CN107441307A - 一种治疗猪链球菌病的组合物 - Google Patents
一种治疗猪链球菌病的组合物 Download PDFInfo
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Abstract
本发明涉及兽药技术领域,特别涉及一种治疗猪链球菌病的组合物;包括以下按重量份计的原料:防己20~30、伸筋草10~20、萹蓄12~18、海金沙2~4、赤小豆15~25、旱莲草6~9、枇杷叶12~18、香薷10~20、细辛3~8、葱白8~12、诃子6~9、金樱子2~4、紫苑5~8、乌蔹莓8~12;本发明的组合物,对猪链球菌病具有显著的治疗效果,对猪链球菌病的治愈率在94%以上,有效灭杀感染猪链球菌病的病原菌及其病毒,有效改善了猪链球菌病的治疗效果,对提高猪生产性能、减少经济损失、促进猪养殖业持续健康发展发挥了极其重要的意义。
Description
技术领域
本发明涉及兽药技术领域,特别涉及一种治疗猪链球菌病的组合物。
背景技术
猪养殖作为农业产业的延伸,不仅在中国传统养殖业中占有十分重要的位置,而且一直在禽畜业生产中处于主导地位,猪养殖产业的健康发展是解决农民增收的重要途径之一,也是保证居民肉食消费的重要来源之一,发展猪养殖产业是促进中国农民增收致富、农村剩余劳动力转移的重要途径,猪肉产品的稳定供应已经成为解决农民增收和国计民生的重要环节,但是高发性且危害极大的猪链球菌病是严重阻碍猪养殖业健康发展的绊脚石。
猪链球菌是具有荚膜的一种革兰氏阳性球菌。可根据其细胞壁抗原成分将其大致归类为兰氏分群(LancefieldgroupD)D群链球菌,根据其荚膜抗原(CPS)的不同,猪链球菌被分为35(1~34型,1/2型)种血清型,其中1,2,7,9型是猪的致病菌。猪链球菌的定植部位为猪的上呼吸道,尤其是扁桃体和鼻腔。部分血清型的猪链球菌具有致病性,主要通过伤口感染。可引起猪的急性败血症(septicemiawithsuddendeath)、脑膜炎(meningitis)、关节炎(arthritis)、心内膜炎(endocarditis)、肺炎(pneumonia)等疾病。部分菌株可引起人类感染,造成细菌性脑炎(bacterialmeningitis)或引起中毒样休克综合征(toxicshock-likesyndrome),急性败血型急性型猪链球菌病发病急、传播快,多表现为急性败血型。病猪突然发病,体温升高至41℃~43℃,精神沉郁、嗜睡、食欲废绝,流鼻水,咳嗽,眼结膜潮红、流泪,呼吸加快。多数病猪往往头晚未见任何症状,次晨已死亡。少数病猪在病的后期,于耳尖、四肢下端、背部和腹下皮肤出现广泛性充血、潮红。
目前中草药具有药源广泛、高效、抗药性不显著、毒副作用小等优点,在治疗猪链球菌病过程中,除了兼有药性和营养性外,还具有提高猪的生产性能和饲料利用率的功效,所以越来越受到重视,应用也日益广泛,所以,鉴于中草药的一系列特点,将中草药运用在猪链球菌病的治疗上是具有积极意义的,如申请号201510678542.9《一种治疗猪链球菌病的兽药》公开了一种治疗猪链球菌病的兽药,由下列重量的中药材制成:湖北贝母120g、泽泻45g、玫瑰花20g、银杏叶20g、番泻叶20g、淡豆豉15g、菊苣10g、黄芥子3g、刀豆140g、山药65g、韭菜子30g、首乌藤25g、土茯苓20g、山茱萸10g、麦芽10g、昆布10g、薏苡仁7g、薤白7g、金荞麦5g,但是从现有的专利与论文来看,针对猪链球菌病的中草药制剂的研究虽取得一定成效,但是由于目前制剂的配方不合理,以及猪链球菌病发病的随机性和高发性等特点,使得目前的中药药物治疗效果不是很理想,导致出现了发病率很高,治愈率很低的现象,严重制约了猪养殖业的发展,因此,针对猪链球菌病病原菌的发病特点,降低发病率,提高猪链球菌病治愈率,对猪养殖业的健康发展具有重要的现实意义和经济意义。
发明内容
本发明为解决上述技术问题,提供了一种治疗猪链球菌病的组合物。
具体是通过以下技术方案来实现的:
一种治疗猪链球菌病的组合物,包括以下按重量份计的原料:防己20~30、伸筋草10~20、萹蓄12~18、海金沙2~4、赤小豆15~25、旱莲草6~9、枇杷叶12~18、香薷10~20、细辛3~8、葱白8~12、诃子6~9、金樱子2~4、紫苑5~8、乌蔹莓8~12。
包括以下按重量份计的原料:防己25、伸筋草15、萹蓄15、海金沙3、赤小豆20、旱莲草8、枇杷叶15、香薷15、细辛5、葱白10、诃子8、金樱子3、紫苑7、乌蔹莓10。
