CN107375690A

CN107375690A - A kind of turbid hypoglycemic of invigorating the spleenization dissipate and preparation method and application

Info

Publication number: CN107375690A
Application number: CN201710645167.7A
Authority: CN
Inventors: 雷枭; 王先艳; 张丽梅; 胡春燕; 牛彩琴; 任继刚
Original assignee: Affiliated Hospital of North Sichuan Medical College
Current assignee: Affiliated Hospital of North Sichuan Medical College
Priority date: 2017-08-01
Filing date: 2017-08-01
Publication date: 2017-11-24

Abstract

Dissipated the invention discloses a kind of turbid hypoglycemic of invigorating the spleenization and preparation method and application, belong to field of traditional Chinese.The turbid hypoglycemic Bales Off of invigorating the spleenization includes：80 120 parts of 80 300 parts of 240 360 parts of the Radix Astragali, the bighead atractylodes rhizome by weight, 80 120 parts of Chinese yam, 80 120 parts of the root of kudzu vine, 80 120 parts of the membrane of a chicken's gizzard, 80 120 parts of the red sage root, 80 120 parts of lotus leaf, 80 120 parts of rhizoma alismatis, 40 120 parts of the wind-weed, 80 120 parts of mulberry fruit, 80 120 parts of matrimony vine, 80 120 parts of rhizoma atractylodis, 80 120 parts of raw hawthorn, 80 120 parts of semen litchi, 80 120 parts of Poria cocos, 80 120 parts of the tuber of pinellia and sealwort.The present invention can reduce in human body fat and blood-sugar content, and it is convenient to take, curative effect is obvious.

Description

A kind of turbid hypoglycemic of invigorating the spleenization dissipate and preparation method and application

Technical field

The present invention relates to field of traditional Chinese, and in particular to a kind of turbid hypoglycemic of invigorating the spleenization dissipate and preparation method thereof.

Background technology

In recent years, fat, crowd's ratio of pathoglycemia raise year by year in Chinese population, especially fat and high blood glucose Crowd be even more occupy the overwhelming majority therein.Research finds, more than the 18 years old abnormal higher illness rate of resident's fat in China For 18.6%, and there is obvious rejuvenation trend.

Suffer from this, diabetes mellitus in China illness rate is 11.6%, and the patient of prediabetes is more up to 50.1%.Glycosuria More than 90% category diabetes B (T2DM) in patient, wherein more than 80% is overweight or fat.It is fat to have close connection with T2DM System, the probability of obese people having diabetes are far above non-obese crowd, BMI (body-mass index) >=24 T2DM trouble Sick rate be BMI 2.0 times of person below 24, the T2DM illness rates of BMI >=28 are BMI 3.0 times of person below 24.At present, Clinical treatment pure T2DM and the medicine of simple obesity and research are more but inadequate to endomorphy type T2DM attention rate, face Bed research needs further deeply.It is clinical so far still lack can hypoglycemic, and can loss of weight and economy, the less medicament of side effect or Treatment method.

The content of the invention

In order to solve the problems, such as that prior art is present, it is an object of the invention to provide a kind of turbid hypoglycemic of invigorating the spleenization dissipate and Its preparation method and application, can reduce in human body fat and blood-sugar content, and it is convenient to take, curative effect is obvious.

The technical scheme that the present invention solves above-mentioned technical problem is as follows：

A kind of turbid hypoglycemic of invigorating the spleenization dissipates, including：Radix Astragali 240-360 parts by weight, bighead atractylodes rhizome 80-300 parts, mountain Medicine 80-120 parts, root of kudzu vine 80-120 parts, the membrane of a chicken's gizzard 80-120 parts, red sage root 80-120 parts, lotus leaf 80-120 parts, rhizoma alismatis 80-120 Part, wind-weed 40-120 parts, mulberry fruit 80-120 parts, matrimony vine 80-120 parts, rhizoma atractylodis 80-120 parts, raw hawthorn 80-120 parts, semen litchi 80-120 parts, Poria cocos 80-120 parts, tuber of pinellia 80-120 parts and sealwort 80-120 parts.

The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, deficiency of spleen-QI and stomach-QI, and storage is good for weak, endogenous damp formation with fortune, then raw phlegm, Life is turbid, and phlegm is turbid to be condensed into the stasis of blood, so causing blood fat rise, obesity, then diabetes B is formed.The present invention with the Radix Astragali, the bighead atractylodes rhizome, Chinese yam is monarch, strengthening the spleen and replenishing qi.Spleen fortune is strong, and then water is wet, phlegm is turbid fugitive.Rhizoma atractylodis, Poria cocos invigorating spleen to remove dampness.The root of kudzu vine rises Tianjin and inspires temper It is up.The wind-weed rushes down clearly interior heat.The red sage root, semen litchi disperse blood stasis and dredge collateral dissipating bind.The tuber of pinellia, Poria cocos resolving sputum dampness removing.Hawthorn, the membrane of a chicken's gizzard disperse accumulations and Stomach, change fat.Lotus leaf is light clear up, scattered hot and suffocating, and makes to disperse the damp and hot of the part of the body cavity above the diaphragm housing the heart and lungs up to head in temper, and rhizoma alismatis is then gone down with dampness removing It is turbid to go out from urine.It is congenital to support that sealwort, matrimony vine, mulberry fruit are nourishing liver and kidney, and congenital abundance can then help the day after tomorrow.The invigorating the spleen of the present invention Change turbid hypoglycemic and dissipate all medicine phases 5, play strengthening the spleen and replenishing qi kidney tonifying altogether, expelling phlegm and resolving turbidity leads to the work(of the stasis of blood, help without love it is evil, remove heat by catharsis and Do not hinder just.

