CN107455374A - A kind of rodents sterilant synergist and its application in muroid bait material is prepared - Google Patents
A kind of rodents sterilant synergist and its application in muroid bait material is prepared Download PDFInfo
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- CN107455374A CN107455374A CN201710580552.8A CN201710580552A CN107455374A CN 107455374 A CN107455374 A CN 107455374A CN 201710580552 A CN201710580552 A CN 201710580552A CN 107455374 A CN107455374 A CN 107455374A
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- Prior art keywords
- synergist
- apholate
- bait material
- rodents sterilant
- rodents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of rodents sterilant synergist, including dimethylformamide, Tween 80 and water, the volume ratio of the dimethylformamide, Tween 80 and water is 10~20:1~10:100~200.The apholate synergist that the present invention uses reduces 50% or so of rodents sterilant dosage, has saved cost and has reduced the Environmental Residues of medicine and reduce the danger to other non-target organisms.
Description
Technical field：
The invention belongs to rodents sterilant technical field, and in particular to a kind of rodents sterilant synergist and its prepare mouse
Application in class bait material.
Background technology：
From the end of the fifties in last century so far, there is the research of the largely physiological mechanism to insect sterile technique and sterile effect, and sieve
Select the apholate with application potential.But most of apholates are insoluble in water, occur when preparing pharmaceutical chemistry：Apholate
Permeability is poor, disperse attachment it is not uniform enough, it is larger using the dosage of medicine the problems such as, this not only causes the abuse and wave of medicine
Take, and influence the palatability of pharmaceutical chemistry, as Rattus losea is relatively low to the free food ration of the paddy pharmaceutical chemistry of two kinds of apholates, and
Feeding rapid decline in 1 to 3 day, the apholate rice pharmaceutical chemistry that Rattus nitidus is prepared to adhesion method, also shows same trend.It is domestic
Other outer scholars are also contemplated for that particle dress apholate bait is made after bait mixes with apholate pulvis with crushing, and can partly overcome not
The problem of agent is insoluble in water is educated, but is restricted in the application of warmed moist area.Southern area uses paddy more, prepares pharmaceutical chemistry
When, high amount of drug active ingredient is difficult to immerse in the grain of rice, so as to cause drug waste, and then reduces control effect.It is existing not
Agent is educated due to the factors such as technology and cost, practical application area very little, it is difficult to realize commercial application.
The content of the invention：
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of rodents sterilant synergist and its preparing
Application in muroid bait material.The apholate synergist that the present invention uses reduces 50% or so of rodents sterilant dosage,
Cost is saved and has reduced the Environmental Residues of medicine and reduce the danger to other non-target organisms.
First purpose of the present invention is to provide a kind of rodents sterilant synergist, including dimethylformamide, Tween-
80 and water, the volume ratio of the dimethylformamide, Tween-80 and water is 10~20:1~10:100~200.
Dimethylformamide is a kind of transparency liquid, can be dissolved each other with water and most of organic solvent.It is chemical reaction
Common solvent.Dimethylformamide is that have high boiling polarity (hydrophily) non-protonic solvent, molecular weight 73.10, relatively
Density 0.9445 (25 DEG C), -61 DEG C of fusing point, 152.8 DEG C of boiling point, 57.78 DEG C of flash-point.With water and usual immiscible organic solvent, with
Petroleum ether mixing layering.As analytical reagent and vinyl, the solvent of acetylene.Dimethylformamide is to a variety of high polymers as gathered
Ethene, polyvinyl chloride, polyacrylonitrile, polyamide etc. are good solvent.Dimethylformamide is both a kind of to have many uses
Excellent solvent, and the industrial chemicals that a kind of purposes is extremely wide.In petro chemical industry, dimethylformamide can be used as gas
Absorbent, for separating and processed gas.In organic reaction, dimethylformamide is not only widely used as the solvent of reaction,
It is the important intermediate of organic synthesis.It can be used to produce Spanon in pesticide industry；It can be used for synthesis iodine amine phonetic in medical industry
Pyridine, fortimicin, cortisone, vitamin B6, iodoxuridine, monopar, Pyrantel, N- N-foymylsarcolysins, chloramphenalan, methoxy virtue
Mustard, Bian mustargen, lomustine, florafur, tranxamic acid, times point U.S. pine, megestrol acetate, anethol trithione, chlorpheniramine etc..
Dimethylformamide has catalytic action in the reaction of hydrogenation, dehydrogenation, dehydration and dehydrohalogenation, reduces reaction temperature, production
Product purity improves.
