATTTAATTATTGAGTTTTT；CCATATTTTTAAAGTATAAGTTAAGTCTCTCTTCACAAGGTTTTTAATGAGGCACTGTTTTTTCACACAAATGATCTAGGTTTCTGTGGACGCTGCCCATGGTTACAGTCCCCGGGCC；TTTTCACACAAATGATCTAGGTTTCTGTGGACGCTGCCCATGGTTACAGTCCCCGGGCCATTGACATGAGCAATGTTACACTATCTAGAGACCTGCATGTAAGTACTATTAACTTTTA；ATTGACATGAGCAATGTTACACTATCTAGAGACCTGCATGTAAGTACTATTAACTTTTAAAAATAGTCTCCAAATTTAATTTTTAAGAAGCATAATGTAATGCTTTCCTGCATATATT；CGGTATCTAATATTATATATTAGAAAGCAATATTATCCTTTTTTACTTATTGAAACGATAAATATTTTTGTTCATTTAAGGCTATGGCAGAAATGATGGCTGAAAACTACCATAATAT；AAATATTTTTGTTCATTTAAGGCTATGGCAGAAATGATGGCTGAAAACTACCATAATATATGGGCAAAGAAAAAGAAAATGGAGTTGGAGTCCAAAGGTAATATTTTCTAAAAACGTT；ATGGGCAAAGAAAAAGAAAATGGAGTTGGAGTCCAAAGGTAATATTTTCTAAAAACGTTTATTAAAAAATAATCTGAGCTCAATTCCATGAGTGTATGGATGAAGTCGTCTTCAGCAC；ATAGTGTGGTCCAATTATATATCTGTGTCTCATCTCAGATTCTTTTCAAATTACTATGCTGTGTTCTTGTCCTGACATACTCTTAGGAGGAGGAAACCATCCTCTGCTGGTGCCCTAT；TGTGTTCTTGTCCTGACATACTCTTAGGAGGAGGAAACCATCCTCTGCTGGTGCCCTATGATACACTGACAGCCAAAGAGAAAGCCAAGGATAGAGAAAAAGCACAGGACATCCTCAA；GATACACTGACAGCCAAAGAGAAAGCCAAGGATAGAGAAAAAGCACAGGACATCCTCAAGTTCTTGCAGATCAATGGATATGCTGTATCCAGGTAAAAGTACACATACCCTAAGTACA；GTTCTTGCAGATCAATGGATATGCTGTATCCAGGTAAAAGTACACATACCCTAAGTACACACTCTTTTCACAAGAGTGAATATTTAAATATCTCCATCATATTTAAAGCTGAAAATGA；TTTTACCTTCTAAGAGGCTTTGTACAAATTGCTTTCCCATTTTCATTTTTGCTCTTCCAGAGGATTTAAGGACCTGGAACTGGACACGCCTTCTATTGAGAAACGATTTGCCTATAGT；GAGGATTTAAGGACCTGGAACTGGACACGCCTTCTATTGAGAAACGATTTGCCTATAGTTTCCTCCAACAACTCATTCGCTATGTGGATGAAGCCCATCAGTATATCCTGGAGTTTGG；TTCCTCCAACAACTCATTCGCTATGTGGATGAAGCCCATCAGTATATCCTGGAGTTTGGTAGGTACCATAGTCCCATTGCTAATAGCCCAGTGTTTGTTGTTTTTAATGTTTACAACA；CAATGCTTTCTAACCTTTGCATTATGGATGAATATCTTGCAATGTTTCCAGTGCAGCATTTACCTAAAAACTCTTCAAATCTACAGATGGTGGCAGCAGAGGCAAAGGAGAACATTTC；TTACCTAAAAACTCTTCAAATCTACAGATGGTGGCAGCAGAGGCAAAGGAGAACATTTCCCTTATGAACAAGAAATCAAGTTCTTTGCAAAAGTACAGTATACAATCTATCTTGTTTT；CCTTATGAACAAGAAATCAAGTTCTTTGCAAAAGTACAGTATACAATCTATCTTGTTTTTGCTTCAATATGTTTGTTTACATACCCTACTCATTAGATCGTTGCCCTTTTCAGAACAT；AACTCTGACTGCTCCAAAGCCTCAGCTCCCATTCATCCCCTGAAAGATTCCACTACGTAGATCTGTCTTCTTTTCCTTTCTTTCAGGTCGTTCTTCCTTTAATTGATCAGTATTTCAA；GATCTGTCTTCTTTTCCTTTCTTTCAGGTCGTTCTTCCTTTAATTGATCAGTATTTCAAAAACCATCGTTTATACTTCTTATCTGCAGCAAGCAGACCTCTCTGCTCTGGAGGACATG；AAACCATCGTTTATACTTCTTATCTGCAGCAAGCAGACCTCTCTGCTCTGGAGGACATGCTTCCAACAAAGAGAAAGAAATGGTGACTAGGTAAACAGCTATAAAAATAAGCACTGTT；CTTCCAACAAAGAGAAAGAAATGGTGACTAGGTAAACAGCTATAAAAATAAGCACTGTTGTATGACTTAGGTGTATATGCAGTTGCAAAGAAAACCTGAGGACCTTGAAGTGGGGCTG；TTTTGTTTTTCTTTTGTCTTCAGCCTATTCTGCAAACTTGGAGTTCTTGTCAGGCATAGGATTTCACTATTTGGTAAGGAGACCCTTGAAAAAATACAAGCATGGCCATCACTTGGTT；GATTTCACTATTTGGTAAGGAGACCCTTGAAAAAATACAAGCATGGCCATCACTTGGTTTTCTTTGCCATTTTTGCACTGTGTTGTGTGCTGCTATGTTGCATGGATGCATGTTTGCA；CTAATTTTTCTAGCACAAATATTGGTAGAAAAGAAGAACATTGAGAAATTCTCAGGGCAATTTATACAGCATTTTGTTTCCTCTTTAGGCAATGATGCAACATCAATTGTCAACTGTC；ATTTATACAGCATTTTGTTTCCTCTTTAGGCAATGATGCAACATCAATTGTCAACTGTCTTCATATTTTGGGTCAGACTTTGGATGCAAGGTAAATGGATACATTTTTACCTAAATAA；TTCATATTTTGGGTCAGACTTTGGATGCAAGGTAAATGGATACATTTTTACCTAAATAAATTACTATAATAATGATACATGTATATATATAAGAATATTAAGAAGGACCCAGTGTCTG；AATAAACATCATAAGAGAACCACAATTCATTTATATTTCATTTGTTCCTGTTGGAAGATACGAGTCCTCCCTTATTTACTTTCTAGGACAGTGATGAAGACTGGCCTGGAGAGTGTTA；ACGAGTCCTCCCTTATTTACTTTCTAGGACAGTGATGAAGACTGGCCTGGAGAGTGTTAAAAGTGCACTCAGAGCTTTTCTGGACAACGCTGCAGAGGATCTGGAGAAGACCATGGAA；AAAGTGCACTCAGAGCTTTTCTGGACAACGCTGCAGAGGATCTGGAGAAGACCATGGAAAACCTCAAGCAGGGCCAGTTCACTCACACCCGAAACCAGCCCAAAGGGGTTACTCAGAT；AACCTCAAGCAGGGCCAGTTCACTCACACCCGAAACCAGCCCAAAGGGGTTACTCAGATTATCAATTACACCACAGTGGCCCTGCTGCCAATGCTGTCTTCATTATTTGAACATATTG；TATCAATTACACCACAGTGGCCCTGCTGCCAATGCTGTCTTCATTATTTGAACATATTGGCCAGCATCAGTTCGGAGAAGACCTAATATGTATGTAAATTTATATCTTGGAGTTTTTT；GCCAGCATCAGTTCGGAGAAGACCTAATATGTATGTAAATTTATATCTTGGAGTTTTTTTTTTTTTAATCGAAATACCCTGTAGTACAATCAAAAACAGTAATAGCCACATCTGGGTT；TACATAGCTTAAGCTTTCTCAGGACAATGTATAAATAAGTGGGTTTTTCTTTCAAGTGAGATTCTCTTTTTCCTTAGTGGAAGATGTCCAGGTGTCTTGTTATAGAATTCTGACTAGC；GATTCTCTTTTTCCTTAGTGGAAGATGTCCAGGTGTCTTGTTATAGAATTCTGACTAGCTTATATGCTTTGGGAACCAGCAAGAGTATTTACGTGGAGAGGTAAGAATGTTTAAAGTT；TTATATGCTTTGGGAACCAGCAAGAGTATTTACGTGGAGAGGTAAGAATGTTTAAAGTTTAACTTTGTATTAATTGCTGCTTCAAGTTTTATAACTATTTATTTCAAGAATCTTCATT；AGGTTAAATTTGCTAATTGTAATATGACTTTTTTAGTTACTCACTTGGAAGACCTTAAAACATAAGCATTTTCCACTTATAGGCAACGTTCTGCATTAGGAGAATGTCTAGCTGCCTT；ACATAAGCATTTTCCACTTATAGGCAACGTTCTGCATTAGGAGAATGTCTAGCTGCCTTTGCTGGTGCTTTTCCTGTAGCATTTTTGGAAACTCATCTGGACAAACATAATATTTACT；TGCTGGTGCTTTTCCTGTAGCATTTTTGGAAACTCATCTGGACAAACATAATATTTACTCCATCTACAATACCAAGTCTTCACGAGAAAGAGCAGGTAACACAGAAACATGTGCAGTG；CCATCTACAATACCAAGTCTTCACGAGAAAGAGCAGGTAACACAGAAACATGTGCAGTGCTTTGAGATATGAAGCTAAAACTTGATATTTATCATATTGTCCAATAGTGATTTTTAAT；AGTTGCCTGTGGAAATCCGCCATATCATCTCAGTACTTTCTTTGAATATCATCCATTTTTATATGTACTTCTCCAGCTCTCAGTTTGCCAACTAATGTGGAAGATGTTTGTCCAAACA；TATATGTACTTCTCCAGCTCTCAGTTTGCCAACTAATGTGGAAGATGTTTGTCCAAACATACCGTCTTTGGAGAAACTCATGGAAGAAATCGTGGAATTAGCCGAGTCCGGCATTCGC；TACCGTCTTTGGAGAAACTCATGGAAGAAATCGTGGAATTAGCCGAGTCCGGCATTCGCTACACTCAAATGCCACATGTCATGGAAGTCATACTGCCCATGCTTTGCAGCTACATGTC；TACACTCAAATGCCACATGTCATGGAAGTCATACTGCCCATGCTTTGCAGCTACATGTCTCGTTGGTGGGAGCATGGACCTGAGAACAATCCAGAACGGGCCGAGATGTGCTGCACAG；TCGTTGGTGGGAGCATGGACCTGAGAACAATCCAGAACGGGCCGAGATGTGCTGCACAGCCCTGAACTCAGAGCACATGAACACACTTCTAGGGAACATATTGAAAATCATATATAAT；CCCTGAACTCAGAGCACATGAACACACTTCTAGGGAACATATTGAAAATCATATATAATAACTTGGGGATTGATGAGGGAGCCTGGATGAAGAGGCTAGCAGGTAAGAACTGGAAGAA；AACTTGGGGATTGATGAGGGAGCCTGGATGAAGAGGCTAGCAGGTAAGAACTGGAAGAAGACATTGTACCCCTGAAATCTGTTTTATTTCCAAAAGAATTTTAAATACATAAACTAGA；AATTATGTTACAATTGTAATTACAATCTATCATCATGTTAATGAATGGTTTTACAGAGCAGAATACTAATGTCTGTCTTTAAACAGTGTTTTCCCAGCCTATAATAAATAAAGTGAAA；AGAATACTAATGTCTGTCTTTAAACAGTGTTTTCCCAGCCTATAATAAATAAAGTGAAACCTCAGCTCTTGAAAACTCATTTCTTGCCGTTAATGGAGAAACTCAAGAAAAAGGCAGC；CCTCAGCTCTTGAAAACTCATTTCTTGCCGTTAATGGAGAAACTCAAGAAAAAGGCAGCTACGGTGGTGTCTGAGGAAGACCACCTGAAAGCTGAGGCCAGGGGGGACATGTCGGAGG；TACGGTGGTGTCTGAGGAAGACCACCTGAAAGCTGAGGCCAGGGGGGACATGTCGGAGGCAGAACTCCTCATCCTAGATGAGTTCACCACACTGGCCAGAGATCTCTATGCCTTCTAC；CAGAACTCCTCATCCTAGATGAGTTCACCACACTGGCCAGAGATCTCTATGCCTTCTACCCTCTCTTGATTAGATTTGTGGACTATAACAGGTATGATCAAAAGTAATTTAGTAATTT；CCTCTCTTGATTAGATTTGTGGACTATAACAGGTATGATCAAAAGTAATTTAGTAATTTCTCCAATTCGGTCATAACGTTTCTTGGCTCACATGTCCTTGTTCAATCGCTTCATTCAC；GGGGGATGGTTTTTTTTTTTTAAATTAACTTTAAGGAGTAGCTGAGAAACCACTTTATTTATTATGTGATCCAGGGCAAAGTGGCTAAAGGAGCCTAACCCAGAAGCAGAGGAGCTCT；TATTATGTGATCCAGGGCAAAGTGGCTAAAGGAGCCTAACCCAGAAGCAGAGGAGCTCTTCCGCATGGTGGCTGAAGTGTTTATCTACTGGTCGAAGTCCCATGTGAGTGTGAAAATA；TCCGCATGGTGGCTGAAGTGTTTATCTACTGGTCGAAGTCCCATGTGAGTGTGAAAATATTGATAGATCACGCCTACTGTTTGTAGGCACCTGCTTACTTGCCTCCTAGGTTTCATGT；GTTCTGTGTAACCTCTAATTACAAAGACTTCTTTAAGTGGTTTTAACTGAAATTTCCTTTGCAACTTCTCAGAATTTCAAAAGAGAAGAGCAGAACTTCGTTGTACAGAATGAAATCA；TGCAACTTCTCAGAATTTCAAAAGAGAAGAGCAGAACTTCGTTGTACAGAATGAAATCAACAATATGTCTTTCCTTATTACTGATACCAAGTCAAAGATGTCAAAGGTATTACTATAA；ACAATATGTCTTTCCTTATTACTGATACCAAGTCAAAGATGTCAAAGGTATTACTATAAACTGTTTCACTGTTCTGGAAAATATCTGAATGTGACTTTCATGAATTGACTTTTTTTTT；CATAGTGGTTCTACATGTGAGAAAAGCAGGTTCAGATCCCAGCACTTCTCTTTGTTCCATAGGCAGCTGTTTCTGATCAGGAAAGGAAGAAAATGAAGCGCAAAGGAGATCGGTATTC；TAGGCAGCTGTTTCTGATCAGGAAAGGAAGAAAATGAAGCGCAAAGGAGATCGGTATTCCATGCAGACCTCTCTGATTGTAGCAGCTCTGAAGCGGTTACTGCCCATTGGGTTGAACA；CATGCAGACCTCTCTGATTGTAGCAGCTCTGAAGCGGTTACTGCCCATTGGGTTGAACATCTGTGCCCCTGGGGACCAGGAGCTCATTGCTCTGGCCAAAAATCGATTTAGCCTGGTA；TCTGTGCCCCTGGGGACCAGGAGCTCATTGCTCTGGCCAAAAATCGATTTAGCCTGGTAAGTCTCCTTTTCATCCCAGCGGTAATGATCATCTGACCTCCAGACTCTCAGTGTTTGAT；TTTCAAAAAAGGTTTGGATTGTTTCTATTGACTTGTGACAGTTGATGCAATAGAAGACTCCTTTTAGGTAACATATATTTCTTGACAGAAAGATACCGAGGATGAAGTACGAGATATA；CCTTTTAGGTAACATATATTTCTTGACAGAAAGATACCGAGGATGAAGTACGAGATATAATCCGCAGCAATATTCATTTACAAGGCAAGGTAAGCCAAATTTTATTCTTAAGCCACAT；ATCCGCAGCAATATTCATTTACAAGGCAAGGTAAGCCAAATTTTATTCTTAAGCCACATTTACTACCTATACATTAGTTAATCTCTCTTTAAAATAATACTATAAATAATGTTACTTT；TGGACTCTTCCTATCTTTAGATTGTAACCTTGTTTTTAGATTCCCATCTTCCCATTGTAACCTTTTCCTTTTTTCTGCAGTTGGAGGATCCTGCTATTAGATGGCAAATGGCTCTTTA；ACCTTTTCCTTTTTTCTGCAGTTGGAGGATCCTGCTATTAGATGGCAAATGGCTCTTTACAAAGACTTACCAAACAGGACTGATGATACCTCAGATCCAGAGAAGACGGTAGAAAGAG；CAAAGACTTACCAAACAGGACTGATGATACCTCAGATCCAGAGAAGACGGTAGAAAGAGTATTGGATATAGCAAATGTGCTTTTTCATCTTGAACAGGTCAGGCTTTGTGTCAATTCA；TATTGGATATAGCAAATGTGCTTTTTCATCTTGAACAGGTCAGGCTTTGTGTCAATTCAATCATATTTGCCTTAGCCACATACAAATATTTTAAAAAGAGAATGTGTGTTAATTTGTT；CTCTTTACTGCAAAGGATAATAAATGTAGTTTTACTTTTTTAGCTAACATAACATTTTTATTTCTTTCAGAAGTCTAAACGTGTGGGTCGGAGACATTACTGTCTGGGAAGTACAGTG；ATTTCTTTCAGAAGTCTAAACGTGTGGGTCGGAGACATTACTGTCTGGGAAGTACAGTGCTCAATGGCCTAGAGATTACTAATTAATTTAGGTTTATATGTTGGGATTTTTTCTTTCT；TATTTATTTGTTTTTGAAGGTAGTTTGGGGTGTAAATATTTATTTGTGTCATTCTACCTCAGGTGGAACATCCTCAGAGATCTAAAAAGGCTGTATGGCATAAACTACTGTCCAAGCA；CAGGTGGAACATCCTCAGAGATCTAAAAAGGCTGTATGGCATAAACTACTGTCCAAGCAGAGGAAAAGGGCTGTTGTAGCCTGCTTCCGGATGGCCCCCTTATATAATCTGCCAAGGT；GAGGAAAAGGGCTGTTGTAGCCTGCTTCCGGATGGCCCCCTTATATAATCTGCCAAGGTCGGAATTACTTTATTTTTTGTAATAGATCAATGTTATTTTTTCCTAGTAAGTGACAGGT；AAGCACTACTCAATACAATTTCAACTTATTTTCTAAACACCCTTTTTCTGAAATTGTGCTTACCTTTCAGGCATCGGGCTGTCAATCTCTTTCTTCAGGGATATGAAAAGTCTTGGAT；TTACCTTTCAGGCATCGGGCTGTCAATCTCTTTCTTCAGGGATATGAAAAGTCTTGGATTGAAACAGAAGAACATTACTTTGAAGATAAACTGATAGAAGATTTAGCAGTATGTTTTT；TGAAACAGAAGAACATTACTTTGAAGATAAACTGATAGAAGATTTAGCAGTATGTTTTTAGTGGGGCTCTAAGATGAAAGAGGGTCTAGGCTTGGTGCAGCAATGTTGGCGTGAGCAG；GTGCTTTTGGATTTGAGTGAACATTTTTTTTTAATGTGACATTTTATAAATTTGACTTTTTTGCAGAAACCTGGGGCTGAACCTCCAGAAGAAGATGAAGGCACTAAGAGAGTTGATC；TTTGCAGAAACCTGGGGCTGAACCTCCAGAAGAAGATGAAGGCACTAAGAGAGTTGATCCTCTACATCAGCTGATCCTTCTGTTTAGTCGGACAGCTTTAACAGAGAAATGGTATGGT；CTCTACATCAGCTGATCCTTCTGTTTAGTCGGACAGCTTTAACAGAGAAATGGTATGGTTGGGAGGGTTCCTATGAGACATAGGAGGAGCAAATAAAGACACCCGTGTCTGAGTATTC；ATACGTGTGCATGTGCCTAGCCTTCTGCTTAAACACTGATGTTTTCTTCTTGCTTTCCCCAGCAAACTGGAGGAAGATTTTTTATATATGGCCTATGCAGATATTATGGCAAAGGTAA；CAGCAAACTGGAGGAAGATTTTTTATATATGGCCTATGCAGATATTATGGCAAAGGTAAATAAGTATCCTTCCTGATTTTCATGTTTAATTTTAATAAAGGGAAGTAACTTTCATCTG；TTTGCACTTTCTAAAATCTCAACATATTCCTGTCTCCTTTTTTTTTTTTTTTAAATATACAGAGTTGTCATGATGAGGAAGATGACGATGGTGAAGAGGAAGTGAAGAGTTTTGAAGT；CAGAGTTGTCATGATGAGGAAGATGACGATGGTGAAGAGGAAGTGAAGAGTTTTGAAGTAAGATGGATCTTTCTGGATTTGCCTTTCTTTCTATCTTGAAACATTGTTTCATAGCTTA；ATATGGTCTGTAGAAATCTGTTGTGCTTACTGATACCCTCAACATAAATGGTTGGGATTTGTGTTCAGGAAAAAGAAATGGAAAAGCAAAAGCTTCTATACCAGCAAGCCCGACTCCA；TGTGTTCAGGAAAAAGAAATGGAAAAGCAAAAGCTTCTATACCAGCAAGCCCGACTCCACGATCGTGGCGCGGCTGAGATGGTGCTACAGACAATCAGTGCCAGCAAAGGTAAGGTTC；CGATCGTGGCGCGGCTGAGATGGTGCTACAGACAATCAGTGCCAGCAAAGGTAAGGTTCCTTGAGTTCCCCTCACGAGTGTCTGTTCTTCAGATTTCCTCGTTGCTCTCAAGGTCCTC；AGTGCAGCATTGGAGGTAGAATAGGTTAATATAGAAGGCGAAATGATATAAGGAACACTACTTTTTTATATTTCTTAGGTGAAACTGGACCAATGGTAGCAGCTACTCTGAAACTTGG；ACTTTTTTATATTTCTTAGGTGAAACTGGACCAATGGTAGCAGCTACTCTGAAACTTGGAATTGCTATTTTAAATGGTGGGAACTCCACAGTACAGCAGGTAACAGCTTCCAGTCATT；AATTGCTATTTTAAATGGTGGGAACTCCACAGTACAGCAGGTAACAGCTTCCAGTCATTCATATAATGTACTTTTCAGACAAATGGACCATATAGTAAAGAACTATTTGTTGTAAAAT；AGCCTGTTTTGGTTGTTTATTTATTTAACAAACAATAAGATTTTTGTTCAGTGGCCACGTGGTTTCTATAATTCCCATAGAAAATGCTTGACTACCTCAAGGAGAAAAAGGATGTGGG；TGGTTTCTATAATTCCCATAGAAAATGCTTGACTACCTCAAGGAGAAAAAGGATGTGGGCTTCTTTCAGAGCCTGGCCGGCCTGATGCAGTCATGTAGGTAAGGACTCACTTCCTTCT；CTTCTTTCAGAGCCTGGCCGGCCTGATGCAGTCATGTAGGTAAGGACTCACTTCCTTCTTGGGGGTTCTACTCAGTGGTTGTATTTTTTCGAAGCATTTGTTTCTTACTCTGACGATA；GGTGTTTAGATGTTTGCTCTCCTGAGCAAAGAAAATGTTCTATTAGTCCTCTAAATGTTTTTTTTTCCCTTGTTATTATAGTGTCCTTGACCTAAATGCATTTGAGCGACAAAACAAA；TTTTTTTCCCTTGTTATTATAGTGTCCTTGACCTAAATGCATTTGAGCGACAAAACAAAGCTGAAGGTCTTGGGATGGTGACAGAGGAAGGATCAGGTATTAATGACTTACATTAAAA；GCTGAAGGTCTTGGGATGGTGACAGAGGAAGGATCAGGTATTAATGACTTACATTAAAAGGATCACCTGTCTCCCTTCCCTCCCTGAAACGAGTCAATTATCAATTACCTTTCAAGTA；TTGTATGGAGGTGGGGACAGAAAGGGAGCGGCAGGCTGGGGTGGCTGGTAATGTTTGATCCCTCTGGATTTCCCACAGGAGAAAAGGTTCTGCAGGACGATGAGTTCACCTGTGACCT；CCCTCTGGATTTCCCACAGGAGAAAAGGTTCTGCAGGACGATGAGTTCACCTGTGACCTCTTCCGATTCCTGCAACTACTCTGTGAGGGACACAACTCAGGTTTGTGAGTCCCCGGAA；CTTCCGATTCCTGCAACTACTCTGTGAGGGACACAACTCAGGTTTGTGAGTCCCCGGAACTTCTGATGATACTAAGGCATAAATAATGTTTTCAAGCCAGTAATAACAAGAGCCTGTT；GCCTTTGGAGTTCTTAGAATGACTCAACTTGAACTTCTGAGCAAGCATTAATAACATTTTTTTATCTTGCATAGATTTTCAGAATTATCTGAGAACTCAGACTGGCAATAATACAACT；TTTTATCTTGCATAGATTTTCAGAATTATCTGAGAACTCAGACTGGCAATAATACAACTGTCAACATAATTATCTCCACTGTAGACTACCTACTGAGAGTTCAGGTATGTTGCTTTCC；GTCAACATAATTATCTCCACTGTAGACTACCTACTGAGAGTTCAGGTATGTTGCTTTCCATATTAGTAACAAATTAAAAGGGTTGGTATGTTGAAACAATACGGCAGAGTTTTAATGT；TCAGGCATAAAGTCCAAGACTGGTTAGTCAATGGTAACTTTAGAATGTGACTTGATAATAAATAATATCATCTCTATTTCCCAGGAATCAATTAGTGACTTTTATTGGTATTACTCTG；AAATAATATCATCTCTATTTCCCAGGAATCAATTAGTGACTTTTATTGGTATTACTCTGGGAAAGATGTTATTGATGAACAAGGACAACGGAATTTCTCCAAAGCTATCCAAGTGGCA；GGAAAGATGTTATTGATGAACAAGGACAACGGAATTTCTCCAAAGCTATCCAAGTGGCAAAACAAGTCTTTAACACTCTTACAGAGTATATTCAGGTAAACATTTAAACATGGCTGCT；AAACAAGTCTTTAACACTCTTACAGAGTATATTCAGGTAAACATTTAAACATGGCTGCTATCTGTAGCACTGAACTCCATAGAAAAATGCAGTATATCTAGAGTAGTTTCCATATCTC；ATTGTACAGTTTGTTTTGGCAAATAAATTATGAGGAATAATTGCCGTTTGTCTGTTTATGCTCCAGGGTCCTTGCACTGGGAATCAACAGAGTTTGGCACACAGCAGGCTGTGGGATG；GCTCCAGGGTCCTTGCACTGGGAATCAACAGAGTTTGGCACACAGCAGGCTGTGGGATGCTGTGGTCGGCTTTCTTCATGTGTTTGCCCATATGCAGATGAAGCTGTCGCAGGTAAAC；CTGTGGTCGGCTTTCTTCATGTGTTTGCCCATATGCAGATGAAGCTGTCGCAGGTAAACTAACTAACTGCCTTCCTCTCTCTTAAATGACAAACTGGAGACTGTAATCATCAGCAAAT；TTTTTGTGAGAATAAGTATGATGTTCCTGCTGCATAGTTTTCTTGTATTATCTCAAATGCAATGTTCATATTTTCAGGATTCCAGTCAAATTGAGCTATTAAAAGAATTAATGGATCT；CAATGTTCATATTTTCAGGATTCCAGTCAAATTGAGCTATTAAAAGAATTAATGGATCTGCAGAAGGATATGGTGGTCATGTTGCTGTCCATGTTAGAAGGTAGTTTTGATTTATACT；GCAGAAGGATATGGTGGTCATGTTGCTGTCCATGTTAGAAGGTAGTTTTGATTTATACTTTTAAATTCTCTTTATTATCTTATTTAAAGGATCAGCATGGGCTTATGGAATCAGAGTG；ATGTTATTAAAGATCTACATTGTTATCTTCTGTATGATCACTGATTTTGTTAGTTTATTTTAAACAAATGCAACTGCTTTACCACCAGGTAATGTTGTTAATGGAACGATTGGCAAAC；TTAAACAAATGCAACTGCTTTACCACCAGGTAATGTTGTTAATGGAACGATTGGCAAACAGATGGTGGATATGCTTGTGGAATCTTCCAACAACGTGGAGATGATTCTCAAATTTTTT；AGATGGTGGATATGCTTGTGGAATCTTCCAACAACGTGGAGATGATTCTCAAATTTTTTGACATGTTCTTAAAACTAAAGGATTTGACGTCGTCTGATACTTTTAAAGAATATGACCC；GACATGTTCTTAAAACTAAAGGATTTGACGTCGTCTGATACTTTTAAAGAATATGACCCCGATGGCAAGGGAGTCATTTCCAAGAGGGACTTCCACAAAGCGATGGAGAGCCATAAGC；CGATGGCAAGGGAGTCATTTCCAAGAGGGACTTCCACAAAGCGATGGAGAGCCATAAGCACTACACGCAGTCAGAAACGGAATTTCTTTTGTCTTGTGCGGAGACGGATGAGAATGAA；ACTACACGCAGTCAGAAACGGAATTTCTTTTGTCTTGTGCGGAGACGGATGAGAATGAAACCCTCGACTACGAAGAGTTCGTCAAACGCTTCCACGAACCTGCGAAGGACATCGGCTT；ACCCTCGACTACGAAGAGTTCGTCAAACGCTTCCACGAACCTGCGAAGGACATCGGCTTCAACGTCGCCGTCCTTCTGACAAACCTCTCTGAGCACATGCCCAACGATACCCGACTTC；CAACGTCGCCGTCCTTCTGACAAACCTCTCTGAGCACATGCCCAACGATACCCGACTTCAGACTTTTCTGGAATTAGCAGAGAGCGTCCTGAATTATTTCCAGCCCTTTCTGGGCCGC；AGACTTTTCTGGAATTAGCAGAGAGCGTCCTGAATTATTTCCAGCCCTTTCTGGGCCGCATCGAAATCATGGGAAGCGCCAAACGCATCGAGAGGGTCTATTTTGAAATCAGTGAGTC；ATCGAAATCATGGGAAGCGCCAAACGCATCGAGAGGGTCTATTTTGAAATCAGTGAGTCCAGCCGAACCCAGTGGGAGAAGCCCCAGGTCAAGGAGTCCAAAAGACAGTTCATATTTG；CAGCCGAACCCAGTGGGAGAAGCCCCAGGTCAAGGAGTCCAAAAGACAGTTCATATTTGACGTGGTCAACGAAGGCGGAGAGAAAGAGAAGATGGAACTCTTTGTGAACTTCTGCGAG；ACGTGGTCAACGAAGGCGGAGAGAAAGAGAAGATGGAACTCTTTGTGAACTTCTGCGAGGACACCATCTTTGAAATGCAGCTGGCGGCTCAGATCTCGGAGTCGGACTTGAACGAGAG；GACACCATCTTTGAAATGCAGCTGGCGGCTCAGATCTCGGAGTCGGACTTGAACGAGAGGTCAGCGAATAAGGAAGAAAGCGAGAAGGAGAGGCCGGAAGAGCAGGGGCCGAGGATGG；GTCAGCGAATAAGGAAGAAAGCGAGAAGGAGAGGCCGGAAGAGCAGGGGCCGAGGATGGCTTTCTTCTCCATTCTGACGGTCAGGTCGGCCCTGTTTGCGCTCAGGTACAATATCTTG；CTTTCTTCTCCATTCTGACGGTCAGGTCGGCCCTGTTTGCGCTCAGGTACAATATCTTGACCCTTATGCGAATGCTCAGTCTGAAGAGCCTGAAGAAGCAGATGAAAAAAGTAAAAAA；ACCCTTATGCGAATGCTCAGTCTGAAGAGCCTGAAGAAGCAGATGAAAAAAGTAAAAAAGATGACCGTGAAGGACATGGTCACGGCCTTCTTTTCATCCTACTGGAGTATTTTCATGA；GATGACCGTGAAGGACATGGTCACGGCCTTCTTTTCATCCTACTGGAGTATTTTCATGACCCTCTTGCACTTCGTGGCCAGCGTTTTCAGAGGCTTTTTCCGCATCATTTGCAGCCTG；CCCTCTTGCACTTCGTGGCCAGCGTTTTCAGAGGCTTTTTCCGCATCATTTGCAGCCTGCTGCTTGGGGGAAGCCTCGTCGAAGGTGCTAAAAAGATCAAAGTTGCAGAACTGTTAGC；CTGCTTGGGGGAAGCCTCGTCGAAGGTGCTAAAAAGATCAAAGTTGCAGAACTGTTAGCCAACATGCCAGACCCCACTCAGGATGAGGTTAGAGGAGATGGGGAGGAGGGAGAGAGGA；CAACATGCCAGACCCCACTCAGGATGAGGTTAGAGGAGATGGGGAGGAGGGAGAGAGGAAACCCCTGGAAGCCGCCCTGCCCTCCGAGGATCTGACCGACTTAAAGGAGCTGACAGAG；AACCCCTGGAAGCCGCCCTGCCCTCCGAGGATCTGACCGACTTAAAGGAGCTGACAGAGGAAAGTGACCTTCTTTCGGACATCTTTGGCCTGGATCTGAAGAGAGAAGGAGGACAGTA；GAAAGTGACCTTCTTTCGGACATCTTTGGCCTGGATCTGAAGAGAGAAGGAGGACAGTACAAACTGATTCCTCATAATCCAAATGCTGGGCTCAGTGACCTCATGAGCAACCCAGTCC；CAAACTGATTCCTCATAATCCAAATGCTGGGCTCAGTGACCTCATGAGCAACCCAGTCCCCATGCCTGAGGTGCAGGAAAAATTTCAGGTAATTTATCTCTAAGTCACAGCAGCATTC；CCATGCCTGAGGTGCAGGAAAAATTTCAGGTAATTTATCTCTAAGTCACAGCAGCATTCTCTCTGGACTTCAGGTGGGTATAATAAATGATCATTAGACCAGGTTTCATGCTAGTGCC；TTGACACATGGTCACATGGCTCCCTCAATTCATTCAAAGGTGATGGGTAATCCTGGTTTTCTTTTCCCCATTGACTCATTCAAGGAACAGAAGGCAAAAGAAGAAGAAAAGGAAGAAA；TCTTTTCCCCATTGACTCATTCAAGGAACAGAAGGCAAAAGAAGAAGAAAAGGAAGAAAAAGAAGAAACCAAATCTGAACCTGAAAAAGCCGAGTATGTATAGTTTGCATATACTTTT；AAGAAGAAACCAAATCTGAACCTGAAAAAGCCGAGTATGTATAGTTTGCATATACTTTTCCTTCGTTTCAGTTTGTCATTACATCTCTTTTTCTTGTACTCTGTCTTTGGGAGCTGCA；GGGTAATTTTCCACAACACCCGTTTAGTTCTTTAGTTTCTGGAGAGCTTATGTTTTGTTTGTTTGTTTTCATAGGGGAGAAGATGGAGAAAAAGAAGAGAAAGCCAAGGAAGACAAGG；TGTTTGTTTTCATAGGGGAGAAGATGGAGAAAAAGAAGAGAAAGCCAAGGAAGACAAGGGCAAACAAAAGTTGAGGCAGCTTCACACACACAGATACGGAGAACCAGAAGTGCCAGAG；GCAAACAAAAGTTGAGGCAGCTTCACACACACAGATACGGAGAACCAGAAGTGCCAGAGTCAGCATTCTGGAAGAAAATCATAGCATATCAACAGAAACTTCTAGTAAGATGTTTTAG；TCAGCATTCTGGAAGAAAATCATAGCATATCAACAGAAACTTCTAGTAAGATGTTTTAGAATGAATATTGTTACTGATATAGTGCAATACCGTAATAATTTAGGCTCAGTAAATGTTT；TGCTTTATTTAAATTGACTGCAGGTTTCAAGCCTGTTGATTCAGTGACCTTTTCATAATGTTTTTCACCCTCAGAACTATTTTGCTCGCAACTTTTACAACATGAGAATGTTAGCCTT；GTTTTTCACCCTCAGAACTATTTTGCTCGCAACTTTTACAACATGAGAATGTTAGCCTTATTTGTCGCATTTGCTATCAATTTCATCTTGCTCTTTTATAAGGTACGTACATCTCACT；ATTTGTCGCATTTGCTATCAATTTCATCTTGCTCTTTTATAAGGTACGTACATCTCACTGTTTTAATTACTGGTATAAAACTCCAAATAGAAATGAATGTAAAGATTTCACGATGAAC；TGAAAAGGCTGTATTTCTTTTGTCTTTTGCTTGCAATGGTATCTTAGATGCAGCAAACTGACTCTACTTTAAATGCTTTGAATCAGGTCTCCACTTCTTCTGTGGTTGAAGGAAAGGA；GACTCTACTTTAAATGCTTTGAATCAGGTCTCCACTTCTTCTGTGGTTGAAGGAAAGGAGCTCCCCACGAGAAGTTCAAGTGAAAATGCCAAAGTGACAAGCCTGGACAGCAGCTCCC；GCTCCCCACGAGAAGTTCAAGTGAAAATGCCAAAGTGACAAGCCTGGACAGCAGCTCCCATAGAATCATCGCAGTTCACTATGTACTAGAGGAGAGCAGCGGCTACATGGAGCCCACG；ATAGAATCATCGCAGTTCACTATGTACTAGAGGAGAGCAGCGGCTACATGGAGCCCACGTTGCGTATCTTAGCTATTCTGCACACGGTCATTTCTTTCTTCTGCATCATTGGATACTA；TTGCGTATCTTAGCTATTCTGCACACGGTCATTTCTTTCTTCTGCATCATTGGATACTACTGCTTGAAAGTAAGATAGTAAGGCACCAAGGTACCTGTGTGTGTGTGTGTGTGTGTG；AAAGCTGTTTTGTAAAGATAGTGACCACAAGATATGCCAGTAAATCTAAACTAATTTTAACGTATTTATTTTTCCTATGTAGGTCCCATTGGTTATTTTTAAGCGAGAAAAGGAAGTG；ACGTATTTATTTTTCCTATGTAGGTCCCATTGGTTATTTTTAAGCGAGAAAAGGAAGTGGCACGGAAATTGGAATTTGATGGGCTTTATATTACAGAACAGCCTTCAGAAGATGATAT；GCACGGAAATTGGAATTTGATGGGCTTTATATTACAGAACAGCCTTCAGAAGATGATATTAAAGGCCAGTGGGATAGACTCGTAATCAACACACAGTGAGTAAATAATTATATGAGAC；TAAAGGCCAGTGGGATAGACTCGTAATCAACACACAGTGAGTAAATAATTATATGAGACTTTCTGCACTCAAAAATTTCAGACATGAAAATATTTGGTTGGAGTTCCTGCAGATTTGT；AAATGATATGTTATTATTTGTCATTAAAAATAATACTATTTACTTCTATGCTTTTGTATATTTTAGGTCATTTCCCAACAACTACTGGGACAAATTTGTTAAAAGAAAGGTAATATTA；ATTTTAGGTCATTTCCCAACAACTACTGGGACAAATTTGTTAAAAGAAAGGTAATATTACTTGGAATCCTCTACATTTTTCTTAAAGCACAGTTTAGATTTTTATTTGATGTGATTCA；AATTAGATGTTTTATACACACATATAGATGATGTTACTTAATGGTTGAAGCCAACAAAATGCTTTTTCTCATACCCCAAGGTTATGGATAAATATGGAGAGTTCTACGGCCGAGACAG；TGCTTTTTCTCATACCCCAAGGTTATGGATAAATATGGAGAGTTCTACGGCCGAGACAGAATCAGTGAATTACTTGGCATGGACAAGGCAGCTCTGGACTTCAGTGATGCCAGAGAAA；AATCAGTGAATTACTTGGCATGGACAAGGCAGCTCTGGACTTCAGTGATGCCAGAGAAAAGAAGAAGCCAAAGAAAGACAGCTCCTTATCAGCTGTGTAAGTGTTACTTCGGCTCTAT；AGAAGAAGCCAAAGAAAGACAGCTCCTTATCAGCTGTGTAAGTGTTACTTCGGCTCTATCCTACAGACTTAGATTGAAAGGGGAAAACATTAATACATTTTTAAACTTGTGCATTGAT；TTGAATGTGAAGGCCGTCAGGCTCTCGCAAGCCTATGAGTCTTTGGTTAATGTGCATAACTACGCATTTTTTTTTTTTGTCATTGCAGACTGAACTCCATTGATGTGAAGTATCAGAT；CTACGCATTTTTTTTTTTTGTCATTGCAGACTGAACTCCATTGATGTGAAGTATCAGATGTGGAAACTAGGAGTCGTTTTCACTGACAACGTAAGCCTACTTCATTATCACAAAAGAA；GTGGAAACTAGGAGTCGTTTTCACTGACAACGTAAGCCTACTTCATTATCACAAAAGAAAATGCACTCTGATTAGATAAGACTGTGGGAGTTCTGCAGATGGAAGGCTGGTTATTTAG；TTTTGCTTAACCCATAACAATAGTCATGCGTTCTGTTTTCTGACATGTTCTTTCCCCCCGTTTTGTCTTAATAGTCCTTCCTCTACCTAGCCTGGTATATGACTATGTCTGTTCTTGG；GTTTTGTCTTAATAGTCCTTCCTCTACCTAGCCTGGTATATGACTATGTCTGTTCTTGGACACTATAACAACTTTTTTTTTGCCGCTCACCTTCTCGACATTGCTATGGGATTCAAGA；ACACTATAACAACTTTTTTTTTGCCGCTCACCTTCTCGACATTGCTATGGGATTCAAGACATTAAGAACCATCTTGTCCTCAGTAACTCACAATGGCAAACAGGTAAACAGTTTATCT；CATTAAGAACCATCTTGTCCTCAGTAACTCACAATGGCAAACAGGTAAACAGTTTATCTTTTTCCTCCCTTGCAGAAAATAAAAAAGCAACAAATAAAACAAAGAAAAATAAAACTAC；CTCGCCGCCCATGTAGATGTCACGTGTCAATTGTATGTCCTACATTTCTAATACCTGGTCCTTGTCACATTGTTTTCCAGCTCGTATTAACCGTTGGCTTATTAGCTGTTGTTGTATA；CCTTGTCACATTGTTTTCCAGCTCGTATTAACCGTTGGCTTATTAGCTGTTGTTGTATACCTATACACTGTGGTGGCATTCAATTTTTTCCGAAAATTCTACAATAAAAGTGAAGATG；CCTATACACTGTGGTGGCATTCAATTTTTTCCGAAAATTCTACAATAAAAGTGAAGATGGTGATACACCAGATATGAAATGTGACGATATGCTAACAGTAAGTTCATAACCTTTGATC；GTGATACACCAGATATGAAATGTGACGATATGCTAACAGTAAGTTCATAACCTTTGATCTCACATAAACAAAAATGTCTCCTGCTTCTGCAGTCTAAGTAATTGTGTATTTATTCTCT；AACTCGGGTTTGTCGAGAAAAAAAAATGGGTAATGTCCCTCCAAGAAGTGATACCATGTCTTTTTTCCAGTGCTATATGTTCCACATGTATGTTGGAGTTCGTGCTGGAGGAGGGATC；CTTTTTTCCAGTGCTATATGTTCCACATGTATGTTGGAGTTCGTGCTGGAGGAGGGATCGGGGATGAAATCGAAGACCCAGCAGGAGATGAATATGAGATCTATCGAATCATCTTTGA；GGGGATGAAATCGAAGACCCAGCAGGAGATGAATATGAGATCTATCGAATCATCTTTGACATCACTTTCTTCTTCTTTGTTATTGTCATTCTCTTGGCCATAATACAAGGTAAGTATC；CATCACTTTCTTCTTCTTTGTTATTGTCATTCTCTTGGCCATAATACAAGGTAAGTATCCTCCTCACTGAAGCTGATGAACATCTAGAATTTGAGCCACATGTTGCTGAAGTTAATAT；TCTCCCCTTTCCCTGGGGGGATTAGCCAAGGAACTGAATTATTCATTGCTTGATAAAGATTAAATTGTGTTTTTATTTAACACCAGGTCTAATTATTGATGCTTTTGGAGAACTAAGA；TTAAATTGTGTTTTTATTTAACACCAGGTCTAATTATTGATGCTTTTGGAGAACTAAGAGACCAACAGGAACAAGTCAAAGAAGACATGGAGGTAAGCTTCTCCATTCATGACTCAGC；GACCAACAGGAACAAGTCAAAGAAGACATGGAGGTAAGCTTCTCCATTCATGACTCAGCTTCTTTGTTGTCCTGGGCCCTCGTTTTCCTCACTACCTTTATCAATAGAATCATGAATG；GGCGAGTTGTGTTTTCCTTTTGTTTTGCTTTCTGAACTCTGACGTTAATATTTCCCTTTGTTTTCTAGACCAAATGCTTCATCTGTGGGATAGGCAATGATTACTTCGACACAGTGCC；GTTTTCTAGACCAAATGCTTCATCTGTGGGATAGGCAATGATTACTTCGACACAGTGCCACATGGCTTTGAAACCCACACTTTACAGGAGCACAACTTGGCTAATTACTTGTGAGTGT；ACATGGCTTTGAAACCCACACTTTACAGGAGCACAACTTGGCTAATTACTTGTGAGTGTGCCCGTTTCAGAATCTTCCACCTCTCCAGTAGACGCCACTGGTCCCTGCCCATCTCAGA；TGCCCTGTTTATCCTAATATTTCCATACCGTTCATTTCTGATCAGTTTCTCTGTATCTGTAGGTTTTTTCTGATGTATCTTATAAACAAAGATGAAACAGAACACACAGGACAGGTAG；TAGGTTTTTTCTGATGTATCTTATAAACAAAGATGAAACAGAACACACAGGACAGGTAGGTAAATTATTACATGTCATCTTCTGAAAGAAATGATAGAGAAGCTCTAAATATCAGAAC；CAGAATTGAGTTTCTACCTTATGTTTTGTTAGCACACACTTTGGGGAAAATGTTAATACATTTCCTTGACTTTTGCAGGAATCTTATGTCTGGAAGATGTATCAAGAAAGGTGTTGGG；ATTTCCTTGACTTTTGCAGGAATCTTATGTCTGGAAGATGTATCAAGAAAGGTGTTGGGAATTTTTCCCAGCAGGGGATTGCTTCCGGAAACAGTATGAAGACCAGCTAAATTAAACT；AATTTTTCCCAGCAGGGGATTGCTTCCGGAAACAGTATGAAGACCAGCTAAATTAAACTCAGACCCAATCACCTCTAAAAACCAAAACCCTACCCCTCTCTCTCCCTCTCTCAATTTC；
所述探针组3由如下核酸分子组成：
AAAATCCATCCATTGCAAGTCATGAGTGAATTTAGAGGAAGACAAATCTACTGAAACCACTATTCTACATATAGTGCCTATATGACAAAATCCTGCCTAACCACACTGCTTTATTTTA；TTAAAAGAGAGAAGCCAGAGGAAACGTGTGCAGCTGTCAGACGAGGCTCAGCAAAGAAAAAAATCCATCCATTGCAAGTCATGAGTGAATTTAGAGGAAGACAAATCTACTGAAACCA；TGGGCCCCGGCACCCAGTTGTGATGTGGAGAATGAAGGCTCCTGCAAAAAAACCCTTGATTAAAAGAGAGAAGCCAGAGGAAACGTGTGCAGCTGTCAGACGAGGCTCAGCAAAGAAA；CAAACAGTGAAAATGTCTTACATTGCCTCAACCAAGATCATCCGAATCCAGAGTCCTGCTGGGCCCCGGCACCCAGTTGTGATGTGGAGAATGAAGGCTCCTGCAAAAAAACCCTTGA；AGTTGGACAGTGTCACATCCCTGATCCAAGCAGCCAAAAATTTAATGAATGCTGTAGTGCAAACAGTGAAAATGTCTTACATTGCCTCAACCAAGATCATCCGAATCCAGAGTCCTGC；TTGGCAATAATTAACAAAACCTCCTGGAATAATAGCTCTTTTTTCTCTTTTTTCCCTACAGTTGGACAGTGTCACATCCCTGATCCAAGCAGCCAAAAATTTAATGAATGCTGTAGTG；AGATCCAGAACCTGGGAGGAGAGCTCATCATGTCAGCTGTGAGTACTGCCTAGCACTTACATGATCACAGGTGGAAGATGCTTGAAACAGAGTAACTACACCCTTGTTTACATGACCA；CCTGGAACAGATTAAGTTCTACTCCCACCAACTGAAAATCTGCAGTCAAGTTAAAGCTGAGATCCAGAACCTGGGAGGAGAGCTCATCATGTCAGCTGTGAGTACTGCCTAGCACTTA；TTATCTTTGATTCATATTTAGTGCCCAGATCCATCTTGTAAACAGGACTTGTTGGCCTACCTGGAACAGATTAAGTTCTACTCCCACCAACTGAAAATCTGCAGTCAAGTTAAAGCTG；TGTGAATACTGTATTTACTCACCTTGATCTAACTATTATTTATTCTGCTGTATCTATTTTTATCTTTGATTCATATTTAGTGCCCAGATCCATCTTGTAAACAGGACTTGTTGGCCTA；TATCAGAATCAGGATCAAGGATGGATGTCCTTGCTCGGCAGATTGCTAATCAGGTGAGTTACTTACAAGTGGACATCATAAAAGTTCATGCTAATTGCTCTTTGCCATTAGAACATTG；TTCCAGGGGCAAAGGACCACTAAAGCATACAACTGATGTGATCTATGCAGCGAAAATGATATCAGAATCAGGATCAAGGATGGATGTCCTTGCTCGGCAGATTGCTAATCAGGTGAGT；ACCATCGTAGCTAACATATATTTTCTCATGAACACCACAGCTAACATATATAAATTTTTTTCCAGGGGCAAAGGACCACTAAAGCATACAACTGATGTGATCTATGCAGCGAAAATGA；ATGATCATGATGGAGATGACAGACTTCACTAGGTAATTATGTGGAAAACGATGTGTAATATTCATAATGGCTGAAAATATTAGTCATATTAGTGAAACCTCAAGATTCTCTGAGTGTC；AGATTGAGATATGGGATGATACAAGCAACGACATCATTGTTCTGGCCAAGAACATGTGTATGATCATGATGGAGATGACAGACTTCACTAGGTAATTATGTGGAAAACGATGTGTAAT；AGAAAAGATTGCTGAGCAAGTTGCTGATTTCAAGAAAGTAAAGAGTAAGCTGGATGCTGAGATTGAGATATGGGATGATACAAGCAACGACATCATTGTTCTGGCCAAGAACATGTGT；TTTAACTCTAATTATCACATGTTTTAGGCTAAGATGACTCAACTGCCTGAGGCAGAAAAAGAAAAGATTGCTGAGCAAGTTGCTGATTTCAAGAAAGTAAAGAGTAAGCTGGATGCTG；TTATGAGTATCCTATAATATCTACTTATTCCTAAAATGCTTTTGACATAGTGGAATGATTTTAACTCTAATTATCACATGTTTTAGGCTAAGATGACTCAACTGCCTGAGGCAGAAAA；GGAAAACTGATAGGGTATGTCACTTCAACTGGTGGGAGAACCATGTACTGTGTCACTGAAGGCTGTGCCCTCCCTTTGTCAATCTAGGCAGCCTCTAATGGGTGGGACTCCTGGATCT；TGTTTCTGACCTTGAAGAGGAACACGAGGTCCGCAGTCACACCAGCATTCAGACCGAAGGGAAAACTGATAGGGTATGTCACTTCAACTGGTGGGAGAACCATGTACTGTGTCACTGA；TTACATTCCCACTAGCAATGTTTTGCTTTCTTTTTATAGACCCCAGAGGAACTGGAGGATGTTTCTGACCTTGAAGAGGAACACGAGGTCCGCAGTCACACCAGCATTCAGACCGAAG；TCTATGATACAATTCATGATATCAGATGTTCAGTCATGATGATTCGGGTAAGTTTGCTTTTCCTTCCATTGAATTATTGCAATGTTCTTCACCATCTGGAATGCCTGGGATGACTGCA；AAGCAAAAGCTCATTGAATGTGTTGGATGATAATCAATTTGTGGACATCTCAAAGAAGATCTATGATACAATTCATGATATCAGATGTTCAGTCATGATGATTCGGGTAAGTTTGCTT；TTTATTTTAACAGTAATTCCTGAATTTGTAACACAAGTGAATGTTGCCTTGGAAGCCTTAAGCAAAAGCTCATTGAATGTGTTGGATGATAATCAATTTGTGGACATCTCAAAGAAGA；TTTCCTGGAAACTACTGTATAAATCCAAAAATACAAAGAGGACAATCTTCTCCTTATTCTTTATTTTAACAGTAATTCCTGAATTTGTAACACAAGTGAATGTTGCCTTGGAAGCCTT；CGGAAGGTGTAATGAGAAATGTTAACTTCCTTACAAGTACTGGTAAGTCAGTTGCCAATAACAGCTGCACAATTTCTCTTATTTGAATCTACATAGCTACGAATATTCATACATGTGG；AGCAAGAGTTGCTCACATCGTCACGGGTGAAATGGACAGTTACGAGCCAGGGGCTTACACGGAAGGTGTAATGAGAAATGTTAACTTCCTTACAAGTACTGGTAAGTCAGTTGCCAAT；TTAAGAGACCAGGATGCTGATAATTTAGACCGTGCTGCGGGTGCTATCAGAGGCCGGGCAGCAAGAGTTGCTCACATCGTCACGGGTGAAATGGACAGTTACGAGCCAGGGGCTTACA；TGATTCATTTACTTACAGAAAGCCATATCTTGGAAGATGTCAACAAGTGTATCATAGCCTTAAGAGACCAGGATGCTGATAATTTAGACCGTGCTGCGGGTGCTATCAGAGGCCGGGC；ATAATTATAATATGCTAGATTTGTATGATTTTAAACACAGACACACGCAAAAACTAATTTGATTCATTTACTTACAGAAAGCCATATCTTGGAAGATGTCAACAAGTGTATCATAGCC；TACAAGCATTGATGACTTCCTTGCTGTATCTGGTATGTTTTTATTCTTTTAATTTGTTTATTTTCTCTTGTCAATTTTATAAAATAGAATAATACTGGGACAGGCATGGTGGCTCATG；GCGTACATGGGAGAATCATATACATGTCCTCACTGAAGCCGTAGATGACATTACAAGCATTGATGACTTCCTTGCTGTATCTGGTATGTTTTTATTCTTTTAATTTGTTTATTTTCTC；GGCTGCAAGACCCAAAAGTCAAGCGGTCAAAAACACCATGGAAATGTACAAGCGTACATGGGAGAATCATATACATGTCCTCACTGAAGCCGTAGATGACATTACAAGCATTGATGAC；GTAATTTTTTCAATCCTTATCTTTATAGATTATTAATGCTGCACTTGCTTTGGCTGCAAGACCCAAAAGTCAAGCGGTCAAAAACACCATGGAAATGTACAAGCGTACATGGGAGAAT；AAATTGTCAAAATTGCAGCCAATCATTTGGAAACCTTGTGTCCACAGGTATGACAACTAAGTTACTTTTTGTGTGTAAAATTATATATAATTCCTAATGCTTTTATGCATATGAAAAT；GATTGTATTTAAGGTGGCAAATCTTGCTTGTTCCATGTCAACAAATGAAGATGGAATTAAAATTGTCAAAATTGCAGCCAATCATTTGGAAACCTTGTGTCCACAGGTATGACAACTA；TGTTCAGTATAAGTGTTGCTGCATTTCCTTGCTAATCTAAAATAATTTCCATTATTTTGGATTGTATTTAAGGTGGCAAATCTTGCTTGTTCCATGTCAACAAATGAAGATGGAATTA；AAAGAATATGCTGCGATATTTCATGAACACACCAGCAGGCTTGTAGAGGTAAGCATGCTAGAACTGTAACTCACTAAAGTCCAGGAGAATGAGGCTCCCATTCTCCATTTATGGTTGA；CGACAGTCCCTCTTTTGGTTCTCATTGAAGCTGCTAAGAATGGCCGGGAAAAGGAAATAAAAGAATATGCTGCGATATTTCATGAACACACCAGCAGGCTTGTAGAGGTAAGCATGCT；CATTTCTTCTCAGCTCCGCAAGGCTATTATAGATCATGTGTCAGACTCTTTCCTGGATACGACAGTCCCTCTTTTGGTTCTCATTGAAGCTGCTAAGAATGGCCGGGAAAAGGAAATA；GATTGTAAGAAAAGGAAACACAGTGAACTATTTCCTGGAAAAAAAAAACCTGAATTTTTCATTTCTTCTCAGCTCCGCAAGGCTATTATAGATCATGTGTCAGACTCTTTCCTGGATA；TAGACAACATGTGTAAGAAGACAAGAGACCTTCGCAGACAGGTGAGGGAAGAGAGAGATATGGAGTCAGAAACATAGGGGCTAAATGAAACTGTTATTCATTGCAGGCATATTTGTTT；CGTTTTTTCTTCTTTGCAGGCTGGAAAAAAAGAAAGGAGTAATACCCTGAATATTGCTTTAGACAACATGTGTAAGAAGACAAGAGACCTTCGCAGACAGGTGAGGGAAGAGAGAGAT；AGGAAATTTAGAAAGCAAATTGCTAAGTGATAAAGATTAATTGATACCATTGCTTATGTCGTTTTTTCTTCTTTGCAGGCTGGAAAAAAAGAAAGGAGTAATACCCTGAATATTGCTT；TCGCCAGGCTCTTCAGGATCTGCTTTCAGAGTACATGAACAACGTAGGTGACTGGTTTGCCTTCCCATCCCTAGCCCCTCTTCCCTTGTACTTTGAATATAGGCTGAGATACTTTCCG；GATTCTTCATGTACGAGGGACTTACACCGAGAGCGGATTATCGCAGAATGCAACGCCATTCGCCAGGCTCTTCAGGATCTGCTTTCAGAGTACATGAACAACGTAGGTGACTGGTTTG；TACGACCATCACTAGAGAAACGCCTTGAAGCCATTATCAGTGGGGCTGCTCTGCTGGCGGATTCTTCATGTACGAGGGACTTACACCGAGAGCGGATTATCGCAGAATGCAACGCCAT；TGTGTTCTTCTCTTAGAATTTAATTGTCCTGAATCCACTCACAGTAACTGAGGAGGAAATACGACCATCACTAGAGAAACGCCTTGAAGCCATTATCAGTGGGGCTGCTCTGCTGGCG；AACAAAATAACATTTGTTTTTCATAAAAGTGAAATGCCATGGAGCTCTAACCATACAAATGTGTTCTTCTCTTAGAATTTAATTGTCCTGAATCCACTCACAGTAACTGAGGAGGAAA；ACCTCAGGCAGCAACCCTGGGAAGTGCCCTTGATGAGCTGGAGGTAAGTCGGGAGAAAGATAAAGTGTGATCTGATGTCCTAATACAGTAATAATAATAATAAAACAGAAGAAGATCC；GCTCTCAATGTAATTTCAAATGCTTCACAAGGGATCCAGAATATGACAACCCCACCAGAACCTCAGGCAGCAACCCTGGGAAGTGCCCTTGATGAGCTGGAGGTAAGTCGGGAGAAAG；ATTCTGATGTTGCTTCCCTCAAAGCAAGCAAGGACACAGTTTGTGAAGAAATTCAGAATGCTCTCAATGTAATTTCAAATGCTTCACAAGGGATCCAGAATATGACAACCCCACCAGA；AGCTTCACTGAAGGAGAACTCTCCCCTCTTGCATTCAATTTGTTCAGCTTGTTTGGAGCATTCTGATGTTGCTTCCCTCAAAGCAAGCAAGGACACAGTTTGTGAAGAAATTCAGAAT；TATTTACCTTCTCAGGACTTAAAATCTCCAAATCAGAGAGATGAAATTGCAGGAGCCCGAGCTTCACTGAAGGAGAACTCTCCCCTCTTGCATTCAATTTGTTCAGCTTGTTTGGAGC；AAAGAAGCTTTTTAATTTAAGTCTTTCTCCCATAACCCATTGTAAGATACCACTCTTTTTATTTACCTTCTCAGGACTTAAAATCTCCAAATCAGAGAGATGAAATTGCAGGAGCCCG；TTTGGATTATTTAGCCTTCAAACGTCAGCAGGTAGGAGTCAGAGCTCTCCTTGGTGGAGGAGATGAACACTTTAGGCTTCCTGCCATCCTGCCTGTCAGAGGTGCAGGTGGGTCTGAG；GTTGCCAACAAATCTGACCTCCAGAAAACCTACCAGAAGCTTGGGAAGGAGCTGGAAAATTTGGATTATTTAGCCTTCAAACGTCAGCAGGTAGGAGTCAGAGCTCTCCTTGGTGGAG；TAATGATCTACTTTTGTTTTCAATTTCAGTTTCAAAGGACATTTGAGTCTCTCAAAAATGTTGCCAACAAATCTGACCTCCAGAAAACCTACCAGAAGCTTGGGAAGGAGCTGGAAAA；CTCATTATCGACTCTTCGTGTTAGCAAGTTGAGAATTTGAGAAAAATCTGCTGCTATCCTAATGATCTACTTTTGTTTTCAATTTCAGTTTCAAAGGACATTTGAGTCTCTCAAAAAT；CTTATCCTTGCGGACATGATTGATGTCATGTGCCTCTTGCAACATGTGTCAGCTGTAAGTAAAAGATGGCTTAGTTTACCTTGGCATTGTCTTCACTTCTAATTTCATTCTCTGAACC；CAAAAAGGGAGGCTGTGGTTCAAGCTGCCCGTGCCTTGCTGGCTGCGGTGACGAGACTCCTTATCCTTGCGGACATGATTGATGTCATGTGCCTCTTGCAACATGTGTCAGCTGTAAG；TTCAGGTGAAGCTCTGAAAGTATCAGCTGAGAGATTTACAGATGACCCCTGTTTTCTCCCAAAAAGGGAGGCTGTGGTTCAAGCTGCCCGTGCCTTGCTGGCTGCGGTGACGAGACTC；ATAAATCCTGAAATAGGCATAGTTGAAACTTAAAGTATAACTTATATGGGGTTGTATTTTTCAGGTGAAGCTCTGAAAGTATCAGCTGAGAGATTTACAGATGACCCCTGTTTTCTCC；TGAGCTTACGGCTTCACTTGAGGAAGTTCGCAAAGAAAGTGAGTACTCCAATCCTGGTCAGGAGCAAACTGCATATCTTTAGGGTGTTAGTCACCCAAATTAGATTTGTGAGTGTTTT；ACTTGGAATTTATTAGACAAGGGAGAGAAGATTGCCCAGGAAGCTACAGTTTTAAAGGATGAGCTTACGGCTTCACTTGAGGAAGTTCGCAAAGAAAGTGAGTACTCCAATCCTGGTC；GCAGGAAAAAAGGACGTTCGAAAAGAGCCAGTGTCCTTCTAGCTTCTGTGGAGGAAGCAACTTGGAATTTATTAGACAAGGGAGAGAAGATTGCCCAGGAAGCTACAGTTTTAAAGGA；CTTTGTATTTTTCCAATTTTAGGTTACCACACTTGTAAACTGTCCCCAGAACCCTTCCAGCAGGAAAAAAGGACGTTCGAAAAGAGCCAGTGTCCTTCTAGCTTCTGTGGAGGAAGCA；TTTGTTCTGGTCTGTAATATCCCAGGACTGTGTTCTCCTTACAATTTGTCAATTTAGTACTTTGTATTTTTCCAATTTTAGGTTACCACACTTGTAAACTGTCCCCAGAACCCTTCCA；GATCTGCAGGTCCAAACATTCACCGTGGAGAAGCTACTGGAGCCTCTCATAATCCAGGTATTAATACCATGGAAATTATGATATATAGTAACTGCAGAAGAATGAAAAATATGTGGG；GTTTGTGCACAGGCAGCATGTCAGCTGAAACACCAATCACATTGAATATCGATCCTCAGGATCTGCAGGTCCAAACATTCACCGTGGAGAAGCTACTGGAGCCTCTCATAATCCAGGT；GATTTCATAAGTGTTCTTCTTTAGAAAACAGTTTTCTTTATTAATAAGCATCCTTTTGTGTTTGTGCACAGGCAGCATGTCAGCTGAAACACCAATCACATTGAATATCGATCCTCAG；GAAGGAGAATGAAATCAACGCAAAGGAGAGAGAAACAAGGTAAAACAGGGCTAAATTGTAGGGCTTTGACTTTATATGTTGATGTATCATATGCCAATAACAGTAATTTGAAACTTTG；AGCGTGTCTCTTACATTGCAGCTGAATCGCTGAGAAAAGAGACCATGTTTCTACTTTTAGAAGGAGAATGAAATCAACGCAAAGGAGAGAGAAACAAGGTAAAACAGGGCTAAATTGT；
所述探针组4由如下核酸分子组成：
TACCACTCCCTTAAAGACTGAGGAAAATGACAAAGTATTCTCGGCTGCAAAAATCCCCAAAGGAAAACACCTATTTTTCTACTACCCAGCCCAAGAAACCTCAAAAGCATGCCTTGTT；TTATTCCAAAGGCTCAGTTTAAGAAGACAGATTTTGTCAACAGCCGGACTGCCAAAGCCTACCACTCCCTTAAAGACTGAGGAAAATGACAAAGTATTCTCGGCTGCAAAAATCCCCA；CGCTAAAAAACTGCATTTTCTTGTGTGCCAGTTTTGTTACCTTTCACGTTTCTGTTTGCTTATTCCAAAGGCTCAGTTTAAGAAGACAGATTTTGTCAACAGCCGGACTGCCAAAGCC；ATTCTCTGTGGGCACACACGGAACTGCATCATGCCTACAAGAAGGTAAGAACATGAACAAGGAATGTGTCATAGTTAACAGAGCCAGGTAATAATGGCCCACTTGACTTGACCCTGGG；TCCTTTTCTTTTCAGCTATGCCTCCAACAAAGCAAGTAAAGCTGCTTCCGTCCTTCTGTATTCTCTGTGGGCACACACGGAACTGCATCATGCCTACAAGAAGGTAAGAACATGAACA；TACAGAACACCCACAGGCCGCATCCAGAAGCCTCACTCATTCTCCCTGATCTCAGAATGTCCTTTTCTTTTCAGCTATGCCTCCAACAAAGCAAGTAAAGCTGCTTCCGTCCTTCTGT；CATCCAGAAAATTATGGCCATTAGTGCAGGCGATGCGTAAGTCCTTCAGTTCTGCCCGTCAGCTGCCTCCCTTTCCCCTCACCAGCCTGTGTGTAAATAATCCGGTTGTGAATGTGCG；TTGAACAACATAATCCAAAACAGTTACCAGAATGCACGCGACCTTCTAAACACCGGGGGCATCCAGAAAATTATGGCCATTAGTGCAGGCGATGCGTAAGTCCTTCAGTTCTGCCCGT；CTGACACAGTCCCGAGTACTGACCTTCTCATTGAAACTACAGCCTCTGCCTGTTACACATTGAACAACATAATCCAAAACAGTTACCAGAATGCACGCGACCTTCTAAACACCGGGGG；TTGTTTTTTTTTTCATTTTGTAGCCAAAGAAACTCTCCCTGATTTGGTTTCCATCATTCCTGACACAGTCCCGAGTACTGACCTTCTCATTGAAACTACAGCCTCTGCCTGTTACACA；CTTCACCCAAAATATATTGGGATCTTGGGATTAAGAAACAATCTTTTTAATCAAGTGTTTTGTTTTTTTTTTCATTTTGTAGCCAAAGAAACTCTCCCTGATTTGGTTTCCATCATTC；GCTGCTGAGGAATCTGTCCCGGAATCTTTCTCTGCAGAATGAAATTGGTGAGTCGGTATAAGTATCTATGTGTAATATGTACATGCTGAAGATACAATGCAATGAAATGTTGTCTGTA；CAGCACACCCGAAAGATGCTGCATGTTGGTGACCCAAGTGTGAAAAAGACAGCCATCTCGCTGCTGAGGAATCTGTCCCGGAATCTTTCTCTGCAGAATGAAATTGGTGAGTCGGTAT；TCACAAAACAGATGCCGACATCAGTGGCTCAGACAGTTGTCCAGAAGGAAAGTGGCCTGCAGCACACCCGAAAGATGCTGCATGTTGGTGACCCAAGTGTGAAAAAGACAGCCATCTC；TCTACAGAAAACTTAATGTTATCGTGAAATCAAATACAATAGCACTTATAGGATATGTCTCACAAAACAGATGCCGACATCAGTGGCTCAGACAGTTGTCCAGAAGGAAAGTGGCCTG；TACACACAAGAAGCATCCTTAGGAGCTCTGCAGAACCTCACGGCCGGAAGTGGACCAGTGAGTATTGGGCCTGATTTCCTACTTTTTAAAATAATGATATTGTAGACATACCTACATT；TGTGGCATTCCATTGTTATAAGGATGTATCTGTCCTTGATCGCCAAAAGTGTCCGCAACTACACACAAGAAGCATCCTTAGGAGCTCTGCAGAACCTCACGGCCGGAAGTGGACCAGT；GCAATACCAGGACGTGCCGATGCCGGAGGAAAAGAGCAACCCCAAGGGCGTGGAGTGGCTGTGGCATTCCATTGTTATAAGGATGTATCTGTCCTTGATCGCCAAAAGTGTCCGCAAC；GTGAAATTATAGCCATCACCTGACATGCATTAATTCTGGATTCCTTTTGTGTGTGGTCAGCAATACCAGGACGTGCCGATGCCGGAGGAAAAGAGCAACCCCAAGGGCGTGGAGTGGC；GACAACAACAAAAGTATTGGATGTTTTGGCAGTCGAAGCAGGAAAGTAAAAGAGGTATATTGGGAAGTTTTTGAAAGAATGAGAAAGGGAGAGAATGAGAGAGAGTGTGTGTTTGTGT；CAGAGCTCCCAGAGAAATATTCCCAGAATATCTATATTCAAAACCGGAATATCCAGACTGACAACAACAAAAGTATTGGATGTTTTGGCAGTCGAAGCAGGAAAGTAAAAGAGGTATA；TTCTCAGGCCACGGAGAATTGTGTGTGCATTCTTCATAACCTCTCCTACCAGCTGGAGGCAGAGCTCCCAGAGAAATATTCCCAGAATATCTATATTCAAAACCGGAATATCCAGACT；CTGTGATATCACACCTGCAAGGATATCTATATGTATACGATCAATATTCTTGTCCTGTTTTCTCAGGCCACGGAGAATTGTGTGTGCATTCTTCATAACCTCTCCTACCAGCTGGAGG；CCATTGCAGATTACCAGCCAGATGACAAGGTAATTCAAGAGATAAATATCCTGTTTTGTCTTACTAAGATGCTTCAGAATATTCTTAAGATAGCCGCTTGGTTTTAGGTTTATTCACT；AAAAGCGATGAGAAGATGTGACGGACTCATTGACTCACTGGTCCATTATGTCAGAGGAACCATTGCAGATTACCAGCCAGATGACAAGGTAATTCAAGAGATAAATATCCTGTTTTGT；ACTTTTTTGTTTTTTGTTTTTTCTGATAGAAACATGAGTTCTGCTGGCGCTGATGGGAGAAAAGCGATGAGAAGATGTGACGGACTCATTGACTCACTGGTCCATTATGTCAGAGGAA；GGAAGAAGCATCAAGTAAAACTTCAAAACAAAGACCTGTTGGATACACAGCCTAGACTTACTTTTTTGTTTTTTGTTTTTTCTGATAGAAACATGAGTTCTGCTGGCGCTGATGGGAG；CATATTCTACAACGTCACTGGATGCCTAAGGTAATGCTACCTGTACCCTGCCCTGATAGAAGATGCAATAAAAAATTAGGTAGCCCCAAGGAAGTCAGGATATATTCTGCCTTTGGTT；CCCTTTTCTGGGTGGCCTGAAGGAGACTACCCAAAAGCAAATGGTTTGCTCGATTTTGACATATTCTACAACGTCACTGGATGCCTAAGGTAATGCTACCTGTACCCTGCCCTGATAG；AACTCAAGAATCTCATGATAACAGAAGCATTGCTTACGCTGACGGAGAATATCATCATCCCCTTTTCTGGGTGGCCTGAAGGAGACTACCCAAAAGCAAATGGTTTGCTCGATTTTGA；GTTTTCATGGTAACTCTGTGCTTTTCTAGGTTTGCTGTGGAATTTGTCATCTAATGACAAACTCAAGAATCTCATGATAACAGAAGCATTGCTTACGCTGACGGAGAATATCATCATC；CCTGGAGTTGATGGCCTTGACTGAACTTTTCAGCGGTCATTTTGGTCCCACCCTGCACTGTTTTCATGGTAACTCTGTGCTTTTCTAGGTTTGCTGTGGAATTTGTCATCTAATGACA；ACATTTGCTGTGTTCATAAAGGAGCCTGCCCTGAGTACCTATGCTTCCTCTTTCCTTTGTACAGACCATACAGTCAATTTAAGAAGTAGGAATGGCTGGCCGGGCGCGGTGGCTCACG；GGCTCTTATTTCAGGGGAGGTGATGTTTGCCACATAGTTCAGCCAAGTCTGCCACATTTGCTGTGTTCATAAAGGAGCCTGCCCTGAGTACCTATGCTTCCTCTTTCCTTTGTACAGA；TGCTGAAGCAAACCAGAGACTTGGAGACTAAAAAACAAATAACAGGTAGTGCTTACTGAACATTGAAGAACCTAACACATTTGCACCCCAGCCAGATGCCTTACATCATCTCTTTTTC；AGACAATGACAACAAATTGGAGGTGGCTGAACTAAATGGGGTACCTCGGCTGCTCCAGGTGCTGAAGCAAACCAGAGACTTGGAGACTAAAAAACAAATAACAGGTAGTGCTTACTGA；GTTCAGAATGAAGACGTTCAGCGAGCTGTGTGTGGGGCCTTGAGAAACTTAGTATTTGAAGACAATGACAACAAATTGGAGGTGGCTGAACTAAATGGGGTACCTCGGCTGCTCCAGG；TGCTTCTTCCCCAGGTTAACCAGCTTCGTGGCATCCTCAAGCTTCTGCAGCTCCTAAAAGTTCAGAATGAAGACGTTCAGCGAGCTGTGTGTGGGGCCTTGAGAAACTTAGTATTTGA；GTTTGTATTACATTGAATGCCTTGATGCCACATCAAAATTAATATTAGAAATATGCATCTGCTTCTTCCCCAGGTTAACCAGCTTCGTGGCATCCTCAAGCTTCTGCAGCTCCTAAAA；CAGCACGAGTGCTTCCAGAAATCTGAAGCTCGGAAGAGGGTGAGTGTCATCTTCAGTCCATTGCAAAGCGCAACACACTTTCACTTCTATTATGGTGACTTTGCACACTGAAACCAAT；GTATGCTCGAGGCAGACCACATGCTGCCATCCAGGATTTCTGCTGCAGCTACTTTCATACAGCACGAGTGCTTCCAGAAATCTGAAGCTCGGAAGAGGGTGAGTGTCATCTTCAGTCC；AATCTGTGCCTGTTTGTCTAGGAATGCAGACATGGAGATGACTCTGGAGCGAGCAGTGAGTATGCTCGAGGCAGACCACATGCTGCCATCCAGGATTTCTGCTGCAGCTACTTTCATA；GAGTCGTCTCTGGAGGACCAGGTTGGTAGGCAGGAGGAGGGAGGTTTGGAATCTGGCTGAATCTGTGCCTGTTTGTCTAGGAATGCAGACATGGAGATGACTCTGGAGCGAGCAGTGA；GGGAAGTGGGAATCTGCTCACTGAGAGAAGCACTTTCACTGACTCCCAGCTGGGGTAAGTCCCCTCCTGACTCTGCAGTTCAGTCATTGCCAGCACATTCTGTTCCCACAGCCCTGAC；GTCGCCGTGGATTCCAGCGGGAGGAGAGCGCACTTGACTGTCGGCCAGGCGGCCGCAGGGGGAAGTGGGAATCTGCTCACTGAGAGAAGCACTTTCACTGACTCCCAGCTGGGGTAAG；CCTCCTGGCATCAGAGCTCCTTCCACAGCACCCGCACGCTGAGGGAAGCTGGGCCCAGTGTCGCCGTGGATTCCAGCGGGAGGAGAGCGCACTTGACTGTCGGCCAGGCGGCCGCAGG；CGGGCAGGTCAGGCCGCTGGTGCCCCTGCAGCCCGTCACTCAGAACAGGGCTTCCAGGTCCTCCTGGCATCAGAGCTCCTTCCACAGCACCCGCACGCTGAGGGAAGCTGGGCCCAGT；AGCCGCAGCATGGGCAACCTCTTGGAGAAGGAGAACTACCTGACGGCAGGGCTCACTGTCGGGCAGGTCAGGCCGCTGGTGCCCCTGCAGCCCGTCACTCAGAACAGGGCTTCCAGGT；CCGTTTTTGACAGCATCCCTGCCAACCCGGCCCTGCTCACGTACCCCAGGCCAGGGACCAGCCGCAGCATGGGCAACCTCTTGGAGAAGGAGAACTACCTGACGGCAGGGCTCACTGT；CAGGCAGCGCCACTTTGACACATACCACAGACAGTACCAGCATGGCTCTGTTAGCGACACCGTTTTTGACAGCATCCCTGCCAACCCGGCCCTGCTCACGTACCCCAGGCCAGGGACC；GTGCCACCGAGATATGCTCGTTCCGAGATCGTGGGGGTCAGCCGTGCTGGCACCACAAGCAGGCAGCGCCACTTTGACACATACCACAGACAGTACCAGCATGGCTCTGTTAGCGACA；AGAGAAGCCAGGCTGGGCACACCCTGCACCACCAAGAAAGCAGGCGGGCCGCCCTCCTAGTGCCACCGAGATATGCTCGTTCCGAGATCGTGGGGGTCAGCCGTGCTGGCACCACAAG；TTCTCCTGACAGCAGCCCGGAGAGGGCTCACTACACGCACAGCGATTACCAGTACAGCCAGAGAAGCCAGGCTGGGCACACCCTGCACCACCAAGAAAGCAGGCGGGCCGCCCTCCTA；AGCTCCCAGAAGTCCGTGGAAGAAAGGTCCTTGAGGCATCCTCTGAGGAGACTGGAGATTTCTCCTGACAGCAGCCCGGAGAGGGCTCACTACACGCACAGCGATTACCAGTACAGCC；TGCAGGCTGGCACAACTGCCACTTATGAAGGTCGCTGGGGAAGAGGAACAGCACAGTACAGCTCCCAGAAGTCCGTGGAAGAAAGGTCCTTGAGGCATCCTCTGAGGAGACTGGAGAT；TAGTCCTCAGCAAAGTTGAAATTTGATTTATGCCCCCTTTAAACTTTATTTCTCTCATGTGCAGGCTGGCACAACTGCCACTTATGAAGGTCGCTGGGGAAGAGGAACAGCACAGTAC；GAAAATGATTTTGTTGGAGGCCGTTCCCCTGTTCCTAAAACCTATGACATGCTAAAGGTAGGATATCAAAGAATGTAACCCTAGTGATCAGATTACTACCATGAAAATATTTTCAAAC；CAGGAAATCTTCACCGAACCAGCAGTGTTCCTGAGTATGTCTACAACCTACACTTGGTTGAAAATGATTTTGTTGGAGGCCGTTCCCCTGTTCCTAAAACCTATGACATGCTAAAGGT；GTCTGTAAATATTAATTAGCCTACTTGTATTCTGAGTTATTTTAATATTTGCTTGATTGCAGGAAATCTTCACCGAACCAGCAGTGTTCCTGAGTATGTCTACAACCTACACTTGGTT；CGCCCGGAAGGGCCGCAGCTCCGTGGGCAACGGTGAGTGGAGCCCGCCGCTCCCCGGCGCCGCCCCCTGCCCCACACCCGGTCACCTCCTCCTATCCCGCCCTCACCCCGCGTGCTGG；GGCCGCGGCGGCCAGACAGTCAAGAGCCTGCGGATCCAGGAGCAGGTGCAGCAGACCCTCGCCCGGAAGGGCCGCAGCTCCGTGGGCAACGGTGAGTGGAGCCCGCCGCTCCCCGGCG；TGGACAGCTCCAGCCTGGCGCTGCCCTCCGAGGCCAAGCTGAAGCTGGCGGGGAGCAGCGGCCGCGGCGGCCAGACAGTCAAGAGCCTGCGGATCCAGGAGCAGGTGCAGCAGACCCT；CGCCCCAGCTGAGTACGGCTACATCCGGACCGTCCTGGGCCAGCAGATCCTGGGACAACTGGACAGCTCCAGCCTGGCGCTGCCCTCCGAGGCCAAGCTGAAGCTGGCGGGGAGCAGC；CGAGTCCAGAGGCAGGCGAGCAGCTCGGTCGCCCCCACCGGCCCCATGGCAGCCCCCGGCGCCCCAGCTGAGTACGGCTACATCCGGACCGTCCTGGGCCAGCAGATCCTGGGACAAC；CGGACTCGAGCGGGGCGGGGCTCGCGCCAGCGCCCCCAGCTCCGTGGCGGCTTCGCCCGCGAGTCCAGAGGCAGGCGAGCAGCTCGGTCGCCCCCACCGGCCCCATGGCAGCCCCCGG；
