CN107496526B - One kind having anti-inflammatory effect, reduces irritating pharmaceutical composition - Google Patents
One kind having anti-inflammatory effect, reduces irritating pharmaceutical composition Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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Abstract
The invention belongs to traditional Chinese medicine or cosmetic technical fields, and in particular to one kind has anti-inflammatory effect, reduces irritating pharmaceutical composition, which includes: Chinese herbaceous peony, Swertia patens, long gleditsia sinensis, cacumen biotae, Cortex Magnoliae Officinalis；It is prepared into washing lotion, for alopecia with inflammation, itch, the products such as including shampoo, experimental study shows that product of the present invention has anti-inflammatory, reduction scratchiness, reduction irritation effect well.
Description
Technical field
The invention belongs to traditional Chinese medicine or change daily use chemicals technical field, and in particular to one kind has anti-inflammatory effect, reduces irritation
Pharmaceutical composition.
Background technique
Alopecia (alopecia) is clinical common trichonosis, though not belonging to serious disease, is produced to spirit, the psychology of people
Raw large effect.With the improvement of living standards, requirement of the people to cosmetology is increasingly urgent to, modern medicine and motherland are passed
Medicine of uniting also increasingly payes attention to the research to alopecia.Alopecia can be divided into alopecia areata, alopecia seborrheica, alopecia due to chemotherapy, senile de-
The multiple types such as hair, chronic telogen effluvim, post disease alopecia.Wherein alopecia areata and alopecia seborrheica disease incidence highest, and it is obstinate difficult
It controls, is two clinically common class alopecias.
Alopecia seborrheica is more common in male person between twenty and fifty, often shows as from the beginning of forehead and two sides baldness, gradually symmetrically to the crown
Portion extends, and the very thin rareness of hair, conscious phlegm is itched, and vigorous with scalp sebum secretion.Main pathological manifestations are the hair of resting stage
Capsule quantity increases, and the hair follicle quantity of growth terminal phase is reduced, and hair follicle is obviously miniaturized, and growth period shortens, and course of disease latter stage can have inflammation
Disease and fibrosis.Corium almost disappears with subcutaneous tissue capillary clump, and platelet aggregation, which increases, blood is viscous increases.
Therefore, it will lead to inflammation generation when alopecia, while with scratchiness, therefore, research and develop a kind of with anti-inflammatory, drop
The pharmaceutical composition of low irritant is used for alopecia, hair tonic, is of great significance.
Summary of the invention
For these reasons, applicant has found a kind of new pharmaceutical composition after study, with Chinese herbaceous peony in the pharmaceutical composition
Medicine, Swertia patens, long gleditsia sinensis, cacumen biotae, Cortex Magnoliae Officinalis are raw material, are prepared into washing lotion, for alopecia with inflammation, itch, including hair washing
The products such as liquid, experimental study show that product of the present invention has anti-inflammatory, reduction scratchiness, reduction irritation effect well.
In prescription of the present invention: Chinese herbaceous peony has the effects that calmness, hypnosis, antibacterial, anti-inflammatory, anti-oxidant, blood pressure lowering, is Fang Zhongjun
Medicine；Swertia patens have clearing heat and detoxicating, clear liver and gallbladder and other effects, and long gleditsia sinensis has wind-dispelling phlegm, removes wet poison, disinsection efficiency, and the two is closed
Alleviated scalp inflammation to be reached with monarch drug in a prescription Chinese herbaceous peony for ministerial drug in side, is assisted, inhibit scalp chlosma activity, enhancing scalp blood
Liquid microcirculation；Cacumen biotae has the effect of cooling blood and hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair, and there is Cortex Magnoliae Officinalis gas consumption product, eliminating dampness to remove
Completely, the effect of relieving asthma, Papillary is adjutant；Chinese herbaceous peony compatibility Swertia patens, long gleditsia sinensis, are aided with cacumen biotae magnolia obovata, play altogether
It is antipruritic, anti-inflammatory and other effects, alopecia is further prevented, hair tonic is promoted.