Further, in preferred embodiments of the present invention, the above-mentioned turbid hypoglycemic of invigorating the spleenization, which dissipates, also to be included：By weight Coptis 40-120 parts of meter.

The present invention further strengthens the effect of turbid hypoglycemic of invigorating the spleenization dissipates clearing heat-fire, Ke Yiyou by adding the coptis The vigorous obese patient of effect treatment internal heat.

Further, in preferred embodiments of the present invention, the above-mentioned turbid hypoglycemic Bales Off of invigorating the spleenization includes：By weight 300 parts of the Radix Astragali, 100 parts of the bighead atractylodes rhizome, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, 100 parts of lotus leaf, pool Rush down 100 parts, 50 parts of the coptis, 50 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, semen litchi 100 Part, 100 parts of Poria cocos, 100 parts of the tuber of pinellia and 100 parts of sealwort.

Further, in preferred embodiments of the present invention, the above-mentioned turbid hypoglycemic Bales Off of invigorating the spleenization includes：By weight 300 parts of the Radix Astragali, 100 parts of the bighead atractylodes rhizome, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, 100 parts of lotus leaf, pool Rush down 100 parts, coptis 100-120 parts, wind-weed 100-120 parts, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, raw hawthorn 100 Part, 100 parts of semen litchi, 100 parts of Poria cocos, 100 parts of the tuber of pinellia and 100 parts of sealwort.

The coptis, heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, internal heat are vomitted High Sheng, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache, quench one's thirst, carbuncle swells furunculosis；Eczema, wet sore are controlled outside, duct is suppurated.Prepared RHIZOMA COPTIDIS with vino It is burning hot to be apt to the clear part of the body cavity above the diaphragm housing the heart and lungs, for hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach anti-vomiting, mutually tied for fever and chills, damp and hot middle resistance, feeling of fullness vomiting. The easypro liver anti-vomiting of cornel coptis, for liver-stomach disharmony, vomits acid regurgitation.The wind-weed, clearing heat-fire, nourishing Yin and moistening dryness, matter profit cold in nature, there is cunning Intestines act on.Therefore, for the prosperous person of ferritic sun, the present invention is further appropriate in the turbid hypoglycemic of invigorating the spleenization dissipates to be increased the coptis and knows Female dosage, further enhance the turbid hypoglycemic of invigorating the spleenization and dissipate clearing heat and detoxicating, the effect of relaxing bowel, so as to ferritic Yang Wang Person can play more obvious therapeutic action.

Further, in preferred embodiments of the present invention, the bighead atractylodes rhizome is rhizoma atractylodis macrocephalae.

In the preferred scheme, specified mix " Radix Astragali 240-360 parts, bighead atractylodes rhizome 80-300 parts, Chinese yam 80-120 parts, the root of kudzu vine 80-120 parts, the membrane of a chicken's gizzard 80-120 parts, red sage root 80-120 parts, lotus leaf 80-120 parts, rhizoma alismatis 80-120 parts, coptis 40-120 parts, Wind-weed 40-120 parts, mulberry fruit 80-120 parts, matrimony vine 80-120 parts, rhizoma atractylodis 80-120 parts, raw hawthorn 80-120 parts, semen litchi 80- The bighead atractylodes rhizome in 120 parts, Poria cocos 80-120 parts, tuber of pinellia 80-120 parts and sealwort 80-120 part " is rhizoma atractylodis macrocephalae.Rhizoma atractylodis macrocephalae,《Medical science Qi Yuan》Described in arrive：" dehumidifying benefit is dry, and middle QI invigorating, middle benefit gas, goes wet in taste, except stomach energy, strong taste, enters diet, quenches the thirst, pacifies Tire." therefore, rhizoma atractylodis macrocephalae has a strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, it is antiabortive the effect of, for spleen eating less, abdominal distention diarrhea, phlegm Drink feel dizzy and heart palpitations, oedema, spontaneous perspiration, fetal irritability.Therefore, in the preferred scheme, the turbid hypoglycemic of this invigorating the spleenization of the invention dissipates, and makes More obvious therapeutic action can be played to diarrhoea person with rhizoma atractylodis macrocephalae.

