CN107496462A - A kind of Chinese medicine composition with warming kidney and enhancing body effect and its production and use - Google Patents
A kind of Chinese medicine composition with warming kidney and enhancing body effect and its production and use Download PDFInfo
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- CN107496462A CN107496462A CN201710883970.4A CN201710883970A CN107496462A CN 107496462 A CN107496462 A CN 107496462A CN 201710883970 A CN201710883970 A CN 201710883970A CN 107496462 A CN107496462 A CN 107496462A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention discloses a kind of Chinese medicine composition with warming kidney and enhancing body effect and its production and use.Described Chinese medicine composition, it is made up of each Chinese medicine material of following percentage by weight meter：40 50% sparrow brains, 20 30% hippocampus, 10 20% silky ants and 10 20% pilose antlers, the percentage by weight sum of each Chinese medicine material is 100%.Research shows, it is antifatigue that Chinese medicine composition of the invention plays the role of weightening to mouse, and is effectively increased anoxia in mice life span.Meanwhile this Chinese medicine composition effectively extends the deficiency of yang mouse resistance to jelly time, SOD activity in deficiency of yang mouse content of hemoglobin and blood is increased, significantly increases deficiency of yang mouse sexual organ function.The it is proposed of the present invention improves deficiency of yang symptom, warming kidney and enhancing body provides a kind of new technological means to build up health.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and its production and use, more particularly to it is a kind of by sparrow brain, hippocampus,
Silky ant, pilose antler, by weight 40-50% sparrow brains, 20-30% hippocampus, 10-20% silky ants, 10-20% pilose antlers are configured to
Chinese medicine composition, its preparation method and the effect in warming kidney and enhancing body.The invention belongs to pharmaceutical technology field.
Background technology
The kidney being the origin of congenital constitution, Kidney-Yin kidney-Yang of being resided in kidney, the yang-energy of the main the whole body of kidney yang, and the card of the Yang-function insufficiency of kidneyzang then deficiency of yang comes out one after another.
Syndrome of deficiency of kidney yang is one of tcm clinical practice Common Syndromes type, and the performance of its syndrome is relatively stable and lasting.Kidney storing essence, the hair of main reproductive function
Wave and rely on kidney yin, kidney yang is realized.Kidney-yang deficiency person, its warm, reproduction, gasification function decline, and are declined with fatiguability, fecundity
See that disease is dialectical main points with the cold of insufficiency type.Discussion for syndrome of deficiency of kidney yang can trace back to《Interior warp》, such as《Plain Questions is fainted by a piece》Say " yang-energy
Decline in it is lower be then cold limbs, cloudy laboured breathing in it is lower be then heat jue ", " shaoyin syncope is inverse, and void is completely vomitted change, diarrhea with watery stool "；《Plain Questions is to very big
By a piece》Say " all cold spasms, come under kidney ".Above is the generality description of the disease and pathogenic characteristic to syndrome of deficiency of kidney yang.At present
The medicine that fatiguability, chilly and reproductive function caused by the treatment deficiency of yang decline even is short of, therefore a kind of warming kidney and enhancing body medicine
Research and development as yang deficiency patient active demand.
There is the effect of more Chinese medicine has had been found warming kidney and enhancing body, wherein also include numb sparrow brain, hippocampus, black ant certainly
Ant, pilose antler.Sparrow brain, it is sweet mild-natured, return kidney channel, can kidney tonifying Xing Yang, moisturizing myogenic.Cure mainly impotence due to deficiency of the kidney；Hippocampus, return kidney channel,
It is sweet, it is warm-natured, can tonifying kidney and strengthening yang,《Compendium of Materia Medica》Record in " hippocampus warming the kidney, establishing-Yang road ".Meanwhile《Book on Chinese herbal medicine is newly organized》Also refer to
" hippocampus enters the kidney channel gate of vitality, is specially apt to Xing Yang, work(is no less than fur seal, all can vigorous growth Yang Dao " no matter who knows hippocampus male and female；Ant,
Determining it has that the effect of mending body strong physique is powerful,《Compendium of Materia Medica》It is middle early to record that " ant power is maximum, body iron, the people such as can lift and eat
The beneficial strength of energy, damp color ".《Class clinical drug application》In also record：" property is sweet, flat, after being ill short wind, postpartum woman's milk
Shortage uses it.”；Pilose antler is not yet ossified on deer head and the young horn with fine hair.Main product is in Jilin, Heilungkiang, Liaoning, Inner Mongol, new
The ground such as boundary, Qinghai.Pilose antler, it is sweet, salty to return, it is warm-natured, return kidney, Liver Channel.The effect of main is kidney-replenishing, benefiting essence-blood, strengthening the bones and muscles, tune
Punching times, torr sore poison etc..
