CN107375486A - Anti-inflammatory unstings is layered oil formula with compound - Google Patents
Anti-inflammatory unstings is layered oil formula with compound Download PDFInfo
- Publication number
- CN107375486A CN107375486A CN201710718641.4A CN201710718641A CN107375486A CN 107375486 A CN107375486 A CN 107375486A CN 201710718641 A CN201710718641 A CN 201710718641A CN 107375486 A CN107375486 A CN 107375486A
- Authority
- CN
- China
- Prior art keywords
- oil
- parts
- inflammatory
- agent
- lemon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Invention is related to a kind of anti-inflammatory for being used for injury gained in sports, the daily pain of injury etc. and unsting with compound layering oil formula, including each component of score ratio by weight：25 35 parts of levorotatory menthol, bata-carotene, vitamin E and atoleine；40 55 parts of narrow leaved tea tree, purple perilla, lopseed, needle juniper and the miscella of lemon；Totally 15 25 parts of denatured alcohol, deionized water and polyoxyethylene sorbitan monoleate.At present, the anti-inflammatory product that unstings is mostly western medicine composition, and long-term use has and has advantages below in contrast according to lazyness, the present invention by force：Using natural plant extraction volatile oil as raw material, the eliminating stasis to subdue swelling of affected part energy is applied to, anti-inflammatory, promoting blood circulation are unsting, effectively treat sportsman, the long-term wound such as the elderly, soldier, pull, pain of joint muscle, no medicine is according to lazyness, highly effective and safe, nursed available for athletic rehabilitation and joint；Volatile oil avoids the drug effect caused by volatile oil scatters and disappears from reducing in lower floor；Shake up emulsion, strengthen Transdermal absorption.
Description
Technical field
To be unsting the present invention relates to a kind of anti-inflammatory and be layered oil formula with compound, specifically external application is applied to patient's affected part,
With clearing heat and detoxicating, eliminating stasis to subdue swelling, anti-inflammation, invigorating blood circulation analgesia, wind-dispelling, dehumidifying and other effects, athletic injury, meaning can be effectively treated
Outer pull waits accidental injury and pain of joint muscle, it can also be used to which sports health, joint are nursed.
Anti-inflammatory unstings to be had with compound layering oil formula（A）、（B）With（C）Three kinds of components are formed.（A）Agent is used to be overcritical
β-carrot that the levorotatory menthol and microwave-assisted that carbon dioxide extracts from natural peppermint extract from the fruit of Chinese wolfberry
Element, vitamin E and atoleine；（B）Composition in agent is the solvent way of distillation from narrow leaved tea tree branches and leaves that are fresh or drying
The titrol of extraction, the perilla herb oil that supercritical fluid extraction extracts from perilla seed, ultrasound-enhanced supercritical CO2 extractions
The cade oil extracted from needle juniper cone is followed the example of, the lopseed oil that ultrasound-enhanced supercritical CO2 extractions extract from lopseed,
The lemon oil extracted using cold grinding filtration method from lemon；（C）Water used is the deionization after high-temperature sterilization sterilization processing in agent
Pure water, denatured alcohol and process are tested repeatedly, have been screened efficiently, safety, do not stimulate the Tween-80 of skin.
Because Tween-80 is a kind of surfactant, and contain multiple hydroxyls in molecule（—OH）With ether chain（-O-）
Group, align alcohol water blend with（A）、（B）Oil-water system for being formed of miscella in, denatured alcohol and poly- mountain
The amount of pear ester -80 determines whether the preparation of layering oil succeeds, and determines whether layering oil can timely and effectively be divided into after mixing
Upper and lower two layers of transparency liquid.Because two layers above and below layering oil, upper strata is alcohol water blend, and lower floor is active ingredient, is avoided that
In storage process because the active ingredients such as volatile oil volatilization scatter and disappear caused by drug effect reduce, and shake up emulsion, enhance
Transdermal absorption.
Background technology
At present, as this kind of plants essential oil such as narrow leaved tea tree, purple perilla, lopseed, needle juniper, lemon, China are also producing, year
Tens thousand of tons are produced, are mainly used in exporting, applicable surface is not wide, rarely has the product that added value is high.And the domestic anti-inflammatory product that unstings is mostly
Western medicine composition, long-term use have it is very strong according to lazyness, anti-inflammatory unsting with compound be layered oil using natural plant extraction volatile oil as
Raw material, can be long-term use of, will not produce medicine according to lazyness；This research project, opened up for the research and application of natural volatile oil
One new field.