Further, in preferred embodiments of the present invention, the above-mentioned turbid hypoglycemic of invigorating the spleenization, which dissipates, also to be included：By weight Dried immature fruit of citron orange 80-120 part and cassia seed 80-120 parts of meter, the bighead atractylodes rhizome are made a living the bighead atractylodes rhizome, and the content of the bighead atractylodes rhizome is 300 parts..

Constipation is often shown as：Awareness of defecation is few, and bowel frequency is also few；Defecation is difficult, laborious；Defecation is not smooth；Dry and hard excrement, it is hard just, row Just do not feel only；Constipation is with stomachache or abdominal discomfort.Some patientss are also with spirit such as insomnia, agitation, dreaminess, depression and anxiety Mental handicape.The effect of dried immature fruit of citron orange has a relieving stagnant Qi disperse accumulations, and resolving sputum dissipates ruffian, for treat product control in stop, feeling of fullness distending pain, weight after rush down dysentery, The illnesss such as constipation.Cassia seed, there is the effect of relaxing bowel, lipid-loweringing improving eyesight, for treating constipation and high fat of blood, high blood Pressure, has laxative, the effect of reducing blood pressure and blood fat.Therefore, for constipation person, the present invention is in " Radix Astragali 240-360 parts, bighead atractylodes rhizome 80- 300 parts, Chinese yam 80-120 parts, root of kudzu vine 80-120 parts, the membrane of a chicken's gizzard 80-120 parts, red sage root 80-120 parts, lotus leaf 80-120 parts, rhizoma alismatis 80-120 parts, coptis 40-120 parts, wind-weed 40-120 parts, mulberry fruit 80-120 parts, matrimony vine 80-120 parts, rhizoma atractylodis 80-120 parts, life The basis of hawthorn 80-120 parts, semen litchi 80-120 parts, Poria cocos 80-120 parts, tuber of pinellia 80-120 parts and sealwort 80-120 part " On, increase " dried immature fruit of citron orange 80-120 parts and cassia seed 80-120 parts ", can to constipation symptom obese diabetic patient or Person prolonged constipation person is effectively treated.Meanwhile in the formula, the bighead atractylodes rhizome is made a living the bighead atractylodes rhizome.

The raw bighead atractylodes rhizome, returns spleen, stomach are bitter, sweet and warm-natured；Can strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis is antiabortive.The raw bighead atractylodes rhizome with The dried immature fruit of citron orange and cassia seed coordinate, and can further strengthen therapeutic effect.

Further, in preferred embodiments of the present invention, the above-mentioned turbid hypoglycemic of invigorating the spleenization, which dissipates, also to be included：By weight Ligusticum wallichii 80-120 parts, reticulate millettia 80-120 parts and caulis lonicerae 80-120 part of meter.

Ligusticum wallichii：Promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Reticulate millettia：Promoting circulation of blood and enriching blood, it is clearing and activating the channels and collaterals, have and reduce blood pressure Effect.Caulis lonicerae：With clearing heat and detoxicating, the effect of dispelling wind dredging collateral.For limbs pain numbness person, the present invention is in " the Radix Astragali 240-360 parts, bighead atractylodes rhizome 80-300 parts, Chinese yam 80-120 parts, root of kudzu vine 80-120 parts, the membrane of a chicken's gizzard 80-120 parts, red sage root 80-120 parts, Lotus leaf 80-120 parts, rhizoma alismatis 80-120 parts, coptis 40-120 parts, wind-weed 40-120 parts, mulberry fruit 80-120 parts, matrimony vine 80-120 Part, rhizoma atractylodis 80-120 parts, raw hawthorn 80-120 parts, semen litchi 80-120 parts, Poria cocos 80-120 parts, tuber of pinellia 80-120 parts and sealwort It is appropriate to increase " Ligusticum wallichii 80-120 parts, reticulate millettia 80-120 parts and caulis lonicerae 80-120 parts " on the basis of 80-120 parts ", it is right Limbs pain numbness person can play more obvious therapeutic action.

Further, in preferred embodiments of the present invention, the above-mentioned turbid hypoglycemic of invigorating the spleenization, which dissipates, also to be included：By weight Tag 80-120 parts processed of meter.

In traditional Chinese medical science category, it is cold that innate deficiency of YANG in the body, aversion to cold and cold limbs person like drink intolerant to cold-evil, not.Therefore, the present invention is to being formulated into one Step optimization, in " Radix Astragali 240-360 parts, bighead atractylodes rhizome 80-300 parts, Chinese yam 80-120 parts, root of kudzu vine 80-120 parts, the membrane of a chicken's gizzard 80-120 Part, red sage root 80-120 parts, lotus leaf 80-120 parts, rhizoma alismatis 80-120 parts, wind-weed 40-120 parts, mulberry fruit 80-120 parts, matrimony vine 80- 120 parts, rhizoma atractylodis 80-120 parts, raw hawthorn 80-120 parts, semen litchi 80-120 parts, Poria cocos 80-120 parts, tuber of pinellia 80-120 parts and On the basis of sealwort 80-120 parts ", increase " tag 80-120 parts processed ", in order to which innate deficiency of YANG in the body, aversion to cold and cold limbs person use.System Tag, recuperating depleted yang, mends fire supporing yang, by wind-cold damp pathogen.In the preferred scheme, the turbid hypoglycemic of invigorating the spleenization of the invention dissipates not Addition can remove the cold coptis, then using big hot tag processed, innate deficiency of YANG in the body, aversion to cold and cold limbs person can be played more Obvious therapeutic action.

