CN107413403B - Constant temperature sample introduction is insulated converging device - Google Patents
Constant temperature sample introduction is insulated converging device Download PDFInfo
- Publication number
- CN107413403B CN107413403B CN201710063803.5A CN201710063803A CN107413403B CN 107413403 B CN107413403 B CN 107413403B CN 201710063803 A CN201710063803 A CN 201710063803A CN 107413403 B CN107413403 B CN 107413403B
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- CN
- China
- Prior art keywords
- taper
- thermal insulation
- duct
- cock
- tunnels
- Prior art date
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- Expired - Fee Related
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/02—Water baths; Sand baths; Air baths
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
- B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1894—Cooling means; Cryo cooling
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention patent relates to the devices of a kind of combination constant temperature sample introduction and insulation interflow, are made of thermostat, the cock of thermal insulation taper and gland.The cock of thermal insulation taper is by gland elastic compression and is maintained in the taper consent of thermostat, taper consent and thermal insulation taper cock are provided with three tunnels for the horizontal inflow duct of sample introduction and flow out duct all the way, and the thermal insulation taper cock is provided with described in three tunnels of inflow duct cooperation described in three tunnels with taper consent and flows into duct.Compact overall structure, it is not easy to reveal, thermal stability is good, it can various modes sample introduction, realize that list flows into single exit case, double fluid enters single exit case and three inflow single exit cases, high degree of automation, adaptability are good, it can be applied to biochemical analysis, bioengineering and chemical synthesis, preparation field, being applied especially to live thermometric analysis and test has advantage.
Description
Technical field
The invention patent relates to a kind of sample introduction converging devices, especially combine constant temperature sample introduction and insulation converging device, can
It applies in the fields such as various biochemical analysis, bioengineering and chemical synthesis, preparation field and biosensor.
Background technique
The process flow of biochemistry is generally required to carry out multiple sample interflow and be mixed, and stationary temperature is to guarantee biochemistry
Reaction meets the necessary condition of technique requirement.
Thermometric analysis is suitable for most of biochemical reaction, not by the shadow of the sample properties such as color, muddiness and electrochemistry
It rings, and the testing principle of calorimetric method is simple, reliable, is increasingly becoming the fields such as food safety, environment, medicine and quickly detects and open
The important directions of hair.Currently, there are many flow path combinations and analysis mode (enrichment, detection integrated calorimetric formula biology for thermometric analysis
Sensor, ZL 200910126677.9；Based on the calorimetric biosensor of reversible immobilised enzymes, ZL
200910126676.4) it should be insulation, but diabatic process needed for constant temperature at interflow that, especially thermometric analysis, which requires sample introduction,
Contradiction is formd with the insulation requirements at sample introduction interflow, the simple scheme mixed using metal block interflow cannot meet the requirements (enzyme heat
Bioreactor sample introduction blender, ZL 201420054107.X).
Flow Injection Analysis theory shows that the length of flow path in analytical equipment is affected to analysis result, therefore analyzes stream
Road shortening is advantageous to analyzing, and considers as the heat-insulated of analytical equipment and connection, it is desirable that constant temperature sample introduction and the structure at insulation interflow are tight
It gathers and facilitates combination.
Summary of the invention
Present invention aim to address the defect of sample introduction interflow technology in existing biochemistry, provide a kind of combination constant temperature into
The device of sample and insulation interflow.
The technical solution adopted by the present invention to solve the technical problems is: constant temperature sample introduction be insulated converging device by thermostat,
The cock of thermal insulation taper and gland composition, the thermostat are provided with the taper consent with thermal insulation taper cock cooperation, institute
The cock of thermal insulation taper is stated by gland elastic compression and is maintained in taper consent, taper consent side be provided with three tunnels for into
The horizontal of sample flows into duct A, and the thermal insulation taper cock is provided with three of inflow duct A cooperation described in three tunnels with taper consent
Duct B is flowed into described in road, the central axis in inflow duct described in three tunnels passes through the axle center of the thermal insulation taper cock, three tunnels
Inflow duct B level stops at thermal insulation taper cock axle center and upwardly extends aperture along axially vertical, as tap hole
Road, the length of inflow duct B described in three tunnels is identical, and the adjacent horizontal sextant angle for flowing into duct B is identical.
The thermostat is made of high chemically inert metal material, preferably stainless steel.
The thermostat carries out temperature control and constant temperature by external heating/refrigerating device, and preferably semiconductor heating/refrigerating fills
It sets.
The thermal insulation taper cock is made of high chemically inert heat insulator, and preferably polytetrafluoroethylene (PTFE) is (hydrophilic
Change and be modified).
