CN107412591A - One kind treats anginal medicine and preparation method thereof - Google Patents
One kind treats anginal medicine and preparation method thereof Download PDFInfo
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- CN107412591A CN107412591A CN201710454913.4A CN201710454913A CN107412591A CN 107412591 A CN107412591 A CN 107412591A CN 201710454913 A CN201710454913 A CN 201710454913A CN 107412591 A CN107412591 A CN 107412591A
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- 239000003814 drug Substances 0.000 title claims abstract description 48
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims description 14
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 34
- 240000003582 Platycodon grandiflorus Species 0.000 claims abstract description 34
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims abstract description 18
- 241000203379 Schefflera arboricola Species 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 18
- 240000005528 Arctium lappa Species 0.000 claims abstract description 17
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 17
- 241000471262 Ardisia japonica Species 0.000 claims abstract description 17
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 17
- 241001660870 Cyrtomium Species 0.000 claims abstract description 17
- 235000014066 European mistletoe Nutrition 0.000 claims abstract description 17
- 244000068988 Glycine max Species 0.000 claims abstract description 17
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 17
- 235000014676 Phragmites communis Nutrition 0.000 claims abstract description 17
- 235000012300 Rhipsalis cassutha Nutrition 0.000 claims abstract description 17
- 241000951473 Schizonepeta Species 0.000 claims abstract description 17
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims abstract description 17
- 239000009636 Huang Qi Substances 0.000 claims abstract description 16
- 240000008488 Thlaspi arvense Species 0.000 claims abstract description 16
- 235000008214 Thlaspi arvense Nutrition 0.000 claims abstract description 16
- 239000011248 coating agent Substances 0.000 claims abstract description 14
- 238000000576 coating method Methods 0.000 claims abstract description 14
- 244000088415 Raphanus sativus Species 0.000 claims abstract 5
- 244000152640 Rhipsalis cassutha Species 0.000 claims abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 47
- 239000000341 volatile oil Substances 0.000 claims description 40
- 239000000706 filtrate Substances 0.000 claims description 31
- 239000012188 paraffin wax Substances 0.000 claims description 24
- 239000006071 cream Substances 0.000 claims description 22
- 238000000605 extraction Methods 0.000 claims description 17
- 241000723353 Chrysanthemum Species 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 8
- 239000000853 adhesive Substances 0.000 claims description 8
- 230000001070 adhesive effect Effects 0.000 claims description 8
- 238000009833 condensation Methods 0.000 claims description 8
- 230000005494 condensation Effects 0.000 claims description 8
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 239000008101 lactose Substances 0.000 claims description 8
- 239000011777 magnesium Substances 0.000 claims description 8
- 229910052749 magnesium Inorganic materials 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 238000001256 steam distillation Methods 0.000 claims description 8
- 239000003643 water by type Substances 0.000 claims description 8
- 238000005516 engineering process Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 244000025254 Cannabis sativa Species 0.000 claims description 2
- 235000015067 sauces Nutrition 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 6
- 208000002193 Pain Diseases 0.000 abstract description 5
- 230000000857 drug effect Effects 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract description 2
- 239000008280 blood Substances 0.000 abstract description 2
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- 238000002474 experimental method Methods 0.000 abstract description 2
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract 1
- 241000220259 Raphanus Species 0.000 description 13
- 241000221012 Viscum Species 0.000 description 12
- 238000002386 leaching Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
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- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
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Abstract
The invention discloses one kind to treat anginal medicine, with 160~200 parts of mistletoe, 160~200 parts of folium callicarpae pedunculatae, 60~80 parts of schizonepeta, 80~100 parts of Fermented Soybean, 60~80 parts of thin,tough silk hair chrysanthemum, 100~120 parts of great burdock achene, 100~120 parts of reed rhizome, 100~120 parts of balloonflower root, 80~100 parts of spot village root, 0.5~1.5 part of notopterygium root, 100~110 parts of radish seed, 40~60 parts of field pennycress, 0.8~1.2 part of peppermint oil dementholized, 60~80 parts of folium isatidis, 70~90 parts of radix bupleuri, 70~90 parts of balloonflower root, 50~70 parts of the Radix Astragali, 40~60 parts of rhizome of cyrtomium, 40~60 parts of 30~60 parts of Japanese ardisia and schefflera arboricola, add appropriate amount of auxiliary materials and be made 1000, coating clothing produces.The invention also discloses the manufacture craft of the anginal medicine of the treatment, and by lot of experiments, each component drug effect of the present invention complements each other, and has the effect of promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, clearing and activating the channels and collaterals, can effectively treat angina pectoris.
