CN107375491A - 一种用于治疗子宫内膜异位症的温经异痛舒中药复方及其制备方法 - Google Patents
一种用于治疗子宫内膜异位症的温经异痛舒中药复方及其制备方法 Download PDFInfo
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Abstract
本发明涉及中药技术领域，具体是一种用于治疗子宫内膜异位症的温经异痛舒中药复方及其制备方法。该中药复方由君药、臣药、佐药和使药组成，其中君药为炒白芍；臣药为炒延胡索、炒当归、制乳香、制没药；佐药为肉桂、吴茱萸、桂枝、茯苓；使药为甘草。本发明中药复方通过降低异位内膜的活性和浸润能力，使疾病由重转轻，并使患者痛经程度明显减轻，最终使子宫内膜异位症患者的痛经、月经不调、盆腔包块等临床症状消失，并能纠正内异症患者的血液淤滞状态，促进局部粘连及结缔组织的松解，加快淤血的吸收，从而抑制异位内膜的生长，达到治疗目的。
Description
技术领域
本发明涉及中药技术领域，具体是一种用于治疗子宫内膜异位症的温经异痛舒中药复方及其制备方法。
背景技术
子宫内膜异位症是指具有生长功能的子宫内膜腺体和间质出现在子宫腔被覆内膜及宫体肌层以外的其他部位，该病是激素依赖性疾病，临床表现多种多样，组织学上虽然是良性，但却有增生、浸润、转移及复发等恶性病理，是生育年龄妇女最常见的疾病之一。子宫内膜异位症的主要临床表现有盆腔疼痛、月经异常、不孕、巧囊等，这些症状及合并疾病都对育龄期妇女的身心健康造成了极大危害，是妇科常见的疑难病种。中国古代医学典籍中并没有对“子宫内膜异位症”的具体论述，但综合其临床表现可归为“痛经”、“不孕症”、“癥瘕”和“月经不调”等病的范畴之中。
子宫内膜异位症的治疗至今仍十分棘手，西医对子宫内膜异位症的治疗主要采用激素药物、手术治疗及放射治疗。激素类药物治疗虽能使痛经消失、经量减少、子宫内膜萎缩、子宫缩小，但使用激素衍生物抑制卵巢的功能，治疗费用较高，且有引起低雌激素症状、骨质疏松、肝功损害等副作用，停药后复发等弊端。对于药物无效的重症患者，需采用手术切除内膜异位病灶，甚至切除子宫、卵巢，从而达到治疗目的，但手术一般创伤大，复发率高，并不能根治，切除生殖器官令患者难以接受，年轻且有生育要求者更难以接受。放射治疗是通过光等破坏卵巢组织来消除卵巢激素的影响，使异位的内膜萎缩，达到治疗的目的，但这样会破坏卵巢的正常功能，影响女性的身体健康及正常生活。
中药医学在治疗该病时具有明显优势，相比于现代医学治疗方案，中药医学治疗副作用小，无需手术切除，且不破坏机体正常功能，患者接受性好。
发明内容
本发明的目的是提供一种能够有效治疗子宫内膜异位症的高效低毒的中药复方，本发明还提供了所述中药复方的制备方法。
为实现上述发目的，本发明采用以下技术方案：
一种用于治疗子宫内膜异位症的温经异痛舒中药复方，由君药、臣药、佐药和使药组成，君药为炒白芍；臣药为炒延胡索、炒当归、制乳香、制没药；佐药为肉桂、吴茱萸、桂枝、茯苓；使药为甘草。
上述用于治疗子宫内膜异位症的温经异痛舒中药复方，按重量份计配比如下：炒白芍30-40份、炒延胡索15-20份、炒当归15-20份、制乳香15-20份、制没药15-20份、肉桂8-10份、吴茱萸8-10份、桂枝8-10份、茯苓8-10份、甘草10份。
优选上述用于治疗子宫内膜异位症的温经异痛舒中药复方，按重量份计配比如下：炒白芍40份、炒延胡索20份、炒当归20份、制乳香20份、制没药20份、肉桂10份、吴茱萸10份、桂枝10份、茯苓10份、甘草10份。
