CN107456269B - A kind of cryoablation conduit - Google Patents
A kind of cryoablation conduit Download PDFInfo
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- CN107456269B CN107456269B CN201710789762.8A CN201710789762A CN107456269B CN 107456269 B CN107456269 B CN 107456269B CN 201710789762 A CN201710789762 A CN 201710789762A CN 107456269 B CN107456269 B CN 107456269B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
- A61B2018/0022—Balloons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00505—Urinary tract
- A61B2018/00511—Kidney
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00589—Coagulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00714—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
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Abstract
The present invention relates to a kind of cryoablation conduits, including supply unit and freezing unit, the supply unit includes sheath and axially disposed circulation loop in the sheath, the freezing unit is arranged on the distal portions of the sheath, the freezing unit includes sacculus and directional curvature part, the distal portions of the circulation loop are arranged in the sacculus, the distal end of the circulation loop is fixedly connected with the distal end of the sacculus, the directional curvature part is socketed on the distal portions of the circulation loop, the change in shape of the sacculus drives the directional curvature part bending, so that the spacing-controllable of the circulation loop and the sacculus inner wall；It is avoided that sacculus inner direct refrigerant, effectively controls the rate of temperature fall and cryogenic temperature in cryoablation region, improve the freezing performance of cryoablation conduit.
Description
Technical field
The invention belongs to cryoablation fields, and in particular to a kind of cryoablation conduit.
Background technique
With China's life-time dilatation per capita, senile hypertension illness rate up to 40%~60%, although at present safely, have
The drug of effect is more and more, but the current treatment status of hypertension is still poor." the Chinese cardiovascular disease report announced according to 2006
2005 " statistics indicate that, at present China's Hypertensive Population awareness, treatment rate and control rate respectively be only 30.6%, 24.7%,
6.1%, hypertension prevention and control work in China's is also in reduced levels, therefore the timely and effective treatment of hypertension is that a whole society needs
The problem of paying close attention to jointly.According to 2003 the 7th time U.S.'s prevention, detection, assessment and the treatment hypertension Joint National committee report
It accuses (JNC7), there is hypertensive patient 1,000,000,000 or so in the current whole world, more in rising trend in recent years.Especially for the high blood of intractable
The treatment of pressure is especially urgent, and resistant hypertension, which refers to, takes the antihypertensive drugs (including diuretics) of three kinds or more simultaneously
Also life style is changed, but blood pressure is still greater than or the hypertension equal to 140/90mmHg.Resistant hypertension is person in middle and old age
The most common cardiovascular disease of people is to lead to coronary heart disease, cerebral apoplexy, congestive heart failure, renal failure, aortic aneurysm etc.
The first cause that important risk factor and the middle-aged and the old are lethal, disable.
Research shows that: renal sympathetic nerve discharge (renal sympathetic nerve activity, RSNA) will lead to
Renal tubule sodium fluid reabsorption increases, renin release and renal vascular resistance is caused to change, so that blood pressure be made to increase.And it is handed over by kidney
Feel afferent nerve and adjusts blood pressure by the reflection signal transduction of kidney receptor to maincenter, then by renal sympathetic efferent nerve.
RSNA can not only adjust the variation of arteria renalis antiotasis, and long-term an important factor for maintaining hypertension in short term.Therefore, using kidney
Artery cryoablation conduit carries out the ablation of arteria renalis sympathetic nerve, is a kind of to treat high blood for obstinate hypertension
The new hope of pressure, while being also a new method of non-drug therapy hypertension, this is shown according to the clinical test of external early period
Method is safe and effective and can be widely used, and hypertensive patient can also be made to get rid of the puzzlement taken drugs daily.
Chinese patent CN201520045658 has the cryoablation foley's tube of guidewire lumen, the basic principle is that passing through ball
It is encapsulated the stifled arteria renalis, blocking blood flow, then by the helical structure released cold quantity of intermediate region in sacculus, to reach to the arteria renalis
It is melted, although the conduit can carry out cryoablation to the arteria renalis, needs to block the arteria renalis and blocking blood flow to improve
The freezing performance of conduit, there is a possibility that kidney causes ischemic necrosis if blocking time is too long.