Description
Technical field
The present invention relates to pharmaceutical field, specially one kind treats anginal medicine and preparation method thereof.
Background technology
Angina pectoris disease is to endanger the primary killers of human life and health, and at present, the medicine of patient with angina pectoris informal dress is more,
But conventional medicine has pills for curing heart disease, Danshen Tablets etc., although there is certain curative effect at that time, fundamentally can not effectively cure, no
It is always medical research problem that angina pectoris disease, which can thoroughly be cured, and patient with angina pectoris wishes that new treatment angina pectoris medicine comes out.
At present, western medicine angina pectoris is ineffective, and has more side effect, and therefore, people are to the rapid, effective treatment heart
Very big demand be present in the Chinese medicine of angina.
The content of the invention
The technical problem to be solved in the present invention is to overcome the defects of existing, there is provided a kind of anginal medicine of new treatment
Thing.
In order to solve the above-mentioned technical problem, the invention provides following technical scheme：
One kind treats anginal medicine, is made up of the medicine of following weight proportion：160~200 parts of mistletoe, folium callicarpae pedunculatae
160~200 parts, 60~80 parts of schizonepeta, 80~100 parts of Fermented Soybean, 60~80 parts of thin,tough silk hair chrysanthemum, 100~120 parts of great burdock achene, reed rhizome
100~120 parts, 100~120 parts of balloonflower root, 80~100 parts of spot village root, 0.5~1.5 part of notopterygium root, 100~110 parts of radish seed, lose
40~60 parts of sauce grass, 0.8~1.2 part of peppermint oil dementholized, 60~80 parts of folium isatidis, 70~90 parts of radix bupleuri, 70~90 parts of balloonflower root, the Radix Astragali
50~70 parts, 40~60 parts of rhizome of cyrtomium, 30~60 parts of Japanese ardisia, 40~60 parts of schefflera arboricola, add appropriate amount of auxiliary materials and be made 1000, bag
Film clothing produces.
Further, the anginal medicine of the novel therapeutic, it is made up of the medicine of following weight proportion：180 parts of mistletoe,
180 parts of folium callicarpae pedunculatae, 72 parts of schizonepeta, 90 parts of Fermented Soybean, 72 parts of thin,tough silk hair chrysanthemum, 108 parts of great burdock achene, 108 parts of reed rhizome, 108 parts of balloonflower root, spot
90 parts of village root, 1.05 parts of notopterygium root, 105 parts of radish seed, 49.5 parts of field pennycress, 1.1 parts of peppermint oil dementholized, 70 parts of folium isatidis, radix bupleuri 80
Part, 80 parts of balloonflower root, 60 parts of the Radix Astragali, 50 parts of rhizome of cyrtomium, 45 parts of Japanese ardisia, 50 parts of schefflera arboricola, add appropriate amount of auxiliary materials and be made 1000, bag
Film clothing produces.