Further, it is switched over by rotating the thermal insulation taper cock, the inflow duct A of the thermostat
It is respectively communicated with the inflow duct B of the thermal insulation taper cock and flows into duct all the way, two roads flow into duct and three tunnels and flow
Enter duct, realizes that single inflow single exit case, double fluid enter single exit case and three and flow into single exit cases, sample introduction flows through the inflow hole of thermostat
By constant temperature when road A, then passes through the inflow duct B of the thermal insulation taper cock and converged by flow pass interflow
Collection outflow.
Further, pass through the taper consent of setting twinned structure, the thermal insulation taper cock, the inflow hole
Road and the gland are combined into one group of Measurement channel and reference channel respectively as measurement and reference, group, and be such as multiplied survey simultaneously
Channel and reference channel are measured, it can be achieved that sample introduction while multiple groups channel.
The invention has the advantages that realizing constant temperature sample introduction and insulation interflow, compact overall structure, drift ice quantity is short, cone
Shape face cooperation easily connection, is not easy to reveal, thermal stability is good；Thermostatic mode is flexible, can use semiconductor heating/refrigerating, water
The modes such as heating/refrigerating；It can be convenient combination, various modes sample introduction realizes that single inflow single exit case, double fluid enter single exit case and three streams
Enter single exit case, high degree of automation；Reference measurement may be implemented, what is obtained is difference component, eliminates nonspecific interference, reduces and misses
Difference, sample introduction while improving measurement accuracy and realize multiplexer channel；Adaptability is good, can be applied to biochemical analysis, bioengineering and
Chemical synthesis, preparation field, being applied especially to live thermometric analysis and test has advantage.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is the schematic diagram of the section structure of the invention.
Fig. 2 is overlooking structure diagram of the invention.
Fig. 3 is the structural schematic diagram of thermal insulation taper cock.
Fig. 4 is the schematic illustration that the cock of thermal insulation taper switches inflow and outflow mode counterclockwise.
Wherein: 1, thermostat, 2, thermal insulation taper cock, 3, taper consent, 4, gland, 5, inflow duct A, 5 ', inflow
Duct B, 6, outflow duct.
Specific embodiment
Present invention combination nationality by below in conjunction with embodiment illustrate the content of the present invention, the model being not intended to limit the present invention
It encloses.
As depicted in figs. 1 and 2, constant temperature sample introduction is insulated converging device by thermostat 1, thermal insulation taper cock 2 and 4 groups of gland
At thermostat 1 is polygon stainless steel metal block, and the bottom of thermostat 1 carries out temperature control simultaneously by semiconductor heating/refrigerating device
Constant temperature, thermostat 1 are provided with the taper consent 3 cooperated with thermal insulation taper cock 2, and thermal insulation taper cock 2 relies on bullet by gland 4
Spring force is compressed and is maintained in taper consent 3, and 2 top of thermal insulation taper cock is disposed with the protrusion of semicolumn hemicone, knot
For structure as shown in figure 3, being used to be inserted into the end socket of microresponse device entrance, guarantee runner is closed.3 side of taper consent is provided with three tunnels and is used for
The inflow duct A5 of sample introduction, thermal insulation taper cock 2 are provided with three roads for flowing into duct A5 cooperation with three tunnels of taper consent 3 and flow into
Duct B5 ', the central axis that three roads flow into duct B5 ' pass through the axle center of thermal insulation taper cock 2, and three roads flow into duct B5 '
Length it is identical, and adjacent inflow duct B5 ' horizontal sextant angle be 45 °, three roads flow into duct B5 ' level stop at thermal insulation taper
2 axle center of cock simultaneously upwardly extends aperture along axially vertical, as outflow duct 6.Thermal insulation taper cock 2 and gland 4 are by poly-
Tetrafluoroethene (hydrophilic modification) material is made.
As shown in figure 4, thermal insulation taper cock 2 rotates 45 ° and 90 ° of angle respectively counterclockwise, three tunnels of thermostat 1 are flowed into
Duct A5 flows into duct B5 with three tunnels of thermal insulation taper cock 2 and is connected to inflow duct, two tunnels inflow duct and three roads stream all the way
Enter duct, realizes that three inflows single exit case (Fig. 4 a), double fluid enter single exit case (Fig. 4 b) and single inflow single exit case (Fig. 4 c), sample introduction flows through
By constant temperature when the inflow duct A5 of thermostat 1, three roads for then passing through thermal insulation taper cock 2 flow into duct B5 ' and pass through stream
Outflow is collected at the interflow of channel 6 out.Thermal insulation taper cock 2, which rotates clockwise, can also realize that above-mentioned function, principle are consistent.
As depicted in figs. 1 and 2, by the way that the taper consent 2 of twinned structure is arranged, thermal insulation taper cock 3, gland 4, flows into
Duct A5, inflow duct B5 ' and outflow duct 6 are combined into one group of Measurement channel and reference channel respectively as measurement and reference, group.
