CN107375428A - A kind of ointment of Prozac combination traditional Chinese medicine ingredients treatment leucoderma and preparation method thereof - Google Patents
A kind of ointment of Prozac combination traditional Chinese medicine ingredients treatment leucoderma and preparation method thereof Download PDFInfo
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- CN107375428A CN107375428A CN201710596599.3A CN201710596599A CN107375428A CN 107375428 A CN107375428 A CN 107375428A CN 201710596599 A CN201710596599 A CN 201710596599A CN 107375428 A CN107375428 A CN 107375428A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The invention belongs to technical field of medicine.It is related to a kind of Prozac ointment for treating leucoderma.The ointment is prepared by Integrated TCM.It is standby with the method extraction active ingredients from traditional Chinese medicinal of ultrasound first, Prozac is dissolved in standby in propane diols；Secondly a certain amount of water-phase component and emulsifying agent are added to stirring in a certain amount of oil-phase component and emulsifiable paste matrix is made；Finally medicine and preservative are added in matrix and obtain finished product.The present invention is prepared simply, and therapeutic effect is notable.
Description
Technical field
The invention belongs to technical field of medicine.More particularly to a kind of ointment for treating leucoderma.
Background technology
Leucoderma is a kind of more typical posteriority depigmentation disease, is characterized in epidermis, mucous membrane and its hetero-organization
Melanocyte lacks, and the incidence of disease is 0.5%~2%, without obvious race and gender differences.Its pathogenesis may be with heredity, god
It is relevant through many factors such as endocrine, autoimmunities.The pathogenic factor of leucoderma be it is not immediately clear, therefore it is treated also more
It is difficult.
Prozac, Chinese nickname are fluothane aniline propyl ether；Entitled N- methyl -3- (p- the 4-trifluoromethylphenopendant) -3- of chemistry
Phenylpropylamine, it is used as antidepressants with the drug form of hydrochloride more.As antidepressants.There is research to show that Prozac can be with
Increase cell tyrosinase（Tyrosine）Activity, MITF is improved, the level of TYR and TRP-1 protein, finally makes mouse B16F10
Melanoma cells and normal human melanoma's cell（NHMCs）Synthesis of melanin dramatically increases.
The traditional Chinese medical science is basic using promoting blood circulation and removing blood stasis, dispelling wind and removing obstruction in the meridians to this sick treatment at present.The most flavour of a drug of applying frequency have：Female
Loyal son, sweat lotus grass, semen astragali complanati, tribulus terrestris, the root of Dahurain angelica, psoralea corylifolia, Ligusticum wallichii, safflower, the Radix Astragali etc..External application Chinese medicine is more from fragrant containing furans
Tincture is made in the medicine of legumin class material, to increase its permeability.Prozac is combined for treating leucoderma with traditional Chinese medicine ingredients,
The combination of Chinese tradiational and Western medicine, the two complementary length, curative effect is improved, be to treat one of trend of leucoderma from now on.
The content of the invention
The present invention is in order to make up the technological gap of existing Prozac external used medicine, and also to solve, therapy of vitiligo is difficult to be showed
Shape.Provide a kind of ointment formulation for being used to treat pigment decolouring disease.The pigment decolouring disease especially skin disease leucoderma
Wind.The ointment is as made by Integrated TCM.
The present invention is achieved through the following technical solutions：
（1）The extraction of traditional Chinese medicine ingredients
Weigh 10 ~ 15g of psoralea corylifolia, 10 ~ 15g of the root of Dahurain angelica, 2 ~ 6g of the Radix Astragali, 15 ~ 20g of tribulus terrestris, 8 ~ 12g of safflower, Ligusticum wallichii 8 ~
12g, 3 ~ 8g of fig plus 40 times of water ultrasonic wave extraction 30min, then decocting and concentrating is standby.
（2）The preparation of Prozac medicine
The mg of Prozac 10 is dissolved in standby in 7.5 mL propane diols.
（3）The preparation of matrix
Take lauryl sodium sulfate 1.0g, 0.1 ~ 1.0mL of triethanolamine, 2.0 ~ 3.0mL of glycerine, purified water 50mL, heating water bath
To 80 DEG C（Aqueous phase）；Separately take 3 ~ 5g of stearic acid, 3 ~ 5mL of paraffin hydrocarbons, 1 ~ 2g of albolene, 3 ~ 5g of octadecyl alcolol, monostearate sweet
1 ~ 2g of grease heating water baths are to 80 DEG C（Oil phase）；Aqueous phase is added into oil phase and forms emulsifiable paste, and is stirred continuously.
（4）The preparation of Prozac ointment
Finally the ethyl hydroxy benzoate of Chinese medicine extract, Prozac medicine and 50 μ L is added in emulsifiable paste and continues to stir, is slowly cooled to
Room temperature.