所述的治疗猪链球菌病的组合物,为颗粒剂、口服制剂或注射剂。
所述的颗粒剂,是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,烘干粉碎,得中药粉,加入中药粉质量的20~30%的预胶化淀粉,拌匀,用乙醇浸润,通过造粒机造粒即可。
所述的口服制剂,是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,加水熬煮,过滤,再加水熬煮滤渣,重复三次,将三次滤液合并,浓缩至合并液体积的1/2,加入浓缩液质量的20~30%的糖浆剂,拌匀即可。
所述的注射制剂,是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,粉碎,用水蒸气蒸馏法蒸馏,收集馏液,再进行重蒸馏,收集重蒸馏液,再加入重蒸馏液质量的1~1.2%倍的氯化钠,和重蒸馏液质量的0.5~0.6%倍的聚山梨酯80,搅拌溶解,用G4垂熔玻璃漏斗过滤至澄清,灌封,100℃下灭菌30min,即可。
对本发明的组合物对育肥猪链球菌病的治疗效果进行统计:
1、随机选取若干头年龄、经红细胞血凝试验确诊患有猪链球菌病的母猪,随机分为2组,采用日常管理方式进行喂养,且均由同一人进行喂养,不同之处在于,第一组将本实施例1~5制备的任一组合物与日粮混合(其中混合比例见实施例1~5),对母猪进行喂食,第二组在日粮中添加申请号201510678542.9《一种治疗猪链球菌病的兽药》的治疗猪链球菌病的药物,添加量同第一组,试验时间为30d,分别对猪链球菌病的治疗情况进行统计,结果如表1所示:
表1
项目 | 治愈率% | 有效率% |
第一组 | 94.8 | 98.6 |
第二组 | 90 | 95.7 |
综上所述,本发明的有益效果在于:本发明的组合物,对猪链球菌病具有显著的治疗效果,对猪链球菌病的治愈率在94%以上,有效灭杀感染猪链球菌病的病原菌及其病毒,并且具有广谱性,同时,也提高了猪的免疫抵抗力,提升自身的抗逆性,降低染病的风险,有效改善了猪链球菌病的治疗效果,对提高猪生产性能、减少经济损失、促进猪养殖业持续健康发展发挥了极其重要的意义。
具体实施方式
下面对本发明的具体实施方式作进一步详细的说明,但本发明并不局限于这些实施方式,任何在本实施例基本精神上的改进或代替,仍属于本发明权利要求所要求保护的范围。
实施例1
一种治疗猪链球菌病的组合物,包括以下按重量份计的原料:防己20kg、伸筋草10kg、萹蓄12kg、海金沙2kg、赤小豆15kg、旱莲草6kg、枇杷叶12kg、香薷10kg、细辛3kg、葱白8kg、诃子6kg、金樱子2kg、紫苑5kg、乌蔹莓8kg。
所述的治疗猪链球菌病的组合物,其制备方法是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,烘干粉碎,得中药粉,加入中药粉质量的20~30%的预胶化淀粉,拌匀,用乙醇浸润,通过造粒机造粒,即得颗粒剂。
当猪发病时,将制备的颗粒剂与猪日粮按18~22%:1的质量比混合,对猪进行喂食。
实施例2
一种治疗猪链球菌病的组合物,包括以下按重量份计的原料:防己30kg、伸筋草20kg、萹蓄18kg、海金沙4kg、赤小豆25kg、旱莲草9kg、枇杷叶18kg、香薷20kg、细辛8kg、葱白12kg、诃子9kg、金樱子4kg、紫苑8kg、乌蔹莓12kg。
所述的治疗猪链球菌病的组合物,其制备方法是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,加水熬煮,过滤,再加水熬煮滤渣,重复三次,将三次滤液合并,浓缩至合并液体积的1/2,加入浓缩液质量的20~30%的糖浆剂,拌匀即得口服制剂。
当猪发病时,将制备的口服制剂按5~8ml/10kg的量对猪进行灌服。
实施例3
一种治疗猪链球菌病的组合物,包括以下按重量份计的原料:防己25kg、伸筋草15kg、萹蓄15kg、海金沙3kg、赤小豆20kg、旱莲草8kg、枇杷叶15kg、香薷15kg、细辛5kg、葱白10kg、诃子8kg、金樱子3kg、紫苑7kg、乌蔹莓10kg。
所述的治疗猪链球菌病的组合物,其制备方法是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,粉碎,用水蒸气蒸馏法蒸馏,收集馏液,再进行重蒸馏,收集重蒸馏液,再加入重蒸馏液质量的1~1.2%倍的氯化钠,和重蒸馏液质量的0.5~0.6%倍的聚山梨酯80,搅拌溶解,用G4垂熔玻璃漏斗过滤至澄清,灌封,100℃下灭菌30min,即得注射制剂。