What the present invention was achieved through the following technical solutions.
One kind having anti-inflammatory effect, reduces irritating pharmaceutical composition, and pharmaceutical composition includes: Chinese herbaceous peony, Swertia patens, length
Gleditsia sinensis, cacumen biotae, Cortex Magnoliae Officinalis.
Described one kind has anti-inflammatory effect, reduces irritating pharmaceutical composition, and wherein pharmaceutical composition includes: Chinese herbaceous peony
Extract, Herba Swertiae bimaculatae extract, long Fructus Gleditsiae Abnormalis extract, Cacumen Platycladi extract, Magnolia cortex P.E.
Described one kind has anti-inflammatory effect, reduces irritating pharmaceutical composition, and wherein pharmaceutical composition includes: Chinese herbaceous peony
Extract 0.05-0.2 parts by weight, Herba Swertiae bimaculatae extract 0.20-0.40 parts by weight, long Fructus Gleditsiae Abnormalis extract 0.1-0.25 parts by weight,
Cacumen Platycladi extract 0.15-0.30 parts by weight, Magnolia cortex P.E 0.1-0.25 parts by weight.
Described one kind has anti-inflammatory effect, reduces irritating pharmaceutical composition, and wherein pharmaceutical composition includes: Chinese herbaceous peony
0.15 parts by weight of extract, 0.30 parts by weight of Herba Swertiae bimaculatae extract, 0.15 parts by weight of long Fructus Gleditsiae Abnormalis extract, Cacumen Platycladi extract
0.25 parts by weight, 0.20 parts by weight of Magnolia cortex P.E.
Described one kind has anti-inflammatory, the irritating pharmaceutical composition of reduction, and feature pharmaceutical composition is raw material preparation
At washing lotion or shampoo.
Described one kind has anti-inflammatory, the irritating pharmaceutical composition of reduction, and wherein the raw material of washing lotion or shampoo includes:
Peony extract 0.05-0.2 parts by weight, Herba Swertiae bimaculatae extract 0.20-0.40 parts by weight, long Fructus Gleditsiae Abnormalis extract 0.1-0.25 weight
Part, Cacumen Platycladi extract 0.15-0.30 parts by weight, Magnolia cortex P.E 0.1-0.25 parts by weight, polyalcohol 1.5-2.3 parts by weight,
Deionized water 2.1-3.8 parts by weight, solubilizer 0.1-0.3 parts by weight.
Described one kind has anti-inflammatory, the irritating pharmaceutical composition of reduction, and wherein the raw material of washing lotion or shampoo includes:
0.15 parts by weight of peony extract, 0.30 parts by weight of Herba Swertiae bimaculatae extract, 0.15 parts by weight of long Fructus Gleditsiae Abnormalis extract, cacumen biotae are extracted
0.25 parts by weight of object, 0.20 parts by weight of Magnolia cortex P.E, polyalcohol 1.5-2.3 parts by weight, deionized water 2.1-3.8 parts by weight,
Solubilizer 0.1-0.3 parts by weight.
Described one kind has anti-inflammatory, the irritating pharmaceutical composition of reduction, and wherein polyalcohol is 1,3-BDO, 1,3-
One or more of propylene glycol, glycerol.
Described one kind has anti-inflammatory, the irritating pharmaceutical composition of reduction, and wherein solubilizer is PEG-20 polysorbate
It is ester, Cremophor RH40, one or more of in PEG-60 rilanit special.
The other extract sources of the present invention are shown in Table 1.