The stability of anginal medicine in process of production, drug quality and drug effect are treated in order to improve, and
The term of validity of the anginal medicine of extended treatment, applicant are improved the preparation method for treating anginal medicine, preparation technology
Step is as follows：
1) 160~200 parts of folium callicarpae pedunculatae, 160~200 parts of mistletoe, 60~80 parts of schizonepeta is taken to be placed in volatile oil extractor,
8 times of waters are added, with extraction by steam distillation volatile oil, 4 hours is extracted, is layered after condensation, obtains volatile oil, it is standby；
2) by the dregs of a decoction and 80~100 parts of Fermented Soybean, 60~80 parts of thin,tough silk hair chrysanthemum, reed rhizome 100~120 after 1) extraction volatile oil
Part, 100~120 parts of balloonflower root, 80~100 parts of spot village root, 60~80 parts of folium isatidis, 70~90 parts of radix bupleuri, 70~90 parts of balloonflower root, Huang
12 50~70 parts of stilbene, 40~60 parts of rhizome of cyrtomium, 30~60 parts of Japanese ardisia, schefflera arboricola 40~60 part taste medicinal material mixing, add 10
1 hour is boiled in times decocting, and 8 times of decoctings are added after filtering and are boiled 1 hour, are filtered, merge filtrate twice；
3) 100~120 parts of use of great burdock achene, 60% ethanol heating and refluxing extraction is secondary, every time 4 hours, filtering, merges filter
Liquid, ethanol is reclaimed, adding paraffin makes dissolving, is cooled to paraffin and floats on liquid level, except paraffin layer；
4) filtrate obtained by merging 2) and 3) middle gained filtrate, are condensed into the leaching that relative density at 60 DEG C is 1.1~1.10
Cream, it is dried under reduced pressure, dried cream powder is made；
5), into dried cream powder, 1176 parts of lactose, 200 parts of talcum powder, 300 parts of sodium carboxymethyl starch, hard magnesium 30 are added
Part, it is that adhesive is pelletized with 95% ethanol；0.8~1.2 part of the volatile oil and peppermint oil dementholized of gained in adding 1), are mixed；
6) 0.5~1.5 part of notopterygium root, 100~110 parts of radish seed, 40~60 parts of field pennycress, mixing, tabletting, coating clothing are added
Produce.
Further, the step of preparation process for treating anginal medicine is as follows：
1) take 180 parts of folium callicarpae pedunculatae, 180 parts of mistletoe, 72 parts of schizonepeta to be placed in volatile oil extractor, add 8 times of waters, with
Extraction by steam distillation volatile oil, 4 hours are extracted, is layered after condensation, obtains volatile oil, it is standby；
2) will 1) extract 90 parts of the dregs of a decoction and Fermented Soybean after volatile oil, 72 parts of thin,tough silk hair chrysanthemum, 108 parts of reed rhizome, 108 parts of balloonflower root,
90 parts of spot village root, 70 parts of folium isatidis, 80 parts of radix bupleuri, 80 parts of balloonflower root, 60 parts of the Radix Astragali, 50 parts of rhizome of cyrtomium, 45 parts of Japanese ardisia, schefflera arboricola 50
Part, 12 taste medicinal material mixing, add 10 times of decoctings and boil 1 hour, 8 times of decoctings are added after filtering and are boiled 1 hour, are filtered, are closed
And filtrate twice；
3) 108 parts of use of great burdock achene, 60% ethanol heating and refluxing extraction is secondary, every time 4 hours, filtering, merging filtrate, returns
Ethanol is received, adding paraffin makes dissolving, is cooled to paraffin and floats on liquid level, except paraffin layer；
4) filtrate obtained by merging 2) and 3) middle gained filtrate, are condensed into the leaching that relative density at 60 DEG C is 1.1~1.10
Cream, it is dried under reduced pressure, dried cream powder is made；
5), into dried cream powder, 1176 parts of lactose, 200 parts of talcum powder, 300 parts of sodium carboxymethyl starch, hard magnesium 30 are added
Part, it is that adhesive is pelletized with 95% ethanol；1.1 parts of the volatile oil and peppermint oil dementholized of gained in adding 1), are mixed；
6) 1.05 parts of notopterygium root, 105 parts of radish seed, 49.5 parts of field pennycress, mixing are added, tabletting, coating clothing produces.
The anginal medicine for the treatment of of the present invention compared with prior art, has following beneficial effect：
Present invention applicant obtains the pharmaceutical formulation of scientific and reasonable treatment tumour, the present invention by lot of experiments
Each component drug effect complements each other, and has the effect of promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, clearing and activating the channels and collaterals, can effectively treat angina pectoris.
