CN107467664A - A kind of pure food formulation formula and method for treating cardiovascular and cerebrovascular - Google Patents
A kind of pure food formulation formula and method for treating cardiovascular and cerebrovascular Download PDFInfo
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- CN107467664A CN107467664A CN201710766281.5A CN201710766281A CN107467664A CN 107467664 A CN107467664 A CN 107467664A CN 201710766281 A CN201710766281 A CN 201710766281A CN 107467664 A CN107467664 A CN 107467664A
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- 238000000034 method Methods 0.000 title claims abstract description 22
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- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of pure food formulation formula and method for treating cardiovascular and cerebrovascular, including 90% main material and 10% auxiliary material, main material to include：50 70 parts of Semen sojae atricolor extract, 30 50 parts of money willow buddings extract；Auxiliary material includes：60 parts of ethanol, 10 parts of n-hexane, 10 parts of methanol, 5 parts of saline solution, surplus are pure water；Using black soya bean, money willow buddings as raw material, by being extracted to the materials such as the anthocyanidin in black soya bean, isoflavones and money willow buddings water, it is particle, aqueous solvent, capsule or pill that said extracted thing is mixed into food formulation, different preparations can be fabricated to as needed, in actual use, each food materials of the invention are cheap, can not only treat cardiovascular and cerebrovascular, acceptable effective three high drop, can be long-term use of.
Description
Technical field
The present invention relates to the food materials technical field for treating cardio-cerebral vascular disease, specially a kind of pure food for treating cardiovascular and cerebrovascular
Product pharmaceutical formulation and method.
Background technology
Cardiovascular and cerebrovascular is surprisingly a kind of serious threat mankind, the common disease of particularly more than 50 years old the elderly's health, i.e.,
Make, using treatment means most advanced, perfect at present, can still have more than 50% cerebrovas-cularaccident survivor life can not be complete
Take care of oneself！The number that cardiovascular and cerebrovascular disease is died from the whole world every year is up to 15,000,000 people, and it is the first to occupy the various causes of the death.Cardiovascular and cerebrovascular disease
Turn into human death's cause of disease highest number one killer, and " the noiseless demon " of health of people！Cardiovascular and cerebrovascular disease is mainly former
Caused by being exactly the improper metabolism of vascular smooth muscle cell, vascular tissue and human body other be organized in it is complete in some cycles
Into the process of metabolism, but because new cell tissue can not be formed normally, make vascular wall exist in itself " defect " because
This be easy for produce inflammation vessel retraction it is not smooth, be like a worm-eaten old pipeline, have at any time obstruction or rupture
May.Blood vessel is the important channel of blood circulation, while it is also dominated by nervous system, therefore nervous system is abnormal also can
Enough cause the disorder of blood supply.Furthermore due to long-time eating habit problem, lipid is excessive in diet, and alcohols is excessive.Do not have again simultaneously
The metabolism for having rational motion to promote lipid alcohols, causes internal lipid alcohols material gradually to increase；Plus with age,
Human secretory antioxidant enzyme (such as superoxide dismutase SOD) decreased capacity, cause the horizontal rise of interior free yl, make blood
Vascular wall is deposited on after ldl cholesterol oxidation in fat, long blocks capillary, over time,
The mineral ion that lipid alcohols material easily and in vivo dissociates combines, and forms thrombus, produces cardiovascular and cerebrovascular disease.Therefore need
Design a kind of new bio technique preparation for treating cardiovascular and cerebrovascular.
The content of the invention
It is an object of the invention to provide a kind of pure food formulation formula and method for treating cardiovascular and cerebrovascular, can not only control
Treatment cardiovascular and cerebrovascular, acceptable effective three high drop, to solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides following technical scheme：A kind of pure food formulation for treating cardiovascular and cerebrovascular is matched somebody with somebody
Side, including 90% main material and 10% auxiliary material, the raw material that main material is matched by following parts by weight form：Black soya bean extracts
Thing 50-70 parts, money willow buddings extract 30-50 parts；The raw material that auxiliary material is matched by following parts by weight forms：60 parts of ethanol,
10 parts of n-hexane, 10 parts of methanol, 5 parts of saline solution, surplus are pure water.
Preferably, the Semen sojae atricolor extract includes anthocyanidin, isoflavones, soap alcohol, protein, fat, vitamin and micro
Element.
Preferably, the money willow buddings extract be mainly money willow buddings it is modulated, filtering after willow buddings water.