Further, in preferred embodiments of the present invention, the above-mentioned turbid hypoglycemic of invigorating the spleenization is dissipated for traditional Chinese powder medicine.

A kind of scattered preparation method of turbid hypoglycemic of invigorating the spleenization, including：Weigh Radix Astragali 240-360 parts, bighead atractylodes rhizome 80-300 parts, Chinese yam 80-120 parts, root of kudzu vine 80-120 parts, the membrane of a chicken's gizzard 80-120 parts, red sage root 80-120 parts, lotus leaf 80-120 parts, rhizoma alismatis 80-120 Part, wind-weed 40-120 parts, mulberry fruit 80-120 parts, matrimony vine 80-120 parts, rhizoma atractylodis 80-120 parts, raw hawthorn 80-120 parts, semen litchi 80-120 parts, Poria cocos 80-120 parts, tuber of pinellia 80-120 parts and sealwort 80-120 parts, mixed after crushing respectively, it is turbid that invigorating the spleenization is made Hypoglycemic dissipates.

Further, in preferred embodiments of the present invention, above-mentioned preparation method includes：Above-mentioned medicinal material is crushed respectively, Until then the herb in granule form of sieving is crushed again respectively again all by 40 mesh sieves per taste herb in granule form, until every Taste herb in granule form all by 80 mesh sieves, is mixed and produced.

Further, in preferred embodiments of the present invention, above-mentioned preparation method includes：Coptis 40-120 parts are crushed, Until herb in granule form all by 80 mesh sieves, then mixes with above-mentioned medicinal material.

Further, in preferred embodiments of the present invention, above-mentioned preparation method includes：The content of the coptis and the wind-weed is equal Improve to 100-120 parts, then crush respectively, until herb in granule form all by 80 mesh sieves, then mixes with above-mentioned medicinal material, make The turbid hypoglycemic of invigorating the spleenization that the prosperous person of ferritic sun must be directed to dissipates.

Further, in preferred embodiments of the present invention, above-mentioned preparation method includes：By dried immature fruit of citron orange 80-120 parts and Cassia Sub- 80-120 parts crush respectively, until herb in granule form all by 80 mesh sieves, then mixes with above-mentioned medicinal material, are made for long-term The turbid hypoglycemic of the invigorating the spleenization of constipation person dissipates.

Further, in preferred embodiments of the present invention, above-mentioned preparation method includes：By Ligusticum wallichii 80-120 parts, chicken blood Rattan 80-120 parts and caulis lonicerae 80-120 parts crush respectively, until herb in granule form is all by 80 mesh sieves, then with above-mentioned medicinal material Mixing, the turbid hypoglycemic of invigorating the spleenization being made for limbs pain numbness person dissipate.

Further, in preferred embodiments of the present invention, above-mentioned preparation method includes：Will tag 80-120 part powder processed It is broken, until herb in granule form all by 80 mesh sieves, then mixes with above-mentioned medicinal material, it is made for innate deficiency of YANG in the body, aversion to cold and cold limbs person The turbid hypoglycemic of invigorating the spleenization dissipate.Now, the coptis is not contained in formula.

The turbid hypoglycemic of invigorating the spleenization is dispersed in the application prepared in treatment diabetes B medicine.

Further, in preferred embodiments of the present invention, the turbid hypoglycemic of invigorating the spleenization is dissipated into collocation Metformin hydrochloride Use.

The invention has the advantages that：

The present invention is according to the basic TCM theory of diagnosis and treatment, there is provided Chinese medicine proportioning it is scientific and reasonable, medication is rigorous, real Test result to show, important formula provided by the invention is with good lipid-loweringing, blood sugar reducing function；For diabetes B and obesity The symptom of aspect has significant alleviation effect.

The preparation method of Chinese medicine preparation powder provided by the invention simultaneously, whole technological design is reasonable, each group obtained Divide active constituent content high, pharmacological activity is stronger, and impurity is few, and adverse reaction is low, and can be made into the powder for being convenient for carrying and using, Convenient to take, cost is cheap.

Embodiment

The principle and feature of the present invention are described with reference to embodiments, the given examples are served only to explain the present invention, It is not intended to limit the scope of the present invention.Unreceipted actual conditions person in embodiment, suggest according to normal condition or manufacturer Condition is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional products that can be obtained by commercially available purchase.

Embodiment 1：

The turbid hypoglycemic of the invigorating the spleenization of the present embodiment dissipates, including：

300 parts of the Radix Astragali, 100 parts of the bighead atractylodes rhizome, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 50 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, 100 parts of semen litchi, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort.