上述用于治疗子宫内膜异位症的温经异痛舒中药复方可制成汤剂、散剂、水丸或颗粒剂。
优选上述用于治疗子宫内膜异位症的温经异痛舒中药复方为颗粒剂。
一种用于治疗子宫内膜异位症的温经异痛舒中药复方的制备方法，步骤如下：
(1)按配比秤取炒白芍、炒延胡索、炒当归、制乳香、制没药、肉桂、吴茱萸、桂枝、茯苓、甘草，干燥后研细混匀，得混合粉备用；
(2)将步骤(1)中得到的混合粉提取3次，第一次加10倍量的水，煎煮1h，第二次加8倍量的水，煎煮1h，第三次加6倍量水，煎煮0.5h，得提取液；对所得提取液进行浓缩，浓缩为浸膏粉；
(3)步骤(2)中得到的浸膏粉加辅料，并以80％乙醇为润湿剂，制成软材；
(4)将步骤(3)制成的软材，过20目筛制粒，置60℃烘箱内烘干24h后，混匀，整粒，分装，即得。
上述步骤(2)中浓缩的条件为60℃、0.09～0.1Mpa。
上述步骤(3)中辅料为糊精、可溶性淀粉和甜味素，且步骤(3)中浸膏粉与糊精、可溶性淀粉、甜味素按质量比1∶0.4∶0.1∶0.015混合。
上述用于治疗子宫内膜异位症的温经异痛舒中药复方在治疗子宫内膜异位症药物中的应用
本发明中药复方的使用方法：于月经前10天开始服用，连续服用10天，每日一剂(相当于含生药材170g)，分早晚2次冲服，连续3个月经周期，经期停服。
与现有技术相比，本发明的有益效果是：本发明中药复方的原料为纯天然植物药物，安全易得，方法简单易操作，不引入有毒物质，成本低廉，与现有技术比较，本发明中药复方通过降低异位内膜的活性和浸润能力，使疾病由重转轻，并使患者痛经程度明显减轻，最终使子宫内膜异位症患者的痛经、月经不调、盆腔包块等临床症状消失，并能纠正内异症患者的血液淤滞状态，促进局部粘连及结缔组织的松解，加快淤血的吸收，从而抑制异位内膜的生长，达到治疗目的。
具体实施方式
以下结合具体实施例对本发明做进一步说明。
实施例1
一种用于治疗子宫内膜异位症的温经异痛舒中药复方，由君药、臣药、佐药和使药组成，其中君药为炒白芍40克；臣药为炒延胡索20克、炒当归20克、制乳香20克、制没药20克；佐药为肉桂10克、吴茱萸10克、桂枝10克、茯苓10克；使药为甘草10克。
上述用于治疗子宫内膜异位症的温经异痛舒中药复方的制备方法，步骤如下：
(1)精选炒白芍、炒延胡索、炒当归、制乳香、制没药、肉桂、吴茱萸、桂枝、茯苓、甘草，各种药物干燥研细混匀备用；
(2)步骤(1)中的混合粉提取3次，第一次加10倍量水，煎煮1h，第二次加8倍量水，煎煮1h，第三次加6倍量水，煎煮0.5h，得提取液；提取液在60℃、0.1Mpa条件下减压浓缩得到浸膏粉；
(3)浸膏粉与糊精、可溶性淀粉、甜味素按质量比1∶0.4∶0.1∶0.015混合均匀，以80％乙醇为润湿剂，制成软材。
(4)将软材过20目筛制粒，置60℃烘箱内烘干24h后，混匀，整粒，分装，即得温经异痛舒中药复方颗粒。
实施例2
一种用于治疗子宫内膜异位症的温经异痛舒中药复方，由君药、臣药、佐药和使药组成，其中君药为炒白芍30克；臣药为炒延胡索15克、炒当归15克、制乳香15克、制没药15克；佐药为肉桂8克、吴茱萸8克、桂枝8克、茯苓10克；使药为甘草10克。
制备方法同实施例1。
实施例3
一种用于治疗子宫内膜异位症的温经异痛舒中药复方，由君药、臣药、佐药和使药组成，其中君药为炒白芍36克；臣药为炒延胡索17克、炒当归18克、制乳香17克、制没药17克；佐药为肉桂9克、吴茱萸98克、桂枝9克、茯苓9克；使药为甘草10克。
