CN107468872A - 一种治疗痛风樟木当归药浴液及其制备方法 - Google Patents
一种治疗痛风樟木当归药浴液及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗痛风樟木当归药浴液,由以下重量份的中草药原料制成:樟木屑30~40份,当归15~25份,乳香10~20份,没药10~15份,川芎5~10份,牛膝10~20份,苏木20~30份,狗脊10~15份,防风10~15份,独活5~10份,羌活5~10份,鸡血藤10~15份,马钱子10~15份,半夏10~20份,艾叶10~20份,红花3~6份,王不留行10~15份,大黄10~20份,海桐皮20~30份,葱须5~10份。本发明还公开了治疗痛风樟木当归药浴液的制备方法,主要采用原材料粉碎酶解、微生物发酵和超声波辅助乙醇浸提为主要步骤制成。本发明中草药原料来源广,价格低廉,配方科学合理,制备工艺简单,提取中草药功能性成分高,产品安全环保,对人体无任何副作用,治疗痛风效果显著。
Description
技术领域
本发明公开了一种药浴液,尤其涉及一种治疗痛风樟木当归药浴液及其制备方法,属中医中药领域。
背景技术
痛风又称高尿酸血症,属于关节炎的一种,又称代谢性关节炎,是一种因长期嘌呤代谢障碍、血尿酸增高引致组织损伤的一组疾病,具有发病率高、治愈难、反复发作等特点。痛风多发生于中老年人、肥胖者和脑力劳动者,其病理特点为高尿酸血症及由此引起的痛风性急性关节炎反复发作、痛风石沉积、痛风石性慢性关节炎、关节畸形、关节红肿、热痛、反复发作、关节活动不灵活为主要临床表现。常累及肾脏引起慢性间质性肾炎和尿酸肾结石形成。根据血中尿酸增高原因可分为原发性和继发性两大类。原发性痛风的病因是由于先天性嘌呤代谢紊乱所致,属遗传性。继发性痛风的病因,可由肾脏病、白血病、药物、食物等多种原因引起。
目前对于痛风的治疗多采用西药为主,常用的有秋水仙碱,非甾体类抗炎镇痛药,肾上腺糖皮质激素和丙磺舒等,此类西药虽然见效快,但大多只是起到缓解病痛的目的,难以达到根治的目的,停药后病痛很容易又复发,而且此类药物往往毒副作用比较大,可产生耐药性和抵抗性,长期服用可引起胃肠道反应,还可能导致白细胞减少、心脏功能受损、肝肾功能受损、精神抑郁、上行性麻痹、呼吸抑制、再生障碍性贫血、导致糖尿病等合并症。从中医的整体观念出发,用中医药整体辨证理念,治疗痛风疾病是较好的治疗方法。中药治疗本身的毒副作用大大减少,而且可降低西药服用量,克服长期单纯服用西药所带来的巨大毒副作用。但目前市场上治疗痛风的中成药虽有一定疗效,但中药药汤煎服过程复杂,功能性成分低,起效缓慢,疗程长,且对部分患者疗效不明显。当前大部分患者仍然只能靠大量服用毒副作用较大的西药来稳定病情,因此开发安全、高效、经济、新型的治疗痛风产品是十分有意义的工作。
药浴对人体具有独到功效,在中国已有几千年的历史,自古以来一直受医学界重视。药浴法是外治法之一,即用药液或含有药液水洗浴全身或局部的一种方法,其形式多种多样。药浴作用机理概而言之,药物作用于全身肌表、局部、患处,并经吸收,循行经络血脉,内达脏腑,由表及里,因而产生效应。药浴洗浴,可起到疏通经络、活血化淤、驱风散寒、清热解毒、消肿止痛、调整阴阳、协调脏腑、通行气血、濡养全身等养生功效。药浴避免了药物对脾胃的刺激和对肝脏的损害,使药物有效成分通过皮肤吸收而发挥功效,是防治各种慢性疾病和养生保健的理想方法。但目前中草药治疗痛风药浴在应用尚未实现规模化和产业化,主要问题是中草药配伍不合理、功能成分提取率低、难以工业化生产、功效不显著等弊端,因此开发新型的安全有效治疗痛风药浴具有重要的现实意义。
发明内容
本发明的目的在于根据现有治疗痛风产品和技术存在的上述问题,开发安全有效的治疗痛风药浴,该中药药浴制作简单,疗程短,疗效确切,且成本较低。
为了实现上述目的,本发明采用以下技术方案:
一种治疗痛风樟木当归药浴液,由以下重量份的中草药原料制成:樟木屑30~40份,当归15~25份,乳香10~20份,没药10~15份,川芎5~10份,牛膝10~20份,苏木20~30份,狗脊10~15份,防风10~15份,独活5~10份,羌活5~10份,鸡血藤10~15份,马钱子10~15份,半夏10~20份,艾叶10~20份,红花3~6份,王不留行10~15份,大黄10~20份,海桐皮20~30份,葱须5~10份。
本发明治疗痛风樟木当归药浴液的制备方法,包括如下步骤:
(1)备料:剔除中草药原料中的杂质,霉变和生虫原料后,按照上述比例备料;
(2)原料处理:将中草药原料清洗干净,在70~80 ℃下,鼓风烘干后,粉碎机粉碎,过60~100目筛,混匀,得复合中草药原料;
(3)混料酶解:将步骤(2)所得复合中草药原料加水至固液比1:4~6,按3.0~4.0 g/L、2.0~3.0 g/L比例分别添加非淀粉多糖酶、纤维素酶,在800~1200 W超声波辅助作用下,在40~50 ℃条件下协同酶解60~100 min;
(4)微生物发酵:向步骤(3)所得酶解浸提液中加入3~6%活化后的双歧杆菌(活菌数≥200亿/ml),厌氧条件下发酵12~18 h,控制发酵温度28~35 ℃;
(5)离心:发酵结束后离心分离固体残渣与上清液,上清液在125 ℃高温下,灭菌10~15秒;
(6)超声波辅助乙醇浸提:向固体残渣中加入3~5倍浓度为50~60%的乙醇,在800~1200 W超声波辅助条件下,浸提90~120 min,浸提温度60~75 ℃;
(7)离心:浸提结束后离心分离固体残渣和醇提液;
(8)浓缩蒸馏:将醇提液浓缩蒸馏回收乙醇;
(9)混合:将回收乙醇后的浸提液与发酵上清液混合;
(10)过滤:将混合液经硅藻过滤机过滤除去其中的杂质及不溶物即得治疗痛风樟木当归药浴液。
本发明提供一种治疗痛风樟木当归药浴液,结合配方中各中草药的特性,采用中医辨证理论所研制,配方科学合理,各组分之间协同作用,经长期使用证明本发明对痛风有良好的疗效。本发明的优势在于:(1)产品使用药浴时药物不需经过体内吸收,将药效直接作用于患处,安全环保,药性平和,对人体无任何副作用;(2)产品具有宜人的中草药清香,使用便捷,使用时只需取本产品按1:400~600比例调入热浴水中,便可进行浸泡洗浴;(3)与药浴粉单纯添加相比,本发明采用原材料粉碎酶解、微生物发酵和超声波辅助乙醇浸提为主要制备步骤,提高了中草药活性成分的浸出率,治疗痛风功效显著;(4)本发明中原料来源广,价格低廉,生产加工工艺简单,适合规模化生产。
具体实施方式
下面通过具体实施方式对本发明做进一步的描述。在本发明中,若非特指,所有百分比均为重量单位,所有设备和原料均可从市场购得或是本行业常用的,下述实施例中的方法,如无特别说明,均为本领域常规方法。
实施例1
一种治疗痛风樟木当归药浴液,由以下各组分的原料制成:樟木屑,当归,乳香,没药,川芎,牛膝,苏木,狗脊,防风,独活,羌活,鸡血藤,马钱子,半夏,艾叶,红花,王不留行,大黄,海桐皮,葱须。中草药原料中各组分的具体配比如表1所示。
本发明治疗痛风樟木当归药浴液的制备方法,包括如下步骤:
(1)备料:剔除中草药原料中的杂质,霉变和生虫原料后,按照上述比例备料;
(2)原料处理:将中草药原料清洗干净,在78 ℃下,鼓风烘干后,粉碎机粉碎,过80目筛,混匀,得复合中草药原料;
(3)混料酶解:将步骤(2)所得复合中草药原料加水至固液比1:6,按3.0 g/L、3.0 g/L比例分别添加非淀粉多糖酶、纤维素酶,在1000 W超声波辅助作用下,在48 ℃条件下协同酶解75 min;
(4)微生物发酵:向步骤(3)所得酶解浸提液中加入5%活化后的双歧杆菌(活菌数≥200亿/ml),厌氧条件下发酵16 h,控制发酵温度28 ℃;
(5)离心:发酵结束后离心分离固体残渣与上清液,上清液在125 ℃高温下,灭菌10秒;
(6)超声波辅助乙醇浸提:向固体残渣中加入5倍浓度为50%的乙醇,在900 W超声波辅助条件下,浸提110 min,浸提温度62 ℃;