The extract source of the present invention of table 1
| Group | Manufacturer | Date of manufacture |
| Peony extract | Guangzhou He Ji Biotechnology Co., Ltd | 2016.04.09 |
| Herba Swertiae bimaculatae extract | Hunan Jia Mu Biotechnology Co., Ltd | 2017.03.07 |
| Long Fructus Gleditsiae Abnormalis extract | Guangzhou He Ji Biotechnology Co., Ltd | 2016.05.21 |
| Cacumen Platycladi extract | Guangzhou He Ji Biotechnology Co., Ltd | 2016.08.24 |
| Magnolia cortex P.E | Hunan Jia Mu Biotechnology Co., Ltd | 2017.03.11 |
Specific embodiment
Below the technical scheme of the invention is illustrated by a specific example, but the scope of the present invention is not limited thereto.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention
Range should not be construed as being limited to the specific forms stated in the embodiments, and protection scope of the present invention is also and in art technology
Personnel conceive according to the present invention it is conceivable that equivalent technologies mean.Although embodiment of the invention below is retouched
It states, but the invention is not limited to above-mentioned specific embodiments and applications field, following specific embodiments is only to show
It is meaning property, guiding, rather than it is restrictive.Those skilled in the art under the enlightenment of this specification and are not taking off
In the case where the range protected from the claims in the present invention, a variety of forms can also be made, these belong to the present invention
The column of protection.
The following tests of the present invention are on the basis of multiple creative test, with the claimed technical solution of the present invention
Based on, the conclusive test of the research staff of summary.
Test 1 prescription Dismemberment study
1 group: peony extract 0.15g, Herba Swertiae bimaculatae extract 0.30g, long Fructus Gleditsiae Abnormalis extract 0.15g, cacumen biotae is tested to mention
Take object 0.25g, Magnolia cortex P.E 0.20g；
2 groups: peony extract 0.15g, long Fructus Gleditsiae Abnormalis extract 0.15g, Cacumen Platycladi extract 0.25g, Cortex Magnoliae Officinalis is tested to extract
Object 0.20g；
3 groups: peony extract 0.15g, Herba Swertiae bimaculatae extract 0.30g, Cacumen Platycladi extract 0.25g, Cortex Magnoliae Officinalis is tested to extract
Object 0.20g；
4 groups: peony extract 0.15g, Herba Swertiae bimaculatae extract 0.30g, long Fructus Gleditsiae Abnormalis extract 0.15g, Cortex Magnoliae Officinalis is tested to extract
Object 0.20g；
5 groups: peony extract 0.15g, Herba Swertiae bimaculatae extract 0.30g, long Fructus Gleditsiae Abnormalis extract 0.15g, cacumen biotae is tested to mention
Take object 0.25g；
Test method: taking test group extract respectively, and it is poly- that 1,3-BDO 1.9g, deionized water 3.0g, PEG-20 is added
Sorbitol ester 0.2g, homogeneous 4 minutes after mixing, obtains test product.Selection male KM kind mouse, SPF grades, weight 18-
22g, male and female dual-purpose are tested groups of animals from the first day and are all made of after 10%NaS solution lose hair or feathers in back, it is random that animal is pressed weight
Grouping, is divided into each test group, control group, every group 12, each test group take be applied to outside 1ml alternate products hair removal section (control group to
Give the deionized water of equal capacity), 2 times a day, anti-inflammatory experiment is carried out after continuous use 14 days.It is uniformly applied after last dose 60min
Scorching in auris dextra cause with dimethylbenzene 0.02ml, after 15min, cervical dislocation is put to death, and is laid respectively at the same position of bilateral ear with punch
One circle auricle, is weighed with electronic balance.It calculates swelling (swelling=auris dextra slice weight-left auricle weight).
Test result: 2 are shown in Table.
The influence of 2 paraxylene induced mice auricle edema of table
Note: P < 0.05 * * P < 0.01 compared with the control group, *.
Conclusion (of pressure testing): anti-inflammation test shows that (test 2 and test 3) is compared with the control group without conspicuousness after removing ministerial drug
Difference after removing adjuvant, has significant difference with control group, but, present composition test group has pole compared with the control group
Significant difference (P < 0.01) further illustrates, the superposition of the not simple flavour of a drug of the present composition that scientific is significant
Prescription.
