CN107413403A - Constant temperature sample introduction thermal insulation converging device - Google Patents
Constant temperature sample introduction thermal insulation converging device Download PDFInfo
- Publication number
- CN107413403A CN107413403A CN201710063803.5A CN201710063803A CN107413403A CN 107413403 A CN107413403 A CN 107413403A CN 201710063803 A CN201710063803 A CN 201710063803A CN 107413403 A CN107413403 A CN 107413403A
- Authority
- CN
- China
- Prior art keywords
- duct
- heat insulation
- taper
- sample introduction
- constant temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/02—Water baths; Sand baths; Air baths
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
- B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1894—Cooling means; Cryo cooling
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The present invention relates to a kind of combination constant temperature sample introduction and the device at adiabatic interflow, it is made up of thermostat, heat insulation taper cock and gland.Heat insulation taper cock is by gland elastic compression and is maintained in the taper consent of thermostat, taper consent and heat insulation taper cock are provided with three tunnels and are used for the horizontal inflow duct of sample introduction and flow out duct all the way, and the heat insulation taper cock is provided with described in three tunnels coordinated with flowing into duct described in three tunnels of taper consent and flows into duct.Compact overall structure, it is not easy to reveal, thermal stability is good, can various modes sample introduction, realize that single current enters single exit case, double fluid enters single exit case and three flow into single exit case, automaticity is high, and adaptability is good, biochemical analysis, bioengineering and chemical synthesis, preparation field are can be applied to, being applied especially to live thermometric analysis and test has advantage.
Description
Technical field
Patent of the present invention is related to a kind of sample introduction converging device, can especially with reference to constant temperature sample introduction and adiabatic converging device
Apply in the field such as various biochemical analysises, bioengineering and chemical synthesis, preparation field and biology sensor.
Background technology
The technological process of biochemistry is generally required to carry out multiple sample interflow and mixed, and stationary temperature is to ensure biochemistry
Reaction meets the necessary condition of technological requirement.
Thermometric analysis is applied to most of biochemical reaction, not by the shadow of the sample properties such as color, muddiness and electrochemistry
Ring, and the Cleaning Principle of calorimetric method is simple, reliable, is increasingly becoming the field such as food security, environment, medical science quick detection and opens
The important directions of hair.At present, thermometric analysis has a variety of streams combinations and analysis mode（Enrichment, detection integrated calorimetric formula biology
Sensor, ZL 200910126677.9；Based on the calorimetric biosensor of reversible immobilised enzymes, ZL
200910126676.4）, especially thermometric analysis requirement sample introduction should be adiabatic at interflow, but the diabatic process needed for constant temperature
Contradiction is formd with the insulation requirements at sample introduction interflow, the simple scheme using the mixing of metal derby interflow can not meet to require（Enzyme heat
Bioreactor sample introduction blender, ZL 201420054107.X）.
Flow Injection Analysis theory shows that the length of stream has a great influence to analysis result in analytical equipment, therefore analyzes stream
Road shortening is favourable to analyzing, and considers as the heat-insulated of analytical equipment and connection, it is desirable to which constant temperature sample introduction and the structure at adiabatic interflow are tight
Gather and facilitate combination.
The content of the invention
The defects of collaborating technology present invention aim to address sample introduction in existing biochemistry, there is provided one kind is entered with reference to constant temperature
Sample and the device at adiabatic interflow.
The technical solution adopted for the present invention to solve the technical problems is：Constant temperature sample introduction thermal insulation converging device by thermostat,
Heat insulation taper cock and gland composition, the thermostat are provided with the taper consent coordinated with the heat insulation taper cock, institute
Heat insulation taper cock is stated by gland elastic compression and is maintained in taper consent, the taper consent side be provided with three tunnels be used for into
The horizontal of sample flows into duct, and the heat insulation taper cock is provided with three tunnels coordinated with flowing into duct described in three tunnels of taper consent
The inflow duct, the central axis in inflow duct passes through the axle center of the heat insulation taper cock, three tunnel institutes described in three tunnels
State flow into duct level stop at heat insulation taper cock axle center and extend vertically upwards perforate vertically, as outflow duct,
The length in inflow duct is identical described in three tunnels, and the horizontal sextant angle in the adjacent inflow duct is identical.
The thermostat is made up of high chemically inert metal material, preferably stainless steel.
The thermostat carries out temperature control and constant temperature by external heat/refrigerating plant, and preferably semiconductor heating/refrigerating fills
Put.
The heat insulation taper cock is made up of high chemically inert heat insulator, preferably polytetrafluoroethylene (PTFE)（It is hydrophilic
Change and be modified）.