所述探针组5由如下核酸分子组成：
CCCCAAAGTGGAGCAGCTCTCCAACATGGTGGTGAAGTCTTGTAAATGTAGCTGAGACCCCACGTGCGACAGAGAGAGGGGAGAGAGAACCACCACTGCCTGACTGCCCGCTCCTCGG；CCTTGCTGCGTGCCCCAGGACCTGGAGCCCCTGACCATCCTGTACTATGTTGGGAGGACCCCCAAAGTGGAGCAGCTCTCCAACATGGTGGTGAAGTCTTGTAAATGTAGCTGAGACC；ATGTCCCTTCCCAGGTGCTGGGACTGTACAACACTCTGAACCCTGAAGCATCTGCCTCGCCTTGCTGCGTGCCCCAGGACCTGGAGCCCCTGACCATCCTGTACTATGTTGGGAGGAC；GAACTGGGCGACTTCCTGGGTTCCAGGCCTGAGACTTGGCCTTCCAACCTCTCACTGACATGTCCCTTCCCAGGTGCTGGGACTGTACAACACTCTGAACCCTGAAGCATCTGCCTCG；CAGGCCCTTGCCCATACCTCCGCAGTGCAGACACAACCCACAGCACGGTATGGAGCAGGCTCATGCCATCTGAGGCACTGGGGCTGACCGACCAGACCACTTGTTAAAAAGAATGAGT；ACAGGATCTGGGCTGGAAGTGGGTCCATGAACCTAAGGGCTACTATGCCAACTTCTGCTCAGGCCCTTGCCCATACCTCCGCAGTGCAGACACAACCCACAGCACGGTATGGAGCAGG；TTTTGTTGTAGCAACTTGGAGGAGAACTGCTGTGTGCGCCCCCTCTACATTGACTTCCGACAGGATCTGGGCTGGAAGTGGGTCCATGAACCTAAGGGCTACTATGCCAACTTCTGCT；TGAGAGCATTCATGAAGTTTCTTTTATTGGTGGTTTTAAGTTGATTTTCTATAAATGTTTTTTGTTGTAGCAACTTGGAGGAGAACTGCTGTGTGCGCCCCCTCTACATTGACTTCCG；CCCGGGCCAGGGGGGTCAGAGGAAGAAGCGGGCTTTGGACACCAATTACTGCTTCCGGTGAGACTGGGCCCACATGGGAACCAACATCTACTGCCTGCCTACTGCCCAATGGCTAGGT；AAGGATCACCACAACCCTCATCTAATCCTCATGATGATTCCCCCACACCGGCTCGACAACCCGGGCCAGGGGGGTCAGAGGAAGAAGCGGGCTTTGGACACCAATTACTGCTTCCGGT；CAGGCGTGGACAATGAGGATGACCATGGCCGTGGAGATCTGGGGCGCCTCAAGAAGCAGAAGGATCACCACAACCCTCATCTAATCCTCATGATGATTCCCCCACACCGGCTCGACAA；GCAGCCTCCAAGGGCTCTGCTCTCTTCAGACAGGAGATTGTCACTTTCCTTCCCTTCTTCAGGCGTGGACAATGAGGATGACCATGGCCGTGGAGATCTGGGGCGCCTCAAGAAGCAG；CCAATGGAGATATCCTGGAAAACATTCACGAGGTGATGGAAATCAAATTCAAAGGTAACAAAATGAATGTGTATGGTAGGATGGGTGAGTGGGGGGGAAGTTAATGGGACAGGATAGT；TGCAGAGTCCAACTTAGGTCTAGAAATCAGCATTCACTGTCCATGTCACACCTTTCAGCCCAATGGAGATATCCTGGAAAACATTCACGAGGTGATGGAAATCAAATTCAAAGGTAAC；GTGGTGGGCACACTTCCCCATCACACAGAGGTGCTTTTCTCACTAATTCTGTCTTATTTTGCAGAGTCCAACTTAGGTCTAGAAATCAGCATTCACTGTCCATGTCACACCTTTCAGC；CACTGACACTGTGCGTGAGTGGCTGTTGAGAAGAGGTAGGTGGACCCTTCAGATAAGCATTTCAGAATGAACCTCAGGTCCCTTAGTCCTCCATGAAATGGAGGGAAGAGGACAGAAT；TATATCGGTGGCAAGAATCTGCCCACACGGGGCACTGCCGAGTGGCTGTCCTTTGATGTCACTGACACTGTGCGTGAGTGGCTGTTGAGAAGAGGTAGGTGGACCCTTCAGATAAGCA；TCACTCCTTTCTCTGCCCTGTAGATCCTTCGGCCAGATGAGCACATTGCCAAACAGCGCTATATCGGTGGCAAGAATCTGCCCACACGGGGCACTGCCGAGTGGCTGTCCTTTGATGT；CCTCACCTGTGCTCTGCATTGTGACATCTTCTGGGGCACTCTGTCCTGGTCTCGGGTACTCACTCCTTTCTCTGCCCTGTAGATCCTTCGGCCAGATGAGCACATTGCCAAACAGCGC；GGGTGCCCAACCCCAGCTCTAAGCGGAATGAGCAGAGGATCGAGCTCTTCCAGGTAACTCCTCTCTCAGAGCAGAAACCACACCGACGGGAAAGCTGGTTCCTTTGCCATATCAGGGC；TGTGTCCTCAGTGGAGAAAAATAGAACCAACCTATTCCGAGCAGAATTCCGGGTCTTGCGGGTGCCCAACCCCAGCTCTAAGCGGAATGAGCAGAGGATCGAGCTCTTCCAGGTAACT；CTCCTAGACGAACTGGCTGTCTGCCCTAAAGGAATTACCTCCAAGGTTTTCCGCTTCAATGTGTCCTCAGTGGAGAAAAATAGAACCAACCTATTCCGAGCAGAATTCCGGGTCTTGC；GTTGGCAGCACACTGTTCCTGCATGTCTCGCTCATGCTGTGCCCTCTGCTCTGCTTTATCTCCTAGACGAACTGGCTGTCTGCCCTAAAGGAATTACCTCCAAGGTTTTCCGCTTCAA；ATAAATTCGACATGATCCAGGGGCTGGCGGAGCACAGTAAGTCCAAATTCTCGCTGGGGTGTCTGCTCTGGAGGGTCTGAACTGGAGCTGGGAGCTCTGCAGAGGGGGGCCTAGTGCT；GAGGGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATAAATTCGACATGATCCAGGGGCTGGCGGAGCACAGTAAGTCCAAATTCTCGCTGGGG；TATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGAGGAGATGCATGGGGAGAGGGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCC；TCTTGAGCAAGCTCAGGCTCACCAGCCCCCCTGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGAGGAGATGCATGGGGA；CACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGGCTCACCAGCCCCCCTGAGCCAACGGTGATGACCCACGTCCCC；GCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTTGCACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGA；GCCTTGCCGTCCCCCTGGCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTTG；GAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGTCCCCCTGGCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAAGG；
所述探针组6由如下核酸分子组成：
ACGGCCTCAGGCCCCCGTACCCCACTGCAGACCACATGCTGGCCTAGGCGGCCTGGCCCCAGTACGGCCCCCTCTTTGCAGGCTTTTCCTCCTCTCTAGAACCTCCTTCTGTTGGAGG；TGACCCGCTGGAGATGCACATGGACATGGATGGAGACTACCCCATCGACACCTACAGCGACGGCCTCAGGCCCCCGTACCCCACTGCAGACCACATGCTGGCCTAGGCGGCCTGGCCC；TTTTTGTCCCCAGACATGGATGCCACCTACCGCCCCATGTACTCCAGCGATGTGCCCCTTGACCCGCTGGAGATGCACATGGACATGGATGGAGACTACCCCATCGACACCTACAGCG；GAAGGCTGTGCAGACTGCTCCCTGCAGGGTAGCTTGCAGACCCTAGGACCGAGCCCCACTTTTTGTCCCCAGACATGGATGCCACCTACCGCCCCATGTACTCCAGCGATGTGCCCCT；CTTTTTCAGGCCCAGAGCATGATTCCCATCAATGAGCCCTATGGAGATGGTAAGTGTGTGCCGGGCTCTTCAGGACCCTGGAGATCCTGGGCGGCTGTGTGGGTGTGTGTGAGGGGAC；CCAGCTGAGATCCAGCTCGGAGCCTGCATTTTCAAACCTCCCCTCCATGTTTCTCTCTCCTTTTTCAGGCCCAGAGCATGATTCCCATCAATGAGCCCTATGGAGATGGTAAGTGTGT；GGAAGCGCGTGTCCGTGGAGCTCACCAACTCCCTCTTCAAGCATGACCCGGCTGCCTGGGAGGCTGTGAGTATCCTAGGTTGGACCACAGTAGTTGGTTGTGCAAGTTGGGCACTGC；AGCCACCTACGCTGCTGCCGTCCTGTTCCGCATCTCCGAGGACAAGAACCCAGACTACCGGAAGCGCGTGTCCGTGGAGCTCACCAACTCCCTCTTCAAGCATGACCCGGCTGCCTGG；CCCCAGCCACGATGGAGGCTGGCCGACGTTTAACCTGGCTTTTCCTTTCCTCTCTGCTCAGCCACCTACGCTGCTGCCGTCCTGTTCCGCATCTCCGAGGACAAGAACCCAGACTACC；TCGGCCCCACTCATGGAGTTGCTGCACTCCCGCAACGAGGGCACTGGTGAGCTGGGGGAGGGCAGGAGGCTGGGTCCCACTCCCCCAGCCACGATGGAGGCTGGCCGACGTTTAACCT；TGCTGTGTGAGCTGGCCCAGGACAAGGAGGCGGCCGACGCCATTGATGCAGAGGGGGCCTCGGCCCCACTCATGGAGTTGCTGCACTCCCGCAACGAGGGCACTGGTGAGCTGGGGGA；CCCCTCTCCCCAGCTCCTGTACTCGTCGGTGGAGAACATCCAGCGCGTGGCTGCCGGGGTGCTGTGTGAGCTGGCCCAGGACAAGGAGGCGGCCGACGCCATTGATGCAGAGGGGGCC；TGTGGGGTGTGTTGTCCGGCCTGCCTCACCCCTTTCCACCTCTCCCCTGCTTCCCACGTCCCCTCTCCCCAGCTCCTGTACTCGTCGGTGGAGAACATCCAGCGCGTGGCTGCCGGGG；CCGGCTCAACACCATTCCCCTGTTTGTGCAGGTGAGTCTGGGGCAGGTGGGCAGGAGAGGTCCCCCCACCACTGCTTAAAGGGCAAGGTTAGGAGTCCCAGATTTGGGAGGCCTGGAC；GGCTGCACCGGAGCACTGCACATCCTCGCCCGGGACCCCATGAACCGCATGGAGATCTTCCGGCTCAACACCATTCCCCTGTTTGTGCAGGTGAGTCTGGGGCAGGTGGGCAGGAGAG；TCCCATGCCCCCTGCCTCCTCTCACACAGGATGGTGTGAGGATGGAGGAGATTGTGGAGGGCTGCACCGGAGCACTGCACATCCTCGCCCGGGACCCCATGAACCGCATGGAGATCTT；ACCTGTGAAGTTCATTCGGCTGTCATGGGGAGGAGTTGTGGCCATGTCCAAGGCACCTGTCCCATGCCCCCTGCCTCCTCTCACACAGGATGGTGTGAGGATGGAGGAGATTGTGGAG；CCAGGATGCCCAGCGCCACGTAGCTGCAGGCACACAGCAGCCCTACACGGTATGTGAGCTGGTGGTGCCTCTGACAGCCTTCCTGGGGGGTCAGGGTGTCCTCTGTGGGTGTGTGTGT；GCCCCGCTGCAGGAGGCAGCGGTCATCCCCCGCCTCGTCCAACTGCTGGTGAAGGCCCACCAGGATGCCCAGCGCCACGTAGCTGCAGGCACACAGCAGCCCTACACGGTATGTGAGC；TTTTTTGCCAGGCAACCATCGGCTTGATCAGGAATCTGGCCCTGTGCCCAGCCAACCATGCCCCGCTGCAGGAGGCAGCGGTCATCCCCCGCCTCGTCCAACTGCTGGTGAAGGCCCA；TGAAGCTGGGAAGCTGGGATCCTTCAGATGTCCAAGAAGTGCCCCTGATCACTGCCCCTTTTTTTGCCAGGCAACCATCGGCTTGATCAGGAATCTGGCCCTGTGCCCAGCCAACCAT；CCAGCCATCGTGAAGCTGCTCAACCAGCCCAACCAGTGGCCACTGGTCAAGGTACTGCTGTTAGGCGAGGGGAAGGAGCTCCCTGCAGCAGGCTTAGGTGCTGTATTGGTATAGGCAA；CTAGCCGCCACCCTGAGGCCGAGATGGCCCAGAACTCTGTGCGTCTCAACTATGGCATCCCAGCCATCGTGAAGCTGCTCAACCAGCCCAACCAGTGGCCACTGGTCAAGGTACTGCT；GCGTGCTGGTGACAAGGACGACATCACGGAGCCTGCCGTCTGCGCTCTGCGCCACCTCACTAGCCGCCACCCTGAGGCCGAGATGGCCCAGAACTCTGTGCGTCTCAACTATGGCATC；AAGAACAAGACGCTGGTGACACAGAACAGCGGTGTGGAGGCTCTCATCCATGCCATCCTGCGTGCTGGTGACAAGGACGACATCACGGAGCCTGCCGTCTGCGCTCTGCGCCACCTCA；ACGTCAACGTCCTCACCTGTGCCACGGGCACACTCTCCAACCTGACATGCAACAACAGCAAGAACAAGACGCTGGTGACACAGAACAGCGGTGTGGAGGCTCTCATCCATGCCATCCT；CCTCCAGGAGGGCCTGGAGAGTGTGCTGAAGATTCTGGTGAATCAGCTGAGTGTGGATGACGTCAACGTCCTCACCTGTGCCACGGGCACACTCTCCAACCTGACATGCAACAACAGC；CATATTCGAGAAGGCTCCCTGGAGTTGGCTGCTCCCTGACTCCCCCGTCCCTTCCTTGCCCTCCAGGAGGGCCTGGAGAGTGTGCTGAAGATTCTGGTGAATCAGCTGAGTGTGGATG；GCAGAACTGCCTGTGGACCCTGCGCAACCTCTCAGATGTGGCCACCAAGCAGGTGAGGGAGGTATCTGGGCCTGGGGTTGACCTCTTCAGCTGCCCCATCCAGCCTCCTGTCTGGGCA；GCCCCAGGTGGGATGCAGGCCCTGGGCAAGCACCTGACCAGCAACAGCCCCCGCCTGGTGCAGAACTGCCTGTGGACCCTGCGCAACCTCTCAGATGTGGCCACCAAGCAGGTGAGGG；TGCCCAGCTGCCAGGCTCAGTCAGCCATGCTCCCCGTGGCTGATGGCACCCCTATCCCTGCCCCAGGTGGGATGCAGGCCCTGGGCAAGCACCTGACCAGCAACAGCCCCCGCCTGGT；GCTATCCGTGTGTCCCAGCAATAAGCCTGCCATTGTGGAGGCTGGTGAGTATGATGGCCTTGAGGGCGGCTGGGGTGGGAGCTCTGCCCAGCTGCCAGGCTCAGTCAGCCATGCTCCC；ATCATGCGTAACTACAGTTATGAAAAGCTGCTCTGGACCACCAGTCGTGTGCTCAAGGTGCTATCCGTGTGTCCCAGCAATAAGCCTGCCATTGTGGAGGCTGGTGAGTATGATGGCC；TCCCTCTTTACCCATAGCTGATCATCCTGGCCAATGGTGGGCCCCAGGCCCTCGTGCAGATCATGCGTAACTACAGTTATGAAAAGCTGCTCTGGACCACCAGTCGTGTGCTCAAGGT；CTGTCTCCTGTCCCGCGCTTCCTTGTTCCTGTCATATTCCCCGTCCATCTCACACTCATTCCCTCTTTACCCATAGCTGATCATCCTGGCCAATGGTGGGCCCCAGGCCCTCGTGCAG；GACTGCCTGCAGCTCCTGGCCTACGGCAACCAGGAGAGCAAGGTGGGCCCTCCCCAACTCTCCCGAGGCCTGAAGCCCACCCTTGCGCCATCTTCTATCCTGCACAGCCTTGGGCCGC；TGCAAAAGATGGTGCCCCTGCTCAACAAGAACAACCCCAAGTTCCTGGCCATCACCACCGACTGCCTGCAGCTCCTGGCCTACGGCAACCAGGAGAGCAAGGTGGGCCCTCCCCAACT；GCACAACCTGCTCCTGTACCAGGAGGGCGCCAAGATGGCCGTGCGCCTGGCCGACGGGCTGCAAAAGATGGTGCCCCTGCTCAACAAGAACAACCCCAAGTTCCTGGCCATCACCACC；CCTGCCCACCCCCCCAGCTCCCCTGTGGAGTCGGTCCTGTTCTATGCCATCACCACGCTGCACAACCTGCTCCTGTACCAGGAGGGCGCCAAGATGGCCGTGCGCCTGGCCGACGGGC；TGGGAACCCATGCCAGGCTCACATGTATGCCAGGCCTCTGGGACCTCAGCGTACTAACCCCTGCCCACCCCCCCAGCTCCCCTGTGGAGTCGGTCCTGTTCTATGCCATCACCACGCT；TGGCATCCCTGCTCTGGTCCGCATGCTCAGGTACCCAACCCTGCTCACTGCATGAGCCCAGGACCCCCTCTCACTTGGGCCTCTCCCCTCCCTTCCCTGAGCTTCCATAAATATCCAG；AGCATCCTGCACAACCTCTCCCACCACCGGGAGGGGCTGCTCGCCATCTTCAAGTCGGGTGGCATCCCTGCTCTGGTCCGCATGCTCAGGTACCCAACCCTGCTCACTGCATGAGCCC；CCGCTGTCGTGCGTACCATGCAGAATACCAGCGACCTGGACACAGCCCGCTGCACCACCAGCATCCTGCACAACCTCTCCCACCACCGGGAGGGGCTGCTCGCCATCTTCAAGTCGGG；CCAGCTGTCGAAGAAGGAGGCGTCGCGGCGGGCCCTGATGGGCTCGCCCCAGCTGGTGGCCGCTGTCGTGCGTACCATGCAGAATACCAGCGACCTGGACACAGCCCGCTGCACCACC；GTCCCCGCCCCTGCCTTTGCCCTCCAGGTGGTGGTGACCAAGGCGGCCATGATTGTGAACCAGCTGTCGAAGAAGGAGGCGTCGCGGCGGGCCCTGATGGGCTCGCCCCAGCTGGTGG；CTGACTGGGGCCCTCCTCAGCTCTGTGGAAGGGTATCCCGGCCTCTCCTTAGTGCTCACGTCCCCGCCCCTGCCTTTGCCCTCCAGGTGGTGGTGACCAAGGCGGCCATGATTGTGAA；CCCTGCCCGAGCTCACCAAACTGCTCAACGACGAGGACCCGGTCTGTGAGGGTCCCTGCTAGGGTGGGGGCTGGGCAGGGAGGGGAGAGAGCAGATGTCCTCAGGGGAGGGACATTGT；CAAGTCGGCCATTGTGCATCTCATCAACTACCAGGACGATGCCGAGCTGGCCACTCGCGCCCTGCCCGAGCTCACCAAACTGCTCAACGACGAGGACCCGGTCTGTGAGGGTCCCTGC；ACCCAGGTGGAGGGGCAGGCCACCAACCTGCAGCGACTGGCCGAGCCGTCCCAGCTGCTCAAGTCGGCCATTGTGCATCTCATCAACTACCAGGACGATGCCGAGCTGGCCACTCGCG；GGGTGCGGGAGGCCATGTGCCCTGGTGTGTCAGGCGAGGACAGCTCGCTTCTGCTGGCCACCCAGGTGGAGGGGCAGGCCACCAACCTGCAGCGACTGGCCGAGCCGTCCCAGCTGCT；GTCCCCATGGCCCCCAGGTGATCTGGAGTACCAGATGTCCACAACAGCCAGGGCCAAACGGGTGCGGGAGGCCATGTGCCCTGGTGTGTCAGGCGAGGACAGCTCGCTTCTGCTGGCC；GTCTGTGGCCTGCCCTGCTCCCCAGTGTCTGCCCAGCCCACTGCCTGCACTCAGTCCCTGTCCCCATGGCCCCCAGGTGATCTGGAGTACCAGATGTCCACAACAGCCAGGGCCAAAC；ACGCTCAAGAAAACCACCACTTACACCCAGGGGGTGCCCCCCAGCCAAGGTCAGGACCCCTGGGGACTATTGCATGGGGCAGAAAACCTGCCTGGGTCCTGGAGAGAGGTCAGAGTGA；TGCCCTCCGTCAGCAGCAAGGGCATCATGGAGGAGGATGAGGCCTGCGGGCGCCAGTACACGCTCAAGAAAACCACCACTTACACCCAGGGGGTGCCCCCCAGCCAAGGTCAGGACCC；TGAGTGGCAGCAGACATACACCTACGACTCGGGTATCCACTCGGGCGCCAACACCTGCGTGCCCTCCGTCAGCAGCAAGGGCATCATGGAGGAGGATGAGGCCTGCGGGCGCCAGTAC；GTGCCCCCAGTAGCCACGATGGAGGTGATGAACCTGATGGAGCAGCCTATCAAGGTGACTGAGTGGCAGCAGACATACACCTACGACTCGGGTATCCACTCGGGCGCCAACACCTGCG；TGACGGGCTGAAGCTGGGGGCTGGGCCAGGTGACTTCCTGCTTCCTGACTTCCTCCTTTGTGCCCCCAGTAGCCACGATGGAGGTGATGAACCTGATGGAGCAGCCTATCAAGGTGAC；
所述探针组7由如下核酸分子组成：