Test 2
Mouse peritoneal permeability influences
1 group: peony extract 0.15g, Herba Swertiae bimaculatae extract 0.30g, long Fructus Gleditsiae Abnormalis extract 0.15g, cacumen biotae is tested to mention
Take object 0.25g, Magnolia cortex P.E 0.20g；
Test method: taking test group extract respectively, and it is poly- that 1,3-BDO 1.9g, deionized water 3.0g, PEG-20 is added
Sorbitol ester 0.2g, homogeneous 4 minutes after mixing, obtains test product.Selection male KM kind mouse, SPF grades, weight 18-
22g, male and female dual-purpose are tested groups of animals from the first day and are all made of after 10%NaS solution lose hair or feathers in back, it is random that animal is pressed weight
Grouping, every group 12, each test group, which takes, is applied to hair removal section (control group gives the deionized water for waiting capacity) outside 1ml alternate products,
2 times a day, anti-inflammatory experiment is carried out after continuous use 14 days.0.25% Evans blue of tail vein injection after last dose 60min, together
When be injected intraperitoneally glacial acetic acid, after 15min, cervical dislocation is put to death, and injects 6ml normal saline flushing abdominal cavity, abdominal cavity eluate 2000r/
Min is centrifuged 10min, and supernatant is taken to measure light absorption value at 590nm.
Test result: 3 are shown in Table.
Table 3 influences mouse peritoneal permeability
Conclusion (of pressure testing): the anti-inflammation test of test 1 and test 2 shows that pharmaceutical composition of the present invention has very local inflammation
Good inhibiting effect, and it is unobvious to systemic inflammatorome effect, it absolutely proves, pharmaceutical composition of the present invention is anti-inflammatory for scalp, tool
There is good effect.
Test 3
Dextran causes the test of mouse itch
1 group: peony extract 0.15g, Herba Swertiae bimaculatae extract 0.30g, long Fructus Gleditsiae Abnormalis extract 0.15g, cacumen biotae is tested to mention
Take object 0.25g, Magnolia cortex P.E 0.20g；
Test method: taking test group extract respectively, and it is poly- that 1,3-BDO 1.9g, deionized water 3.0g, PEG-20 is added
Sorbitol ester 0.2g, homogeneous 4 minutes after mixing, obtains test product.Selection male KM kind mouse, SPF grades, weight 18-
22g, male and female dual-purpose are tested groups of animals from the first day and are all made of after 10%NaS solution lose hair or feathers in back, it is random that animal is pressed weight
Grouping, every group 12, each test group, which takes, is applied to hair removal section (control group gives the deionized water for waiting capacity) outside 1ml alternate products,
2 times a day, 2 times a day, 10 days laggard whereabouts of continuous use are itched experiment.After last medication 30min, mouse tail vein injection
0.025% dextran scratches head with mouse fore paw, and rear solid end scratches trunk, and each position of the whole body that bites is as itch indication, note
Record the incubation period of the number of mouse itch breaking-out and itch breaking-out in 30min.
Test result is shown in Table 4.
Influence of the table 4 to itch caused by dextran
Note: P < 0.05 * compared with the control group.
Conclusion (of pressure testing): it is above-mentioned experiments have shown that, pharmaceutical composition of the present invention has the function of good antipruritic, has certain
The irritating performance of reduction.
Prepare embodiment
Embodiment 1
Peony extract 15g, Herba Swertiae bimaculatae extract 30g, long Fructus Gleditsiae Abnormalis extract 15g, Cacumen Platycladi extract 25g, Cortex Magnoliae Officinalis mention
Take object 20g, 1,3-BDO 190g, deionized water 300g, PEG-20 polysorbate20 g.
Extract is taken respectively, 1,3-BDO, deionized water, PEG-20 polysorbate is added, homogeneous 4 divides after mixing
Clock obtains product.