The anginal medicine for the treatment of of the present invention is on the premise of ensureing that curative effect of medication is basicly stable, in prescription, adds radix bupleuri, the spot village
The active ingredient of the medicinal materials such as root, schefflera arboricola, folium isatidis, the bad anti-of notopterygium root, radish seed and field pennycress can be taken with reduction of patient
Should, while the present invention improves and treats the stability of anginal medicine in process of production, drug quality and drug effect, Yi Jiyan
The long term of validity for treating anginal medicine.
Embodiment
The preferred embodiments of the present invention are illustrated below, it will be appreciated that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1
One kind treats anginal medicine, is made up of the medicine of following weight proportion：160 parts of mistletoe, folium callicarpae pedunculatae 160
Part, 60 parts of schizonepeta, 80 parts of Fermented Soybean, 60 parts of thin,tough silk hair chrysanthemum, 100 parts of great burdock achene, 100 parts of reed rhizome, 100 parts of balloonflower root, 80 parts of spot village root,
0.5 part of notopterygium root, 100 parts of radish seed, 40 parts of field pennycress, 0.8 part of peppermint oil dementholized, 80 parts of folium isatidis, 90 parts of radix bupleuri, 90 parts of balloonflower root,
70 parts of the Radix Astragali, 60 parts of rhizome of cyrtomium, 60 parts of Japanese ardisia, 60 parts of schefflera arboricola, add appropriate amount of auxiliary materials and be made 1000, coating clothing produces.
The step of preparation process that the formula treats anginal medicine is as follows：
1) take 160 parts of folium callicarpae pedunculatae, 160 parts of mistletoe, 60 parts of schizonepeta to be placed in volatile oil extractor, add 8 times of waters, with
Extraction by steam distillation volatile oil, 4 hours are extracted, is layered after condensation, obtains volatile oil, it is standby；
2) will 1) extract 80 parts of the dregs of a decoction and Fermented Soybean after volatile oil, 72 parts of thin,tough silk hair chrysanthemum, 100 parts of reed rhizome, 100 parts of balloonflower root,
80 parts of spot village root, 80 parts of folium isatidis, 90 parts of radix bupleuri, 90 parts of balloonflower root, 70 parts of the Radix Astragali, 60 parts of rhizome of cyrtomium, 60 parts of Japanese ardisia, schefflera arboricola 60
Part, 12 taste medicinal material mixing, add 10 times of decoctings and boil 1 hour, 8 times of decoctings are added after filtering and are boiled 1 hour, are filtered, are closed
And filtrate twice；
3) 100 parts of use of great burdock achene, 60% ethanol heating and refluxing extraction is secondary, every time 4 hours, filtering, merging filtrate, returns
Ethanol is received, adding paraffin makes dissolving, is cooled to paraffin and floats on liquid level, except paraffin layer；
4) filtrate obtained by merging 2) and 3) middle gained filtrate, are condensed into the leaching that relative density at 60 DEG C is 1.1~1.10
Cream, it is dried under reduced pressure, dried cream powder is made；
5), into dried cream powder, 1176 parts of lactose, 200 parts of talcum powder, 300 parts of sodium carboxymethyl starch, hard magnesium 30 are added
Part, it is that adhesive is pelletized with 95% ethanol；0.8 part of the volatile oil and peppermint oil dementholized of gained in adding 1), are mixed；
6) 0.5 part of notopterygium root, 100 parts of radish seed, 40 parts of field pennycress, mixing are added, tabletting, coating clothing produces.