当猪发病时,将制备的注射制剂按0.13~0.15ml/kg的量对猪进行注射。
实施例4
一种治疗猪链球菌病的组合物,包括以下按重量份计的原料:防己20kg、伸筋草20kg、萹蓄12kg、海金沙4kg、赤小豆15kg、旱莲草9kg、枇杷叶12kg、香薷20kg、细辛3kg、葱白12kg、诃子6kg、金樱子4kg、紫苑5kg、乌蔹莓12kg。
所述的治疗猪链球菌病的组合物,其制备方法是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,加水熬煮,过滤,再加水熬煮滤渣,重复三次,将三次滤液合并,浓缩至合并液体积的1/2,加入浓缩液质量的20~30%的糖浆剂,拌匀即得口服制剂。
当猪发病时,将制备的口服制剂按5~8ml/10kg的量对猪进行灌服。
实施例5
一种治疗猪链球菌病的组合物,包括以下按重量份计的原料:防己30kg、伸筋草10kg、萹蓄18kg、海金沙2kg、赤小豆25kg、旱莲草6kg、枇杷叶18kg、香薷10kg、细辛8kg、葱白8kg、诃子9kg、金樱子2kg、紫苑8kg、乌蔹莓12kg。
所述的治疗猪链球菌病的组合物,其制备方法是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,烘干粉碎,得中药粉,加入中药粉质量的20~30%的预胶化淀粉,拌匀,用乙醇浸润,通过造粒机造粒,即得颗粒剂。
当猪发病时,将制备的颗粒剂与猪日粮按18~22%:1的质量比混合,对猪进行喂食。
随机选取健康状况、活动能立强、年龄相同的育肥猪若干头,随机分为6组,每组数量相同,采用日常管理方式进行喂养,且均由同一人进行喂养,不同之处在于,当发现育肥出现猪链球菌病的现象时,将病育肥猪隔离,1~5组分别将本实施例1~5制备的任一组合物与日粮混合(其中混合比例见实施例1~5),对育肥猪进行喂食,第6组在日粮中添加申请号201510678542.9《一种治疗猪链球菌病的兽药》的治疗猪链球菌病的药物,添加量同第前五组,并观察时间为一个月,分别对治疗情况进行统计,结果如表2所示:
表2
项目 | 平均治愈率% | 平均有效率% |
实施例1 | 94.8 | 98.6 |
实施例2 | 95.1 | 98.4 |
实施例3 | 95.3 | 98.8 |
实施例4 | 94.7 | 98.5 |
实施例5 | 94.5 | 98.7 |
公开治疗药物 | 90 | 95.7 |
Claims (6)
1.一种治疗猪链球菌病的组合物,其特征在于,包括以下按重量份计的原料:防己20~30、伸筋草10~20、萹蓄12~18、海金沙2~4、赤小豆15~25、旱莲草6~9、枇杷叶12~18、香薷10~20、细辛3~8、葱白8~12、诃子6~9、金樱子2~4、紫苑5~8、乌蔹莓8~12。
2.如权利要求1所述的治疗猪链球菌病的组合物,其特征在于,包括以下按重量份计的原料:防己25、伸筋草15、萹蓄15、海金沙3、赤小豆20、旱莲草8、枇杷叶15、香薷15、细辛5、葱白10、诃子8、金樱子3、紫苑7、乌蔹莓10。
3.如权利要求1所述的治疗猪链球菌病的组合物,其特征在于,为颗粒剂、口服制剂或注射剂。
4.如权利要求3所述的治疗猪链球菌病的组合物,其特征在于,所述的颗粒剂,是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,烘干粉碎,得中药粉,加入中药粉质量的20~30%的预胶化淀粉,拌匀,用乙醇浸润,通过造粒机造粒即可。
5.如权利要求3所述的治疗猪链球菌病的组合物,其特征在于,所述的口服制剂,是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,加水熬煮,过滤,再加水熬煮滤渣,重复三次,将三次滤液合并,浓缩至合并液体积的1/2,加入浓缩液质量的20~30%的糖浆剂,拌匀即可。
6.如权利要求3所述的治疗猪链球菌病的组合物,其特征在于,所述的注射制剂,是将防己、伸筋草、萹蓄、海金沙、赤小豆、旱莲草、枇杷叶、香薷、细辛、葱白、诃子、金樱子、紫苑、乌蔹莓按配方量称取后,粉碎,用水蒸气蒸馏法蒸馏,收集馏液,再进行重蒸馏,收集重蒸馏液,再加入重蒸馏液质量的1~1.2%倍的氯化钠,和重蒸馏液质量的0.5~0.6%倍的聚山梨酯80,搅拌溶解,用G4垂熔玻璃漏斗过滤至澄清,灌封,100℃下灭菌30min,即可。
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