Embodiment 2
Peony extract 5g, Herba Swertiae bimaculatae extract 20g, long Fructus Gleditsiae Abnormalis extract 10g, Cacumen Platycladi extract 15g, Cortex Magnoliae Officinalis are extracted
Object 10g, 1,3-PD 150g, deionized water 210g, Cremophor RH40 20g.
Extract is taken respectively, 1,3-PD, deionized water, Cremophor RH40 is added, homogeneous 4 divides after mixing
Clock obtains product.
Embodiment 3
Peony extract 20g, Herba Swertiae bimaculatae extract 40g, long Fructus Gleditsiae Abnormalis extract 25g, Cacumen Platycladi extract 30g, Cortex Magnoliae Officinalis mention
Take object 25g, glycerol 230g, deionized water 380g, PEG-60 rilanit special 30g.
Extract is taken respectively, 1,3-PD, deionized water, Cremophor RH40 is added, homogeneous 4 divides after mixing
Clock obtains product.
5 embodiment 4- embodiment of table, 6 raw material proportioning
Preparation method: taking 67% deionized water of recipe quantity weight, is heated to 80-85 DEG C, keeps 30min.It sequentially adds
EDETATE SODIUM, AES (70%), CAB-35, guar gum stir 5min, then homogeneous 15min.It, will be preparatory after temperature drops to room temperature
The Lavender that mixes, D-pantothenyl aleohol, 1,2- pentanediol, in 1,3-BG addition system, stirs 10min at Rosemary Oil.According to
Raw material in secondary addition embodiment stirs 10min.Citric acid and sodium chloride is added.PH=5-7 is adjusted, deionized water is eventually adding
To recipe quantity 100%.It is filling after the filtering of 1200 mesh, obtain shampoo.
It is including but not limited to above-mentioned to prepare embodiment.
Claims (4)
1. one kind has anti-inflammatory effect, reduces the irritating externally-applied medicinal composition of itch, it is characterised in that pharmaceutical composition are as follows:
0.15 parts by weight of peony extract, 0.30 parts by weight of Herba Swertiae bimaculatae extract, 0.15 parts by weight of long Fructus Gleditsiae Abnormalis extract, cacumen biotae are extracted
0.25 parts by weight of object, 0.20 parts by weight of Magnolia cortex P.E.
2. it is according to claim 1 a kind of with anti-inflammatory effect, the reduction irritating externally-applied medicinal composition of itch, it is special
Sign is that the pharmaceutical composition is prepared into washing lotion or shampoo；
The wherein raw material of washing lotion or shampoo are as follows: 0.15 parts by weight of peony extract, 0.30 parts by weight of Herba Swertiae bimaculatae extract, long soap
0.15 parts by weight of horn extraction, 0.25 parts by weight of Cacumen Platycladi extract, 0.20 parts by weight of Magnolia cortex P.E, 1.9 weight of polyalcohol
Part, 3 parts by weight of deionized water, 0.2 parts by weight of solubilizer.
3. it is according to claim 2 a kind of with anti-inflammatory effect, the reduction irritating externally-applied medicinal composition of itch, wherein
Polyalcohol is one or more of 1,3-BDO, 1,3-PD, glycerol.
4. it is according to claim 2 a kind of with anti-inflammatory effect, the reduction irritating externally-applied medicinal composition of itch, wherein
Solubilizer is PEG-20 polysorbate, Cremophor RH40, one or more of in PEG-60 rilanit special.
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| CN103536486A (en) * | 2013-10-18 | 2014-01-29 | 桂林雪芙莲日化有限公司 | Anti-hair loss shampoo |
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| CN103536486A (en) * | 2013-10-18 | 2014-01-29 | 桂林雪芙莲日化有限公司 | Anti-hair loss shampoo |
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| Title |
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| 侧柏叶、皂角外洗可以治脱发吗？;吴蓓玲;《中医健康养生》;20170531(第5期);第50-51页，尤其是第50页右栏第2段和第51页左栏第1段 |
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