Mostly in existing cryoablation product is outside centered on cold source in sacculus inner direct refrigerant or sacculus
The structure of diffusion, but this structure of sacculus inner direct refrigerant is easy to make sacculus explosion, danger coefficient is too high；And sacculus
Interior too slow to the structure rate of temperature fall of external diffusion centered on cold source, cooling capacity consumption is too big.
Summary of the invention
In view of the drawbacks described above of the prior art, technical problem to be solved by the invention is to provide a kind of cryoablations to lead
Pipe, this cryoablation conduit avoid refrigerant and inject directly in sacculus, but by built in balloon features variation drive
There is the circulation line of directional curvature part to be bent, so that spacing of the circulation loop apart from sacculus inner wall is adjustable.
The technical solution adopted by the present invention to solve the technical problems is:
A kind of cryoablation conduit, including supply unit and freezing unit, the supply unit include sheath and described
Axially disposed circulation loop in sheath, the freezing unit are arranged on the distal portions of the sheath, and the freezing is single
Member includes sacculus and directional curvature part, and the distal portions of the circulation loop are arranged in the sacculus, the circulation loop
Distal end be fixedly connected with the distal end of the sacculus, the directional curvature part is socketed in the distal portions of the circulation loop
On, the change in shape of the sacculus drives the directional curvature part bending, so that the circulation loop and the sacculus inner wall
Spacing-controllable.
The present invention solves further technical solution used by its technical problem:
In one embodiment, the directional curvature part is the stainless steel tube or NiTi pipe of unilateral joint-cutting, the unilateral side
Joint-cutting is arranged on the side towards the sacculus geometric center.
In one embodiment, the directional curvature part is spring ring, and the middle section of the spring ring is described in
Sacculus geometric center side is fixed on the circulation loop.
In one embodiment, it is provided in the distal end of the directional curvature part and/or proximal end and adjusts curved bolster.
In one embodiment, the curved bolster is spring or macromolecule hose.
In one embodiment, the circulation loop includes multiple groups input pipe and efferent duct, input pipe described in every group and
The distal end of the efferent duct connects, and forms a n shape circuit, the interlaced setting in distal end in multiple n shape circuits.
In one embodiment, the circulation loop includes input pipe and efferent duct, and the distal end of the circulation loop is set
Multi-channel pipe is set, the multi-channel pipe is fixedly connected with the distal end of the sacculus, and the input pipe is defeated with the multi-channel pipe
The delivery outlet of inlet seal, the efferent duct and the multi-channel pipe seals.
In one embodiment, the circulation loop includes input pipe and efferent duct, and the distal end of the circulation loop is set
Cooling capacity exchanging element is set, the distal end of the Cooling capacity exchanging element is blocked, distal end and the sacculus of the Cooling capacity exchanging element
Distal end be fixedly connected, the proximal end of the Cooling capacity exchanging element distal seal with the input pipe and the efferent duct respectively.
In one embodiment, the supply unit further includes liquid injection pipe, and the proximal end of the liquid injection pipe and topping-up pump connect
Logical, the distal end of the liquid injection pipe is in fluid communication with the sacculus, and the heat-conducting medium in the topping-up pump passes through the liquid injection pipe quilt
It is injected into the sacculus.
In one embodiment, the amount of the heat-conducting medium injected in the sacculus limits the shape of the sacculus.
Compared with the existing technology, advantages of the present invention and progress are as follows:
1, cryoablation conduit of the invention passes through directional curvature part list by the way that directional curvature part is arranged on circulation loop
The design that positions in the middle part of lateral incision seam or spring ring adjusts sacculus by topping-up pump so that the bending direction of directional curvature part is controllable
Interior pressure changes the shape of sacculus, so that shape corresponding change of the bending angle of directional curvature part with sacculus, pressure
The angle of more macrobending is bigger, and directional curvature part is closer apart from sacculus inner wall, and then drives the synchronous bending of circulation loop, so that following
Loop back path and the spacing of sacculus inner wall be it is adjustable, the smaller freezing performance of spacing of circulation loop and sacculus inner wall is better, because
The rate of temperature fall and cryogenic temperature in cryoablation region can be effectively controlled in this, improves the freezing performance of conduit.