Further, switched over by rotating the heat insulation taper cock, the inflow duct of the thermostat
It is respectively communicated with the inflow duct of the heat insulation taper cock and flows into duct all the way, two roads flows into duct and the inflow of three tunnels
Duct, realize that single current enters single exit case, double fluid enters single exit case and three flow into single exit case, sample introduction flows through the inflow duct of thermostat
When by constant temperature, then pass through the inflow duct of the heat insulation taper cock and stream collected by flow pass interflow
Go out.
Further, by setting the taper consent, the heat insulation taper cock, the ostium of twinned structure
Road and the gland are combined as one group of Measurement channel and reference channel, be such as multiplied survey simultaneously respectively as measurement and reference
Passage and reference channel are measured, sample introduction while multigroup passage can be achieved.
The invention has the advantages that realizing constant temperature sample introduction and adiabatic interflow, compact overall structure, drift ice quantity is short, cone
Shape face coordinates easily connection, is not easy to reveal, thermal stability is good；Thermostatic mode is flexible, can use semiconductor heating/refrigerating, water
The modes such as heating/refrigerating；It can conveniently combine, various modes sample introduction, realize that single current enters single exit case, double fluid enters single exit case and three streams
Enter single exit case, automaticity is high；Reference measurement can be realized, what is obtained is difference component, eliminates nonspecific interference, reduces and misses
Difference, sample introduction while improving measurement accuracy and realize multiplexer channel；Adaptability is good, can be applied to biochemical analysis, bioengineering and
Chemical synthesis, preparation field, being applied especially to live thermometric analysis and test has advantage.
Brief description of the drawings
The present invention is further described with reference to the accompanying drawings and examples.
Fig. 1 is the cross-sectional view of the present invention.
Fig. 2 is the overlooking the structure diagram of the present invention.
Fig. 3 is the structural representation of heat insulation taper cock.
Fig. 4 is the principle schematic that heat insulation taper cock switches inflow and outflow pattern counterclockwise.
Wherein：1st, thermostat, 2, heat insulation taper cock, 3, taper consent, 4, gland, 5, flow into duct, 6, tap hole
Road.
Embodiment
The present invention combine nationality by below in conjunction with embodiment illustrate the content of the present invention, the model that is not intended to limit the present invention
Enclose.
As depicted in figs. 1 and 2, constant temperature sample introduction thermal insulation converging device is by 4 groups of thermostat 1, heat insulation taper cock 2 and gland
Into thermostat 1 is polygon stainless steel metal block, and the bottom of thermostat 1 carries out temperature control simultaneously by semiconductor heating/refrigerating device
Constant temperature, thermostat 1 are provided with the taper consent 3 coordinated with heat insulation taper cock 2, and heat insulation taper cock 2 relies on bullet by gland 4
Spring force is compressed and is maintained in taper consent 3, and the top of heat insulation taper cock 2 is disposed with the projection of semicolumn hemicone, knot
Structure ensures that runner is closed as shown in figure 3, end socket for inserting microresponse device entrance.The side of taper consent 3 is provided with three tunnels and is used for
The inflow duct 5 of sample introduction, heat insulation taper cock 2 are provided with the three road ostiums for flowing into duct 5 with three tunnels of taper consent 3 and coordinating
Road 5, the central axis that three roads flow into duct 5 flow into the length phase in duct 5 by the axle center of heat insulation taper cock 2, three roads
Together, and the adjacent inflow horizontal sextant angle of duct 5 is 45 °, and three roads flow into the level of duct 5 and stop at the axle center of heat insulation taper cock 2 simultaneously
Perforate is extended vertically upwards vertically, as outflow duct 6.Heat insulation taper cock 2 and gland 4 are by polytetrafluoroethylene (PTFE)（Parent
Aquation is modified）Material is made.
As shown in figure 4,45 ° and 90 ° of the anglec of rotation is distinguished in heat insulation taper cock 2 counterclockwise, three tunnels of thermostat 1 flow into
Duct 5 flows into duct 5 with three tunnels of heat insulation taper cock 2 and connects inflow duct 5, the two tunnels inflow road of duct 5 and three stream all the way
Enter duct 5, realize three inflow single exit cases（Fig. 4 a）, double fluid enter single exit case（Fig. 4 b）Enter single exit case with single current（Fig. 4 c）, sample introduction stream
By constant temperature when crossing the inflow duct 5 of thermostat 1, three roads for then passing through heat insulation taper cock 2 flow into duct 5 and pass through outflow
Collect outflow in the interflow of passage 6.Heat insulation taper cock 2, which turns clockwise, can also realize above-mentioned function, and principle is consistent.
As depicted in figs. 1 and 2, by setting the taper consent 2 of twinned structure, heat insulation taper cock 3, gland 4, flowing into
Duct 5 and outflow duct 6 are combined as one group of Measurement channel and reference channel respectively as measurement and reference.Further, as
When be multiplied Measurement channel and reference channel, sample introduction while multigroup passage can be achieved.