AAGCATGCATGAAGAGATGAGTGTGTTCTAATAAGTCTCTGAAAGCCAGTGGCTTTATGACTTTTAAAAAAAATTACAAACCAAGAATTTTTTAAAGCAGAAGATGCTATTTGTGGGG；AGAAGAAGATGGGCTTGAATTTTTGGATAATTTGGAGCCCAAATTTAGGACACTAGCAGAAGCATGCATGAAGAGATGAGTGTGTTCTAATAAGTCTCTGAAAGCCAGTGGCTTTATG；TATAACTATGAAGGAAGAGGATCGGTGGCTGGGTCTGTAGGTTGTTGCAGTGAACGACAAGAAGAAGATGGGCTTGAATTTTTGGATAATTTGGAGCCCAAATTTAGGACACTAGCAG；AAGTGTATCTGTGTAATCAAGATGAAAATCACAAGCATGCCCAAGACTATGTCCTGACATATAACTATGAAGGAAGAGGATCGGTGGCTGGGTCTGTAGGTTGTTGCAGTGAACGACA；GTAAATTTTGGTGTTTAAAATAATAATAATAAAAACGTTGTGTTTTTCCCCTTGGCAGAAAGTGTATCTGTGTAATCAAGATGAAAATCACAAGCATGCCCAAGACTATGTCCTGACA；CACACTCTGATTAAAAATTAAACAATGAAAGGTAAATCAAAGCAATTACTTTTATGTTAGTAAATTTTGGTGTTTAAAATAATAATAATAAAAACGTTGTGTTTTTCCCCTTGGCAGA；TGTATAGGAATCCATTAGAGGACACACTCTGATTAAAAATTAAACAATGAAAGGTAAATCAAAGCAATTACTTTTATGTTAGTAAATTTTGGTGTTTAAAATAATAATAATAAAAACG；CATGCTATACTGAATTTATAGTGTGATGTATGAAACAGACCAATCATGTGCATTTTTTATGTATAGGAATCCATTAGAGGACACACTCTGATTAAAAATTAAACAATGAAAGGTAAAT；ACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAAGTGAGTTTTCCTAAGTGGCCTACAAATCTATTTTAATTTTCTTTAAACTTTATAAATAACTAACTGGATTCTGACTA；TCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAAGTGAGTTTTCCTAAGTGG；ATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGGGCTGGCCACCATCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTT；CTGCTCAGGGAGTTTGTGGCACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAGACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGGGCTGGCCACCA；CAAATTGTTTTCATTTCAGTATTCTGCGAATGGCTTCACAACCCAAACTGTGGGCGCTTCTGCTCAGGGAGTTTGTGGCACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAGACC；ATCCGCTTGATGTTGTTCTTTTTCATAATTTTGTGTTCCTCTCTGTATTATCCCTAATGCAAATTGTTTTCATTTCAGTATTCTGCGAATGGCTTCACAACCCAAACTGTGGGCGCTT；TGGTAAGTAGTCTGGCTTTTTAAATAAATACAAAGGATGAATTCGCTTATAATGCGTATTCCTTCTAAAATGATCTTTTCTCAGAAAAGTTCTTTTGGTATCAGGCAATTTACCATAG；TGATTTAGCCCAGCAGAACCTAATTGTATCAAACACAGAAGCTCCTGGAGATGACAAAGTGGTAAGTAGTCTGGCTTTTTAAATAAATACAAAGGATGAATTCGCTTATAATGCGTAT；CTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCTAAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTATCAAACACAGAAGCTCCTGGAGATGACAAAG；TATAACTTCATATTATTTTATGATAAACTCAAGTATATTTCTTTCTTCCTCCAGGCATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCTAAACAACCAAAAGTAATTCCTGA；TCCTTGCAATATTGTTGGGCATAGCATTGCTCTTTTGTAAGTCTTAAGTCCTTTCTTGAATTCAAATAATACCCTTTAAAGTAACTTTCAAGACACTTTTTGTTTTTTGAGACAGAG；CACACATCGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCATCCTTGCAATATTGTTGGGCATAGCATTGCTCTTTTGTAAGTCTTAAGTCCTTTCTTGA；ATGTCTAGTGTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACATCGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCA；AGAATGATCCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAGATAGACTTGGCATGTCTAGTGTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTG；GTATAATGTTTGGTTTTATTTATTTATATTTTCAGATACAGCAGCACGTCTTTCCTATCAGAATGATCCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAGATAGACTTGGC；TAGGAAAATATAACTATCTGATAATGAGTTATTTATGTTCAGAAGAAATCAGTGACATTGTATAATGTTTGGTTTTATTTATTTATATTTTCAGATACAGCAGCACGTCTTTCCTATC；TGGAGAGTTCTACTTCAGAAGTACAGAGAATGTGGAGACTGAAAGCAATTAATGGTATATATTTTTGAAAATTGCTTTGTCCTTTTCAACATCAGGATGTCTGCGATACTTTTTTTTT；GGAGATTGTTGCGGTTGATCCTGATGAGCCTATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTACAGAGAATGTGGAGACTGAAAGCAATTAATGGTATA；AACAGCCCATTCATACCTAAAAAGACAGTGATCATCTGCAAACCCACCATGTCATCTGCGGAGATTGTTGCGGTTGATCCTGATGAGCCTATCCATGGCCCACCCTTTGACTTTAGTC；TTCTAGGAGGGAGAACATGTACGGGGACACTGGGCATTATACTTCAAGACGTGAATGATAACAGCCCATTCATACCTAAAAAGACAGTGATCATCTGCAAACCCACCATGTCATCTGC；CAGTGCATACTTTTGTGGTGAAAACTCAAAACATAGAAAAACTATTTTTATTTTCATTTTTCTAGGAGGGAGAACATGTACGGGGACACTGGGCATTATACTTCAAGACGTGAATGAT；AAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAGGTAAGAATTTGTCTTTAAGCCAGCTACATACTTCCTTGGCTACATACATCTTCAGTGTTTAAGCCAACAGTATACA；TGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGCAGAGACCATCAAAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAGGTAAGAATTTGTCTTTA；TTCATCATTACCAACAGGTATAAGAAATTAACTGATCCAACAGGGTGGGTCACCATTGATGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGCAGAGACCATCA；ATATAGCTTATTTTGTTACGTTATTATAATTTAGCATATGATAAATTTTATTATTTTAATTCATCATTACCAACAGGTATAAGAAATTAACTGATCCAACAGGGTGGGTCACCATTGA；AAGCATATGACCCAGAAACAAGAAGTAGCAGTGGCATAAGGTACTTACCATTCTATTTTAGTTTTAAAATATATAGCTTATTTTGTTACGTTATTATAATTTAGCATATGATAAATTT；AATACAGACTGTTCGCATGAAAGAAAATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAAACAAGAAGTAGCAGTGGCATAAGGTACTTACCATTCTATTTT；ACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGAGGGCCCTGAGTGTAACCCTCCAATACAGACTGTTCGCATGAAAGAAAATGCAGAAGTGGGAACAACAAGCAATGGATATA；TTGGTGTAGTTAATGAAGCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCCATGAGCACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGAGGGCCCTGAGTGTAACCCTCC；AATACATTTGCTTTCGTAGCCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAATGAAGCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCCATGAGC；TTAACATTATATATACTCGTTAGCATTGCCAAATATTAAATGAGTTCATCTGATTTTTCAATACATTTGCTTTCGTAGCCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAA；CAAAACCAATGAAGGAGTTCTTTGTGTAGTTAAGGTAAGAATAAATTAGAACATTATTTGTAGTTTATAATATCATAGAATAGCATGCTAGAATTTAATGGAAAGAAAGGAATTCTGA；GCTAATTATACCATTTTAAAGGGCAATGAAAATGGCAATTTTAAAATTGTAACAGATGCCAAAACCAATGAAGGAGTTCTTTGTGTAGTTAAGGTAAGAATAAATTAGAACATTATTT；TGGAAATCTTACGAGTTACTGTTGAGGATAAGGACTTAGTGAATACTGCTAACTGGAGAGCTAATTATACCATTTTAAAGGGCAATGAAAATGGCAATTTTAAAATTGTAACAGATGC；TTTTTGTTTGCTTTTATTATTTTAGTATGTGACATCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAGGATAAGGACTTAGTGAATACTGCTAACTGGAGA；TAGAAGAGTAGGATTTACTTCACATCGTGTTCAATTTTTGTGAGAGTTACTAACGAAATTTTTTGTTTGCTTTTATTATTTTAGTATGTGACATCAGTGGAAGAAAATACAGTTGATG；ATGTAAATGACCACTTGCCAACATTTACTCGTACTTCTGTAAGTGTATGATATTAATTAAAGAAAAATGTATAGACCAGTTTTAATTGTTTAATATGCACATCTCTGGCCTGGCGCAG；CATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATGATGTAAATGACCACTTGCCAACATTTACTCGTACTTCTGTAAGTGTATGATATTAATTA；AAATTCTTTTTTTGTTTTCAGTTAATTGACAAGTACCAGTTGAAAATAAAAGTACAAGACATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATG；AAATTATGGAGTGTAAAGTAAGATTTCAATTATAATGTTGGTGCTTTCCCCCAATAATTAAATTCTTTTTTTGTTTTCAGTTAATTGACAAGTACCAGTTGAAAATAAAAGTACAAGA；ATGCATCCAACTACAGGCGTGATCACCACAACATCATCTCAGCTAGACAGAGAGGTAACATAAACAATAAAACCTGATTATAACGTGGCTATTCAATAGTACCTGTATAACTCCTGTA；ACACACGCCTGAAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCTATGCATCCAACTACAGGCGTGATCACCACAACATCATCTCAGCTAGACAGAGAGGTAAC；TCTAGGCACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGCACACACGCCTGAAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCT；TGAAATAAAGGGAACATAGAACATGTGAATGTTTTGGAGATTAAAAAGGACTTTTCTTCTCTAGGCACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGC；AGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGTGAGTACCTCCTTAAACAATATATGGCAAATTAACTGTGTTTCAATTCATACATTTAGTTTCACTATGTCCGT；CTTCCACTGCCCCTAATAATCAAAATAGAGGATGAAAATGATAACTACCCAATTTTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGTGAGTACCTCCTTA；TTTTACTCTCTTCACAGATAATTGCCTTTGCAACAACTCCAGATGGGTATACTCCAGAACTTCCACTGCCCCTAATAATCAAAATAGAGGATGAAAATGATAACTACCCAATTTTTAC；AGCCAAAATGAATTTGAAGCATACCTCATTTTAAAAGATTATTTTCACTTTTCTCCTTATTTTACTCTCTTCACAGATAATTGCCTTTGCAACAACTCCAGATGGGTATACTCCAGAA；CTTGTATTGTACTCGTCCTGTAGATCGTGAGCAGTATGAATCTTTTGAGGTAAAGTCTAAAATGTGTGTACTGTATTAGCAATGATGATGCTTGGCCATTTTGTCTCTCATTTGCAAT；GGTCCTGGAGTTGACCAAGAACCTCGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGTCCTGTAGATCGTGAGCAGTATGAATCTTTTGAGGTAAAGTCTA；CTACTTTCTAGGTTCAATCTGACACGGCCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCTCGGAATTTATTTTATGTGGAGAGAGACACTGGAAA；TCATAAATATATAGATGAAAGCTCTGCTGAAATAAAGATTTGTCTCATGTATATAATATCTACTTTCTAGGTTCAATCTGACACGGCCCAAAACTATACCATATACTATTCCATAAGA；CTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTACCGTTTTCTTTCTTTCTGCTGTGGGAGTCTATAGTTTCCATCTCTTACCATTATGACACTGAGTATGAAGTT；CTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATTCCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTACCGTTTTCTTTCTT；GTCATTGACTTTATTATTTTTTCCTGTCTTATGAATTGAGGTCCTAAAGAAAAGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATTCCTTGTTCGATG；CAGCTAATCCTCCTGAGAGGAGAAAGATGTGTCATTGTTTAATGTTTGAGAATAAAGTAGTCATTGACTTTATTATTTTTTCCTGTCTTATGAATTGAGGTCCTAAAGAAAAGACATA；AAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAACAAAGGTATACAAGGCTACATAAATGAAGAAATGATATCTTTTCTTCAGACGTAATCAACATTACCAGGGAAGATATGAAAT；TCTATTGTCCTCGGAGAAGAGAAGTTTTACCATATTACTTTCCAACACTGAGAACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAACAAAGGTATACAAGGCTACATAA；TCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTCTATACAACAAATACTATTCTATTGTCCTCGGAGAAGAGAAGTTTTACCATATTACTTTCCAACACTGAGAACCAAG；TGTGCATATTTTCTACAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAATCTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTCTATACAACAAATACTAT；CCCACGTGCATACATTACTGTTAAAACTATATCCTATGTTTTACTTTAAAAATGATTGCTGTGCATATTTTCTACAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAATCTAATTCAT；AAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAAACTTGTTGGTAGAGGTAAGGAAGCCCTAAAATTTGTAATAAATCCTGTTTTGCTGTGGTACATATACGCCATGG；AATATTTATTTGATTTTTTTTCATTTTTTAGATCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAAACTTGTTGGTAGAGGT；CATTATAAATTTATAATTTATATAAATAATATACACATTAAAGTTTTCTTTTTATGCATAATATTTATTTGATTTTTTTTCATTTTTTAGATCTTAATATTTGCCAGTGATGCCTGCA；ACGGAGCCCTCTGCCGGCTGCTCCTGCTGACCCTCGCGGTGAGTGTAGCCGCGGCCACCGCTCCGGGGAAGGGGGCGATCGCCTAGGGTGCAGAGGAAAACTAGGGGAACGGGGATAG；GGCCCGCGACCTGCCCCGAGCCCTCTCCATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTGACCCTCGCGGTGAGTGTAGCCGCGGCCACC；GACTGCGCTCCGGCCGCGGCCCTCGCCCCGCGGAGCCCTCCTACCCCGGCCCGACGCTCGGCCCGCGACCTGCCCCGAGCCCTCTCCATGGAGGCAGCCCGCCCCTCCGGCTCCTGGA；
所述探针组8由如下核酸分子组成：
GGCGGCGGGAGGCGGAGGCGAGGGTGCGATGGCGCGGAGCCCGGGACGCGCGTACGCCCTGCTGCTTCTCCTGGTAAGTGCCGCAAGCGGGACAGGGGAGCCACCGCCGGGGAGGGCG；TGCTGCTTCTCCTGGTAAGTGCCGCAAGCGGGACAGGGGAGCCACCGCCGGGGAGGGCGTCGGTAGGCGAGGTCTAGACCTCGCGACCAGACTTGCCCGCCGCCCTTGTGCGCGTTAC；TTCATGAACAATGTTTTCACACTGAATTGAGCAGTAAATTGGCTAAATATCAAATAATTTTATTTTACAGATCTGCTTTAACGTTGGAAGTGGACTTCACTTACAGGTGAGGAAACAA；TTATTTTACAGATCTGCTTTAACGTTGGAAGTGGACTTCACTTACAGGTGAGGAAACAAAGGGATTATTTCTGCCTTCTGACTCAGGAGGGTTAATTCCATGGCAAACAGGTTGACTG；TTTATTATGTTATAGGACAGCATACTAATGTTCTATATTTATGACACATAATAAATTTTGGCAATATTCTATTGTTATAGGTCTTAAGCACAAGAAATGAAAATAAGCTGCTTCCTAA；GGCAATATTCTATTGTTATAGGTCTTAAGCACAAGAAATGAAAATAAGCTGCTTCCTAAACATCCTCATTTAGTGCGGCAAAAGCGCGCCTGGATCACCGCCCCCGTGGCTCTTCGGG；ACATCCTCATTTAGTGCGGCAAAAGCGCGCCTGGATCACCGCCCCCGTGGCTCTTCGGGAGGGAGAGGATCTGTCCAAGAAGAATCCAATTGCCAAGGTACCTCCTAAAGAGGAACAT；AGGGAGAGGATCTGTCCAAGAAGAATCCAATTGCCAAGGTACCTCCTAAAGAGGAACATGAAATACATGCATATGACTAAAATGTGGTGTGAGAGGACTTTTATGTCTACTTTAAGAT；GCTAAGATCAAATCTAGTAAATTACAGAGAGTTCAACCTGAAACATTCCTGTTATTTTTATGTTAGATACATTCTGATCTTGCAGAAGAAAGAGGACTCAAAATTACTTACAAATACA；ATGTTAGATACATTCTGATCTTGCAGAAGAAAGAGGACTCAAAATTACTTACAAATACACTGGAAAAGGGATTACAGAGCCACCTTTTGGTATATTTGTCTTTAACAAAGATACTGGA；CTGGAAAAGGGATTACAGAGCCACCTTTTGGTATATTTGTCTTTAACAAAGATACTGGAGAACTGAATGTTACCAGCATTCTTGATCGAGAAGAAACACCATTTTTTCTGGTAAGAAG；GAACTGAATGTTACCAGCATTCTTGATCGAGAAGAAACACCATTTTTTCTGGTAAGAAGAATAATTTTAGATTTATTAGTTTGTAGTTTTTCTGTCATAATAAGTGTCATTTGTTTTA；TTTGTTTTATTTTTTCATAGTATGGTAATTTAGTTTTCTTAGCTTAAATCTAATCTTATTTATGTCATGATTTCAGCTAACAGGTTACGCTTTGGATGCAAGAGGAAACAATGTAGAG；TTATGTCATGATTTCAGCTAACAGGTTACGCTTTGGATGCAAGAGGAAACAATGTAGAGAAACCCTTAGAGCTACGCATTAAGGTTCTTGATATCAATGACAACGAACCAGTGTTCAC；AAACCCTTAGAGCTACGCATTAAGGTTCTTGATATCAATGACAACGAACCAGTGTTCACACAGGATGTCTTTGTTGGGTCTGTTGAAGAGTTGAGTGCAGCACGTAAGAGTCTTTTTT；ACAGGATGTCTTTGTTGGGTCTGTTGAAGAGTTGAGTGCAGCACGTAAGAGTCTTTTTTTTTTTTTTTAATAAATAAATACCTAAGATTACTTTATCCCCACTGTAAATAAACACTAA；AAAATAACAGGTAAATATGCTTAAAGTTGAATTTCATCTTAGACATCTTTATTTCTAATGCCAGATACTCTTGTGATGAAAATCAATGCAACAGATGCAGATGAGCCCAATACCCTGA；GCCAGATACTCTTGTGATGAAAATCAATGCAACAGATGCAGATGAGCCCAATACCCTGAATTCGAAAATTTCCTATAGAATCGTATCTCTGGAGCCTGCTTATCCTCCAGTGTTCTAC；ATTCGAAAATTTCCTATAGAATCGTATCTCTGGAGCCTGCTTATCCTCCAGTGTTCTACCTAAATAAAGATACAGGAGAGATTTATACAACCAGTGTTACCTTGGACAGAGAGGTAAG；CTAAATAAAGATACAGGAGAGATTTATACAACCAGTGTTACCTTGGACAGAGAGGTAAGTTAATATGTTATGTTGCCCATCTTTAAACTCTCTATCCTTTCCAGTTTCTCCTCTCTTT；TAAACTGGACTAAAACCAGAAAGCCAGATGTAAGAGTGACTCTTTTCACCCAGCTGGACATTTTTCATTGCTCTGCAGGAACACAGCAGCTACACTTTGACAGTAGAAGCAAGAGATG；ATTTTTCATTGCTCTGCAGGAACACAGCAGCTACACTTTGACAGTAGAAGCAAGAGATGGCAATGGAGAAGTTACAGACAAACCTGTAAAACAAGCTCAAGTTCAGATTCGTATTTTG；GCAATGGAGAAGTTACAGACAAACCTGTAAAACAAGCTCAAGTTCAGATTCGTATTTTGGATGTCAATGACAATATACCTGTAGTAGAAAATAAAGTGGTAACTATTATTCTTCTAAT；GATGTCAATGACAATATACCTGTAGTAGAAAATAAAGTGGTAACTATTATTCTTCTAATAACTGTACCTATTTATTTATATTTCAGTCCTAATTAAAAATATATCACTTATATTTGTA；TATTTATATTTCAGTCCTAATTAAAAATATATCACTTATATTTGTATTTCATTGAAATAAAAATCATGTGTTCATGTTTTGCAGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACG；AAAATCATGTGTTCATGTTTTGCAGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACGTAGAAGTTACGCGCATAAAAGTGTTCGATGCAGATGAAATAGGTTCTGATAATTGGCTG；TAGAAGTTACGCGCATAAAAGTGTTCGATGCAGATGAAATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGGAGGTTATTTCCACATAGAAACAGATGC；GCAAATTTTACATTTGCATCAGGAAATGAAGGAGGTTATTTCCACATAGAAACAGATGCTCAAACTAACGAAGGAATTGTGACCCTTATTAAGGTAAGTACTAAGTATTCAAAACTGG；TCAAACTAACGAAGGAATTGTGACCCTTATTAAGGTAAGTACTAAGTATTCAAAACTGGCGTGGGCCAAGTTGGTGCTGGAAAGGAATCTAATATATTTTGAGCCCTGAACACTTAAA；CACATGTATATGTATATGTATACATGTCTTCTGTTTTCTCTTTGAAAAGAATTCCCTTTGGTTTTCCCTTTCAGGAAGTAGATTATGAAGAAATGAAGAATCTTGACTTCAGTGTTAT；GGTTTTCCCTTTCAGGAAGTAGATTATGAAGAAATGAAGAATCTTGACTTCAGTGTTATTGTCGCTAATAAAGCAGCTTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCA；TGTCGCTAATAAAGCAGCTTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAAAGTGAAAAATGTGAAAGAAGGCATTCATTTTAAAAGCAGCGTC；TTCCCATCAAGGTCAAAGTGAAAAATGTGAAAGAAGGCATTCATTTTAAAAGCAGCGTCATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCAAATAATTGGAAA；ATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCAAATAATTGGAAATTTTCAAGCTTTTGATGAGGACACTGGACTACCAGCCCATGCAAGGTAAGAGAGAGTGA；TTTTCAAGCTTTTGATGAGGACACTGGACTACCAGCCCATGCAAGGTAAGAGAGAGTGACACGTGTATTTCTTTATTTTAAATTATTTTCAGTGCCTATTTTCAAAAATCATAATCAA；TTGAAAGAGCTGTAGATGTTAGAGGTTTCCAATTCATGCAGAATTCAAAATTAATTTTATGTTTGTTTTATGACAGATATGTAAAATTAGAAGATAGAGATAATTGGATCTCTGTGGA；TGTTTGTTTTATGACAGATATGTAAAATTAGAAGATAGAGATAATTGGATCTCTGTGGATTCTGTCACATCTGAAATTAAACTTGCAAAACTTCCTGATTTTGAATCTAGATATGTTC；TTCTGTCACATCTGAAATTAAACTTGCAAAACTTCCTGATTTTGAATCTAGATATGTTCAAAATGGCACATACACTGTAAAGATTGTGGCCATATCAGAAGGTAAGTTATTAAATAGA；AAAATGGCACATACACTGTAAAGATTGTGGCCATATCAGAAGGTAAGTTATTAAATAGATCTTTTTCTTGATTATATGTATTTAGATTTTTATTTTCCAACATCAGAAACCATTGATT；AAACTATGTCTGTTGTCAGCAATAGGAACAGAATGTACATACTTTTTCTCTCTTATTTTTAAGATTATCCTAGAAAAACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAA；TAAGATTATCCTAGAAAAACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCACACTGATAGAGCCTGTGCAGACAATCTGTCACGATGCAGAGTATG；CGACAACTGTCCCACACTGATAGAGCCTGTGCAGACAATCTGTCACGATGCAGAGTATGTGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCCTTTCAGTTTCTCC；TGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCCTTTCAGTTTCTCCGTCATTGACAAACCACCTGGCATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTAA；GTCATTGACAAACCACCTGGCATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTAAGCAAAATCACTGGACTACATAGAAATCTAAATATTAAGCATGATATCTAAAATATTTGT；TTAATGTTGCCTCATCCTTGGTAATCGTTCGTTTTTATTTCCTTCTGCCTCCCAACCTTGTAGGTACCAGTGTGCTGCTGCAACAAAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCA；GTAGGTACCAGTGTGCTGCTGCAACAAAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCAGTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACTCA；GTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACTCACAGTTTGTGAGTGTCTGCATGGCAGCGGCTGCAGGGAAGCACAGCATGACTCCTATGTG；CAGTTTGTGAGTGTCTGCATGGCAGCGGCTGCAGGGAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCATGATTTTGGCCTTTCTGCTCCTGCTATGTAA；GGCCTGGGACCCGCAGCAATTGCGCTCATGATTTTGGCCTTTCTGCTCCTGCTATGTAAGTCTTTAAAAGCCACTCTGTTGTGCTTTTGGGAATCTGAGTGCACTCCTGGAGATGTGT；GACATGCAAATTCCAAAATTGTGCAATATAAATTTAGAAATATATCAAGGTTAACCTTATCTGTGTTCAATTTTGTGTCTGTACAGTGGTACCACTTTTACTGCTGATGTGCCATTGC；TCTGTGTTCAATTTTGTGTCTGTACAGTGGTACCACTTTTACTGCTGATGTGCCATTGCGGAAAGGGCGCCAAAGGCTTTACCCCCATACCTGGCACCATAGAGATGCTGCATCCTTG；GGAAAGGGCGCCAAAGGCTTTACCCCCATACCTGGCACCATAGAGATGCTGCATCCTTGGAATAATGAAGGAGCACCACCTGAAGACAAGGTCAGTGGATCAGATGTCAATATGACTT；GAATAATGAAGGAGCACCACCTGAAGACAAGGTCAGTGGATCAGATGTCAATATGACTTGTCTTCTTCTTGGGTTTTAAAGGGGCCTAGGGAAGTGTTTCTTACATGTTTGGTTGAGT；TCCTTCTACCAAGGATGAAGGATTCCCTCCATCCTCCTGACTCAGTTCTCAGCTGTGTTTGCTCTCACAGGTGGTGCCATCATTTCTGCCAGTGGATCAAGGGGGCAGTCTAGTAGGA；TGCTCTCACAGGTGGTGCCATCATTTCTGCCAGTGGATCAAGGGGGCAGTCTAGTAGGAAGAAATGGAGTAGGAGGTATGGCCAAGGAAGCCACGATGAAAGGAAGTAGCTCTGCTTC；AGAAATGGAGTAGGAGGTATGGCCAAGGAAGCCACGATGAAAGGAAGTAGCTCTGCTTCCATTGTCAAAGGGCAACATGAGATGTCCGAGATGGATGGAAGGTGGGAAGAACACAGAA；CATTGTCAAAGGGCAACATGAGATGTCCGAGATGGATGGAAGGTGGGAAGAACACAGAAGCCTGCTTTCTGGTAGAGCTACCCAGTTTACAGGGGCCACAGGCGCTATCATGACCACT；GCCTGCTTTCTGGTAGAGCTACCCAGTTTACAGGGGCCACAGGCGCTATCATGACCACTGAAACCACGAAGACCGCAAGGGCCACAGGGGCTTCCAGAGACATGGCCGGAGCTCAGGC；GAAACCACGAAGACCGCAAGGGCCACAGGGGCTTCCAGAGACATGGCCGGAGCTCAGGCAGCTGCTGTTGCACTGAACGAAGAATTCTTAAGAAATTATTTCACTGATGTAAGGATGA；AGCTGCTGTTGCACTGAACGAAGAATTCTTAAGAAATTATTTCACTGATGTAAGGATGAGTTTTATGTATTGGTGGTGGGGGGTGGGGGGAACATTTGTATGTGAATGTGATATTATT；TGTTTGTTTTGTTTTGTTTTCATTTTAGAAAGCGGCCTCTTACACTGAGGAAGATGAAAATCACACAGCCAAAGATTGCCTTCTGGTTTATTCTCAGGAAGAAACTGAATCGCTGAAT；AAATCACACAGCCAAAGATTGCCTTCTGGTTTATTCTCAGGAAGAAACTGAATCGCTGAATGCTTCTATTGGTTGTTGCAGTTTTATTGAAGGAGAGCTAGATGACCGCTTCTTAGAT；GAATGCTTCTATTGGTTGTTGCAGTTTTATTGAAGGAGAGCTAGATGACCGCTTCTTAGATGATTTGGGACTTAAATTCAAGACACTAGCTGAAGTTTGCCTGGGTCAAAAAATAGAT；AGATGATTTGGGACTTAAATTCAAGACACTAGCTGAAGTTTGCCTGGGTCAAAAAATAGATATAAATAAGGAAATTGAGCAGAGACAAAAACCTGCCACAGAAACAAGTATGAACACA；AGATATAAATAAGGAAATTGAGCAGAGACAAAAACCTGCCACAGAAACAAGTATGAACACAGCTTCACATTCACTCTGTGAGCAAACTATGGTTAATTCAGAGAATACCTACTCCTCT；CACAGCTTCACATTCACTCTGTGAGCAAACTATGGTTAATTCAGAGAATACCTACTCCTCTGGCAGTAGCTTCCCAGTTCCAAAATCTTTGCAAGAAGCCAATGCAGAGAAAGTAACT；CTCTGGCAGTAGCTTCCCAGTTCCAAAATCTTTGCAAGAAGCCAATGCAGAGAAAGTAACTCAGGAAATAGTCACTGAAAGATCTGTGTCTTCTAGGCAGGCGCAAAAGGTAGCTACA；AACTCAGGAAATAGTCACTGAAAGATCTGTGTCTTCTAGGCAGGCGCAAAAGGTAGCTACACCTCTTCCTGACCCAATGGCTTCTAGAAATGTGATAGCAACAGAAACTTCCTATGTC；TACACCTCTTCCTGACCCAATGGCTTCTAGAAATGTGATAGCAACAGAAACTTCCTATGTCACAGGGTCCACTATGCCACCAACCACTGTGATCCTGGGTCCTAGCCAGCCACAGAGC；TGTCACAGGGTCCACTATGCCACCAACCACTGTGATCCTGGGTCCTAGCCAGCCACAGAGCCTTATTGTGACAGAGAGGGTGTATGCTCCAGCTTCTACCTTGGTAGATCAGCCTTAT；GAGCCTTATTGTGACAGAGAGGGTGTATGCTCCAGCTTCTACCTTGGTAGATCAGCCTTATGCTAATGAAGGTACAGTTGTGGTCACTGAAAGAGTAATACAGCCTCATGGGGGTGGA；TTATGCTAATGAAGGTACAGTTGTGGTCACTGAAAGAGTAATACAGCCTCATGGGGGTGGATCGAATCCTCTGGAAGGCACTCAGCATCTTCAAGATGTACCTTACGTCATGGTGAGG；TGGATCGAATCCTCTGGAAGGCACTCAGCATCTTCAAGATGTACCTTACGTCATGGTGAGGGAAAGAGAGAGCTTCCTTGCCCCCAGCTCAGGTGTGCAGCCTACTCTGGCCATGCCT；GAGGGAAAGAGAGAGCTTCCTTGCCCCCAGCTCAGGTGTGCAGCCTACTCTGGCCATGCCTAATATAGCAGTAGGACAGAATGTGACAGTGACAGAAAGAGTTCTAGCACCTGCTTCC；GCCTAATATAGCAGTAGGACAGAATGTGACAGTGACAGAAAGAGTTCTAGCACCTGCTTCCACTCTGCAATCCAGTTACCAGATTCCCACTGAAAATTCTATGACGGCTAGGAACACC；TTCCACTCTGCAATCCAGTTACCAGATTCCCACTGAAAATTCTATGACGGCTAGGAACACCACGGTGTCTGGAGCTGGAGTCCCTGGCCCTCTGCCAGATTTTGGTTTAGAGGAATCT；CACCACGGTGTCTGGAGCTGGAGTCCCTGGCCCTCTGCCAGATTTTGGTTTAGAGGAATCTGGTCATTCTAATTCTACCATAACCACATCTTCCACCAGAGTTACCAAGCATAGCACT；ATCTGGTCATTCTAATTCTACCATAACCACATCTTCCACCAGAGTTACCAAGCATAGCACTGTACAGCATTCTTACTCCTAAACAGCAGTCAGCCACAAACTGACCCAGAGTTTAATT；CACTGTACAGCATTCTTACTCCTAAACAGCAGTCAGCCACAAACTGACCCAGAGTTTAATTAGCAGTGACTAATTTCATGTTTCCAATGTACCTGATTTTTCATGAGCCTTACAGACA；
所述探针组9由如下核酸分子组成：
CGCCCGCCAGCCTCGCCCGCGCCGTCACCATGAGCCAGGCCTACTCGTCCAGCCAGCGCGTGTCCTCCTACCGCCGCACCTTCGGCGGGGCCCCGGGCTTCCCACTCGGCTCCCCGCT；CGTGTCCTCCTACCGCCGCACCTTCGGCGGGGCCCCGGGCTTCCCACTCGGCTCCCCGCTGAGTTCGCCCGTGTTCCCGCGGGCGGGTTTCGGCTCTAAGGGCTCCTCCAGCTCGGTG；CTGAGTTCGCCCGTGTTCCCGCGGGCGGGTTTCGGCTCTAAGGGCTCCTCCAGCTCGGTGACGTCCCGCGTGTACCAGGTGTCGCGCACGTCGGGCGGGGCCGGGGGCCTGGGGTCGC；TGCGGGCCAGCCGGCTGGGGACCACCCGCACGCCCTCCTCCTACGGCGCAGGCGAGCTGCTGGACTTCTCACTGGCCGACGCGGTGAACCAGGAGTTTCTGACCACGCGCACCAACGA；CTGGACTTCTCACTGGCCGACGCGGTGAACCAGGAGTTTCTGACCACGCGCACCAACGAGAAGGTGGAGCTGCAGGAGCTCAATGACCGCTTCGCCAACTACATCGAGAAGGTGCGCT；GAAGGTGGAGCTGCAGGAGCTCAATGACCGCTTCGCCAACTACATCGAGAAGGTGCGCTTCCTGGAGCAGCAGAACGCGGCGCTCGCCGCCGAAGTGAACCGGCTCAAGGGCCGCGAG；TCCTGGAGCAGCAGAACGCGGCGCTCGCCGCCGAAGTGAACCGGCTCAAGGGCCGCGAGCCGACGCGAGTGGCCGAGCTCTACGAGGAGGAGCTGCGGGAGCTGCGGCGCCAGGTGGA；CCGACGCGAGTGGCCGAGCTCTACGAGGAGGAGCTGCGGGAGCTGCGGCGCCAGGTGGAGGTGCTCACTAACCAGCGCGCGCGCGTCGACGTCGAGCGCGACAACCTGCTCGACGACC；GGTGCTCACTAACCAGCGCGCGCGCGTCGACGTCGAGCGCGACAACCTGCTCGACGACCTGCAGCGGCTCAAGGCCAAGTGAGGGCCCGGCACCCCAGACTCCTCTTTCTGCGGGCAG；TGCAGCGGCTCAAGGCCAAGTGAGGGCCCGGCACCCCAGACTCCTCTTTCTGCGGGCAGGGCACAGGAGGCTAGGCCTGGGGTCTGGGGTCCCGCTGTCAGCACCTGCCTTCTCCCGG；ACCCACCCCCTGGTCAGCCCCCGGCCAGTCGTTTCCACTGCCAGCTTTATCACCCGCAACTGTCTGTCTTTCTGTCTGTCCCACCCAGGCTGCAGGAGGAGATTCAGTTGAAGGAAGA；CTGTCTGTCTTTCTGTCTGTCCCACCCAGGCTGCAGGAGGAGATTCAGTTGAAGGAAGAAGCAGAGAACAATTTGGCTGCCTTCCGAGCGGTGAGTGCCCTTCTTTTCCCCTTGCATG；AGCAGAGAACAATTTGGCTGCCTTCCGAGCGGTGAGTGCCCTTCTTTTCCCCTTGCATGGCCTCTGGCCTTGCTCTGCCCCACCTGGGTGGCGGTGACCATGTCCTTCTCGCTTGGCC；ATGGCCTCTGGCCTTGCTCTGCCCCACCTGGGTGGCGGTGACCATGTCCTTCTCGCTTGGCCTCTCCCAGGACGTGGATGCAGCTACTCTAGCTCGCATTGACCTGGAGCGCAGAATT；GCCTCTCCCAGGACGTGGATGCAGCTACTCTAGCTCGCATTGACCTGGAGCGCAGAATTGAATCTCTCAACGAGGAGATCGCGTTCCTTAAGAAAGTGCATGAAGAGGTATACCTTGG；GAATCTCTCAACGAGGAGATCGCGTTCCTTAAGAAAGTGCATGAAGAGGTATACCTTGGCCCCTCTTCCTGGGGTCACTGGGCCATGGGGAAAGCAGCCGGAAAGTGGGGTTGGGGTG；GGAATAGGGGTGTGAGGGTGCTGTGTGGGCCCTGAGAGGGGACTGAAGCCCAGTCATGCCCTACAGGAGATCCGTGAGTTGCAGGCTCAGCTTCAGGAACAGCAGGTCCAGGTGGAGA；CCTACAGGAGATCCGTGAGTTGCAGGCTCAGCTTCAGGAACAGCAGGTCCAGGTGGAGATGGACATGTCTAAGCCAGACCTCACTGCCGCCCTCAGGGACATCCGGGCTCAGTATGAG；TGGACATGTCTAAGCCAGACCTCACTGCCGCCCTCAGGGACATCCGGGCTCAGTATGAGACCATCGCGGCTAAGAACATTTCTGAAGCTGAGGAGTGGTACAAGTCGAAGGTGGGTGG；ACCATCGCGGCTAAGAACATTTCTGAAGCTGAGGAGTGGTACAAGTCGAAGGTGGGTGGCCTCGCCCGGGGACTGGCATCTCCGTCCCCCTGAATCCCAGCTTGGATGTGCTGCCTGT；TGCCTGTGGTACCATCCATGGGAGGAGAGCCCAGAGGCTTCATGCTCCCTTGCTCATCCCTACCCGTGCCCTGCATCCTTCTCATTTTTGGGCCCCTTTCTCTGCCCTTAGGTGTCAG；CTACCCGTGCCCTGCATCCTTCTCATTTTTGGGCCCCTTTCTCTGCCCTTAGGTGTCAGACCTGACCCAGGCAGCCAACAAGAACAACGACGCCCTGCGCCAGGCCAAGCAGGAGATG；ACCTGACCCAGGCAGCCAACAAGAACAACGACGCCCTGCGCCAGGCCAAGCAGGAGATGATGGAATACCGACACCAGATCCAGTCCTACACCTGCGAGATTGACGCCCTGAAGGGCAC；ATGGAATACCGACACCAGATCCAGTCCTACACCTGCGAGATTGACGCCCTGAAGGGCACTGTGAGTCCCTGCCCACCTGGCCAGGCCCTGCCCCTTCCTGTCTGCAGTTCACACCCT；CCAAAGCTTTCTTTGGGCTGCTAGTGTCCTCTTCCCTTCCTTGACCTGGGTTCCCCCTCTCCTGCAGAACGATTCCCTGATGAGGCAGATGCGGGAATTGGAGGACCGATTTGCCAGT；TCCTGCAGAACGATTCCCTGATGAGGCAGATGCGGGAATTGGAGGACCGATTTGCCAGTGAGGCCAGTGGCTACCAGGACAACATTGCGCGCCTGGAGGAGGAAATCCGGCACCTCAA；GAGGCCAGTGGCTACCAGGACAACATTGCGCGCCTGGAGGAGGAAATCCGGCACCTCAAGGATGAGATGGCCCGCCATCTGCGCGAGTACCAGGACCTGCTCAACGTGAAGATGGCCC；GGATGAGATGGCCCGCCATCTGCGCGAGTACCAGGACCTGCTCAACGTGAAGATGGCCCTGGATGTGGAGATTGCCACCTACCGGAAGCTGCTGGAGGGAGAGGAGAGCCGGTGAGGG；TGGATGTGGAGATTGCCACCTACCGGAAGCTGCTGGAGGGAGAGGAGAGCCGGTGAGGGGCCAGGCAGGAGCCCGAGTGGGAGGTGCGGGGTGCTGGGTGGTCCATTTCTGTCCCCAG；ATTACAGCTGGGCCCGGCCGATGGGAGGGTTCTTAACTCTTAGGAGGTTTTGTCTCTTCCCTTTTAGGATCAATCTCCCCATCCAGACCTACTCTGCCCTCAACTTCCGAGGTGAGTG；CCTTTTAGGATCAATCTCCCCATCCAGACCTACTCTGCCCTCAACTTCCGAGGTGAGTGTCTGCTGGCAGGCGGAGGCTGGAGTTGCAGGGGCCAGGAGTCCAGCATGGGCACTGCCC；CCAGATGGACTCCCAGCCCCTGGTATAGCCCAGCCTGGACTTGGTCAGGCTGAGTGTGCGATGGACCCTGTTACAGAAACCAGCCCTGAGCAAAGGGGTTCTGAGGTCCATACCAAGA；GATGGACCCTGTTACAGAAACCAGCCCTGAGCAAAGGGGTTCTGAGGTCCATACCAAGAAGACGGTGATGATCAAGACCATCGAGACACGGGATGGGGAGGTAAGTGGTCTGTCTGGG；AGACGGTGATGATCAAGACCATCGAGACACGGGATGGGGAGGTAAGTGGTCTGTCTGGGCTCCTTACCCTTGGTGGGGGCTATGGATGTGTCTGGGGGGACTGTCTTCCACCCAGCTG；GGTGGGGATGGCTCAGGGCTGAGGCTCCATTCTCTGGCTAGCACATGGTTGGACTGGGCTTCTCTTCCTCCCCAGGTCGTCAGTGAGGCCACACAGCAGCAGCATGAAGTGCTCTAAA；TTCTCTTCCTCCCCAGGTCGTCAGTGAGGCCACACAGCAGCAGCATGAAGTGCTCTAAAGACAGAGACCCTCTGCCACCAGAGACCGTCCTCACCCCTGTCCTCACTGCTCCCTGAAG；
所述探针组10由如下核酸分子组成：
GCTGGCAAGAGGCCGCTGGACACCACGCTCCAGTCGTCAGCCCACTTCCTAGCTGAACAGCGCGAGGCGGCGGCAGCGAGCCGGGTCCCACCATGGCCGCGAATGTGAGTATCCCCGG；GCGCGAGGCGGCGGCAGCGAGCCGGGTCCCACCATGGCCGCGAATGTGAGTATCCCCGGGCCAGCCGGGCCACACCCAGGCTTCCCCGTCGCCCTGGGGCTTTTCCCCGGGGTCCTCT；TATAAATAAATAGCAAATTTAATTTATTTTTAAAAACTAGTTTTCATTCTGTTACTGTTTCTTTTTCTTCAGTATTCCAGTACCAGTACCCGGAGAGAACATGTCAAAGTTAAAACCA；TCTTTTTCTTCAGTATTCCAGTACCAGTACCCGGAGAGAACATGTCAAAGTTAAAACCAGCTCCCAGCCAGGCTTCCTGGAACGGCTGAGCGAGACCTCGGGTGGGATGTTTGTGGGG；GCTCCCAGCCAGGCTTCCTGGAACGGCTGAGCGAGACCTCGGGTGGGATGTTTGTGGGGCTCATGGCCTTCCTGCTCTCCTTCTACCTAATTTTCACCAATGAGGTAAAATGTCTGGG；CTCATGGCCTTCCTGCTCTCCTTCTACCTAATTTTCACCAATGAGGTAAAATGTCTGGGGTCTTCCTGTGCAGAGTGAGAGTCCCCACCATGTCAGAGAGCAAAGGCGATGAACCCGG；CATCCTACCCTAATACTTTGCAACAAGCACAGTCATGCTGAGCCACCCCTGAGCTGTTGAAATCCCCACTCCCCTTTGCTCCCAGGGCCGCGCATTGAAGACGGCAACCTCATTGGCT；AAATCCCCACTCCCCTTTGCTCCCAGGGCCGCGCATTGAAGACGGCAACCTCATTGGCTGAGGGGCTCTCGCTTGTGGTGTCTCCCGACAGCATCCACAGTGTGGCTCCGGAGAATGA；GAGGGGCTCTCGCTTGTGGTGTCTCCCGACAGCATCCACAGTGTGGCTCCGGAGAATGAAGGAAGGCTGGTGCACATCATTGGCGCCTTACGGACATCCAAGGTAGGTTTGGCAGGGG；AGGAAGGCTGGTGCACATCATTGGCGCCTTACGGACATCCAAGGTAGGTTTGGCAGGGGATGCTGACCTGCCAGTGGCTCGGGGCTCATCCTGGATGTTGTCTGGCTGAGGATTTGA；TGAGCCAGGCTTTCTGGGCTGACGTGAATGTTATCCTTTATTTTTTTGGTTTCTTTGATTCTGTTTGAAGCTTTTGTCTGATCCAAACTATGGGGTCCATCTTCCGGCTGTGAAACTG；TCTGTTTGAAGCTTTTGTCTGATCCAAACTATGGGGTCCATCTTCCGGCTGTGAAACTGCGGAGGCACGTGGAGATGTACCAATGGGTAGAAACTGAGGAGTCCAGGTGAGCTGTTGG；CGGAGGCACGTGGAGATGTACCAATGGGTAGAAACTGAGGAGTCCAGGTGAGCTGTTGGGGTGAAAACTCTGTTGGGGTAAAGGAGGAGTGAAGTGTAGGTGTCAGGATAACATGCAG；CTTAGAGATTAGACTGCCTGGGGCGACGAGGCTAACCCCCGTGGCTGCTTTGCTTTCCCTGCAGGGAGTACACCGAGGATGGGCAGGTGAAGAAGGAGACGAGGTATTCCTACAGTGA；TGCAGGGAGTACACCGAGGATGGGCAGGTGAAGAAGGAGACGAGGTATTCCTACAGTGAGTGCTGGGCCCCTTACGTGGTCTCTGCCCATGGTGGGGGCCCACAGTGGTGGCTGGACA；CCCTTTGGCTGTGAGATAGGAGGAGCTGGGCTGGTGGGTCTCAGCCGCGTGCCACTCCTACCCGGGCTCTGAGTTGATTCCTCTCCCTGAGCAGACACTGAATGGAGGTCAGAAATCA；ACCCGGGCTCTGAGTTGATTCCTCTCCCTGAGCAGACACTGAATGGAGGTCAGAAATCATCAACAGCAAAAACTTCGACCGAGAGATTGGCCACAAAAACCCCAGGTGAGAGCCAGGC；TCAACAGCAAAAACTTCGACCGAGAGATTGGCCACAAAAACCCCAGGTGAGAGCCAGGCCCAAGGCCTGAGTGCAGCTTTGTCTACACTGGCAGGTCTCCAGCCTCAGTTTCTTCAT；CCTGCCCAGCACAAACAACCCAAAGGGACCCGGGCAGCTCCCACACCGGTGCCCATCTCTGACAGCTTCCTCTCTCCCACAGTGCCATGGCAGTGGAGTCATTCATGGCAACAGCCCC；TGACAGCTTCCTCTCTCCCACAGTGCCATGGCAGTGGAGTCATTCATGGCAACAGCCCCCTTTGTCCAAATTGGCAGGTTTTTCCTCTCGTCAGGTAAGTCTCAGGCCTCTCCAGAGG；CTTTGTCCAAATTGGCAGGTTTTTCCTCTCGTCAGGTAAGTCTCAGGCCTCTCCAGAGGAGCTCGTGCCAGAAGCACAAGGCCCCCCTAGGGCCGGAGCTCCCAGTACTCAGCCTTCA；GCAGTGGAAGGGGGTCAGGCCAGGGACTTTGCAGATTGAGGTTTTCACCTGGTCCCCTGGGTTTCTAACCACTCTGGTCCCCTCAGGCCTCATCGACAAAGTCGACAACTTCAAGTCC；GGTTTCTAACCACTCTGGTCCCCTCAGGCCTCATCGACAAAGTCGACAACTTCAAGTCCCTGAGCCTATCCAAGCTGGAGGACCCTCATGTGGACATCATTCGCCGTGGAGACTTTTT；CTGAGCCTATCCAAGCTGGAGGACCCTCATGTGGACATCATTCGCCGTGGAGACTTTTTCTACCACAGCGAAAATCCCAAGTATCCAGAGGTGTGCGGAGAGGCCTGGGCTCTCCAAA；CTACCACAGCGAAAATCCCAAGTATCCAGAGGTGTGCGGAGAGGCCTGGGCTCTCCAAATAGGAGGGTCAGGGCGCTAGGATCAGGTTCCTGCGCCAGGCAGATTCAGTTCAGTCGCA；GGCGTAGCCGAGGCATCCTGGACCTGGGCCTGGGCCAGCTACTCCGTTCCTCACTCTCCCTGCTTCTCTTCCACCCCCAGGTGGGAGACTTGCGTGTCTCCTTTTCCTATGCTGGACT；CTGCTTCTCTTCCACCCCCAGGTGGGAGACTTGCGTGTCTCCTTTTCCTATGCTGGACTGAGCGGCGATGACCCTGACCTGGGCCCAGCTCACGTGGTAACCTGGCTTCCCAGGGGCA；GAGCGGCGATGACCCTGACCTGGGCCCAGCTCACGTGGTAACCTGGCTTCCCAGGGGCAGACACTAAGTCAGAGCCTCACGACTTTCCTGGACACAGACACCTTGGTCAATGTCAGGA；CCATGGCTCTCGTGGGCGTGTCTCCCGCTGGTCACCCCTCAGCTCTAACACCAGGTCCTCTGACCAGGTCACTGTGATTGCCCGGCAGCGGGGTGACCAGCTAGTCCCATTCTCCACC；CTGACCAGGTCACTGTGATTGCCCGGCAGCGGGGTGACCAGCTAGTCCCATTCTCCACCAAGTCTGGGGATACCTTACTGCTCCTGCACCACGGGGACTTCTCAGCAGAGGTGAGTGC；AAGTCTGGGGATACCTTACTGCTCCTGCACCACGGGGACTTCTCAGCAGAGGTGAGTGCTGTGCCCTACTCGTACGGTGGAGGAACAAGCATGTCCTTCCTTCCTTCCAGTGGTTATT；GTTGGTACAGCCCCCTCAGGACCTGCCCTGCCGACTGGGTACGCCACTGGCCCTCAGCATCCTGACCTGCCCCCACCTTGTCCTGCAGGAGGTGTTTCATAGAGAACTAAGGAGCAAC；TCCTGACCTGCCCCCACCTTGTCCTGCAGGAGGTGTTTCATAGAGAACTAAGGAGCAACTCCATGAAGACCTGGGGCCTGCGGGCAGCTGGCTGGATGGCCATGTTCATGGGCCTCAA；TCCATGAAGACCTGGGGCCTGCGGGCAGCTGGCTGGATGGCCATGTTCATGGGCCTCAACCTTATGACACGGATCCTCTACACCTTGGGTAGGTGTTGGGGTGGGTCACTGCCCTCCC；CCTTATGACACGGATCCTCTACACCTTGGGTAGGTGTTGGGGTGGGTCACTGCCCTCCCTCCTGCACCCTGAAAGGGCCTCCTCTGCCTGTCGCATCATCTCAGCCCTTCCAGCCTGA；TCTAGGGACAGGAGAGATCTGCTGAGCTGGTGAGGTGTAGAGCAGGTGGCACCTCATCACCTTTCTCCTTTCCACAGTGGACTGGTTTCCTGTTTTCCGAGACCTGGTCAACATTGGC；CCTTTCTCCTTTCCACAGTGGACTGGTTTCCTGTTTTCCGAGACCTGGTCAACATTGGCCTGAAAGCCTTTGCCTTCTGTGTGGCCACCTCGCTGACCCTGCTGACCGTGGCGGCTGG；CTGAAAGCCTTTGCCTTCTGTGTGGCCACCTCGCTGACCCTGCTGACCGTGGCGGCTGGCTGGCTCTTCTACCGACCCCTGTGGGCCCTCCTCATTGCCGGCCTGGCCCTTGTGCCCA；CTGGCTCTTCTACCGACCCCTGTGGGCCCTCCTCATTGCCGGCCTGGCCCTTGTGCCCATCCTTGTTGCTCGGACACGGGTGCCAGCCAAAAAGTTGGAGTGAAAAGACCCTGGCACC；TCCTTGTTGCTCGGACACGGGTGCCAGCCAAAAAGTTGGAGTGAAAAGACCCTGGCACCCGCCCGACACCTGCGTGAGCCCTAGGATCCAGGTCCTCTCTCACCTCTGACCCAGCTCC；