2, cryoablation conduit of the invention adjusts curved bolster by the setting at directional curvature part both ends, can be to avoid orientation
Bool improves safety with the operation risk caused by the damage of knee when ball intraluminal pressure macrobending amplitude increases.
3, cryoablation conduit of the invention can be effective by multiple groups cross arrangement by setting multiple groups circulation loop
Ground improves the freezing performance of conduit, so that cooling capacity dispersion is more evenly；The distal end switching multi-channel pipe of circulation loop, each access interlock
It communicates, so that freezing performance is more balanced；Cooling capacity exchanging element is arranged in the distal end of circulation loop, and cooling capacity aggregation can be controlled preferably
The dispersion of refrigerating capacity, optimization freezing performance.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of cryoablation conduit of the invention；
Fig. 2 a is the structural schematic diagram of the first freezing unit of cryoablation conduit of the invention；
Fig. 2 b is the using process diagram of the freezing unit of Fig. 2 a；
Fig. 3 is the structural schematic diagram of second of freezing unit of cryoablation conduit of the invention；
Fig. 4 a is diagrammatic cross-section of the supply unit along A-A of cryoablation conduit shown in FIG. 1 of the invention；
Fig. 4 b is the freezing unit of cryoablation conduit of the invention and its diagrammatic cross-section along B-B；
Fig. 5 a is the structural schematic diagram of the distal end of the first circulation loop of cryoablation conduit of the invention；
Fig. 5 b is the structural schematic diagram of the distal end of second of circulation loop of cryoablation conduit of the invention；
Fig. 5 c is the structural schematic diagram of the distal end of the third circulation loop of cryoablation conduit of the invention；
Wherein, 110 be freezing unit, and 120 be supply unit, and 130 be operating unit, and 111 be sacculus, and 1121 be directing curves
Bent part, 11211 be the stainless steel tube or NiTi pipe of unilateral joint-cutting, and 11212 be spring ring, and 1122 be to adjust curved bolster, and 11221 are
First adjusts curved bolster, and 11222 be the curved bolster of the second tune, and 1123 be Cooling capacity exchanging element, and 1124 be multi-channel pipe, and 121 are
Sheath, 122 be circulation loop, and 123 be wire leading pipe, and 124 be liquid injection pipe, and 1221 be input pipe, and 1222 be efferent duct, and 131 be control
Handle processed, 132 be freezing handle, and 1311 be operation handle, and 1312 be wire leading pipe attachment base, and 1313 be liquid injection pipe attachment base,
1321 be connection hose, and 1322 be inlet suction port, and 1323 be vacuum adapter, and 1324 be return-air connector.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, as follows in conjunction with drawings and embodiments
The present invention is described in detail.
Proximal end of the present invention refers to that one end close to operator, the distal end refer to far from operator
One end.
Shown in b as Figures 1 and 4, a kind of cryoablation conduit of the invention includes freezing unit 110, supply unit 120, behaviour
Make unit 130, the supply unit 120 includes sheath 121 and axially disposed circulation loop 122 in the sheath 121,
The circulation loop 122 includes input pipe 1221 and efferent duct 1222, and the freezing unit 110 is arranged on the sheath 121
Distal portions, the freezing unit 110 include sacculus 111 and directional curvature part 1121, the distal portions of the circulation loop 122
It is arranged in the sacculus 111, the distal end of the circulation loop 122 is fixedly connected with the distal end of the sacculus 111, described fixed
It is socketed in bool 1121 on the distal portions of the circulation loop 122, described in the change in shape drive of the sacculus 111
Directional curvature part 1121 is bent, so that the spacing-controllable of the circulation loop 122 and 111 inner wall of sacculus.
Wherein input pipe 1221 flows back for conveying refrigerant, efferent duct 1222 for refrigerant, and input pipe 1221 conveys
Refrigerant is flowed back by efferent duct 1222 again to sacculus 111, establishes a circulation path, and refrigerant passes through input pipe 1221 and output
To which cooling capacity is transmitted to therapentic part, refrigerant does not spray directly for heat-conducting medium heat exchange in pipe 1222 and sacculus 111
In sacculus inner wall, the safety of cryoablation conduit is improved.
