CN107397919B - 用于治疗足癣的中药洗剂及其制备方法 - Google Patents

用于治疗足癣的中药洗剂及其制备方法 Download PDF

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CN107397919B
CN107397919B CN201710618742.4A CN201710618742A CN107397919B CN 107397919 B CN107397919 B CN 107397919B CN 201710618742 A CN201710618742 A CN 201710618742A CN 107397919 B CN107397919 B CN 107397919B
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栾连军
刘雪松
周浩
谈满良
郭贝贝
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Binhai Industrial Technology Research Institute of Zhejiang University
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Tianjin Zedatian Health Technology Co ltd
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Abstract

本发明涉及用于治疗足癣的中药洗剂及其制备方法，每剂洗剂由以下主要原料药物制成：白花蛇舌草20‑40g、金银花15‑30g、连翘15‑30g、蒲公英15‑30g、紫花地丁15‑30g、鱼腥草15‑30g；黄芩10‑20g、黄柏10‑20g、大黄10‑20g、苦参10‑20g、蛇床子10‑20g、防风10‑20g、皂角5‑10g、土茯苓5‑10g；丹参5‑10g、熟地黄5‑10g；五倍子5‑10g、白矾5‑10g、大蒜5‑10g、醋20‑40mL。本发明能达到抗菌消炎，治疗足癣的功效。