Because this research project with 6 kinds has clearing heat and detoxicating, eliminating stasis to subdue swelling, anti-inflammation, invigorating blood circulation analgesia, wind-dispelling, dehumidifying
Natural plant extraction volatile oil be functional raw material, be aided with vitamin E, beta carotene, alcohol, deionized water and poly- sorb
Ester -80 makees base-material so that natural volatile oil component efficient, safety can act on affected part；It is particularly suitable for sportsman, the elderly,
The long-term wound such as soldier, is pulled, pain of joint muscle, and no medicine is strong according to lazyness, permeability；Raw material is cheap, efficient, safe,
Succeeding in developing for it will make new contribution for athletic injury, the unexpected treatment for the accidental injury such as pulling, and can also be used to treat
Pain of joint muscle.Meanwhile anti-inflammatory unstings and has played Chinese medicine in the side such as national athletic rehabilitation with the application of compound layering oil formula
The characteristic effect in face, sport and body-building, the essential product of joint nursing will be turned into.
The content of the invention
Pulled it is an object of the invention to provide one kind for human muscle, injury gained in sports, the anti-inflammatory of joint nursing for treating
Unsting and be layered oil formula with compound.Its major technique be used containing anti-inflammation, antiviral, promoting blood circulation and stopping pain isoreactivity into
Point, can be effectively clearing heat and detoxicating, eliminating stasis to subdue swelling, anti-inflammation, analgesia, wind-dispelling, dehumidifying, what is stimulated circulation does not produce drug resistance
Pure plant extraction volatile oil, make use of multiple hydroxyls of Tween-80（—OH）With ether chain（-O-）Group water-oil
Compound layering oil obtained by the proportioning of effect in system, preferably ethanol and Tween-80.
The purpose of the present invention realizes that anti-inflammatory, which unstings with compound layering oil formula, is matched somebody with somebody by following weight in the following manner
The raw material of ratio is made：Levorotatory menthol, beta carotene, vitamin E and atoleine mixed solution 25-35 parts；Mutual leaf white thousand
Layer, purple perilla, lopseed, needle juniper and 6 kinds of miscella 40-55 parts of lemon;Denatured alcohol, deionized water and Tween-80 are total to
Count 15-25 parts.
Preparation method is as follows：1. menthol is extracted from natural peppermint using supercritical carbon dioxide, through distilling crystallisation
Separate to obtain levorotatory menthol；2. beta carotene is extracted from the fruit of Chinese wolfberry using microwave-assisted；3. use the solvent way of distillation
Titrol is extracted from narrow leaved tea tree branches and leaves that are fresh or drying；4. it will be faced after perilla seed drying, crushing using super
Boundary's fluids extraction extraction perilla herb oil；5. cade oil is extracted from needle juniper cone using ultrasound-enhanced supercritical CO2 extractions；⑥
Lopseed oil is extracted from lopseed using ultrasound-enhanced supercritical CO2 extractions；7. carried using cool-milling extraction method from lemon
Take lemon oil.
1. it obtained levorotatory menthol grinding will dissolve, and add and beta carotene and vitamin E and atoleine stirring is 2. made
Mix, be made（A）Agent；Respectively will more than 3. 4. 5. 6. 7. obtained titrol in method, perilla herb oil, cade oil, deep
Careless oil and lemon oil are mixed to prepare（B）Agent；The deionized water measured and denatured alcohol are pumped into reactor, thrown while stirring
Enter Tween-80, after stirring, sequentially add（A）With（B）Component, continuing stirring certain time can be canned.
The excellent effect of the present invention is as follows：
Because this research project is using natural plant extraction volatile oil as raw material, it is aided with vitamin E, beta carotene, denaturation wine
Essence, deionized water and Tween-80, it ensure that natural volatile oil component efficient, safety can act on affected part, played clear
Thermal detoxification, eliminating stasis to subdue swelling, anti-inflammation, analgesia, wind-dispelling, dehumidifying, the drug effect such as stimulate circulation, for treat athletic injury,
Surprisingly pull wait accidental injury and muscle arthrosis pain, it can also be used to sports health, joint nurse；Under its active ingredient is located at
Layer, be avoided that in storage process because the active ingredients such as volatile oil volatilization scatter and disappear caused by drug effect reduce, and shake up breast
Liquid, enhance Transdermal absorption.
