CN107426997A - 使用n‑乙酰半胱氨酸酰胺治疗视网膜色素变性 - Google Patents

使用n‑乙酰半胱氨酸酰胺治疗视网膜色素变性 Download PDF

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Publication number
CN107426997A
CN107426997A CN201580072224.6A CN201580072224A CN107426997A CN 107426997 A CN107426997 A CN 107426997A CN 201580072224 A CN201580072224 A CN 201580072224A CN 107426997 A CN107426997 A CN 107426997A
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CN
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Prior art keywords
naca
method described
acid
agent
given
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Pending
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CN201580072224.6A
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English (en)
Chinese (zh)
Inventor
P·A·坎波基亚罗
D·哈特曼
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Brighton Biotech Inc
Johns Hopkins University
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Brighton Biotech Inc
Johns Hopkins University
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Priority to CN201810698779.7A priority Critical patent/CN108498495A/zh
Publication of CN107426997A publication Critical patent/CN107426997A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
CN201580072224.6A 2014-11-07 2015-11-06 使用n‑乙酰半胱氨酸酰胺治疗视网膜色素变性 Pending CN107426997A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810698779.7A CN108498495A (zh) 2014-11-07 2015-11-06 使用n-乙酰半胱氨酸酰胺治疗视网膜色素变性

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462076594P 2014-11-07 2014-11-07
US62/076594 2014-11-07
PCT/US2015/059589 WO2016073931A1 (en) 2014-11-07 2015-11-06 Treatment of retinitis pigmentosa with n-acetylcysteine amide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810698779.7A Division CN108498495A (zh) 2014-11-07 2015-11-06 使用n-乙酰半胱氨酸酰胺治疗视网膜色素变性

Publications (1)

Publication Number Publication Date
CN107426997A true CN107426997A (zh) 2017-12-01

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CN201580072224.6A Pending CN107426997A (zh) 2014-11-07 2015-11-06 使用n‑乙酰半胱氨酸酰胺治疗视网膜色素变性
CN201810698779.7A Pending CN108498495A (zh) 2014-11-07 2015-11-06 使用n-乙酰半胱氨酸酰胺治疗视网膜色素变性

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Country Status (11)

Country Link
US (2) US20180296503A1 (enExample)
EP (2) EP3214934A4 (enExample)
JP (5) JP2017533969A (enExample)
KR (3) KR20230152177A (enExample)
CN (2) CN107426997A (enExample)
AU (4) AU2015342831B2 (enExample)
BR (1) BR112017009584A2 (enExample)
CA (1) CA2967327C (enExample)
HK (1) HK1252822A1 (enExample)
RU (1) RU2711913C2 (enExample)
WO (2) WO2016073931A1 (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN109096161A (zh) * 2018-08-24 2018-12-28 武汉远大弘元股份有限公司 一种n-乙酰半胱氨酸的制备方法

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US10752593B2 (en) 2018-12-28 2020-08-25 Endogena Therapeutics, Inc. Compounds for use as therapeutically active substances in the treatment of retinal diseases
RU2711913C2 (ru) 2014-11-07 2020-01-24 Дзе Джонс Хопкинс Юниверсити Лечение пигментной дистрофии сетчатки n-ацетилцистеинамидом
US11268964B2 (en) 2014-11-11 2022-03-08 The Johns Hopkins University Biomarkers useful in the treatment of subjects having diseases of the eye
CN111386255B (zh) 2017-09-20 2021-11-23 纳崔泰制药有限公司 用于制备n-乙酰基半胱氨酸酰胺及其衍生物的方法
US11548851B2 (en) 2017-09-20 2023-01-10 Nacuity Pharmaceuticals, Inc. Method for preparation of n-acetyl cysteine amide and derivatives thereof
US11091433B2 (en) 2017-09-20 2021-08-17 Nacuity Pharmaceutials, Inc. Method for preparation of N-acetyl cysteine amide and derivatives thereof
US20190135741A1 (en) * 2017-11-09 2019-05-09 Nacuity Pharmaceuticals, Inc. Methods of Making Deuterium-Enriched N-acetylcysteine Amide (D-NACA) and (2R, 2R')-3,3'-Disulfanediyl BIS(2-Acetamidopropanamide) (DINACA) and Using D-NACA and DINACA to Treat Diseases Involving Oxidative Stress
US20190151271A1 (en) * 2017-11-21 2019-05-23 The Johns Hopkins University Compositions and methods for treatment of eye diseases
WO2020011607A1 (en) * 2018-07-09 2020-01-16 Fondation Asile Des Aveugles Inhibition of prc2 subunits to treat eye disorders
US10807973B2 (en) 2018-12-28 2020-10-20 Endogena Therapeutics, Inc. Compounds for use as therapeutically active substances in the treatment of retinal diseases
US12245998B2 (en) 2019-01-11 2025-03-11 Nacuity Pharmaceuticals, Inc. N-acetylcysteine amide (NACA) and (2R,2R′)-3,3′ disulfanediyl bis(2-acetamidopropanamide) (diNACA) for the prevention and treatment of radiation pneumonitis and treatment of pulmonary function in Cystic Fibrosis
US11766413B2 (en) 2019-01-11 2023-09-26 Nacuity Pharmaceuticals, Inc. Treatment of age-related macular degeneration, glaucoma, and diabetic retinopathy with n-acetylcysteine amide (NACA) or (2R,2R′)-3,3′-disulfanediyl BIS(2-acetamidopropanamide)(DiNACA)
US12458608B2 (en) 2019-01-11 2025-11-04 Nacuity Pharmaceuticals, Inc. N-Acetylcysteine Amide (NACA) and (2R,2R′)-3,3′ disulfanediyl BIS(2-acetamidopropanamide) (DINACA) for the prevention and treatment of radiation dermatitis and skin lightening, skin whitening and skin improvement
WO2021151044A1 (en) * 2020-01-24 2021-07-29 Nacuity Pharmaceuticals, Inc. Prodrug for the treatment of disease and injury of oxidative stress

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US20170333375A1 (en) 2017-11-23
WO2016073931A1 (en) 2016-05-12
JP2021193119A (ja) 2021-12-23
JP2020023549A (ja) 2020-02-13
BR112017009584A2 (pt) 2017-12-26
RU2017119230A (ru) 2018-12-10
US20180296503A1 (en) 2018-10-18
AU2015342831B2 (en) 2019-09-12
AU2015342831A1 (en) 2017-05-25
WO2016073829A2 (en) 2016-05-12
EP3214934A1 (en) 2017-09-13
CA2967327C (en) 2020-04-28
JP2017533969A (ja) 2017-11-16
AU2019261762A1 (en) 2019-11-28
AU2021225263B2 (en) 2023-11-02
WO2016073829A9 (en) 2016-06-23
JP2023145734A (ja) 2023-10-11
KR20220039853A (ko) 2022-03-29
EP4000612A1 (en) 2022-05-25
RU2711913C2 (ru) 2020-01-24
KR20170109527A (ko) 2017-09-29
EP3214934A4 (en) 2018-06-20
US12472157B2 (en) 2025-11-18
CN108498495A (zh) 2018-09-07
AU2019261762B2 (en) 2021-06-10
AU2021225263A1 (en) 2021-09-30
JP2025160381A (ja) 2025-10-22
HK1252822A1 (zh) 2019-06-06
RU2017119230A3 (enExample) 2018-12-10
AU2024200436A1 (en) 2024-02-08
KR20230152177A (ko) 2023-11-02
CA2967327A1 (en) 2016-05-12

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