Description

用于治疗足癣的中药洗剂及其制备方法
技术领域
本发明涉及中药洗剂领域，具体涉及用于治疗足癣的中药洗剂及其制备方法。
背景技术
足癣(tineapedis)，又称脚气，香港脚，是发生于足跖部、趾间皮肤的皮肤癣菌感染，有时可延及到足跟及足背，表现为足趾缝、足底或足缘的小水疱、脱皮、红斑糜烂，也可表现为足底、足缘的角化、粗糙。因为人的足底和趾间没有皮脂腺，缺乏抑制皮肤丝状真菌的脂肪酸，生理防御机能较差，而这些部位的皮肤汗腺却很丰富，出汗比较多，加之空气流通性差、局部潮湿温暖，有利于丝状真菌的生长。
足癣的病原菌主要有皮肤丝真菌(皮肤癣菌)中的絮状表皮癣菌、红色毛癣菌和石膏样癣菌，白色念珠菌也可引起。足癣临床上分为三型：1汗疮型：足部尤其足底起水疮，或聚集成群或融合成大疮，疮壁较厚不易破，以后水疮吸收及干燥脱屑，自觉刺痒胀痛。此型中医称田螺疱。2趾间糜烂型：此型最常见，趾间因汗液浸渍而糜烂发白，常觉发痒而搔抓，破后露出红润面，常继发感染而引起淋巴管炎、丹毒或蜂窝织炎。由于走动时不断摩擦表皮脱落，露出鲜红色糜烂面；严重者趾缝间、趾腹与足底交界处皮肤均可累及，瘙痒剧烈，多发于第3、4、5趾缝间。常见于多汗者。3鳞屑角化型：足跖、足缘、足跟部皮肤脚趾增厚、粗糙、脱屑，鳞屑成片状或小点状，反复脱落，甚至全部足底的皮肤角质层增厚，足跟可有深的裂口，引起疼痛，甚至影响劳动和行路。
在我国，足癣的发病率很高。足癣还可通过接触传染给其他人。单纯足癣的治疗以外用药为主，足癣的急性期，糜烂渗液时忌用刺激性强的外用药，如水杨酸洗剂；有合并症时要先治疗合并症再治疗足癣。足癣糜烂渗液或继发感染者，可用3％硼酸溶液或0.1％需佛奴尔溶液清洗或湿敷；或者用3%硼酸溶液浸泡，然后选用联苯苄唑乳膏等抗真菌霜剂，严重时可以使用抗生素。但是西药副作用较大。
发明内容
本发明的目的是提供一种用于治疗足癣的中药洗剂，对多种类型的足癣均有较好的治疗效果。
为解决上述技术问题，本发明所采用的技术方案是：用于治疗足癣的中药洗剂，其特征在于，每剂洗剂由以下主要原料药物制成：
（1）君药：白花蛇舌草20-40g、金银花15-30g、连翘15-30g、蒲公英15-30g、紫花地丁15-30g、鱼腥草15-30g；
（2）臣药：黄芩10-20g、黄柏10-20g、大黄10-20g、苦参10-20g、蛇床子10-20g、防风10-20g、皂角5-10g、土茯苓5-10g；
（3）佐药：丹参5-10g、熟地黄5-10g；
（4）使药：五倍子5-10g、白矾5-10g、大蒜5-10g、醋20-40mL。
进一步地，每剂洗剂的佐药中还包括乌贼骨5-10g。
进一步地，每剂洗剂还包括高锰酸钾15-20g和复方水杨酸5-10g。
用于治疗足癣的中药洗剂的制备方法，包括以下步骤：
步骤一、按所述剂量取君药、臣药和使药中的丹参、熟地黄以及使药中的五倍子，加入以上所取药物总质量10倍的水，冷浸30-55分钟，武火煮沸，文火煎煮1小时，过滤得到滤液，残渣继续加水，加水量为以上所取药物总质量8倍，武火煎煮25-50分钟，过滤，合并滤液，浓缩液，浓缩至相对密度1.10-1.20；
步骤二、取所述剂量的大蒜捣碎得到蒜泥，加水5-10mL水，得到蒜泥稀释液；
步骤三、取所述剂量的白矾（如果有乌贼骨或/和高锰酸钾，则与白矾一起粉碎）用研钵粉碎，过100-150目筛；
步骤四、将步骤一到步骤三所得的原料药混合，加入所述剂量的醋（如果有复方水杨酸，则在此时加入），即制得洗剂样品；
步骤五、将步骤四所得的洗剂样品，加50-60度的水2000mL即得本发明的外用洗剂。
进一步地，步骤一中冷浸时长为35分钟。
进一步地，步骤三中药物粉碎后过120目筛。
本发明使用的药物的药性：
黄芩【性味与归经】苦，寒。归肺、胆、脾、大肠、小肠经。【功能与主治】清热燥湿，泻火解毒，止血，安胎。用于湿温、暑湿，胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安。【用法与用量】3～10g。
黄柏【性味与归经】苦，寒。归肾、膀胱经。【功能与主治】清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疽尿赤，带下阴痒，热淋涩痛，脚气痿躄，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹湿疮。盐黄柏滋阴降火。用于阴虚火旺，盗汗骨蒸。
大黄【性味与归经】苦，寒。归脾、胃、大肠、肝、心包经。【功能与主治】泻下攻积，清热泻火，凉血解毒，逐瘀通经，利湿退黄。用于实热积滞便秘，血热吐衄，目赤咽肿，痈肿疔疮，肠痈腹痛，瘀血经闭，产后瘀阻，跌打损伤，湿热痢疾，黄疸尿赤，淋证，水肿；外治烧烫伤。酒大黄善清上焦血分热毒，用于目赤咽肿、齿龈肿痛。熟大黄泻下力缓、泻火解毒，用于火毒疮疡。大黄炭凉血化瘀止血，用于血热有瘀出血症。【用法与用量】3～15g；用于泻下不宜久煎。外用适量，研末敷于患处。
金银花【性味与归经】甘，寒。归肺、心、胃经。【功能与主治】清热解毒，疏散风热。用于痈肿疔疮，喉痹，丹毒，热毒血痢，风热感冒，温病发热。【用法与用量】6～15g。
连翘【性味与归经】苦，微寒。归肺、心、小肠经。【功能与主治】清热解毒，消肿散结，疏散风热。用于痈疽，瘰疬，乳痈，丹毒，风热感冒，温病初起，温热入营，高热烦渴，神昏发斑，热淋涩痛。【用法与用量】6～15g。
蒲公英【性味与归经】苦、甘，寒。归肝、胃经。【功能与主治】清热解毒，消肿散结，利尿通淋。用于疔疮肿毒，乳痈，瘰疬，目赤，咽痛，肺痈，肠痈，湿热黄疸，热淋涩痛。【用法与用量】10～15g。
