CN107375800A - A kind of preparation technology of cough syrup - Google Patents

A kind of preparation technology of cough syrup Download PDF

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Publication number
CN107375800A
CN107375800A CN201710663686.6A CN201710663686A CN107375800A CN 107375800 A CN107375800 A CN 107375800A CN 201710663686 A CN201710663686 A CN 201710663686A CN 107375800 A CN107375800 A CN 107375800A
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reactor
filtrate
preparation technology
cough syrup
distillate
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周海云
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a kind of preparation technology of cough syrup, comprise the following steps：S1：Solid Chinese medicine is processed into section or piece；S2：Solid Chinese medicine is ground into powder, produces mixture B；S3：Steam distillation twice is carried out to mixture B, distillate twice is collected, as mixes distillate, residue is filtered, collects filtrate and filter residue；S4：Filter residue is placed in another reactor, adds ethanol, heats condensing reflux, the ethanol in fluid drip device is added dropwise in reactor when reacting progress, reaction is filtered after terminating, and collects filtrate, as liquor B；S5：Filtrate A and liquor B are merged, concentration, produce mixing filtrate；S6：Take sucrose to be dissolved in water, add mixing distillate, mixing filtrate, oil of negundo chastetree and preservative, shake up, dispense, produce cough syrup.Preparation technology proposed by the present invention, the efficiency high of extraction, time are short, and the usage amount of extractant is small, and energy resource consumption is few, and production cost is low, are not easy generation precipitation.