Titrol in formula, is the pure plant volatile oil extracted from Cajeputtree Leaf, and wide spectrum resists micro- life
Thing, strong disinfecting health care, anti-inflammatory, and pollution-free, non-corrosiveness, permeability are strong.
Perilla herb oil in formula, it is a kind of natural oil for the high degree of unsaturation extracted from perilla seed, disappears containing antibacterial
Scorching, antiviral isoreactivity, there is very strong inoxidizability to suppress allergic reaction, swelling and pain, treatment of arthritis can be mitigated.
Cade oil in formula, it is the pure plant volatile oil extracted from needle juniper cone, wind-dispelling, invigorating blood circulation analgesia, removes
It is wet to treat chornic arthritis, gout and rheumatoid disease.
In formula lopseed oil, dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, promoting blood circulation and stopping pain, stimulate the menstrual flow it is deep, external application have anti-inflammatory, sterilization,
Restrain surface of a wound effect.
Levorotatory menthol in formula, extracted from natural peppermint, adjust vascular function, local topical anti-inflammatory, analgesic.
Beta carotene in formula, is extracted from the fruit of Chinese wolfberry, can strengthen the metabolism of skin, promotes blood circulation.
Vitamin E in formula, local blood supply can be improved, promote wound healing, can be acted synergistically with perilla herb oil,
Be advantageous to its absorption.
Denatured alcohol in formula, the molecule of denatured alcohol have very big penetrating power, and it can pass through bacterium surface
Film, the inside of bacterium is squeezed into, make the protein coagulating of composition bacterium Life Base, bacterium is killed.Alcohol can row medicine gesture make
The effect of promoting circulation of blood medicine is preferably played, and can releive pain of joint muscle.
Tween-80 in formula, drug particle dispersiveness and the wetability of surface of drug particles, enhancing can be promoted
Transdermal absorption, base on our country, be easy to get.
Lemon oil in formula, is extracted from lemon, has good convergence and antibacterial action.
This anti-inflammatory, which unstings, is layered that oily production technology is relatively simple, and the key of technical process is carrying for plant volatile oil with compound
Take the proportioning with preferred Tween-80 and alcohol.Technical process is as follows：
Technical process：
（1）By peppermint by supercritical carbon dioxide fluid extraction extraction levorotatory menthol crystal；
（2）By the fruit of Chinese wolfberry by microblogging auxiliary extraction method extraction beta carotene；
（3）Melting levorotatory menthol, beta carotene, vitamin E and purification paraffin are stirred and evenly mixed；
（4）By narrow leaved tea tree by solvent way of distillation extraction titrol；
（1）By perilla seed by supercritical fluid method extraction perilla herb oil；
（2）Cade oil and lopseed oil are extracted by needle juniper, through grass by supercritical carbon dioxide fluid extraction respectively；
（3）By lemon by cool-milling extraction method extraction lemon oil；
（4）Titrol, perilla herb oil, cade oil, lopseed oil and lemon oil are mixed；
（5）The deionized water measured and alcohol are added in the homogenizer with stirring, put into Tween-80 while stirring,
After stirring, sequentially add（A）With（B）Component, stirring homogenizing time 40 minutes is to well mixed.
（6）By above-mentioned layering oil by filtering, stirring bottling, vanning storage.
Brief description of the drawings
Accompanying drawing 1 is the structural representation of the present invention；
Accompanying drawing 2 is structural representation of the invention；
Accompanying drawing 3 is structural representation of the invention.
Embodiment
The present invention is described in detail below with reference to Figure of description.
Embodiment 1：
The anti-inflammatory unstings is layered oil with compound, is to be prepared from the following raw materials in parts by weight：Levorotatory menthol, β-carrot
Element, 30 parts of vitamin E and atoleine mixed solution；Narrow leaved tea tree, purple perilla, lopseed, needle juniper and 6 kinds of mixing of lemon
50 parts of oil；Edible alcohol, deionized water and Tween-80 amount to 20 parts.