Sorbitan monooleate APEO (Tween 80) abbreviation emulsifying agent T-80.By anhydrous sorbitol list oil
Acid esters forms with ethylene oxide polymerization.It is soluble in water, ethanol, vegetable oil, ethyl acetate, methanol, toluene insoluble are dissolved in mineral
Oil.Emulsifying agent, dispersant, wetting agent, solubilizer, stabilizer etc. are may be used as, for industry such as active compound, cosmetics, food；
Stabilizer, blowing promotor are used as in polyurethane foam plastics production；Antistatic additive can be used as in synthetic fibers, is preparation medium
Intermediate；It is used as wetting agent and dispersant in photosensitive material cinefilm；Nationality is to emulsify silicon during fabric waterproof
Oil, there is good effect, be also used for the component of continuous synthetic fibre and viscose glue curtain finish.It can be used as precision machine tool modulation metalworking coolant
Deng.Food industry is used as ice cream emulsifying agent, and dosage is 0.1% butter, dosage 1% or so in general oil.
The present invention uses dimethylformamide to coordinate pharmaceutically-active Tween-80 as a kind of main synergistic component, pass through
Quantitatively multi step strategy is crossed, realizes the preparation and application of synergist, program is simple, easily operated.
Second object of the present invention is to provide the preparation method of above-mentioned rodents sterilant synergist, comprises the following steps：
(1) Tween-80 of formula ratio is dissolved with water, 20~45 DEG C of water temperature；
(2) dimethylformamide is added into above-mentioned solution, rodents sterilant synergist is made to being completely dissolved in stirring.
Third object of the present invention is to provide a kind of muroid bait material, makees comprising above-mentioned rodents sterilant synergist
For active component.
Fourth object of the present invention is to provide application of the rodents sterilant synergist in muroid bait material is prepared, bag
Include following steps：
(1) add rodents sterilant into apholate synergist to be stirred until homogeneous, according to every 1000mL apholates synergist
5~100g of middle addition rodents sterilant, forms the sterile agent solution containing apholate synergist；
(2) bait material is added in the sterile agent solution containing apholate synergist in step (1) to stir, according to
Contain the bait material that 24.5~500kg is added in the sterile agent solution of apholate synergist per 1000mL, dry or dry, i.e.,
Muroid bait material that must be containing apholate synergist.
It is preferred that the rodents sterilant of described step (1) is fat-soluble apholate or water-soluble apholate.In the present invention
In, described rodents sterilant is preferably quinestrol, mifepristone or Cabergoline.
It is preferred that the bait material of the step (2) is selected from one or more of paddy, wheat and sorghum.
The present invention compared with prior art, has the following advantages that：
1. the present invention uses dimethylformamide to coordinate pharmaceutically-active Tween-80 as a kind of main synergistic component,
By quantitative multi step strategy, the preparation and application of synergist are realized, program is simple, easily operated.
2. the present invention has filled up the blank of existing rodents sterilant synergist practical application area.
3. reducing 50% or so of rodents sterilant dosage, cost is saved and has reduced Environmental Residues and the reduction of medicine
To the danger of other non-target organisms.
4. the index height of ingesting of bait material, significantly improves apholate control effect, reduces muroid breeding potential.
Embodiment：
Following examples are to further explanation of the invention, rather than limitation of the present invention.
Except special instruction, experiment material and reagent in the present invention are the art routine commercial products.
Embodiment 1：
Tween-80 100mL are measured, 20 DEG C of water 1000mL is added, stirs and evenly mixs, dimethylformamide 100mL is added, stirs
Mixing is mixed, obtains apholate synergist solution；Fresh paddy 500kg is weighed, adds the apholate synergist solution prepared
1000mL, according to the bait material that 500kg is added in every 1000mL apholates synergist solution, it is stirred until homogeneous, dries, be made
Synergist pharmaceutical chemistry.
The synergist paddy bait prepared is taken to feed small white mouse, compared with the blank paddy bait with being not added with synergist feeds small white mouse
Compared with sterile rate is as shown in table 1：
Table 1
As can be seen from Table 1, synergist paddy bait is used alone not impact small white mouse breeding, single apholate increases
Effect agent solution does not act on.
Embodiment 2：
Tween-80 100mL are measured, 20 DEG C of water 1000mL is added, stirs and evenly mixs, dimethylformamide 100mL is added, stirs
Mix mixing；The synergist solution 1000mL after mixing is weighed, quinestrol 100g is added, according in every 1000mL apholates synergist
100g rodents sterilant is added, stirring is to being completely dissolved.Fresh paddy 500kg is weighed, adds the synergy quinestrol prepared
Solution 1000mL, the bait material that 500kg is added in the sterile agent solution of apholate synergist, stirring are contained according to every 1000mL
To uniform, dry, synergy quinestrol pharmaceutical chemistry is made.