Preferably, including main material：50 parts of Semen sojae atricolor extract, 50 parts of money willow buddings extract；Auxiliary material：60 parts of ethanol,
10 parts of n-hexane, 10 parts of methanol, 5 parts of saline solution, surplus are pure water.
Preferably, including main material：70 parts of Semen sojae atricolor extract, 30 parts of money willow buddings extract；Auxiliary material：60 parts of ethanol,
10 parts of n-hexane, 10 parts of methanol, 5 parts of saline solution, surplus are pure water.
Preferably, including main material：60 parts of Semen sojae atricolor extract, 40 parts of money willow buddings extract；Auxiliary material：60 parts of ethanol,
10 parts of n-hexane, 10 parts of methanol, 5 parts of saline solution, surplus are pure water.
The present invention provides another technical solution：A kind of method for the pure food formulation for treating cardiovascular and cerebrovascular, including it is following
Step：
S1：Long 6-12mm, diameter 5-9mm, surface black or grey black are selected by above-mentioned parts by weight, it is smooth or have wrinkle
Line, has gloss, there is the black soya bean of yellowish white oblong hilum side, rinsed with clear water, and dries to use in 30 DEG C of incubators and beat
Rice machine decortication, is made Testa sojae atricolor and black soya bean fruit stores for future use；
S2：It is 50% that appropriate Testa sojae atricolor, which is weighed, in concentration of alcohol, and Extracting temperature is 60 DEG C, solid-liquid ratio 1：20, extraction time
For extraction centrifugation under the conditions of 70min, filter, that constant volume obtains anthocyanidin filtrate is standby；
S3：Weigh appropriate black soya bean fruit and the black soya bean dregs of rice are obtained to black soya bean progress degreasing from n-hexane；
S4：Press the black soya bean dregs of rice：Methanol=1：3-5 proportional arrangement is simultaneously warming up to 70 DEG C or so digestion 1.5-2 hours, then discharge opeing
Dilute cream is obtained with outer circulation concentrating and separating methanol；
S5：Dilute cream is adsorbed by adsorbent, decoction is extracted with 2-3 times of ethanol of the material after absorption, through dense
Stiff paste is obtained after contracting separating alcohol；
S6：Stiff paste is dried content be 20-30% isoflavones crude product；
S7：To isoflavones crude product ethanol extracting and refining, then it is more than 40% to be concentrated in vacuo, dry up to content
Isoflavones fine work, and pulverize and sieve isoflavones powder is standby；
S8：Money willow buddings 6-20min is cleaned using the saline solution of 1.5% concentration, 60-80 DEG C of temperature in use is pure after chopping
Water purification soaks 2-3 hours, is subsequently heated to 100 DEG C of decoction 1-2 hours, by cotton filter filter 23-5 times, produces money willow
Bud water extract；
S9：By the money willow buddings water extract in the isoflavones powder and S8 in the anthocyanidin filtrate and S7 in S2 press than
Example is blended together as active constituents of medicine, and is made after being mixed with pharmaceutically acceptable carrier with galenic pharmacy routine techniques
Agent.
Preferably, anthocyanidin filtrate in the S9：Isoflavones powder：Money willow buddings water extract presses 3：4：3 ratio is matched somebody with somebody
Than.
Preferably, the preparation that prepared by methods described is shaped as particle, aqueous solvent, capsule or pill.
Compared with prior art, the beneficial effects of the invention are as follows：
The pure food formulation formula and method of this treatment cardiovascular and cerebrovascular, using black soya bean, money willow buddings extract as raw material, will eat
Product preparation is made for particle, aqueous solvent, capsule or pill, can be fabricated to different preparations as needed, actually use
In, each food materials of the invention are cheap, can be long-term use of.
Embodiment
The embodiment of the present invention is will be detailed below, however, the embodiment of the present invention is not limited thereto.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made,
Belong to the scope of protection of the invention.
In the embodiment of the present invention：Black soya bean has the good reputation of " king in beans " of anti-aging, price material benefit, often eats with except having
Its cosmetic values, also medical value；The traditional Chinese medical science thinks, black soya bean flat property and sweet taste, returns kidney channel, the spleen channel, is that diet is recuperated good merchantable brand；Black soya bean
Rich in nutrition content, protein content are up to 49.8%, there is daizeol, soyasapogenol, protein, and containing B family vitamin,
High-quality aliphatic acid, carrotene, folic acid, folinic acid, copper, cobalt, iron ore prime element, vitamin B1 etc.；The traditional Chinese medical science thinks black category water,
Water walks kidney, and black soya bean can be advantageous to kidney tonifying as black food and support kidney, and the main essence and blood of the kidney of people, kidney are nourished, body
Qi and blood also can be sufficient, and kidney tonifying can be helped by often eating black soya bean, alleviate kidney deficiency and bodily weakness, soreness and weakness of waist and knees, Bi condition, articular instability etc.