Embodiment 2
One kind treats anginal medicine, is made up of the medicine of following weight proportion：200 parts of mistletoe, folium callicarpae pedunculatae 200
Part, 80 parts of schizonepeta, 100 parts of Fermented Soybean, 80 parts of thin,tough silk hair chrysanthemum, 120 parts of great burdock achene, 120 parts of reed rhizome, 120 parts of balloonflower root, spot village root 100
Part, 1.5 parts of notopterygium root, 110 parts of radish seed, 60 parts of field pennycress, 1.2 parts of peppermint oil dementholized, 60 parts of folium isatidis, 70 parts of radix bupleuri, balloonflower root 70
Part, 50 parts of the Radix Astragali, 40 parts of rhizome of cyrtomium, 30 parts of Japanese ardisia, 40 parts of schefflera arboricola, add appropriate amount of auxiliary materials and be made 1000, coating clothing produces.
The step of preparation process that the formula treats anginal medicine is as follows：
1) take 200 parts of folium callicarpae pedunculatae, 200 parts of mistletoe, 80 parts of schizonepeta to be placed in volatile oil extractor, add 8 times of waters, with
Extraction by steam distillation volatile oil, 4 hours are extracted, is layered after condensation, obtains volatile oil, it is standby；
2) will 1) extract 100 parts of the dregs of a decoction and Fermented Soybean after volatile oil, 80 parts of thin,tough silk hair chrysanthemum, 120 parts of reed rhizome, 120 parts of balloonflower root,
100 parts of spot village root, 60 parts of folium isatidis, 70 parts of radix bupleuri, 70 parts of balloonflower root, 50 parts of the Radix Astragali, 40 parts of rhizome of cyrtomium, 30 parts of Japanese ardisia, schefflera arboricola
40 parts, 12 taste medicinal material mixing, add 10 times of decoctings and boil 1 hour, 8 times of decoctings are added after filtering and are boiled 1 hour, are filtered,
Merge filtrate twice；
3) 120 parts of use of great burdock achene, 60% ethanol heating and refluxing extraction is secondary, every time 4 hours, filtering, merging filtrate, returns
Ethanol is received, adding paraffin makes dissolving, is cooled to paraffin and floats on liquid level, removes paraffin layer；
4) filtrate obtained by merging 2) and 3) middle gained filtrate, are condensed into the leaching that relative density at 60 DEG C is 1.1~1.10
Cream, it is dried under reduced pressure, dried cream powder is made；
5), into dried cream powder, 1176 parts of lactose, 200 parts of talcum powder, 300 parts of sodium carboxymethyl starch, hard magnesium 30 are added
Part, it is that adhesive is pelletized with 95% ethanol；0.8 part of the volatile oil and peppermint oil dementholized of gained in adding 1), are mixed；
6) 1.5 parts of notopterygium root, 110 parts of radish seed, 60 parts of field pennycress, mixing are added, tabletting, coating clothing produces.
Embodiment 3
One kind treats anginal medicine, is made up of the medicine of following weight proportion：180 parts of mistletoe, folium callicarpae pedunculatae 180
Part, 70 parts of schizonepeta, 90 parts of Fermented Soybean, 70 parts of thin,tough silk hair chrysanthemum, 110 parts of great burdock achene, 110 parts of reed rhizome, 110 parts of balloonflower root, 90 parts of spot village root,
1.0 parts of notopterygium root, 105 parts of radish seed, 50 parts of field pennycress, 1.0 parts of peppermint oil dementholized, 70 parts of folium isatidis, 80 parts of radix bupleuri, 80 parts of balloonflower root,
60 parts of the Radix Astragali, 50 parts of rhizome of cyrtomium, 45 parts of Japanese ardisia, 50 parts of schefflera arboricola, add appropriate amount of auxiliary materials and be made 1000, coating clothing produces.