Preferably, the extraction of the traditional Chinese medicine ingredients, weighed by following weight：Psoralea corylifolia 15g, root of Dahurain angelica 12g, Radix Astragali 5g, thorn
Puncture vine 20g, safflower 8g, Ligusticum wallichii 10g, fig 5g.
Preferably, the preparation of the matrix, lauryl sodium sulfate 1.0g, triethanolamine 1.0mL, glycerine 2.5mL, pure is taken
Change water 50mL, heating water bath is to 80 DEG C（Aqueous phase）；Separately take stearic acid 3g, paraffin hydrocarbons 3.5g, albolene 1.5g, octadecyl alcolol
3.5g, glycerin monostearate 2g heating water baths are to 80 DEG C（Oil phase）；Aqueous phase is added into oil phase and forms emulsifiable paste, and is stirred continuously.
The beneficial effects of the invention are as follows：By the combination of Chinese tradiational and Western medicine, by promoting blood circulation and removing blood stasis, dispelling wind and removing obstruction in the meridians means with stimulating junket ammonia
Phytase activity, promote biochemical apparatus caused by melanin to be merged, in combination with appropriate sunbath, make the healing of leucoderma
Rate greatly improves.The therapeutic modality of external-applied ointment is simply easy to be accepted by patients, and Small side effects.
Embodiment
With reference to specific embodiment, the present invention will be further described, it will be appreciated that embodiment described herein is only used for
The description and interpretation present invention, is not intended to limit the present invention.
Embodiment 1
Weigh psoralea corylifolia 10g, root of Dahurain angelica 10g, Radix Astragali 2.0g, tribulus terrestris 15g, safflower 8.0g, Ligusticum wallichii 8.0g, fig 3.0g, plus
40 times of water ultrasonic wave extraction 30min, then decocting and concentrating is standby to 100g；Prozac 20mg is dissolved in standby in 15mL propane diols；
Triethanolamine 0.1mL, lauryl sodium sulfate 1.0g, glycerine 2.0mL, purified water 50mL are taken, heating water bath is to 80 DEG C（Aqueous phase）；
Separately take octadecyl alcolol 3.0g, glycerin monostearate 1.0g, stearic acid 3.0g, paraffin hydrocarbons 3.0mL, albolene 1.0g, water-bath
It is heated to 80 DEG C（Oil phase）；Aqueous phase is added into oil phase and forms emulsifiable paste, and is stirred continuously, medicine is added and the μ L of ethyl hydroxy benzoate 50 continues
Stirring, is slowly cooled to room temperature, obtains Prozac ointment.
Embodiment 2
Weigh psoralea corylifolia 15g, root of Dahurain angelica 15g, Radix Astragali 6.0g, tribulus terrestris 20g, safflower 12g, Ligusticum wallichii 12g, fig 8.0g plus 40
Times water ultrasonic wave extraction 30min, then decocting and concentrating is standby to 100g；Prozac 20mg is dissolved in standby in 15mL propane diols；Take
Triethanolamine 1.0mL, lauryl sodium sulfate 1.0g, glycerine 3mL, purified water 50mL, heating water bath is to 80 DEG C（Aqueous phase）；Separately take
Octadecyl alcolol 5.0g, glycerin monostearate 2.0g, stearic acid 5.0g, paraffin hydrocarbons 5.0mL, albolene 2.0g, heating water bath
To 80 DEG C（Oil phase）；Aqueous phase is added into oil phase and forms emulsifiable paste, and is stirred continuously, medicine is added and the μ L of ethyl hydroxy benzoate 50 continues to stir
Mix, be slowly cooled to room temperature, obtain Prozac ointment.
Embodiment 3
Weigh psoralea corylifolia 15g, root of Dahurain angelica 12g, Radix Astragali 5.0g, tribulus terrestris 20g, safflower 8.0g, Ligusticum wallichii 10g, fig 5.0g plus 40
Times water ultrasonic wave extraction 30min, then decocting and concentrating is standby to 100g；Prozac 20mg is dissolved in standby in 15mL propane diols；Take
Triethanolamine 1.0mL, lauryl sodium sulfate 1.0g, glycerine 2.5mL, purified water 50mL, heating water bath is to 80 DEG C（Aqueous phase）；Separately
Octadecyl alcolol 3.0g, glycerin monostearate 3.5g, stearic acid 1.5g, paraffin hydrocarbons 3.5mL, albolene 2.0g are taken, water-bath adds
Heat is to 80 DEG C（Oil phase）；Aqueous phase is added into oil phase and forms emulsifiable paste, and is stirred continuously, medicine is added and the μ L of ethyl hydroxy benzoate 50 continues to stir
Mix, be slowly cooled to room temperature, obtain Prozac ointment.