The compound method of common quinestrol pharmaceutical chemistry solution is, according to the quinestrol that 200g is added in every 1000mL water, to stir
Mix to being completely dissolved.Fresh paddy 500kg is weighed, the quinestrol solution 1000mL prepared is added, contains according to every 1000mL
500kg bait material is added in the sterile agent solution of apholate, is stirred until homogeneous, dries, common quinestrol pharmaceutical chemistry is made.
Take the synergy quinestrol apholate pharmaceutical chemistry prepared, traditional quinestrol pharmaceutical chemistry and blank paddy bait feeding small white mouse with
Rattus losea compares, and food ration and sterile rate are respectively as shown in table 2 and table 3：
Table 2
Table 3
As can be seen from Table 2：Rattus losea and small white mouse are significantly higher than to common alkynes to the food ingestion of synergy quinestrol paddy bait
The food ingestion of female ether paddy bait, dimethylformamide can improve the food ingestion of Rattus losea and small white mouse to quinestrol, increase quinestrol
Palatability.Small white mouse low reproduction rate after feeding synergy quinestrol paddy bait it can be seen from the result of table 3 is in blank paddy bait group
With common quinestrol paddy bait group, it breeds filial generation number and survival offspring individual number is below blank paddy bait group and common quinestrol
Paddy bait group.Show that dimethylformamide has synergistic effect to the sterile effect of quinestrol.
Embodiment 3：
Tween-80 100mL are measured, 20 DEG C of water 1000mL is added, stirs and evenly mixs, dimethylformamide 100mL is added, stirs
Mix mixing；The synergist solution 1000mL after mixing is weighed, mifepristone 100g is added, according to every 1000mL apholates synergist
Middle addition 100g mifepristone, stirring is to being completely dissolved.Fresh paddy 500kg is weighed, adds the synergy meter Fei Si prepared
Ketone solution 1000mL, the bait material that 500kg is added in the sterile agent solution of apholate synergist is contained according to every 1000mL, is stirred
Mix to uniform, dry, synergy mifepristone pharmaceutical chemistry is made.
The compound method of common mifepristone pharmaceutical chemistry solution is, according to the meter Fei Si that 200g is added in every 1000mL water
Ketone, stirring is to being completely dissolved.Fresh paddy 500kg is weighed, the mifepristone solution 1000mL prepared is added, according to every
500kg bait material is added in the sterile agent solution that 1000mL contains apholate, is stirred until homogeneous, dries, is made commonly
Mifepristone pharmaceutical chemistry.
Take the synergy mifepristone apholate pharmaceutical chemistry prepared, traditional mifepristone pharmaceutical chemistry and blank paddy bait feeding little Bai
Mouse, compare food ration and sterile rate：
Table 4
Table 5
As can be seen from Table 4：Small white mouse is higher than to common mifepristone paddy bait to the food ingestion of synergy mifepristone paddy bait
Food ingestion, dimethylformamide can improve the palatability of mifepristone.The feeding mifepristone it can be seen from the result of table 5
Small white mouse low reproduction rate after paddy bait is in blank paddy bait group, its breeding filial generation number of synergy mifepristone paddy bait group and survival filial generation
Number of individuals is below blank paddy bait group and common mifepristone paddy bait group.Show that dimethylformamide is imitated to the infertility of mifepristone
Fruit has synergistic effect.
Embodiment 4：
Tween-80 100ml are measured, 20 DEG C of water 20L is added, stirs and evenly mixs, add dimethylformamide 2000ml, stirring
Mix；The apholate synergist solution 20L after mixing is weighed, quinestrol 100g is added, according to every 1000mL apholates synergist
5g quinestrol is added in solution, stirring is to being completely dissolved.Fresh wheat 490kg is weighed, adds the synergy quinestrol prepared
Solution 20L, the bait material that 24.5kg is added in the quinestrol solution of apholate synergist is contained according to every 1000mL, stirring is extremely
Uniformly, dry, synergy quinestrol pharmaceutical chemistry is made.
The compound method of common quinestrol pharmaceutical chemistry solution is, according to the quinestrol that 10g is added in every 1000mL water, stirring
To being completely dissolved.Fresh wheat 490kg is weighed, the quinestrol solution 20L prepared is added, contains apholate according to every 1000mL
24.5kg bait material is added in the sterile agent solution of synergist, is stirred until homogeneous, dries, common quinestrol medicine is made
Bait.