The step of preparation process that the formula treats anginal medicine is as follows：
1) take 180 parts of folium callicarpae pedunculatae, 180 parts of mistletoe, 70 parts of schizonepeta to be placed in volatile oil extractor, add 8 times of waters, with
Extraction by steam distillation volatile oil, 4 hours are extracted, is layered after condensation, obtains volatile oil, it is standby；
2) will 1) extract 90 parts of the dregs of a decoction and Fermented Soybean after volatile oil, 70 parts of thin,tough silk hair chrysanthemum, 110 parts of reed rhizome, 110 parts of balloonflower root,
90 parts of spot village root, 70 parts of folium isatidis, 80 parts of radix bupleuri, 110 parts of balloonflower root, 60 parts of the Radix Astragali, 50 parts of rhizome of cyrtomium, 45 parts of Japanese ardisia, schefflera arboricola
50 parts, 12 taste medicinal material mixing, add 10 times of decoctings and boil 1 hour, 8 times of decoctings are added after filtering and are boiled 1 hour, are filtered,
Merge filtrate twice；
3) 110 parts of use of great burdock achene, 60% ethanol heating and refluxing extraction is secondary, every time 4 hours, filtering, merging filtrate, returns
Ethanol is received, adding paraffin makes dissolving, is cooled to paraffin and floats on liquid level, removes paraffin layer；
4) filtrate obtained by merging 2) and 3) middle gained filtrate, are condensed into the leaching that relative density at 60 DEG C is 1.1~1.10
Cream, it is dried under reduced pressure, dried cream powder is made；
5), into dried cream powder, 1176 parts of lactose, 200 parts of talcum powder, 300 parts of sodium carboxymethyl starch, hard magnesium 30 are added
Part, it is that adhesive is pelletized with 95% ethanol；0.8 part of the volatile oil and peppermint oil dementholized of gained in adding 1), are mixed；
6) 1 part of notopterygium root, 105 parts of radish seed, 50 parts of field pennycress, mixing are added, tabletting, coating clothing produces.
Embodiment 4
One kind treats anginal medicine, is made up of the medicine of following weight proportion：180 parts of mistletoe, folium callicarpae pedunculatae 180
Part, 72 parts of schizonepeta, 90 parts of Fermented Soybean, 72 parts of thin,tough silk hair chrysanthemum, 108 parts of great burdock achene, 108 parts of reed rhizome, 108 parts of balloonflower root, 90 parts of spot village root,
1.05 parts of notopterygium root, 105 parts of radish seed, 49.5 parts of field pennycress, 1.1 parts of peppermint oil dementholized, 70 parts of folium isatidis, 80 parts of radix bupleuri, balloonflower root 80
Part, 60 parts of the Radix Astragali, 50 parts of rhizome of cyrtomium, 45 parts of Japanese ardisia, 50 parts of schefflera arboricola, add appropriate amount of auxiliary materials and be made 1000, coating clothing produces.
The step of preparation process that the formula treats anginal medicine is as follows：
1) take 180 parts of folium callicarpae pedunculatae, 180 parts of mistletoe, 72 parts of schizonepeta to be placed in volatile oil extractor, add 8 times of waters, with
Extraction by steam distillation volatile oil, 4 hours are extracted, is layered after condensation, obtains volatile oil, it is standby；
2) will 1) extract 90 parts of the dregs of a decoction and Fermented Soybean after volatile oil, 72 parts of thin,tough silk hair chrysanthemum, 108 parts of reed rhizome, 108 parts of balloonflower root,
90 parts of spot village root, 70 parts of folium isatidis, 80 parts of radix bupleuri, 80 parts of balloonflower root, 60 parts of the Radix Astragali, 50 parts of rhizome of cyrtomium, 45 parts of Japanese ardisia, schefflera arboricola 50
Part, 12 taste medicinal material mixing, add 10 times of decoctings and boil 1 hour, 8 times of decoctings are added after filtering and are boiled 1 hour, are filtered, are closed
And filtrate twice；
3) 108 parts of use of great burdock achene, 60% ethanol heating and refluxing extraction is secondary, every time 4 hours, filtering, merging filtrate, returns
Ethanol is received, adding paraffin makes dissolving, is cooled to paraffin and floats on liquid level, except paraffin layer；
4) filtrate obtained by merging 2) and 3) middle gained filtrate, are condensed into the leaching that relative density at 60 DEG C is 1.1~1.10
Cream, it is dried under reduced pressure, dried cream powder is made；
5), into dried cream powder, 1176 parts of lactose, 200 parts of talcum powder, 300 parts of sodium carboxymethyl starch, hard magnesium 30 are added
Part, it is that adhesive is pelletized with 95% ethanol；1.1 parts of the volatile oil and peppermint oil dementholized of gained in adding 1), are mixed；
6) 1.05 parts of notopterygium root, 105 parts of radish seed, 49.5 parts of field pennycress, mixing are added, tabletting, coating clothing produces.
