CN107510842B - 一种具有光热效果的复合光热剂的制备方法 - Google Patents
一种具有光热效果的复合光热剂的制备方法 Download PDFInfo
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- CN107510842B CN107510842B CN201710694641.5A CN201710694641A CN107510842B CN 107510842 B CN107510842 B CN 107510842B CN 201710694641 A CN201710694641 A CN 201710694641A CN 107510842 B CN107510842 B CN 107510842B
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- 239000002131 composite material Substances 0.000 title claims abstract description 23
- 230000000694 effects Effects 0.000 title claims abstract description 18
- 239000012221 photothermal agent Substances 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 62
- 238000006243 chemical reaction Methods 0.000 claims abstract description 52
- 239000008367 deionised water Substances 0.000 claims abstract description 46
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 46
- 239000000243 solution Substances 0.000 claims abstract description 34
- 239000006185 dispersion Substances 0.000 claims abstract description 23
- 239000004005 microsphere Substances 0.000 claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 15
- CTENFNNZBMHDDG-UHFFFAOYSA-N Dopamine hydrochloride Chemical compound Cl.NCCC1=CC=C(O)C(O)=C1 CTENFNNZBMHDDG-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960001149 dopamine hydrochloride Drugs 0.000 claims abstract description 13
- 238000000502 dialysis Methods 0.000 claims abstract description 12
- 239000002105 nanoparticle Substances 0.000 claims abstract description 11
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000011114 ammonium hydroxide Nutrition 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 8
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims abstract description 7
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims abstract description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229960003638 dopamine Drugs 0.000 claims abstract description 3
- 238000001914 filtration Methods 0.000 claims abstract description 3
- 239000012046 mixed solvent Substances 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 239000000178 monomer Substances 0.000 claims abstract description 3
- 230000001590 oxidative effect Effects 0.000 claims abstract description 3
- 239000002245 particle Substances 0.000 claims abstract description 3
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 3
- 239000012266 salt solution Substances 0.000 claims abstract description 3
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 3
- 239000011593 sulfur Substances 0.000 claims abstract description 3
- 238000003760 magnetic stirring Methods 0.000 claims description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 2
- 229910000366 copper(II) sulfate Inorganic materials 0.000 claims description 2
- 229960003280 cupric chloride Drugs 0.000 claims description 2
- 239000012299 nitrogen atmosphere Substances 0.000 claims description 2
- 229910052979 sodium sulfide Inorganic materials 0.000 claims description 2
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 claims description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 8
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 238000001308 synthesis method Methods 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 description 22
- 229920001690 polydopamine Polymers 0.000 description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 238000011282 treatment Methods 0.000 description 9
- 238000005303 weighing Methods 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 7
- 239000012295 chemical reaction liquid Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- OMZSGWSJDCOLKM-UHFFFAOYSA-N copper(II) sulfide Chemical compound [S-2].[Cu+2] OMZSGWSJDCOLKM-UHFFFAOYSA-N 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 238000005057 refrigeration Methods 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 4
- MPTQRFCYZCXJFQ-UHFFFAOYSA-L copper(II) chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Cu+2] MPTQRFCYZCXJFQ-UHFFFAOYSA-L 0.000 description 4
- ZGHLCBJZQLNUAZ-UHFFFAOYSA-N sodium sulfide nonahydrate Chemical compound O.O.O.O.O.O.O.O.O.[Na+].[Na+].[S-2] ZGHLCBJZQLNUAZ-UHFFFAOYSA-N 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000007626 photothermal therapy Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000002371 ultraviolet--visible spectrum Methods 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- PODWXQQNRWNDGD-UHFFFAOYSA-L sodium thiosulfate pentahydrate Chemical compound O.O.O.O.O.[Na+].[Na+].[O-]S([S-])(=O)=O PODWXQQNRWNDGD-UHFFFAOYSA-L 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710694641.5A CN107510842B (zh) | 2017-08-15 | 2017-08-15 | 一种具有光热效果的复合光热剂的制备方法 |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710694641.5A CN107510842B (zh) | 2017-08-15 | 2017-08-15 | 一种具有光热效果的复合光热剂的制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107510842A CN107510842A (zh) | 2017-12-26 |
| CN107510842B true CN107510842B (zh) | 2020-04-24 |
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| CN201710694641.5A Active CN107510842B (zh) | 2017-08-15 | 2017-08-15 | 一种具有光热效果的复合光热剂的制备方法 |
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| CN (1) | CN107510842B (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478811B (zh) * | 2018-03-31 | 2021-11-30 | 湖北大学 | 一种高性能的光热诊疗一体化纳米颗粒及其制备方法 |
| CN109603910B (zh) * | 2018-12-07 | 2021-09-07 | 山东大学 | 一种光热增强降解化学战剂模拟物的纳米核壳复合物及其复合纤维膜的制备方法与应用 |
| CN110433316B (zh) * | 2019-08-28 | 2021-05-25 | 中国科学院上海硅酸盐研究所 | 一种光热/离子协同抗菌水凝胶及其制备方法和应用 |
| CN111074539B (zh) * | 2019-12-27 | 2022-04-12 | 武汉纺织大学 | 一种具有核壳结构光热转换材料的织物及其制备方法 |
| CN111773200B (zh) * | 2020-07-14 | 2021-04-13 | 中南大学 | 一种酸性环境中可降解的表面涂层及其制备方法与应用 |
| CN113499483B (zh) * | 2021-06-28 | 2022-05-24 | 福州大学 | 一种纳米硫化铜涂层修饰的记忆合金食管支架及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920624A (zh) * | 2016-05-27 | 2016-09-07 | 湖北大学 | 一种具有核壳结构的mri及ptt诊疗一体化功能微球及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10835605B2 (en) * | 2015-10-01 | 2020-11-17 | University Of South Carolina | Preparations of poly(lactic-co-glycolic acid)/polydopamine core/shell hybrid nanoparticle for photothermal applications |
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- 2017-08-15 CN CN201710694641.5A patent/CN107510842B/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920624A (zh) * | 2016-05-27 | 2016-09-07 | 湖北大学 | 一种具有核壳结构的mri及ptt诊疗一体化功能微球及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| "Polypyrrole-modified CuS nanoprisms for efficient near-infrared photothermal therapy";Ruiyang Zhao等;《RSC Advances》;20170206(第7期);第10143-10149页 * |
| "用于癌症可视化光热治疗的聚吡咯纳米粒子";梁晓龙等;《第十九届中国科协年会——分8高性能高分子材料——从基础到应用学术研讨会论文集》;20170624;第1-15页 * |
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| CN107510842A (zh) | 2017-12-26 |
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Inventor after: Xu Zushun Inventor after: Xiong Yuxuan Inventor after: Li Quantao Inventor after: Liu Pei Inventor after: Yang Zhe Inventor after: Yu Yiming Inventor after: Liu Mengyi Inventor before: Xu Zushun Inventor before: Xiong Yuxuan Inventor before: Liu Pei Inventor before: Yang Zhe Inventor before: Yu Yiming Inventor before: Liu Mengyi |