紫花地丁【性味与归经】苦、辛，寒。归心、肝经。【功能与主治】清热解毒，凉血消肿。用于疔疮肿毒，痈疽发背，丹毒，毒蛇咬伤。【用法与用量】15～30g。
鱼腥草【性味与归经】辛，微寒。归肺经。【功能与主治】清热解毒，消痈排脓，利尿通淋。用于肺痈吐脓，痰热喘咳，热痢，热淋，痈肿疮毒。【用法与用量】15～25g，不宜久煎；鲜品用量加倍，水煎或捣汁服。外用适量，捣敷或煎汤。
配伍关系及有益效果：本发明采用清热解毒的白花蛇舌草、金银花、连翘、蒲公英、紫花地丁、鱼腥草为君药，以黄芩、黄柏、大黄、苦参、蛇床子清热燥湿，防风、皂角、土茯苓、祛风除湿为臣药，佐以活血药丹参、补肝肾药熟地黄，配以收湿敛疮的五倍子、乌贼骨和白矾，杀菌的大蒜和醋，相互配伍协同增效，达到抗菌消炎，治疗足癣的功效。对于病情较为严重的，可以加入高锰酸钾和复方乙酰水杨酸增强收湿敛疮的功效。
具体实施方式
下面结合具体实施例对本发明做进一步详细的说明。
实施例1
用于治疗足癣的中药洗剂的制备方法，包括以下步骤：
步骤一、按重量称取黄柏17g、黄芩17g、大黄17g、白花蛇舌草34g、金银花22g、连翘22g、蒲公英22g、紫花地丁22g、鱼腥草22g、蛇床子17g、苦参17g、防风17g、皂角6g、五倍子6g、丹参6g、土茯苓6g、熟地黄6g；加以上药物总质量10倍的水，冷浸35分钟，武火煮沸，文火煎煮1小时，过滤得到滤液，残渣继续以上药物总质量加8倍的水，武火煎煮30分钟，过滤，合并滤液，浓缩液，浓缩至相对密度1.15；
步骤二、将大蒜6g捣碎得到蒜泥加8mL水，得到蒜泥稀释液；
步骤三、白矾17g用研钵粉碎，过120目筛；
步骤四、将步骤一到步骤三所得的原料药混合，加入25mL醋；
步骤五、将步骤四所得的样品，加50度的水2000mL即得本发明的外用泡脚液，将泡脚液分两次使用，每次泡脚30分钟。
实施例2
用于治疗足癣的中药洗剂的制备方法，包括以下步骤：
步骤一、按重量称取黄柏17g、黄芩17g、大黄17g、白花蛇舌草34g、金银花22g、连翘22g、蒲公英22g、紫花地丁22g、鱼腥草22g、蛇床子17g、苦参17g、防风17g、皂角6g、五倍子6g、丹参6g、土茯苓6g、熟地黄6g；加以上药物总质量10倍的水，冷浸35分钟，武火煮沸，文火煎煮1小时，过滤得到滤液，残渣继续以上药物总质量加8倍的水，武火煎煮30分钟，过滤，合并滤液，浓缩液，浓缩至相对密度1.15；
步骤二、将大蒜6g捣碎得到蒜泥加8mL水，得到蒜泥稀释液；
步骤三、乌贼骨6g、白矾17g用研钵粉碎，过120目筛；
步骤四、将步骤一到步骤三所得的原料药混合，加入25mL醋；
步骤五、将步骤四所得的样品，加50度的水2000mL即得本发明的外用泡脚液，将泡脚液分两次使用，每次泡脚30分钟。
实施例3
用于治疗足癣的中药洗剂的制备方法，包括以下步骤：
步骤一、按重量称取黄柏17g、黄芩17g、大黄17g、白花蛇舌草34g、金银花22g、连翘22g、蒲公英22g、紫花地丁22g、鱼腥草22g、蛇床子17g、苦参17g、防风17g、皂角6g、五倍子6g、丹参6g、土茯苓6g、熟地黄6g；加以上药物总质量10倍的水，冷浸35分钟，武火煮沸，文火煎煮1小时，过滤得到滤液，残渣继续以上药物总质量加8倍的水，武火煎煮30分钟，过滤，合并滤液，浓缩液，浓缩至相对密度1.15；
步骤二、将大蒜6g捣碎得到蒜泥加8mL水，得到蒜泥稀释液；
步骤三、高锰酸钾18g、白矾17g用研钵粉碎，过120目筛；
步骤四、将步骤一到步骤三所得的原料药混合，加入25mL醋和复方水杨酸6 g；
步骤五、将步骤四所得的样品，加50度的水2000mL即得本发明的外用泡脚液，将泡脚液分两次使用，每次泡脚30分钟。
实施例4
用于治疗足癣的中药洗剂的制备方法，包括以下步骤：
步骤一、按重量称取黄柏17g、黄芩17g、大黄17g、白花蛇舌草34g、金银花22g、连翘22g、蒲公英22g、紫花地丁22g、鱼腥草22g、蛇床子17g、苦参17g、防风17g、皂角6g、五倍子6g、丹参6g、土茯苓6g、熟地黄6g；加以上药物总质量10倍的水，冷浸35分钟，武火煮沸，文火煎煮1小时，过滤得到滤液，残渣继续以上药物总质量加8倍的水，武火煎煮30分钟，过滤，合并滤液，浓缩液，浓缩至相对密度1.15；
步骤二、将大蒜6g捣碎得到蒜泥加8mL水，得到蒜泥稀释液；
步骤三、乌贼骨6g、高锰酸钾18g、白矾17g用研钵粉碎，过120目筛；
步骤四、将步骤一到步骤三所得的原料药混合，加入25mL醋和复方水杨酸6 g；
步骤五、将步骤四所得的样品，加50度的水2000mL即得本发明的外用泡脚液，将泡脚液分两次使用，每次泡脚30分钟。
临床治疗效果如下表：
Figure DEST_PATH_IMAGE002
以便更好的阐述本发明，共收集不同年龄不同类型的临床足癣患者：汗疮型患者80例，趾间糜烂性患者80例，鳞屑角化型80例，均采用本发明实施例4作为外洗液，效果如下：
Figure DEST_PATH_IMAGE004
典型病例1：
张某，27岁，男，足底起水疮，疮壁较厚不易破，干燥脱屑，自觉刺痒胀痛。诊断为汗疮型足癣。采用本发明泡脚1个月后明显好转，2个月后治愈。
典型病例2：
李某，38岁，男，汗液浸渍趾间导致糜烂发白，常觉发痒而搔抓，破后露出红润面，走动时不断摩擦表皮脱落，露出鲜红色糜烂面。诊断为趾间糜烂型足癣。采用本发明泡脚1个月后明显好转，3个月后治愈。
典型病例3：
袁某，15岁，女，足跟部皮肤脚趾粗糙、脱屑，鳞屑成片状或小点状，反复脱落，足跟可有深的裂口。诊断为鳞屑角化型足癣。采用本发明泡脚1个月后明显好转，3个月后治愈。