Warming kidney and enhancing body is mainly for the purpose of strengthening male's constitution, antifatigue, raising fecundity.Moreover, treatment at present
" deficiency of yang " of male and based on warming kidney and enhancing body.It is in Chinese medicine to have warming kidney and enhancing body effect more, but a herb can not
Improve " deficiency of yang " all symptoms.The present invention attempts to prove sparrow brain, hippocampus, silky ant, pilose antler according to 40-50% sparrow brains, 20-
30% hippocampus, 10-20% silky ants, the composition that 10-20% pilose antler percentage by weights are configured to can build up health, and improve the deficiency of yang
Symptom, it is the novel drugs of a warming kidney and enhancing body, hope is brought for yang deficiency patient.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of Chinese medicine composition and its system with warming kidney and enhancing body effect
Preparation Method.The Chinese medicine composition can effectively build up health, and for preventing and treating various symptoms caused by the deficiency of yang.
In order to achieve the above object, present invention employs following technological means：
The composition of four kinds of sparrow brain, hippocampus, silky ant, pilose antler Chinese medicines is divided into low, high dose by the present inventor
(0.02ml/g and 0.04ml/g), respectively to mouse stomach, by largely test card said composition can effectively increase weight it is antifatigue；
Meanwhile, it is capable to significantly extend time-to-live of the mouse in closed container, strengthen mouse hypoxia-bearing capability；Also, give the deficiency of yang
After low in mouse, high dose said composition, medicine can effectively lift the deficiency of yang mouse blood while extension mouse resistance to jelly time
Lactoferrin content and blood SOD activity.In deficiency of yang mouse sexual organ Function detection, inventor has found low, high dose combination
Thing can substantially shorten " deficiency of yang " mouse eclipse period of penile erection.At the same time, low, high dose composition can effectively improve sun
The organ coefficient of empty mouse seminal fluid capsule-prostate, testis and preputial gland, and low, high dose composition effectively increases " sun
The sperm quantity of void " mouse.
Herein study on the basis of, the present invention propose a kind of Chinese medicine composition with warming kidney and enhancing body effect, its by with
Each Chinese medicine material of lower percentage by weight meter is made：40-50% sparrow brains, 20-30% hippocampus, 10-20% silky ants and 10-
20% pilose antler, the percentage by weight sum of each Chinese medicine material is 100%.
Wherein, it is preferred that described Chinese medicine composition is made up of each Chinese medicine material of following percentage by weight meter：45% fiber crops
Sparrow brain, 25% hippocampus, 15% silky ant and 15% pilose antler.
Further, the invention also provides a kind of method for preparing the Chinese medicine composition, described method include with
Lower step：
(1) each Chinese medicine material is weighed according to described percentage by weight；
(2) Chinese medicine material that step (1) weighs is ground into coarse powder, mixes, add water to cook 2-3 times, each 1-3 hours,
Merge the filtered fluid after decocting 2-3 times, concentration, produce.
Further, the invention also provides described Chinese medicine composition is preparing antifatigue, the enhancing resist oxygen lack that increases weight
Purposes in ability and prevention and treatment deficiency of yang medicine.
Wherein, it is preferred that described medicine can be lifted content of hemoglobin and blood SOD activity in yang deficiency patient body,
Shorten the eclipse period of penile erection of yang deficiency patient, improve the internal organs system of yang deficiency patient seminal fluid capsule-prostate, testis and preputial gland
The sperm quantity of number, increase yang deficiency patient.