Malaise symptoms；Saponin contained by black soya bean is reduced the effect of internal cholesterol, can effectively prevent middle-aged and old atherosclerosis
And angiocardiopathy；The traditional Chinese medical science thinks that black soya bean, which has, to be removed in pathogenic heat in the stomach numbness, wound, drenches leakage, lower extravasated blood, dissipate five accumulation of yin cold in viscera product, go to swell, disappear
Paddy, only abdominal distension, go heat toxin, improve the curative effects such as spasm.
Traditional Chinese Medicine experts point out that willow whole body is precious；Modern science proves that willow bark can cure cold, Flos Salicis Babylonicae can control haematemesis,
Spitting of blood etc., willow can stop blooding treat numbness control malignant sore, in recent years it has also been found that, withy can prevent and treat acute infectious hepatitis, Chronic Airway
Inflammation, angina pectoris, coronary heart disease and burn and scald etc..China medicine scholar knows very early obtains abundant medicinal material, Liu Zhi from willow
Root, skin, branch, leaf can be used as medicine, and have eliminating the phlegm improving eyesight, clearing heat and detoxicating, the windproof effect of diuresis, can Yellow River harnessing subcutaneous ulcer, cough as willow grinds juice
Blood, spit blood, have blood in stool, blood strangury and women's Amenorrhea, external application can control toothache, and willow leaf has diuresis, anti-inflammatory, removing toxic substances to make containing abundant tannin
With.In recent years, parenteral solution is made with willow leaf in the world of medicine, to the treatment infection of the upper respiratory tract, tracheitis, pneumonia, cystitis, suppurative
Parotitis, mastitis, sphagitis have good effect, and willow leaf also contains very high iodine, the sugar coated tablet made of it, can prevent and treat
Endemicgoiter is big.
Willow buddings are edible, can make tea, and can also cure the disease, but to be plucked before wadding of not blooming, when making tea, to select firm
The tender shoots of eruption is dried, and then reinstating boiling water with tealeaves one brews, the tea soaked with willow buddings and tealeaves, the delicate fragrance of sight, drink can
Mouthful, its benefit can the swollen disease of anti-Yellow River harnessing and arthralgia and myalgia disease.
Based on above-mentioned principle, there is provided a kind of pure food formulation formula for treating cardiovascular and cerebrovascular, including 90% main material and
10% auxiliary material, the raw material that main material is matched by following parts by weight form：Semen sojae atricolor extract 50-70 parts, money willow buddings carry
Take thing 30-50 parts；The raw material that auxiliary material is matched by following parts by weight forms：60 parts of ethanol, 10 parts of n-hexane, 10 parts of methanol,
5 parts of saline solution, surplus are pure water；Wherein, Semen sojae atricolor extract includes anthocyanidin, isoflavones, soap alcohol, protein, fat, dimension life
Element and trace element；Money willow buddings extract be mainly money willow buddings it is modulated, filtering after willow buddings water.
Embodiment one：
Take main material：50 parts of Semen sojae atricolor extract, 50 parts of money willow buddings extract；Auxiliary material：60 parts of ethanol, n-hexane 10
Part, 10 parts of methanol, 5 parts of saline solution, surplus are pure water.