Embodiment 2：

240 parts of the Radix Astragali, 80 parts of the bighead atractylodes rhizome, 80 parts of Chinese yam, 80 parts of the root of kudzu vine, 80 parts of the membrane of a chicken's gizzard, 80 parts of the red sage root, 80 parts of lotus leaf, pool Rush down 80 parts, 40 parts of the wind-weed, 80 parts of mulberry fruit, 80 parts of matrimony vine, 80 parts of rhizoma atractylodis, 80 parts of raw hawthorn, 80 parts of semen litchi, 80 parts of Poria cocos, half 80 parts of summer, 80 parts of sealwort.

Embodiment 3：

360 parts of the Radix Astragali, 300 parts of the bighead atractylodes rhizome, 120 parts of Chinese yam, 120 parts of the root of kudzu vine, 120 parts of the membrane of a chicken's gizzard, 120 parts of the red sage root, lotus leaf 120 Part, 120 parts of rhizoma alismatis, 120 parts of the wind-weed, 120 parts of mulberry fruit, 120 parts of matrimony vine, 120 parts of rhizoma atractylodis, 120 parts of raw hawthorn, 120 parts of semen litchi, 120 parts of Poria cocos, 120 parts of the tuber of pinellia, 120 parts of sealwort.

Embodiment 4：

240 parts of the Radix Astragali, 80 parts of the bighead atractylodes rhizome, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 40 parts of the coptis, 40 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, lichee 100 parts of core, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort.

Embodiment 5：

360 parts of the Radix Astragali, 300 parts of the bighead atractylodes rhizome, 120 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 120 parts of the coptis, 120 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, litchi 100 parts of core of branch, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort.

Embodiment 6：

300 parts of the Radix Astragali, 100 parts of the bighead atractylodes rhizome, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 50 parts of the coptis, 50 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, lichee 100 parts of core, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort.

The scattered preparation method of the turbid hypoglycemic of the invigorating the spleenization of the present embodiment, including：

(1) medicinal material of above-mentioned formula is weighed, carries out crushing and processing respectively, and crosses 40 mesh sieves respectively and obtains sieving particle；Not By the component of screening crush and sieve again, until by screening, it is standby to obtain all sieving particles.

(2) the sieving particle obtained in step (1) is crushed again respectively, crosses 80 mesh sieves and obtain sieving particle；Not By the component of screening crush and sieve again, until by screening, it is standby to obtain all sieving particles.

(3) obtained particle in step (2) is mixed, invigorating the spleen is made first to grind after 80 mesh sieves in mixed method Change turbid hypoglycemic to dissipate.

Preferably, the obtained turbid hypoglycemic of invigorating the spleenization is dissipated for traditional Chinese powder medicine in the present embodiment.

Embodiment 7：

300 parts of the Radix Astragali, 100 parts of the bighead atractylodes rhizome, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 100 parts of the coptis, 100 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, litchi 100 parts of core of branch, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort.

The present embodiment and the difference of embodiment 6 are to increase to the content of the coptis and the wind-weed into 100 parts, are primarily adapted for use in The prosperous person of ferritic sun, can effectively treat thirsty, abscess of throat, swallow the symptoms such as discomfort.

The scattered preparation method of the turbid hypoglycemic of the invigorating the spleenization of the present embodiment is same as Example 6, and here is omitted.

Embodiment 8：

300 parts of the Radix Astragali, 100 parts of the bighead atractylodes rhizome, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 100 parts of tag processed, 50 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, 100 parts of semen litchi, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort.

The difference of the present embodiment and embodiment 6 is the coptis replacing with 100 parts of tag processed, is primarily adapted for use in ferritic sun Empty, aversion to cold and cold limbs person, the cold coptis is removed, then using big hot tag processed, it is played the effect of more obvious.

Embodiment 9：

240 parts of the Radix Astragali, 80 parts of the bighead atractylodes rhizome, 80 parts of Chinese yam, 80 parts of the root of kudzu vine, 80 parts of the membrane of a chicken's gizzard, 80 parts of the red sage root, 80 parts of lotus leaf, pool Rush down 80 parts, 80 parts of tag processed, 40 parts of the wind-weed, 80 parts of mulberry fruit, 80 parts of matrimony vine, 80 parts of rhizoma atractylodis, 80 parts of raw hawthorn, 80 parts of semen litchi, 80 parts of Poria cocos, 80 parts of the tuber of pinellia, 80 parts of sealwort.

Embodiment 10：

360 parts of the Radix Astragali, 300 parts of the bighead atractylodes rhizome, 120 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 120 parts of tag processed, 120 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, 100 parts of semen litchi, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort.

Embodiment 11：

300 parts of the Radix Astragali, 100 parts of rhizoma atractylodis macrocephalae, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 parts, 100 parts of rhizoma alismatis, 50 parts of the coptis, 50 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, 100 parts of semen litchi, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort.

The present embodiment and the difference of embodiment 6 are that it is rhizoma atractylodis macrocephalae to specify the bighead atractylodes rhizome, is primarily adapted for use in diarrhoea person.