A kind of pharmaceutical preparation with warming kidney and enhancing body effect, its be by into described Chinese medicine composition add preparation into
Auxiliary material needed for type, clinically suitable various preparations are made according to pharmaceutical preparation conventional method.
Wherein, it is preferred that described pharmaceutical preparation is capsule, pill, granule, tablet or oral liquid.
Embodiment
The invention will now be further described with reference to specific embodiments, advantages of the present invention and feature intersection with description and
It is apparent.But these embodiments are only exemplary, do not form any restrictions to the scope of the present invention.People in the art
Member to the details and form of technical solution of the present invention it should be understood that can enter without departing from the spirit and scope of the invention
Row modifications or substitutions, but the replacement of these modifications is each fallen within protection scope of the present invention.
Embodiment 1, the preparation method of Chinese medicine composition
(1) each Chinese medicine material is weighed according to following percentage by weight；45% sparrow brain, 25% hippocampus, 15% silky ant with
And 15% pilose antler；
(2) Chinese medicine material that step (1) weighs is ground into coarse powder, mixed, added water to cook 3 times, 2 hours every time, merge 3
Filtered fluid after secondary decoction, every milliliter is concentrated into equivalent to 1g crude drugs.
Embodiment 2, the preparation method of Chinese medicine composition
(1) each Chinese medicine material is weighed according to following percentage by weight；40% sparrow brain, 25% hippocampus, 20% silky ant with
And 15% pilose antler；
(2) Chinese medicine material that step (1) weighs is ground into coarse powder, mixed, added water to cook 2 times, 2.5 hours every time, close
And the filtered fluid after 2 decoctions, every milliliter is concentrated into equivalent to 1g crude drugs.
Embodiment 3, the preparation method of Chinese medicine composition
(1) each Chinese medicine material is weighed according to following percentage by weight；50% sparrow brain, 20% hippocampus, 20% silky ant with
And 10% pilose antler；
(2) Chinese medicine material that step (1) weighs is ground into coarse powder, mixed, added water to cook 3 times, 2 hours every time, merge 3
Filtered fluid after secondary decoction, every milliliter is concentrated into equivalent to 1g crude drugs.
Embodiment 4, the preparation method of Chinese medicine composition
(1) each Chinese medicine material is weighed according to following percentage by weight；45% sparrow brain, 30% hippocampus, 10% silky ant with
And 15% pilose antler；
(2) Chinese medicine material that step (1) weighs is ground into coarse powder, mixed, added water to cook 2 times, 3 hours every time, merge 2
Filtered fluid after secondary decoction, every milliliter is concentrated into equivalent to 1g crude drugs.
The Chinese medicine composition of embodiment 5 put on weight, it is antifatigue in purposes
Body weight 20-30g male mouse of kunming is chosen in this experiment, is randomly divided into 3 groups, every group 20 and carries out mouse weight note
Record；The daily gavage physiological saline 0.04ml/g of blank control group mouse, the daily gavage Chinese medicine group simultaneously of medication low dose group mouse
Compound 0.02ml/g and 0.02ml/g physiological saline, the daily gavage Chinese medicine composition 0.04ml/g of medication high dose group mouse.Fill
Stomach is weighed to mouse again after 2 weeks, calculates mouse weight value added.Then, by mouse as depth of water 20cm, water temperature 20
DEG C, water meter area 2000cm2Swimming pool in, born a heavy burden before experiment by the 5% of actual weight, record mouse starts swimming to sinking to
The swimming time that the bottom is no longer struggled upwards.As a result as shown in table 1, low, high dose Chinese medicine composition is effectively increased Mice Body in
Weight, can be obviously prolonged the time of mice burden swimming drowning, have the function that antifatigue.Described Chinese medicine composition according to
It is prepared by the method for embodiment 1.
Mouse is increased weight the Chinese medicine composition of table 1 and antifatigue effect
Note：Low, high dose group compared with control group,**P<0.01
The purposes of embodiment 6, Chinese medicine composition in anoxic life span is extended
Mouse medication is same as Example 5.Small white mouse is put into the 250ml wide-mouth bottles containing 5g soda limes during experiment
It is interior closed, record the time-to-live.As a result as shown in table 2, when low, high dose Chinese medicine composition effectively extends anoxia in mice existence in
Between.