Shown in a as Figures 1 and 4, supply unit 120 includes wire leading pipe 123, liquid injection pipe 124, circulation loop 122 and sheath
121, wherein wire leading pipe 123, liquid injection pipe 124, circulation loop 122 are respectively set in sheath 121,121 distal end of sheath and ball
111 proximal end hot-melting sealed of capsule, 121 inner cavity of sheath generate vacuum by equipment, form vacuum heat-insulating layer；The distal end of wire leading pipe 123
With the distal end hot-melting sealed of sacculus 111,1312 dispensing of wire leading pipe attachment base on the proximal control handle 131 of wire leading pipe 123 is close
Envelope, wire leading pipe 123 is seal wire access, for assisting cryoablation conduit to establish channel in vivo；The distal end of liquid injection pipe 124 and ball
The proximal end hot-melting sealed of capsule 111, and be in fluid communication with the sacculus 111, the proximal end of the liquid injection pipe 124 is connected to topping-up pump,
Heat-conducting medium in the topping-up pump is injected into the sacculus 111 by the liquid injection pipe 124, keeps sacculus 111 full, note
The amount for entering the heat-conducting medium in the sacculus 111 limits the shape of the sacculus 111, the proximal end of liquid injection pipe 124 and control
1313 dispensing of liquid injection pipe attachment base sealing on handle 131.
Operating unit 130 includes freezing handle 132 and control handle 131, and freezing handle 132 includes connection 1321 He of hose
Inlet suction port 1322, return-air connector 1324 and the vacuum adapter 1323 of freezing 132 proximal end of handle, circulation loop are set
122 are arranged in the connection hose 1321, and are connect by inlet suction port 1322 with freezing equipment, for receiving refrigeration
Agent.Connect hose 1321 distal end by control handle 131 and sheath 121 be in fluid communication, and with control handle 131 and freeze hand
132 dispensing of handle sealing makes the inner cavity of hose 1321 and sheath 121 generate vacuum, forms vacuum heat-insulating layer, use will pass through equipment
Optimize the performance of cryoablation conduit in protection circulation loop 122.
Seal wire is arranged in wire leading pipe 123, and cryoablation conduit is moved to destination organization ablation areas along seal wire.Note
Liquid pump is connected to the liquid injection pipe attachment base 1313 on control handle 131, passes through 124 filling heat-conductive medium Filled Balloon of liquid injection pipe
111, topping-up pump, which is adjusted to suitable pressure, can make 111 dilatancy of sacculus, and directional curvature part 1121 is driven to be bent, so that fixed
It drives circulation loop 122 to be bonded 111 inner wall of sacculus to bool 1121,1121 distance of directional curvature part can control by pressure regulation
The spacing of 111 inner wall of sacculus, therefore the rate of temperature fall and cryogenic temperature of cryoablation conduit can be efficiently controlled；Starting device
Freezing function, refrigerant are inputted by equipment storage device, inlet suction port 1322 and circulation loop 122 on chilled handle 132
It is transported in sacculus 111, as shown in Figure 5 a, circulation loop 122 includes multiple groups input pipe 1221 and efferent duct 1222, and every group defeated
Enter pipe 1221 to connect with the distal end of efferent duct 1222, be arranged to a n shape circuit, the distal end in multiple n shape circuits is mutually handed over
Mistake setting.Refrigerant is directly flowed back by efferent duct 1222 after reaching 1221 distal end of input pipe, is reached using supply unit 120 cold
Freeze handle 132, refrigerant storage device is flowed by return-air connector 1324, thus generates refrigerating cycle.Due to having in sacculus 111
Injection, the distal portions of circulation loop 122 generate cooling capacity by liquid conductive under ultralow temperature, and sacculus 111 is made to form ice hockey,
Make its internal generation ice crystal and tearing phenomenon through tissue, to achieve the purpose that cryoablation.After being chilled to the predetermined time,
Pass hull closure freezes button, opens rewarming function, and rewarming is the room temperature that equipment will enter cryoablation conduit by heating device
Gas is heated to scheduled temperature, so that the gas into input pipe 1221 be made to become hot gas, reaches the distal end of circulation loop 122
It can accelerate the dissolution of ice hockey that sacculus 111 is made to be rapidly separated tissue behind part, avoid causing due to 111 long-time blocking blood flow of sacculus
Damage.After reaching the rewarming predetermined time, rewarming button is closed, pumpback topping-up pump shrinks sacculus 111, while cryoablation being led
Pipe is recalled intrathecal, makes freezing unit 110 become lineament by the constraint and resistance of sheath external to recalling, completes entire cold
Freeze ablation procedure.