Embodiment 12：

300 parts of the Radix Astragali, raw 300 parts of the bighead atractylodes rhizome, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 parts, 100 parts of rhizoma alismatis, 50 parts of the coptis, 50 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, 100 parts of semen litchi, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort, 100 parts of the dried immature fruit of citron orange, 100 parts of cassia seed.

The present embodiment and the difference of embodiment 6 be, the specified bighead atractylodes rhizome is made a living the bighead atractylodes rhizome, and increases by 100 parts of the dried immature fruit of citron orange and Cassia 100 parts of son, is primarily adapted for use in prolonged constipation person.

Embodiment 13：

240 parts of the Radix Astragali, 80 parts of the bighead atractylodes rhizome, 80 parts of Chinese yam, 80 parts of the root of kudzu vine, 80 parts of the membrane of a chicken's gizzard, 80 parts of the red sage root, 80 parts of lotus leaf, pool Rush down 80 parts, 40 parts of the coptis, 40 parts of the wind-weed, 80 parts of mulberry fruit, 80 parts of matrimony vine, 80 parts of rhizoma atractylodis, 80 parts of raw hawthorn, 80 parts of semen litchi, Fu 80 parts of Siberian cocklebur, 80 parts of the tuber of pinellia, 80 parts of sealwort, 80 parts of the dried immature fruit of citron orange, 80 parts of cassia seed.

Embodiment 14：

360 parts of the Radix Astragali, 300 parts of the bighead atractylodes rhizome, 120 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 120 parts of the coptis, 120 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, litchi 100 parts of core of branch, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort, 120 parts of the dried immature fruit of citron orange, 120 parts of cassia seed.

Embodiment 15：

300 parts of the Radix Astragali, 100 parts of the bighead atractylodes rhizome, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 50 parts of the coptis, 50 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, lichee 100 parts of core, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort, 100 parts of Ligusticum wallichii, 100 parts of reticulate millettia, 100 parts of caulis lonicerae.

The present embodiment and the difference of embodiment 6 are, add 100 parts of Ligusticum wallichii, 100 parts of reticulate millettia, 100 parts of caulis lonicerae, It is primarily adapted for use in limbs pain numbness person.

Embodiment 16：

240 parts of the Radix Astragali, 80 parts of the bighead atractylodes rhizome, 80 parts of Chinese yam, 80 parts of the root of kudzu vine, 80 parts of the membrane of a chicken's gizzard, 80 parts of the red sage root, 80 parts of lotus leaf, pool Rush down 80 parts, 40 parts of the coptis, 40 parts of the wind-weed, 80 parts of mulberry fruit, 80 parts of matrimony vine, 80 parts of rhizoma atractylodis, 80 parts of raw hawthorn, 80 parts of semen litchi, Fu 80 parts of Siberian cocklebur, 80 parts of the tuber of pinellia, 80 parts of sealwort, 80 parts of Ligusticum wallichii, 80 parts of reticulate millettia, 80 parts of caulis lonicerae.

Embodiment 17：

360 parts of the Radix Astragali, 300 parts of the bighead atractylodes rhizome, 120 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, 100 parts of the red sage root, lotus leaf 100 Part, 100 parts of rhizoma alismatis, 120 parts of the coptis, 120 parts of the wind-weed, 100 parts of mulberry fruit, 100 parts of matrimony vine, 100 parts of rhizoma atractylodis, 100 parts of raw hawthorn, litchi 100 parts of core of branch, 100 parts of Poria cocos, 100 parts of the tuber of pinellia, 100 parts of sealwort, 120 parts of Ligusticum wallichii, 120 parts of reticulate millettia, 120 parts of caulis lonicerae.

Test example

This test example is dissipated for experimental subjects with the turbid hypoglycemic of the invigorating the spleenization of embodiment 6, and the turbid hypoglycemic of invigorating the spleenization is dissipated The application effect of collocation Metformin hydrochloride illustrates.

First, testing program

In present case by the way of control experiment, control group and experimental group are set, under equal conditions carried out different Powder takes mode, counts the fasting blood-glucose of control group, experimental group before and after powder is taken respectively after a period of time is taken (FBG), 2h-plasma glucose (P2hBG), glycosylated hemoglobin (HbA1c), FPI (FINS), BMI, insulin resistance refer to The parameter indexs such as number (HOMA-IR), blood routine, liver kidney function, routine urine examination,urine for routine, stool for routine.In these indexs, HOMA-IR= (FINS × FPG)/22.5, when HOMA-IR ＞ 2.8 represent insulin resistance be present.

2nd, subjects

1st, control group：60,3 lost to follow-up in treatment, the person 2 that do not use according to regulations powder is remaining 55, male 25, Women 30；Average age (56.62 ± 9.89) year, average course of disease (4.80 ± 2.47) year.

2nd, experimental group：60, the person 4 that do not use according to regulations powder is remaining 56, male 30, women 26；It is average Year at age (56.61 ± 9.47), average course of disease (5.50 ± 3.70) year.