Influence of the Chinese medicine composition of table 2 to anoxia in mice life span
Note：Low, high dose group compared with control group,**P<0.01
The purposes of embodiment 7, Chinese medicine composition in deficiency of yang symptom is improved
1st, mouse model structure and medication
Body weight 20-30g male mouse of kunming is chosen, is randomly divided into 5 groups, Normal group, kidney-yang deficiency model group, the positive are right
According to group, Chinese medicine composition low dose group and Chinese medicine composition high dose group, every group 20,25mg/ is injected intraperitoneally in Normal group
Kg physiological saline, remaining each group are injected intraperitoneally hydrocortisone 25mg/kg, co-injection 10 days, build model of yang asthenia daily.Make
Mould simultaneously, note by Normal group and the daily gavage physiological saline 0.04ml/g of model of yang asthenia group, the daily abdominal cavity of positive drug control group
Testosterone propionate 5mg/kg, medication low dose group mouse while gavage Chinese medicine composition 0.02ml/g and 0.02ml/g distilled water are penetrated,
The daily gavage Chinese medicine composition 0.04ml/g of medication high dose group mouse.Described Chinese medicine composition is according to the method system of embodiment 1
It is standby.
2nd, Chinese medicine composition extends the deficiency of yang mouse resistance to jelly time
Iron sheet is made large, in advance in -10 DEG C of refrigerator precoolings, contain 20 cells in iron sheet box, often room is put into 1 small
White mouse, every group is put into 4, is placed in -10 DEG C of constant temperature refrigerators, observes 1 time within every 5 minutes, records the mouse survival time, be repeated 5 times, unites
Count the resistance to jelly time of every group of mouse.As a result as shown in table 3, when low, high dose Chinese medicine composition can be obviously prolonged mouse resistance to jelly
Between.
The influence for freezing the time resistance to " deficiency of yang " mouse of the Chinese medicine composition of table 3
Note：Low, high dose group compared with kidney-yang deficiency model group,**P<0.01；Low, high dose group and positive drug control group ratio
Compared with,#P<0.05
3rd, Chinese medicine composition increases SOD contents in deficiency of yang mouse hemoglobin and blood
Every group of mouse orbit takes blood, and content of hemoglobin uses colorimetric method for determining.SOD viability examinations use Li Shi polarogram oxygen
Electrode method.As a result as shown in table 4, low, high dose Chinese medicine composition can recover deficiency of yang mouse hemoglobin to a certain extent
Content and SOD contents.
Influence of the Chinese medicine composition of table 4 to " deficiency of yang " mouse hemoglobin and blood SOD activity
Note：Low, high dose group compared with kidney-yang deficiency model group,**P<0.01；Low, high dose group and positive drug control group ratio
Compared with,#P<0.05,##P<0.01
4th, Chinese medicine composition shortens deficiency of yang mouse eclipse period of penile erection, and improves deficiency of yang mouse sexual organ coefficient and sperm
Quantity
(1) eclipse period of penile erection detects：Instrument, electro photoluminescence mouse penis position 0.5s, frequency are used using pharmacology physiology
8Hz, voltage 10V.Record time for being erected completely to penis from the stimulation, is eclipse period of penile erection.As a result such as the institute of table 5
Show, low, high dose Chinese medicine composition can shorten deficiency of yang mouse eclipse period of penile erection.
(2) sexual organ coefficient detects：Mouse is weighed and put to death, and weighs preputial gland, testis, Prostato- seminal vesicle etc. at once
Organ weight, calculate reproductive organs organ coefficient.As a result as shown in table 5, kidney-yang deficiency model group sperm quantity substantially reduces, positive
Medicine testosterone propionate can dramatically increase sperm quantity, and low, high dose Chinese medicine composition can make deficiency of yang mice sperm number
Amount increase.
(3) sperm quantity detects：Epididymis on the left of separating mouse, is placed in and shreds in 20ml PBS solutions and blow and beat repeatedly, make
Sperm separate out, after 37 DEG C are incubated 30 minutes, sperm quantity is calculated with cell counter.As a result as shown in table 5, kidney-yang deficiency mould
Type group sperm quantity substantially reduces, and positive drug testosterone propionate can dramatically increase sperm quantity, low, high dose Chinese medicine composition
The increase of epididymal sperm quantity can be made.