Accept patient 150 for medical treatment, man 80, female 70, the age between 40-70 years old, cures 137, effective 10, nothing
Effect 3, total effective rate is up to 98%.
Model case：
Case 1, Chen, female, 40 years old, symptom, the vexed pain person in anterior pectorial region, palpitaition is moved, and has hospital's color ultrasound, doppler diagnostic
And expert consultation.Take the present invention the anginal medicine for the treatment of after after 20 days, various symptoms all disappear, observe one week,
No relapse.
Case 2, Wu, man, 38 years old, symptom, the vexed pain person in anterior pectorial region, palpitaition was moved, and has hospital's color ultrasound, doppler diagnostic and
Expert consultation, take the present invention the anginal medicine for the treatment of after after 30 days, angina pectoris disappears substantially, then takes two
After it, further consultation, body recovery from illness, observe one week, no relapse.
Case 3, Lee, man, 68 years old, the vexed pain person in anterior pectorial region, palpitaition was moved, and has hospital's color ultrasound, doppler diagnostic and expert
The consultation of doctors.The anginal medicine for the treatment of of the present invention is taken, after 30 days, symptom mitigation, and continuous medication is discontinued two days later, is observed
One week, no relapse.
Finally it should be noted that：The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention,
Although the present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, it still may be used
To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic.
Within the spirit and principles of the invention, any modification, equivalent substitution and improvements made etc., it should be included in the present invention's
Within protection domain.
Claims (4)
1. one kind treats anginal medicine, it is made up of the medicine of following weight proportion：160~200 parts of mistletoe, folium callicarpae pedunculatae
160~200 parts, 60~80 parts of schizonepeta, 80~100 parts of Fermented Soybean, 60~80 parts of thin,tough silk hair chrysanthemum, 100~120 parts of great burdock achene, reed rhizome
100~120 parts, 100~120 parts of balloonflower root, 80~100 parts of spot village root, 0.5~1.5 part of notopterygium root, 100~110 parts of radish seed, lose
40~60 parts of sauce grass, 0.8~1.2 part of peppermint oil dementholized, 60~80 parts of folium isatidis, 70~90 parts of radix bupleuri, 70~90 parts of balloonflower root, the Radix Astragali
50~70 parts, 40~60 parts of rhizome of cyrtomium, 30~60 parts of Japanese ardisia, 40~60 parts of schefflera arboricola, add appropriate amount of auxiliary materials and be made 1000, bag
Film clothing produces.
2. one kind as claimed in claim 1 treats anginal medicine, it is made up of the medicine of following weight proportion：Mistletoe
180 parts, 180 parts of folium callicarpae pedunculatae, 72 parts of schizonepeta, 90 parts of Fermented Soybean, 72 parts of thin,tough silk hair chrysanthemum, 108 parts of great burdock achene, 108 parts of reed rhizome, balloonflower root
108 parts, 90 parts of spot village root, 1.05 parts of notopterygium root, 105 parts of radish seed, 49.5 parts of field pennycress, 1.1 parts of peppermint oil dementholized, folium isatidis 70
Part, 80 parts of radix bupleuri, 80 parts of balloonflower root, 60 parts of the Radix Astragali, 50 parts of rhizome of cyrtomium, 45 parts of Japanese ardisia, 50 parts of schefflera arboricola, add appropriate amount of auxiliary materials and be made
1000, coating clothing produces.