Control group and experimental group are by 120 patients for meeting inclusive criteria and to be randomly divided into reality using random number method Test group and control group, every group each 60.Thus it can be considered that it is same individual to participate in the control group of experiment and the individual of experimental group.

3rd, test method

For control group and the instructions of taking and dosage using traditional Chinese powder medicine of experimental group：

1st, control group：Oral melbine hydrocloride piece, first week each 0.25g, twice a day, takes immediately after the meal；The It is each 0.5g to start within two weeks to increase metformin dose, twice a day.

2nd, experimental group：Dissipated on the basis of control group plus with the turbid hypoglycemic of the invigorating the spleenization of embodiment 6, ampoule is taken This traditional Chinese powder medicine of 10g, it is placed in 150ml boiling water and is stirred, stands 20 minutes.Sooner or later respectively take once within 1 hour after meal.

The experiment course for the treatment of of control group and experimental group is 3 months, is not added with using insulin and other hypoglycemic medicines in the whole course for the treatment of.

4th, result of the test

Collection and statistical analysis for control group and experimental group experimental data, by melbine and the turbid drop of this invigorating the spleenization Sugared lipid-loweringing dissipates collocation using the experiment for realizing hypoglycemic, is acquired for the clinical data of wherein experimental subjects, passes through number According to change can analyze and show that the turbid hypoglycemic of this invigorating the spleenization dissipates application effect of the collocation melbine in hypoglycemic.Specifically Data are as follows：

Statistical analysis for component baseline characteristic, shown in detail by Tables 1 and 2.

1 two groups of patient population features of table

Note：Gender comparison uses Chi-square Test, and age, body weight are examined using sum of ranks Mann-Whitney U, height, the course of disease Using independent samples t-test, (P>0.05).

Table 2 two groups of patient baselines FBG, P2hBG, HbA1c, FINS, HOMA-IR, BMI compare

Note：BMI is examined using sum of ranks Mann-Whitney U, and remaining uses independent samples t-test, (P>0.05).

With reference to Tables 1 and 2, can unambiguously draw：Baseline characteristic harmony is good between two groups of experimental subjects groups, therefore Control experiment has comparativity.

Statistical analysis for two groups of hypoglycemic validity, shown in detail by table 3.

Hypoglycemic curative effect compares after 3 two groups of treatments of table

Note：Examined using sum of ranks Mann-Whitney U, (P ＜ 0.05).

Learnt by table 3, shown according to two groups of hypoglycemic efficacy results, effective 37 of 56 patients of experimental group, effective 13, Invalid 6, total effective rate 89.286%；Effective 23 of 55 patients of control group, effective 18, invalid 14, total effective rate 74.545%；Experimental group effective percentage is statistically significant (P ＜ 0.01) apparently higher than control group, difference after treating March.

Statistical analysis for two groups of lipid-loweringing validity, shown in detail by table 4.

Curative effect on obesity compares after 4 two groups of treatments of table

Note：Examined using sum of ranks Mann-Whitney U, (P ＜ 0.05).

Learnt by table 4, shown according to two groups of curative effect on obesity results, effective 35 of 56 patients of experimental group, effective 17, Invalid 4, total effective rate 92.857%；Effective 26 of 55 patients of control group, effective 16, invalid 13, total effective rate 76.364%；Experimental group effective percentage is statistically significant (P ＜ 0.05) apparently higher than control group, difference after treating March.

For two groups of pretherapy and post-treatment fasting blood-glucoses (FBG), 2h-plasma glucose (P2hBG), glycosylated hemoglobin (HbA1c), FPI (FINS), insulin resistance index (HOMA-IR), body mass index (BMI) situation of change, are entered by table 5 and table 6 Row displaying in detail.

The control group of table 5 pretherapy and post-treatment FBG, P2hBG, HbA1c, FINS, HOMA-IR, BMI are horizontal relatively

Note：P2hBG uses paired t-test, and remaining uses Wilcoxon signed rank sum tests (paired sample use) (P< 0.05)。

The experimental group of table 6 pretherapy and post-treatment FBG, P2hBG, HbA1c, FINS, HOMA-IR, BMI are horizontal relatively

Note：BMI uses Wilcoxon signed rank sum tests (paired sample use), and remaining uses paired t-test, (P< 0.05)。

According to table 5, table 6 it is known that two groups after treatment FBG, P2hBG, HbA1c, FINS, HOMA-IR, BMI have Decline, difference is statistically significant (P ＜ 0.01) compared with before the treatment of this group.

On the comparison of FBG, P2hBG, HbA1c, FINS, HOMA-IR, BMI value after two groups of treatments, carried out in detail by table 7 Thin displaying.

FBG, P2hBG, HbA1c, FINS, HOMA-IR, BMI are horizontal relatively after 7 two groups of treatments of table

Note：P2hBG uses independent samples t-test, and remaining is examined using sum of ranks Mann-Whitney U, (P ＜ 0.05).