Description

A kind of preparation technology of cough syrup
Technical field
The present invention relates to drug preparation technique field, more particularly to a kind of preparation technology of cough syrup.
Background technology
Archaeology evidence shows, is the important component of traditional medicine in past medical domain reasonable employment Chinese herbal medicine, The use that China records Chinese herbal medicine earliest can trace back to B.C. 2800.Over nearly 5000, Chinese medicine is used to treat various Disease, nowadays Chinese medicine have evolved into an independent industry.
Chinese medicine is that active ingredient therein is directly extracted from Chinese herbal medicine, integration of drinking and medicinal herbs, can be to the Small side effects of human body A variety of difficult and complicated cases are treated at all.But the traditional instructions of taking of Chinese medicine is that Chinese herbal medicines are decocted into decoction of medicinal ingredients jointly to take, decoct The process boiled is cumbersome, time loss is more, and the taste weight of Chinese medicine in itself in the decoction of medicinal ingredients decocted out, and mouthfeel is puckery, bitter.In order to more preferable Take Chinese medicine, the formulations such as capsule, syrup, tablet, granule are made in Chinese medicine by existing multiple pharmaceutical factories.
Syrup is because its agreeable to the taste sense is better than capsule, tablet and granule, so when consumer selects frequently as preferred agent Type, especially for children and the crowd for difficulty of taking medicine.Chinese traditional medicine syrup is because of its intrinsic side effect in the syrup of numerous kinds The umber one for the sales volume ranking list that small advantage occupies.But existing Chinese traditional medicine syrup still suffers from raw material availability in preparation process The problem of low, only part active ingredient is extracted in Chinese medicine material, and recovery rate is low, thus the price of Chinese traditional medicine syrup be higher than it is general Logical syrup.And Chinese traditional medicine syrup is in process of production because the processing of raw material is incomplete, in easily occurring after placing a period of time Medicine precipitates, and influences agreeable to the taste sense when syrup uses.
The content of the invention
The invention aims to solve shortcoming present in prior art, and a kind of preparation of the cough syrup proposed Technique.
A kind of preparation technology of cough syrup, comprises the following steps：
S1：Chinese medicine pre-treatment works, by dry Radix Isatidis, Japanese Flowering Fern Rhizome, chrysanthemum indicum, cordate houttuynia, lepidium seed, purple perilla Son, geranium wilfordii, ardisia japonica, the tuber of stemona and tussilago are placed in cutting machine the section shape for cutting into that length is below 1cm, as mixture A, then the Radix Astragali and ganoderma lucidum are cut into slices respectively, as astragalus mongholicus tablet and ganoderma lucidum slice, it is standby；
S2：Mixture A, astragalus mongholicus tablet and ganoderma lucidum slice are placed in pulverizer and are ground into herb powder jointly, then by traditional Chinese medicine powder End is placed in low temperature ultrasonic in Ultrasound Instrument and disperses 10~20min, produces mixture B；
S3：Mixture B is placed in the reactor with agitating device, while adds deionization for the first time into reactor Water, under air-proof condition, heating stirring, and first time distillate is collected, the amount of deionized water is down to addition in question response device When 50~60%, stop heating, when temperature is down to 35~45 DEG C, to reaction wherein second of addition deionized water, then close Under the conditions of envelope, heating stirring, and second of distillate is collected, merge first time distillate and second of distillate, as mix distillate, together When by the residue in reactor respectively through gauze, 1.2 μm of filter membranes and 0.45 μm of membrane filtration, collect and merging filtrate and filter Slag, the filtrate of collection is filtrate A；
S4：Filter residue is placed in another reactor with fluid drip device, while by filter operation in S3 steps Residue alcohol flushing on used gauze, 1.2 μm of filter membranes and 0.45 μm of filter membrane is into reactor, then into reactor Add ethanol to solid matter to be fully immersed in ethanol, while ethanol is added in fluid drip device, closing liquid instils The valve that device connects with reactor, 30~60min of condensing reflux is heated, fluid drip is opened when reaction is carried out to 10min The valve that device connects with reactor, the ethanol in fluid drip device is added dropwise in reactor, reaction is down to room after terminating Temperature, the material in reactor filter respectively through gauze, 1.2 μm of filter membranes and 0.45 μm of filter membrane, collect and merging filtrate, as filtrate B；
S5：Filtrate A and liquor B are merged, it is 1.10~1.13 to carry out being concentrated under reduced pressure into relative density after stirring, i.e., Filtrate must be mixed；
S6：Take sucrose to add water, Ultrasonic Heating dissolving, obtain aqueous sucrose solution, S3 steps are sequentially added into aqueous sucrose solution That is collected in rapid mixes mixing filtrate, oil of negundo chastetree and the preservative in distillate, S5 steps, shakes up, and dispenses, produces cough syrup.
Preferably, the powder diameter in the S2 steps is below 100 μm.
Preferably, the amount for adding deionized water in the S3 steps for the first time is 12~15 times of herb powder quality.
Preferably, the amount for adding deionized water in the S3 steps for the first time is 6~10 times of herb powder mass parts.
Preferably, the temperature heated in the S4 steps is 70~80 DEG C.
Preferably, the speed that the ethanol in the S4 steps in fluid drip device is added in reactor is 5~10ml/ min。
Preferably, the Radix Isatidis, Japanese Flowering Fern Rhizome, chrysanthemum indicum, cordate houttuynia, lepidium seed, perilla seed, geranium wilfordii, ardisia japonica, The mass ratio of the tuber of stemona, tussilago and sucrose is 20：10：4：20：6：6：20：10：6：6：10：1：26.
Preferably, the addition of the oil of negundo chastetree is to add 0.75ml per in 1487.5g solid Chinese medicines.
Preferably, the preservative is the mixture of sodium benzoate and nipagin esters, and the addition of preservative is solid The mass ratio of the 0.5% of Chinese medicine gross mass, wherein sodium benzoate and nipagin esters is 10：1.