Further, if be multiplied simultaneously Measurement channel and reference channel are, it can be achieved that sample introduction while multiple groups channel.
Claims (2)
1. a kind of constant temperature sample introduction is insulated converging device, it is made of thermostat, the cock of thermal insulation taper and gland, which is characterized in that
The thermostat (1) is provided with the taper consent (3) with the thermal insulation taper cock (2) cooperation, and the thermostat (1) is by stainless
Steel material is made, and the thermostat (1) carries out temperature control and constant temperature, the thermal insulation by external semiconductor heating/refrigerating device
Taper cock (2) is by gland (4) elastic compression and is maintained in taper consent (3), and the thermal insulation taper cock (2) is by hydrophilic
Change modified polytetrafluoroethylene (PTFE) to be made, taper consent (3) side of the thermostat (1) is provided with level of three tunnels for sample introduction
Flow into duct A(5), the thermal insulation taper cock (2) is provided with and flows into duct A(5 described in three tunnels of taper consent (3)) cooperation
Three tunnels described in inflow duct B(5 '), inflow duct B(5 ' described in three tunnels) central axis pass through the thermal insulation taper and revolve
The axle center for filling in (2), inflow duct B(5 ' described in three tunnels) level stops at thermal insulation taper cock (2) axle center and along axially vertical
Upwardly extend aperture, as outflow duct (6), inflow duct B(5 ' described in three tunnels) length it is identical, and the adjacent inflow hole
Road B(5 ') horizontal sextant angle it is identical.
2. a kind of constant temperature sample introduction according to claim 1 is insulated converging device, can work in Three models, feature exists
In being switched over by rotating the thermal insulation taper cock (2), the inflow duct A(5 of the thermostat (1)) and institute
State the inflow duct B(5 ' of thermal insulation taper cock (2)) it is respectively communicated with inflow duct, two tunnels inflow duct and three tunnels all the way
Duct is flowed into, realizes that single inflow single exit case, double fluid enter single exit case and three and flow into single exit cases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710063803.5A CN107413403B (en) | 2017-02-04 | 2017-02-04 | Constant temperature sample introduction is insulated converging device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710063803.5A CN107413403B (en) | 2017-02-04 | 2017-02-04 | Constant temperature sample introduction is insulated converging device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107413403A CN107413403A (en) | 2017-12-01 |
| CN107413403B true CN107413403B (en) | 2019-11-29 |
Family
ID=60423108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710063803.5A Expired - Fee Related CN107413403B (en) | 2017-02-04 | 2017-02-04 | Constant temperature sample introduction is insulated converging device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107413403B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2169003Y (en) * | 1993-05-19 | 1994-06-15 | 石文星 | Mixing and distributing valve |
| CN2530112Y (en) * | 2002-04-05 | 2003-01-08 | 张云龙 | Three-position ball valve |
| CN1470788A (en) * | 2003-06-22 | 2004-01-28 | 曹鹤平 | Conical-core rotary multi-ported valve |
| CN1776273A (en) * | 2005-11-30 | 2006-05-24 | 叶葱 | Flow-selecting valve |
| JP2008298161A (en) * | 2007-05-31 | 2008-12-11 | Fuji Koki Corp | Mixing valve |
| CN204573195U (en) * | 2015-04-05 | 2015-08-19 | 氟络塞尔特种阀门(苏州)有限公司 | Many logical stopcocks |
| CN104879532A (en) * | 2015-05-21 | 2015-09-02 | 青岛大学 | Variable thermal stability volume sample valve |
-
2017
- 2017-02-04 CN CN201710063803.5A patent/CN107413403B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2169003Y (en) * | 1993-05-19 | 1994-06-15 | 石文星 | Mixing and distributing valve |
| CN2530112Y (en) * | 2002-04-05 | 2003-01-08 | 张云龙 | Three-position ball valve |
| CN1470788A (en) * | 2003-06-22 | 2004-01-28 | 曹鹤平 | Conical-core rotary multi-ported valve |
| CN1776273A (en) * | 2005-11-30 | 2006-05-24 | 叶葱 | Flow-selecting valve |
| JP2008298161A (en) * | 2007-05-31 | 2008-12-11 | Fuji Koki Corp | Mixing valve |
| CN204573195U (en) * | 2015-04-05 | 2015-08-19 | 氟络塞尔特种阀门(苏州)有限公司 | Many logical stopcocks |
| CN104879532A (en) * | 2015-05-21 | 2015-09-02 | 青岛大学 | Variable thermal stability volume sample valve |
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| Publication number | Publication date |
|---|---|
| CN107413403A (en) | 2017-12-01 |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20191129 Termination date: 20210204 |