A kind of 3. preparation method for treating anginal medicine as claimed in claim 1 or 2, it is characterised in that preparation technology
Step is as follows：
1) take 160~200 parts of folium callicarpae pedunculatae, 160~200 parts of mistletoe, 60~80 parts of schizonepeta to be placed in volatile oil extractor, add
8 times of waters, with extraction by steam distillation volatile oil, 4 hours are extracted, is layered after condensation, obtains volatile oil, it is standby；
2) will 1) extract 80~100 parts of the dregs of a decoction and Fermented Soybean after volatile oil, 60~80 parts of thin,tough silk hair chrysanthemum, 100~120 parts of reed rhizome,
100~120 parts of balloonflower root, 80~100 parts of spot village root, 60~80 parts of folium isatidis, 70~90 parts of radix bupleuri, 70~90 parts of balloonflower root, the Radix Astragali
50~70 parts, 40~60 parts of rhizome of cyrtomium, 30~60 parts of Japanese ardisia, the mixing of 12 taste medicinal materials of schefflera arboricola 40~60 part, add 10 times
1 hour is boiled in decocting, and 8 times of decoctings are added after filtering and are boiled 1 hour, are filtered, merge filtrate twice；
3) 100~120 parts of use of great burdock achene, 60% ethanol heating and refluxing extraction is secondary, every time 4 hours, filtering, merging filtrate, returns
Ethanol is received, adding paraffin makes dissolving, is cooled to paraffin and floats on liquid level, except paraffin layer；
4) filtrate obtained by merging 2) and 3) middle gained filtrate, are condensed into the medicinal extract that relative density at 60 DEG C is 1.1~1.10, subtract
Press dry dry, dried cream powder is made；
5), into dried cream powder, 1176 parts of lactose, 200 parts of talcum powder, 300 parts of sodium carboxymethyl starch, 30 parts of hard magnesium are added,
It is that adhesive is pelletized with 95% ethanol；0.8~1.2 part of the volatile oil and peppermint oil dementholized of gained in adding 1), are mixed；
6) 40~60 parts of 0.5~1.5 part of notopterygium root, 100~110 parts of radish seed, field pennycress mixings are added, tabletting, coating clothing produces.
A kind of 4. preparation method for treating anginal medicine as claimed in claim 3, it is characterised in that step of preparation process
It is as follows：
1) take 180 parts of folium callicarpae pedunculatae, 180 parts of mistletoe, 72 parts of schizonepeta to be placed in volatile oil extractor, add 8 times of waters, steamed with water
Steam distillation method extracts volatile oil, extracts 4 hours, is layered after condensation, obtains volatile oil, standby；
2) by the dregs of a decoction after 1) extraction volatile oil and 90 parts of Fermented Soybean, 72 parts of thin,tough silk hair chrysanthemum, 108 parts of reed rhizome, 108 parts of balloonflower root, the spot village
90 parts of root, 70 parts of folium isatidis, 80 parts of radix bupleuri, 80 parts of balloonflower root, 60 parts of the Radix Astragali, 50 parts of rhizome of cyrtomium, 45 parts of Japanese ardisia, 50 parts of schefflera arboricola,
12 taste medicinal material mixing, add 10 times of decoctings and boil 1 hour, and 8 times of decoctings are added after filtering and are boiled 1 hour, are filtered, merge two
Secondary filtrate；
3) 108 parts of use of great burdock achene, 60% ethanol heating and refluxing extraction is secondary, every time 4 hours, filtering, merging filtrate, reclaims second
Alcohol, adding paraffin makes dissolving, is cooled to paraffin and floats on liquid level, except paraffin layer；
4) filtrate obtained by merging 2) and 3) middle gained filtrate, are condensed into the medicinal extract that relative density at 60 DEG C is 1.1~1.10, subtract
Press dry dry, dried cream powder is made；
5), into dried cream powder, 1176 parts of lactose, 200 parts of talcum powder, 300 parts of sodium carboxymethyl starch, 30 parts of hard magnesium are added,
It is that adhesive is pelletized with 95% ethanol；1.1 parts of the volatile oil and peppermint oil dementholized of gained in adding 1), are mixed；
6) 1.05 parts of notopterygium root, 105 parts of radish seed, 49.5 parts of field pennycress, mixing are added, tabletting, coating clothing produces.
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Application publication date: 20171201 |