(7)离心:浸提结束后离心分离固体残渣和醇提液;
(8)浓缩蒸馏:将醇提液浓缩蒸馏回收乙醇;
(9)混合:将回收乙醇后的浸提液与发酵上清液混合;
(10)过滤:将混合液经硅藻过滤机过滤除去其中的杂质及不溶物即得治疗痛风樟木当归药浴液。
实施例2
一种治疗痛风樟木当归药浴液,由以下各组分的原料制成:樟木屑,当归,乳香,没药,川芎,牛膝,苏木,狗脊,防风,独活,羌活,鸡血藤,马钱子,半夏,艾叶,红花,王不留行,大黄,海桐皮,葱须。中草药原料中各组分的具体配比如表1所示。
本发明治疗痛风樟木当归药浴液的制备方法,包括如下步骤:
(1)备料:剔除中草药原料中的杂质,霉变和生虫原料后,按照上述比例备料;
(2)原料处理:将中草药原料清洗干净,在75 ℃下,鼓风烘干后,粉碎机粉碎,过60目筛,混匀,得复合中草药原料;
(3)混料酶解:将步骤(2)所得复合中草药原料加水至固液比1:4,按3.5 g/L、2.0 g/L比例分别添加非淀粉多糖酶、纤维素酶,在900 W超声波辅助作用下,在43 ℃条件下协同酶解85 min;
(4)微生物发酵:向步骤(3)所得酶解浸提液中加入4%活化后的双歧杆菌(活菌数≥200亿/ml),厌氧条件下发酵14 h,控制发酵温度32 ℃;
(5)离心:发酵结束后离心分离固体残渣与上清液,上清液在125 ℃高温下,灭菌12秒;
(6)超声波辅助乙醇浸提:向固体残渣中加入4倍浓度为60%的乙醇,在1100 W超声波辅助条件下,浸提100 min,浸提温度67 ℃;
(7)离心:浸提结束后离心分离固体残渣和醇提液;
(8)浓缩蒸馏:将醇提液浓缩蒸馏回收乙醇;
(9)混合:将回收乙醇后的浸提液与发酵上清液混合;
(10)过滤:将混合液经硅藻过滤机过滤除去其中的杂质及不溶物即得治疗痛风樟木当归药浴液。
实施例3
一种治疗痛风樟木当归药浴液,由以下各组分的原料制成:樟木屑,当归,乳香,没药,川芎,牛膝,苏木,狗脊,防风,独活,羌活,鸡血藤,马钱子,半夏,艾叶,红花,王不留行,大黄,海桐皮,葱须。中草药原料中各组分的具体配比如表1所示。
本发明治疗痛风樟木当归药浴液的制备方法,包括如下步骤:
(1)备料:剔除中草药原料中的杂质,霉变和生虫原料后,按照上述比例备料;
(2)原料处理:将中草药原料清洗干净,在72 ℃下,鼓风烘干后,粉碎机粉碎,过100目筛,混匀,得复合中草药原料;
(3)混料酶解:将步骤(2)所得复合中草药原料加水至固液比1:5,按4.0 g/L、2.5 g/L比例分别添加非淀粉多糖酶、纤维素酶,在1100 W超声波辅助作用下,在45 ℃条件下协同酶解95 min;
(4)微生物发酵:向步骤(3)所得酶解浸提液中加入6%活化后的双歧杆菌(活菌数≥200亿/ml),厌氧条件下发酵12 h,控制发酵温度30 ℃;
(5)离心:发酵结束后离心分离固体残渣与上清液,上清液在125 ℃高温下,灭菌15秒;
(6)超声波辅助乙醇浸提:向固体残渣中加入3倍浓度为55%的乙醇,在1000 W超声波辅助条件下,浸提90 min,浸提温度72 ℃;
(7)离心:浸提结束后离心分离固体残渣和醇提液;
(8)浓缩蒸馏:将醇提液浓缩蒸馏回收乙醇;
(9)混合:将回收乙醇后的浸提液与发酵上清液混合;
(10)过滤:将混合液经硅藻过滤机过滤除去其中的杂质及不溶物即得治疗痛风樟木当归药浴液。
表1. 各实施例中草药原料的组成配比
序号 | 组分 | 实施例1 | 实施例2 | 实施例3 |
1 | 樟木屑(份) | 35 | 38 | 32 |
2 | 当归(份) | 17 | 19 | 23 |
3 | 乳香(份) | 17 | 15 | 13 |
4 | 没药(份) | 12 | 14 | 13 |
5 | 川芎(份) | 6 | 8 | 7 |
6 | 牛膝(份) | 19 | 16 | 14 |
7 | 苏木(份) | 28 | 25 | 22 |
