CN107468733A - One kind improves rare ginsenoside RK1The pseudo-ginseng steaming method of conversion ratio - Google Patents
One kind improves rare ginsenoside RK1The pseudo-ginseng steaming method of conversion ratio Download PDFInfo
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- CN107468733A CN107468733A CN201710837924.0A CN201710837924A CN107468733A CN 107468733 A CN107468733 A CN 107468733A CN 201710837924 A CN201710837924 A CN 201710837924A CN 107468733 A CN107468733 A CN 107468733A
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- pseudo
- ginseng
- ginsenoside
- conversion ratio
- rare
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
Abstract
The present invention relates to one kind to improve rare ginsenoside RK1The pseudo-ginseng steaming method of conversion ratio, mixes thoroughly to steam in 105 120 DEG C 24 hours and produces after pseudo-ginseng is crushed with zeolite powder.Method provided by the invention can improve rare saponin(e RK using zeolite as auxiliary agent is processed1In three kinds of rare ginsenoside RK1、RG5And RZ1Accounting, to rare saponin(e RK1With certain selectivity, ginsenoside RK in pseudo-ginseng is steamed so as to improve1Content.
Description
Technical field
The present invention relates to prepared slices of Chinese crude drugs processing, more particularly to a kind of raising rare ginsenoside RK1The pseudo-ginseng of conversion ratio is steamed
Method processed.
Background technology
The researchs such as Shi Sun find that ripe pseudo-ginseng (Red notoginseng, steamed and formed by raw sangqi ginseng high temperature) is than raw by three
Seven have the rare saponin(e of higher amount, and ripe Notogineng Extract has stronger antitumor activity.Research discovery, ripe pseudo-ginseng
The enhancing of this antitumor activity may (bibliography relevant with the rare saponin(e of high content：Red notoginseng:
higher ginsenoside content and stronger anticancer potential than Asian and
American ginseng,Food Chemistry,2011)。
Elevated rare saponin(e is mainly by ginsenoside RG in pseudo-ginseng in ripe pseudo-ginseng3Etc. common saponin(e during steaming
Generation is dehydrated and/or the generation of desugar side chain.With rare ginsenoside RK1、RG5And RZ1Exemplified by, ginsenoside RG3C20 hydroxyls
Elimination reaction occurs with C21 hydrogen and obtains ginsenoside RK1, ginsenoside RG3C20 hydroxyls and C22 hydrogen elimination reaction occur obtain
Ginsenoside RG5And RZ1, ginsenoside RK1With RG5、RZ1For double-bond positional isomerization, ginsenoside RG5With RZ1It is that double bond is suitable anti-
Isomery.The chemical structural formula and forming feature of each saponin(e are as follows：
The steaming method that Shi Sun etc. are used for：Raw sangqi ginseng is steamed 4 hours in 120 DEG C.It is but dilute in this method
There is ginsenoside RK1Content it is relatively low, be not suitable for selectivity prepare rare ginsenoside RK1。
The content of the invention
It is an object of the invention to provide one kind to improve rare ginsenoside RK1The pseudo-ginseng steaming method of conversion ratio.
To achieve the above object, the invention provides following technical scheme：
One kind improves rare ginsenoside RK1The pseudo-ginseng steaming method of conversion ratio：Mixed thoroughly after pseudo-ginseng is crushed with zeolite powder
Steam.
Preferably, 105-120 DEG C steams 2-4 hours.
Preferably, 30-50 mesh sieves are crossed after pseudo-ginseng crushes.
Preferably, zeolite powder crushed 30-50 mesh sieves by zeolite.
Preferably, it is steam sterilization pan to steam equipment.
Zeolite rare ginsenoside RK in raising steams pseudo-ginseng as auxiliary agent1Application in terms of conversion ratio.
Advantage of the present invention：
Method provided by the invention can improve rare saponin(e RK using zeolite as auxiliary agent is processed1In three kinds of rare ginseng soaps
Glycosides RK1、RG5And RZ1Accounting, to rare saponin(e RK1With certain selectivity, ginseng in pseudo-ginseng is steamed so as to improve
Saponin(e RK1Content.
Brief description of the drawings
Fig. 1 is that each embodiment steams rare saponin(e conversion ratio (%) in pseudo-ginseng.
Fig. 2 is that each embodiment steams RK in pseudo-ginseng1Selection rate (%).
Embodiment
Embodiment 1：Pseudo-ginseng is mixed thoroughly with zeolite powder after crushing and steamed
Equipment is steamed using the rich news full-automatic vertical pressure steam sterilizer in Shanghai, model YXQ-LS-75S II.
Pseudo-ginseng is 70, purchased from Yunnan mountain of papers.First smash, then beat powder, cross 40 mesh sieves.
Zeolite powder is crushed by zeolite and prepared, and crosses 40 mesh sieves.
1 kilogram of Radix Notoginseng powder is well mixed with 1 kilogram of zeolite powder, is then wrapped up with hospital gauze, is placed in steam sterilization pan
In, design temperature is 110 DEG C, and steaming time is 3 hours.
After steaming end, mixed powder is placed in 50 DEG C of baking ovens and is dried overnight.
Embodiment 2：Pseudo-ginseng is mixed thoroughly with zeolite powder after crushing and steamed
Equipment is steamed using the rich news full-automatic vertical pressure steam sterilizer in Shanghai, model YXQ-LS-75S II.