Claims (4)

1.用于治疗足癣的中药洗剂，其特征在于，每剂洗剂由以下原料药物制成：
（1）君药：白花蛇舌草34g、金银花22g、连翘22g、蒲公英22g、紫花地丁22g、鱼腥草22g；
（2）臣药：黄芩17g、黄柏17g、大黄17g、苦参17g、蛇床子17g、防风17g、皂角6g、土茯苓6g；
（3）佐药：丹参6g、熟地黄6g、乌贼骨6g；
（4）使药：五倍子6g、白矾17g、大蒜6g、醋25mL。
2.用于治疗足癣的中药洗剂，其特征在于，每剂洗剂由以下原料药物制成：
（1）君药：白花蛇舌草34g、金银花22g、连翘22g、蒲公英22g、紫花地丁22g、鱼腥草22g；
（2）臣药：黄芩17g、黄柏17g、大黄17g、苦参17g、蛇床子17g、防风17g、皂角6g、土茯苓6g；
（3）佐药：丹参6g、熟地黄6g、乌贼骨6g；
（4）使药：五倍子6g、白矾17g、大蒜6g、醋25mL；
（5）高锰酸钾18g和复方水杨酸6g。
3.根据权利要求1所述的用于治疗足癣的中药洗剂的制备方法，其特征在于，包括以下步骤：
步骤一、按所述剂量取全部君药、全部臣药、两种佐药和一种使药，所述的两种佐药为丹参、熟地黄，所述的一种使药为五倍子，加入以上所取药物总质量10倍的水，冷浸35分钟，武火煮沸，文火煎煮1小时，过滤得到滤液，残渣继续加水，加水量为以上所取药物总质量8倍，武火煎煮25-50分钟，过滤，合并滤液，浓缩，浓缩至相对密度1.10-1.20；
步骤二、取所述剂量的大蒜捣碎得到蒜泥，加水5-10mL 水，得到蒜泥稀释液；
步骤三、取所述剂量的乌贼骨和白矾用研钵粉碎，过120目筛；
步骤四、将步骤一得到的浓缩物、步骤二得到的稀释液、步骤三得到的粉末混合，加入所述剂量的醋，即制得洗剂样品；
步骤五、将步骤四所得的洗剂样品，加50-60度的水2000 mL即得外用洗剂。
4.根据权利要求2所述的用于治疗足癣的中药洗剂的制备方法，其特征在于，包括以下步骤：
步骤一、按所述剂量取全部君药、全部臣药、两种佐药和一种使药，所述的两种佐药为丹参、熟地黄，所述的一种使药为五倍子，加入以上所取药物总质量10倍的水，冷浸35分钟，武火煮沸，文火煎煮1小时，过滤得到滤液，残渣继续加水，加水量为以上所取药物总质量8倍，武火煎煮25-50分钟，过滤，合并滤液，浓缩，浓缩至相对密度1.10-1.20；
步骤二、取所述剂量的大蒜捣碎得到蒜泥，加水5-10mL 水，得到蒜泥稀释液；
步骤三、取所述剂量的乌贼骨、白矾和高锰酸钾用研钵粉碎，过120目筛；
步骤四、将步骤一得到的浓缩物、步骤二得到的稀释液、步骤三得到的粉末混合，加入所述剂量的醋和复方水杨酸，即制得洗剂样品；
步骤五、将步骤四所得的洗剂样品，加50-60度的水2000 mL即得外用洗剂。
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