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Application publication date: 20171226 Assignee: Yunnan Benyi Biotechnology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023530000010 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230403 |
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Application publication date: 20171226 Assignee: Kunming Junxiang Pharmaceutical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023980034488 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230406 Application publication date: 20171226 Assignee: Kunming Daren Medical Equipment Co.,Ltd. Assignor: Hubei University Contract record no.: X2023980034461 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230404 |
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Application publication date: 20171226 Assignee: Hubei yapunodi Technology Development Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000144 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230606 Application publication date: 20171226 Assignee: Hubei Yunyihui Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000143 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230606 |
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Application publication date: 20171226 Assignee: Hubei Yueming Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000151 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230608 Application publication date: 20171226 Assignee: BORUNCHENG (WUHAN) PHARMACEUTICAL CO.,LTD. Assignor: Hubei University Contract record no.: X2023420000155 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230608 Application publication date: 20171226 Assignee: Wuhan Yihui Medical Technology Service Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000158 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230609 Application publication date: 20171226 Assignee: Wuhan Ruixin Zetai Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000156 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230608 Application publication date: 20171226 Assignee: Wuhan Dorman Health Technology Partnership (L.P.) Assignor: Hubei University Contract record no.: X2023420000149 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230607 Application publication date: 20171226 Assignee: Wuhan Zhencai Intelligent Manufacturing Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000150 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230608 Application publication date: 20171226 Assignee: Wuhan Zero Action Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000148 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230607 Application publication date: 20171226 Assignee: Wuhan golden Jirui Medical Technology Development Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000152 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230608 Application publication date: 20171226 Assignee: Wuhan Weier Laibo Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000153 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230608 Application publication date: 20171226 Assignee: Wuhan Hengtai Bainian Trading Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000157 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230609 Application publication date: 20171226 Assignee: Hubei Wanhai Saikang Life Science Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000154 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230608 |
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Application publication date: 20171226 Assignee: Wuhan Dorman Health Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000161 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230612 Application publication date: 20171226 Assignee: Wuhan Zhencai Zhizao Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000162 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230612 Application publication date: 20171226 Assignee: Hubei Shengrui Medical Equipment Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000163 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230612 Application publication date: 20171226 Assignee: Wuhan Kaikang Technology Development Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000164 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230612 Application publication date: 20171226 Assignee: Wuhan Warmth Medical Services Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000178 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230615 Application publication date: 20171226 Assignee: WUHAN JUNAN YOULIAN MEDICAL TECHNOLOGY Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000165 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230612 Application publication date: 20171226 Assignee: Hubei Zeshunzhi Science and Trade Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000174 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230614 Application publication date: 20171226 Assignee: Hubei Zheshunkai Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000177 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230615 Application publication date: 20171226 Assignee: Wuhan Jingdong Medical Technology Partnership (L.P.) Assignor: Hubei University Contract record no.: X2023420000159 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230612 Application publication date: 20171226 Assignee: Wuhan Lingyi Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000160 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230612 |
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Application publication date: 20171226 Assignee: Wuhan Youyimo Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000179 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230616 Application publication date: 20171226 Assignee: Hanli Kechuang (Wuhan) Medical Service Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000182 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230616 Application publication date: 20171226 Assignee: Wuhan Shuidi 1872 Medical Technology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000180 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230616 Application publication date: 20171226 Assignee: Wuhan Yiran Biotechnology Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000181 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230616 Application publication date: 20171226 Assignee: Wuhan Youyimo Hankou Medical Management Co.,Ltd. Assignor: Hubei University Contract record no.: X2023420000184 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230616 |
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Application publication date: 20171226 Assignee: Weimi Medical (Yunnan) Co.,Ltd. Assignor: Hubei University Contract record no.: X2023980040027 Denomination of invention: Preparation method of a composite photothermal agent with photothermal effect Granted publication date: 20200424 License type: Common License Record date: 20230822 |
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