8 | 狗脊(份) | 12 | 15 | 13 |
9 | 防风(份) | 14 | 12 | 13 |
10 | 独活(份) | 8 | 9 | 6 |
11 | 羌活(份) | 8 | 6 | 7 |
12 | 鸡血藤(份) | 14 | 12 | 13 |
13 | 马钱子(份) | 14 | 12 | 13 |
14 | 半夏(份) | 17 | 16 | 19 |
15 | 艾叶(份) | 13 | 14 | 18 |
16 | 红花(份) | 5 | 4 | 6 |
17 | 王不留行(份) | 12 | 14 | 13 |
18 | 大黄(份) | 19 | 15 | 13 |
19 | 海桐皮(份) | 26 | 25 | 23 |
20 | 葱须(份) | 6 | 7 | 9 |
21 | 总和(份) | 302 | 296 | 290 |
尽管为达到说明目的,以上所述为本发明的优选实施例而已,并不用于限制本发明,尽管参照前述实施例对本发明进行了详细的说明,对于本领域的技术人员来说,其依然可以对前述各实施例记载的技术方案进行修改,或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (2)
1.一种治疗痛风樟木当归药浴液,其特征在于,由以下重量份的中草药原料制成:樟木屑30~40份,当归15~25份,乳香10~20份,没药10~15份,川芎5~10份,牛膝10~20份,苏木20~30份,狗脊10~15份,防风10~15份,独活5~10份,羌活5~10份,鸡血藤10~15份,马钱子10~15份,半夏10~20份,艾叶10~20份,红花3~6份,王不留行10~15份,大黄10~20份,海桐皮20~30份,葱须5~10份。
2.一种如权利要求1所述的治疗痛风樟木当归药浴液的制备方法,其特征在于,包括以下步骤:
(1)备料:剔除中草药原料中的杂质,霉变和生虫原料后,按照上述比例备料;
(2)原料处理:将中草药原料清洗干净,在70~80 ℃下,鼓风烘干后,粉碎机粉碎,过60~100目筛,混匀,得复合中草药原料;
(3)混料酶解:将步骤(2)所得复合中草药原料加水至固液比1:4~6,按3.0~4.0 g/L、2.0~3.0 g/L比例分别添加非淀粉多糖酶、纤维素酶,在800~1200 W超声波辅助作用下,在40~50 ℃条件下协同酶解60~100 min;
(4)微生物发酵:向步骤(3)所得酶解浸提液中加入3~6%活化后的双歧杆菌(活菌数≥200亿/ml),厌氧条件下发酵12~18 h,控制发酵温度28~35 ℃;
(5)离心:发酵结束后离心分离固体残渣与上清液,上清液在125 ℃高温下,灭菌10~15秒;
(6)超声波辅助乙醇浸提:向固体残渣中加入3~5倍浓度为50~60%的乙醇,在800~1200 W超声波辅助条件下,浸提90~120 min,浸提温度60~75 ℃;
(7)离心:浸提结束后离心分离固体残渣和醇提液;
(8)浓缩蒸馏:将醇提液浓缩蒸馏回收乙醇;
(9)混合:将回收乙醇后的浸提液与发酵上清液混合;
(10)过滤:将混合液经硅藻过滤机过滤除去其中的杂质及不溶物即得治疗痛风樟木当归药浴液。
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CN110585396A (zh) * | 2019-09-29 | 2019-12-20 | 蔡良英 | 一种外敷治疗痛风祛除痛风石的组合中药及其应用方法 |
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CN110585396A (zh) * | 2019-09-29 | 2019-12-20 | 蔡良英 | 一种外敷治疗痛风祛除痛风石的组合中药及其应用方法 |
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