Preparation method is as follows：
1. extracting menthol from natural peppermint using supercritical carbon dioxide, levorotatory menthol is separated to obtain through distilling crystallisation；
2. beta carotene is extracted from the fruit of Chinese wolfberry using microwave-assisted；3. using the solvent way of distillation from it is fresh or dry it is mutual
Titrol is extracted in leaf cajeputtree branches and leaves；4. it will be extracted after perilla seed drying, crushing using supercritical fluid extraction
Perilla herb oil；5. cade oil is extracted from needle juniper cone using ultrasound-enhanced supercritical CO2 extractions；6. super faced using ultrasound-enhanced
Boundary's CO2 extractions extract lopseed oil from lopseed；7. lemon oil is extracted from lemon using cool-milling extraction method.
1. the grinding of obtained levorotatory menthol will dissolve, add 2. be made beta carotene and, vitamin and atoleine stirring
Mix, be made（A）Agent；Respectively will more than 3. 4. 5. 6. 7. obtained titrol in method, perilla herb oil, cade oil, deep
Careless oil and lemon oil are mixed to prepare（B）Agent；The deionized water measured and alcohol are pumped into reactor, input is poly- while stirring
Sorb ester -80, after stirring, sequentially add（A）With（B）Component, continuing stirring certain time can be canned.
Embodiment 2：
The anti-inflammatory unstings is layered oil with compound, is to be prepared from the following raw materials in parts by weight：Levorotatory menthol, beta carotene,
25 parts of vitamin E and atoleine mixed solution；Narrow leaved tea tree, purple perilla, lopseed, needle juniper and 6 kinds of miscellas 40 of lemon
Part；Edible alcohol, deionized water and Tween-80 amount to 35 parts.
Preparation method is same as Example 1.
Embodiment 3：
The anti-inflammatory unstings is layered oil with compound, is to be prepared from the following raw materials in parts by weight：Levorotatory menthol, beta carotene,
28 parts of vitamin E and atoleine mixed solution；Narrow leaved tea tree, purple perilla, lopseed, needle juniper and 6 kinds of miscellas 45 of lemon
Part；Edible alcohol, deionized water and Tween-80 amount to 27 parts.
Preparation method is same as Example 1.
Embodiment 4：
The anti-inflammatory unstings is layered oil with compound, is to be prepared from the following raw materials in parts by weight：Levorotatory menthol, beta carotene,
32 parts of vitamin E and atoleine mixed solution；Narrow leaved tea tree, purple perilla, lopseed, needle juniper and 6 kinds of miscellas 50 of lemon
Part；Edible alcohol, deionized water and Tween-80 amount to 18 parts.
Preparation method is same as Example 1.
Embodiment 5：
The anti-inflammatory unstings is layered oil with compound, is to be prepared from the following raw materials in parts by weight：Levorotatory menthol, beta carotene,
30 parts of vitamin E and atoleine mixed solution；Narrow leaved tea tree, purple perilla, lopseed, needle juniper and 6 kinds of miscellas 55 of lemon
Part；Edible alcohol, deionized water and Tween-80 amount to 15 parts.
Preparation method is same as Example 1.
The production that anti-inflammatory unstings with compound layering oil, crucial technique are the extraction of plant volatile oil and preferred poly- sorb
The proportioning of ester -80 and alcohol.
The extraction of this plant volatile oil has selected supercritical carbon dioxide, microwave auxiliary extraction, solvent distillation etc. advanced
Extracting method.Using denatured alcohol, using recrystallization, cloud point, extraction combination method and three phase separation method jointly to Tween-80
Refined, by repetition test, determine the optimum proportioning of alcohol, deionized water and Tween-80.
Application method：External application：Shaken up before use emulsion, painting put on the skin in affected part, before and after motion.It can play and control
Treat caused strain, scratch in motion, the effect of pain of joint muscle.
Volatile oil is extracted as functional raw material using pure plant, is aided with vitamin E, beta carotene, alcohol, deionization
Water and Tween-80 make base-material, due to being related to plant volatile oil and its matrix formulations, belong to current unexpected winner investigative technique neck
Domain, the invention success that the anti-inflammatory unstings with compound layering oil, by for the research of natural volatile oil and application opened up one it is new
New contribution is made in the accidental injuries such as field is athletic injury, is surprisingly pulled and the treatment of pain of joint muscle.Like for motion
Person, the elderly's working bow race etc. while bring glad tidings, and the characteristic for also having played Chinese medicine in national athletic rehabilitation etc. is made
With sport and body-building will be turned into, the essential product of joint nursing.