Table 6
Small white mouse breeding potential after feeding quinestrol wheat pharmaceutical chemistry it can be seen from the result of table 6 is below blank group, increases
Its breeding filial generation number of effect quinestrol wheat pharmaceutical chemistry group and survival offspring individual number are below blank wheat-based bait group and common alkynes
Female ether wheat pharmaceutical chemistry group.Show that dimethylformamide has synergistic effect to the sterile effect of quinestrol.
The explanation of above example is only intended to help and understands technical scheme and its core concept, should refer to
Go out, to those of ordinary skill in the art, under the premise without departing from the principles of the invention, the present invention can also be carried out
Some improvement and modification, these are improved and modification is also fallen into the protection domain of the claims in the present invention.
Claims (7)
- A kind of 1. rodents sterilant synergist, it is characterised in that including dimethylformamide, Tween-80 and water, the diformazan The volume ratio of base formamide, Tween-80 and water is 10~20:1~10:100~200.
- 2. a kind of preparation method of the rodents sterilant synergist described in claim 1, comprises the following steps：(1) Tween-80 of formula ratio is dissolved with water, 20~45 DEG C of water temperature；(2) dimethylformamide is added into above-mentioned solution, rodents sterilant synergist is made to being completely dissolved in stirring.
- A kind of 3. muroid bait material, it is characterised in that：Comprising the rodents sterilant synergist described in claim 1 as activity Composition.
- 4. application of the rodents sterilant synergist in muroid bait material is prepared described in claim 1, it is characterised in that bag Include following steps：(1) add rodents sterilant into apholate synergist to be stirred until homogeneous, according in every 1000mL apholates synergist adding Add 5~100g rodents sterilant, form the sterile agent solution containing apholate synergist；(2) add bait material in the sterile agent solution containing apholate synergist in step (1) to stir, according to every 24.5~500kg bait material is added in the sterile agent solution that 1000mL contains apholate synergist, dries or dries, produce Muroid bait material containing apholate synergist.
- 5. application of the rodents sterilant synergist according to claim 4 in muroid bait material is prepared, its feature exist In the rodents sterilant of described step (1) is fat-soluble apholate or water-soluble apholate.
- 6. application of the rodents sterilant synergist according to claim 5 in muroid bait material is prepared, its feature exist In described rodents sterilant is quinestrol, mifepristone or Cabergoline.
- 7. application of the rodents sterilant synergist according to claim 4 in muroid bait material is prepared, its feature exist In the bait material of the step (2) is selected from one or more of paddy, wheat and sorghum.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710580552.8A CN107455374B (en) | 2017-07-17 | 2017-07-17 | Murine sterilant synergist and application thereof in preparation of murine bait material |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710580552.8A CN107455374B (en) | 2017-07-17 | 2017-07-17 | Murine sterilant synergist and application thereof in preparation of murine bait material |
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| CN107455374A true CN107455374A (en) | 2017-12-12 |
| CN107455374B CN107455374B (en) | 2020-06-16 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111685110A (en) * | 2020-06-29 | 2020-09-22 | 广东省农业科学院植物保护研究所 | Application of N, N-dimethylformamide in anticoagulant rodenticide penetrant |
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| CN1628772A (en) * | 2004-08-31 | 2005-06-22 | 吴成奎 | Botanical originated nim oil contraception formulation |
| CN101181270A (en) * | 2007-11-13 | 2008-05-21 | 浙江金力制药有限公司 | Hydrochloric acid lomefloxacin injection and preparation method thereof |
| CN101869113A (en) * | 2010-06-17 | 2010-10-27 | 中国农业科学院植物保护研究所 | Cyclodextrin inclusion compound of rodents sterilant and preparation method thereof |
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2017
- 2017-07-17 CN CN201710580552.8A patent/CN107455374B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3882240A (en) * | 1970-11-27 | 1975-05-06 | Upjohn Co | Method for producing infertility in male rats |
| CN1628772A (en) * | 2004-08-31 | 2005-06-22 | 吴成奎 | Botanical originated nim oil contraception formulation |
| CN101181270A (en) * | 2007-11-13 | 2008-05-21 | 浙江金力制药有限公司 | Hydrochloric acid lomefloxacin injection and preparation method thereof |
| CN101869113A (en) * | 2010-06-17 | 2010-10-27 | 中国农业科学院植物保护研究所 | Cyclodextrin inclusion compound of rodents sterilant and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 秦姣等: "米非司酮对雄性小鼠繁殖抑制作用研究", 《广东农业科学》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111685110A (en) * | 2020-06-29 | 2020-09-22 | 广东省农业科学院植物保护研究所 | Application of N, N-dimethylformamide in anticoagulant rodenticide penetrant |
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