As shown in Figure 5 b, the circulation loop 122 includes multiple groups input pipe 1221 and efferent duct 1222, circulation loop 122
Distal end multi-channel pipe 1124 is set, the multi-channel pipe 1124 is fixedly connected with the distal end of the sacculus 111, every group of input pipe
1221 weld close with the input port welded seal of multi-channel pipe 1124, the delivery outlet of every group of efferent duct 1222 and multi-channel pipe 1124
Envelope, the stabilized structure that multiple groups input pipe 1221 and efferent duct 1222 are combined, cooling capacity is uniformly dispersed when freezing, and performance is more stable.
As shown in Figure 5 c, Cooling capacity exchanging element 1123 is arranged in the distal end of circulation loop 122, and the distal end of Cooling capacity exchanging element 1123 is sealed
Stifled, the distal end of the Cooling capacity exchanging element 1123 is fixedly connected with the distal end of the sacculus 111, Cooling capacity exchanging element 1123 it is close
The distal end welded seal with the input pipe 1221 of the circulation loop 122 and efferent duct 1222 respectively is held, refrigerant is through input pipe
After 1221 reach Cooling capacity exchanging element 1123, release is sprayed in Cooling capacity exchanging element 1123, then flow out by efferent duct 1222
To refrigerant storage device, refrigerating cycle is completed, this structure cooling capacity is more assembled, and performance is uniform, and effect is more preferable.
In one embodiment, as shown in figures 2 a and 2b, directional curvature part 1121 be unilateral joint-cutting stainless steel tube or
NiTi pipe 11211, unilateral joint-cutting are arranged on the side towards 111 geometric center of sacculus, built in directional curvature part 1121
Input pipe 1221 or efferent duct 1222, in order to not influence cooling capacity conduction, material is preferably metal.Because of directional curvature part 1121
Both ends are separately fixed at sacculus 111 proximally and distally, during 111 dilatancy of sacculus, 1121 stress of directional curvature part
It is squeezed and deformed, it is fixed since the joint-cutting direction of directional curvature part 1121 is directed towards the side of 111 geometric center of sacculus
It is that the direction expanded towards sacculus 111 is bent to bool 1121, it is fixed when deformation increases when sacculus 111 because internal pressure becomes larger
Also become larger therewith to 1121 stress of bool, the bending angle of directional curvature part 1121 also becomes larger simultaneously；When pressure reaches properly
Directional curvature part 1121 can be bonded 111 inner wall of sacculus when value.When sacculus 111 is shunk, with the reduction of pressure and ball in sacculus 111
The external constraint of capsule 111, directional curvature part 1121 can opposite rebound, tend to lineament, when withdrawing cryoablation conduit into sheath
It is interior, in addition the restraining force of sheath can be such that freezing unit 110 becomes linearly, so that cryoablation conduit withdraws from external ratio smoothly.It is fixed
The size control adjusting curved function, and can deforming according to sacculus 111 can be realized according to 111 expansion or shrinkage of sacculus to bool 1121
The bending angle of directional curvature part 1121 is allowed to be bonded 111 inner wall of sacculus, so that the freezing performance of cryoablation conduit is more preferable.If
It prevents from causing unnecessary damage because cooling capacity release is excessive, it can be by the deformation extent of regulation sacculus 111, to change directing curves
The distance between bent part 1121 and 111 inner wall of sacculus, to control the rate of temperature fall and cryogenic temperature in cryoablation region.It is unilateral
The stainless steel tube or 11211 plasticity of NiTi pipe of joint-cutting are preferable, are easy to control, fixed simple, can preferably meet directing curves simultaneously
The bent bending of part 1121 and rebound function, facilitate cryoablation conduit to withdraw into sheath.