Claims (5)
1. a kind of constant temperature sample introduction thermal insulation converging device, is made up of thermostat, heat insulation taper cock and gland, it is characterised in that
The thermostat（1）It is provided with and the heat insulation taper cock（2）The taper consent of cooperation（3）, the heat insulation taper cock
（2）By gland（4）Elastic compression is simultaneously maintained at taper consent（3）It is interior, the taper consent（3）Side is provided with three tunnels and is used for sample introduction
Level flows into duct（5）, the heat insulation taper cock（2）It is provided with and taper consent（3）Three tunnels described in flow into duct（5）Match somebody with somebody
He tri- flows into duct described in tunnel（5）, duct is flowed into described in three tunnels（5）Central axis pass through the heat insulation taper cock
（2）Axle center, flow into duct described in three tunnels（5）Level stops at heat insulation taper cock（2）Axle center and vertically vertically upward
Extend perforate, as outflow duct（6）, duct is flowed into described in three tunnels（5）Length it is identical, and the adjacent inflow duct（5）
Horizontal sextant angle it is identical.
A kind of 2. constant temperature sample introduction thermal insulation converging device according to claim 1, it is characterised in that the thermostat（1）By
Stainless steel material is made.
A kind of 3. constant temperature sample introduction thermal insulation converging device according to claim 1, it is characterised in that the thermostat（1）It is logical
Cross external semiconductor heating/refrigerating device and carry out temperature control and constant temperature.
A kind of 4. constant temperature sample introduction thermal insulation converging device according to claim 1, it is characterised in that the heat insulation taper rotation
Plug（2）By polytetrafluoroethylene (PTFE)（Hydrophilic modification）It is made.
5. a kind of constant temperature sample introduction thermal insulation converging device according to claim 1, can be operated in Three models, its feature exists
In by rotating the heat insulation taper cock（2）Switch over, the thermostat（1）The inflow duct（5）With it is described
Heat insulation taper cock（2）The inflow duct（5）It is respectively communicated with and flows into duct all the way（5）, two roads flow into duct（5）With three
Road flows into duct（5）, realize that single current enters single exit case, double fluid enters single exit case and three flow into single exit case.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710063803.5A CN107413403B (en) | 2017-02-04 | 2017-02-04 | Constant temperature sample introduction is insulated converging device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710063803.5A CN107413403B (en) | 2017-02-04 | 2017-02-04 | Constant temperature sample introduction is insulated converging device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107413403A true CN107413403A (en) | 2017-12-01 |
| CN107413403B CN107413403B (en) | 2019-11-29 |
Family
ID=60423108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710063803.5A Expired - Fee Related CN107413403B (en) | 2017-02-04 | 2017-02-04 | Constant temperature sample introduction is insulated converging device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107413403B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2169003Y (en) * | 1993-05-19 | 1994-06-15 | 石文星 | Mixing and distributing valve |
| CN2530112Y (en) * | 2002-04-05 | 2003-01-08 | 张云龙 | Three-position ball valve |
| CN1470788A (en) * | 2003-06-22 | 2004-01-28 | 曹鹤平 | Conical-core rotary multi-ported valve |
| CN1776273A (en) * | 2005-11-30 | 2006-05-24 | 叶葱 | Flow-selecting valve |
| JP2008298161A (en) * | 2007-05-31 | 2008-12-11 | Fuji Koki Corp | Mixing valve |
| CN204573195U (en) * | 2015-04-05 | 2015-08-19 | 氟络塞尔特种阀门(苏州)有限公司 | Many logical stopcocks |
| CN104879532A (en) * | 2015-05-21 | 2015-09-02 | 青岛大学 | Variable thermal stability volume sample valve |
-
2017
- 2017-02-04 CN CN201710063803.5A patent/CN107413403B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2169003Y (en) * | 1993-05-19 | 1994-06-15 | 石文星 | Mixing and distributing valve |
| CN2530112Y (en) * | 2002-04-05 | 2003-01-08 | 张云龙 | Three-position ball valve |
| CN1470788A (en) * | 2003-06-22 | 2004-01-28 | 曹鹤平 | Conical-core rotary multi-ported valve |
| CN1776273A (en) * | 2005-11-30 | 2006-05-24 | 叶葱 | Flow-selecting valve |
| JP2008298161A (en) * | 2007-05-31 | 2008-12-11 | Fuji Koki Corp | Mixing valve |
| CN204573195U (en) * | 2015-04-05 | 2015-08-19 | 氟络塞尔特种阀门(苏州)有限公司 | Many logical stopcocks |
| CN104879532A (en) * | 2015-05-21 | 2015-09-02 | 青岛大学 | Variable thermal stability volume sample valve |
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| Publication number | Publication date |
|---|---|
| CN107413403B (en) | 2019-11-29 |
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| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20191129 Termination date: 20210204 |