It is the known technology of those skilled in the art in addition to the technical characteristic described in specification.
Claims (5)
1. claims
A kind of anti-inflammatory unstings is layered oil formula with compound, it is characterised in that is to be prepared from the following raw materials in parts by weight：
（A）Agent：Levorotatory menthol, beta carotene, vitamin E and atoleine mixed solution 25-35 parts；
（B）Agent：Narrow leaved tea tree, purple perilla, lopseed, needle juniper and 6 kinds of miscella 40-55 parts of lemon；
（C）Agent：Denatured alcohol, deionized water and Tween-80 15-25 parts；
Preparation method：
1. extracting menthol from natural peppermint using supercritical carbon dioxide, levorotatory menthol is separated to obtain through distilling crystallisation；
2. beta carotene is extracted from the fruit of Chinese wolfberry using microwave-assisted；3. using the solvent way of distillation from it is fresh or dry it is mutual
Titrol is extracted in leaf cajeputtree branches and leaves；4. it will be extracted after perilla seed drying, crushing using supercritical fluid extraction
Perilla herb oil；5. cade oil is extracted from needle juniper cone using ultrasound-enhanced supercritical CO2 extractions；6. super faced using ultrasound-enhanced
Boundary's CO2 extractions extract lopseed oil from lopseed；7. lemon oil is extracted from lemon using cold grinding filtration method；
1. it the grinding of obtained levomenthol will dissolve, and add and bata-carotene, vitamin E and atoleine is 2. made stirs and evenly mixs,
It is made（A）Agent；Respectively will more than 3. 4. 5. 6. 7. obtained titrol in method, perilla herb oil, cade oil, lopseed oil and
Lemon oil is mixed to prepare（B）Agent；The deionized water measured and denatured alcohol are pumped into reactor, put into poly- mountain while stirring
Pear ester -80, after stirring, sequentially add（A）With（B）Component, continuing stirring certain time can be canned.
2. a kind of anti-inflammatory according to claim 1 unstings is layered oil formula with compound, it is characterised in that is by following weight
Proportioning is preferably：
（A）Agent：30 parts of levorotatory menthol, beta carotene, vitamin E and atoleine mixed solution；
（B）Agent：Narrow leaved tea tree, purple perilla, lopseed, needle juniper and 50 parts of 6 kinds of miscellas of lemon；
（C）Agent：20 parts of denatured alcohol, deionized water and Tween-80.
3. according to the method for claim 1, it is characterised in that plant volatile oil in formula, be derived from pure natural, preparation extraction
Technique is advanced, and the cost of raw material is low, utilization rate is high；It contains anti-inflammation, antiviral, promoting blood circulation and stopping pain isoreactivity composition, external application
It is applied to the wind-dispelling of affected part energy effective antiinflammatory, promoting blood circulation is unsting, the accidental injuries such as treatment athletic injury, accident are pulled and articular muscle pain
Bitterly, it can also be used to sports health, joint nursing.
4. according to the method described in claim 1,3, it is characterised in that make use of multiple hydroxyls of Tween-80（—OH）
With ether chain（-O-）The proportioning of effect in group water-oil system, preferably ethanol and Tween-80, obtained transparent layering
Oil, volatile oil so can effectively avoid the drug effect caused by volatile oil scatters and disappears from reducing in lower floor, and shake up emulsion.