It is provided in the distal end of directional curvature part 1121 and/or proximal end and adjusts curved bolster 1122.In one embodiment,
It is the first curved bolster 11221 of tune that 1121 distal end of directional curvature part, which is arranged in, is arranged in the directional curvature part 1121
Proximal end is the second curved bolster 11222 of tune.First adjusts the proximal end of curved bolster 11221 and directional curvature part 1121 distally solid
Fixed, first adjusts the distal end of the distal end of curved bolster 11221 and input pipe 1221 or efferent duct 1222 to fix；Second adjusts curved bolster
11222 distal end is fixed with 1121 proximal end of directional curvature part, and second adjusts the proximal end of curved bolster 11222 and input pipe 1221 or defeated
Outlet pipe 1222 is fixed.The curved bolster 11221 of first tune and the second curved bolster 11222 of tune are spring or macromolecule hose.One
In a embodiment, first adjusts the distal end clearance fit of the proximal end of curved bolster 11221 and directional curvature part 1121, boundary gap
Place uses UV glue or the fixed protection of high molecular material；Second adjusts the distal end of curved bolster 11222 and directional curvature part 1121
Proximal end clearance fit uses UV glue or the fixed protection of high molecular material at the gap of boundary；When sacculus 111 expands, directing curves
The bent meeting of part 1121 bending deformation, if the curved bolster 11221 of the first tune and the second curved bolster 11222 of tune are springs, due to spring
Elasticity and better softness, and the knee of directional curvature part 1121 is set, can be bent in directional curvature part 1121
Strong buffering and protection are provided when bent and input pipe 1221 and efferent duct 1222 can be protected not to be lost；After sacculus 111 is shunk,
First adjusts curved bolster 11221 and second to adjust curved bolster 11222 that directional curvature part 1121 can be followed to change, and finally returns that initial
Lineament is withdrawn from vitro convenient for cryoablation conduit.
In another embodiment, as shown in figure 3, being with the difference of Fig. 2 a and 2b: directional curvature part 1121 is bullet
Spring coil 11212, the middle section of the spring ring 11212 is fixed on towards the 111 geometric center side of sacculus to be recycled back to
On the road, with fixed spring circle and bending direction is controlled, the loose opposite side of spring ring 11212 makes directional curvature convenient for bending
Part 1121 is bent towards the direction that sacculus 111 expands and is intended to 111 inner wall of sacculus；The elasticity and flexibility of spring ring 11212
Preferably, bending and rebound function can be realized well, when sacculus 111 is shunk, with the reduction of pressure and sacculus in sacculus 111
111 external constraint, freezing unit 110 tend to linearly, withdraw cryoablation conduit 100 into sheath to more smooth in vitro.
Finally it should be noted that the foregoing is merely preferred embodiment of the invention, it is not limited to this
Invention, any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in this hair
Within bright protection scope.
Claims (10)
1. a kind of cryoablation conduit, it is characterised in that: including supply unit (120) and freezing unit (110), the conveying is single
First (120) include sheath (121) and axially disposed circulation loop (122) in the sheath (121), the freezing unit
(110) distal portions of the sheath (121) are arranged on, the freezing unit (110) includes sacculus (111) and directional curvature
Part (1121), the distal portions of the circulation loop (122) are arranged in the sacculus (111), the circulation loop (122)
Distal end be fixedly connected with the distal end of the sacculus (111), the directional curvature part (1121) is socketed in the circulation loop
(122) on distal portions, the change in shape of the sacculus (111) drives directional curvature part (1121) bending, so that institute
State the spacing-controllable of circulation loop (122) Yu the sacculus (111) inner wall.
2. cryoablation conduit according to claim 1, which is characterized in that the directional curvature part (1121) is that unilateral side is cut
The stainless steel tube or NiTi pipe (11211) of seam, the unilateral side joint-cutting are arranged on one towards the sacculus (111) geometric center
Side.
3. cryoablation conduit according to claim 1, which is characterized in that the directional curvature part (1121) is spring ring
(11212), the middle section of the spring ring (11212) is fixed to described towards the sacculus (111) geometric center side
On circulation loop (122).
4. cryoablation conduit according to claim 1, which is characterized in that in the distal end of the directional curvature part (1121)
And/or proximal end is provided with and adjusts curved bolster (1122).