Pseudo-ginseng is 70, purchased from Yunnan mountain of papers.First smash, then beat powder, cross 30 mesh sieves.
Zeolite powder is crushed by zeolite and prepared, and crosses 30 mesh sieves.
1 kilogram of Radix Notoginseng powder is well mixed with 1 kilogram of zeolite powder, is then wrapped up with hospital gauze, is placed in steam sterilization pan
In, design temperature is 105 DEG C, and steaming time is 4 hours.
After steaming end, mixed powder is placed in 50 DEG C of baking ovens and is dried overnight.
Embodiment 3：Pseudo-ginseng is mixed thoroughly with zeolite powder after crushing and steamed
Equipment is steamed using the rich news full-automatic vertical pressure steam sterilizer in Shanghai, model YXQ-LS-75S II.
Pseudo-ginseng is 70, purchased from Yunnan mountain of papers.First smash, then beat powder, cross 50 mesh sieves.
Zeolite powder is crushed by zeolite and prepared, and crosses 50 mesh sieves.
1 kilogram of Radix Notoginseng powder is well mixed with 1 kilogram of zeolite powder, is then wrapped up with hospital gauze, is placed in steam sterilization pan
In, design temperature is 120 DEG C, and steaming time is 2 hours.
After steaming end, mixed powder is placed in 50 DEG C of baking ovens and is dried overnight.
Comparative example：Pseudo-ginseng individually steams after crushing
Equipment is steamed using the rich news full-automatic vertical pressure steam sterilizer in Shanghai, model YXQ-LS-75S II.
Pseudo-ginseng is 70, purchased from Yunnan mountain of papers.First smash, then beat powder, cross 40 mesh sieves.
Radix Notoginseng powder is wrapped up with hospital gauze, is placed in steam sterilization pan, design temperature is 110 DEG C, and steaming time is 3 small
When.
After steaming end, mixed powder is placed in 50 DEG C of baking ovens and is dried overnight.
Effect example：The measure of rare saponin(e conversion ratio
The preparation of need testing solution：Take each embodiment preparation respectively steams drying product, with methanol circumfluence distillation 3
It is secondary, 2 hours every time, filtrate is collected by filtration and produces.
Using above-mentioned need testing solution as solution to be analyzed, 20 (S)-Rg are determined using HPLC-VWD3、20(R)-Rg3、RK1、
RG5And RZ1Content, then calculate rare saponin(e conversion ratio (%) and RK respectively according to equation below1Selection rate (%)：
Measurement result is as shown in following table and Fig. 1,2：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example | |
| Rare saponin(e conversion ratio (%) | 53.9% | 55.7% | 56.3% | 54.8% |
| RK1Selection rate (%) | 90.2% | 87.8% | 88.5% | 32.3% |
It is can be seen that by the contrast of embodiment 1 and comparative example in method provided by the invention, although zeolite powder can not
Total rare saponin(e conversion ratio is improved, but is favorably improved ginsenoside RG3To rare ginsenoside RK1Selective conversion, to rare
Ginsenoside RK1With higher selectivity, rare ginsenoside RK can be selectively improved1Content.
As fully visible, method provided by the invention can improve rare saponin(e RK using zeolite as auxiliary agent is processed1It is dilute at three kinds
There is ginsenoside RK1、RG5And RZ1Accounting, to rare saponin(e RK1With certain selectivity, three are steamed so as to improve
Ginsenoside RK in seven1Content.
Claims (6)
1. one kind improves rare ginsenoside RK1The pseudo-ginseng steaming method of conversion ratio, it is characterised in that：After pseudo-ginseng is crushed with boiling
Stone flour, which is mixed thoroughly, to be steamed.
2. according to the method for claim 1, it is characterised in that：105-120 DEG C steams 2-4 hours.
3. steaming method according to claim 1, it is characterised in that：Pseudo-ginseng crosses 30-50 mesh sieves after crushing.
4. steaming method according to claim 1, it is characterised in that：Zeolite powder crushed 30-50 mesh sieves by zeolite.
5. according to any described steaming methods of claim 1-4, it is characterised in that：It is steam sterilization pan to steam equipment.
6. zeolite rare ginsenoside RK in raising steams pseudo-ginseng as auxiliary agent1Application in terms of conversion ratio.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710837924.0A CN107468733A (en) | 2017-09-18 | 2017-09-18 | One kind improves rare ginsenoside RK1The pseudo-ginseng steaming method of conversion ratio |
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| CN201710837924.0A CN107468733A (en) | 2017-09-18 | 2017-09-18 | One kind improves rare ginsenoside RK1The pseudo-ginseng steaming method of conversion ratio |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110448612A (en) * | 2019-09-05 | 2019-11-15 | 长春三德天晟科技有限公司 | A kind of intermediate preparation for the Chinese traditional medicines depressing lipid composition drug effect improving the ingredient containing Radix Notoginseng |
-
2017
- 2017-09-18 CN CN201710837924.0A patent/CN107468733A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110448612A (en) * | 2019-09-05 | 2019-11-15 | 长春三德天晟科技有限公司 | A kind of intermediate preparation for the Chinese traditional medicines depressing lipid composition drug effect improving the ingredient containing Radix Notoginseng |
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Application publication date: 20171215 |