Preliminary experiment in the animal body of the Prozac ointment of embodiment 4
Choose C57BL/6 mouse, there is provided sterilizing feed and drinking-water.Control environment temperature（22±1）DEG C, the 12h light/dark cycles（7:
00/19:00）.The d of mouse pre-adaptation environment 5 before being tested.And test (open-field test) with spacious field and carry out behavior
Learn scoring.Housing choice behavior learns point a similar mouse 40, is randomly divided into 4 groups using the softwares of PEMS 3.0, every group 10, i.e. sky
White control group（Ctrl groups）, chronic unpredictable Stress model group（CUMS groups）, Prozac ointment group（20mg/kg, 2 times/
My god）, butin ointment group（4mg/kg, 2 times/day）.Back part of animal hair is sloughed with rosin/mineral wax mixture within 1 day before experiment
With the synchronous hair follicles cycle of induction.Successive administration 12 days.Mouse back skin face is photographed to record in administration within the 1st, 8,12 day
Pornographic condition observation Prozac ointment synchronizes the influence of C57BL/6 mouse hair follicles melanocyte and melanin genesis protein expression to depilation.
Chronic unpredictable stress stimulation：With once a day frequency alternately stress mouse 21d, stress include：4 DEG C of frozen water
Swimming（5min）, 45 DEG C of thermostimulations（5min）, press from both sides tail（2min）, Restraint Stress（4h）, vola of shocking by electricity（Electric current 0.6mA, one minute
Twice, common 1h）, suspention（5min）, prohibit water（24h）Deng.It is every kind of to stimulate the hair for adding up using 3 times, to prevent mouse from expecting stimulation
It is raw.It stress handle in the daily morning（9：00-12：00）Carry out.
Depilation synchronizes：The 8th day after stress stimulation starts（I.e. the 12nd day before animal tissue's sampling）, by rosin and paraffin
By 1:The heating of 1 ratio is dissolved, and mouse back is applied to when temperature is adapted to, it is to be solidified be hardened after tear rapidly, slough its back
Hair, area are 2 × 2cm2, and induction hair follicle synchronizes and enters growth period.
Experimental result（See Fig. 1）Display Prozac administration group mouse hair removal section skin color is significantly deepened.Prove this fluorine west
Spit of fland ointment can remarkably promote the melanin genesis that depilation synchronizes C57BL/6 mouse skins.Fig. 1 be Prozac ointment to it is chronic can not
Foresight stress the growth of mouse hair removal section skin and hair and the influence of hair color.
Ointment quality evaluation is tested：
1st, ointment character observation
Prepare after ointment room temperature places 24h and take pictures by each prescription；
As seen from Figure 2 the products obtained therefrom uniform color of embodiment 1,2,3, denseness is suitable, quality is fine and smooth, is easy to coating level and whether there is
Granular sensation.Fig. 2 is ointment appearance character.
2nd, dewatering ability
Prepared by prescription and centrifuge 30 in 2500 g/min when ointment respectively takes 1 mL to be cooled to room temperature in 1.5 mL EP pipes
Min, observation whether there is lamination, as a result see Fig. 3.Fig. 3 is the outside drawing after the centrifugation of each prescription.
Take respectively centrifugation before, centrifugation after the g of bottom of the tube ointment 0.05, with ultra-pure water dilute 250 times, take 200 μ L in 300
At nm wavelength measure centrifugation before absorbance (A0) and centrifuge after absorbance (AA), using formula Ke=（| A0-AA |/AA）*100%
Aspire for stability constant, stability constant is more big more unstable.It the results are shown in Table 1.Table 1 is dewatering ability table.
3rd, resist cold stability
Ointment is prepared by each prescription, takes 1 mL ointment in 1.5 mL EP pipes after room temperature places 24 h, respectively at 4 DEG C, -25
DEG C, -70 DEG C of refrigerators take out after placing 24 h, place to room temperature and centrifuge 10 min observations whether there is layering after 2500 g/min, tie
Block, phenomena such as lotion is thicker.It the results are shown in Table 2.Table 2 is cold-resistant stability table.
4th, heat-resistant stability
Ointment is prepared by each prescription, takes 1 mL ointment in 1.5 mL EP pipes after room temperature places 24 h, respectively at normal temperature, 37
DEG C, 60 DEG C, 80 DEG C of refrigerators take out after placing 24 h, place and centrifuge 10 min observations after 2500 g/min to room temperature and whether there is point
Layer, caking, phenomena such as lotion is thicker.It the results are shown in Table 3.Table 3 is each prescription heat-resistant stability and grade form.