Cough syrup preparation technology proposed by the present invention, pre-processed respectively according to the difference of the character of Chinese medicine, then altogether With powder of the particle diameter less than 100 μm is ground into, is advantageous to the extraction of active ingredient in each medicinal material, improves extraction efficiency, shortening carries The time is taken, and reduces the use of extractant, steam extraction twice is carried out to Chinese medicine, the volatile oil in Chinese medicine is total to vapor With distilling out, it is easy to the collection and extraction of volatile oil, then the effective component of fixed oil in Chinese medicine is extracted by ethanol, and And the usage amount of ethanol is adjusted during ethanol extraction according to the amount of Chinese medicine, while filled during ethanol extracts by fluid drip The amount that the ethanol being pre-loaded with ensures ethanol in reactor is put, ethanol is obtained usage amount while extraction efficiency is ensured and reaches Minimum value, the usage amount of extractant is saved, while also reduce energy-output ratio when concentrating, reduce production cost, preparing work Triple filter, i.e. gauze, 1.2 μm of filter membranes and 0.45 μm of membrane filtration are used in skill, can be effectively ensured big in Chinese medicine residue Influence of the particle to the rate of filtration, and solid residue is few in the filtrate after filtering, reduces finished product and is produced after long-time is placed The appearance of the phenomenon of raw precipitation.
Brief description of the drawings
Fig. 1 is structural representation provided by the invention.
Fig. 2 is partial structural diagram provided by the invention.
Embodiment
The present invention is made with reference to specific embodiment further to explain.
Embodiment one
A kind of preparation technology of cough syrup proposed by the present invention, comprises the following steps：
S1：Chinese medicine pre-treatment works, by dry Radix Isatidis 250g, Japanese Flowering Fern Rhizome 125g, chrysanthemum indicum 50g, cordate houttuynia 250g, lepidium seed 75g, perilla seed 75g, geranium wilfordii 250g, ardisia japonica 125g, tuber of stemona 75g and tussilago 75g are placed in cutting machine The section shape that length is below 1cm, as mixture A are cut into, then Radix Astragali 125g and ganoderma lucidum 12.5g are cut into slices respectively, is Huang Stilbene piece and ganoderma lucidum slice, it is standby；
S2：Mixture A, astragalus mongholicus tablet and ganoderma lucidum slice are placed in pulverizer and are ground into herb powder jointly, then by traditional Chinese medicine powder End is placed in low temperature ultrasonic in Ultrasound Instrument and disperses 10~20min, produces mixture B；
S3：Mixture B is placed in the reactor with agitating device, while adds deionization for the first time into reactor Water, addition is 12~15 times of herb powder quality, under air-proof condition, heating stirring, and first time distillate is collected, treat anti- When answering the amount of deionized water in device to be down to the 50~60% of addition, stop heating, when temperature is down to 35~45 DEG C, to reaction Wherein second of addition deionized water, addition is 6~10 times of herb powder mass parts, then under air-proof condition, heating stirring, And second of distillate is collected, merge first time distillate and second of distillate, as mix distillate, while by the residue in reactor Thing through gauze, 1.2 μm of filter membranes and 0.45 μm of membrane filtration, is collected respectively and merging filtrate and filter residue, the filtrate of collection is to filter Liquid A；
S4：Filter residue is placed in another reactor with fluid drip device, while by filter operation in S3 steps Residue alcohol flushing on used gauze, 1.2 μm of filter membranes and 0.45 μm of filter membrane is into reactor, then into reactor Add ethanol to solid matter to be fully immersed in ethanol, while ethanol is added in fluid drip device, closing liquid instils The valve that device connects with reactor, 30~60min of condensing reflux is heated at 70~80 DEG C, is beaten when reaction is carried out to 10min The valve that fluid drip device connects with reactor is opened, the ethanol in fluid drip device is dripped with 5~10ml/min speed Add in reactor, react and room temperature is down to after terminating, the material in reactor is through gauze, 1.2 μm of filter membranes and 0.45 μm of filter membrane point Do not filter, collect simultaneously merging filtrate, as liquor B；
S5：Filtrate A and liquor B are merged, it is 1.10~1.13 to carry out being concentrated under reduced pressure into relative density after stirring, i.e., Filtrate must be mixed；
S6：Take sucrose 325g to add water, Ultrasonic Heating dissolving, obtain aqueous sucrose solution, sequentially added into aqueous sucrose solution Mixing distillate, the mixing filtrate in S5 steps, oil of negundo chastetree 0.75ml, sodium benzoate 6.7g and the nipagin esters collected in S3 steps 0.67g, shake up, dispense, produce cough syrup.
Chinese medical extract in preparation technology and conventional Chinese medicine cough syrup preparation process to above-mentioned specific embodiment Recovery rate calculated, result of calculation is as follows：
Embodiment one Commercially available product
Recovery rate % 13.6 7.3
Result of calculation shows that the utilization rate of Chinese medicine material is high in cough syrup preparation process proposed by the present invention, carries Efficiency high is taken, and time loss is short.
As shown in Figure 1-2,
In above-mentioned S3 steps, described agitating device includes agitator 1, and charging aperture is provided with the top of agitator 11, there is arc-shaped depression portion 12 in the bottom of agitator, discharging opening 13 is connected with the lowest part of arc-shaped depression portion, in arc-shaped depression portion Provided with wheel rotor 2, the rotating shaft 3 being vertically arranged is provided with agitator, some puddlers 4, rotating shaft bag are connected with rotating shaft Axis body 31 and lower axis body 32 are included, the lower end of upper axis body is arranged with the first adapter sleeve 5, and the upper end of lower axis body is connected with the second connection Set 6, the lower end of the first adapter sleeve are provided with the first teeth of some even circumferentials distribution, are provided with the upper end of the second adapter sleeve some Second teeth of even circumferential distribution, the first teeth and the engagement connection of the second teeth, are provided with first annular in the lower end of upper axis body Groove 311, the first fastener 312 being equipped with and insert on the first adapter sleeve in described first annular groove, in lower axis body Upper end is provided with the second annular groove 321, the second fastening being equipped with and insert on the second adapter sleeve in the second described annular groove Part 322, connected between the first adapter sleeve and the second adapter sleeve by some connecting bolts 33.
Retaining ring 34 is arranged with the lower end of lower axis body, retaining ring is fixed on agitator inwall by some dowels 35, Bearing 36 is provided between the lower end of retaining ring and lower axis body, seal closure 37 is respectively equipped with the upper and lower ends of retaining ring.
Wheel rotor is fixed on dowel.
Some heating through holes are provided with the wall thickness of agitator 1, heating through hole is axially arranged along agitator 1 and circumference is equal Even distribution.
Heating rod is provided with heating through hole.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto, Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.