Learnt by table 7, after treatment, experimental group FBG, P2hBG, HbA1c, FINS, HOMA-IR, BMI index reduce Obvious compared with control group, difference is statistically significant (P ＜ 0.01).

It can be proved by data above, dissipate collocation melbine in hypoglycemic using the turbid hypoglycemic of invigorating the spleenization of the present invention The positive effect of aspect carries out the effect of hypoglycemic better than melbine is used alone；And dissipated and taken using the turbid hypoglycemic of this invigorating the spleenization Positive effect with melbine in terms of lipid-loweringing is better than the effect that melbine progress lipid-loweringing is used alone.

Therefore, collocation melbine is dissipated in terms of hypoglycemic compared to exclusive use using the turbid hypoglycemic of this invigorating the spleenization Melbine has significantly more effect.

The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.

Claims

1. a kind of turbid hypoglycemic of invigorating the spleenization dissipates, it is characterised in that including：Radix Astragali 240-360 parts by weight, the bighead atractylodes rhizome 80-300 parts, Chinese yam 80-120 parts, root of kudzu vine 80-120 parts, the membrane of a chicken's gizzard 80-120 parts, red sage root 80-120 parts, lotus leaf 80-120 parts, Rhizoma alismatis 80-120 parts, wind-weed 40-120 parts, mulberry fruit 80-120 parts, matrimony vine 80-120 parts, rhizoma atractylodis 80-120 parts, raw hawthorn 80-120 Part, semen litchi 80-120 parts, Poria cocos 80-120 parts, tuber of pinellia 80-120 parts and sealwort 80-120 parts.

2. the turbid hypoglycemic of invigorating the spleenization according to claim 1 dissipates, it is characterised in that the turbid hypoglycemic of invigorating the spleenization dissipates Also include：Coptis 40-120 parts by weight.

3. the turbid hypoglycemic of invigorating the spleenization according to claim 2 dissipates, it is characterised in that the turbid hypoglycemic of invigorating the spleenization dissipates Including：100 parts of 300 parts of the Radix Astragali, the bighead atractylodes rhizome by weight, 100 parts of Chinese yam, 100 parts of the root of kudzu vine, 100 parts of the membrane of a chicken's gizzard, the red sage root 100 Part, 100 parts of lotus leaf, 100 parts of rhizoma alismatis, coptis 100-120 parts, wind-weed 100-120 parts, 100 parts of mulberry fruit, 100 parts of matrimony vine, rhizoma atractylodis 100 parts of 100 parts, 100 parts of raw hawthorn, 100 parts of semen litchi, 100 parts of Poria cocos, 100 parts of the tuber of pinellia and sealwort.

4. the turbid hypoglycemic of invigorating the spleenization according to claim 2 dissipates, it is characterised in that the bighead atractylodes rhizome is rhizoma atractylodis macrocephalae.

5. the turbid hypoglycemic of invigorating the spleenization according to claim 2 dissipates, it is characterised in that the turbid hypoglycemic of invigorating the spleenization dissipates Also include：Dried immature fruit of citron orange 80-120 parts and cassia seed 80-120 parts by weight, the bighead atractylodes rhizome are made a living the bighead atractylodes rhizome, and the content of the bighead atractylodes rhizome is 300 parts.

6. the turbid hypoglycemic of invigorating the spleenization according to claim 2 dissipates, it is characterised in that the turbid hypoglycemic of invigorating the spleenization dissipates Also include：Ligusticum wallichii 80-120 parts, reticulate millettia 80-120 parts and caulis lonicerae 80-120 parts by weight.

7. the turbid hypoglycemic of invigorating the spleenization according to claim 1 dissipates, it is characterised in that the turbid hypoglycemic of invigorating the spleenization dissipates Also include：Tag 80-120 parts processed by weight.

8. the preparation method that the turbid hypoglycemic of invigorating the spleenization described in claim any one of 1-7 dissipates, it is characterised in that including：Claim Take Radix Astragali 240-360 parts, bighead atractylodes rhizome 80-300 parts, Chinese yam 80-120 parts, root of kudzu vine 80-120 parts, the membrane of a chicken's gizzard 80-120 parts, red sage root 80- 120 parts, lotus leaf 80-120 parts, rhizoma alismatis 80-120 parts, wind-weed 40-120 parts, mulberry fruit 80-120 parts, matrimony vine 80-120 parts, rhizoma atractylodis 80-120 parts, raw hawthorn 80-120 parts, semen litchi 80-120 parts, Poria cocos 80-120 parts, tuber of pinellia 80-120 parts and sealwort 80-120 Part, mixed after crushing respectively, the turbid hypoglycemic of invigorating the spleenization is made and dissipates.

9. the turbid hypoglycemic of invigorating the spleenization described in claim any one of 1-7, which is dispersed in, prepares answering in treatment diabetes B medicine With.

10. application according to claim 9, it is characterised in that it is double that the turbid hypoglycemic of invigorating the spleenization is dissipated into collocation hydrochloride Guanidine uses.