制备方法同实施例1。
药效学实验：
采用随机对照单盲的分组方法，分为治疗组和对照组，各15例，治疗组：给予实施例1温经异痛舒中药复方颗粒治疗。对照组给予安慰剂。两组于月经前10天开始服用，连续服用10天，每日一剂(相当于含生药材170g)，分早晚2次冲服，连续3个月经周期，经期停服。主要指标：痛经症状评分，痛经程度VAS评分；
表1两组患者痛经疗效
由表1可知，治疗组的疗法有效，可明显降低患者痛经的程度、改善痛经的相关症状。
表2超声检查盆腔包块治疗前后对比
由表2可知，经过t检验，治疗前后盆腔包块评分P值＜0.05，提示有统计学意义，表明实施例1温经异痛舒中药复方颗粒对于减小子宫内膜异位症盆腔包块效果明显。
由以上药效学实验可知，本发明的中药复方可明显降低患者痛经的程度，减小盆腔包块。
Claims (9)
1.一种用于治疗子宫内膜异位症的温经异痛舒中药复方，由君药、臣药、佐药和使药组成，其特征在于，君药为炒白芍；臣药为炒延胡索、炒当归、制乳香、制没药；佐药为肉桂、吴茱萸、桂枝、茯苓；使药为甘草。
2.如权利要求1所述的一种用于治疗子宫内膜异位症的温经异痛舒中药复方，其特征在于，所述中药复方按重量份计配比如下：炒白芍30-40份、炒延胡索15-20份、炒当归15-20份、制乳香15-20份、制没药15-20份、肉桂8-10份、吴茱萸8-10份、桂枝8-10份、茯苓8-10份、甘草10份。
3.如权利要求1所述的一种用于治疗子宫内膜异位症的温经异痛舒中药复方，其特征在于，所述中药复方按重量份计配比如下：炒白芍40份、炒延胡索20份、炒当归20份、制乳香20份、制没药20份、肉桂10份、吴茱萸10份、桂枝10份、茯苓10份、甘草10份。
4.如权利要求1所述的一种用于治疗子宫内膜异位症的温经异痛舒中药复方，其特征在于，所述中药复方可制成汤剂、散剂、水丸或颗粒剂。
5.如权利要求1所述的一种用于治疗子宫内膜异位症的温经异痛舒中药复方，其特征在于，所述中药复方为颗粒剂。
6.一种用于治疗子宫内膜异位症的温经异痛舒中药复方的制备方法，其特征在于，方法步骤如下：
(1)按配比秤取炒白芍、炒延胡索、炒当归、制乳香、制没药、肉桂、吴茱萸、桂枝、茯苓、甘草，干燥后研细混匀，得混合粉备用；
(2)将步骤(1)中得到的混合粉提取3次，第一次加10倍量的水，煎煮1h，第二次加8倍量的水，煎煮1h，第三次加6倍量水，煎煮0.5h，得提取液；对所得提取液进行浓缩，浓缩为浸膏粉；
(3)步骤(2)中得到的浸膏粉加辅料，并以80％乙醇为润湿剂，制成软材；
(4)将步骤(3)制成的软材，过20目筛制粒，置60℃烘箱内烘干24h后，混匀，整粒，分装，即得。
7.如权利要求6所述的一种用于治疗子宫内膜异位症的温经异痛舒中药复方的制备方法，其特征在于，步骤(2)中浓缩的条件为60℃、0.09～0.1Mpa。
8.如权利要求6所述的一种用于治疗子宫内膜异位症的温经异痛舒中药复方的制备方法，其特征在于，步骤(3)中辅料为糊精、可溶性淀粉和甜味素，且步骤(3)中浸膏粉与糊精、可溶性淀粉、甜味素按质量比1∶0.4∶0.1∶0.015混合。
9.权利要求1～4任一项所述的温经异痛舒中药复方在治疗子宫内膜异位症药物中的应用。
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