Matched based on above-mentioned raw materials, there is provided a kind of method for the pure food formulation for treating cardiovascular and cerebrovascular, comprise the following steps：
The first step：Long 6-12mm, diameter 5-9mm, surface black or grey black are selected by above-mentioned parts by weight, it is smooth or have
Wrinkle, has gloss, there is the black soya bean of yellowish white oblong hilum side, rinsed with clear water, and dries and use in 30 DEG C of incubators
Thresher is peeled, and Testa sojae atricolor is made and black soya bean fruit stores for future use；
Second step：It is 50% that appropriate Testa sojae atricolor, which is weighed, in concentration of alcohol, and Extracting temperature is 60 DEG C, solid-liquid ratio 1：20, extraction
It is standby that extraction is centrifuged, filtered under the conditions of time is 70min, constant volume obtains anthocyanidin filtrate；
3rd step：Weigh appropriate black soya bean fruit and the black soya bean dregs of rice are obtained to black soya bean progress degreasing from n-hexane；
4th step：Press the black soya bean dregs of rice：Methanol=1：3-5 proportional arrangement is simultaneously warming up to 70 DEG C or so digestion 1.5-2 hours, then
Discharge opeing and outer circulation concentrating and separating methanol obtain dilute cream；
5th step：Dilute cream is adsorbed by adsorbent, decoction is extracted with 2-3 times of ethanol of the material after absorption,
Stiff paste is obtained after concentrated separating alcohol；
6th step：Stiff paste is dried content be 20-30% isoflavones crude product；
7th step：To isoflavones crude product ethanol extracting and refining, then be concentrated in vacuo, dry up to content be 40% with
On isoflavones fine work, and pulverize and sieve isoflavones powder is standby；
8th step：Money willow buddings 6-20min, 60-80 DEG C of temperature in use after chopping are cleaned using the saline solution of 1.5% concentration
Pure water immersion 2-3 hours, be subsequently heated to 100 DEG C of decoction 1-2 hours, by cotton filter filter 23-5 times, produce gold
Money willow buddings water extract；
9th step：By the isoflavones powder in the anthocyanidin filtrate and step 7 in step 2 and the money in step 8
Willow buddings water extract presses 3：4：3 proportions are blended together as active constituents of medicine, and with pharmaceutically acceptable carrier
Preparation is made with galenic pharmacy routine techniques after mixing, preparation shape is needed for particle, aqueous solvent, capsule or ball according to use
Agent.
Embodiment two：
Take main material：70 parts of Semen sojae atricolor extract, 30 parts of money willow buddings extract；Auxiliary material：60 parts of ethanol, n-hexane 10
Part, 10 parts of methanol, 5 parts of saline solution, surplus are pure water.
Based on above-mentioned raw materials match, there is provided a kind of method for the pure food formulation for treating cardiovascular and cerebrovascular, its preparation process with
Embodiment one is identical, does not illustrate herein.
Embodiment three：
Take main material：60 parts of Semen sojae atricolor extract, 40 parts of money willow buddings extract；Auxiliary material：60 parts of ethanol, n-hexane 10
Part, 10 parts of methanol, 5 parts of saline solution, surplus are pure water.
Based on above-mentioned raw materials match, there is provided a kind of method for the pure food formulation for treating cardiovascular and cerebrovascular, its preparation process with
Embodiment one, two is identical, does not illustrate herein.
Comparative example one, two, three：Successively in Example one, two, three obtained preparation to cardiovascular and cerebrovascular disease
Experimental subjects monitored in real time, after by 2-3 course for the treatment of, take the preparation of the recipe configuration of embodiment three to patient's
Improvement is apparently higher than the patient in embodiment one, two, therefore embodiment three is matched somebody with somebody as the optimal for the treatment of cardiovascular and cerebrovascular disease
Side and method should give large-scale popularization.
In summary：The pure food formulation formula and method of this treatment cardiovascular and cerebrovascular, using black soya bean, money willow buddings extract as
Raw material, food formulation is made for particle, aqueous solvent, capsule or pill, different preparations can be fabricated to as needed,
In actual use, each food materials of the invention are cheap, can be long-term use of.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (9)
- A kind of 1. pure food formulation formula for treating cardiovascular and cerebrovascular, it is characterised in that including 90% main material and 10% it is auxiliary Raw material, the raw material that main material is matched by following parts by weight form：Semen sojae atricolor extract 50-70 parts, money willow buddings extract 30-50 Part；The raw material that auxiliary material is matched by following parts by weight forms：60 parts of ethanol, 10 parts of n-hexane, 10 parts of methanol, 5 parts of saline solution, Surplus is pure water.
- A kind of 2. pure food formulation formula for treating cardiovascular and cerebrovascular according to claim 1, it is characterised in that the black soya bean Extract includes anthocyanidin, isoflavones, soap alcohol, protein, fat, vitamin and trace element.
- A kind of 3. pure food formulation formula for treating cardiovascular and cerebrovascular according to claim 1, it is characterised in that the money Willow buddings extract be mainly money willow buddings it is modulated, filtering after willow buddings water.
- 4. a kind of pure food formulation formula for treating cardiovascular and cerebrovascular according to claim 1, it is characterised in that including main original Material：50 parts of Semen sojae atricolor extract, 50 parts of money willow buddings extract；Auxiliary material：60 parts of ethanol, 10 parts of n-hexane, 10 parts of methanol, salt 5 parts of water, surplus are pure water.