5. according to the method described in claim 1,3, it is characterised in that anti-inflammatory unstings is layered oil with compound, wherein containing dimension life
Plain E, Tween-80, bata-carotene and alcohol water blend, drug particle dispersiveness and wettability of the surface can be promoted, increased
Strong Transdermal absorption.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710718641.4A CN107375486A (en) | 2017-08-21 | 2017-08-21 | Anti-inflammatory unstings is layered oil formula with compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710718641.4A CN107375486A (en) | 2017-08-21 | 2017-08-21 | Anti-inflammatory unstings is layered oil formula with compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375486A true CN107375486A (en) | 2017-11-24 |
Family
ID=60352853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710718641.4A Pending CN107375486A (en) | 2017-08-21 | 2017-08-21 | Anti-inflammatory unstings is layered oil formula with compound |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107375486A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475790A (en) * | 2010-11-29 | 2012-05-30 | 吴克 | Liquid preparation for relieving stuffy noses, soothing nerves and reducing symptoms of carsickness, snore and like |
| CN104274634A (en) * | 2014-08-14 | 2015-01-14 | 杭州方回春堂国药馆有限公司 | Compound plant essential oil for refreshing, restoring consciousness, diminishing swelling and relieving itching and preparation method of compound plant essential oil |
| CN106729070A (en) * | 2016-12-23 | 2017-05-31 | 曾惠民 | A kind of external application energy gauging for mitigating arthralgia and preparation method thereof |
-
2017
- 2017-08-21 CN CN201710718641.4A patent/CN107375486A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475790A (en) * | 2010-11-29 | 2012-05-30 | 吴克 | Liquid preparation for relieving stuffy noses, soothing nerves and reducing symptoms of carsickness, snore and like |
| CN104274634A (en) * | 2014-08-14 | 2015-01-14 | 杭州方回春堂国药馆有限公司 | Compound plant essential oil for refreshing, restoring consciousness, diminishing swelling and relieving itching and preparation method of compound plant essential oil |
| CN106729070A (en) * | 2016-12-23 | 2017-05-31 | 曾惠民 | A kind of external application energy gauging for mitigating arthralgia and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 国家中医药管理局专业技术资格考试专家委员会: "《全国中医药专业技术资格考试大纲与细则.中药专业：中级》", 30 November 2016, 中国中医药出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103830440B (en) | Essential oil with sedative effect | |
| CN107233412A (en) | It is a kind of to promote compound essential oil composition of sleep and its production and use | |
| CN103479775B (en) | Scraping liniment and preparation method thereof | |
| CN104027399A (en) | Essential oil composition and preparation method thereof | |
| CN105727236A (en) | Powder for treating red skin disease of osphronemus goramy and preparation method thereof | |
| CN101972376A (en) | Chinese medicinal ointment for treating intervertebral disc hyperosteogeny and preparation method thereof | |
| CN106975063A (en) | A kind of new bone setting plaster and preparation method thereof | |
| CN104027439B (en) | Compositions and preparation method thereof | |
| CN101190277B (en) | Method for preparing stemmacantha uniflora blood circulation-activating, stasis-removing and wind-damp-expelling wine | |
| CN109432380A (en) | A kind of warming and activating meridian, liquid moxa-moxibustion pharmaceutical preparation of yang-tonifying promoting blood circulation and preparation method thereof | |
| CN110882299A (en) | Soothing massage essential oil and preparation method thereof | |
| CN107375486A (en) | Anti-inflammatory unstings is layered oil formula with compound | |
| CN104083311A (en) | Natural plant-derived functional massage lotion | |
| CN108379529A (en) | A kind of waist kidney essential oil for maintaining and preparation method thereof | |
| CN103055062A (en) | Granule infusion for heat clearing and dampness dispelling, and its preparation method | |
| CN106214908A (en) | A kind of obesity Chinese medicine external for the treatment of smears the preparation method of unguentum | |
| CN105920130A (en) | Preparation method and externally used ointment of traditional Chinese medicine for treating talalgia | |
| CN107582495A (en) | The both effectiveness nanometer massage lotion of natural plants | |
| CN105902965A (en) | Blood circulation activating ointment for treating bone diseases and preparation method thereof | |
| CN105617330A (en) | External essential oil for quickly eliminating skin inflammation | |
| CN100377703C (en) | Method for making embossed-rod Chinese herbal medicine composition | |
| CN104922449A (en) | Traditional Chinese medicine disinfection solution and preparation method thereof | |
| CN108420969A (en) | Four seasons anti-acne honey prolongs slurry and its preparation process | |
| CN103232931A (en) | Vitamin, microelement and pine pee series health-care snake medicinal liquor for prolonging life | |
| CN108295215A (en) | A kind of Chinese medicine preparation and preparation method for treating the left paralysis and right paralysis of body after apoplexy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171124 |