Influence of the Chinese medicine composition of table 5 to " deficiency of yang " mouse eclipse period of penile erection and sexual organ
Note：Low, high dose group compared with kidney-yang deficiency model group,**P<0.01；Low, high dose group and positive controls ratio
Compared with,#P<0.05,##P<0.01。
Claims (7)
1. a kind of Chinese medicine composition with warming kidney and enhancing body effect, it is characterised in that by each Chinese medicine of following percentage by weight meter
Raw material is made：40-50% sparrow brains, 20-30% hippocampus, 10-20% silky ants and 10-20% pilose antlers, each Chinese medicine material
Percentage by weight sum is 100%.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that by each Chinese medicine material system of following percentage by weight meter
Into：45% sparrow brain, 25% hippocampus, 15% silky ant and 15% pilose antler.
3. Chinese medicine composition as claimed in claim 1, it is characterised in that described Chinese medicine composition is prepared in accordance with the following methods
Obtain：
(1) each Chinese medicine material is weighed according to the percentage by weight described in claim 1 or 2；
(2) Chinese medicine material that step (1) weighs is ground into coarse powder, mixes, add water to cook 2-3 times, each 1-3 hours, merged
Filtered fluid after 2-3 decoction, concentration, is produced.
4. Chinese medicine composition described in claim any one of 1-3 is preparing antifatigue weightening, enhancing hypoxia-bearing capability and pre-
Purposes in anti-and treatment deficiency of yang medicine.
5. purposes as claimed in claim 4, it is characterised in that described medicine can lift hemoglobin in yang deficiency patient body
Content and blood SOD activity, shorten the eclipse period of penile erection of yang deficiency patient, improve yang deficiency patient seminal fluid capsule-prostate, testis
Organ coefficient, the sperm quantity of increase yang deficiency patient with preputial gland.
6. a kind of pharmaceutical preparation with warming kidney and enhancing body effect, it is characterised in that to the Chinese medicine described in claim any one of 1-3
The auxiliary material needed for preparations shaping is added in composition, clinically suitable various preparations are made according to pharmaceutical preparation conventional method.
7. pharmaceutical preparation as claimed in claim 4, it is characterised in that described pharmaceutical preparation be capsule, pill, granule,
Tablet or oral liquid.
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| CN201710883970.4A CN107496462A (en) | 2017-09-26 | 2017-09-26 | A kind of Chinese medicine composition with warming kidney and enhancing body effect and its production and use |
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| CN201710883970.4A CN107496462A (en) | 2017-09-26 | 2017-09-26 | A kind of Chinese medicine composition with warming kidney and enhancing body effect and its production and use |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112426482A (en) * | 2020-10-12 | 2021-03-02 | 卡德尔·买买提 | Traditional Chinese medicine composition and honey paste for conditioning organism and refreshing and nourishing body and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095944A (en) * | 1993-06-04 | 1994-12-07 | 成胤祖 | Tonic wine with Yang-strengthening function |
| CN1537616A (en) * | 2003-10-22 | 2004-10-20 | 华方喜 | Yi-E-Jing tablet contg. extractives of ant and silk moth for nourishing kidney and tonifying yang |
-
2017
- 2017-09-26 CN CN201710883970.4A patent/CN107496462A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095944A (en) * | 1993-06-04 | 1994-12-07 | 成胤祖 | Tonic wine with Yang-strengthening function |
| CN1537616A (en) * | 2003-10-22 | 2004-10-20 | 华方喜 | Yi-E-Jing tablet contg. extractives of ant and silk moth for nourishing kidney and tonifying yang |
Non-Patent Citations (1)
| Title |
|---|
| 郑跃进，林荣臻: "龟龄集临床新用", 《中医药信息》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112426482A (en) * | 2020-10-12 | 2021-03-02 | 卡德尔·买买提 | Traditional Chinese medicine composition and honey paste for conditioning organism and refreshing and nourishing body and preparation method thereof |
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Application publication date: 20171222 |