- 5. a kind of pure food formulation formula for treating cardiovascular and cerebrovascular according to claim 1, it is characterised in that including main original Material：70 parts of Semen sojae atricolor extract, 30 parts of money willow buddings extract；Auxiliary material：60 parts of ethanol, 10 parts of n-hexane, 10 parts of methanol, salt 5 parts of water, surplus are pure water.
- 6. a kind of pure food formulation formula for treating cardiovascular and cerebrovascular according to claim 1, it is characterised in that including main original Material：60 parts of Semen sojae atricolor extract, 40 parts of money willow buddings extract；Auxiliary material：60 parts of ethanol, 10 parts of n-hexane, 10 parts of methanol, salt 5 parts of water, surplus are pure water.
- 7. it is a kind of it is according to claim 1 treatment cardiovascular and cerebrovascular pure food formulation method, it is characterised in that including with Lower step：S1：Long 6-12mm, diameter 5-9mm, surface black or grey black are selected by above-mentioned parts by weight, it is smooth or have wrinkle, have There is the black soya bean of yellowish white oblong hilum gloss, side, rinsed with clear water, and drying is taken off with thresher in 30 DEG C of incubators Skin, is made Testa sojae atricolor and black soya bean fruit stores for future use；S2：It is 50% that appropriate Testa sojae atricolor, which is weighed, in concentration of alcohol, and Extracting temperature is 60 DEG C, solid-liquid ratio 1：20, extraction time is It is standby that extraction is centrifuged, filtered under the conditions of 70min, constant volume obtains anthocyanidin filtrate；S3：Weigh appropriate black soya bean fruit and the black soya bean dregs of rice are obtained to black soya bean progress degreasing from n-hexane；S4：Press the black soya bean dregs of rice：Methanol=1：3-5 proportional arrangement is simultaneously warming up to 70 DEG C or so digestion 1.5-2 hours, then discharge opeing and outer Circulate concentrating and separating methanol and obtain dilute cream；S5：Dilute cream is adsorbed by adsorbent, decoction is extracted with 2-3 times of ethanol of the material after absorption, concentrated point From after ethanol stiff paste；S6：Stiff paste is dried content be 20-30% isoflavones crude product；S7：To isoflavones crude product ethanol extracting and refining, then it is concentrated in vacuo, dries up to the different Huang that content is more than 40% Ketone fine work, and pulverize and sieve isoflavones powder is standby；S8：Money willow buddings 6-20min, the pure water of 60-80 DEG C of temperature in use after chopping are cleaned using the saline solution of 1.5% concentration 2-3 hours are soaked, is subsequently heated to 100 DEG C of decoction 1-2 hours, by cotton filter filter 23-5 times, produces money willow buddings water Extract；S9：Money willow buddings water extract in isoflavones powder and S8 in anthocyanidin filtrate and S7 in S2 is mixed in proportion Preparation is made with galenic pharmacy routine techniques included together as active constituents of medicine, and after being mixed with pharmaceutically acceptable carrier.
- A kind of 8. method of pure food formulation for treating cardiovascular and cerebrovascular according to claim 7, it is characterised in that the S9 Middle anthocyanidin filtrate：Isoflavones powder：Money willow buddings water extract presses 3：4：3 proportions.
- A kind of 9. method of pure food formulation for treating cardiovascular and cerebrovascular according to claim 7, it is characterised in that the side Preparation prepared by method is shaped as particle, aqueous solvent, capsule or pill.
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| CN102946893A (en) * | 2010-06-18 | 2013-02-27 | 株式会社爱茉莉太平洋 | Composition containing colored bean extract |
| CN104585417A (en) * | 2014-12-24 | 2015-05-06 | 遂昌县维尔康青钱柳中草药专业合作社 | Cyclocarya paliurus beverage and preparation process thereof |
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| CN1102331A (en) * | 1993-11-04 | 1995-05-10 | 梁欣 | Method for extracting ginkgo extract from ginkgo leaf |
| CN102946893A (en) * | 2010-06-18 | 2013-02-27 | 株式会社爱茉莉太平洋 | Composition containing colored bean extract |
| CN102942550A (en) * | 2012-12-04 | 2013-02-27 | 江苏久吾高科技股份有限公司 | Method for extracting cyanidin from black bean peel |
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