5th, ductility
24 h are placed after preparing ointment formulation by each prescription, each g of prescription ointment 1 is weighed and is placed in the cm sizes of two piece of 10 cm × 10
Clean glass plate between, one piece of g of weight 125 is placed above（Deficiency plus counterweight supply quality）, surveyed with precision straight edge after 1 min
Ointment diameter after fixed extension, the average value of maximum gauge and minimum diameter is taken, value is bigger, and ductility is better.It the results are shown in Table 4.
Table 4 is each prescription ductility and scoring.
6th, pH value
Ointment is prepared by each prescription, the g of each group ointment 1 is taken after the h of room temperature 24, adds the mL of purified water 5, stirs, is surveyed with PH test paper
Determine each group PH.It the results are shown in Table 5.Table 5 is each prescription pH value and grade form.
7th, the fine and smooth uniformity
Ointment is prepared by each prescription, takes appropriate ointment to be placed on slide after the h of room temperature 24, applies straticulation, plus cover glass, 200
Microscopy is observed under power microscope.As a result Fig. 4 is seen.Fig. 4 is each prescription exquisiteness uniformity.
Summarize：Above example can obtain the preferable Prozac ointment of quality, wherein, the acquired results of embodiment 3 are
Optimal.
Claims (4)
- A kind of 1. ointment of Prozac combination traditional Chinese medicine ingredients treatment leucoderma, it is characterised in that the Chinese medicine including following quality into Point：10 ~ 15g of psoralea corylifolia, 10 ~ 15g of the root of Dahurain angelica, 2 ~ 6g of the Radix Astragali, 15 ~ 20g of tribulus terrestris, 8 ~ 12g of safflower, 8 ~ 12g of Ligusticum wallichii, fig 3 ~ 8g and Prozac and ointment bases that mass ratio is 0.01% ~ 0.015%.
- 2. the ointment of a kind of Prozac combination traditional Chinese medicine ingredients treatment leucoderma according to claim 1, it is characterised in that logical Following steps are crossed to be prepared：（1）Ultrasonic method extracts effective component of chinese medicine；（2）Prozac is dissolved in standby in propane diols；（3） Prepare ointment bases；（4）Obtained stirring is continued in Chinese medicine extract, Prozac medicine, ethyl hydroxy benzoate addition ointment bases most Finished product.
- A kind of 3. ointment of Prozac combination traditional Chinese medicine ingredients treatment leucoderma according to claim 1, it is characterised in that its Ointment bases is prepared by following methods：Take lauryl sodium sulfate 1.0g, 0.1 ~ 1.0mL of triethanolamine, glycerine 2.0 ~ 3.0mL, purified water 50mL, heating water bath is to 80 DEG C（Aqueous phase）；It is another take 3 ~ 5g of stearic acid, 3 ~ 5mL of paraffin hydrocarbons, albolene 1 ~ 2g, 3 ~ 5g of octadecyl alcolol, 1 ~ 2g of glycerin monostearate heating water baths are to 80 DEG C（Oil phase）；Aqueous phase is added into oil phase and forms emulsifiable paste, And it is stirred continuously.
- 4. a kind for the treatment of leucoderma of the ointment of Prozac combination traditional Chinese medicine ingredients treatment leucoderma according to claim 1 Purposes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020238570A1 (en) | 2019-05-28 | 2020-12-03 | 南京睿鹰润泽生物医药科技有限公司 | Composition containing fluoxetine and vitamin d 3 or its derivatives, and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102429894A (en) * | 2011-12-07 | 2012-05-02 | 中国药科大学 | Application of fluoxetine to treatment of depigmentation disease |
| CN106667903A (en) * | 2017-01-05 | 2017-05-17 | 山东润泽制药有限公司 | Fluoxetine tincture for treating leucoderma |
-
2017
- 2017-07-20 CN CN201710596599.3A patent/CN107375428A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102429894A (en) * | 2011-12-07 | 2012-05-02 | 中国药科大学 | Application of fluoxetine to treatment of depigmentation disease |
| CN106667903A (en) * | 2017-01-05 | 2017-05-17 | 山东润泽制药有限公司 | Fluoxetine tincture for treating leucoderma |
Non-Patent Citations (2)
| Title |
|---|
| 旷惠桃: "《名医推荐家庭必备药膳 珍藏本》", 30 September 2015, 湖南科学技术出版社 * |
| 杨华等: "白癜风中医外治研究概述", 《中国中西医结合皮肤性病学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020238570A1 (en) | 2019-05-28 | 2020-12-03 | 南京睿鹰润泽生物医药科技有限公司 | Composition containing fluoxetine and vitamin d 3 or its derivatives, and application thereof |
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Application publication date: 20171124 |