5. cryoablation conduit according to claim 4, which is characterized in that the curved bolster (1122) is spring or height
Molecule hose.
6. cryoablation conduit according to claim 1, which is characterized in that the circulation loop (122) includes that multiple groups are defeated
Enter pipe (1221) and efferent duct (1222), input pipe described in every group (1221) is connected with the distal end of the efferent duct (1222), shape
At a n shape circuit, the interlaced setting in distal end in multiple n shape circuits.
7. cryoablation conduit according to claim 1, which is characterized in that the circulation loop (122) includes input pipe
(1221) and multi-channel pipe (1124) are arranged in efferent duct (1222), the distal end of the circulation loop (122), the multi-channel pipe
(1124) it is fixedly connected with the distal end of the sacculus (111), the input pipe (1221) is defeated with the multi-channel pipe (1124)
Inlet seal, the delivery outlet sealing of the efferent duct (1222) and the multi-channel pipe (1124).
8. cryoablation conduit according to claim 1, which is characterized in that the circulation loop (122) includes input pipe
(1221) and Cooling capacity exchanging element (1123) are arranged in efferent duct (1222), the distal end of the circulation loop (122), and the cooling capacity is handed over
The distal end for changing element (1123) is blocked, and the distal end of the Cooling capacity exchanging element (1123) and the distal end of the sacculus (111) are solid
Fixed connection, the proximal end of the Cooling capacity exchanging element (1123) respectively with the input pipe (1221) and the efferent duct (1222)
Distal seal.
9. cryoablation conduit according to claim 1, which is characterized in that the supply unit (120) further includes fluid injection
It manages (124), the proximal end of the liquid injection pipe (124) is connected to topping-up pump, the distal end of the liquid injection pipe (124) and the sacculus
(111) it is in fluid communication, the heat-conducting medium in the topping-up pump is injected into the sacculus (111) by the liquid injection pipe (124)
It is interior.
10. cryoablation conduit according to claim 9, which is characterized in that injects in the sacculus (111) described leads
The amount of thermal medium limits the shape of the sacculus (111).
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109464186B (en) | 2017-09-08 | 2023-12-22 | 泽丹医疗股份有限公司 | Device and method for treating lung tumors |
| CN109674525B (en) * | 2018-12-21 | 2021-04-06 | 海杰亚（北京）医疗器械有限公司 | Treatment equipment for medical freezing sacculus |
| CN114404023A (en) * | 2019-09-03 | 2022-04-29 | 深圳北芯医疗科技有限公司 | Variable hardness structure, flexible seal wire and cryoablation device |
| CN111150482A (en) * | 2019-12-09 | 2020-05-15 | 戴海龙 | Freezing balloon catheter for treating clinical pulmonary arterial hypertension |
| CN113842205B (en) * | 2021-11-11 | 2023-05-26 | 上海导向医疗系统有限公司 | J-T groove position-adjustable cryoablation needle |
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| CN1494878A (en) * | 2002-09-23 | 2004-05-12 | 弘 李 | Ball catheter for non-continuously heating to remake tissue of human body |
| WO2017047545A1 (en) * | 2015-09-14 | 2017-03-23 | テルモ株式会社 | Ablation catheter |
| CN207870951U (en) * | 2017-09-05 | 2018-09-18 | 康沣生物科技(上海)有限公司 | A kind of cryoablation conduit |
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| US20090281532A1 (en) * | 2008-05-07 | 2009-11-12 | The General Hospital Corporation | Arrangement for use with a balloon ablation catheter |
| CN107847270B (en) * | 2015-08-03 | 2021-08-31 | 波士顿科学医学有限公司 | Steerable tissue mapping and ablation device |
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|---|---|---|---|---|
| CN1494878A (en) * | 2002-09-23 | 2004-05-12 | 弘 李 | Ball catheter for non-continuously heating to remake tissue of human body |
| WO2017047545A1 (en) * | 2015-09-14 | 2017-03-23 | テルモ株式会社 | Ablation catheter |
| CN207870951U (en) * | 2017-09-05 | 2018-09-18 | 康沣生物科技(上海)有限公司 | A kind of cryoablation conduit |
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