所述探针组11由如下核酸分子组成：
ACTCCCGCCCGGTTCCCCGGCCGTCCGCCTATCCTTGGCCCCCTCCGCTTTCTCCGCGCCGGCCCGCCTCGCTTATGCCTCGGCGCTGAGCCGCTCTCCCGATTGCCCGCCGACATGA；CGGCCCGCCTCGCTTATGCCTCGGCGCTGAGCCGCTCTCCCGATTGCCCGCCGACATGAGCTGCAACGGAGGCTCCCACCCGCGGATCAACACTCTGGGCCGCATGATCCGCGCCGAG；GCTGCAACGGAGGCTCCCACCCGCGGATCAACACTCTGGGCCGCATGATCCGCGCCGAGTCTGGCCCGGACCTGCGCTACGAGGTGACCAGCGGCGGCGGGGGCACCAGCAGGATGTA；TCTGGCCCGGACCTGCGCTACGAGGTGACCAGCGGCGGCGGGGGCACCAGCAGGATGTACTATTCTCGGCGCGGCGTGATCACCGACCAGAACTCGGACGGCTACTGGTGGGTACCTG；CTATTCTCGGCGCGGCGTGATCACCGACCAGAACTCGGACGGCTACTGGTGGGTACCTGCCCGGAGAGCGCGGGCTGCGGGGCTCGCGGGACAGGGAGGGACCGTCCTCCTCTGGACG；AATTGAAATAGGTTATTTGATGTCTGGTTTCTCTGTGTTTGCCTCCTTAGTCAAACCGGCACGATGTCCAGGCACCAGAACCAGAACACCATCCAGGAGCTGCTGCAGAACTGCTCCG；CACGATGTCCAGGCACCAGAACCAGAACACCATCCAGGAGCTGCTGCAGAACTGCTCCGACTGCTTGATGCGAGCAGAGCTCATCGTGCAGCCTGTAAGCTTTCCCTGTTCCCATCGC；ACTGCTTGATGCGAGCAGAGCTCATCGTGCAGCCTGTAAGCTTTCCCTGTTCCCATCGCTTCTCCCAAAGCCTTGGCCACACCCGACTGTCCTCTGGTTAGCTTCTGCTGGCCGGGGC；TGCTTCCATTAATGCCCATGAAGGTTTTCTTCCTGGTAGTATGTGTTTTCCTTCATGTGAGTGTTTTCTTTCAGGAATTGAAGTATGGAGATGGAATACAACTGACTCGGAGTCGAGA；AGTGTTTTCTTTCAGGAATTGAAGTATGGAGATGGAATACAACTGACTCGGAGTCGAGAATTGGATGAGTGTTTTGCCCAGGCCAATGACCAAATGGAAATCCTCGACAGCTTGATCA；ATTGGATGAGTGTTTTGCCCAGGCCAATGACCAAATGGAAATCCTCGACAGCTTGATCAGAGAGATGCGGCAGATGGGCCAGCCCTGTGATGCTTACCAGAAAAGGTATTGTCCACAG；GAGAGATGCGGCAGATGGGCCAGCCCTGTGATGCTTACCAGAAAAGGTATTGTCCACAGAGCATGGATCGGGCAGTCCCCATGAAAAAGAACACCACATAACCAGTTACACTCAATTC；CCAGAACGGGTTTTCATAGGCTGTTTTCCTGCAGTGGTTTAAAGGTTTTTTTCTTTGCAGGCTTCTTCAGCTCCAAGAGCAAATGCGAGCCCTTTATAAAGCCATCAGTGTCCCTCGA；GGCTTCTTCAGCTCCAAGAGCAAATGCGAGCCCTTTATAAAGCCATCAGTGTCCCTCGAGTCCGCAGGGCCAGCTCCAAGGGTGGTGGAGGCTACACTTGTCAGAGTGGCTCTGGCTG；GTCCGCAGGGCCAGCTCCAAGGGTGGTGGAGGCTACACTTGTCAGAGTGGCTCTGGCTGGGATGAGTTCACCAAACATGTCACCAGTGAATGTTTGGGGTGGATGAGGCAGCAAAGGG；GGATGAGTTCACCAAACATGTCACCAGTGAATGTTTGGGGTGGATGAGGCAGCAAAGGGTAAGCAGCTTCTTGAACAGCCCAAACCTGTGCAGGCCAGACGTTCCAGCACGATGGGGT；AGTAAAGCCGTGATGGTGTGCGTAAGTGAAACAGGTGCAAAGGGGCAACAACAAAGGGCGCCTCTCTTTGTCTTTGTGTCGCAGGCGGAGATGGACATGGTGGCCTGGGGTGTGGACC；GCCTCTCTTTGTCTTTGTGTCGCAGGCGGAGATGGACATGGTGGCCTGGGGTGTGGACCTGGCCTCAGTGGAGCAGCACATTAACAGCCACCGGGGCATCCACAACTCCATCGGCGAC；TGGCCTCAGTGGAGCAGCACATTAACAGCCACCGGGGCATCCACAACTCCATCGGCGACTATCGCTGGCAGCTGGACAAAATCAAAGCCGACCTGGTACTTGTCTGTGTTTCATTTTA；TATCGCTGGCAGCTGGACAAAATCAAAGCCGACCTGGTACTTGTCTGTGTTTCATTTTAGAGTCTTCAAAATATCTACCGAAGGATCGTGTAATTACTCAATCCCAGGGAGTTTCTTC；CCACTCTTTTCTATACAATCCACAAGGGGATTTATATCTACCTGCTTTTTGTTGTCTTCTAGCGCGAGAAATCTGCTATCTACCAGTTGGAGGAGGAGTATGAAAACCTGCTGGTAAG；TAGCGCGAGAAATCTGCTATCTACCAGTTGGAGGAGGAGTATGAAAACCTGCTGGTAAGCTGATTTATTTCTCAAGTGCATCGACTTTCTGTTGTTTCCAATTCAATTCAGTTCAAGA；AACCTGCAGAGAACACCAGTCACTGCATATTGTTATTTTAATGCTGCCTTTGAACCTCCTGTGCAGAAAGCGTCCTTTGAGAGGATGGATCACCTGCGACAGCTGCAGAACATCATTC；TGTGCAGAAAGCGTCCTTTGAGAGGATGGATCACCTGCGACAGCTGCAGAACATCATTCAGGCCACGTCCAGGGAGATCATGTGGATCAATGACTGCGAGGAGGAGGAGCTGCTGTAC；AGGCCACGTCCAGGGAGATCATGTGGATCAATGACTGCGAGGAGGAGGAGCTGCTGTACGACTGGAGCGACAAGAACACCAACATCGCTCAGAAACAGGAGGCCTTCTCCGTAAGTTC；GACTGGAGCGACAAGAACACCAACATCGCTCAGAAACAGGAGGCCTTCTCCGTAAGTTCACCCCACGCGGCTGTAGATGCTTGTCTTGAGCCTGTTGCCTTGAAGAGCTGGGGTCTCG；ACTGTGGGGGTGATGGAAGTTTAATGATGACTTGCTGCAAAGGATTTCTTATTTCTTCATTCACAGATACGCATGAGTCAACTGGAAGTTAAAGAAAAAGAGCTCAATAAGCTGAAAC；TTCACAGATACGCATGAGTCAACTGGAAGTTAAAGAAAAAGAGCTCAATAAGCTGAAACAAGAAAGTGACCAACTTGTCCTCAATCAGCATCCAGCTTCAGACAAAATTGAGGTAGGC；AAGAAAGTGACCAACTTGTCCTCAATCAGCATCCAGCTTCAGACAAAATTGAGGTAGGCTTCATGAGGTTTATATTTTTGTTAGAAAAAAAAAAACTTTTCATAAAGTAAGACTAACC；CCTATCTCTTGGTGTTCATGCATCTGTACAACTGAGCTAGGCTAAGACAGCTGACATTTTCTTGTTTCAGGCCTATATGGACACTCTGCAGACGCAGTGGAGTTGGATTCTTCAGATC；TCTTGTTTCAGGCCTATATGGACACTCTGCAGACGCAGTGGAGTTGGATTCTTCAGATCACCAAGTGCATTGATGTTCATCTGAAAGAAAATGCTGCCTACTTTCAGGTTTTTATATT；ACCAAGTGCATTGATGTTCATCTGAAAGAAAATGCTGCCTACTTTCAGGTTTTTATATTTAGTGATAATTTTGTTGTTATTTAGGTCTTAATACCTAATCTTTTGAGTGTGTTTTATA；GATGACAATCCTTGAAACAGAACTACTAGATGAAATTGCTCATTGAGTTGCTGTTCATTCACTGATCACTCTCATCCTTCACAGTTTTTTGAAGAGGCGCAGTCTACTGAAGCATACC；CACTGATCACTCTCATCCTTCACAGTTTTTTGAAGAGGCGCAGTCTACTGAAGCATACCTGAAGGGGCTCCAGGACTCCATCAGGAAGAAGTACCCCTGCGACAAGAACATGCCCCTG；TGAAGGGGCTCCAGGACTCCATCAGGAAGAAGTACCCCTGCGACAAGAACATGCCCCTGCAGCACCTGCTGGAACAGATCAAGGAGCTGGAGGTATCGTCTCAGACCCAGAACCTCAG；CAGCACCTGCTGGAACAGATCAAGGAGCTGGAGGTATCGTCTCAGACCCAGAACCTCAGCAGCTGTGCCTGATCAGGGAGATAAAACACATGCCTTGGATGCAGTTGGCTCTGATTAG；ATGCAGGTTGAAAATCTCCTCTAAAACTCACAGGGTATCTATGTTTAAGTATGATTTTATTCACCATTGCAGAAAGAACGAGAGAAAATCCTTGAATACAAGCGTCAGGTGCAGAACT；TTCACCATTGCAGAAAGAACGAGAGAAAATCCTTGAATACAAGCGTCAGGTGCAGAACTTGGTAAACAAGTCTAAGAAGATTGTACAGCTGAAGCCTCGTAACCCAGACTACAGAAGC；TGGTAAACAAGTCTAAGAAGATTGTACAGCTGAAGCCTCGTAACCCAGACTACAGAAGCAATAAACCCATTATTCTCAGAGCTCTCTGTGACTACAAACAAGATCAGGTGTGTACTCA；AATAAACCCATTATTCTCAGAGCTCTCTGTGACTACAAACAAGATCAGGTGTGTACTCATTTAGAATGATACAAAAGTTTTCCCTGTCTTTACACACAAATTTTTGTCCATCAAGAAA；ATCATTGAGAAAAAAAATAAAAACACATACTTATGAATAAAGCCAAACCCTGGGGTTGCTTGCCTTACAGAAAATCGTGCATAAGGGGGATGAGTGTATCCTGAAGGACAACAACGAG；TTGCCTTACAGAAAATCGTGCATAAGGGGGATGAGTGTATCCTGAAGGACAACAACGAGCGCAGCAAGTGGTACGTGACGGGCCCGGGAGGCGTTGACATGCTTGTTCCCTCTGTGGG；CGCAGCAAGTGGTACGTGACGGGCCCGGGAGGCGTTGACATGCTTGTTCCCTCTGTGGGGCTGATCATCCCTCCTCCGAACCCACTGGCCGTGGACCTCTCTTGCAAGTAAGTCATCC；GCTGATCATCCCTCCTCCGAACCCACTGGCCGTGGACCTCTCTTGCAAGTAAGTCATCCAAGTTCCCAAAGCCACGCATGCACGCATGAATGTGAGGGCAGAGGAAGAGGGCAGGTGT；AGTGGTGTGAGCGTGTCCAGGTTTCCCATTTGGGATGAAGTGTGAAAGCCTGGCTCTAGCATGTTTTCCCTTTGTGCCTCTTAGGATTGAGCAGTACTACGAAGCCATCTTGGCTCTG；CATGTTTTCCCTTTGTGCCTCTTAGGATTGAGCAGTACTACGAAGCCATCTTGGCTCTGTGGAACCAGCTCTACATCAACATGAAGAGCCTGGTGTCCTGGCACTACTGCATGATTGA；TGGAACCAGCTCTACATCAACATGAAGAGCCTGGTGTCCTGGCACTACTGCATGATTGACATAGAGAAGATCAGGGCCATGACAATCGCCAAGGTATGTCCTCAGGGCCACTTAGGCT；CATAGAGAAGATCAGGGCCATGACAATCGCCAAGGTATGTCCTCAGGGCCACTTAGGCTGCCTGGAGGGAGGGCAGCGCTGCCCCCCGCAGTGCCTGTGTCCAACAGTTCAACCTTCT；TTTTTTGGCCAACTCTTCTTGATTGCATTGTGGGGCAGTCATAAATCCCAAATCACTTCTGCCTGTCTCCTTTCAGCTGAAAACAATGCGGCAGGAAGATTACATGAAGACGATAGCC；TGCCTGTCTCCTTTCAGCTGAAAACAATGCGGCAGGAAGATTACATGAAGACGATAGCCGACCTTGAGTTACATTACCAAGAGTTCATCAGAAATAGCCAAGGCTCAGAGATGTTTGG；GACCTTGAGTTACATTACCAAGAGTTCATCAGAAATAGCCAAGGCTCAGAGATGTTTGGAGATGATGACAAGCGGAAAATACAGTCTCAGTTCACCGATGCCCAGAAGCATTACCAGA；AGATGATGACAAGCGGAAAATACAGTCTCAGTTCACCGATGCCCAGAAGCATTACCAGACCCTGGTCATTCAGCTCCCTGGCTATCCCCAGCACCAGACAGGTCGGCTTGGGACATCT；CCCTGGTCATTCAGCTCCCTGGCTATCCCCAGCACCAGACAGGTCGGCTTGGGACATCTTTCTCTTTGTATCAACCATCCATACCATTTTAAAAAGAAGGGAGTTTGCATAAAACTGG；GAGGCCTAGCACCTTGATACCTAGGTATTCTCTGATTTTTGTGGCCCTAACTTCTTTTTACAGTGACCACAACTGAAATCACTCATCATGGAACCTGCCAAGATGTCAACCATAATAA；ACAGTGACCACAACTGAAATCACTCATCATGGAACCTGCCAAGATGTCAACCATAATAAAGTAATTGAAACCAACAGAGAAAATGACAAGCAAGAAACATGGATGCTGATGGAGCTGC；AGTAATTGAAACCAACAGAGAAAATGACAAGCAAGAAACATGGATGCTGATGGAGCTGCAGAAGATTCGCAGGCAGATAGAGCACTGCGAGGGCAGGATGACTCTCAAAAACCTCCCT；AGAAGATTCGCAGGCAGATAGAGCACTGCGAGGGCAGGATGACTCTCAAAAACCTCCCTCTAGCAGACCAGGGATCTTCTCACCACATCACAGTGAAAATTAACGAGCTTAAGGTAGG；CTAGCAGACCAGGGATCTTCTCACCACATCACAGTGAAAATTAACGAGCTTAAGGTAGGTATCTGCTAGTATTTTGCCTGGTTACCCTGTATATTTTTATTTACCTGTAAATGAATAA；TTAAATATATACAGTAATAAAAAGAATCAGCTAAATCAAAAGAGCTTTCCTTCATTTTTGACAGAGTGTGCAGAATGATTCACAAGCAATTGCTGAGGTTCTCAACCAGCTTAAAGAT；GACAGAGTGTGCAGAATGATTCACAAGCAATTGCTGAGGTTCTCAACCAGCTTAAAGATATGCTTGCCAACTTCAGAGGTTCTGAAAAGTACTGCTATTTACAGAATGAAGTATTTGG；ATGCTTGCCAACTTCAGAGGTTCTGAAAAGTACTGCTATTTACAGAATGAAGTATTTGGACTATTTCAGAAACTGGAAAATATCAATGGTGTTACAGATGGCTACTTAAATAGGTAAA；ACTATTTCAGAAACTGGAAAATATCAATGGTGTTACAGATGGCTACTTAAATAGGTAAACTCAGCTAACACTAATCTCATATTTTCCTTTTCTCAAGCTTCTTTTTCTGGGTCTTCAT；TTACTAGCTGTGAGAGGCAAATCTTCACAGACTAATTATGTCACTGGCAATTTTATGTGCTTCTTTTGCTCTTTCCAGCTTATGCACAGTAAGGGCACTGCTCCAGGCTATTCTCCAA；CTTCTTTTGCTCTTTCCAGCTTATGCACAGTAAGGGCACTGCTCCAGGCTATTCTCCAAACAGAAGACATGTTAAAGGTTTATGAAGCCAGGCTCACTGAGGAGGAAACTGTCTGCCT；ACAGAAGACATGTTAAAGGTTTATGAAGCCAGGCTCACTGAGGAGGAAACTGTCTGCCTGGACCTGGATAAAGTGGAAGCTTACCGCTGTGGACTGAAGGTAACTTGAAAGCTTATAA；GGACCTGGATAAAGTGGAAGCTTACCGCTGTGGACTGAAGGTAACTTGAAAGCTTATAACAGTGGCCCAACTTACAGGAACTAATTCAGATCTGAGCTCCCAATTATAAAGCCTCACT；CGCCCAATTTGGTGACTTGTAGTGTAGCATACAATGGGAGAAGGGATTAATTTGCAATCTTTTTTTTTTTCATCTTGCAGAAAATAAAAAATGACTTGAACTTGAAGAAGTCGTTGTT；TTTTTTTTTTTCATCTTGCAGAAAATAAAAAATGACTTGAACTTGAAGAAGTCGTTGTTGGCCACTATGAAGACAGAACTACAGAAAGCCCAGCAGATCCACTCTCAGACTTCACAGC；GGCCACTATGAAGACAGAACTACAGAAAGCCCAGCAGATCCACTCTCAGACTTCACAGCAGTATCCACTTTATGATCTGGACTTGGGCAAGTTCGGTGAAAAAGTCACACAGCTGACA；AGTATCCACTTTATGATCTGGACTTGGGCAAGTTCGGTGAAAAAGTCACACAGCTGACAGACCGCTGGCAAAGGATAGATAAACAGATCGACTTTAGGTATGCCAGCCTCCTCCCGCT；GACCGCTGGCAAAGGATAGATAAACAGATCGACTTTAGGTATGCCAGCCTCCTCCCGCTCCTTCCCCATCTTCTCCCCTTTTGGTTGTTCACAAGATAATGTCACTTGAAGGGAACCA；TGTTACATATTTTAGGAACTAATAAGATAATGATTTTATTGTATCTATTTCCCCCCAGGTTATGGGACCTGGAGAAACAAATCAAGCAATTGAGGAATTATCGTGATAACTATCAGGC；TTATGGGACCTGGAGAAACAAATCAAGCAATTGAGGAATTATCGTGATAACTATCAGGCTTTCTGCAAGTGGCTCTATGATGCTAAACGCCGCCAGGATTCCTTAGAATCCATGAAAT；TTTCTGCAAGTGGCTCTATGATGCTAAACGCCGCCAGGATTCCTTAGAATCCATGAAATTTGGAGATTCCAACACAGTCATGCGGTTTTTGAATGAGCAGAAGGTATAAGCCAACTTT；TTGGAGATTCCAACACAGTCATGCGGTTTTTGAATGAGCAGAAGGTATAAGCCAACTTTTTGTTCCATAGCTGTTTTGAGATTAATTGGGTGTAATTCATGTTTTCCTCTGGTTTTTG；GTAAAAGAGTGAAATCACATTTATTTAAAAATATTTGTATGCATTAACATTGGTAAATATTTCACTTTTTGTATAGAACTTGCACAGTGAAATATCTGGCAAACGAGACAAATCAGAG；TTTCACTTTTTGTATAGAACTTGCACAGTGAAATATCTGGCAAACGAGACAAATCAGAGGAAGTACAAAAAATTGCTGAACTTTGCGCCAATTCAATTAAGGTATGTTGGTTTCATAA；GAAGTACAAAAAATTGCTGAACTTTGCGCCAATTCAATTAAGGTATGTTGGTTTCATAAAGAATGTTGGTATTTCACCAAGATTATTATTAACTGCATGACTTGCTGATTTGTTGTAA；AACTGTAGCTGTTAGTGATGCTTTTTAAGTCTATGAAGGACACTTTTCTTAAACTTCATTATGCTGCAGGATTATGAGCTCCAGCTGGCCTCATACACCTCAGGACTGGAAACTCTGC；TATGCTGCAGGATTATGAGCTCCAGCTGGCCTCATACACCTCAGGACTGGAAACTCTGCTGAACATACCTATCAAGAGGACCATGATTCAGTCCCCTTCTGGGGTGATTCTGCAAGAG；TGAACATACCTATCAAGAGGACCATGATTCAGTCCCCTTCTGGGGTGATTCTGCAAGAGGTATATATGTCATCACATATCTCTTAAAACCTGCCCCTCCTTCTGCTTCTTCCCTTTT；GGTCAAATTACATAGGACTTTTTTTTTAATGCAATATCTTTTTCTTTCTTTCCTTCCTTTTCTCCAAGGCTGCAGATGTTCATGCTCGGTACATTGAACTACTTACAAGATCTGGAGA；TTCTCCAAGGCTGCAGATGTTCATGCTCGGTACATTGAACTACTTACAAGATCTGGAGACTATTACAGGTTCTTAAGTGAGATGCTGAAGAGTTTGGAAGATCTGAAGGTAATTTATA；CTATTACAGGTTCTTAAGTGAGATGCTGAAGAGTTTGGAAGATCTGAAGGTAATTTATACTGTCTTTTCTTGTAGCGTCAAAAAAGAAAATAGAATAGAACCTTATTATTACTTCCAC；TGCTTCTTTCTTGGAATGTGAGGTGTTTTTCTTTTGACATAATCTCTGATTTCATTCCACAGCTGAAAAATACCAAGATCGAAGTTTTGGAAGAGGAGCTCAGACTGGCCCGAGATGC；CAGCTGAAAAATACCAAGATCGAAGTTTTGGAAGAGGAGCTCAGACTGGCCCGAGATGCCAACTCGGAAAACTGTAATAAGAACAAATTCCTGGATCAGAACCTGCAGAAATACCAGG；CAACTCGGAAAACTGTAATAAGAACAAATTCCTGGATCAGAACCTGCAGAAATACCAGGCAGAGTGTTCCCAGTTCAAAGCGAAGCTTGCGAGCCTGGAGGAGCTGAAGAGACAGGCT；CAGAGTGTTCCCAGTTCAAAGCGAAGCTTGCGAGCCTGGAGGAGCTGAAGAGACAGGCTGAGCTGGATGGGAAGTCGGCTAAGCAAAATCTAGACAAGTGCTACGGCCAAATAAAAGA；GAGCTGGATGGGAAGTCGGCTAAGCAAAATCTAGACAAGTGCTACGGCCAAATAAAAGAACTCAATGAGAAGATCACCCGACTGACTTATGAGATTGAAGATGAAAAGAGAAGAAGAA；ACTCAATGAGAAGATCACCCGACTGACTTATGAGATTGAAGATGAAAAGAGAAGAAGAAAATCTGTGGAAGACAGATTTGACCAACAGAAGAATGACTATGACCAACTGCAGAAAGCA；AATCTGTGGAAGACAGATTTGACCAACAGAAGAATGACTATGACCAACTGCAGAAAGCAAGGCAATGTGAAAAGGAGAACCTTGGTTGGCAGAAATTAGAGTCTGAGAAAGCCATCAA；AGGCAATGTGAAAAGGAGAACCTTGGTTGGCAGAAATTAGAGTCTGAGAAAGCCATCAAGGAGAAGGAGTACGAGATTGAAAGGTTGAGGGTTCTACTGCAGGAAGAAGGCACCCGGA；GGAGAAGGAGTACGAGATTGAAAGGTTGAGGGTTCTACTGCAGGAAGAAGGCACCCGGAAGAGAGAATATGAAAATGAGCTGGCAAAGGTAAGAAACCACTATAATGAGGAGATGAGT；AGAGAGAATATGAAAATGAGCTGGCAAAGGTAAGAAACCACTATAATGAGGAGATGAGTAATTTAAGGAACAAGTATGAAACAGAGATTAACATTACGAAGACCACCATCAAGGAGAT；AATTTAAGGAACAAGTATGAAACAGAGATTAACATTACGAAGACCACCATCAAGGAGATATCCATGCAAAAAGAGGATGATTCCAAAAATCTTAGAAACCAGCTTGATAGACTTTCAA；ATCCATGCAAAAAGAGGATGATTCCAAAAATCTTAGAAACCAGCTTGATAGACTTTCAAGGGAAAATCGAGATCTGAAGGATGAAATTGTCAGGCTCAATGACAGCATCTTGCAGGCC；GGGAAAATCGAGATCTGAAGGATGAAATTGTCAGGCTCAATGACAGCATCTTGCAGGCCACTGAGCAGCGAAGGCGAGCTGAAGAAAACGCCCTTCAGCAAAAGGCCTGTGGCTCTGA；ACTGAGCAGCGAAGGCGAGCTGAAGAAAACGCCCTTCAGCAAAAGGCCTGTGGCTCTGAGATAATGCAGAAGAAGCAGCATCTGGAGATAGAACTGAAGCAGGTCATGCAGCAGCGCT；GATAATGCAGAAGAAGCAGCATCTGGAGATAGAACTGAAGCAGGTCATGCAGCAGCGCTCTGAGGACAATGCCCGGCACAAGCAGTCCCTGGAGGAGGCTGCCAAGACCATTCAGGAC；CTGAGGACAATGCCCGGCACAAGCAGTCCCTGGAGGAGGCTGCCAAGACCATTCAGGACAAAAATAAGGAGATCGAGAGACTCAAAGCTGAGTTTCAGGAGGAGGCCAAGCGCCGCTG；AAAAATAAGGAGATCGAGAGACTCAAAGCTGAGTTTCAGGAGGAGGCCAAGCGCCGCTGGGAATATGAAAATGAACTGAGTAAGGTAAGAAACAATTATGATGAGGAGATCATTAGCT；GGAATATGAAAATGAACTGAGTAAGGTAAGAAACAATTATGATGAGGAGATCATTAGCTTAAAAAATCAGTTTGAGACCGAGATCAACATCACCAAGACCACCATCCACCAGCTCACC；TAAAAAATCAGTTTGAGACCGAGATCAACATCACCAAGACCACCATCCACCAGCTCACCATGCAGAAGGAAGAGGATACCAGTGGCTACCGGGCTCAGATAGACAATCTCACCCGAGA；ATGCAGAAGGAAGAGGATACCAGTGGCTACCGGGCTCAGATAGACAATCTCACCCGAGAAAACAGGAGCTTATCTGAAGAAATAAAGAGGCTGAAGAACACTCTAACCCAGACCACAG；AAACAGGAGCTTATCTGAAGAAATAAAGAGGCTGAAGAACACTCTAACCCAGACCACAGAGAATCTCAGGAGGGTGGAAGAAGACATCCAACAGCAAAAGGCCACTGGCTCTGAGGTG；AGAATCTCAGGAGGGTGGAAGAAGACATCCAACAGCAAAAGGCCACTGGCTCTGAGGTGTCTCAGAGGAAACAGCAGCTGGAGGTTGAGCTGAGACAAGTCACTCAGATGCGAACAGA；TCTCAGAGGAAACAGCAGCTGGAGGTTGAGCTGAGACAAGTCACTCAGATGCGAACAGAGGAGAGCGTAAGATATAAGCAATCTCTTGATGATGCTGCCAAAACCATCCAGGATAAAA；GGAGAGCGTAAGATATAAGCAATCTCTTGATGATGCTGCCAAAACCATCCAGGATAAAAACAAGGAGATAGAAAGGTTAAAACAACTGATCGACAAAGAAACAAATGACCGGAAATGC；ACAAGGAGATAGAAAGGTTAAAACAACTGATCGACAAAGAAACAAATGACCGGAAATGCCTGGAAGATGAAAACGCGAGATTACAAAGGGTCCAGTATGACCTGCAGAAAGCAAACAG；CTGGAAGATGAAAACGCGAGATTACAAAGGGTCCAGTATGACCTGCAGAAAGCAAACAGTAGTGCGACGGAGACAATAAACAAACTGAAGGTTCAGGAGCAAGAACTGACACGCCTGA；TAGTGCGACGGAGACAATAAACAAACTGAAGGTTCAGGAGCAAGAACTGACACGCCTGAGGATCGACTATGAAAGGGTTTCCCAGGAGAGGACTGTGAAGGACCAGGATATCACGCGG；GGATCGACTATGAAAGGGTTTCCCAGGAGAGGACTGTGAAGGACCAGGATATCACGCGGTTCCAGAACTCTCTGAAAGAGCTGCAGCTGCAGAAGCAGAAGGTGGAAGAGGAGCTGAA；TTCCAGAACTCTCTGAAAGAGCTGCAGCTGCAGAAGCAGAAGGTGGAAGAGGAGCTGAATCGGCTGAAGAGGACCGCGTCAGAAGACTCCTGCAAGAGGAAGAAGCTGGAGGAAGAGC；TCGGCTGAAGAGGACCGCGTCAGAAGACTCCTGCAAGAGGAAGAAGCTGGAGGAAGAGCTGGAAGGCATGAGGAGGTCGCTGAAGGAGCAAGCCATCAAAATCACCAACCTGACCCAG；TGGAAGGCATGAGGAGGTCGCTGAAGGAGCAAGCCATCAAAATCACCAACCTGACCCAGCAGCTGGAGCAGGCATCCATTGTTAAGAAGAGGAGTGAGGATGACCTCCGGCAGCAGAG；CAGCTGGAGCAGGCATCCATTGTTAAGAAGAGGAGTGAGGATGACCTCCGGCAGCAGAGGGACGTGCTGGATGGCCACCTGAGGGAAAAGCAGAGGACCCAGGAAGAGCTGAGGAGGC；GGACGTGCTGGATGGCCACCTGAGGGAAAAGCAGAGGACCCAGGAAGAGCTGAGGAGGCTCTCTTCTGAGGTCGAGGCCCTGAGGCGGCAGTTACTCCAGGAACAGGAAAGTGTCAAA；TCTCTTCTGAGGTCGAGGCCCTGAGGCGGCAGTTACTCCAGGAACAGGAAAGTGTCAAACAAGCTCACTTGAGGAATGAGCATTTCCAGAAGGCGATAGAAGATAAAAGCAGAAGCTT；CAAGCTCACTTGAGGAATGAGCATTTCCAGAAGGCGATAGAAGATAAAAGCAGAAGCTTAAATGAAAGCAAAATAGAAATTGAGAGGCTGCAGTCTCTCACAGAGAACCTGACCAAGG；AAATGAAAGCAAAATAGAAATTGAGAGGCTGCAGTCTCTCACAGAGAACCTGACCAAGGAGCACTTGATGTTAGAAGAAGAACTGCGGAACCTGAGGCTGGAGTACGATGACCTGAGG；AGCACTTGATGTTAGAAGAAGAACTGCGGAACCTGAGGCTGGAGTACGATGACCTGAGGAGAGGACGAAGCGAAGCGGACAGTGATAAAAATGCAACCATCTTGGAACTAAGGAGCCA；AGAGGACGAAGCGAAGCGGACAGTGATAAAAATGCAACCATCTTGGAACTAAGGAGCCAGCTGCAGATCAGCAACAACCGGACCCTGGAACTGCAGGGGCTGATTAATGATTTACAGA；GCTGCAGATCAGCAACAACCGGACCCTGGAACTGCAGGGGCTGATTAATGATTTACAGAGAGAGAGGGAAAATTTGAGACAGGAAATTGAGAAATTCCAAAAGCAGGCTTTAGAGGTA；GAGAGAGGGAAAATTTGAGACAGGAAATTGAGAAATTCCAAAAGCAGGCTTTAGAGGTATTCACAAATACTTGATCACAGCTTCACTGTTTCTCAAATTATTCATCACATTATTATCT；AGATACACAAAAGAAAGTTAAGTCGTGATAGTAATATGATATGATTCAAAACATTATTTTTTCCCATTTCTTTCTTCTTCAATTCCAGGCATCTAATAGGATTCAGGAATCAAAGAAT；TTTCCCATTTCTTTCTTCTTCAATTCCAGGCATCTAATAGGATTCAGGAATCAAAGAATCAGTGTACTCAGGTGGTACAGGAAAGAGAGAGCCTTCTGGTGAAAATCAAAGTCCTGGA；CAGTGTACTCAGGTGGTACAGGAAAGAGAGAGCCTTCTGGTGAAAATCAAAGTCCTGGAGCAAGACAAGGCAAGGCTGCAGAGGCTGGAGGATGAGCTGAATCGTGCAAAATCAACTC；GCAAGACAAGGCAAGGCTGCAGAGGCTGGAGGATGAGCTGAATCGTGCAAAATCAACTCTAGAGGCAGAAACCAGGGTGAAACAGCGCCTGGAGTGTGAGAAACAGCAAATTCAGAAT；TAGAGGCAGAAACCAGGGTGAAACAGCGCCTGGAGTGTGAGAAACAGCAAATTCAGAATGACCTGAATCAGTGGAAGACTCAATATTCCCGCAAGGAGGAGGCTATTAGGAAGATAGA；GACCTGAATCAGTGGAAGACTCAATATTCCCGCAAGGAGGAGGCTATTAGGAAGATAGAATCGGAAAGAGAAAAGAGTGAGAGAGAGAAGAACAGTCTTAGGAGTGAGATCGAAAGAC；ATCGGAAAGAGAAAAGAGTGAGAGAGAGAAGAACAGTCTTAGGAGTGAGATCGAAAGACTCCAAGCAGAGATCAAGAGAATTGAAGAGAGGTGCAGGCGTAAGCTGGAGGATTCTACC；TCCAAGCAGAGATCAAGAGAATTGAAGAGAGGTGCAGGCGTAAGCTGGAGGATTCTACCAGGGAGACACAGTCACAGTTAGAAACAGAACGCTCCCGATATCAGAGGGAGATTGATAA；AGGGAGACACAGTCACAGTTAGAAACAGAACGCTCCCGATATCAGAGGGAGATTGATAAACTCAGACAGCGCCCATATGGGTCCCATCGAGAGACCCAGACTGAGTGTGAGTGGACCG；ACTCAGACAGCGCCCATATGGGTCCCATCGAGAGACCCAGACTGAGTGTGAGTGGACCGTTGACACCTCCAAGCTGGTGTTTGATGGGCTGAGGAAGAAGGTGACAGCAATGCAGCTC；TTGACACCTCCAAGCTGGTGTTTGATGGGCTGAGGAAGAAGGTGACAGCAATGCAGCTCTATGAGTGTCAGCTGATCGACAAAACAACCTTGGACAAACTATTGAAGGGGAAGAAGTC；TATGAGTGTCAGCTGATCGACAAAACAACCTTGGACAAACTATTGAAGGGGAAGAAGTCAGTGGAAGAAGTTGCTTCTGAAATCCAGCCATTCCTTCGGGGTGCAGGATCTATCGCTG；AGTGGAAGAAGTTGCTTCTGAAATCCAGCCATTCCTTCGGGGTGCAGGATCTATCGCTGGAGCATCTGCTTCTCCTAAGGAAAAATACTCTTTGGTAGAGGCCAAGAGAAAGAAATTA；GAGCATCTGCTTCTCCTAAGGAAAAATACTCTTTGGTAGAGGCCAAGAGAAAGAAATTAATCAGCCCAGAATCCACAGTCATGCTTCTGGAGGCCCAGGCAGCTACAGGTGGTATAAT；ATCAGCCCAGAATCCACAGTCATGCTTCTGGAGGCCCAGGCAGCTACAGGTGGTATAATTGATCCCCATCGGAATGAGAAGCTGACTGTCGACAGTGCCATAGCTCGGGACCTCATTG；TGATCCCCATCGGAATGAGAAGCTGACTGTCGACAGTGCCATAGCTCGGGACCTCATTGACTTCGATGACCGTCAGCAGATATATGCAGCAGAAAAAGCTATCACTGGTTTTGATGAT；ACTTCGATGACCGTCAGCAGATATATGCAGCAGAAAAAGCTATCACTGGTTTTGATGATCCATTTTCAGGCAAGACAGTATCTGTTTCAGAAGCCATCAAGAAAAATTTGATTGATAG；CCATTTTCAGGCAAGACAGTATCTGTTTCAGAAGCCATCAAGAAAAATTTGATTGATAGAGAAACCGGAATGCGCCTGCTGGAAGCCCAGATTGCTTCAGGGGGTGTAGTAGACCCTG；AGAAACCGGAATGCGCCTGCTGGAAGCCCAGATTGCTTCAGGGGGTGTAGTAGACCCTGTGAACAGTGTCTTTTTGCCAAAAGATGTCGCCTTGGCCCGGGGGCTGATTGATAGAGAT；TGAACAGTGTCTTTTTGCCAAAAGATGTCGCCTTGGCCCGGGGGCTGATTGATAGAGATTTGTATCGATCCCTGAATGATCCCCGAGATAGTCAGAAAAACTTTGTGGATCCAGTCAC；TTGTATCGATCCCTGAATGATCCCCGAGATAGTCAGAAAAACTTTGTGGATCCAGTCACCAAAAAGAAGGTCAGTTACGTGCAGCTGAAGGAACGGTGCAGAATCGAACCACATACTG；CAAAAAGAAGGTCAGTTACGTGCAGCTGAAGGAACGGTGCAGAATCGAACCACATACTGGTCTGCTCTTGCTTTCAGTACAGAAGAGAAGCATGTCCTTCCAAGGAATCAGACAACCT；GTCTGCTCTTGCTTTCAGTACAGAAGAGAAGCATGTCCTTCCAAGGAATCAGACAACCTGTGACCGTCACTGAGCTAGTAGATTCTGGTATATTGAGACCGTCCACTGTCAATGAACT；GTGACCGTCACTGAGCTAGTAGATTCTGGTATATTGAGACCGTCCACTGTCAATGAACTGGAATCTGGTCAGATTTCTTATGACGAGGTTGGTGAGAGAATTAAGGACTTCCTCCAGG；GGAATCTGGTCAGATTTCTTATGACGAGGTTGGTGAGAGAATTAAGGACTTCCTCCAGGGTTCAAGCTGCATAGCAGGCATATACAATGAGACCACAAAACAGAAGCTTGGCATTTAT；GTTCAAGCTGCATAGCAGGCATATACAATGAGACCACAAAACAGAAGCTTGGCATTTATGAGGCCATGAAAATTGGCTTAGTCCGACCTGGTACTGCTCTGGAGTTGCTGGAAGCCCA；GAGGCCATGAAAATTGGCTTAGTCCGACCTGGTACTGCTCTGGAGTTGCTGGAAGCCCAAGCAGCTACTGGCTTTATAGTGGATCCTGTTAGCAACTTGAGGTTACCAGTGGAGGAAG；AGCAGCTACTGGCTTTATAGTGGATCCTGTTAGCAACTTGAGGTTACCAGTGGAGGAAGCCTACAAGAGAGGTCTGGTGGGCATTGAGTTCAAAGAGAAGCTCCTGTCTGCAGAACGA；CCTACAAGAGAGGTCTGGTGGGCATTGAGTTCAAAGAGAAGCTCCTGTCTGCAGAACGAGCTGTCACTGGGTATAATGATCCTGAAACAGGAAACATCATCTCTTTGTTCCAAGCCAT；GCTGTCACTGGGTATAATGATCCTGAAACAGGAAACATCATCTCTTTGTTCCAAGCCATGAATAAGGAACTCATCGAAAAGGGCCACGGTATTCGCTTATTAGAAGCACAGATCGCAA；GAATAAGGAACTCATCGAAAAGGGCCACGGTATTCGCTTATTAGAAGCACAGATCGCAACCGGGGGGATCATTGACCCAAAGGAGAGCCATCGTTTACCAGTTGACATAGCATATAAG；CCGGGGGGATCATTGACCCAAAGGAGAGCCATCGTTTACCAGTTGACATAGCATATAAGAGGGGCTATTTCAATGAGGAACTCAGTGAGATTCTCTCAGATCCAAGTGATGATACCAA；AGGGGCTATTTCAATGAGGAACTCAGTGAGATTCTCTCAGATCCAAGTGATGATACCAAAGGATTTTTTGACCCCAACACTGAAGAAAATCTTACCTATCTGCAACTAAAAGAAAGAT；AGGATTTTTTGACCCCAACACTGAAGAAAATCTTACCTATCTGCAACTAAAAGAAAGATGCATTAAGGATGAGGAAACAGGGCTCTGTCTTCTGCCTCTGAAAGAAAAGAAGAAACAG；GCATTAAGGATGAGGAAACAGGGCTCTGTCTTCTGCCTCTGAAAGAAAAGAAGAAACAGGTGCAGACATCACAAAAGAATACCCTCAGGAAGCGTAGAGTGGTCATAGTTGACCCAGA；GTGCAGACATCACAAAAGAATACCCTCAGGAAGCGTAGAGTGGTCATAGTTGACCCAGAAACCAATAAAGAAATGTCTGTTCAGGAGGCCTACAAGAAGGGCCTAATTGATTATGAAA；AACCAATAAAGAAATGTCTGTTCAGGAGGCCTACAAGAAGGGCCTAATTGATTATGAAACCTTCAAAGAACTGTGTGAGCAGGAATGTGAATGGGAAGAAATAACCATCACGGGATCA；CCTTCAAAGAACTGTGTGAGCAGGAATGTGAATGGGAAGAAATAACCATCACGGGATCAGATGGCTCCACCAGGGTGGTCCTGGTAGATAGAAAGACAGGCAGTCAGTATGATATTCA；GATGGCTCCACCAGGGTGGTCCTGGTAGATAGAAAGACAGGCAGTCAGTATGATATTCAAGATGCTATTGACAAGGGCCTTGTTGACAGGAAGTTCTTTGATCAGTACCGATCCGGCA；AGATGCTATTGACAAGGGCCTTGTTGACAGGAAGTTCTTTGATCAGTACCGATCCGGCAGCCTCAGCCTCACTCAATTTGCTGACATGATCTCCTTGAAAAATGGTGTCGGCACCAGC；GCCTCAGCCTCACTCAATTTGCTGACATGATCTCCTTGAAAAATGGTGTCGGCACCAGCAGCAGCATGGGCAGTGGTGTCAGCGATGATGTTTTTAGCAGCTCCCGACATGAATCAGT；AGCAGCATGGGCAGTGGTGTCAGCGATGATGTTTTTAGCAGCTCCCGACATGAATCAGTAAGTAAGATTTCCACCATATCCAGCGTCAGGAATTTAACCATAAGGAGCAGCTCTTTTT；AAGTAAGATTTCCACCATATCCAGCGTCAGGAATTTAACCATAAGGAGCAGCTCTTTTTCAGACACCCTGGAAGAATCGAGCCCCATTGCAGCCATCTTTGACACAGAAAACCTGGAG；CAGACACCCTGGAAGAATCGAGCCCCATTGCAGCCATCTTTGACACAGAAAACCTGGAGAAAATCTCCATTACAGAAGGTATAGAGCGGGGCATCGTTGACAGCATCACGGGTCAGAG；AAAATCTCCATTACAGAAGGTATAGAGCGGGGCATCGTTGACAGCATCACGGGTCAGAGGCTTCTGGAGGCTCAGGCCTGCACAGGTGGCATCATCCACCCAACCACGGGCCAGAAGC；GCTTCTGGAGGCTCAGGCCTGCACAGGTGGCATCATCCACCCAACCACGGGCCAGAAGCTGTCACTTCAGGACGCAGTCTCCCAGGGTGTGATTGACCAAGACATGGCCACCAGGCTG；TGTCACTTCAGGACGCAGTCTCCCAGGGTGTGATTGACCAAGACATGGCCACCAGGCTGAAGCCTGCTCAGAAAGCCTTCATAGGCTTCGAGGGTGTGAAGGGAAAGAAGAAGATGTC；AAGCCTGCTCAGAAAGCCTTCATAGGCTTCGAGGGTGTGAAGGGAAAGAAGAAGATGTCAGCAGCAGAGGCAGTGAAAGAAAAATGGCTCCCGTATGAGGCTGGCCAGCGCTTCCTGG；AGCAGCAGAGGCAGTGAAAGAAAAATGGCTCCCGTATGAGGCTGGCCAGCGCTTCCTGGAGTTCCAGTACCTCACGGGAGGTCTTGTTGACCCGGAAGTGCATGGGAGGATAAGCACC；AGTTCCAGTACCTCACGGGAGGTCTTGTTGACCCGGAAGTGCATGGGAGGATAAGCACCGAAGAAGCCATCCGGAAGGGGTTCATAGATGGCCGCGCCGCACAGAGGCTGCAAGACAC；GAAGAAGCCATCCGGAAGGGGTTCATAGATGGCCGCGCCGCACAGAGGCTGCAAGACACCAGCAGCTATGCCAAAATCCTGACCTGCCCCAAAACCAAATTAAAAATATCCTATAAGG；CAGCAGCTATGCCAAAATCCTGACCTGCCCCAAAACCAAATTAAAAATATCCTATAAGGATGCCATAAATCGCTCCATGGTAGAAGATATCACTGGGCTGCGCCTTCTGGAAGCCGCC；ATGCCATAAATCGCTCCATGGTAGAAGATATCACTGGGCTGCGCCTTCTGGAAGCCGCCTCCGTGTCGTCCAAGGGCTTACCCAGCCCTTACAACATGTCTTCGGCTCCGGGGTCCCG；TCCGTGTCGTCCAAGGGCTTACCCAGCCCTTACAACATGTCTTCGGCTCCGGGGTCCCGCTCCGGCTCCCGCTCGGGATCTCGCTCCGGATCTCGCTCCGGGTCCCGCAGTGGGTCCC；CTCCGGCTCCCGCTCGGGATCTCGCTCCGGATCTCGCTCCGGGTCCCGCAGTGGGTCCCGGAGAGGAAGCTTTGACGCCACAGGGAATTCTTCCTACTCTTATTCCTACTCATTTAGC；GGAGAGGAAGCTTTGACGCCACAGGGAATTCTTCCTACTCTTATTCCTACTCATTTAGCAGTAGTTCTATTGGGCACTAGTAGTCAGTTGGGAGTGGTTGCTATACCTTGACTTCATT；AGTAGTTCTATTGGGCACTAGTAGTCAGTTGGGAGTGGTTGCTATACCTTGACTTCATTTATATGAATTTCCACTTTATTAAATAATAGAAAAGAAAATCCCGGTGCTTGCAGTAGAG；
所述探针组12由如下核酸分子组成：
CTGCCAGCTTTTTATCTTTCTCTCGACCACTTAAAACTTCAGACTTCCTGTCCTGCTGGTATCATGGAGAAAGTCCAATACCTCACTCGCTCAGCTATAAGAAGAGCCTCAACCATTG；TATCATGGAGAAAGTCCAATACCTCACTCGCTCAGCTATAAGAAGAGCCTCAACCATTGAAATGCCTCAACAAGCACGTCAAAAGCTACAGAATCTATTTATCAATTTCTGTCTCATC；AAATGCCTCAACAAGCACGTCAAAAGCTACAGAATCTATTTATCAATTTCTGTCTCATCTTAATATGTCTCTTGCTGATCTGTATCATCGTGATGCTTCTCTGAAGTTCTGCTACAAC；TTAATATGTCTCTTGCTGATCTGTATCATCGTGATGCTTCTCTGAAGTTCTGCTACAACCTCTAGATCTGCAGCTTGCCACATCAGCTTAAAATCTGTCATCCCATGCAGACAGGAAA。
3.根据权利要求2所述的试剂盒，其特征在于：
每条所述核酸分子的5’端和3’端分别连有接头序列。
4.权利要求2中所述的成套RNA探针。
5.一种用于检测或辅助检测与遗传性心肌疾病相关基因变异的成套试剂，其包括权利要求2中所述的成套RNA探针。
6.根据权利要求5所述的成套试剂，其特征在于：
每条核酸分子在成套试剂中的终浓度均为(1-10)×10-6pmol/ul。
7.权利要求1-3中任一所述的试剂盒或权利要求4所述的成套RNA探针或权利要求5或6所述的成套试剂在检测或辅助检测与遗传性心肌疾病相关基因变异中的应用。
8.权利要求1-3中任一所述的试剂盒或权利要求4所述的成套RNA探针或权利要求5或6所述的成套试剂在制备检测或辅助检测与遗传性心肌疾病相关基因变异的产品中的应用。
9.一种检测或辅助检测与遗传性心肌疾病相关基因变异的方法，包括如下步骤：
(1)采用Tn5转座酶方法构建目的基因组DNA文库；
(2)利用液相杂交法将权利要求2中所述的成套RNA探针与所述DNA文库杂交，得到杂交产物；
(3)对所述杂交产物进行二代测序，根据测序结果分析目的基因组DNA的变异情况。
10.权利要求1-3中任一所述的试剂盒或权利要求4所述的成套RNA探针或权利要求5或6所述的成套试剂或权利要求7或8所述的应用或权利要求9所述的方法，其特征在于：所述遗传性心肌疾病为致心律失常性右室心肌病和/或扩张型心肌病；
所述与遗传性心肌疾病相关基因为LMNA基因、RYR2基因、CTNNA3基因、PKP2基因、TGFB3基因、JUP基因、DSC2基因、DSG2基因、DES基因、TMEM43基因、DSP基因和/或PLN基因。
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WO2019131470A1 (en) * 2017-12-25 2019-07-04 Toyota Jidosha Kabushiki Kaisha A primer for next generation sequencer and a method for producing the same, a dna library obtained through the use of a primer for next generation sequencer and a method for producing the same, and a dna analyzing method using a dna library
WO2019153241A1 (zh) * 2018-02-09 2019-08-15 深圳华大生命科学研究院 与主要不良心血管事件相关的单核苷酸多态性位点及其应用
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WO2019131470A1 (en) * 2017-12-25 2019-07-04 Toyota Jidosha Kabushiki Kaisha A primer for next generation sequencer and a method for producing the same, a dna library obtained through the use of a primer for next generation sequencer and a method for producing the same, and a dna analyzing method using a dna library
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WO2019153241A1 (zh) * 2018-02-09 2019-08-15 深圳华大生命科学研究院 与主要不良心血管事件相关的单核苷酸多态性位点及其应用
CN111670256A (zh) * 2018-02-09 2020-09-15 深圳华大生命科学研究院 与主要不良心血管事件相关的单核苷酸多态性位点及其应用
CN111670256B (zh) * 2018-02-09 2023-10-27 深圳华大生命科学研究院 与主要不良心血管事件相关的单核苷酸多态性位点及其应用
CN112251501A (zh) * 2020-10-28 2021-01-22 深圳人体密码基因科技有限公司 一种内参基因集合及其筛选方法、通用引物组、试剂盒、反应体系及应用
CN113652422A (zh) * 2021-08-08 2021-11-16 华中科技大学同济医学院附属协和医院 Jup基因突变体及其应用
CN113684273A (zh) * 2021-09-08 2021-11-23 百世诺(北京)医学检验实验室有限公司 基于突变的dsg2基因的扩张型心肌病检测试剂盒

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