Claims (9)

1. a kind of preparation technology of cough syrup, it is characterised in that comprise the following steps：
S1：Chinese medicine pre-treatment works, by dry Radix Isatidis, Japanese Flowering Fern Rhizome, and chrysanthemum indicum, cordate houttuynia, lepidium seed, perilla seed, always Stork grass, ardisia japonica, the tuber of stemona and tussilago, which are placed in cutting machine, cuts into section shape of the length for below 1cm, as mixture A, then The Radix Astragali and ganoderma lucidum are cut into slices respectively, as astragalus mongholicus tablet and ganoderma lucidum slice, it is standby；
S2：Mixture A, astragalus mongholicus tablet and ganoderma lucidum slice are placed in pulverizer and are ground into herb powder jointly, then herb powder is put Low temperature ultrasonic disperses 10~20min in Ultrasound Instrument, produces mixture B；
S3：Mixture B is placed in the reactor with agitating device, while adds deionized water for the first time into reactor, Under air-proof condition, heating stirring, and collect first time distillate, in question response device the amount of deionized water be down to addition 50~ When 60%, stop heating, when temperature is down to 35~45 DEG C, to reaction wherein second of addition deionized water, then in sealing strip Under part, heating stirring, and second of distillate is collected, merge first time distillate and second of distillate, as mix distillate, simultaneously will Residue in reactor is collected simultaneously merging filtrate and filter residue, received respectively through gauze, 1.2 μm of filter membranes and 0.45 μm of membrane filtration The filtrate of collection is filtrate A；
S4：Filter residue is placed in another reactor with fluid drip device, while will be made in S3 steps in filter operation Residue alcohol flushing on gauze, 1.2 μm of filter membranes and 0.45 μm of filter membrane adds into reactor, then into reactor Ethanol to solid matter is fully immersed in ethanol, while ethanol is added in fluid drip device, closing liquid drop instillator The valve connected with reactor, 30~60min of condensing reflux is heated, fluid drip device is opened when reaction is carried out to 10min The valve connected with reactor, the ethanol in fluid drip device is added dropwise in reactor, reaction is down to room temperature after terminating, instead Answer the material in device to be filtered respectively through gauze, 1.2 μm of filter membranes and 0.45 μm of filter membrane, collect simultaneously merging filtrate, as liquor B；
S5：Filtrate A and liquor B are merged, it is 1.10~1.13 to carry out being concentrated under reduced pressure into relative density after stirring, and is produced mixed Close filtrate；
S6：Take sucrose to add water, Ultrasonic Heating dissolving, obtain aqueous sucrose solution, sequentially added into aqueous sucrose solution in S3 steps The mixing filtrate, oil of negundo chastetree and the preservative that mix in distillate, S5 steps of collection, shake up, and dispense, produce cough syrup.
A kind of 2. preparation technology of cough syrup according to claim 1, it is characterised in that the powder in the S2 steps Particle diameter is below 100 μm.
3. the preparation technology of a kind of cough syrup according to claim 1, it is characterised in that in the S3 steps for the first time The amount for adding deionized water is 12~15 times of herb powder quality.
4. the preparation technology of a kind of cough syrup according to claim 1, it is characterised in that in the S3 steps for the first time The amount for adding deionized water is 6~10 times of herb powder mass parts.
5. the preparation technology of a kind of cough syrup according to claim 1, it is characterised in that heated in the S4 steps Temperature is 70~80 DEG C.
6. the preparation technology of a kind of cough syrup according to claim 1, it is characterised in that liquid drips in the S4 steps The speed that ethanol in dispensing device is added in reactor is 5~10ml/min.
7. the preparation technology of a kind of cough syrup according to claim 1, it is characterised in that the Radix Isatidis, osmund are passed through Crowd, chrysanthemum indicum, cordate houttuynia, lepidium seed, perilla seed, geranium wilfordii, ardisia japonica, the mass ratio of the tuber of stemona, tussilago and sucrose is 20： 10：4：20：6：6：20：10：6：6：10：1：26.
A kind of 8. preparation technology of cough syrup according to claim 1, it is characterised in that the addition of the oil of negundo chastetree To add 0.75ml in every 1487.5g solids Chinese medicine.
9. the preparation technology of a kind of cough syrup according to claim 1, it is characterised in that the preservative is benzoic acid The mixture of sodium and nipagin esters, and the addition of preservative is the 0.5% of solid Chinese medicine gross mass, wherein sodium benzoate and Buddhist nun The mass ratio for mooring golden ester is 10：1.
CN201710663686.6A 2017-08-06 2017-08-06 A kind of preparation technology of cough syrup Pending CN107375800A (en)

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CN116139232A (en) * 2022-12-22 2023-05-23 江苏颐海药业有限责任公司 Chinese medicinal compound preparation for eliminating phlegm and relieving cough and preparation method thereof
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Application publication date: 20171124